JOURNAL TRANSCRIPT

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CURRICULUM VITAE NAME:

JOHN BRADLEY HOLCOMB, M.D., F.A.C.S.

PRESENT TITLE:

Director, Center for Translational Injury Research Chief, Division of Acute Care Surgery Professor of Surgery Vice Chair, Department of Surgery Jack H. Mayfield, M.D. Chair in Surgery

ADDRESS:

The University of Texas Medical School at Houston Department of Surgery 6431 Fannin, Room 4.170 Houston TX, 77030 Telephone: 713.500.7218 Fax: 713.500.7213 Email: [email protected]

BIRTHDATE:

17 June 1959

CITIZENSHIP:

U.S.A.

March 2013

SECURITY CLEARANCE: Top Secret UNDERGRADUATE EDUCATION: 1977-1981

B.S., Biology with Honors, Cum Laude, Centenary College, Shreveport, LA

GRADUATE EDUCATION: 1981-1985

M.D., University of Arkansas Medical School, Little Rock, AR

POST-GRADUATE TRAINING: 1985-1986

General Surgery Intern, William Beaumont Army Medical Center, El Paso, TX

1987-1991

General Surgery Resident, William Beaumont Army Medical Center, El Paso, TX

2001-2002

Surgical Critical Care Fellow, The University of Texas Medical School at Houston, Houston, TX

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Holcomb, J.B. CV March 2013

HOSPITAL APPOINTMENTS: 1991-1994

Staff General Surgeon, Womack Army Medical Center, Ft. Bragg, NC

1994-1997

Surgery Attending, General Surgery Service, William Beaumont Army Medical Center, El Paso, TX

1997-1999

Surgical Attending, Brooke Army Medical Center, Ft. Sam Houston, TX

1999-2001

Surgery Faculty, Ben Taub General Hospital, Houston, TX

1999-2001

Director, Joint Trauma Training Center, Houston, TX

2012-present

Director, Texas Trauma Institute, Memorial Hermann Hospital, Houston, TX

2012-present

Trauma Medical Director, Memorial Hermann Hospital, Houston, TX

ACADEMIC APPOINTMENTS: 1991-1994

Assistant Consulting Professor of Surgery, Duke University Medical Center, Durham, NC

1991 – 2001

Assistant Professor of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD

1999-2001

Assistant Professor of Surgery, Baylor College of Medicine, Houston, TX

2001-2008

Clinical Assistant Professor of Surgery, The University of Texas Medical School at Houston, Houston, TX

2001-present

Associate Professor of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD

2006-2008

Clinical Professor of Surgery, The University of Texas Health Sciences Center, San Antonio, TX

2008-present

Professor of Surgery, The University of Texas Medical School at Houston, Houston, TX

2008-present

Chief, Division of Acute Care Surgery, Memorial Hermann Hospital, Texas Medical Center, Houston, TX

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Holcomb, J.B. CV March 2013

ACADEMIC APPOINTMENTS (CONTINUED): 2008-present

Director, Center for Translational Injury Research, The University of Texas Medical School at Houston, Houston, TX

2010-present

Vice Chair, Department of Surgery The University of Texas Medical School at Houston, Houston, TX

ADMINISTRATIVE AND U.S. ARMY EXPERIENCE: 1986-1987

Commander and General Medical Officer, U.S. Army Health Clinic, Sinop, Turkey

1991-1994

Chairman, Critical Care Committee, Womack Army Medical Center, Ft. Bragg, NC

1994-1997

Medical Student Coordinator, General Surgery Service, William Beaumont Army Medical Center, El Paso, TX

1994-1997

Institutional Review Board (IRB) and Institutional Animal Care and Use Committee, William Beaumont Army Medical Center, El Paso, TX

1995-1997

Tumor Board Chairman, William Beaumont Army Medical Center, El Paso, TX

1997-1999

IRB, Institute of Surgical Research, Ft. Sam Houston, TX

1997-1999

Chief, Military Trauma Research Branch, U.S. Army Institute of Surgical Research, Ft. Sam Houston, TX

1999-2001

IRB, Baylor College of Medicine and Affiliated Hospitals, Houston, TX

2001-present

Member, Committee for Tactical Combat Casualty Care, U.S. Specials Operations Command, Department of Defense

2002-2006

Co-Chair-Trauma, NIH Resuscitation Outcomes Consortium (ROC)

2002-2008

Commander, United States Army Institute of Surgical Research, Ft Sam Houston, TX

2002-2008

Trauma Consultant for the Army Surgeon General,

2002-2008

Brooke Army Medical Center Hospital Executive Council, Ft. Sam Houston, TX

2003-2007

Board of Directors, Trauma Institute of San Antonio, TX (TRISAT) 3

Holcomb, J.B. CV March 2013

ADMINISTRATIVE AND U.S. ARMY EXPERIENCE (CONTINUED): 2004-2008

Novo Nordisk Phase 3 Prospective, Randomized rFVIIa Trauma Trial Steering Committee

2009

Technical Expert Panel, Vanderbilt EPC Systematic Evidence Review on Traumatic Brain Injury and Depression

2009-2011

Chair, Trauma and Injury Subcommittee, Defense Health Board Committee

2009-2011

Member, Trauma and Injury Subcommittee, Defense Health Board

2010-present

Member, UTHealth Research Committee

2010-present

Member, Memorial Hermann Hospital Surgeons Council

2010-present

Member, Memorial Hermann Hospital Transfusion Committee

2012-present

Member, UTHealth Curriculum Committee

2012-present

Chair, Memorial Hermann Hospital Acute Care Surgery Clinical Practice Committee

LICENSURE: 1985

Arkansas Medical License, #C-6838 (voluntary inactive status)

1998

Texas Medical License # K6604 (28 Feb 2012)

BOARD CERTIFICATION: 1992

American Board of Surgery #337762

2002

American Board of Surgery Recertification (1 July 2013)

2004

American Board of Surgery, Surgical Critical Care, #2123, (1 July 2015)

PROFESSIONAL ORGANIZATIONS: NATIONAL: 1985-present

Member, American Medical Association

1990-present

Fellow, Southwestern Surgical Congress

1991-present

Fellow, American College of Surgeons 4

Holcomb, J.B. CV March 2013

PROFESSIONAL ORGANIZATIONS: NATIONAL (CONTINUED): 2000-present

Member, Association of Military Surgeons of the US

2000-present

Member, Special Operations Medical Association

2000-present

Member, Eastern Association for the Surgery of Trauma

2001-present

Member, American Association for the Surgery of Trauma

2001-present

Member, Disaster and Medical Special Operations Committee, Eastern Association for the Surgery of Trauma

2002-present

Member, American Burn Association

2003-present

Member, Society of Critical Care Medicine

2003-2006

Member, Multi-institutional Trials Committee, American Association for the Surgery of Trauma (AAST)

2004-present

Member, Western Trauma Association

2005-2008

Co-Chair, Military Committee, AAST

2005-present

Member, Shock Society

2006-2009

Member, Program Committee, AAST

2006-2009

Member, Scholarship Committee, Eastern Association for the Surgery of Trauma

2006-present

Member, Multi-Institutional Trials Committee, Western Trauma Association

2007-present

Member, American Surgical Association

2007-present

Board of Directors, National Trauma Institute, (NTI)

2007-present

Member, Committee on Trauma, American College of Surgeons

2007-2010

Member, Scholarship Committee, American College of Surgeons

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Holcomb, J.B. CV March 2013

REGIONAL & LOCAL ORGANIZATIONS: 2001-present

Member, Houston Surgical Society

2009-present

Texas EMS Trauma and Acute Care Foundation, Advisory Committee

2010-present

Member, Arkansas Alpha Chapter of Alpha Omega Alpha

2010-present

Member, SouthEast Texas Regional Advisory Council (SETRAC)

2010-present

Co-Chair, Trauma Committee SETRAC

HONORS AND AWARDS: 1980

Analytical Chemist of the Year

1981

President, Alpha Epsilon Delta (Pre-Medical Society)

1982

Baccalaureate Graduation Honors

2001

“A” Designator in Military Surgery

2001

Order of Military Medical Merit

2004

The Fitts Lecture: Current Perspective on Combat Casualty Care

2004

U.S. Army’s Greatest Inventions Program for the Chitosan Hemostatic Dressing

2004

Honorary Medal for Combat Surgical Care (AAST)

2005

U.S. Army’s Greatest Invention for the Combat Application Tourniquet

2005

Department of the Army Research and Development Achievement Award for Leadership Excellence

2006

Award from the Non-Atomic Military Research and Development (NAMRAD), Principals of the Technical Cooperation Program (TTC) for the Small-Volume Hypertonic Fluid Resuscitation for Hemorrhagic Casualty Care, HUMTP-12

2007

U.S. Army’s Greatest Invention for Damage Control Resuscitation

2008

Lifetime Achievement Award in Trauma Resuscitation Science, American Heart Association

2008

The United States Special Operations Command Medal

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Holcomb, J.B. CV March 2013

HONORS AND AWARDS (CONTINUED): 2008

Service award from the American College of Surgery-Committee on Trauma for outstanding scientific contributions to the surgery of trauma and dedication to the care of wounded warriors.

2009

The University of Texas Chancellor’s Health Fellow for Trauma and Injury

2011

Dr. C. Frank Webber Medical Student Research Forum, First Place, Mentor

MILITARY AWARDS/DECORATIONS: 1985-2008: Joint Meritorious Unit Award (2nd Award) Army Superior Unit Award Combat Medical Badge Bronze Star Legion of Merit Defense Meritorious Service Medal Meritorious Service Medal (3rd oak leaf cluster) Joint Services Commendation Medal Army Commendation Medal (1st oak leaf cluster) Joint Services Achievement Medal (1st oak leaf cluster) National Defense Service Medal Army Achievement Medal Armed Forces Expeditionary Medal Army Service Ribbon Overseas Ribbon

EDITORIAL POSITIONS Ad Hoc Reviewer: Journal of Trauma: Injury, Infection and Critical care Journal of Anesthesiology Critical Care Medicine Journal of the American Medical Association Journal of the American College of Surgeons Blood Coagulation & Fibrinolysis Annals of Surgery Vox Sanguinis Lancet European Journal of Anesthesiology Surgery British Journal of Surgery Archives of General Psychiatry

European Journal of Emergency Medicine Journal of Intensive Care Medicine Archives of Surgery PLoS ONE Thrombosis Research Resuscitation Science Symposium, American Heart Association Molecular Medicine Editorial Board: Trauma World Journal of Emergency Surgery Journal of Trauma: Injury, Infection and Critical Care. Section Editor for Military Trauma

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Holcomb, J.B. CV March 2013

RESEARCH MENTOR: James Cole, postdoctoral fellow, 1998 David Kauvar, postdoctoral fellow, 2004-2005 Heather Pidcoke, postdoctoral fellow, 2005-2008 Neil McMullin, postdoctoral fellow, 2005-2006 Joe Kelly, postdoctoral fellow, 2006-2007 Amber Ritenour, postdoctoral fellow, 2006-2007 Jason Edens, postdoctoral fellow, 2007-2008 Kenneth Jastrow, postdoctoral fellow, 2008-2009 Jeremy Ward, postdoctoral fellow, 2008-2009 Peter Walker, postdoctoral fellow, 2008-2010 Shelly Scerbo, predoctoral researcher, 2008 Ricky Haywood-Watson, postdoctoral fellow, 2009-2010 Phil Letourneau, postdoctoral fellow, 2009-2010 Supinder Bedi, postdoctoral fellow, 2010-2011 Eric LeFebvre, research preceptee, 2010-2011 Zeinab Alawadi, postdoctoral researcher, 2010-2011 Hari Radhakrishnan, postdoctoral fellow, 2010-present Adam Wright, predoctoral researcher, 2011 John Harger, predoctoral researcher, 2012

CURRENT GRANT SUPPORT: Mission Connect Mild TBI Translational Research Consortium Co- Investigator US Department of Defense

2008-13 $275,264

Early Whole Blood for Patients Requiring MT after Major Trauma Co-Investigator US Department of Defense

2009-13 $753,274

Hypertonic Saline: Systematic Review of Meta-Analysis of Individual Patient Data Co-Investigator US Department of Defense

2009-13 $255,645

Combat Junctional Body Tourniquet Cadaver Study Principal Investigator North American Rescue Evaluation of Non-Invasive Hemoglobin and Pulse Pressure Variability in Trauma Patients: Clinical Validation of Masimo’s Rainbow SET Handheld Oximeter Principal Investigator Office of Naval Research Pragmatic, Randomized Optimal Platelet and Plasma Ratios Principal Investigator of Clinical Coordinating Center US Department of Defense/NHLBI

2012-13 $44,090

2010-13 $1, 170,340 2010-14 $42,980,640

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Holcomb, J.B. CV March 2013

CURRENT GRANT SUPPORT (CONTINUED): Treatment of Adult Severe Traumatic Brain Injury Using Autologous Bone Marrow Mononuclear Cells Co-Investigator US Department of Defense/AFIRM

2011-2014 $1,722,975

Evaluation of Lyphilized Plasma (LP) in Models of Vascular Injury and Hemorrhagic Shock Co-Investigator US Department of Defense

2011-13 $1,500,000

PAST GRANT SUPPORT: Laparoscopic Hernia Repair with Atrium Mesh Principle Investigator Atrium Medical

1995-96 $5,000

Dry Fibrin Sealant Dressing for Hemorrhage Control after a Ballistic Injury Principle Investigator Special forces Operational Detachment - Delta

1995-96 $5,000

Development and Testing of the Dry Fibrin Sealant Dressing Principal Investigator American Red Cross

1996-97 $50,000

Development and Testing of the Dry Fibrin Sealant Dressing Principal Investigator Joint Special Operations Command

1996-97 $25,000

Development and Testing of the Dry Fibrin Sealant Dressing Principal Investigator USA Medical Research and Material Command

1996-97 $50,000

Development and Testing of the Dry Fibrin Sealant Dressing Principal Investigator USA Medical Research and Material Command

1996-97 $94,000

Development and Testing of the Dry Fibrin Sealant Dressing Principal Investigator USA Medical Research and Material Command

1996-97 $100,000

Optimal Device for Treating Tension Pneumothorax by Combat Medics Principal Investigator Marine Corps Combat Development Command Development and Testing of the Dry Fibrin Sealant Dressing Principal Investigator USA Special Operations Command

1997-98 $75,000

1997-98 $182,000

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Holcomb, J.B. CV March 2013

PAST GRANT SUPPORT (CONTINUED): Development of Testing of a Hemostatic Foam for Hemorrhage Control from Noncompressible Hemorrhage Principal Investigator USA Special Operations Command Evaluation of Fibrin Dressings for Hemorrhage Control in a Simulated Land Mine Injury Co-Principal Investigator American Red Cross Continuous Physiologic Data Acquisition and Analysis Across the Trauma Spectrum Principal Investigator US ARMY MRMC

1997-99 $186,000

1999-2000 $100,000

2000-01 $50,000

Continuous Physiologic Data Analysis after Trauma Principal Investigator US Army MRMC

2001-02 $140,000

Continuous Physiologic Data Analysis after Trauma Principal Investigator DARPA

2001-02 $200,000

Reducing Mortality from Acute Hemorrhage in Trauma Consultant Clinical Research Center Grant (National Transfusion Medicine) TexSHIELD Co-Investigator US Department of Defense/TATRC Prospective Multicenter Transfusion Study in Trauma Patients Co-Investigator US Department of Defense/MRMC Prospective Evaluation of Aeromedial EMS Ultrasound Principal Investigator Sonosite, Inc. Pathogenesis of Multiple Organ Failure Principle Investigator National Institutes of Health/NIGMS 5P50GM038529 Accelerating Early Weight Bearing Segmental Bone Regeneration Co-Investigator Extremity War Trauma Research Foundation

2002-07 $1,490,000

2007-10 $808,111

2008-10 $9,200,000

2009-10 $100,000

2010-11 $162,474/yr

2010-11 $67,500

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Holcomb, J.B. CV March 2013

PAST GRANT SUPPORT (CONTINUED): ABThera Open Abdomen Negative Pressure Therapy Sys/Barker’s Vacuum-Packing Technique Principal Investigator KCI, Inc

2010-12 $255,000

Multicenter study evaluating the use of rapid TEG Co-Investigator Haemonetics, Inc.

2010-11 $560,000

Timing and Mechanism of Traumatic Coagulopathy Co-Investigator National Trauma Institute

2011-2012 $8,613

Characterization and Application of a Large Model of Penetrating Ballistic Brain Injury Co-Investigator US Department of Defense

2011-12 $1,019,999

Comparative Effectiveness of Clinical Care Processes in Resuscitation and Management of Moderate to Severe Traumatic Injuries Co-Investigator National Trauma Institute

2010-2012 $62,222

Validation of the Athena Wireless Vital Signs Monitor Principal Investigator National Trauma Institute

2009-12 $220,000

PUBLICATIONS: 1.

Geer D, Arnaud G, Beitler A, Holcomb JB, et al. Colonic Volvulus. The Army Medical Center Experience 1983-1987. Am J Surg. 1991 May;57(5):295-300. PMID: 2039127.

2.

Hetz SP, Holcomb JB. Combined Laparoscopic Exploration and Repair of Inguinal Hernias. J Am Coll Surg. 1996 Apr:364-366. PMID: 8605561.

3.

Holcomb JB, Pusateri AE, Hetz SP, Harris RA, Hess JR, MacPhee MJ, Tock BB, Drohan WN. Implications of New Fibrin Sealant Technology for Trauma Surgery. Surg Clin North Am. 1997 Aug;77(4):943-52. PMID: 9291993.

4.

Holcomb JB, Pusateri A, MacPhee M, Hess J. New Technologies in Hemorrhage Control. Curr Opin Crit Care. 1997;3:488-93.

5.

Holcomb JB, MacPhee M, Hetz S, et al. Efficacy of a Dry Fibrin Sealant Dressing for Hemorrhage Control after a Ballistic Injury. Arch Surg. 1998 Jan;133(1):32-35. PMID: 9438755.

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Holcomb, J.B. CV March 2013

PUBLICATIONS (CONTINUED): 6.

Tock B, Drohan W, Hess J, Pusateri A, Holcomb JB, MacPhee M. Hemophilia and advanced fibrin sealant technologies. Hemophilia. 1998 Jul;4:449-455. PMID: 9873774.

7.

Holcomb JB, Pusateri AE, Harris RA, Charles NC, Gomez RR, Cole JP, Beall Ld, Bayer V, MacPhee MJ, Hess JR. Effect of Dry Fibrin Sealant Dressings Versus Gauze Packing on Blood loss in Grade V Liver Injuries in Resuscitated Swine. J Trauma. 1999 Jan;46(1);46-57. PMID: 9932683.

8.

Lein B, Holcomb JB, Brill S, Hetz SP, McCrorey T. Removal of unexploded ordnance from patients: a 50 year military experience and current recommendations. Mil Med. 1999 Mar;164(3):163-65. PMID: 10091487.

9.

Nessen SC, Holcomb JB, Tonkinson B, Hetz SP, Schreiber MA. Early laparoscopic Nissen fundoplication for recurrent reflux esophagitis: A cost-effective alternative to omeprazole. JS Laparoendoscopic Surgeons. 1999 Apr-Jun;3(2):103-106. PMID: 10444007 PMCID: PMC3015328.

10.

Holcomb JB, Pusateri AE, Harris RA, Reid TJ, Beall LD, Hess JR, MacPhee MJ. Dry fibrin sealant dressings reduce blood loss, resuscitation volume and improve survival in hypothermic coagulopathic swine with grade V liver injuries. J Trauma. 1999 Aug;47(2):233-40; discussion 240-2. PMID: 10452456.

11.

Holcomb JB, Pusateri AE, Baskin TW, Ellison RW, Macaitis JM, Brinkley WW, Sondeen JL. Hemodynamic and metabolic effects of resuscitation in an uncontrolled hemorrhage model of severe rat liver injury. Current Surgery. 1999;56(7/8):423-427.

12.

Martin RR, Alvarez J, Holcomb JB. Civilian urban trauma experience approximates injuries seen in war for abdominal injuries. Current Surgery. 1999;56(7/8):417-419

13.

Butler FK, Hagmann JH, Holcomb JB, et al. Tactical Management of Urban Warfare Casualties in Special Operations. Mil Med. 2000 Apr;165 (4, supp:1-48). PMID: 10803010.

14.

Dubick MA, Holcomb JB. A review of intraosseous vascular access: Current status and military application. Mil Med. 2000 Jul;165(7):552-59. PMID: 10920658.

15.

Holcomb JB, McClain JM, Beall LD, Pusateri AE, Macaitis JM, Harris RA, MacPhee MJ, Hess JR. Fibrin Sealant Foam Sprayed Directly On Liver Injuries Decreases Blood Loss in Resuscitated Rats. J Trauma. 2000 Aug;49(2):246-50. PMID: 10963535.

16.

Cornum RL, Morey AF, Harris R, Gresham V, Daniels R, Knight RW, Beall D, Pusateri A, Holcomb JB, MacPhee M. Does the absorbable fibrin adhesive bandage facilitate partial Nephrectomy? J Urol. 2000 Sep;164(3 Pt 1):864-7. PMID: 10953169.

12

PUBLICATIONS (CONTINUED):

Holcomb, J.B. CV March 2013

17.

Mabry RL, Holcomb JB, Baker AM, Uhorchak JM, Cloonan CC, Canfield AJ, Perkins DE, Hagmann JH. US Army Rangers in Somalia: An analysis of combat casualties on an urban battlefield. J Trauma. 2000 Sep;49(3):515-28; discussion 528-9. PMID: 11003332.

18.

Aoki N, Wall MJ, Granchi T, Schreiber MA, Holcomb JB, Byrne M, Liscum KR, Goodwin G, Demsar J, Zupan B, Beck JR, Mattox KL. Predictive Model For Survival At The Conclusion Of A Damage Control Laparotomy. Am J Surg. 2000 Dec;180(6):540-45; discussion 544-5. PMID: 11182414.

19.

Pusateri AE, Holcomb JB, Bhattacharyya SN, Harris RA, Gomez RR, MJ MacPhee, JI Enriquez, AV Delgado, NC Charles, JR Hess. Different Hypotensive Responses To Intravenous Bovine And Human Thrombin Preparations In Swine. J Trauma. 2001 Jan;50(1):83-90. PMID: 11231675.

