JOURNAL TRANSCRIPT

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San Francisco Radiation Oncology Conference Saturday, July 7, 2007 All Sessions in Golden Gate A & B Welcome John Meyer 8:00am - 9:45am I. A New Era of Practice in Radiation Oncology Introduction C. Norman Coleman National Institutes of Health • Radiation Oncology in the New World of Cancer Biotechnology C. Clifton Ling Memorial Sloan-Kettering Cancer Center • New Biophysical Tools/New Treatment Goals in the Targeting of Radiotherapy Paul Harari University of Wisconsin • New Mechanisms, New Opportunities in Radiation/Drug Interaction Discussion: Drs. Coleman, Ling and Harari 10:15am - 11:15am Panel 1: Gastro-Intestinal Cancers Christopher Willett, Chair Howard Safran Brown University • New Bio-Molecular Therapies of GastroIntestinal Cancers

11:15am - 12:00pm The Buschke Lecture Harry Bartelink The Netherlands Cancer Institute • The Evolving World of Breast Cancer Radiotherapy: Key Advances through Critical Investigation 1:00pm - 2:45pm II. New Radiotherapy Approaches and Treatment Protocols Panel 2: Genito-Urinary Cancers Mack Roach, Chair Alan Pollack Fox Chase Cancer Center • Molecular Markers Identified for Prostate Cancer Therapy Mack Roach University of California, San Francisco • New Directions in the Radiotherapy of Prostate Cancer Howard Sandler University of Michigan • New Perspectives on the Chemotherapy of Prostate Cancer Discussion: Drs. Pollack, Roach and Sandler

Christopher Willett Duke University • Treatment Advances in the Radiotherapy of GI Cancer Discussion: Drs. Safran and Willett 15

3:15pm - 4:15pm Panel 3: Thoracic Cancers Laurie Gaspar, Chair

• A New Biology and a New Cancer

Karen Kelly University of Kansas • Novel, Molecularly-Targeted Therapies for Lung Cancer

4:15pm - 5:00pm The Vaeth Lecture

Therapeutics for Lung Cancer Treatment

Discussion: Drs. Kelly and Gaspar

Laurie Gaspar University of Colorado

Jens Overgaard Aarhus University Hospital, Denmark • Defining New Directions for the Radiotherapy of Cancer

Sunday, July 8, 2007 8:00am - 10:00am III. Joint session with ICRR Salon 9 Yerba Buena William Dewey University of California, San Francisco • How Cells Die After Irradiation Jay Loeffler Massachusetts General Hospital Cancer Center • Protons and Other Charged Particles: What Is the Potential Impact on Radiotherapy Practice? Eric Hall Columbia University • Second Cancers after Radiotherapy – An Increasing or Decreasing Concern? 10:30am - 12:00pm Panel 4: Hypofractionation and Dose Escalation Salon 7 Yerba Buena Herman Suit, Chair Robert Timmerman Southwestern University 16

• Stereotactic Body Radiotherapy: New Results of High Fraction Radiotherapy Julian Rosenman University of North Carolina • Hypofractionation, Dose Heterogeneity and Dose Escalation Programs with IMRT: How Far Have We Gone, How Far Can We Go? Herman Suit Massachusetts General Hospital Cancer Center • Hypofractionation, Dose Heterogeneity, Mega-Dose SBRT: A New Radiobiology? Discussion: Drs. Timmerman, Rosenman, and Suit, joined by Dr. E. Hall 1:00pm - 3:00pm IV. New Radiotherapy Approaches & Treatment Protocols Panel 5: Head and Neck Cancers Salon 7 Yerba Buena Kian Ang, Chair

David Brizel University of North Carolina • Combination of Radiotherapy with Chemotherapy: Promises and Pitfalls Vincent Gregoire UCL University St. Luc, Belgium • IMRT: Current and Future Roles in the Treatment of Head/Neck Cancers Lei Dong MD Anderson Cancer Center • Practical Advances in the Treatment Planning & Delivery of Head/Neck Cancer Therapy

3:15pm - 4:00pm The D’Angio Lecture (with ICRR). Salon 9 Yerba Buena Daniel Von Hoff University of Arizona • New Cancer Therapeutics 4:00pm - 4:45pm Lymphomas Salon 7 Yerba Buena Roger Macklis Cleveland Clinic Foundation • New Treatment Programs in the Radiotherapy of Lymphomas

Lester Peters Peter MacCallum Cancer Centre • New Perspectives in the Radiotherapy of Head/Neck Cancer Kian Ang MD Anderson Cancer Center • Evolving Treatment Programs in the Radiotherapy of Head/Neck Cancer Discussion: Drs. Brizel, Gregoire, Dong, Peters and Ang

