JOURNAL TRANSCRIPT

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2820

MIURA K et al.

ORIGINAL ARTICLE

Circ J 2018; 82: 2820 – 2828 doi: 10.1253/circj.CJ-18-0464

Imaging

Optical Coherence Tomography Predictors for Recurrent Restenosis After Paclitaxel-Coated Balloon Angioplasty for Drug-Eluting Stent Restenosis Katsuya Miura, MD; Takeshi Tada, MD, PhD; Seiji Habara, MD; Akimune Kuwayama, MD; Takenobu Shimada, MD; Masanobu Ohya, MD; Ryosuke Murai, MD; Hidewo Amano, MD; Shunsuke Kubo, MD; Suguru Otsuru, MD; Hiroyuki Tanaka, MD; Yasushi Fuku, MD; Tsuyoshi Goto, MD; Kazushige Kadota, MD, PhD Background:  Little is known of the relationship between optical coherence tomography (OCT) findings and recurrent restenosis after paclitaxel-coated balloon (PCB) angioplasty for drug-eluting stent in-stent restenosis (DES-ISR). To identify the predictors of recurrent restenosis after PCB angioplasty, we investigated quantitative and qualitative OCT findings during PCB angioplasty for DES-ISR. Methods and Results:  In all, 222 DES-ISR lesions treated by PCB angioplasty with OCT assessment and followed-up angiographically at 6 months were divided into restenotic and non-restenotic lesions on the basis of the presence or absence of restenosis at follow-up. There was a significantly higher proportion of the heterogeneous tissue pattern in restenotic than non-restenotic lesions (26.5% vs. 11.0%, respectively; P=0.02). The OCT-derived post-procedural minimal lumen and stent areas were significantly smaller in restenotic lesions, but the intima area was similar in both groups. Post-procedural stent underexpansion, defined as a stent diameter : size of the previous stent ratio