20.

Pusateri AE, Holcomb JB, Harris RA, MacPhee MJ, Charles NC, Beall LD, Hess JR. Effect of Fibrin Bandage Fibrinogen Concentration on blood Loss after grade V liver injury in swine. Mil Med. 2001 Mar:166(3):217-222. PMID: 11263022.

21.

Martinowitz U, Holcomb JB, Pusateri AE, Stein M, Onaca N, Freidman M, Macaitis JM, Castel D, Hedner U, Hess JR. Intravenous rFVIIa Administered for Hemorrhage Control in Hypothermic Coagulopathic Swine with Grade V Liver Injuries. J Trauma. 2001 Apr:50(4);721-729. PMID: 11303171.

22.

Hirshberg A, Holcomb JB, Mattox KL. Hospital Trauma Care in Multiple Casualty Incidents: A Critical view. Ann Emerg Med. 2001 Jun;37(6):647-52. PMID: 11385336.

23.

Holcomb JB, Hirshberg A, Helling TS. Military, Civilian, and Rural Application of the Damage Control Philosophy. Mil Med. 2001 Jun;166(6):490-493. PMID: 11413725.

24.

Kheirabadi BS, Tuthill D, Bayer V, Pearson R, Hill CR, Beall D, Drohan B, MacPhee MJ, Holcomb JB. Metabolic and hemodynamic effects of CO2 pneumoperitoneum in a controlled hemorrhage model. J Trauma. 2001 Jun;50(6):1031-43. PMID: 11426117.

25.

Holcomb JB, Champion HR. Military Damage Control. Arch Surg. 2001 Aug;136(18):965-7. PMID: 11485541.

26.

McHenry T, Simmons S, Alitz C, Holcomb JB. Forward surgical stabilization of penetrating lower extremity fractures: Circular casting versus external fixation. Mil Med. 2001 Sept:166(9):791-95. PMID: 11569443.

27.

Wall MJ, Hirshberg A, LeMaire SA, Holcomb JB, Mattox KL. Thoracic aortic and thoracic vascular injuries. Surg Clin N Amer. 2001 Dec;81(6);1375-94. PMID: 11766181.

28.

Roberts DA, Holcomb JB, Parker BE, Sondeen JL, Pusateri AE, Brady WJ, Young JS. The use of polynomial neural networks for mortality prediction in uncontrolled venous and arterial hemorrhage. J Trauma. 2002 Jan;52:130-5. PMID: 11791063.

13

PUBLICATIONS (CONTINUED):

Holcomb, J.B. CV March 2013

29. Crommett JW, McCabe D, Holcomb JB. Training for the transport of mechanically ventilated patients. Respir Care Clin N Am. 2002 Mar;8(1):105-18. PMID; 12184654. 30. Carrico CJ, Holcomb JB, Chaudry IH. PULSE Trauma Work Group. Scientific priorities and strategic planning for resuscitation research and life saving therapy following traumatic injury: Report of pulse trauma work group. Post Resuscitative and Initial Utility of Life Saving Efforts. Shock. 2002 Mar;17(3):165-8. PMID: 11900332. 31. Schreiber MA, Holcomb JB, Conaway CW, Campbell KD, Wall M, Mattox KL. Military trauma training performed in a civilian trauma center. J Surg Res. 2002 May; 104(1):8-14. PMID: 11971671. 32. Holcomb JB, Dumire RD, Crommett JW, Stamateris CE, Fagert MA, Cleveland JA, Dorlac GR, Dorlac WC, Mattox KL. Evaluation of Trauma Team. Performance Using An Advanced Human Patient Simulator For Resuscitation Training. J Trauma. 2002 Jun;52(6):1078-1085; discussion 1085-6. PMID; 12045633. 33. Kheirabadi B, Pearson R, Tuthill D, Rudnicka K, Drohan W, Holcomb JB, MacPhee MJ. Comparative Study of the Hemostatic efficacy of a new human fibrin sealants: Is an antifibrinolytic agent necessary? J Trauma. 2002 Jun;52(6):1107-15. PMID; 12045638. 34.

Carrico CJ, Holcomb JB, Chaudry IH; PULSE Trauma Work Group. Post Resuscitative and Initial Utility of Life Saving Efforts. Scientific Priorities and Strategic Planning for Resuscitation Research and Life Saving Therapy Following Traumatic Injury: Report of the PULSE Trauma Work Group. Acad Emerg Med. 2002 Jun;9(6):621-6. PMID: 12045079.

35.

Schreiber MA, Holcomb JB, Hedner U, Brundage SI, Macaitis JM, Hoots K. The effect of recombinant factor VIIa on coagulopathic pigs with grade V liver injuries. J Trauma. 2002 Aug;53(2):252-7; discussion 257-9. PMID: 12169930.

36.

McHenry TP, Holcomb JB, Aoki N, Lindsey RW. Fractures With Major Vascular Injuries from Gunshot Wounds: Implications of surgical sequence. J Trauma. 2002 Oct;53(4):717-21. PMID: 12394872.

37.

Balogh Z, McKinley BA, Cocanour CS, Kozar RA, Holcomb JB, Ware DN, Moore FA. Secondary Abdominal Compartment Syndrome is an Elusive Early Complication of Traumatic Shock Resuscitation. Am J Surg. 2002 Dec;184(6):538-43;discussion 543-4. PMID: 12488160.

38.

Sondeen JL, Pusateri AE, Coppes VG, Gaddy CC, Holcomb JB. Comparison of 10 different Hemostatic Dressings in an Aortic Injury. J Trauma. 2003 Feb;54(2):280-5. PMID: 12579052.

39.

Holcomb JB, McMullin NR, Kozar RA, Lygas MH, Moore FA. Morbidity From Rib Fractures Increases After Age 45. J Am Coll Surg. 2003 Apr;196(4):549-55. PMID: 12691929.

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PUBLICATIONS (CONTINUED):

Holcomb, J.B. CV March 2013

40.

Schreiber MA, Holcomb JB, Hedner U, Brundage SI, Macaitis JM, Aoki N, Meng ZH, Tweardy DJ, Hoots K. The Effect of Recombinant Factor VIIa on Noncoagulopathic Pigs With Grade V Liver Injuries. J Am Coll Surg. 2003 May;196(5):691-7. PMID: 12742197.

41.

Holcomb JB. Fluid Resuscitation in Modern Combat Casualty Care: Lessons Learned From Somalia. J Trauma. 2003 May;54(5 Suppl):S46-51. PMID: 12768103.

42.

Sondeen JL, Coppes VG, Holcomb JB. Blood Pressure at which Rebleeding Occurs after Resuscitation in Swine with Aortic Injury. J Trauma. 2003 May;54(5, Suppl):S110-17. PMID: 12768112.

43.

Balogh Z, McKinley BA, Holcomb JB, Miller CC, Cocanour CS, Kozar RA,Valdivia A, Ware DN, Moore FA. Both Primary and Secondary Abdominal Compartment Syndrome Can Be Predicted Early and are Harbingers of Multiple Organ Failure. J Trauma. 2003 May;54(5):848-57; discussion 859-61. PMID: 12777898.

44.

Bruce S, Bridges EJ, Holcomb JB. Preparing to respond: Joint Trauma Training Center and USAF Nursing Warskills Simulation Laboratory. Crit Care Nurs Clin North Am. 2003 Jun;15(2):149-62. PMID: 12755181.

45.

Holcomb JB, Neville HL, Fischer CF, Hoots K. Use of Recombinant FVIIa for Intraperitoneal Coagulopathic Bleeding in a Septic Patient. Current Surgery. 2003 Jul-Aug;60(4): 423-7. PMID: 14972234.

46.

Brundage SI, Schreiber MA, Holcomb JB, Zautke N, Mastrangelo MA, Xq X, Macaitis J, Tweardy DJ. Amplification of the Proinflammatory Transcription Factor Cascade Increases With Severity of Uncontrolled Hemorrhage in Swine. J Surg Res. 2003 Jul;113(1):74-80. PMID: 12943813.

47.

Pusateri AE, Modrow HE, Harris RA, Holcomb JB, Hess JR, Mosebar RH, Reid TJ, Nelson JH, Goodwin CW, Fitzpatrick GM, McManus AT, Zolock DT, Sondeen JL, Cornum RL, Martinez RS. Advanced Hemostatic Dressing Development Program: Animal Model Selection Criteria and Results of a Study of Nine Hemostatic Dressings in a Model of Severe Large Venous Hemorrhage and Hepatic Injury in Swine. J Trauma. 2003 Sep; 55(3):518-26. PMID: 14501897.

48.

Holcomb JB. Methods for Improved Hemorrhage Control. Critical Care. 2004;8(Suppl 2):S57-S60. PMID: 15196327.

49. Kozar RA, Holcomb JB, Hassoun HT, Macaitis J, DeSoignie R, Moore FA. Superior Mesenteric Artery Occlusion Models Shock-Induced Gut Ischemia- Reperfusion: Models Of Shock-Induced Gut Ischemia. J Surg Res. 2004 Jan; 116(1):145-50. PMID: 14732361. 50.

Pusateri AE, Kheirabadi BS, Delgado AV, Doyle JW, Kanellos J, Uscilowics JM, Martinez RS, Holcomb JB, Modrow HE. Structural Design of the Dry Fibrin Sealant Dressing and Its Impact on the Hemostatic Efficacy of the Product. J Biomed Mater Res. 2004 Jul 15;70B(1):114-21. PMID: 15199591.

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PUBLICATIONS (CONTINUED):

Holcomb, J.B. CV March 2013

51.

Sondeen JL, Pusateri AE, Hedner U, Yantis LD, Holcomb JB. Recombinant Factor VIIa Increases the Pressure at which Rebleeding Occurs in Procine Uncontrolled Aortic Hemorrhage Model. Shock. 2004 Aug;22(2):163-8. PMID: 15257090.

52.

Kotwal RS, O’Connor KC, Johnson TR, Mosely DS, Meyer DE, Holcomb JB. A Novel Pain Management Strategy for Combat Casualty Care. Ann Emerg Med. 2004 Aug;44(2):121-7. PMID: 15278083.

53.

Hoyt DB, Holcomb JB, Abraham E, Atkins J, Sopko G. Working Group on Research Program Summary Report: National Heart Lung Blood Institute (NHLBI), National Insistute of Gerneral Medical Science (NIGMS), and National Institute of Neurological disorders and Stroke (NINDS) of the National Institutes of Health (NIH), and the Department of Defense (DoD). J Trauma. 2004 Aug; 57(2):410-15. PMID: 15345998.

54.

Zhang JN, Wood J. Bergeron AL, McBride L, Ball C, Yu Q, Pusateri AE, Holcomb JB, Dong J. Effects of Low Temperature on Shear-induced Platelet Aggregation and Activation. J Trauma. 2004 Aug;57(2):216-23. PMID: 15345964.

55.

Pusateri AE, Delgado AV, Dick EJ Jr, Martinez RS, Holcomb JB, Ryan KL. Application of a granular mineral-based hemostatic agent (QuikClot) to reduce blood loss after grade V liver injury in swine. J Trauma. 2004 Sep;57(3):555-62; discussion 562. PMID: 15454802.

56.

Brundage SI, Zautke NA, Holcomb JB, Spain DA, Lam JC, Mastrangelo MA, Macaitis JM, Tweardy DJ. Interleukin-6 infusion blunts proinflammatory cytokine production without causing systematic toxicity in a swine model of uncontrolled hemorrhagic shock. J Trauma. 2004 Nov; 57(5)970-7, discussion 977-8. PMID: 15580019.

57.

Lurie KG, Idris A, Holcomb JB. Level 1 Cardiac Arrest Centers: Learning from the Trauma Surgeons. Acad Emer Med. 2005 Jan;12(1):79-80. PMID: 15635142.

58.

Holcomb JB, Niles SE, Miller CC, Hinds D, Duke JH, Moore FA. Pre-hospital Physiologic Data and Lifesaving Interventions in Trauma Patients. Mil Med. 2005 Jan;170(1):7-13. PMID: 15724847.

59.

Dubick MA, Brooks DE, Macaitis JM, Bice TG, Moreau AR, Holcomb JB. Evaluation of Commercially Available Fluid-Warming Devices for Use in Forward Surgical and Combat Areas. Mil Med. 2005 Jan;170(1):76-82. PMID: 15724859.

60.

Kirkpatrick AW, Campbell MR, Jones JA, Broderick TJ, Ball CG, McBeth PB, McSwain NE, Hamilton DR, Holcomb JB. Extraterrestrial hemorrhage control: terrestrial developments in technique, technology, and philosophy with applicability to traumatic hemorrhage control in long-duration space flight. J Am Coll Surg. 2005 Jan;200(1):64-76. PMID: 15631922.

61.

Mohr Am, Holcomb JB, Dutton RP, Duranteau J. Recombinant Activated Factor VIIa and Hemostatis in Critical Care: a Focus on Trauma. Crit Care. 2005;9 Suppl 5:S37-42. PMID; 16221318. 16

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62.

Schreiber MA, Holcomb JB, Rojkjaer R. Preclinical Trauma studies of Recombinant Factor VIIa. Crit Care. 2005;9 Suppl 5:S25-8. PMID: 16221316.

63.

Wojcik BE, Stein CR, Devore RB Jr., Hassell LH, Holcomb JB. Status of Trauma Care in U.S. Army Hospitals. Mil Med. 2005 Feb;170(2):141-8. PMID: 15782836.

64.

Barillo DJ, Jordan MH, Jocz RJ, Nye D, Cancio LC, Holcomb JB. Tracking the Daily Availability of Burn Beds for National Emergencies. J Burn Care Rehabil. 2005 Mar-Apr; 26(2):174-82. PMID: 15756121.

65.

Mozingo DW, Barillo DJ, Holcomb JB. The Pope Air Force Base Aircraft Crash and Burn Disaster. J Burn Care Rehabil. 2005 Mar-Apr;26(2):132-40. PMID: 15756114.

66.

Barillo DJ, Cancio LC, Hutton BG, Gueller GE, Holcomb JB. Combat Burn Life Support: A Military Burn Education Program. J Burn Care Rehabil. 2005 Mar-Apr;26(2):162-5. PMID: 15756118.

67.

Cancio LC, Horvath EE, Barrillo DJ, Kopchinski BJ, Charter KR, Montalvo AE, Buescher TM, Brengman ML, Brandt MM, Holcomb JB. Burn Support for Operation Iraqi Freedom and Related Operations, 2003 to 2004. J Burn Care Rehabil. 2005 Mar-Apr;26(2):151-61. PMID: 15756117.

68.

Holcomb JB, Hoots K, Moore FA. Treatment of an Acquired Coagulopathy with Recombinant Activated Factor VII in a damage-control Patient. Mild Med. 2005 Apr;170(4):287-90. PMID: 15916295.

69.

Butler F, Holcomb JB. The Tactical Combat Casualty Care Transition Initiative. Army Medical Department Journal. 2005 Apr pp33-37.

70.

Martini WZ, Pusateri AE, Usciliowicz JM, Delgado AV, Holcomb JB. Independent Contributions of Hypothermia and Acidosis to Coagulopathy in Swine. J Trauma. 2005 May;58(5):1002-9; discussion 1009-10. PMID: 15920416.

71.

Holcomb JB. Use of Recombinant Activated Factor VII to Treat the Acquired Coagulopathy of Trauma. J Trauma. 2005 Jun;58(6):1298-303. Review. PMID: 15995488.

72.

Klemcke HG, Delgado A, Holcomb JB, Ryan KL, Burke A, DeGuzman R, Scherer M, Cortez D, Uscilowicz J, Macaitis JM, Bliss J, Wojtaszczyk J, Christensen S, Currier H, Pusateri AE. Effect of Recombinant FVIIa in Hypothermic, Coagulopathic Pigs with Liver Injuries. J Trauma. 2005 Jul;59(1):155-61; discussion 161. PMID: 16096556.

73.

Kheirabadi BS, Acheson EM, DeGuzman R, Sondeen JL, Ryan KL, Delgado A, Dick EJ Jr, Holcomb JB. Hemostatic Efficacy of Two Advanced Dressings in an Aortic Hemorrhage Model In Swine. J Trauma. 2005 Jul;59(1):25-34, discussion 34-5. PMID: 16096535.

74.

Wade CE, Holcomb JB. Endpoints in Clinical Trials of Fluid Resuscitation of Patients with Traumatic Injuries. Transfusion. 2005 Jul;45 Suppl:4S-8S. Review. PMID: 15989685. 17

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75.

Dorlac WC, DeBakey ME, Holcomb JB, Fagan SP, Kwong Kl, Dorlac GR, Schreiber MA, Persee DE, Moore FA , Mattox K. Mortality from Isolated Civilian Penetrating Extremity injury. J Trauma. 2005 Jul;59(1):217-22. PMID: 16096567.

76.

Acheson EM, Kheirabadi BS, Deguzman R, Dick EJ Jr, Holcomb JB. Comparison of Hemorrhage Control Agents Applied to Lethal Extremity Arterial Hemorrhages in Swine. J Trauma. 2005 Oct;59(4):865-74; discussion 874-5. PMID:16374275.

77.

Holcomb JB, Salinas J, McManus JM, Miller CC, Cooke WH, Convertino VA. Manual Vital Signs Reliably Predict need for Life-saving Interventions in Trauma Patients. J Trauma. 2005 Oct;59(4):821-9; discussion 828-9. PMID: 16374268.

78.

McManus J, Yershov AL, Ludwig D, Holcomb JB, Salinas J, Dubick MA, Convertino VA, Hinds D, David W, Flanagan T, Duke JH. Radial Pulse Character Relationships to Systolic Blood Pressure and Trauma Outcomes. Prehosp Emerg Care. 2005 Oct-Dec;9(4):423-8. PMID: 16263676.

79.

Walters TJ, Wenke JC, Kauvar DS, McManus JG, Holcomb JB, Baer DG. Effectiveness of Self-applied Tourniquets in Human Volunteers. Prehosp Emerg Care. 2005 Oct-Dec;9(4):416-22. PMID: 16263675.

80.

Kozar RA, Moore JB, Niles SE, Holcomb JB, Moore EE, Cothren CC, Hartwell E, Moore FA. Complications of Nonoperative Management of High-Grade Blunt Hepatic Injuries. J Trauma. 2005 Nov;59(5):1066-1071. PMID: 16385280.

81.

Holcomb JB. The 2004 Fitts Lecture: Current Perspective on Combat Casualty Care. J Trauma. 2005 Nov;59(4):990-1002. PMID: 16374293.

82.

Martini WZ, Chinkes DL, Pusateri AE, Holcomb JB, Yu YM, Zhang XJ, Wolfe RR. Acute Changes in Fibrinogen Metabolism and Coagulation after Hemorrhage in Pigs. AM J Physiol Endocrinol Metab. 2005 Nov; 289(5). PMID: 15956050.

83.

Cooke WH, Salinas J, Convertino VA, Ludwig DA, Hinds D, Duke JH, Moore FA, Holcomb JB. Heart rate variability and its association with mortality in prehospital trauma Patients. J Trauma. 2006 Feb:60(2):363-70; discussion 370. PMID: 16508497.

84.

Holcomb JB, Stansbury LG, Champion HR, Wade C, Bellamy RF. Understanding Combat Casualty Care Statistics. J Trauma. 2006 Feb;60(2):397-401. PMID: 16508502.

85.

Pusateri AE, Holcomb JB, Kheirabadi BS, Alam HB, Wade CE, Ryan KL. Making Sense of the Preclinical Literature on Advanced Hemostatic Products. J Trauma. 2006 Mar;60(3):674-82. PMID: 16531876.

86.

Wedmore I, McManus JG, Pusateri AE, Holcomb JB. A Special Report on the Chitosan-Based Hemostatic Dressing: Experience in Current Combat Operations. J Trauma. 2006 Mar;60(2):655-8. PMID: 16531872. 18

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87.

Kozar RA, Moore FA, Cothren CC, Moore EE, Sena M., Bulger EM, Miller CC, Eastridge B, Acheson E, Brundage SI, Tataria M, McCarthy M, Holcomb JB. Risk Factors for Hepatic Morbidity Following Nonoperative Management: Multicenter Study. Arch Surg. 2006 May;141(5):451-8; discussion 458-9. PMID: 16702516.

88.

Hess JR, Holcomb JB, Hoyt DB. Damage Control Resuscitation: The Need for Specific Blood Products to Treat the Coagulopathy of Trauma. Transfusion. 2006 May:46(5):685-6. PMID: 16686833.

89.

Kauvar DS, Cancio LC, Wolf SE, Wade CE, Holcomb JB. Comparison of Combat and Non-combat Burns from Ongoing U.S. Military Operations. J Surg Res. 2006 May 15; 132(2):196-200. PMID: 16580688.

90.

Cancio LC, Galvez E Jr, Turner CE, Kypreos NG, Parket A, Holcomb JB. Base Deficit and AlveolarArterial Gradient during Resuscitation Contribute Independently but Modestly to the Prediction of Mortality After Burn Injury. J Burn Care Res. 2006 May-Jun;27(3):280-96. PMID: 16679895.

91.

Ciraulo DL, Barie PS, Briggs SM, Bjerke HS, Born CT, Capella J, Cancio L, Dennis A, Digiacomo JC, Gross RI, Hammond JS, Holcomb JB, Jenkins D, Knuth TE, Letarte PB, Lynn M, O’Neill PA, Salomone JP, Shatz DV. An Update on the Surgeons Scope and Depth of Practice to all Hazards Emergency Response. J Trauma. 2006 Jun;60(6):1267-74. PMID: 16766970.

92.

Eastridge BJ, Malone D, Holcomb JB. Early Predictors of Transfusion and Mortality After Injury: A Review of the Data-Based Literature. J Trauma. 2006 Jun;60(6 Suppl):S20-S25. PMID: 16763476.

93.

Holcomb JB, Hess JR. Early Massive Trauma Transfusion: State of the Art: Editors’ Introduction. J Trauma. 2006 Jun;60(6Supple):S1-2.

94.