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13th International Congress of Radiation Research 8:00am - 10:15am Joint Session with SFRO Conference Topical Reviews Session 1 Salon 9 Yerba Buena TR 1: How cells die after radiation William Dewey, University of California, San Francisco, USA TR 2: Protons and other charged particles: what is the potential impact on radiotherapy practice? Jay Loeffler, Massachusetts General Hospital, Boston, USA TR 3: Second cancers after radiotherapy: an increasing or decreasing concern? Eric Hall, Columbia University, New York, USA _______________________________________ 10:45am - 12:15pm Topical Reviews Session 2 Salon 8 Yerba Buena TR 4: What physics can teach us about radiation biology Dudley Goodhead, Medical Research Council, Oxford, UK TR 5: Molecular signatures of radiation response Sally Amundson, Columbia University, New York, USA _______________________________________

1:30pm - 3:00pm Topical Reviews Session 3 Salon 8 Yerba Buena TR 6: Molecular signatures of cancer Gavin Sherlock, Stanford University, Stanford, USA TR 7: What can mouse models teach us in cancer research? Laura Attardi, Stanford University, Stanford, USA _______________________________________ 3:15pm - 4:00pm Plenary Lecture Salon 9 Yerba Buena PL 1: D’Angio Lecture: New cancer therapeutics Dan von Hoff, University of Arizona, Tucson, USA _______________________________________ 4:00pm - 5:20pm Topical Reviews Session 4 Salon 8 Yerba Buena TR 8: The importance of epigenetics in cancer Randy Jirtle, Duke University, Durham, USA TR 9: Radiation biology teaching - current status and future prospects Elaine Zeman, University of North Carolina, Chapel Hill, USA _______________________________________ 6:00pm - Opening Ceremony Salon 9 Yerba Buena 7:30pm - Welcome Reception Golden Gate A&B

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Sunday

Sunday, July 8, 2007

Monday, July 9, 2007 8:30am - 9:30am Congress Lectures

EO 1: Development of imaging probes and markers for biological characterization of tumors Salon 7, Yerba Buena Juri Gelovani, The University of Texas, MD Anderson Cancer Center, Houston, USA Chair: Gloria C. Li, Memorial SloanKettering Cancer Center, New York, USA ______________________________________

CL 1: Molecular imaging as applied to cancer and radiation therapy Salon 7, Yerba Buena Patricia Price, University of Manchester Christie Hospital, Manchester, UK Chair: A. J. van der Kogel, University of Nijmegen, Nijmegen, The Netherlands ______________________________________

EO 2: Effects of track structure in radiation chemistry Salon 15, Yerba Buena Jay LaVerne, University of Notre Dame, South Bend, USA Chair: Hooshang Nikjoo, NASA Johnson Space Center, Houston, USA ______________________________________ EO 3: Reassessment of effective dose of a-bomb radiation and its possible impact on risk evaluation Salons 1, 2, 3 Yerba Buena Masao Sasaki, Kyoto University, Kyoto, Japan Chair: Eric Hall, Columbia University, New York, USA ______________________________________ EO 4: DNA repair foci: what are they and what are they good for? Salon 8, Yerba Buena Peggy Olive, BC Cancer Research Centre, Vancouver, Canada Chair: Raymond Meyn, University of Texas MD Anderson Cancer Center, Houston, USA ______________________________________

CL 2: Low energy electron driven processes and their radiation chemical effects Salon 15, Yerba Buena Leon Sanche, University of Sherbrooke, Canada Chair: Michael Sevilla, Oakland University, Rochester, USA ______________________________________ CL 3: WHO REMPAN, international network for public health and medical preparedness and assistance in radio-nuclear emergencies Salons 1, 2, 3 Yerba Buena Zhanat Carr, WHO, Geneva, Switzerland Chair: Nelson Chao, Duke University, Durham, USA ______________________________________

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Monday

7:30am - 8:15am Eye Openers

CL 4: Role of phosphorylation in non homologous end joining Salons 4, 5, 6 Yerba Buena Susan Lees Miller, Southern Alberta Cancer Research Centre, Calgary, Canada Chair: Melanie Spotheim-Maurizot, Centre National de la Recherche Scientifique, Orleans, France ______________________________________

CL 6: Second cancers following radiation treatment for childhood cancer Salons 10, 11 Yerba Buena Ann Mertens, University of Minnesota, Minneapolis, USA Chair: Marilyn Stovall, University of Texas MD Anderson Cancer Center, Houston, USA ______________________________________ 10:00am - 12:00pm Symposia Imaging for Radiation Therapy and Cancer Biology Salon 7, Yerba Buena Chair: John Kurhanewicz, University of California, San Francisco, San Francisco, USA S 1:

10:00 - Tumor imaging with immunohistochemistry A. J. van der Kogel, University of Nijmegen, Nijmegen, Netherlands 20

11:00 - Multiparametric magnetic resonance imaging of prostate cancer patients receiving radiation therapy John Kurhanewicz, University of California, San Francisco, San Francisco, USA 11:30 - Imaging the tumor microenvironment in radiation therapy Zaver Bhujwalla, Johns Hopkins University, Baltimore, USA ______________________________________ Track Structure Physics and Chemistry Salon 15, Yerba Buena Chairs: Simon M. Pimblott, University of Manchester, Manchester, UK Gisela Taucher-Scholz, GSI, Darmstadt, Germany S 2:

10:00 - Stochastic simulation of water radiolysis by swift ions Benoit Gervais, University of Caen, Caen, France 10:30 - Experiment-with-simulation analysis of hydrated electron and hydroxyl radical yields in heavy ion radiolysis of water Simon M. Pimblott, University of Manchester, Manchester, UK

Monday

CL 5: The effect of hypoxia on growth factor signaling and metabolism in tumors Salon 8, Yerba Buena Nicholas Denko, Stanford University, Stanford, USA Chair: Amato Giaccia, Stanford University, Stanford, USA ______________________________________

10:30 - Reporter gene imaging for tumor characterization and radio-gene therapy Gloria C. Li, Memorial Sloan Kettering Cancer Center, New York, USA

11:00 - Induction of DNA damage by heavy ions: lesion clustering and localized cellular response Gisela Taucher-Scholz, GSI, Darmstadt, Germany 11:30 - Ion irradiation damage in structural materials Gary Was, University of Michigan, Ann Arbor, USA ______________________________________

10:00 - Multiple parameter biological dosimetry William F. Blakely, Armed Forces Radiobiology Research Institute, Bethesda, USA 10:30 - Network for cytogenetic biodosimetry in Japan Mitsuaki Yoshida, National Institute of Radiological Science, Chiba, Japan 11:00 - Electron paramagnetic resonance radiation dosimetry Francois Trompier, Institut de Radioprotection et de Sûreté Nucléaire, Clamart, France 11:30 - Triage biological dosimetry using the dicentric assay Ruth Wilkins, Consumer and Clinical Radiation Protection Bureau, Ottawa, Canada

10:00 - DNA polymerase beta: role in repair and survival after ionizing radiation Conchita Vens, Netherlands Cancer Institute, Amsterdam, The Netherlands 10:30 - The roles of MDC1 in response to DNA double strand breaks via regulation RPA: inhibition of replication and promotion of homologous recombination Junran Zhang, Washington University, Saint Louis, USA 11:00 - Maintenance of replication fork progression on damaged and undamaged DNA Eva Petermann, University of Sussex, Brighton, UK 11:30 - Phosphorylation of RPA in replication and repair Kathleen Dixon, University of Arizona, Tucson, USA ______________________________________ Targeting Tumor Hypoxia for Therapeutic Gain Salons 12, 13 Yerba Buena Chairs: Stephanie McKeown, University of Ulster, Coleraine, UK William Wilson, Auckland Cancer Society Research Centre, Auckland, New Zealand S 5:

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Monday

Triage Biological Dosimetry after a Radiological Event Salons 10, 11 Yerba Buena Chairs: Norman Coleman, NCI, National Institutes of Health, Bethesda, USA Narayani Ramakrishnan, NIAID, National Institutes of Health, Bethesda, USA S 3:

Replication Fork Management and Genome Stability: the Role of Single and Double Strand Break Repair Salons 1, 2, 3 Yerba Buena Chair: Simon Powell, Washington University, Saint Louis, USA S 4:

10:00 - Evaluation of the bioreductive activity of AQ4N, from lab to clinic Stephanie McKeown, University of Ulster, Coleraine, UK 10:30 - Development of the novel hypoxiaactivated bifunctional alkylating agent PR-104 William Wilson, Auckland Cancer Society Research Centre, Auckland, New Zealand

11:30 - Imaging and targeting tumor hypoxia by use of the HIF-1 function Shinae Kizaka-Kondoh, Kyoto University, Kyoto, Japan ______________________________________ Chemotherapy Enhanced Radiation Therapy (CERT) Salons 4, 5, 6 Yerba Buena Chairs: Kathy Mason, University of Texas MD Anderson Cancer Center, Houston, USA Lydia Armstrong, Sanofi-Aventis, Great Valley, USA S 6:

10:00 - Preclinical chemoradiotherapy Luka Milas, University of Texas MD Anderson Cancer Center, Houston, USA 10:30 - Clinical trials in Europe Harry Bartelink, Netherlands Cancer Institute, Amsterdam, The Netherlands 22

11:30 - Current status of development of various chemoradiotherapeutic approaches, with reference to industrialized and limited-resource settings Jolyon Hendry, IAEA, Vienna, Austria ______________________________________ 12:00pm - 1:00pm Plenary Lecture Salon 9, Yerba Buena PL 2: Molecular imaging in diagnosis and therapy Hedvig Hricak, Memorial SloanKettering Cancer Center, New York, USA Chair: C. Clifton Ling, Memorial SloanKettering Cancer Center, New York, USA ______________________________________ 2:00pm - 4:00pm Symposia Molecular Image-Guided Radiotherapy Salons 4, 5, 6 Yerba Buena Chair: Vincent G. Gregoire, University of Leuven, Belgium Karin Haustermans, University Hospital Gasthuisberg, Leuven, Belgium