Wolf SE, Kauvar DS, Wade CE, Cancio LC, Renz EP, Horvath EE, White CE, Park MS, Wanek S, Albrecht MA, Blackbourne LH, Barillo DJ, Holcomb JB. Comparison Between Civilian Burns and Combat Burns from Operation Iraqi Freedom and Operation Enduring Freedom. Ann Surg. 2006 Jun;243(6):786-92; discussion 792-5. PMID: 16772782, PMCID: PMC1570579.

95.

Holcomb JB, Kheirabadi BS, Wade CE. Letters to the Editor. J Trauma. 2006 Jul:61(1):241.

96.

Kauvar DS, Holcomb JB, Norris GC, Hess Jr. Fresh whole blood transfusion: a Controversial military practice. J Trauma. 2006 Jul;61(1):181-4. PMID: 16832268.

97.

Martini WZ, Dubick MA, Pusateri AE, Park MS, Ryan KL, Holcomb JB. Does bicarbonate correct coagulation function impaired by acidosis in Swine? J Trauma. 2006 Jul;61(1):99-106. PMID: 16832255.

98.

McMullin NR, Kauvar DS, Currier HM, Baskin TW, Pusateri AE, Holcomb JB. The Clinical and Laboratory Response to Recombinant Factor VIIa in Trauma and Surgical Patients with Acquired Coagulopathy. Curr Surg. 2006 Jul-Aug:634:246-51. PMID: 16843774.

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PUBLICATIONS (CONTINUED): 99.

Holcomb, J.B. CV March 2013

Convertino VA, Cooke WH, Holcomb JB. Arterial Pulse Pressure and its Association with Reduced Stroke Volume during Progressive Central Hypovolemia. J Trauma. 2006 Sep;61(3):629-34. PMID: 16966999.

100. White CE, Schrank AE, Baskin TW, Holcomb JB. Effects of Recombinant Activated Factor VII in Traumatic Nonsurgical Intracranial Hemorrhage. Curr Surg. 2006 Sep-Oct;63(5):310-7. PMID: 16971200. 101. Chung KK, Blackbourne LH, Wolf SE, White CE, Renz EM, Cancio LC, Holcomb JB, Barillo DJ. Evolution of Burn Resuscitation in Operation Iraqi Freedom. J Burn Care Res. 2006 Sep-Oct;27(5)606-11. PMID: 16998392. 102. Eastridge BJ, Owsley J, Sebesta J, Beekley A, Wade C, Wildzunas R, Rhee P, Holcomb JB. Admission Physiology Criteria After Injury on the Battlefield Predict Medical Resource Utilization and Patient Mortality. J Trauma. 2006 Oct: 61(4):820-823. PMID: 17033546. 103. Albrecht MA, Griffith ME, Murray CK, Chung KK, Horvath EE, Ward JA, Hospenthal DR, Holcomb JB, Wolf SE. Impact of Acinetobacter Infection on the Mortality of Burn Patients. J Am Coll Surg. 2006 Oct;203(4):546-50. PMID: 17000400. 104. McManus JG, Convertino VA, Cooke WH, Ludwig DA, Holcomb JB. R-wave Amplitude in Lead II of an Electrocardiograph Correlates with Central Hypovolemia in Human Beings. Acad Emerg Med. 2006 Oct;13(10):103-10. PMID: 16973639. 105. Cooke WH, Salinas J, McManus JG, Ryan KL, Richards CA, Holcomb JB, Convertino VA. Heart Period Variability in Trauma Patients May Predict Mortality and Allow Remote Triage. Aviat Space Environ Med. 2006 Nov;77(11):1107-12. PMID: 17086761. 106. Kauvar DS, Wolf SE, Wade CE, Cancio LC, Renz EM, Holcomb JB. Burns sustained in Combat Explosions in Operations Iraqi and Enduring Freedom (OIF/OEF Explosions Burns). Burns. 2006 Nov;32(7):853-7. PMID: 16899341. 107. Kheirabadi BS, Sieber J, Holcomb JB. Assessment of the thrombogenic effect of fibrin sealant dressing in a vascular surgery model in rabbits. J Invest Surg. 2006 Nov-Dec;19(6):387-96. PMID: 17101608. 108. Eastridge BJ, Jenkins D, Flaherty S, Schiller H, Holcomb JB. Trauma System Development in a Theater of War: Experiences From Operation Iraqi Freedom and Operation Enduring Freedom. J Trauma. 2006 Dec;61(6):1366-72, discussion 1372-3. PMID: 17159678. 109. Todd SR, McNally MM, Holcomb JB, Kozar RA, Kao LS, Gonzalez EA, Cocanour CS, Vercruysse GA, Lygas MH, Brasseaux BK, Moore FA. A multidisciplinary clinical pathway decreases rib fractureassociated infectious morbidity and mortality in high-risk trauma patients. Am J Surg. 2006 Dec;192(6):806-11. PMID: 17161098. 110. Walters TJ, Holcomb JB, Cancio LC, Beekley AC, Baer DG. Emergency Tourniquets. J Am Coll Surg. 2007 Jan: 204(1):185-6. PMID: 17189131. 20

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111. Kheirabadi BS, Acheson EM, Deguzman R, Crissey JM, Delgado AV, Estep SJ, Holcomb JB. The Potential Utility of Fibrin Sealant Dressing in Repair of Vascular Injury in Swine. J Trauma. 2007 Jan;62(1):94-103. PMID: 17215739. 112. Gonzalez EA, Moore FA, Holcomb JB, Miller CC, Kozar RA, Todd SR, Cocanour CS, Balldin BC, McKinley BA. Fresh Frozen Plasma Should Be Given Earlier to Patients Requiring Massive Transfusion. J Trauma. 2007 Jan;62(1):112-9. PMID: 17215741. 113. Dewey WS, Hedman TL, Chapman TT. Wolf SE, Holcomb JB. The Reliability and Concurrent Validity of the Figure-of-Eight Methods of Measuring Hand Edema in Patients with Burns. J Burn Care Res. 2007 Jan-Feb;28(1):157-62. PMID: 17211219. 114. Hedman TL, Chapman TT, Dewey WS, Quick CD, Wolf Se, Holcomb JB. Two simple leg net devices designed to protect lower-extremity skin grafts and donor sites and prevent decubitus ulcer. J Burn Care Res. 2007 Jan-Feb;28(1):115-9. PMID: 17211210. 115. Blackbourne LH, Perkins J, McMullin N, Eastridge B, Holcomb JB. The Blood Augmentation Team. US Army Med Dep J. 2007 Jan-Mar: 7-10. PMID: 20084700. 116. Blackbourne LH, Grathwohl K, Eastridge B, MacDonald DL, Holcomb JB. Optimising transport of postoperative damage control patients in the combat zone. US Army Med Dep J. 2007 Jan-Mar: 11-6. PMID: 20084701. 117. Holcomb JB, Jenkins D, Rhee P, Johannigman J, Mahoney P, Mehta S, Cox ED, Gehrke MJ, Beilman GJ, Schreiber M, Flaherty SF, Grathwohl KW, Spinella PC, Perkins JG, Beekley AC, McMullin NR, Par MS, Gonzalez EA, Wade CE, Dubick MA, Schwab CW, Moore FA, Champion HR, Hoyt DB, Hess JR. Damage Control Resuscitation: Directly Addressing the Early Coagulopathy of Trauma. J Trauma. 2007 Feb;62(2):307-10. PMID: 17297317. 118. Perkins RM, Aboudara MC, Abbott KC, Holcomb JB. Resuscitative Hyperkalemia in Noncrush Trauma: A Prospective, Observational Study. Clin J AM Soc Neprhol. 2007 Mar;2(2):313-9. PMID: 17699430. 119. Convertino, VA, Cooke WH, Holcomb JB. Letters to the Editor. J Trauma. 2007 Apr;62(4):1070. 120. Convertino VA, Ryan KL, Richards CA, Cooke WH, Idris Ah, Metzger A, Holcomb JB, Adams BD, Lurie KG. Inspiratory Resistance Maintains Arterial Pressure during Central Hypovolemia: Implications for Treatment of Patients with Severe Hemorrhage. Crit Care Med. 2007 Apr;35(4):1145-22. PMID: 17334239. 121. Perkins JG, Schreiber MA, Wade CE, Holcomb JB. Early Versus Late Recombinant Factor VIIa in Combat Trauma Patients Requiring Massive Transfusion. J Trauma. 2007 May;62(5):1095-101. PMID: 17495707.

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122. Eastridge B, Salinas J, Baskin T. McManus J, Wade C, Holcomb JB. Trend in Shock Index after Injury Predicts Complications, Life Saving Interventions, and Mortality. Acad Emerg Med. 2007 May;14(5 Suppl 1):S138. 123. Tieu BH, Holcomb JB, Schreiber MA. Coagulopathy: its Pathophysiology and Treatment in the Injured Patient. World J Surg. 2007 May;31(5):1055-65. PMID: 17426904. 124. Martini WZ, Dubick MA, Wade CE, Holcomb JB. Evaluation of Tris-hydroxymethylaminomethane on Reversing Coagulation Abnormalities caused by Acidosis in Pigs. Crit Care Med. 2007 Jun;35(6):156874. PMID: 17452929. 125. Holcomb JB. Damage Control Resuscitation. J Trauma. 2007 Jun:62(6 Suppl):S36-7. PMID: 17556961. 126. McManus JG, Eastridge BJ, Wade CE, Holcomb JB. Hemorrhage Control Research on Today’s Battlefield: Lessons Applied. J Trauma. 2007 Jun;62(6 Suppl):S14. PMID: 17556941. 127. McManus JG, Eastridge BJ, DeWitte M, Greydanus DJ, Rice J, Holcomb JB. Combat Trauma Training for Current Casualty Care. J Trauma. 2007 Jun;62(6 Suppl):S13. PMID: 17556940. 128. Holcomb JB, McMullin NR, Pearse L, Caruso J, Wade CE, Oetjen-Gerdes L, Champion HR, Lawnick M, Farr W, Rodriguez S, Butler FK. Causes of Death in U.S. Special Operation Forces in the Global War on Terrorism: 2001-2004. Ann Surg. 2007 Jun;245(6):986-991. PMID: 17522526, PMCID: PMC1876965. 129. Horvath EE, Murray CK, Vaughan GM, Chung KK, Hospenthal DR, Wade CE, Holcomb JB, Wolf SE, Mason AD Jr, Cancio LC. Fungal Wound Infection (Not Colonization) Is Independently Associated with Mortality in Burn Patients. Ann Surg. 2007 Jun;245(6):978-85. PMID: 17522525, PMCID: PMC1876957. 130. Kheirabadi BS, Crissey JM, Deguzman R, Holcomb JB. In Vivo Bleeding Time and In Vitro Thrombelastography Measurements are Better Indicators of Dilutional Hypothermic Coagulopathy Than Prothrombin Time. J Trauma. 2007 Jun;62(6)1252-1361. PMID: 17563647. 131. Eastridge BJ, Salinas J, McManus JG, Blackbourne L, Bugler EM, Cooke WH, Convertino VA, Wade CE, Holcomb JB. Hypotension begins at 110 mm Hg: Redefining “Hypotension” with Data. J Trauma. 2007 Aug;63(2):291-7; discussion 297-9. PMID: 17693826. 132. Chung KK, Grathwohl KW, Poropatich RK, Wolf SE, Holcomb JB. Robotic telepresence: past, present and future. J Cardiothorac Vasc Anesth. 2007 Aug;21(4):593-6. PMID: 17678796. 133. Batchinsky AI, Cancio LC, Salinas J, Kuusela T, Cooke WH, Wang JJ, Boehme M, Convertino VA, Holcomb JB. Prehospital Loss of R-to-R Interval Complexity is Associated with Mortality in Trauma Patients. J Trauma. 2007 Sep;63(3):512-8. PMID: 18073594. 134. Schreiber MA, Perkins J, Kiraly L, Underwood S, Wade C, Holcomb JB. Early Predictors of Massive Transfusion in Combat Casualties. J Am Coll Surg. 2007 Oct;205(4):541-545. PMID: 17903727. 22

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135. Sondeen JL, Dubick MA, Holcomb JB, Wade CE. Uncontrolled Hemorrhage Differs from Volume or Pressure Matched Controlled Hemorrhage in Swine. Shock. 2007 Oct;28(4):426-33. PMID: 17558347. 136. Borgman MA, Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, Sebesta J, Jenkins D, Wade CE, Holcomb JB. The Ratio of Blood Products Transfused Affects Mortality in Patients Receiving Massive Transfusions at a Combat Support Hospital. J Trauma. 2007 Oct;63(4):305-13. PMID: 18090009. 137. Martini WZ, Holcomb JB. Acidosis and Coagulopathy: The Differential Effects on Fibrinogen Synthesis and Breakdown in Pigs. Ann Surg. 2007 Nov;246(5):831-5. PMID: 17968176. 138. Mann EA, Pidcoke HF, Salinas J, Wade CE, Holcomb JB, Wolf SE, Lacara T, Domagtoy C, Lickliter D, Quattrocchi K, Snipes L, Kuszai J, Prasnikar M. Accuracy of Gulcometers Should Not Be Assumed. Am J Crit Care. 2007 Nov;16(6):531-2. PMID: 17962493. 139. Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, Sebesta J, Jenkins D, Azarow K, Holcomb JB; 31st Combat Support Hospital Research Working Group. Risks Associated with Fresh Whole Blood and Red Blood Cell Transfusions in a Combat Support Hospital. Crit Care Med. 2007 Nov:35(11):2576-81. PMID: 17828033. 140. Butler FK Jr, Holcomb JB, Giebner SD, McSwain NE, Bagian J. Tactical Combat Casualty Care 2007: Evolving Concepts and Battlefield Experience. Milit Med. 2007 Nov;172(11 Supp):1-19. PMID: 18154234. 141. Stout LR, Jezior JR, Melton LP, Walker JA, Brengman ML, Neumeier ST, Smith RL, Vanfosson CA, Knuth TE, Holcomb JB, Cancio LC. Wartime Burn Care in Iraq: 28th Combat Support Hospital, 2003. Milit Med. 2007 Nov;172(11):1148-53. PMID: 18062387. 142. Kheirabadi Bs, Delgado AV, Dubick MA, Scherer MR, Fedyk CG, Holcomb JB, Pusateri AE. In Vitro Effect of Activated Recombinant Factor VII (rFVIIa) on Coagulation Properties of Human Blood at Hypothermic Temperatures. J Trauma. 2007 Nov;63(5):1079-86. PMID: 17993954. 143. Dewey WS, Richard RL, Hedman TL, Chapman TT, Quick DC, Holcomb JB, Wolf SE. A Review of Compression Glove Modifications to Enhance Functional grip: A Case Series. J Burn Care Res. 2007 Nov-Dec;28(6):888-91. PMID: 17992112. 144. Moore EE, Knudson MM, Schwab CW, Turnkey DD, Johannigman JA, Holcomb JB. Military-Civilian Collaboration in Trauma Care and the Senior Visiting Surgeon Program. N Engl J Med. 2007 Dec 27;357(26):2723-7. PMID: 18160694. 145. Pidcoke HF, Salinas J, Wanek SM, Concannon M, Loo F, Wirfel KL, Holcomb JB, Wolf SE, Wade CE. Patterns of Exogenous Insulin Requirement Reflect Insulin Sensitivity Changes in Trauma. Am J Surg. 2007 Dec;194(6):798-803; discussion 803. PMID: 18005774.

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146. Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, Sebesta J, Jenkins D, Azarow K, Holcomb JB. Members of the 31st CSH Research Working Group. Fresh Whole Blood Transfusions in Coalition Military, Foreign National, and Enemy Combatant Patients during Operation Iraqi Freedom at a U.S. Combat Support Hospital. World J Surg. 2008 Jan;32(1):2-6. PMID: 17990028. 147. Stansbury LG, Lalliss SJ, Branstetter JG, Bagg MR, Holcomb JB. Amputations in U.S. Military Personnel in the Current Conflicts in Afghanistan and Iraq. J Orthop Trauma. 2008 Jan;2291:43-6. PMID: 21477528. 148. Delgado AV, Kheirabadi BS, Fruchterman TM, Scherer M, Cortez D, Wade CE, Dubick MA, Holcomb JB. A Novel Biologic Hemostatic Dressing (fibrin patch) Reduces Blood Loss and Resuscitation Volume and Improves Survival in Hypothermic, Coagulopathic Swine with Grave V Liver Injury. J Trauma. 2008 Jan;64(1):75-80. PMID: 18188102. 149. Mann EA, Salinas J, Pidcoke HF, Wolf SE, Holcomb JB, Wade CE. Error Rates Resulting from Anemia Can Be Corrected in Multiple Commonly Used Point-of-Care Glucometers. J Trauma. 2008 Jan;64(1):1520; discussion 20-1. PMID: 18188093. 150. Blackbourne LH, Cole J, Mabry R, Morgan A, Barras P, Eastridge B, Holcomb JB. The “silent killer”: hyperventilation in the brain injured. US Army Med Dep J. 2008 Jan-Mar:50-5. PMID: 20091973. 151. Blackbourne LH, Mabry R, Sebesta J, Holcomb JB. Joseph Lister, noncompressible arterial hemorrhage, and the next generation of “tourniquets?” US Army Med Dep J. 2008 Jan-Mar:56-9. PMID: 20091974. 152. Batchinsky AI, Wolf SE, Molter N. Kuusela T, Jones JA, Moraru C, Boehme M, Williams K, Bielke P, Wade C, Holcomb JB, Cancio LC. Assessment of Cardiovascular Regulation after Burns by Nonlinear Analysis of the Electrocardiogram. J Burn Care Res. 2008 Jan-Feb;29(1):56-63. PMID: 18182898. 153. Hedman TL, Renz EM, Richard RL, Quick CD, Dewey WS, Barillo DJ, Cancio LC, Baer DG, Wolf SE, Holcomb JB. Incidence and Severity of Combat Hand Burns After All Army Activity Message. J Trauma. 2008 Feb;64:S169-173. PMID: 18376161. 154. Spinella PC, Perkins JG, McLaughlin DF, Niles SE, Grathwohl KW, Beekley AC, Salinas J, Mehta S, Wade CE, Holcomb JB. The effect of recombinant activated factor VII on mortality in combat-related casualties with severe trauma and massive transfusion. J Trauma 2008 Feb;64(2):286-93. PMID: 18301188. 155. Ritenour AE, Wickley A, Ritenour JS, Kriete BR, Blackbourne LH, Holcomb JB, Wade CE. Tympanic Membrane Perforation and Hearing Loss From Blast Overpressure in Operation Enduring Freedom and Operation Iraqi Freedom Wounded. J Trauma. 2008 Feb;64:S174-178. PMID: 18376162. 156. Chung KK, Juncos LA, Wolf SE, Mann EE, Renz EM, White CE, Barillo DJ, Clark RA, Jones JA, Edgecombe HP, Park MS, Albrecht MC, Cancio LC, Wade CE, Holcomb JB. Continuous Renal Replacement Therapy Improves Survival In Severely Burned Military Casualties With Acute Kidney Injury. J Trauma. 2008 Feb;64:S179-S187. PMID: 18376163. 24

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157. Park MS, Salinas J, Wade CE, Wang J, Martini WZ, Pusateri AE, Merrill GA, Chung KK, Wolf SE, Holcomb JB. Combining Early Coagulation and Inflammatory Status Improves Prediction of Mortality in Burned and Nonburned Trauma Patients. J Trauma. 2008 Feb;64:S188-S194. PMID: 18376164. 158. Gaylord KM, Cooper DB, Mercado JM, Kennedy, JE, Yoder LH, Holcomb JB. Incidence of Posttraumatic Stress Disorder and Mild traumatic Brain Injury in Burned Service Members: Preliminary Report. J Trauma. 2008 Feb;64:S200-S206. PMID: 18376167. 159. Trunkey DD, Johannigman JA, Holcomb JB. Lessons Relearned. Arch Surg. 2008 Feb;143(2):112-4. PMID: 18283134. 160. Plotkin AJ, Wade CE, Jenkins DH, Smith KA, Noe JC, Park MS, Perkins JG, Holcomb JB. A Reduction in Clot Formation Rate and Strength Assessed by Thrombelastography is Indicative of transfusion Requirements in Patients With Penetrating Injuries. J Trauma. 2008 Feb;64:S64-S68. PMID: 18376174. 161. Spinella PC, Perkins JG, Grathwohl KW, Beekley AC, Niles SE, McLaughlin DF, Wade CE, Holcomb JB. Effect of Plasma and Red Blood Cell Transfusions on Survival in Patients With Combat Related Traumatic Injuries. J Trauma. 2008 Feb;64:S69-S78. PMID: 18376175. 162. Stinger HK, spinella PC, Perkins JG, Grathwohl KW, Salina J, Martini WZ, Hess JR, Dubick MA, Simon CD, Beekley AC, Wolf, SE, Wade CE, Holcomb JB. The Ratio of Fibrinogen to Red Cells Transfused Affects Survival in Casualties Receiving Massive Transfusions at an Army Combat Support Hospital. J Trauma. 2008 Feb;64:S79-S85. PMID: 18376176. 163. Fox CJ, Gillespie DL, Cox ED, Mehta SG, Kragh JF, Salinas J, Holcomb JB. The Effectiveness of a Damage Control Resuscitation Strategy for Vascular Injury in a Combat Support Hospital: Results of a Case Control Study. J Trauma. 2008 Feb;64:S99-S107. PMID: 18376180. 164. Beekley AC, Blackbourne LH, Sebesta JA, McMullin N, Mullenix, PS, Holcomb JB, Members of the 31st Combat Support Hospital Research Group. Selective Nonoperative management of Penetrating Torso Injury From Combat Fragmentation Wounds. J Trauma. 2008 Feb;64:S108-S117. PMID: 18376152. 165. Schreiber, MA, Zink K, Underwood S, Sullenberger L, Kelly M, Holcomb JB. A Comparison Between Patients Treated at a Combat Support Hospital in Iraq and a Level I Trauma Center in the United States. J Trauma. 2008 Feb;64:S118-S122. PMID: 18376153. 166. Renz EM, Cancio LC, Barillo DJ, White CE, Albrecht MC, Thompson CK, Ennis JL, Wanek SM, King JA, Chung KK, Wolf SE, Holcomb JB. Long Range Transport of War-Related Burn Casualties. J Trauma. 2008 Feb;64:S136-S145. PMID: 18376156. 167. Ennis JL, Chung KK, Renz EM, Barillo DJ, Albrecht MC, Jones JA, Blackbourne LH, Cancio LC, Eastridge BJ, Flaherty SF, Dorlac WC, Kelleher KS, Wade CE, Wolf SE, Jenkins DH, Holcomb JB. Joint Theater Trauma System Implementation of Burn Resuscitation Guidelines Improves Outcomes in Severely Burned Military Casualties. J Trauma. 2008 Feb;64:S146-S152. PMID: 18376158.

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168. Ritenour AE, Dorlac WC, Fang R, Woods T, Jenkins DH, Flaherty SF, Wade CE, Holcomb JB. Complications After Fasciotomy Revision and Delayed Compartment Release in Combat Patients. J Trauma. 2008 Feb;64:S153-162. PMID: 18376159. 169. Owens BD, Kragh JF Jr, Wenke JC, Macaitis J, Wade CE, Holcomb JB. Combat wounds in operation Iraqi Freedom and operation Enduring Freedom. J Trauma. 2008 Feb;64(2):295-9. PMID: 18301189. 170. Holcomb JB. Clinical Outcomes from the War: Introduction. J Trauma. 2008 Feb;64:S1. PMID: 18376151. 171. Brosch LR, Holcomb JB, Thompson, JC, Cordts, PR. Establishing a Human Research Protection Program in a Combatant Command. J Trauma. 2008 Feb;64:S9-S13. PMID: 18376178. 172. Cordts PR, Brosch LR, Holcomb JB. Now and Then: Combat Casualty Care Policies for Operation Iraqi Freedom and Operating Enduring Freedom Compared With Those of Vietnam. J Trauma. 2008 Feb;64:S14-20. PMID: 18376157. 173. Kelly JF, Ritenour AE, McLaughlin DF, Bagg KA, Apodaca AN, Mallak CT, Pearse L, Lawnick MM, Champion HR, Wade CE, Holcomb JB. Injury Severity and Cause of Death From Operation Iraqi Freedom and Operation Enduring Freedom: 2003-2204 Versus 2006. J Trauma. 2008 Feb;64:S21-S27. PMID: 18376168. 174. Beekley AC, Sebesta JA, Blackbourne LH, Herbert FS, Kauvar DS, Baer DG, Walters, TJ, Mullenix PS, Holcomb JB. 31st Combat Support Hospital Research Group. Prehospital Tourniquet Use in Operation Iraqi Freedom: Effect on Hemorrhage Control and Outcomes. J Trauma. 2008 Feb;64:S28-37. PMID: 18376169. 175. Kragh JF, Walters TJ, Baer DG, Fox CJ, Wade CE, Salinas J, Holcomb JB. Practical Use of Emergency tourniquets to Stop Bleeding in Major Limb Trauma. J Trauma. 2008 Feb;64:S38-S50. PMID: 18376170. 176. Cancio LC, Wade CE, West SA, Holcomb JB. Prediction of Mortality and of the Need for Massive Transfusion in Casualties Arriving at Combat Support Hospitals In Iraq. J Trauma. 2008 Feb;64:S51-S56. PMID: 18376173. 177. McLaughlin DF, Niles SE, Salinas J, Perkins JG, Cox ED, Wade CE, Holcomb JB. A Predictive model for Massive Transfusion in Combat Casualty Patients. J Trauma. 2008 Feb;64:S57-S63. PMID: 18376173. 178. Hospenthal DR, Murray CK, Andersen RC, et.al. Guidelines for the Prevention of Infection After Combat-Related Injuries. J Trauma. 2008 Mar;64:S211-S220. PMID: 18316965. 179. Richard R, Hedman TL, Quick CD, Renz EM, Cancio LC, Chung KK, Dewey WS, Barillo DJ, Holcomb JB. Burns. Burns. 2008 Mar;34(2):295-6. PMID: 17913368. 180. Barillo DJ, Renz E, Broger K, Maok B, Wright G, Holcomb JB. An Emergency Medical Bag Set for Long-range Aeromedical Transportation. Am J Disaster Med. 2008 Mar-Apr;3(2):79-86. PMID: 18522249. 26

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181. Convertino VA, Ryan KL, Rickards CA, Salinas J, McManus JG, Cooke WH, Holcomb JB. Physiological and Medical monitoring for En Route Care of Combat Casualties. J Trauma. 2008 Apr;64(4 Suppl):S342-53. PMID: 18385586. 182. Salinas J, Drew G, Gallagher J, Cancio LC, Wolf SE, Wade CE, Holcomb JB, Herndon DN, Kramer GC. Closed-loop and Decision-assist Resuscitation of Burn Patients. J Trauma. 2008 Apr;64(4 Suppl):S32132. PMID: 18385584. 183. Chapman TT, Richard RL, Hedman TL, Renz EM, Wolf SE, Holcomb JB. Combat Casualty Hand Burns: Evaluating Impairment and Disability during Recovery. J Hand Ther. 2008. Apr-Jun;21(2):150-9. PMID: 18436137. 184. Kheirabadi BS, Crissey JM, Deguzman R, Perez MR, Cox AB, Dubick MA, Holcomb JB. Effects of Synthetic Versus Natural Colloid Resuscitation on Inducing Dilutional Coagulopathy in Hemorrhage in Rabbits. J Trauma. 2008 May;64(5):1213-28; discussion 1228-9. PMID: 18469644. 185. Richard RL, Hedman TL, Quick CD, Barillo DJ, Cancio LC, Renz EM, Chapman TT, Dewey WS, Dougherty ME, Holcomb JB, et al. A clarion to recommit and reaffirm burn rehabilitation. J Burn Care Res. 2008 May-Jun;29(3):425-32. PMID: 18388581. 186. Niles SE, McLaughlin DF, Perkins JG, Wade CE, LI Y, Spinella PC, Holcomb JB. Increased Mortality Associated with the Early Coagulopathy of Trauma in Combat Casualties. J Trauma. 2008 Jun;64(6):1459-63; discussion 1463-5. PMID: 18545109. 187. Hess JR, Holcomb JB. Transfusion practice in military trauma. Transfus Med. 2008 Jun;18(3):143-50. PMID: 18598276. 188. Gilbert TW, Nieponice A, Spievack AR, Holcomb J, Gilbert S, Badylak SF. Repair of the thoracic wall with an extracellular matrix scaffold in a canine model. J Surg Res. 2008 Jun 1;147(1):61-7. PMID: 17950323. 189. McMullin NR, Hedner U, Ezban M, Lauritzen B, Prince MD, Holcomb JB, Sondeen JL. Recombinant Factor VIIA Reduces Rebleed Hemorrhage Volume in a Swine Aortotomy Model: A Randomized Double-Blinded Study. Shock. 2008 Jun;29(6):703-708. PMID: 18496136. 190. Chung KK, Blackbourne LH, Renz EM, Cancio LC, Wang J, Park MS, Horvath EE, Albrecht MC, White CE, Wanek SM, Barillo DJ, Wolf SE, Holcomb JB. Global Evacuation of Burn Patients Does Not Increase the Incidence of Venous Thromboembolic Complications. J Trauma. 2008 Jul;65(1):19-24. PMID: 18580524. 191. Fox CJ, Gillespie DL, Cox ED, Kragh FJ Jr., Mehta SG, Salinas J, Holcomb JB. Damage Control Resuscitation for Vascular Surgery in a Combat Support Hospital. J Trauma. 2008 Jul;65(1):1-9. PMID: 18580508.

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192. Griffith ME, Gonzalez RS, Holcomb JB, Hospenthal DR, Wortmann GW, Murray CK. Factors Associated with Recovery of Acinetobacter Baumannii in A Combat Support Hospital. Infec Control Hosp Edimemiol. 2008 Jul;29(7):664-6. PMID: 18547156. 193. Hess JR, Dutton RB, Holcomb JB, Scalea TM. Giving Plasma at a 1:1 Ratio with Red Cells in Resuscitation: Who Might Benefit? Transfusion. 2008 Aug;48(8):1763-5. PMID: 18482190. 194. Chapman TT, Richard RL, Hedman TL, Chisholm GB, Quick CD, Baer DG, Dewey WS, Jones JS, Renz EM Barillo DJ, Cancio LC, Chung KK, Holcomb JB, Wolf SE. Military Return to Duty and Civilian Return to Work Factors Following Burns With Focus on the Hand and Literature Review. J Burn Care Res. 2008 Aug;29(5):756-62. PMID: 18695607. 195. Mann E, Pidcoke HF, Salinas J, Holcomb JB, Wolf SE, Wade CE. The Impact of Intensive Insulin Protocols and Restrictive Blood Transfusion Strategies on Glucose Measurement in American Burn Association (ABA) Verified Burn Centers. J Burn Care Res. 2008 Aug;29(5):718-23. PMID: 18825791. 196. Holcomb JB, Wade CE, Michalek JE, et al. Increased Plasma and Platelet to Red Blood Cell Ratios Improves Outcome in 466 Massively Transfused Civilian Trauma Patients. Ann Surg. 2008 Sep;248(3):447-458. PMID: 18791365. 197. Martini WZ, Cortez DS, Dubick MA, Park MS, Holcomb JB. Thromboelastography is Better than PT, aPTT, and Activated Clotting Time in Detecting Clinically Relevant Clotting Abnormalities After Hypothermia, Hemorrhagic Shock and Resuscitation in Pigs. J Trauma. 2008 Sep;65(3):535-43. PMID: 18784565. 198. Eastridge BJ, Blackbourne L, Wade CE, Holcomb JB. Radiologic diagnosis of explosion casualties. Am J of Disaster Med. 2008 Sept-Oct;3(5):301-5. PMID: 19069034. 199. Mann EA, Pidcoke HF, Salinas J, Holcomb JB, Wolf SE, Wade CE. The impact of intensive insulin protocols and restrictive blood transfusion strategies on glucose measurement in American Burn Association (ABA) verified burn centers. J Burn Care Res. 2008 Sep-Oct;29(5):718-23. PMID: 18825791. 200. Cancio LC, Batchinsky AI, Salinas J, Kuusela T, Convertino VA, Wade CE, Holcomb JB. Heart-rate complexity for prediction of prehospital lifesaving interventions in trauma patients. J Trauma. 2008 Oct;65(4):813-9. PMID: 18849796. 201. Parr MJ, Bouillon B, Brohi K, Dutton RP, Hauser CJ, Hess JR, Holcomb JB, Kluger Y, Mackway-Jones K, Rizoli SB, Yukioka T, Hoyt DB. Traumatic coagulopathy: where are the good experimental models? J Trauma. 2008 Oct;65(4):766-71. PMID: 18849788. 202. Hoyt DB, Dutton RP, Hauser CJ, Hess JR, Holcomb JB, Kluger Y, Mackway-Jones K, Parr MJ, Rizoli SB, Yukioka T, Bouillon B. Management of coagulopathy in the patients with multiple injuries: results from an international survey of clinical practice. J Trauma. 2008 Oct;65(4):755-64. PMID: 18849787.

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203. Hess JR, Brohi K, Dutton RP, Hauser CJ, Holcomb JB, Kluger Y, Mackway-Jones K, Parr MJ, Rizoli SB, Yukioka T, Hoyt DB, Bouillon B. The coagulopathy of trauma: a review of mechanisms. J Trauma. 2008 Oct;65(4):748-54. PMID: 18849786. 204. Shuja F, Shults C, Duggan M, Tabarra M, Butt MU, Fischer TH, Schreiber MA, Tieu B, Holcomb JB, Sondeen JL, Demoya M, Velmahos GC, Alam HB. Development and testing of freeze-dried plasma for the treatment of trauma-associated coagulopathy. J Trauma. 2008 Nov; 65(5):975-85. PMID: 19001961. 205. Matos RI, Holcomb JB, Callahan C, Spinella PC. Increased mortality rates of young children with traumatic injuries at a US army combat support hospital in Baghdad, Iraq, 2004. Pediatrics. 2008 Nov;122(5):e959-66. PMID: 18977963. 206. Murray CK, Loo FL, Hospenthal DR, Cancio LC, Jones JA, Kim SH, Holcomb JB, Wade CE, Wolf SE. Re: Incidence of systemic fungal infection and related mortality following severe burns. Burns. 2008 Dec; 34(8): 1108-12. PMID: 18691821. 207. Cho SD, Holcomb JB, Tieu BH, Englehart MS, Morris MS, Karahan ZA, Underwood SA, Muller PJ, Prince MD, Medina L, Sondeen J, Shults C, Duggan M, Tabbara M, Alam HB, Schreiber MA. Reproducibility of an Animal Model Simulating Complex Combat-Related Injury in a Multiple-Institution Format. Shock. 2009 Jan;31(1):87-96. PMID: 18497710. 208. Kragh JF Jr, Walters TJ, Baer DG, Fox CJ, Wade CE, Salinas J, Holcomb JB. Survival with emergency tourniquet use to stop bleeding in major limb trauma. Ann Surg. 2009 Jan;249(1):1-7. PMID: 19717268. 209. Spinella PC, Carroll CL, Staff I, Gross R, McQuay J, Keibel L, Wade CE, Holcomb JB. Duration of red blood cell storage is associated with increased incidence of deep vein thrombosis and in hospital mortality in patients with traumatic injuries. Crit Care. 2009;13(5):R151. PMID: 19772604, PMCID: PMC2784373. 210. Duchesne JC, Holcomb JB. Damage control resuscitation: addressing trauma-induced coagulopathy. Br J Hosp Med (Lond). 2009 Jan; 70(1): 22-5. PMID: 19357573. 211. Moore EE, Moore FA, Fabian TC, Bernard AC, Fulda GJ, Hoyt DB, Duane TM, Weireter LJ Jr, Gomez GA, Cipolle MD, Rodman GH Jr, Malangoni MA, Hides GA, Omert LA, Gould SA; PolyHeme Study Group. Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: the USA multicenter trial. J Am Coll Surg. 2009 Jan;208(1):1-13. PMID: 19228496. 212. Dewey WS, Richard RL, Hedman TL, Chapman TT, Quick CD, Renz EM, Blackbourne LH, Wolf SE, Holcomb JB. Opposition splint for partial thumb amputation: a case study measuring disability before and after splint use. J Hand Therapy. 2009 Jan-Mar;22(1):79-86. PMID: 18986797. 213. Holcomb JB, McManus JG, Kerr ST, Pusateri AE. Needle versus tube thoracostomy in a swine model of traumatic tension hemopneumothorax. Prehosp Emerg Care. 2009 Jan-Mar;13(1):18-27. PMID: 19145520.

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214. Gerhardt RT, De Lorenzo RA, Oliver J, Holcomb JB, Pfaff JA. Out-of-hospital combat casualty care in the current war in Iraq. Ann Emerg Med. 2009 Feb;53(2):169-74. PMID: 18472183. 215. Kheirabadi BS, Edens JW, Terrazas IB, Estep JS, Klemcke HG, Dubick MA, Holcomb JB. Comparison of new hemostatic granules/powders with currently deployed hemostatic products in a lethal model of extremity arterial hemorrhage in swine. J Trauma. 2009 Feb;66(2):316-26. PMID: 19204503. 216. Gomez R, Murray CK, Hospenthal DR, Cancio LC, Renz EM, Holcomb JB, Wade CE, Wolf SE. Causes of mortality by autopsy findings of combat casualties and civilian patients admitted to a burn unit. J Am Coll Surg. 2009 Mar;208(3):348-354. PMID: 19317995. 217. Nylund CM, Borgman MA, Holcomb JB, Jenkins D, Spinella PC. Thromboelastography to direct the administration of recombinant activated factor VII in a child with traumatic injury requiring massive transfusion. Pediatr Crit Care Med. 2009 Mar;10(2):e22-6. PMID: 19265363. 218. Thomas R, McManus JG, Johnson A, Mayer P, Wade C, Holcomb JB. Ocular injury reduction from ocular protection use in current combat operations. J Trauma. 2009 Apr; 66 (4 Suppl): S99-103. PMID: 19359977. 219. White CE, Simmons JW, Holcomb JB, Aydelotte JD, Eastridge BJ, Blackbourne L. Impact of extremity amputation on combat wounded undergoing exploratory laparotomy. J Trauma. 2009 Apr; 66 (4 Suppl): S86-92. PMID: 19359975. 220. Perkins JG, Andrew CP, Spinella PC, Blackbourne LH, Grathwohl KW, Repine TB, Ketchum L, Waterman P, Lee RE, Beekley AC, Sebesta JA, Shorr AF, Wade CE, Holcomb JB. An evaluation of the impact of apheresis platelets used in the setting of massively transfused trauma patients. J Trauma. 2009 Apr; 66 (4 Suppl): S77-84; discussion S84-5. PMID: 19359974. 221. Spinella PC, Perkins JG, Grathwohl KW, Beekley AC, Holcomb JB. Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries. J Trauma. 2009 Apr; 66 (4 Suppl): S69-76. PMID: 19359974, PMCID: PMC3126655. 222. Martin M, Oh J, Currier H, Tai N, Beekley A, Holcomb J. An analysis of in-hospital deaths at a modern combat support hospital. J Trauma. 2009 Apr;66(4 Suppl):S51-60. PMID: 19359971. 223. Eastridge BJ, Stansbury LG, Stinger H, Blackbourne L, Holcomb JB. Forward Surgical Teams provide comparable outcomes to combat support hospitals during support and stabilization operations on the battlefield. J Trauma. 2009 Apr; 66 (4 Suppl): S48-50. PMID: 19359970. 224. Nessen SC, Cronk DR, Edens J, Eastridge BJ, Little TR, Windsor J, Blackbourne LH, Holcomb JB. US Army two-surgeon teams operating in remote Afghanistan—an evaluation of split based Forward Surgical Team operation. J Trauma. 2009 Apr; 66 (4 Suppl): S37-47. PMID: 19359969.

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225. Gaylord KM, Holcomb JB, Zolezzi ME. A comparison of posttraumatic stress disorder between combat casualties and civilians treated at a military burn center. J Trauma. 2009 Apr; 66 (4 Suppl): S191-5. PMID: 19359965. 226. Mora AG, Ritenour AE, Wade CE, Holcomb JB, Blackbourne LH, Gaylord KM. Posttraumatic stress disorder in combat casualties with burns sustaining primary blast and concussive injuries. J Trauma. 2009 Apr; 66 (4 Suppl): S178-85. PMID: 19359963. 227. Murray CK, Wilkins K, Molter NC, Yun HC, Dubick MA, Spott MA, Jenkins D, Eastridge B, Holcomb JB, Blackbourne LH, Hospenthal DR. Infections in combat casualties during Operations Iraqi and Enduring Freedom. J Trauma. 2009 Apr; 66 (4 Suppl): S138-44. PMID: 19359957. 228. Beekley AC, Martin MJ, Spinella PC, Telian SP, Holcomb JB. Predicting resource needs for multiple and mass casualty events in combat: lessons learned from combat support hospital experience in Operation Iraqi Freedom. J Trauma. 2009 Apr; 66 (4 Suppl): S129-37. PMID: 19359956. 229. Fox CJ, Mehta SG, Cox ED, Kragh JF Jr., Salinas J, Holcomb JB. Effect of recombinant factor VIIa as an adjunctive therapy in damage control for wartime vascular injuries: a case control study. J Trauma. 2009 Apr; 66 (4 Suppl): S112-9. PMID: 19359954. 230. Mann EA, Pidcoke HF, Salinas J, Wolf SE, Wade CE, Holcomb JB. Hematocrit causes the most significant error in point of care glucometers. Crit Care Med. 2009 Apr;37(4):1530; author reply 1530-1. PMID: 19318857. 231. Maani CV, Desocio PA, Holcomb JB. Coagulopathy in trauma patients: what are the main influence factors? Curr Opin Anaesthesiol. 2009 Apr;22(2):255-260. PMID: 19300245. 232. Wade CE, Dubick MA, Blackbourne LH, Holcomb JB. It is time to assess the utility of thrombelastography in the administration of blood products to the patient with traumatic injuries. J Trauma. 2009 Apr; 66 (4):1258. PMID: 19359946. 233. Dau BK, Gilardi KV, Gulland FM, Higgins A, Holcomb JB, Leger JS, Ziccardi MH. Fishing gear-related injury in California marine wildlife. J Wildl Dis. 2009 Apr; 45(2):355-62. PMID: 19395745. 234. Zink KA, Sambasivan CN, Holcomb JB, Chisholm G, Schreiber MA. A high ratio of plasma and platelets to packed red blood cells in the first 6 hours of massive transfusion improves outcomes in a large multicenter study. Am J Surg. 2009 May; 197(5): 565-70; discussion 570. PMID: 19393349. 235. Markell KW, Renz EM, White CE, Albrecht ME, Blackbourne LH, Park MS, Barillo DA, Chung KK, Kozar RA, Minei JP, Cohn SM, Herndon DN, Cancio LC, Holcomb JB, Wolf SE. Abdominal complications after severe burns. J Am Coll Surg. 2009 May; 208(5): 940-7; discussion 947-9. PMID: 19476867.