S 7:

Introduction Vincent G. Gregoire, University of Leuven, Belgium

Monday

11:00 - Anti-metastatic opportunities in targeting tumour Kaye Williams, University of Manchester, Manchester, UK

11:00 - US clinical trials and their influence on the standard of care Patricia Eifel, University of Texas MD Anderson Cancer Center, Houston, USA

2:00 - Future PET tracers for IGRT: prospect and caveat Robert H. Mach, Washington University, St. Louis, USA 2:30 - Image registration and segmentation in functional IGRT Thomas Guerrero, University of Texas MD Anderson Cancer Center, Houston, USA

3:30 - Use of fMRI in IGRT: pre-clinical and clinical data Sarah Nelson, University of California, San Francisco, San Francisco, USA ______________________________________ Oxidative Radicals as Signaling Agents Salons 10, 11 Yerba Buena Chairs: Peter Wardman, Gray Cancer Institute, Northwood, UK David Gius, NCI, National Institutes of Health, Bethesda, USA S 8:

2:00 - Intercellular induction of apoptosis: role of reactive oxygen species and low dose radiation

Georg Bauer, University of Freiburg, Freiburg, Germany 2:30 - Induction of apoptotic signaling cascades by aldehyde by-products of lipid peroxidation Diana Averill, University of Québec, Montréal, Canada

3:30 - Intercellular induction of apoptosis-role of reactive oxygen species and radiation David Gius, NCI, National Institutes of Health, Bethesda, USA ______________________________________ Radiation and the human environment Salon 15, Yerba Buena Chairs: Maria Luisa Botelho Soares, University of Porto, Porto, Portugal William Cooper, University of California, Irvine, Irvine, USA S 9:

2:00 - Removing carcinogenic nitrosamines from waters using radicals Stephen Mezyk, California State University, Long Beach, Long Beach, USA 2:30 - Hydroxyl radical’s role in the remediation of a common herbicide, 2, 4dichlorophenoxyacetic acid (2, 4-d) Julie Peller, Indiana University Northwest, Gary, USA 3:00 - Radiation chemistry of water treatment William Cooper, University of California, Irvine, Irvine, USA ______________________________________

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Monday

3:00 - Use of PET for molecular imageguided RT: preclinical and clinical data Karin Haustermans, University Hospital Gasthuisberg, Leuven, Belgium

3:00 - Main route of radiationcarcinogenesis is DNA damageindependent pathway Masami Watanabe, University of Kyoto, Kyoto, Japan

2:00 - The role of IREi-XBP1 on tumor growth: implications for cancer therapy Albert Koong, Stanford University, Stanford, USA

2:00 - Structural aspects of the recognition of oxidized purines by the formamidopyrimidine-DNA glycoslylase, Fpg Bertrand Castaing, Centre National de la Recherche Scientifique, Orleans, France

2:30 - Regulation of protein folding during hypoxia Marianne Koritzinsky, University of Maastricht, Maastricht, The Netherlands

2:30 - Visualizing a replicative polymerase encounter unrepaired free radical DNA lesions Silvie Doublie, University of Vermont, Burlington, USA 3:00 - DNA damage and translesions synthesis Wei Yang, NIDDK, National Institutes of Health, Bethesda, USA 3:30 - RecA/Rad51 assembly on single molecules of DNA Stephen Kowalczykowski, University of California, Davis, Davis, USA ______________________________________ S 11: The Impact of Oncogenes and Translational Control on Tumor Growth Salon 7 Yerba Buena Chairs: Brad Wouters, University of Maastricht, Maastricht, The Netherlands Costas Koumenis, University of Pennsylvania, Philadelphia, USA

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3:00 - Activation of the PERK-elF2alphaATF4 arm of the UPR by hypoxia: its role in tumor development and opportunities for therapeutic intervention Costas Koumenis, University of Pennsylvania, Philadelphia, USA 3:30 - Translational control of angiogenesis in breast cancer Robert Schneider, New York University, New York, USA ______________________________________ S 12: Traditional Chinese Medicine Combined with Conventional Cancer Therapy Salon 14, Yerba Buena Chair: Zhongxing Liao, University of Texas MD Anderson Cancer Center, Houston, US 2:00 - Traditional Chinese medicine for cancer: the road to China Lorenzo Cohen, University of Texas MD Anderson Cancer Center, Houston, USA 2:30 - Combined chemotherapy, radiation therapy and traditional Chinese medicinal treatment for pancreatic cancer Luming Liu, Fudan University, Shanghai, China

Monday

S 10: Protein Structures Meet DNA Damages Salons 1, 2, 3 Yerba Buena Chair: Susan S. Wallace, University of Vermont, Burlington, USA

3:00 - Traditional Chinese medicine in the management of treatment related pneumonitis-rational and evidence Zhongxing Liao, University of Texas MD Anderson Cancer Center, Houston, USA