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236. Champion HR, Holcomb JB, Young LA. Injuries from explosions: physics, biophysics, pathology and required research focus. J Trauma. 2009 May; 66 (5): 1468-77; discussion 1477. Review. PMID: 19430256. 237. Aboushwareb T, Eberli D, Ward C, Broda C, Holcomb J, Atala A, Van Dyke M. A keratin biomaterial gel hemostat derived from human hair: evaluation in a rabbit model of lethal liver injury. J Biomed Mater Res B Appl Biomater. 2009 Jul;90(1):45-54. PMID: 18988274. 238. Park MS, Martini WZ, Dubick MA, Salinas J, Butenas S, Kheirabadi BS, Pusateri AE, Guymon CH, Wolf SE, Mann KG, Holcomb JB. Thromboelastography as a better indicator of hypercoagulable state after injury than prothrombin time or activated partial thromboplastin time. J Trauma. 2009 Aug; 67 (2):26675; discussion 275-6. PMID: 19667878. 239. Edens JW, Beekley AC, Chung KK, Cox ED, Eastridge BJ, Holcomb JB, Blackbourne LH. Longterm outcomes after combat casualty emergency department thoracotomy. J Am Coll Surg. 2009 Aug; 2009(2): 188-97. PMID: 19632595. 240. Spoerke N, Zink K, Cho SD, Differding J, Muller P, Karahan A, Sondeen J, Holcomb JB, Schreiber M. Lyophilized plasma for resuscitation in a swine model of severe injury. Arch Surg. 2009 Sep; 144(9):82934. PMID: 19797107. 241. Kheirabadi BS, Scherer MR, Estep JS, Dubick MA, Holcomb JB. Determination of efficacy of new hemostatic dressings in a model of extremity arterial hemorrhage in swine. J Trauma. 2009 Sep; 67(3):450-9; discussion 459-60. PMID: 19741385. 242. White CE, Hsu JR, Holcomb JB. Haemodynamically unstable pelvic fractures. Injury. 2009 Oct; 40 (10): 1023-30. PMID: 19371871. 243. Alam HB, Bice LM, Butt MU, Cho SD, Dubick MA, Duggan M, Englehart MS, Holcomb JB, Morris MS, Prince MD, Schreiber MA, Shults C, Sondeen JL, Tabbara M, Tieu BH, Underwood SA; Hemostatic Resuscitation Research Group. Testing of blood products in a polytrauma model: results of a multiinstitutional randomized preclinical trial. J Trauma. 2009 Oct; 67(4):856-64. PMID: 19820596. 244. Dutton R, Hauser C, Boffard K, Dimsitts J, Bernard G, Holcomb J, Leppäniemi A, Tortella B, Bouillon B; CONTROL Steering Committee. Scientific and logistical challenges in designing the CONTROL trial: recombinant factor VIIa in severe trauma patients with refractory bleeding. Clin Trials. 2009 Oct; 6(5):467-79. PMID: 19737846. 245. Silverman TA, Weiskopf RB; Planning Committee and the Speakers. Hemoglobin-based oxygen carriers: current status and future directions. Anesthesiology. 2009 Nov; 111(5):946-63. PMID: 19858869. 246. Spinella PC, Holcomb JB. Resuscitation and transfusion principles for traumatic hemorrhagic shock. Blood Rev. 2009 Nov; 23(6):231-40. PMID: 19695750.

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247. Pidcoke HF, Wanek SM, Rohleder LS, Holcomb JB, Wolf SE, Wade CE. Glucose variability is associated with high mortality after severe burn. J Trauma. 2009 Nov; 67(5):990-5. PMID: 19901659. 248. Eastridge BJ, Costanzo G, Jenkins D, Spott MA, Wade C, Greydanus D, Flaherty S, Rappold J, Dunne J, Holcomb JB, Blackbourne LH. Impact of joint theater trauma system initiatives on battlefield injury outcomes. Am J Surg. 2009 Dec; 196(6):852-7. PMID: 19969141. 249. McLaughlin DF, Wade CE, Champion HR, Salinas J, Holcomb JB. Thromboembolic complications following trauma. Transfusion. 2009 Dec; 49 Suppl 5:256S-63S. PMID: 19954488. 250. Cox ED, Schreiber MA, McManus J, Wade CE, Holcomb JB. New hemostatic agents in the combat setting. Transfusion. 2009 Dec; 49 Suppl 5:248S-55S. PMID: 19954487. 251. Holcomb JB, Spinella PC. Optimal use of blood in trauma patients. Biologicals. 2010 Jan; 38(1):72-7. PMID: 20074980, PMCID: PMC3126656. 252. Bouillon B, Brohi K, Hess JR, Holcomb JB, Parr MJ, Hoyt DB. Education initiative on critical bleeding in trauma: Chicago, July 11-13, 2008. J Trauma. 2010 Jan; 68 (1):225-30. PMID: 20065778. 253. Levy JH, Dutton RP, Hemphill JC 3rd, Shander A, Cooper D, Paidas MG, Kessler CM, Holcomb JB, Lawson JH, Hemostasis Summit Participants. Multidisciplinary approach to the challenge of hemostasis. Anesth Analg. 2010 Feb; 110(2): 354-64. PMID: 20007735. 254. Pidocke HF, Wade CE, Mann EA, Salinas J, Cohee BM, Holcomb JB, Wolf SE. Anemia causes hypoglycemia in intensive care unit patients due to error in single-channel glucometers: methods of reducing patient risk. Crit Care Med. 2010 Feb;38(2):471-6. PMID: 19789438. 255. Newgard CD, Rudser K, Hedges JR, Kerby JD, Stiell IG, Davis DP, Morrison LJ, Bulger E, Terndrup T, Minei JP, Bardarson B, Emerson S, Holcomb, JB, and other ROC Investigators. A critical assessment of the out-of-hospital trauma triage guidelines for physiologic abnormality. J Trauma. 2010 Feb; 68(2):45262. PMID: 20154558. 256. Newgard CD, Schmicker RH, Hedges JR, Trickett JP, Davis DP, Bulger EM, Aufderheide TP, Minei JP, Hata JS, Gubler KD, Brown TB, Yelle JD, Bardarson B, Nichol G, Holcomb JB, and Resuscitation Outcomes Consortium Investigators. Emergency medical services intervals and survival in trauma: assessment of the "golden hour" in a North American prospective cohort. Ann Emerg Med. 2010 Mar; 55(3):235-246.e4. PMID: 19783323, PMCID: PMC3008652. 257. Yun HC, Blackbourne LH, Jones JA, Holcomb JB, Hospenthal DR, Wolf SE, Renz EM, Murray CK. Infectious complications of noncombat trauma patients provided care at a military trauma center. Mil Med. 2010 May; 175(5): 317-23. PMID: 20486502. 258. Ritenour AE, Christy RJ, Roe JL, Baer DG, Dubick MA, Wade CE, Holcomb JB, Walters TJ. The effect of a hypobaric, hypoxic environment on acute skeletal muscle edema after ischemia-reperfusion injury in rats. J Surg Res. 2010 May 15; 160(2):253-9. PMID: 19577258. 33

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259. Champion HR, Holcomb JB, Lawnick MM, Kelliher T, Spott MA, Galarneau MR, Jenkins DH, West SA, Dye J, Wade CE, Eastridge BJ, Blackbourne LH, Shair EK. Improved Characterization of combat injury. J Trauma. 2010 May; 68(5): 1139-50. PMID: 20453770. 260. Lundy JB, Swift CB, McFarland CC, Mahoney LC, Perkins RM, Holcomb JB. A Descriptive Analysis of Patients Admitted to the Intensive Care Unit of the 10th Combat Support Hospital Deployed in Ibn Sina, Baghdad, Iraq From October 19, 2005 to October 19, 2006. J Intensive Care Med. 2010 May-June; 25(3): 156-62. PMID: 20097667. 261. Nunez TC, Young PP, Holcomb JB, Cotton BA. Creation, implementation, and maturation of a massive transfusion protocol for the exsanguinating trauma patient. J Trauma. 2010 June; 68(6): 1498-505. PMID; 20539191, PMCID: PMC3136378. 262. Inaba K, Branco BC, Rhee P, Blackbourne LH, Holcomb JB, Teixeira PG, Shulman I, Nelson J, Demetriades D. Impact of plasma transfusion in trauma patients who do not require massive transfusion. J Am Coll Surg. 2010 Jun; 210(6): 957-65. PMID: 20510805. 263. Ritenour AE, Blackbourne LH, Kelly JF, McLaughlin DF, Pearse LA, Holcomb JB, Wade CE. Incidence of primary blast injury in US military overseas contingency operations: a retrospective study. Ann Surg. 2010 June; 251(6):1140-4. PMID: 20485126. 264. Holcomb JB. Optimal use of blood products in severely injured trauma patients. Hematology Am Soc Hematol Educ Program. 2010;2010:465-9. PMID: 21239837, PMCID: PMC3126660. 265. Deal VT, McDowell D, Benson P, Iddins B, Gluck G, Griffay A, Lutz R, Pennardt A, Kane S, Gilpatrick S, Bowling FY, Paisley JT, Williamson JR, Kiely R, Anderson P, Frasier BA, Moore R, Bakken H, Burlingame BS, Hammesfahr R, Hesse RW, Holcomb JB, Johnson TR, Morgan B, Talbot TS, Wedmore I. Tactical combat casualty care February 2010. Direct from the Battlefield: TCCC lessons learned in Iraq and Afghanistan. J Spec Oper Med. 2010 Summer;10(3):77-119. PMID: 21140983. 266. Edens JW, Chung KK, Pamplin JC, Allan PF, Jones JA, King BT, Cancio LC, Renz EM, Wolf SE, Wade CE, Holcomb JB, Blackbourne LH. Predictors of early acute lung injury at a combat support hospital: a prospective observational study. J Trauma 2010 Jul; 69 Suppl 1:S81-6. PMID: 20622625. 267. Van PY, Sambasivan CN, Wade CE, Jones JA, Holcomb JB, Schreiber MA, Blackbourne LH. High transfusion ratios are not associated with increased complication rates in patients with severe extremity injuries. J Trauma 2010 Jul; 69 Suppl 1:S64-8. PMID: 20622622. 268. Pati S, Matijevic N, Doursout MF, Ko T, Cao Y, Deng X, Kozar RA, Hartwell E, Conyers J, Holcomb JB. Protective effects of fresh frozen plasma on vascular endothelial permeability, coagulation, and resuscitation after hemorrhagic shock are time dependent and diminish between days 0 and 5 after thaw. J Trauma 2010 Jul; 69 Suppl 1:S55-63. PMID: 20622621, PMCID: PMC3126659. 269. Eastridge BJ, Wade CE, Spott MA, Costanzo G, Dunne J, Flaherty S, Holcomb JB, West S, Apodaca A, Blackbourne L, Cassells SW. Utilizing a trauma systems approach to benchmark and improve combat casualty care. J Trauma 2010 Jul; 69 Suppl 1:S5-9. PMID: 20622620. 34

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270. Larson CR, White CE, Spinella PC, Jones JA, Holcomb JB, Blackbourne LH, Wade CE. Association of shock, coagulopathy, and initial vital signs with massive transfusion in combat casualties. J Trauma 2010 Jul; 69 Suppl 1:S26-32. PMID: 20622616. 271. Allen PB, Salyer SW, Dubick MA, Holcomb JB, Blackbourne LH, Wade CE. Preventing hypothermia: comparison of current devices used by the US Army in an in vitro warmed fluid model. J Trauma 2010 Jul; 69 Suppl 1:S154-61. PMID: 20622611. 272. Beekley AC, Martin MJ, Nelson T, Grathwohl KW, Griffith M, Beilman G, Holcomb JB. Continuous noninvasive tissue oximetry in the early evaluation of the combat casualty: a prospective study. J Trauma 2010 July; 69 Suppl 1:S14-25. PMID: 20622608. 273. McMullin NR, Wade CE, Holcomb JB, Nielsen TG, Rossaint R, Riou B, Rizoli SB, Kluger Y, Choong PI, Warren B, Tortella BJ, Boffard KD; NovoSeven Trauma Study Group. Prolonged prothrombin time after recombinant activated factor VII therapy in critically bleeding trauma patients is associated with adverse outcomes. J Trauma. 2010 Jul; 69 (1): 60-9. PMID: 20622579. 274. Estrera AL, Gochnour DC, Azizzadeh A, Miller CC 3rd, Coogan S, Charlton-Ouw K, Holcomb JB, Safi HJ. Progress in treatment of blunt thoracic aortic injury: 12-year single-institution experience. Ann Thorac Surg. 2010 Jul; 90(1): 64-71. PMID: 20609750. 275. Holcomb JB. Traditional transfusion practices are changing. Crit Care. 2010; 14(3): 162. PMID: 20550726, PMCID: PMC2911712. 276. Wade CE, Eastridge BJ, Jones JA, West SA, Spinella PC, Perkins JG, Dubick MA, Blackbourne LH, Holcomb JB. Use of recombinant factor VIIa in US military casualities for a five-year period. J Trauma. 2010 Aug; 69(2):353-9. PMID: 20699744. 277. Christensen MC, Parr M, Tortella BJ, Malmgren J, Morris S, Rice T, Holcomb JB; CONTROL Study Group. Global differences in causes, management, and survival after severe trauma: the recombinant activated factor VII phase 3 trauma trial. J Trauma 2010 Aug; 69(2):344-52. PMID: 20699743. 278. Inaba K, Branco BC, Rhee P, Holcomb JB, Blackbourne LH, Shulman I, Nelson J, Demetriades D. Impact of ABO-identical vs ABO-compatible nonidentical plasma transfusion in trauma patients. Arch Surg 2010 Sept; 145(9): 899-906. PMID: 20855762. 279. D’Avignon LC, Hogan BK, Murray CK, Loo FL, Hospenthal DR, Cancio LC, Kim SH, Renz EM, Barillo D, Holcomb JB, Wade CE, Wolf SE. Contribution of bacterial and viral infections to attributable mortality in patients with severe burns: an autopsy series. Burns. 2010 Sep; 36(6):773-9. PMID: 20074860. 280. Nunez TC, Dutton WD, May AK, Holcomb JB, Young PP, Cotton BA. Emergency department blood transfusion predicts early massive transfusion and early blood component requirement. Transfusion. 2010 Sep; 50(9):1914-20. PMID: 20456707.

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281. Hauser CJ, Boffard K, Dutton R, Bernard GR, Croce MA, Holcomb JB, Leppaniemi A, Parr M, Vincent JL, Tortella BJ, Dimsits J, Bouillon B; CONTROL Study Group. Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma. 2010 Sep; 69(3):489-500. PMID: 20838118. 282. Bulger EM, May S, Brasel KJ, Schreiber M, Kerby JD, Tisherman SA, Newgard C, Slutsky A, Coimbra R, Emerson S, Minei JP, Bardarson B, Kudenchuk P, Baker A, Christenson J, Idris A, Davis D, Fabian TC, Aufderheide TP, Callaway C, Williams C, Banek J, Vaillancourt C, van Heest R, Sopko G, Hata JS, Hoyt DB; ROC Investigators. Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: a randomized controlled trial. JAMA 2010 Oct 6; 304(13): 1455-64. PMID: 20924011, PMCID: PMC3015143. 283. Chung KK, Wolf SE, Renz EM, Allan PF, Aden JK, Merrill GA, Shelhamer MC, King BT, White CE, Bell DG, Schwacha MG, Wanek SM, Wade CE, Holcomb JB, Blackbourne LH, Cancio LC. Highfrequency percussive ventilation and low tidal volume ventilation in burns: A randomized controlled trial. Crit Care Med. 2010 Oct; 38(10):1970-7. PMID: 20639746. 284. Letourneau PA, Pati S, Gerber MH, Jimenez F, Holcomb JB. Fresh Frozen Plasma Increases Adhesion Molecule Expression on Human Pulmonary Endothelial Cells. J Surg Res. 2010 Oct; 163(2):317-22. PMID: 20599210. 285. Spoerke NJ, Van PY, Differding JA, Zink KA, Cho SD, Muller PJ, Karahan ZA, Sondeen JL, Holcomb JB, Schreiber MA. Red Blood Cells Accelerate the Onset of Clot Formation in Polytrauma and Hemorrhagic Shock. J Trauma. 2010 Nov; 69(5):1054-9; discussion 1059-61. PMID: 21068611. 286. Inaba K, Lustenberger T, Rhee P, Holcomb JB, Blackbourne LH, Shulman I, Nelson J, Talving P, Demetriades D. The impact of platelet transfusion in massively transfused trauma patients. J Am Coll Surg 2010 Nov; 211(5):573-9. PMID: 20846882. 287. Eastridge BJ, Butler F, Wade CE, Holcomb JB, Salinas J, Champion HR, Blackbourne LH. Field Triage Score (FTS) in battlefield casualties: Validation of a novel triage technique in a combat environment. Am J Surg. 2010 Dec;200(6):724-7; discussion 727. PMID: 21146011. 288. Muellner SK, Haut ER, Streiff MB, Holcomb JB, Cotton BA. ABO blood groups as a potential risk factor for venous thromboembolism in acutely injured patients. Thromb Haemost. 2011 Jan 3; 105(1):5-13. PMID: 21103665. 289. Pati S, Khakoo AY, Zhao J, Jimenez F, Gerber MH, Harting M, Redell JB, Grill R, Matsuo Y, Guha S, Cox CS, Reitz MS, Holcomb JB, Dash PK. Human mesenchymal stem cells inhibit vascular permeability by modulating vascular endothelial cadherin/β-catenin Signaling. Stem Cells Dev. 2011 Jan; 20(1):89101. PMID: 20446815, PMCID: PMC3128758. 290. Knudson MM, Cohen MJ, Reidy R, Jaeger S, Bacchetti P, Jin C, Wade CE, Holcomb JB. Trauma, transfusions, and use of recombinant factor VIIa: A multicenter case registry report of 380 patients from the Western Trauma Association. J Am Coll Surg. 2011 Jan; 212(1):87-95. PMID: 21115374. 36

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291. Matijevic N, Kostousov V, Wang YW, Wade CE, Wang W, Letourneau P, Hartwell E, Kozar R, Ko T, Holcomb JB. Multiple levels of degradation diminish hemostatic potential of thawed plasma. J Trauma. 2011 Jan; 70(1):71-9; discussion 79-80. PMID: 21217484, PMCID: PMC3126652.

292. Holcomb JB, Weiskopf R, Champion H, Gould SA, Sauer RM, Brasel K, Bochicchio G, Bulger E, Cotton BA, Davis D, Dutton R, Hauser CJ, Hess JR, Hides GA, Knudson P, Mackenzie E, McGinnis RL, Michalek J, Moore FA, Omert L, Pollock BH, Tortella B, Sugarman J, Schreiber MA, Wade CE. Challenges to effective research in acute trauma resuscitation: consent and endpoints. Shock 2011 Feb; 35(2):107-13. PMID: 20926987. 293. Perkins JG, Cap AP, Spinella PC, Shorr AF, Beekley AC, Grathwohl KW, Rentas FJ, Wade CE, Holcomb JB, the 31st Combat Support Hospital Research Group. Comparison of platelet transfusion as fresh whole blood versus apheresis platelets for massively transfused combat trauma patients (CME). Transfusion. 2011 Feb; 51(2):242-252. PMID: 20796254. 294. Azizzadeh A, Valdes J, Miller CC 3rd, Nguyen LL, Estrera AL, Charlton-Ouw K, Coogan SM, Holcomb JB, Safi HJ. The Utility of Intravascular Ultrasound Compared to Angiography in the Diagnosis of Blunt Traumatic Aortic Injury. J Vasc Surg. 2011 Mar; 53(3):608-14. PMID: 21129901. 295. Kragh JF Jr, Wade CE, Baer DG, Jones JA, Walters TJ, Hsu JR, Wenke JC, Blackbourne LH, Holcomb JB. Fasciotomy rates in operations enduring freedom and iraqi freedom: association with injury severity and tourniquet use. J Orthop Trauma. 2011 Mar; 25(3):134-9. PMID: 21321506. 296. Holcomb JB. Tranexamic Acid in Elective Craniosynostosis Surgery: It Works, But How? Anesthesiology. 2011 Apr; 114(4): 737-8. PMID: 21358316. 297. McSwain NE, Champion HR, Fabian TC, Hoyt DB, Wade CE, Eastridge BJ, Rasmussen TE, Roussel RR, Butler FK, Holcomb JB, Schreiber MA, Shackford SR, Blackbourne LH. State of the art of fluid resuscitation 2010: prehospital and immediate transition to the hospital. J Trauma. 2011 May;70(5 Suppl):S2-S10. PMID: 21841563. 298. Bernard AC, Moore EE, Moore FA, Hides GA, Guthrie BJ, Omert LA, Gould SA, Rodman GH Jr; PolyHeme Study Group. J Trauma. 2011 May;70(5 Suppl):S34-7. PMID: 21841568. 299. Holcomb JB. Reconstitution: reverse engineering. J Trauma. 2011 May;70(5 Suppl):S65-7. PMID: 21841579. 300. Hatch QM, Osterhout LM, Ashraf A, Podbielski J, Kozar RA, Wade CE, Holcomb JB, Cotton BA. Current use of damage-control laparotomy, closure rates, and predictors of early fascial closure at the first take-back. J Trauma. 2011 Jun;70(6):1429-36. PMID: 21817981.