5:45pm Kaplan Award Lecture (IARR) Salon 9 Yerba Buena The remarkable yin and yang of tumor hypoxia Martin Brown, Stanford University, Stanford, USA Chair: Peggy Olive, BC Cancer Research Centre, Vancouver, Canada ______________________________________

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Monday

3:30 - Integrative medicine for colonrectum cancer Yang Yufei, China Academy of Traditional Chinese Medicine, Beijing, China. ______________________________________

4:00pm - 5:30pm Poster Session 1 ______________________________________

IARR Kaplan Award The Henry S Kaplan Distinguished Scientist Award was established by the International Association for Radiation Research in 1985 and is awarded every four years to honor outstanding contributions to the field of radiation research. Past awardees have been Mort Elkind (1987), Rod Withers (1991), Ged Adams (1995), Jack Little (1999), and Eric Hall (2003). Henry Kaplan was a physician and

cancer treatment in the U.S., was responsible for very significant improvements in the treatment by radiation of Hodgkins and non-Hodgkins lymphoma and made major contributions to understanding the viral etiology of cancer. He was a member of the National Academy of Sciences and Presidents of the American Association for Cancer Research (196667), the International Association for Radiation Research (1974-79) and the Radiation Research Society (1956-57). Professor J. Martin Brown, this year’s awardee, is a professor in the Division of Radiation and Cancer Biology at Stanford University School of Medicine. He is honored for his pioneering work in the field of tumor hypoxia particularly for emphasizing the possibility of exploiting tumor hypoxia, and for the development of the hypoxia activated cytotoxin tirapazamine, currently in advanced clinical trials. He received his undergraduate degree in physics from Birmingham University in England and his Ph.D. in Cancer Biology from Oxford University. He is a former president of the Radiation Research Society and former chair of the NIH Radiation Study Section. Prof. Brown has published more than 260 peerreviewed articles and has received a number of awards in recognition of his work including the 1999 Bruce Cain Memorial Award from the American Association for Cancer Research, the 1999 Gold Medal from the American Association for Therapeutic Radiology and Oncology, the Failla Award from the Radiation Research Society and the Weiss Medal from the Association for Radiation Research. He is currently the Senior Editor for Biology for the International Journal of Radiation Oncology, Biology and Physics. 26

Monday

scientist of enormous stature who pioneered the development of the linear accelerator for

Poster Session 1 PS1.1 - Biodosimetry 1 PS1001 - Neurobiological risks due to tritiated water exposure accessed against bulk tritium release from nuclear industry Narendra Jain, Arvind Bhatia.

PS1003 - The experience of FISH technique application for reconstruction of individual radiation doses in Chernobyl liquidators Sergey S. Dybskiy, Maria A. Pilinskaya. PS1004 - Estimation of RBE values for carbon beams at high dose region using multicellular spheroids of HMV-I cells Yoshitaka Matsumoto, Daisuke Shimao, Mizuho Aoki, Ryoichi Hirayama, Nobuo Kubota, Koichi Ando, Hirohiko Tsujii, Yoshiya Furusawa. PS1005 - Biomarkers of radioresistance in cervical cancer cells Richard A. Britten, Angela Johnson, Richard Drake. PS1006 - In-vivo dose verification and beam flattening in radiobiology laboratory

PS1007 - The heamatological effects of radar on human blood Shamsi Shekari, Hamid Samavat. PS1008 - Study of individual responses to combined injuries in non human primate: investigation for relevant neuro-immune biomarkers of prognosis P. Martigne, A. Peinnequin, J. Mathieu, M. Vivier, D. Clarençon. PS1009 - Enhanced yield of chromosome aberrations after CT examinations in paediatric patients Ursula Oestreicher, Guenther Stephan, Linda Walsh, Werner Panzer, Karl Schneider. PS1010 - Radiation dose estimation by tooth enamel ESR dosimetry for Nagasaki atomic bomb survivors Tatsuya Shimasaki, Mariko Mine, Yutaka Okumura, Eihichi Miyamoto, Seiji Okada. PS1011 - Acute and chronic effects of whole body gamma irradiation on heart contractility and coronary flow Tatsiana Suvorava, Klavdiya Bulanova, Leonid Lobanok. PS1012 - The changes of human peripheral blood B cell subpopulations and subsets after in vitro irradiation 27

Monday

PS1002 - Simulation study of sea-level cosmic radiation in a human body phantom and shielding effects Pushpa Wijesinghe, Xiaochun He.

Natalya V. Morrow, Vladimir A. Semenenko, X. Allen Li.

Zuzana Rehakova, Jiri Sinkora, Marcela Vlková, Doris Vokurkova. PS1013 - Early alterations in pulmonary interleukin expression and cellular responses after low dose radiation Jacob N. Finkelstein, Jacqueline P. Williams, Eric Hernady, Christina Reed, Carl Johnston.