301. Wade CE, Salinas J, Eastridge BJ, McManus JG, Holcomb JB. Admission hypo- or hyperthermia and survival after trauma in civilian and military environments. Int J Emerg Med. 2011 Jun 23;4(1):35. PMID: 21699695, PMCID: PMC3134000. 37

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302. Kozar RA, Peng Z, Zhang R, Holcomb JB, Pati S, Park P, Ko TC, Paredes A. Plasma Restoration of Endothelial Glycocalyx in a Rodent Model of Hemorrhagic Shock. Anesth Analg. 2011 Jun;112(6): 128995. PMID: 21346161 303. Dutton RP, Parr M, Tortella BJ, Champion HR, Bernard GR, Boffard K, Bouillon B, Croce MA, Dimsits J, Holcomb JB, Leppaniemi A, Vinvent JL, Hauser CJ; for the CONTROL Study Group. Recombinant Activated Factor VII Safety in Trauma Patients: Results from the CONTROL Trial. J Trauma. 2011 Jul;71(1):12-19. PMID: 21610529. 304. Duan C, Cao Y, Deng X, Wang W, Yang W, Liu X, Chen Z, Pati S, Kozar RA, Gonzalez EA, Wade CE, Holcomb JB, Ko TC. Increased TGF-β Contributes to Deterioration of Refrigerated Fresh Frozen Plasma's Effects in Vitro on Endothelial Cells. Shock. 2011 Jul;36(1):54-9. PMID: 21330944. 305. Borgman MA, Spinella PC, Holcomb JB, Blackbourne LH, Wade CE, Lefering R, Bouillon B, Maegele M. The effect of FFP:RBC ratio on morbidity and mortality in trauma patients based on transfusion prediction score. Vox Sang. 2011 Jul;101(1):44-54. PMID: 21438884. 306. Matijevic N, Wang YW, Kostousov V, Wade CE, Vijayan KV, Holcomb JB. Decline in platelet microparticles contributes to reduced hemostatic potential of stored plasma. Thromb Res. 2011 Jul;128(1):35-41. PMID: 21421259 307. Simmons JW, White CE, Eastridge BJ, Holcomb JB, Perkins JG, Mace JE, Blackbourne LH. Impact of improved combat casualty care on combat wounded undergoing exploratory laparotomy and massive transfusion. J Trauma. 2011 Jul;71(1 Suppl): S82-6. PMID: 21795883. 308. Oh BC, Holcomb JB. Traumatic brain injury and resuscitation with blood products: what should we do? Crit Care. 2011 Jul 22;15(4):172. PMID: 21867569. 309. Holcomb JB, Wade CE, Trauma Outcomes Group. Defining present blood component transfusion practices in trauma patients: Papers from the Trauma Outcomes Group. J Trauma. 2011 Aug; 71(2):S315317. PMID: 21814098. 310. Wade CE, del Junco DJ, Holcomb JB, Trauma Outcomes Group. Variation between level 1 trauma centers in 24-hour mortality in severely injured patients requiring a massive transfusion. J Trauma. 2011 Aug; 71(2):S389-393. PMID: 21814110. 311. Sambasivan CN, Kunio NR, Nair PV, Zink KA, Michalek JE, Holcomb JB, Schreiber MA, Trauma Outcomes Group. High ratios of plasma and platelets to packed red blood cells do not affect mortality in nonmassively transfused patients. J Trauma. 2011 Aug; 71(2):S329-336. PMID: 21814100. 312. Holcomb JB, Zarzabal LA, Michalek JE, Kozar RA, Spinella PC, Perkins JG, Matijevic N, Dong JF, Pati S, Wade CE, Trauma Outcomes Group. Increased platelet:RBC ratios are associated with improved survival after massive transfusion. 2011 Aug; 71(2):S318-328. PMID: 21814099. 313. Barbosa RR, Rowell SE, Sambasivan CN, Diggs BA, Spinella PC, Schreiber MA, Trauma Outcomes Group. A predicitive model for mortality in massively transfused trauma patients. J Trauma. 2011 Aug; 71(2):S370-374. PMID: 21814106. 38

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314. Rowell SE, Barbosa RR, Diggs BS, Schreiber MA, Trauma Outcomes Group. Specific abbreviated injury scale values are responsible for the underestimation of mortality in penetrating trauma patients by the injury severity score. J Trauma. 2011 Aug; 71(2):S384-388. PMID: 21814109. 315. Barbosa RR, Rowell SE, Diggs BS, Schreiber MA, Trauma Outcomes Group. Profoundly abnormal initial physiologic and biochemical data cannot be used to determine futility in massively transfused trauma patients. J Trauma. 2011 Aug; 71(2):S364-369. PMID: 21814105. 316. Spoerke N, Michalek J, Schreiber M, Trauma Outcomes Group. Crystalloid resuscitation improves survival in trauma patients receiving low ratios of fresh frozen plasma to packe red blood cells. J Trauma. 2011 Aug; 71(2):S380-383. PMID: 21814108. 317. Brown LM, Call MS, Knudson MM, Cohen MJ, Trauma Outcomes Group. A normal platelet count may not be enough: The impact of admission platelet count on mortality and transfusion in severely injured trauma patients. J Trauma. 2011 Aug; 71(2):S337-342. PMID: 21814101. 318. Brown, LM, Aro SO, Cohen MJ, Trauma Outcomes Group. A high fresh frozen plasma: Packed red blood cell transfusion ratio decreases mortality in all massively transfused trauma patients regardless of admission international normalized ratio. J Trauma. 2011 Aug; 71(2):S358-363. PMID: 21814104. 319. Rowell SE, Barbosa RR, Diggs BS, Schreiber MA, Trauma Outcomes Group. Effect of high product ratio massive transfusion on mortality in blunt and penetrating trauma patients. J Trauma. 2011 Aug; 71(2):S353-357. PMID: 21814103. 320. Rowell SE, Barbosa RR, Allison CE, Van PY, Schreiber MA, Trauma Outcomes Group. Gender-based differences in mortality in response to high product ratio massive transfusion. J Trauma. 2011 Aug; 71(2):S375-379. PMID: 21814107. 321. Spinella PC, Doctor A, Blumberg N, Holcomb JB. Does the storage duration of blood products affect outcomes in critically ill patients? Transfusion. 2011 Aug;51(8):1644-50. PMID: 21831180. 322. Brasel KJ, Vercruysse G, Spinella PC, Wade CE, Blackbourne LH, Borgman MA, Zarzabal LA, Du F, Perkins JG, Maegele M, Schreiber M, Hess JR, Jastrow KM 3rd, Gonzalez EA, Holcomb JB, Kozar RA; Trauma Outcomes Groups. The association of blood component use ratios with the survival of massivey transfused trauma patients with and without severe brain injury. J Trauma. 2011 Aug;71(2 Suppl 2)S34352. PMID: 21814102. 323. Hospenthal DR, Murray CK, Andersen RC, Bell RB, Calhoun JH, Cancio LC, Cho JM, Chung KK, Clasper JC, Colyer MH, Holcomb JB, et al. Guidelines for the prevention of infections associated with combat-related injuries: 2011 update: endorsed by the Infectious Diseases Society of America and the Surgical Infection Society. J Trauma. 2011 Aug;71(2 Suppl 2):S210-34. PMID: 21814089. 324. Hospenthal DR, Murray CK, Andersen RC, Bell RB, Calhoun JH, Cancio LC, Cho JM, Chung KK, Clasper JC, Colyer MH, Holcomb JB, et al. Executive summary: Guidelines for the prevention of infections associated with combat-related injuries: 2011 update: endorsed by the Infectious Diseases Society of America and the Surgical Infection Society. J Trauma. 2011 Aug;71(2 Suppl 2):S202-9. PMID: 21814088. 39

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325. Cotton BA, Kao LS, Kozar RA, Holcomb JB. Cost-utility analysis of levetiracetam and phenytoin for posttraumatic seizure prophylaxis. J Trauma. 2011 Aug;71(2):375-9. PMID: 21825941. 326. Cotton BA, Faz G, Hatch QM, Radwan ZA, Podbielski J, Wade CE, Kozar RA, Holcomb JB. Rapid thrombelastography delivers real-time results that predict transfusion within 1 hour of admission. J Trauma. 2011 Aug;71(2):407-17. PMID: 21825945. 327. Holcomb JB. A novel and potentially unifying mechanism for shock induced early coagulopathy. Ann Surg. 2011 Aug;254(2):201-2. PMID: 21694580. 328. Cotton BA, Reddy N, Hatch QM, Lefebre E, Wade CE, Kozar RA, Gill BS, Albarado R, McNutt MK, Holcomb JB. Damage control resuscitation is associated with a reduction in resuscitation volumes and improvement in survival in 390 damage control laparotomy patients. Ann Surg. 2011 Oct;254(4):598-605. PMID: 21918426. 329. Kragh JF Jr, O’Neill ML, Walters TJ, Dubick MA, Baer DG, Wade CE, Holcomb JB, Blackbourne LH. The military emergency tourniquet program’s lessons learned with devices and designs. Mil Med. 2011 Oct; 176(10):1144-52. PMID: 22128650. 330. Darlington DN, Delgado AV, Kheirabadi BS, Fedyk CG, Scherer MR, Pusateri AE, Wade CE, Cap AP, Holcomb JB, Dubick MA. Effect of Hemodilution on Coagulatio and Recombinant Factor VIIa Efficacy in Human Blood In Vitro. J Trauma. 2011 Nov;71(5):1152-63. PMIC: 21610535. 331. Letourneau PA, McManus M, Sowards K, Wang W, Wang YW, Matijevic N, Pati S, Wade CE, Holcomb JB. Aged Plasma transfusion increases mortality in a rat model of uncontrolled hemorrhage. J Trauma. 2011 Nov; 71(5):1115-9. PMID: 22071917. 332. Cotton BA, McCarthy KK, Holcomb JB. Acutely injured patients on dabigatran. N Eng J Med. 2011 Nov 24; 365(21):2039-40. PMID: 22111735. 333. Hatch QM, Osterhout LM, Podbielski J, Kozar RA, Wade CE, Holcomb JB, Cotton BA. Impact of closure at the first take back: Complication burden and potential overutilization of damage control laparotomy. J Trauma. 2011 Dec;71(6):1503-11. PMID: 22182860. 334. Inaba K, Branco BC, Rhee P, Blackbourne LH, Holcomb JB, Spinella PC, Shulman I, Nelson J, Demetriades D. J Trauma 2011 Dec; 71(6):1766-73; discussion 1773-4. PMID: 22182887. 335. Kragh JF Jr, Littrel ML, Jones JA, Walters TJ, Baer DG, Wade CE, Holcomb JB. Battle casualty survival with emergency tourniquet use to stop limb bleeding. J Emerg Med. 2011 Dec; 41(6):590-7. PMID: 19717268. 336. Kotwal RS, Montgomery HR, Kotwal BM, Champion HR, Butler FK Jr, Mabry RL, Cain JS, Blackbourne LH, Mechler KK, Holcomb JB. Arch Surg. 2011 Dec; 146(12):1350-8. PMID: 21844425. 337. Holcomb JB. Minimal transfusions: comment on “Surgical outcomes and transfusion of minimal amounts of blood in the operating room.” Arch Surg. 2012 Jan; 147(1):55-6. PMID: 22250114.

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338. Ho AM, Dion PW, Yeung JH, Holcomb JB, Critchley LA, Ng CS, Karmaker MK, Cheung CW, Rainer TH. Prevalence of survivor bias in observational studies on fresh frozen plasma: Erthrocyte ratios in trauma requiring massive transfusion. Anesthesiology 2012 Mar;116(3):716-28. PMID: 22270506. 339. Holcomb JB. Associated injuries in casualties with traumatic lower extremity amputations caused by explosive devices. Br J Surg. 2012 Mar; 99(3):367. PMID: 22287073 340. Rahbar MH, Fox EE, del Junco DJ, Cotton BA, Podbielski JM, Matijevic N, Cohen MJ, Schreiber MA, Zhang J, Mirhaji P, Duran S, Reynolds RJ, Benjamin-Garner R, Holcomb JB; The PROMMTT Investigators. Resuscitation. 2012 Apr;83(4):459-64. PMID: 22001613. 341. Kim S, Kang Y, Krueger CA, Sen M, Holcomb JB, Chen D, Wenke JC, Yang Y. Sequential delivery of BMP-2 and IGF-1 using a chitosan gel with gelatin microspheres enhances early osteoblastic differentiation. Acta Biomater. 2012 May;8(5):1768-77. PMID: 22293583.. 342. Dossett LA, Fox EE, del Junco DJ, Zaydfudim V, Kauffmann R, Shelton J, Wang W, Cioffi WG, Holcomb JB, Cotton BA. Don’t forget the posters! Quality and content variables associated with accepted abstracts at a national trauma meeting. J Trauma Acute Care Surg. 2012 May;72(5):1429-34. PMID: 22673278. 343. Mace JE, Park MS, Mora AG, Chung KK, Martini W, White CE, Holcomb JB, Merrill GA, Dubick MA, Wolf SE, Wade CE, Schwacha MG. Differential expression of the immunoinflammatory response in trauma patients: Burn vs. Non-Burn. Burns. 2012 Jun;38(4):599-606. PMID: 22103986. 344. Cotton BA, Minei FM, Radwan ZA, Matijevic N, Pivalizza E, Podbielski J, Wade CE, Kozar RA, Holcomb JB. Admission rapid thrombelastography predicts development of pulmonary embolism in trauma patients. J Trauma Acute Care Surg. 2012 Jun;72(6):1470-7. PMID: 22695409. 345. Carson JL, Grossman BJ, Kleinman S, Tinmouth AT, Marques MB, Fung MK, Holcomb JB, Illoh O, Kaplan LJ, Katz LM, Rao SV, Roback JD, Shander A, Tobian AA, Weinstein R, Swinton McLaughtlin LG, Djulbegovic B; for the Clinical Transfusion Medicine Committee of the AABB. Red Cell Transfusion: A Clinical Practice Guideline from the AABB. Ann Intern Med., 2012 Jul 3;157(1):49-58. PMID: 22454395. 346. Perkins JG, Brosch LR, Beekley AC, Warfield KL, Wade CE, Holcomb JB. Research and analystics in combat trauma care: converting data and experience to practical guidelines. Surg Clin North Am. 2012 Aug;92(4):1041-54. PMID: 22850161. 347. Cotton BA, Harvin JA, Kostousouv V, Minei KM, Radwan ZA, Schochl H, Wade CE, Holcomb JB, Matijevic N. Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration. J Trauma Acute Care Surg. 2012 Aug;73(2):365-70. PMID: 22846941. 348. Holcomb JB, Minei KM, Scerbo ML, Radwan ZA, Wade CE, Kozar RA, Gill BS, Albarado R, McNutt M, Khan S, Adams PR, McCarthy JJ, Cotton BA. Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: experience with 1974 consecutive trauma patients. Ann Surg. 2012 Sep;256(3):476-86. PMID: 22868371.

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349. Kostousov V, Wang YW, Wade CE, Holcomb JB, Cotton BA, Matijevic N. Hemostatically distinct FFPs equally improve abnormal TEG variables in an in vitro dilutional coagulopathy model. Thromb Res., 2012 Sep;130(3):429-34. PMID: 22386721. 350. Matin NJ, Dubose JJ, Rodriguez C, Dorlac WC, Beilman GJ, Rasmussen TE, Jenkins DH, Holcomb JB, Pruitt BA. One Front and One Battle: Civilian Professional Medical Support of Military Surgeons. J Am Coll Surg. 2012 Sep;215(3):432-7. PMID: 22683071 351. Kirkpatrick AW, Holcomb JB, Stephens MH, Gruen R; Members of the Evidence-Based Reviews in Surgery Group. Tranexamic acid effects in trauma patients with significant hemorrhage. J Am Coll Surg. 2012 Sep;215(3):438-40. PMID: 22901513. 352. Holcomb JB, Del Junco DJ, Fox EE, Wade CE, Cohen MJ, Schreiber MA, Alarcon LH,Bai Y, Brasel KJ, Bulger EM, Cotton BA, Matijevic N, Muskat P, Myers JG, Phelan HA, White CE, Zhang J, Rahbar MH; for the PROMMTT Study Group. The Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) Study: Comparative Effectiveness of a Time-Varying Treatment With Competing Risks. Arch Surg. 2012 Oct 15:1-10. [Epub ahead of print]. PMID:23070371. 353. Menge T, Zhao Y, Zhao J, Wataha K, Gerber M, Zhang J, Letourneau P, Redell J, Shen L, Wang J, Peng Z, Xue H, Kozar R, Cox CS Jr, Khakoo AY, Holcomb JB, Dash PK, Pati S. Mesenchymal Stem Cells Regulate Blood-Brain Barrier Integrity Through TIMP3 Release After Traumatic Brain Injury. Sci Transl Med. 2012 Nov 21;4(161):161ra150. PMID: 23175708. 354. Harvin JA, Harvin WH, Camp E, Caga-Anan Z, Burgess AR, Wade CE, Holcomb JB, Cotton BA. Early femur fracture fixation is associated with a reduction in pulmonary complications and hospital charges: A decade of experience with 1,376 diaphyseal femur fractures. J Trauma Acute Care Surg. 2012 Dec;73(6):1440-7. PMID: 23188236. 355. Dua A, Patel B, Kragh JF Jr, Holcomb JB, Fox CJ. Long-term follow-up and amputation-free survival in 497 casualties with combat-related vascular injuries and damage-control resuscitation. J Trauma Acute Care Surg. 2012 Dec;73(6):1515-20. PMID: 23188245. 356. Blackbourne LH, Baer DG, Eastridge BJ, Kheirabadi B, Kragh JF Jr, Cap AP, Dubick MA, Morrison JJ, Midwinter MJ, Butler FK, Kotwal RS, Holcomb JB. Military medical revolution: Prehospital combat casualty care. J Trauma Acute Care Surg. 2012 Dec;73(6 Suppl 5):S372-7. PMID:23192058. 357. Eastridge BJ, Mabry RL, Seguin P, Cantrell J, Tops T, Uribe P, Mallett O, Zubko T, Oetjen-Gerdes L, Rasmussen TE, Butler FK, Kotwal RS, Holcomb JB, Wade C, Champion H, Lawnick M, Moores L, Blackbourne LH. Death on the battlefield (2001-2011): Implications for the future of combat casualty care. J Trauma Acute Care Surg. 2012 Dec;73(6 Suppl 5):S431-7. PMID: 23192066. 358. Blackbourne LH, Baer DG, Eastridge BJ, Renz EM, Chung KK, Dubose J, Wenke JC, Cap AP, Biever KA, Mabry RL, Bailey J, Maani CV, Bebarta V, Rasmussen TE, Fang R, Morrison J, Midwinter MJ, Cestero RF, Holcomb JB. Military medical revolution: deployed hospital and en route care. J Trauma Acute Care Surg. 2012 Dec;73(6 Suppl 5):S378-87. Review. PMID:23192059. 359. Blackbourne LH, Baer DG, Eastridge BJ, Butler FK, Wenke JC, Hale RG, Kotwal RS, Brosch LR, Bebarta VS, Knudson MM, Ficke JR, Jenkins D, Holcomb JB. Military medical revolution: military trauma system. J Trauma Acute Care Surg. 2012 Dec;73(6 Suppl 5):S388-94. PMID:23192060. 42

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360. Wataha K, Menge T, Deng X, Shah A, Bode A, Holcomb JB, Potter D, Kozar R, Spinella PC, Pati S. Spray-dried plasma and fresh frozen plasma modulate permeability and inflammation in vitro in vascular endothelial cells. Transfusion. 2013 Jan;53 Suppl 1:80S-90S. PMID:23301978. 361. Callcut RA, Cotton BA, Muskat P, Fox EE, Wade CE, Holcomb JB, Schreiber MA, Rahbar MH, Cohen MJ, Knudson MM, Brasel KJ, Bulger EM, Del Junco DJ, Myers JG, Alarcon LH, Robinson BR; PROMMTT Study Group. Defining when to initiate massive transfusion: a validation study of individual massive transfusion triggers in PROMMTT patients. J Trauma Acute Care Surg. 2013 Jan;74(1):59-65, 67-8; discussion 66-7. PMID: 23271078. 362. Matijevic N, Wang YW, Cotton BA, Hartwell E, Barbeau JM, Wade CE, Holcomb JB. Better hemostatic profiles of never-frozen liquid plasma compared with thawed fresh frozen plasma. J Trauma Acute Care Surg. 2013 Jan;74(1):84-90; discussion 90-1. PMID: 23271081. 363. Dubose JJ, Scalea TM, Holcomb JB, Shrestha B, Okoye O, Inaba K, Bee TK, Fabian TC, Whelan J, Ivatury RR; AAST Open Abdomen Study Group. Open abdominal management after damage-control laparotomy for trauma: a prospective observational American Association for the Surgery of Trauma multicenter study. J Trauma Acute Care Surg. 2013 Jan;74(1):113-20; discussion 1120-2. PMID: 23271085. 364. Radwan ZA, Bai Y, Matijevic N, Del Junco DJ, McCarthy JJ, Wade CE, Holcomb JB, Cotton BA. An emergency department thawed plasma protocol for severely injured patients. JAMA Surg. 2013 Feb 1;148(2):170-5. PMID: 23426594. 365. Harvin JA, Mims MM, Duchesne JC, Cox CS Jr, Wade CE, Holcomb JB, Cotton BA. Chasing 100%: The use of hypertonic saline to improve early, primary fascial closure after damage control laparotomy. J Trauma Acute Care Surg. 2013 Feb;74(2):426-32. PMID: 23354234. 366. Kostousov V, Wang YW, Cotton BA, Wade CE, Holcomb JB, Matijevic N. Influence of resuscitation fluids, fresh frozen plasma and antifibrinolytics on fibrinolysis in a thrombelastography-based, in-vitro, whole-blood model. Blood Coagul Fibrinolysis. 2013 Feb 12. [Epub ahead of print] PMID: 23406662. 367. Holcomb JB, Gumbert S. Potential value of protocols in substantially bleeding trauma patients. Curr Opin Anaesthesiol. 2013 Apr;26(2):215-20. PMID: 23385320.

BOOK CHAPTERS 1.

Mabry R and Holcomb JB. Trauma Assessment. In Whitlock WL, ed. Special Operations Forces Medical Handbook, Jackson, WY: Teton New Media, 2001.

2.

Greydanus D and Holcomb JB. Field Appendectomy. In Whitlock WL, ed. Special Operations Forces Medical Handbook, Jackson, WY: Teton NewMedia, 2001.

3.

Holcomb JB. Combat Triage. NATO Emergency War Surgery Handbook. Chapter 3, pp 3.1-3.17, 3rd Edition, Borden Institute, US Department of Defense, 2004. 43

Holcomb, J.B. CV March 2013

BOOK CHAPTERS (CONTINUED): 4.

Holcomb JB. In Valadka A, ed. Neurosurgery, Clinical Practice. Simultaneous Intracranial and Abdominal Injuries: Which Gets Operated on First, and Which Has the Higher Treatment Priority? In Valadka AB and Andrews BT (eds). Neurotrauma: Evidence Based Answers to Common Questions. Chapter 31, pp 175-178., New York:Thieme 2005.

5.

Baskin TW, Holcomb JB. Bombs, Mines, Blast, Fragmentation and Thermobaric mechanisms of injury. In Mahoney PF, Ryan JM, Brooks AJ, Schwab CW (eds.),Ballistic Trauma: A Practical Guide. 2nd ed., Springer-Verlag, 2005.

6.

Zimrin AB, Holcomb JB, Hess Jr. Hemorrhage Control and Thrombosis Following Severe Injury. Chapter 47 in Kitchens CS, Alving BM, Kestler CM eds. Consultative Hemostasis and Thrombosis, 2nd Edition. Philadelphia, Saunders, 2006.

7.

McMullin NR, Holcomb JB, Sondeen J. Hemostatic Resuscitation. In: Yearbook of Intensive Care and Emergency Medicine 2006. Springer-Verlag Berlin Heidelberg, 2006;265-278.

8.

Jenkins DH, Holcomb JB. Resuscitation. Chapter 162 in Irwin RS, Rippe JM, eds. Intensive Care Medicine, 6th Edition. Philadelphia, Pa, Lippincott Williams & Wilkins, 2008.

9.

Jenkins DH, Holcomb JB, Letourneau PA, Smoot DL, Barnes SL. Resuscitation from Shock Following Injury. In Irwin and Rippe’s Intensive Care Medicine. 7th Edition. Philadelphia, PA, Lippincott Williams and Wilkins, 2011.

10.

Letourneau PA, Holcomb JB. Colon and Rectal Trauma to Include Foreign Bodies. In Bailey et al. Colorectal Surgery. 1st Ed. In Press

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Holcomb, J.B. CV March 2013

PRESENTATIONS: INTERNATIONAL Hetz S, Holcomb J. Combined Laparoscopic Exploration and Repair of Inguinal Hernias. Emerging Surgical Technologies, Versailles, France, March, 1996. Holcomb JB. Forward Surgery in the U.S. Military. International Committee of the Red Cross Symposium on Prehospital Care of the War Wounded, Geneva Switzerland, November 1998. Holcomb JB. Dry Fibrin Sealant Dressings Reduce Blood Loss, Resuscitation Volume and Improve Survival in Hypothermic Coagulopathic Swine with Grade V Liver Injuries. Plasma Products Biotechnology Meeting, 1999, Queensland, Australia, 29 March 1999. Holcomb JB. Efficacy of Fibrin Foam to Decrease Bleeding from Severe Liver Injuries. Plasma Products Biotechnology Meeting, 1999, Queensland, Australia, 29 March 1999. Holcomb JB. Managing the Massively Bleeding Patient. VI Regional European Congress of the International Society of Blood Transfusion, Jerusalem, Israel, 11 May 1999. Holcomb JB, Schreiber MA. Experimental Use of NovoSeven®: Experiences from Animal Models. 6th Novo Nordisk Symposium on Treatment of Bleeding and Thrombotic Disorders, Copenhagen, Denmark, 3-4 May 2001. Holcomb JB. Damage Control Techniques. Definitive Surgical Trauma Skills. Royal College of Surgeons, London, England, 20-22 November 2001. Holcomb JB, McMullin NR, Kozar RA, Lygas MH, Wright SL, Wright BK, Domonoske BD, Macaitis JM, Sailors RM, Moore FA. Morbidity from Rib Fractures Increases after Age 45. Oral presentation at the Western Trauma Association, Whistler, Canada, 24 February-1 March 2002. Holcomb JB. Trauma Symposium in Iraq, May-June 2003. Holcomb JB, Butler F, Geibner S. Tactical Combat Casualty Care Workshop. Presented at the 4th World Congress on Wilderness Medicine, Whistler British Columbia, Canada, 9-13 August 2003. Holcomb JB. Trauma Symposium in Iraq, Jan, 2004. Holcomb JB. Management of Massive Disasters. Oral Presentation at the 6th World Congress on Trauma, Shock, Inflammation and Sepsis – Pathophysiology, Immune Consequences and Therapy, Munich, Germany, 2-6 March 2004. Holcomb JB. Prehospital Endpoints of Resuscitation. Oral Presentation at the 24th International Symposium on Intensive and Emergency Medicine, Brussels, Belgium, 30 March- 2 April 2004. Holcomb JB. Hemorrhage Control Techniques in Trauma. Oral Presentation at the 24th International Symposium on Intensive and Emergency Medicine, Brussels, Belgium, 30 March-2 April 2004. Holcomb JB. Trauma Symposium in Iraq, May-June, 2004. 45

Holcomb, J.B. CV March 2013

INTERNATIONAL (CONTINUED): Holcomb JB. A U.S. Perspective: Recent Experience in Iraq. Oral Presentation at the Management of Battlefield Tissue Injury, Toronto, Canada, 28-29 June 2004. Holcomb JB. Hemostatic Resuscitation: Military Experience. Oral Presentation, Trauma, Shock, Inflammation and Sepsis (TSIS) 2007, Munich, Germany, 16 March 2007. Holcomb JB. Trauma-Trials in the Battlefield. Oral Presentation, Trauma, Shock, Inflammation and Sepsis (TSIS) 2007, Munich, Germany, 17 March 2007. Holcomb JB. Hemostasis, Plenary Session. Oral Presentation, Blast Injury Expert Symposium, London, UK, 12 June 2007. Holcomb JB. Trauma Registries and Outcome, the Trauma Registry from Iraq: Use and Early Results. Oral Presentation, International Shock Congress, Cologne, Germany, 2 July 2008. Holcomb JB. New Directions in the Management of Trauma Induced Coagulopathy, Looking to the Future of Resuscitation. Oral Presentation, International Shock Congress, Cologne, Germany, 2 July 2008. Holcomb JB. Innovations and lessons from combat casualty care that can be learned by the NHS. Healthcare Innovation Expo 2009. London, England, 18 June, 2009. Holcomb JB. Is the FFP:RBC ratio the answer? International Symposium on Critical Bleeding. Copenhagen, Denmark, 24 August 2009. Holcomb JB. Use of tourniquets. International Trauma Conference, Manchester, England, October 2009. Holcomb JB. Massive Transfusion Protocol for Coagulopathy: What have we learned so far? International Trauma Conference, Manchester, England, October 2009. Holcomb JB. Damage Control Resuscitation. Landstuhl Regional Medical Center Grand Rounds, Landstuhl, Germany, December 2010. Holcomb JB. The Military’s Approach to Hemostasis in Wounded Soldiers. London 2011 Workshop: New Products and Their Implications, London, England, 9-11 January 2011 Holcomb JB. Coagulopathy of Major Trauma. International Symposium on Critical Bleeding, Copenhagen, Denmark, 5-6 September 2011. Holcomb JB. Transportation of the Traumatized Patient. IberoAmerican Critical Care Meeting, Cartagena, Columbia, 29 November – 2 December 2011. Holcomb JB. DCR Today-A Surgeon’s Perspective/Don’t Waste Time on Conventional Coagulation Tests – Use TEG/Hybrid OR Approach by Trauma Surgeons. Norwegian Surgical Society, Oslo, Norway, 22 October – 23 October 2012.

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NATIONAL: Holcomb J, Carey S. Malignant Biliary Papillomatosis. Gary Wratten Surgical Symposium, San Francisco, CA, 1991. Holcomb J and Remar M. Thoracoscopy: First-Year Experience at an Army Medical Center, Gary Wratten Surgical Symposium, 1993. Holcomb J. Laparoscopic Hernia Repair. Experience at Womack Army Medical Center, Gary Wratten Surgical Symposium, April, 1994. Holcomb J. Advanced Technology for Combat Casualty Care. Advanced Technology Applications to Combat Casualty Care, Washington, DC, April, 1995. Holcomb J. Lessons Re-learned from Somalia. 2nd Annual Army Trauma Meeting, San Antonio, TX, September, 1995. Craig R, Holcomb J. Laparoscopic Repair of Common Bile Duct Injury Using Fibrin Glue in the Porcine Model. Society of Laparoendoscopic Surgeons, Orlando, FL, 7 December 1995. Holcomb J. Dry Fibrin Sealant Dressing for Hemorrhage Control after Ballistic Injury. Presented at International Fibrin Sealant Meeting, La, Jolla, CA, April, 1996. Holcomb J. Lessons Learned from Somalia, 1993. Military Medicine Grand Rounds, Uniformed Services University of the Health Sciences, Bethesda, MD, May, 1996. Nessen S, Holcomb J. Patient Satisfaction after Laparoscopic and Open Nissen Fundoplication. Society of Laparoendoscopic Surgeons, Orlando, FL, December, 1996. Holcomb J. Overview of Dry Fibrin Sealant Dressings for Hemorrhage Control. Special Operations Medical Association, Fayetteville, NC, December, 1996. Chorens A, Holcomb J, Hetz S. A Prospective, Randomized Comparison of Inguinal Herniorrhaphy: Laparoscopic Preperitoneal vs Open Tension Free vs Open Traditional. 18th Annual Gary P. Wratten Surgical Symposium, Coronado, CA, 9-11 April, 1997. Holcomb J. Differences in Civilian and Military Trauma. Shock Society, Rio Rancho, CA, June, 1997. Holcomb J, Pusateri A. Dry Fibrin Sealant Dressings for Hemorrhage Control. Shock Society, Rio Rancho, CA, June, 1997. Lein B, Holcomb J, Hetz S. Removal of Unexploded Ordinance: Current Recommendations. 3rd Annual Army Trauma Symposium, San Antonio, TX, 24-26 August 1997. Nessen S, Holcomb J, Hetz S. Treatment Algorithm for Severe Gastroesophageal Reflux Disease Based on Efficacy and Cost Analysis. Society of Laparoendoscopic Surgeons, Endo Expo ‘97, Orlando, FL, 3-6 December 1997.

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NATIONAL (CONTINUED): Holcomb JB. Initial Management of Shock and Hemorrhage Control. Vascular Trauma, Current Concepts, Novel Techniques, and Evolving Technologies, San Antonio, TX, 21 May 1998. Holcomb J, Pusateri A, Hess J, MacPhee M. Dry Fibrin Sealant Dressings for Hemorrhage Control in Swine with Severe Liver Injuries. Oral presentation at the American Association for the Surgery of Trauma, Baltimore, MD, 26 September 1998. Holcomb JB, Pusateri A, Harris R, Reid T, Hess J, MacPhee M. Dry Fibrin Sealant Dressings Reduce Blood Loss, Resuscitation Volume and Improve Survival in Hypothermic Coagulopathic Swine with Grade V Liver Injuries. Oral presentation at the Eastern Association for the Surgery of Trauma, Orlando, FL, 15 January 1999. Holcomb JB. Lessons Relearned from Somalia, 1993: One surgeon’s perspective. American College of Emergency Physicians, San Antonio, TX, 15 March 1999. Holcomb JB. The Army Medic of the Future. Colonel John R. Sperandio Plans, Operations, Intelligence, Training, and Security Postgraduate Short Course, Dallas, TX, 26 April 1999. Martin RR, Alvarez J, Holcomb JB. Civilian Urban Trauma Experience Approximates Injuries Seen in War for Abdominal Injuries. Presented at the Gary P Wratten, Tacoma, WA, 7 May 1999. Ellison RW, Holcomb JB, Pusateri AE, Macaitis JM, Brinkley WW, Baskin TW. Hemodynamic and Metabolic Effects of Resuscitation in an Uncontrolled Hemorrhage Model of Severe Rat Liver Injury. Presented at the Gary P Wratten, Tacoma, WA, 7 May 1999. Holcomb JB. Prehospital Care in the 21st Century. American College of Emergency Physicians, Houston, TX, 18 February 2000. Stamateris C, Holcomb JB. Nursing Implications of Damage Control Surgery. 5th Annual Army Trauma Conference. San Antonio, TX, 22 August 2000. Holcomb J. NATO Civil-Military Blood Conference. Surgical training, Blood Use and Hemorrhage control. Washington D.C., 9 November 2000. Holcomb JB. Management of Penetrating Injuries on the Battlefield. Navy Medicine Trauma Symposium. San Diego, CA, 16 November 2000. Holcomb JB. Dry Fibrin Sealant Dressings Reduce Blood Loss, Resuscitation Volume and Improve Survival in Hypothermic Coagulopathic Swine with Grade V Liver Injuries. Michael E DeBakey International Surgical Society XIII Congress, Houston, TX, 19-21 November 2000. Holcomb JB. Intravenous rFVIIa Administered for Hemorrhage Control in Hypothermic Coagulopathic Swine with Grade V Liver Injuries. Michael E DeBakey International Surgical Society XIII Congress, Houston, TX, 19-21 November 2000.

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NATIONAL (CONTINUED): Holcomb JB. New Techniques for Improved Hemorrhage Control. Surgery Grand Rounds, Baltimore Shock Trauma, University of Maryland, Baltimore, Maryland, 21-22 January 2001. Holcomb JB. Pre-Hospital Combat Fluid Resuscitation Strategy: One of the Lessons Learned in Mogadishu, Somalia. Combat Fluid Resuscitation 2001. USUHS, Bethesda, MD, 18-20 June 2001. Holcomb JB, Dumire RD, Crommett JW, Stamateris CE, Fagert MA, Cleveland JA, Dorlac GR, Dorlac WC, Mattox KL. Evaluation of Trauma Team Performance Using an Advanced Human Patient Simulator for Resuscitation Training. Accepted for Oral presentation at the American Association for the Surgery of Trauma, Seattle, WA, 14 September 2001. Holcomb JB. Combined Techniques for Improved Hemorrhage Control. 7th International Tissue Sealants Conference, New Orleans, LA, 6-7 October 2001. Dumire RD, Crommett JW, Holcomb JB, Stamateris CE, Fagert MA, Cleveland JA, Dorlac GR, Dorlac WC, Mattox KL. Evaluation of Trauma Team Performance Using an Advanced Human Patient Simulator for Resuscitation Training. Oral presentation at the American College of Surgeons, Surgical Forum, New Orleans, LA, 7-12 October 2001. Holcomb JB. New Approaches for Managing Catastrophic Bleeding in the Emergency Department. American College of Emergency Physicians, Breakfast Symposium, Chicago, IL, 15 Oct 2001. Holcomb JB. Evaluation of Surgical Training Using Simulation. Medicine, Technology and Human Factors in Trauma Care: A Civilian/Military Perspective. University of Maryland, Baltimore, Maryland, 15-16 November 2001. Holcomb JB. Non-Invasive Pre-Hospital Data Collection. Medicine, Technology and Human Factors in Trauma Care: A Civilian/Military Perspective. University of Maryland, Baltimore, Maryland, 15-16 November 2001. Schreiber MA, Holcomb JB, Brundage SI, Macaitis JM, Tweardy DJ, Hedner U, Hoots K. The Effect Of Recombinant Factor VIIa on Coagulopathic Pigs with Grade V Liver Injuries. Oral presentation at Eastern Association for the Surgery of Trauma, Tampa Bay, FL, 15-19 January 2002. Brundage SI, Schreiber MA, Mastrangelo MA, Holcomb JB, Maciatis JM, Moreno CE, Tweardy DJ. Uncontrolled Hemorrhagic Shock in A Porcine Model Leads to Upregulation of the Proinflammatory Cytokines IL-6 and G-CSF and Hepatic Necrosis. Oral presentation at Eastern Association for the Surgery of Trauma, Tampa Bay, FL, 15-19 January 2002. Holcomb JB, Neville HL, Fischer CF, Hoots K. Use of Recombinant FVIIa for Intraperitoneal Coagulopathic Bleeding in a Septic Patient. Oral Presentation at the 24th Annual Gary P Wratten Surgical Symposium, Washington, D.C., 8-10 April 2002.

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NATIONAL (CONTINUED): Niles SE, Holcomb JB, Miller CC, Hinds D, Aoki N, Salinas J, Flannigan TJ, Macaitis JM, Duke JH, Moore FA. Pre-Hospital Physiologic Data and Life-Saving Interventions in Trauma Patients. Oral Presentation at the 24th Annual Gary P Wratten Surgical Symposium, Washington, D.C., 8-10 April 2002. Brundage SI, Schreiber MA, Holcomb JB, Mastrangelo MA, Xu XQ, Macaitis J, Tweardy DJ. Amplification of the Pro-Inflammatory Transcription Factor Cascade Increases With Severity Of Uncontrolled Hemorrhage in Swine. Oral presentation at the Association for Academic Surgery, Boston, MA, November, 2002. Kozar RA, Holcomb JB, Macatis J, DeSoignie R, Moore FA. Superior Mesenteric Artery Occlusion (SMAO) Models Shock-Induced Gut Ischemia/Reperfusion. Oral presentation at the Association for Academic Surgery, Boston, MA, November, 2002. Holcomb JB. Operation Iraqi Freedom (OIF) AAR, Oral Presentation at the Advanced Technology Applications for Combat Casualty Care Annual (ATACCC) Conference, St. Petersburg, FL, 16-22 August 2003. Holcomb JB. Improved Hemorrhage Control on the Battlefield, Oral Presentation at the Institute for Defense and Government Advancement (IDGA), Battlefield Healthcare Conference, Chairman, Arlington, VA, 14-17 September 2003. Holcomb JB. Advances in Hemostasis and the Military Approach to Injuries and Trauma: The First 24 Hours. Oral Presentations at the 6th Annual Steven R. Hall, Trauma Symposium, Ridgedale, MO, 2-4 October 2003. Holcomb JB. Trauma Surgery in Military and Urban Arenas of Warfare. Oral Presentation at the 2003 American College of Surgeons 89th Annual Clinical Congress, Chicago, IL, 19-23 October 2003. Martini WZ, Uscilowicz JM, Pusateri AE, Delgado AV, Holcomb JB. Independent Contributions of Hypothermia and Acidosis to Coagulopathy in Swine. Oral Presentation at the Eastern Association for the Surgery of Trauma, Amelia Island, FL, Jan, 2004. Holcomb JB. Prediction for Need of Life Saving Interventions Based on Pre-Hospital Trauma Patient Data: Implications for Combat Casualty Care, Oral Presentation at the Advanced Technology Applications for Combat Casualty Care Annual (ATACCC) Conference, St. Petersburg, FL, 18 August 2004. Holcomb JB. Trauma Update. Oral Presentation at the 10th Annual Field Medicine Conference “Health Service Support in OIF & OEF: Lessons Learned,” Raleigh, NC, 9 September 2004. Holcomb JB. An Update on Iraq: Resuscitation and Evacuation. Oral Presentation at the Hutchinson Technology Inc., 2nd Annual Directors’ Forum, Maui, Hawaii, 30 September 2004. Holcomb JB. Current Perspective on Combat Casualty Care. William T Fitts Lecture at the American Association for the Surgery of Trauma, Maui, Hawaii, 29 September-1 October 2004. Holcomb JB. U.S. Army in Iraq. Oral Presentation at the American College of Surgeons, 90th Annual Clinical Congress, New Orleans, LA, 10-14 October 2004. 50

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NATIONAL (CONTINUED): Holcomb JB. Adjuncts to Cessation of Bleeding: Fibrin Sealants and rFVIIa. Oral Presentation at the American College of Surgeons, 90th Annual Clinical Congress, New Orleans, LA, 10-14 October 2004. Holcomb JB. Co-Moderator in the Thrombovascular Resuscitation Session of the Resuscitation Science Symposium (ReSS), New Orleans, LA, 6 November 2004. Holcomb JB, Cancelada, DA, Cancio, L, Chavez, T, Eastridge, B, Owsley, J. Army Plenary Session for 2004 Association of Military Surgeons of the United States (AMSUS), Trauma Care on the Battlefield Panel Discussion, Denver, CO, 15 November 2004. Holcomb JB. Clinical Issues Facing Soldiers at War. Oral Presentation at the Association of Military Surgeons of the United States (AMSUS), Denver, CO, 16 November 2004. Holcomb JB. Manual Vital Signs Reliably Predict Need for Life Saving Interventions in Trauma Patients. Oral Presentation, Eastern Association for the Surgery of Trauma, Fort Lauderdale, FL, 12 January 2005. Holcomb JB. What’s New in Combat Casualty Trauma Care: Lessons Learned and Future Directions. Oral Presentation, Government Services Joint Services Symposium, San Antonio, TX, 4 April 2005. Holcomb JB. Human Effects of Explosions in Iraq. Oral Presentation, National Blast Injury Awareness Conference, Alexandria, VA, 9 May 2005 Holcomb JB. Prehospital Heart Rate Variability and Mortality. Oral Presentation, 28th Annual Conference on Shock, Marco Island, FL, 5 June 2005. Holcomb JB. Theater Trauma Registry/System to Include Advances in Combat Casualty Care. Oral Presentation, 2005 AUSA Medical Symposium, San Antonio, TX, 28 June 2005. Holcomb JB. KIA and Dow Rates in Iraq and Afghanistan – How are we Doing?” Oral Presentation, 2005 AUSA Medical Symposium, San Antonio, TX, 28 June 2005. Holcomb JB. Combat Trauma Management: What are the Applications in the Civilian Populations? Oral Presentation, Health Answers Education, Managing Trauma: Expert Opinions on State of the Art and Potential Future, Atlanta, GA, 22 September 2005. Holcomb JB. Systolic Blood Pressure Analysis and Heart Rate Variability. Oral Presentation, American College of Surgeons (ACS), 91st Annual Clinical Congress, San Francisco, CA, 17 October 2005. Holcomb JB. Research Issues Related to Combat Casualty Care. Oral Presentation, American Philosophical Society Autumn General Meeting, Philadelphia, PA, 11 November 2005. Holcomb JB. Human Effects of Explosives. Oral Presentation, Blast Injury Conference, Tampa, FL, 15 December 2005.