PS1015 - Analyisis of dose record and epidemiology for radiation workers in Korea Soo Yong Choi, Hae Won Chung. PS1016 - What consequences of the prolonged irradiation may be? Alexandra P. Kravets. PS1017 - Electron paramagnetic resonance dosimetry investigation for population living in the vicinity of the Semipalatinsk Nuclear Test Site Kassym S. Zhumadilov. PS1018 - Biological evaluation of a dose response in the oral cavity of patients undergoing head and neck radiotherapy Matthew Coleman, Samir Narayan, Joerg Lehman, Kerry Nolan, Andrew T. Vaughan, Claus Yang, James Purdy, Grace Loredo, Srinivasan Vijayakumar. ______________________________________ 28

PS1019 - Radiation-induced, nitric oxidemediated bystander effects contribute to the induction of radioadaptive responses Hideki Matsumoto, Masanori Tomita, Kensuke Otsuka, Takeo Ohnishi. PS1020 - Mitochondria-depended signaling pathway are involved in the early process of radiation induced bystander effects Shaopeng Chen, Lijun Wu, Ye Zhao, Wei Han, Lingyan Zhu, Jun Wang, Linzhi Bao, Erkang Jiang, An Xu, Tom K. Hei, Zengliang Yu. PS1021 - Direct ESR measurement of novel slow-releasing radicals those might be responsible for delayed mutation induction in 4 Gy γirradiated syrian golden hamster embryonic cells Jun Kumagai1, Akira Harada1, Ryuichi Kanamori, Eri Yoshikawa, Masayoshi Miyazaki, Seiji Kodama, Masami Watanabe. PS1022 - The role of DNA double strand breaks repair in radiation induced bystander responses Genro Kashino. PS1023 - Activation of signalling pathways in cells exposed to medium from irradiated cells Fiona Lyng, Orla Howe, Rocky Bo Li, Brendan McClean.

Monday

PS1014 - Radiation injury during postnatal lung development Carl Johnston, Jacqueline P. Williams, Eric Hernady, Jacob N. Finkelstein.

PS1.2 - Bystander Effects 1

PS1024 - Modeling of bystander signaling related to different cellular endpoints Fakir Hatim, Wai Yuan Tan, Werner Hofmann, Rainer Kurt Sachs, Kevin Prise.

PS1026 - Mechanism of radiation induced bystander effects: implication from mitochondrial function Hongning Zhou, Vladimir Ivanov, Yu-Chin Lien, Alan Bigelow, Tom K. Hei. PS1027 - The role of gap-junction communication in the cellular responses to high and low dose gamma-rays Manuela Buonanno, Zhi Yang, Badri N. Pandey, Sonia M. de Toledo, Andrew L. Harris, John B. Little, Edouard I. Azzam. PS1028 - Non-targeted effects of ionising radiation - a new european integrated project, 2006-2010 Sisko Salomaa, Eric G. Wrigh, Guido Hildebrandt, Munira Kadhim, Mark P. Little, Kevin M. Prise, Oleg V. Belyakov. ______________________________________ PS1.3 - Cell Behavior/Stem Cells 1 PS1029 - Atherosclerotic lesion development in gamma-radiation exposed apolipoprotein E-/- mice

PS1030 - Production of cytokines by splenocytes and macrophages after single or fractionated low-level irradiations with X-rays Marek K. Janiak, Aneta Cheda, Ewa M. Nowosielska, Jolanta Wrembel-Wargocka. PS1031 - Morphological and biomolecular changes induced by UV laser irradiation in silkworm, Bombyx mori embryo Hosaholalu B. Manjunatha, Satyanarayanagouda R. Hosagoudar. PS1032 - Hematopoiesis under chronic low dose rate irradiation: Quantitative modeling of blood responses of a large animal model Thomas M. Seed. PS1033 - Differential induction from xirradiated human peripheral blood monocytes to dendritic cells Hironori Yoshino, Kenji Takahashi, Ikuo Kashiwakura. PS1034 - Behavior of primitive hematopoietic stem cells and peripheral blood cytokines in radiation adaptive responses Kensuke Otsuka, Masanori Tomita, Takao Koana, Hiroshi Tauchi. PS1035 - Chromosome aberrations do not persist in the lymphocytes or bone marrow cells of mice irradiated in utero or soon after birth

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Monday

PS1025 - Bystander effects in 3dimensional tissue: a quantitative mechanistic model of spatial patterns Igor Shuryak.

Ron E. Mitchel, Stewart C. Whitman, Heather Wyatt.

Mimako Nakano, Yoshiaki Kodama, Kazuo Ohtaki, Eiji Nakashima, Ohtsura Niwa, Megumi Toyoshima, Nori Nakamura. PS1036 - The depressed Th1-like responsein in irradiated mice is associated with an impairment of the NK cells Hae-Ran Park, Uhee Jung, SungKee Jo.