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NATIONAL (CONTINUED): Holcomb JB. Current Status and Challenges of Combat Pain Management. Oral Presentation. TTCP Combat Main Management: Future Direction and Collaboration, Advanced Technology Applications for Combat Casualty Care (ATACCC), St. Pete Beach, FL, 13 August 2006. Holcomb JB. Damage Control Resuscitation In Iraq. Oral Presentation. Advanced Technology Applications for Combat Casualty Care (ATACCC), St. Pete Beach, FL, 14 August 2006. Holcomb JB. Casualty Care: Joint Theater Trauma System (JTTS): OIF Wounding Patterns and Statistics Research. Oral Presentation, 2006 TO&E Medical Leaders Conference, Atlanta, GA, 28 August 2006. Holcomb JB. Combat Casualty Care: The Deadly Triad of Trauma. Oral Presentation. 2006 TO&E Medical Leaders Conference, Atlanta, GA, 28 August 2006. Holcomb JB. To Cut or Not to Cut? Severe Leg Trauma. Oral Presentation. American College of Surgeons, 92nd Annual Clinical Congress, Chicago, IL, 9 October 2006. Holcomb JB. Hemostatic Resuscitation. Oral Presentation, American College of Surgeons, 92nd Annual Clinical Congress, Chicago, IL, 12 October 2006. Holcomb JB. Application of HemCon in Battlefield Extremity Trauma. Oral Presentation, American Academy of Orthopaedic Surgeons, Extremity War Injuries II: Development of Clinical Treatment Principles, Washington, D.C., 24 January 2007. Holcomb JB. Conducting Research in the Iraq Theater of Operation: Challenges and Possibilities. Oral Presentation, State of the MHS – 2007 Annual Conference, Washington, D.C., 29 January 2007. Holcomb JB. Damage Control – Clinical Outcomes and Research Directions. Oral Presentation, American Association for the Surgery of Trauma – Military Collaboration, Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD, 20 March 2007. Holcomb JB. A National Trauma Institute (NTI). Oral Presentation, National Injury and Shock Institute, Shock Conference, Baltimore, MD, 9 June 2007. Holcomb JB. The Need for New Monitors. Oral Presentation, Vital Sign Monitoring for ERCS Symposium, St. Pete Beach, FL, 12 August 2007. Holcomb JB. Results of Clinical Trials From the War in Iraq and Afghanistan. Oral Presentation. Advanced Technology Application for Combat Casualty Care (ATACCC) Conference, St. Pete Beach, FL, 13 August 2007. Holcomb JB. Selective Non-Operative Management of Penetrating Abdominal Injury from Combat Fragmentation Wounds. Oral Presentation, Advanced Technology Application for Combat Casualty Care (ATACCC) Conference, St. Pete Beach, FL, 13 August 2007. Holcomb JB. Massive Blood Transfusion. Oral Presentation, NCABB 35th Annual Meeting, Durham, NC, 10 September 2007. 52

Holcomb, J.B. CV March 2013

NATIONAL (CONTINUED): Holcomb JB. Moderator for Military Session/Trauma Management. American Association for the Surgery of Trauma (AAST) Annual Meeting, Las Vegas, NV, 28 September 2007. Holcomb JB. What’s New – Military Session. Oral Presentation, American Association for the Surgery of Trauma (AAST) Annual Meeting, Las Vegas, NV, 28 September 2007. Holcomb JB. Back to the Future: Whole Blood. Oral Presentation, AABB Annual Meeting & TSPO 2007, Anaheim, CA, 23 October 2007. Holcomb JB. Novel Approaches to Field Resuscitation of Trauma Session: Trauma Lessons from Iraq. Oral Presentation, American Heart Association Committee for the Resuscitation Science Symposium (ReSS), Orlando, FL, 3 November 2007. Holcomb JB. Traumatic Injury: Implications and Therapy for Hemostasis. Oral Presentation, Bleeding and Therapeutic Approaches in 2008, New Therapies and New Paradigms Meeting, Atlanta, GA, 6 December 2007. Holcomb JB. Department of Defense Heathcare Funding: Priorities & Criteria. Panelist, ABA National Leadership Conference, Washington, D.C., 29 January 2008. Holcomb JB. Overview of Explosion Physics. Oral Presentation, TBI and PH Plenary Session, 2008 Medical Health System Conference, Washington, D.C., 30 January 2008. Holcomb JB. Surgical Innovations – Saving Lives in OEF/IEF. Oral Presentation, 2008 Medical Health System Conference, Washington, D.C., 30 January 2008. Holcomb JB. Orthopedic War Injuries: Lessons for the Trauma Surgeon. Moderator, Military Session, 2008 Eastern Association for the Surgery of Trauma, Jacksonville, FL, 16 January 2008. Gonzalez EA, Jastrow K, Holcomb JB, Kao LS, Moore FA, Kozar RA. Early Achievement of a 1:2 Ratio of FFP:PRBC. Oral Presentation, Western Trauma Association, Squaw Valley, CA, 26 February 2008. Holcomb JB, Jurkovich GJ. Point: Counterpoint I. Oral Presentation, Western Trauma Association, Squaw Valley, CA, 27 February 2008. Holcomb JB. End Point Initiative Meeting. Meeting Chair, National Trauma Institute, Dallas, TX, 19 February 2008. Holcomb JB. Update Damage Control Resuscitation. Oral Presentation, Damage Control: Bringing Home the Lessons of War, 2nd Collaborative Meeting of the AAST, Bethesda, MD, 12 March 2008. Holcomb JB. Update on Interventions for Achieving Operative Hemostasis: A Case-Based Approach. Oral Presentation, Cardiovascular and Metabolic Health Foundation and The Postgraduate Institute for Medicine Symposium, Las Vegas, NV, 25 March 2008. Holcomb JB. Increased Plasma and Platelet to RBC Ratios Improves Outcome in 466 Massively Transfused Civilian Trauma Patients. Oral Presentation, American Surgical Association 128th Annual Meeting, New York City, NY, 25 April 2008. 53

Holcomb, J.B. CV March 2013

NATIONAL (CONTINUED): Holcomb JB. The Wounded Soldier: Advances In Injury Care; Translating the Military Medical Experience to the Civilian Sector. Oral Presentation, Center of Disease Control (CDC), Atlanta, GA, 29 May 2008. Holcomb JB. Trauma Advances in the Long War. Oral Presentation, AUSA Medical Symposium, Henry B Gonzalez Convention Center, San Antonio, TX, 10 June 2008. Holcomb JB. Increased Platelet:RBC Ratios are Associated with Improved Survival after Massive Transfusions. Western Trauma Association, February, 2009. Holcomb JB. Lessons Learned from the Current Battlefield Minimizing Iatrogenic Resuscitation. Keynote Speaker, Annual Trauma Symposium, South Bend, IN, March, 2009. Holcomb JB. Cancio, Lee. Medical Trauma Perspectives on Automation. Automation and Decision Support System Meeting. San Antonio, TX, 4 June 4 2009. Holcomb JB. Cause and Time to Death with Various Plasma: RBC Ratios in a Multi-Center Massive Transfusion Database. Shock Society Resuscitation Meeting. San Antonio, TX, 5 June 2009. Holcomb JB. Increased Plasma and platelet to RBC ratios improves outcome in 466 massively transfused civilian trauma patients. Shock Society Resuscitation Meeting. San Antonio, TX, 5 June 2009. Holcomb JB. 1:1 FFP:RBC is Optimal in Trauma Resuscitation Con. National Trauma Institute, San Antonio, TX, 31 August 2009. Holcomb JB. Military to Civilian Translation: The PROMMTT Resuscitation Trial. American College of Surgeons Clinical Congress. Chicago, IL, 14 October 2009. Holcomb JB. Lessons Learned from the War in Iraq. Uniformed Services University of the Health Sciences. St. Louis, MO, 18 November 2009. Holcomb JB. Massive Transfusion Protocols. Medical Advisory Council, American Red Cross. Washington, D.C., 16 December 2009. Holcomb JB. The Military Experience with Whole Blood Administration. Society of Critical Care Medicine. Miami, FL, 13 January 2010. Holcomb JB. Lessons Learned from the War. Trauma Symposium. Phoenix, AZ, 8 February 2010. Holcomb JB. Damage Control, 1:1:1 Hemostatic Resuscitation: A Proved Concept? American College of Surgeons. Telluride, CO, 3 March 2010. Holcomb JB. Damage control (1:1:1) Haemostatic Resuscitation: A Proved Concept? Western Trauma Association, March 2010 Holcomb JB. Clinical Research-Overview. Trans Agency Coagulopathy in Trauma Workshop. Bethesda, MD, April 2010. 54

Holcomb, J.B. CV March 2013

NATIONAL (CONTINUED): Holcomb JB. Rationale for Pre-Emptive Blood Components. SHOCK Society Meeting, Portland, Oregon, June 2010. Holcomb JB. Trauma Resuscitation: Transitioning Lessons Learned from the Military to Civilians. Institute of Medicine of the National Academies, Washington, DC, 24 June 2010. Holcomb JB. Initial report from PROMMTT: Dod Sponsored Prospective, Observations Multi-Center Massive Transfusion Study. ATACCC, St Petersburg, Florida, 17 August 2010. Holcomb JB. Clinical Outcome Measures. Society for Complexity in Acute Illness Meeting, Atlanta, Georgia, 10 September 2010. Holcomb JB. The Role and Timing on Plasma And Platelet Transfusion in Patients with Acute Hemorrhage. American College of Surgeon National Meeting, Washington, DC, 4 October 2010. Holcomb JB. The Role of FFP in Improving Outcomes After Trauma. American Society of Anesthesiologist’s Annual Meeting, San Diego, CA, 19 October 2010. Holcomb JB. Transfusion Support for Trauma Services. American Society of Hematology Annual Meeting, Orlando, FL, 4-5 December 2010. Holcomb JB. Amputation Rates in OEF. Committee on Tactical Combat Casualty Care (CoTCCC), Tampa, FL, 8 February 2011. Holcomb JB. Wireless Vital Signs Montior: The Texas Prehospital Study. Advanced Technology Applications for Combat Casualty Care (ATACCC), Ft. Lauderdale, FL, 15 August 2011. Holcomb JB. Massive Transfusion. National Institutes of Health Annual Transfusion Medicine Conference, Rockville, MD, 15 September 2011. Holcomb JB. Blood Transfusion. American College of Surgeons Clinical Congress, San Francisco, CA, 24 October 2011. Holcomb JB. Trauma Combat Casualty Care: From the Battlefield to the Streets. Society of Critical Care Medicine, Houston, TX, 6 February 2012. Holcomb JB. Admission Rapid Thrombelastography (r-TEG) Can Replace Conventional Coagulation Tests in the Emergency Department: Experience with 1974 Consecutive Trauma Patients, American Surgical Association, San Francisco, CA, 26 April 2012. Holcomb JB. Damage Control Resuscitation. American Association of the Surgery of Trauma Grand Rounds, Houston, TX, 16 May 2012. Holcomb JB. Acquired Coagulopathy in the Non-Trauma/Trauma Settings. Blood Center CME Faculty Presentation Webcast, Houston, TX, 18 September 2012.

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NATIONAL (CONTINUED): Holcomb JB. Military Service vs. Work in the Civilian Community. American College of Surgeons Clinical Congress, Chicago, IL, 30 September – 3 October 2012. Holcomb JB. Best Practices for Use with Plasma. HHS, BARDA, and NHLBI Blood Products and Cellular Therapies, A Symposium on Emergency Preparedness, Bethesda, MD, 15 November – 16 November, 2012. Holcomb JB. Damage Control Resuscitation Today: A New Paradigm. AABB Audioconference, 1:1:1 Ratio of Massive Transfusion, Houston, TX, 12 December 2012.

REGIONAL: Holcomb JB. Management of Mass Casualties. Emergency Department Grand Rounds, R.E. Thomason Hospital, El Paso, TX, October, 1995. Quetell G, Holcomb JB. Laparoscopic Interval Appendectomy. Southern Medical Meeting, Kansas City, MO, November, 1995. Thomas D, Hetz S, Holcomb JB. Economic and Safety Considerations of Reusable Non-shielded versus Disposable Safety Shielded Trocars. Presented at the Southern Medical Association, Baltimore, MD, November, 1996. Casto J, Holcomb JB. Stage I and II Breast Cancer: A 5-Year Retrospective Treatment Evaluation at William Beaumont Army Medical Center. Presented at the Southern Medical Association, Baltimore, MD, November, 1996. Tonkinson B, Holcomb JB. Cost Analysis: Laparoscopic Nissen Fundoplication Versus Omeprazole. Presented at the Southern Medical Association, Baltimore, MD, November, 1996. Holcomb JB. Combat Surgery in Somalia, 1993. Surgery Grand Rounds, University of Maryland Shock Trauma Center. 17 April 1998. Holcomb JB. New Techniques for Improved Hemorrhage Control. Surgery Grand Rounds, Ryder Trauma Center, Miami FL, 27 April 2000. Holcomb JB. New Techniques for Improved Hemorrhage Control. Surgery Grand Rounds, University of Missouri-Kansas City, Kansas City, Missouri, 6-8 July 2000. Holcomb JB. U.S. Central Command Central Region Medical Symposium 2000. Military Team Training at Ben Taub General Hospital. Tampa, FL, 9 August 2000. Holcomb JB. Trauma Lessons Learned from the Battlefield. Pre-Deployment Lecture to the 274th Forward Surgery Team. Ft. Bragg, NC, 13-14 October 2001. Holcomb JB. Trauma Lessons Learned from the Battlefield. Pre-Deployment Lecture to the 86th Combat Support Hospital. Ft. Campbell, KY, 8-9 November 2001. 56

Holcomb, J.B. CV March 2013

REGIONAL (CONTINUED): Holcomb JB. Improved Hemostasis in Trauma Patients. Trauma Grand Rounds at the Oregon Health & Science University, Portland, OR, 16-17 November 2003. Holcomb JB. Novel Hemostatic Agents and Surgical Combat Casualty Care. Oral Presentation at the Throckmorton Surgical Society Surgical Symposium on Trauma, Des Moines, IA, 16-17 April 2004. Holcomb JB. Bench to Battlefield: Use of rFVIIa. Oral Presentation at the Department of Surgery Grand Rounds, Madigan Army Medical Center, Tacoma, WA, 22-24 September 2004. Holcomb JB. Current Perspective on Combat Casualty Care. Oral Presentation, Grand Rounds, University of Pittsburgh, Pittsburgh, PA, 20 April 2005. Holcomb JB. Induced Hypothermia – Is It Cool to Chill?? Oral Presentation, 12th Annual University of Southern California Trauma/Critical Care Symposium, Pasadena, CA, 23 May 2005. Holcomb JB. The Army Experience in Iraq. Oral Presentation, 12th Annual University of Southern California Trauma/Critical Care Symposium, Pasadena, CA, 23 May 2005. Holcomb JB. Heart Rate Variability in Trauma Patients. Oral Presentation, Surgical Biology Club III Scientific Meeting, San Francisco, CA, 16 October 2005. Holcomb JB. Combat Casualty Care, Oral Presentation. Visiting Professor, Uniformed Services University of Health Sciences, Bethesda, MD, 23 February 2006. Holcomb JB. Damage Control Resuscitation. Oral Presentation, Grand Rounds, University of Tennessee, Chattanooga, TN, 18 October 2006. Holcomb JB. Complex Pulmonary Injuries. Oral Presentation, Critical Care and Trauma Symposium, Harvard Medical School, Boston, MA, 6 November 2006. Holcomb JB. The Joint Theater Trauma System, Trauma Surgery Research and their DOTMLGP Implications. Oral Presentation, Officer Professional Development, Command and General Staff College, Fort Leavenworth, KS, 21 November 2006. Holcomb JB. When and How to use Damage Control Resuscitation. Oral Presentation, Grand Rounds, University of Wake Forest, Winston-Salem, NC, 11 April 2007. Holcomb JB. Damage Control Resuscitation: Directly Addressing the Early Coagulopathy of Trauma. Oral Presentation, 2007 Ohio Chapter Annual Meeting, American College of Surgeons, Columbus, Ohio, 12 May 2007. Holcomb JB. Damage Control Resuscitation. Oral Presentation, Atlanta Surgical Association, Atlanta, GA, 17 May 2007.

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REGIONAL (CONTINUED): Holcomb JB. Damage Control From a Resuscitation Point of View. Oral Presentation, Grand Rounds, University of Arkansas Medical School, Little Rock, AR, 10 July 2007. Holcomb JB. Causalities of War. Oral Presentation, The New Yorker Festival, New York City, NY, 6 October 2007. Holcomb JB. Damage Control Resuscitation. Oral Presentation, Kentucky Statewide Trauma Symposium, Louisville, KY, 30 November 2007. Holcomb JB. Soldier Medicine. Oral Presentation, Grand Rounds. Beth Israel Deaconess Medical Center, Department of General Surgery, Boston, MA, 19 December 2007. Holcomb JB. Seminar on Soldier Medicine. Oral Presentation, Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, MA, 19 December 2007. Holcomb JB. Lessons from Five Years of War, Taking it to the Front Lines: Damage Control at War, War Surgeon: The Steep Learning Curves. Oral Presentation, San Diego Day of Trauma, November, 2008. Holcomb JB. Lessons Learned from Iraq Conflict, New Concepts in Transfusion Therapy in the Critically Injured Patient. Oral Presentation, Detroit Trauma Symposium, November, 2008. Holcomb JB. Oral Presentation, Grand Rounds, Seattle Washington, November, 2008. Holcomb JB. On the Front Line: Lessons Learned. Keynote Speech, South Bend Trauma Symposium, March 2009 Holcomb JB. Mitigating Iatrogenic Resuscitation Injury. Grand Rounds, Oregon Health and Science University, March, 2009. Holcomb JB. Adding Plasma to Red Cells. Portland Oregon Surgical Society, March, 2009. Holcomb JB. Damage Control Resuscitation. Annual Research Day Speaker, University of Western Ontario, May, 2010. Holcomb JB. Damage Control Resuscitation: Avoiding Iatrogenic Resuscitation Injury. Grand Rounds, University of Minnesota, May, 2010. Holcomb JB. Coagulation and Inflammatory Effects of Plasma. ICU Presentation, University of Minnesota, May 2010. Holcomb JB. Mandatory Colostomy to Combat Colon Injuries. 2nd Annual Austin Trauma and Critical Care Conference, Austin, TX, June 2010. Holcomb JB. Transfusion Practices: Lessons Learned from Combat. 2nd Annual Austin Trauma and Critical Care Conference, Austin, TX, June 2010.

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REGIONAL (CONTINUED): Holcomb JB. Wireless Vital Sign Monitoring. 2nd Annual Austin Trauma and Critical Care Conference, Austin, TX, June 2010. Holcomb JB. Blood Transfusion for the 21st Century. Oregon/Washington ACS Chapter Meeting, Sunriver, Oregon, June 2010. Holcomb JB. Prehospital Care. Medic One Prehospital Trauma Symposium, Keynote Speaker, University of Washington, Seattle, WA, 31 January 2011. Holcomb JB. Surgical Life, Arkansas Alpha Chapter of Alpha Omega Alpha Banquet, Keynote Speaker, University of Arkansas for Medical Sciences, College of Medicine, Little Rock, AR, 25 April 2011. Holcomb JB. Damage Control Resuscitation, Department of Surgery Grand Rounds, University of Arkansas for Medical Sciences, College of Medicine, Little Rock, AR, 26 April 2011. Holcomb JB. Damage Control Resuscitation, 13th Annual University of Texas Southwestern, Department of Surgery, Surgical Research Forum, Dallas, TX, 17-18 May 2011. Holcomb JB. Damage Control Resuscitation and Trauma Informatics, Annual Meeting of the Georgia Surgical Society, Greensboro, GA, 15-18 September 2011. Holcomb JB. Changes in Resuscitation Philosophy in Rapidly Bleeding Trauma Patients. 3rd Annual Southwest Trauma and Acute Care Symposium, Scottsdale, AZ, 3-4 November 2011 Holcomb JB. Hypovolemia Damage Control Resuscitation. 5th Annual Brazos Valley Regional Advisory Council Trauma and Critical Care Symposium, Bryan/College Station, TX, 18 February 2012. Holcomb JB. Damage Control Resuscitation. Critical Care Grand Rounds & Surgery Grand Rounds, University of Alabama at Birmingham, Birmingham, AB, 19 April 2012. Holcomb JB. Damage Control Resuscitation, Trauma Informatics, Tourniquets, Prehospital Resuscitation, and TEG in Trauma Patients. Hawaiian Islands Trauma Symposium. Waikiki, HI, 5-10 July 2012.

LOCAL: Holcomb JB. New Techniques for Improved Hemorrhage Control. Surgery Grand Rounds, Baylor College of Medicine, Houston, TX, 4 December 1999. Holcomb JB. New Techniques for Improved Hemorrhage Control. Surgery Grand Rounds, UT-Houston, TX, 16 October 2001. Holcomb JB. Combat Casualty Care in Iraq. Oral Presentation, Grand Rounds, University of Texas Health Science-Houston, Houston, TX, 15 December 2004. Holcomb JB. Heart Rate Variability. Oral Presentation. Grand Rounds, University of Texas – Houston Medical School, Houston, TX, 19 January 2006. 59

Holcomb, J.B. CV March 2013

LOCAL (CONTINUED): Holcomb JB. Current Combat Casualty Care, Oral Presentation. Grand Rounds, University of Texas-Houston Health Science Center, Houston, TX, 9 February 2006. Holcomb JB. Minimizing Iatrogenic Resuscitation injury. Grand Rounds, University of Texas. November, 2008. Holcomb JB. Improving Extremity Hemorrhage Control: Civilian Applications of Combat Products. Katy Emergency Medical Services, December, 2009. Holcomb JB. Improving Extremity Hemorrhage Control: Civilian Applications of Combat Products. Brazoria County EMS, March, 2009. Holcomb JB. Lessons Learned from the War. University of Texas Medical School, Orthopedic Grand Rounds. Houston, TX, February 2010. Holcomb JB. Understanding the Current Principles Regarding Resuscitation and Blood Component Replacement in the Management of Acute Hemorrhage. OBGYN Lecture, University of Texas – Houston Medical School, Houston, TX, 16 March 2010. Holcomb JB and Deborah Del Junco. The Epidemiology and Control of Traumatic Injury: A Global Health Priority. Issues in Global Health Lecture Series, University of Texas-Houston Health Science Center, Houston, TX, 12 April 2010. Holcomb JB. Blackhawk Down Scenario. Housestaff Association Meeting, Houston, TX, 14 April 2010. Holcomb JB. Damage Control Resuscitation. Department of Emergency Medicine Resident Lecture, University of Texas Medical School at Houston, Houston, TX, 12 October 2011. Holcomb JB. Change in Resuscitation Philosophy. Department of Surgery Grand Rounds, University of Texas Medical School at Houston, Houston, TX, 10 November 2011. Holcomb JB. Transfusion, Tourniquets and Trauma Informatics. Life Flight/Lake Jackson Trauma Symposium, Lake Jackson, TX, 28 March 2012. Holcomb JB. Damage Control Resuscitation. Citywide Hematology Grand Rounds, The Methodist Hospital, Houston, TX, 16 May 2012. Holcomb JB. Damage Control Resuscitation. Bill T. Teague Lectureship, Gulf Coast Regional Blood Center, Houston, TX, 17 May 2012. Holcomb JB. Trauma Informatics. Scottsdale Institute’s Fall Forum hosted by Memorial Hermann, Houston, TX, 26 October 2012. Holcomb JB. The Next Evolution of Damage Control Surgery. Methodist Grand Rounds, Houston, TX, 7 November 2012. 60

Holcomb, J.B. CV March 2013

LOCAL (CONTINUED): Holcomb JB. The Next Evolution of Damage Control Surgery. University of Texas Medical School at Houston, Houston, TX, 8 November 2012.

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