PS1038 - Highly radiosensitive germ cells in Medaka ric1 mutant with abnormal DNA double-strand break repair and apoptosis induction. Hiroshi Mitani, Kouichi Aizawa, Kanako Yori, Chiharu Kaminaga, Toshikazu Yashita, Kanae Nishino, Masayuki Hidaka, Masato Kinoshita, Shoji Oda. ______________________________________ PS1.4 - Clinical Therapeutic Radiobiology 1 PS1039 - Retrospective study of the influence of anaemia in patients with advanced head and neck cancer received postoperative radiotherapy Sherif A. Abdelwahab, Mohamed M. El-Basiouny, Hatem M. Abdalla, 30

PS1040 - Quantitative analyses of hypoxia and vessels in human tumors Sydney M. Evans, Kevin Jenkins, W. Timothy Jenkins, Cameron J. Koch. PS1041 - Vascular density, hypoxia and tumor-associated macrophages in the irradiated tumors Ji-Hong Hong, Fang-Hsin Chen, Chun-Chieh Wang, Chien-Sheng Tsai, William H. McBride, ChiShiun Chiang. PS1042 - Identification and therapeutic targeting of hypoxia in H&N cancer Lester J. Peters, Danny Rischin, Richard Fisher, June Corry, Rod Hicks. PS1043 - Measuring oxygen levels in human tumors repeatedly to provide information for optimizing therapy Benjamin B. Williams, Marc S. Ernstoff, Bassem Zaki, Alan C. Hartford, Piotr Lesniewski, Harold M. Swartz. PS1044 - PAI-1 (plasminogen activator inhibitor type-1) correlates to hypoxia and radiation resistance in squamous cell carcinomas of the head and neck (SCCHN) Christine M. Bayer, Joerg Hoetzel, Hannes P. Egermann, Michael Molls.

Monday

PS1037 - Alteration of inflammation molecules as function of time after radiation Weimin Sun, Shanmin Yang, Hengshan Zhang, Wei Wang, Mei Zhang, Chaomei Liu, Steven Schwartz, Lurong Zhang, Paul Okunieff.

Hany M. Abdel-Aziz, Maha Maha Margerges, Ali M. Azmy, Branislav Jeremic.

PS1046 - Lymphopoiesis of treated oncological patients is a probable source of individual life span’s variability A. Shutko, L. Ekimova, I Shoumski, N. Chizova, L. Yurkova, T. Bochkareva, V. Mus, M. Karamullin. PS1047 - Diagnostics and therapeutics of 111in-vinorelbine liposomal drug in tumor-bearing animal model T S. Chou, Y Y. Lin, J J. Hwang, H E. Wang, Y L. Tseng, S J. Wang, J Q. Whang-Peng, G Ting. PS1048 - The role of EGFR related proteins in the response to preoperative chemoradiotherapy in combination with cetuximab in patients with rectal cancer Annelies Debucquoy, Jean-Pascal Machiels, Olivier Gevaert, Anneleen Daemen, Sarah Roels, William Mc Bride, Karin Haustermans. PS1049 - Chemotherapy enhanced radiation therapy: U.S. Clinical trials and their influence on the standard of care Patricia J. Eifel.

PS1.5 - DNA Damage 1 PS1050 - Impact of oxygen concentration on yields of complex DNA damages caused by ionizing radiation V. Stepan, M. Davidkova. PS1051 - Analysis of T-cell receptor (TCR) variants and apoptosis induced by beta radiation from tritiated water at low-dose rate in different p53 status mice Toshiyuki Umata, Naoki Kunugita, Ryuji Okazaki, Akira Ootsuyama, Toshiyuki Norimura. PS1052 - Effect of temperature during irradiation on the level of DNA damage in human peripheral blood lymphocytes exposed to X-rays and neutrons Andrzej Wojcik, Kinga Brzozowska, Julian Liniecki, Christian Johannes, Günter Obe, Reinhard Hentschel, Wolfgang Sauerwein, Andrea Wittig, Irena Szumiel, Josselin Morand, Ray Moss. PS1053 - Induction of H2AX phosphorylation and apoptosis with radiation treatment and expression of PCNA protein in radiosensitive wasted mouse Barbara A. Szolc-Kowalska, Kaori Nakamura, Daniel Jakubczak, Akiko Hagiwara, Tatjana Paunesku, Tetsuya Ono, Gayle E. Woloschak. PS1054 - Clustered DNA damage in irradiated human cells: the influence of chromatin organization 31

Monday

PS1045 - TNF-mediated cell-death signaling pathway and extracellular matrix pathway are activated by concurrent use of cisplatin with radiotherapy in sequential biopsy specimens from patients with cervical cancer. Mayumi Iwakawa, Tatsuya Ohno, Kaori Imadome, Miyako Nakawatari, Minako Sakai, Takashi Moritake, Etsuko Nakamura, Tomoaki Tamaki, Shingo katoh, Hirohiko Tsujii, Takashi Imai.

Karin Magnander, Ragnar Hultborn, Kristina Claesson, Kecke Elmroth. PS1055 - Residual γH2AX foci predict response to cisplatin and fractionated irradiation in vitro and in vivo Adriana Banuelos, Judit P. Banath, Susan H. MacPhail, James Byrne, Christina Aquino-Parsons, Peggy L. Olive.

PS1057 - The mutation of ric1 induces delayed repair of DNA double strand breaks, cell death inhibition and early checkpoint release Masayuki Hidaka, Shoji Oda, Yoshikazu Kuwahara, Manabu Fukumoto, Hiroshi Mitani. PS1058 - MCT-1 oncogene downregulates p53 and destabilizes genome structure in the response to DNA double-strand damage Hung-Ju Shih, Chik On Choy, Ravi Kasiappan, Jeffrey R. Sawyer, Chung-Li Shu, Kang-Lin Chu, YiRong Chen, Hsin-Fen Hsu, Ronald B. Gartenhaus, Hsin-Ling Hsu. PS1059 - Alteration of mitochondria specific DNA post radiation Hengshan Zhang, David Maguire, Steven Swarts, Weimin Sun, Shanmin Yang, Wei Wang, Chaomei Liu, Mei Zhang, Peter Keng, Lurong 32

PS1060 - DNA damage-induced apoptosis in c3h mouse peritoneal resident macrophages Yoshihisa Kubota, Katsutoshi Suetomi, Akira Fujimori, Sentaro Takahashi. PS1061 - Increased chromosome instability and accumulation of DNA double-strand breaks in Werner syndrome cells Kentaro Ariyoshi, Shiraishi Kazunori, Keiji Suzuki, Makoto Goto, Masami Watanabe, Seiji Kodama. PS1062 - Biological studies using human cell lines and the current status of the microbeam irradiation system, SPICE Teruaki Konishi, Takahiro Ishikawa, Hiroyuki Iso, Nakahiro Yasuda, Shunsuke Okuma, Kumiko Kodama, Tsuyoshi Hamano, Noriyoshi Suya, Hitoshi Imaseki. PS1063 - Function of setd4 in DNA damage response Jinjiang Fan, Zhiyuan Shen. PS1064 - Mitochondrial DNA damage post exposure to simulated sunlight in human skin cells Luciene Zanchetta, James Walsh, Fiona Lyng, James Murphy. PS1065 - Detection of radiation-induced conformational changes in individual DNA molecules using a high-sensitivity flow ‘cytometer’

Monday

PS1056 - The effect of heavy-ions on synchronously dividing cell cultures Takamitsu A. Kato, Yoshihiro Fujii, Akira Fujimori, Ryuichi Okayasu.

Zhang, Paul Okunieff.

Robert C. Habbersett, James H. Jett, James P. Freyer.

PS1067 - Abrogation of radiation-induced S-phase checkpoint by oncogenic K-Ras Moon-Taek Park, Min-Jung Kim, Joo-Yun Byun, Sangwoo Bae, Chang-Mo Kang, In Chul Park, Gyesoon Yoon, Sang-Gu Hwang, Su-Jae Lee. PS1068 - Interactions between IR-induced p53 phosphoforms and ATM/53BPp1 complexes during DNA-dsb repair Robert G. Bristow, Shahnaz Al Rashid, Farid Jalali, Shane Harding, Nirmal Bhogal, Richard Hill. PS1069 - Tel2 mediates localization of Tel1 to sites of DNA damage Carol M. Anderson, Dana L. Smith, Svetlana Makovets, Dmitry Korkin, Andrej Sali, Elizabeth H. Blackburn. ______________________________________ PS1.6 - DNA Repair 1 PS1070 - Intervention of the repair factors of DNA double strand break to

PS1071 - Distinct roles of xrcc4 and ku80 in non-homologous endjoining of enzyme- and radiation-induced DNA double-strand breaks Jochen Dahm-Daphi, Leonie Schulte-Uentrop, Raafat A. ElAwady, Henning Willers. PS1072 - Speed of DNA double-strand break processing depends on age Olga Sedelnikova, Christophe Redon, Izumi Horikawa, Drazen Zimonjic, Nicholas Popescu, William Bonner. PS1073 - Human RAD18 is involved in single-strand break repair independent of PCNA monoubiquitination Tadahiro Shiomi, Naoko Shiomi, Masahiko Mori, Hideo Tsuji, Takashi Imai, Hirokazu Inoue, Satoshi Tateishi, Masaru Yamaizumi. PS1074 - NBS1 regulates the induction of apoptosis following radiation damage to DNA Kenta Iijima, Chizuko Muranaka, Junya Kobayashi, Shuichi Sakamoto, Kenshi Komatsu, Hiroshi Tauchi. PS1075 - Phosphorylation and kinase activity of DNA-PKCS regulate its dynamics at DNA double-strand breaks Eric Weterings. 33

Monday

PS1066 - Radiation-induced phosphorylated H2a.x foci in human keratinocyte cells expressing histone H2BGFP-tagged protein using the cenbg charged particle microbeam Hervé Seznec, Thomas Pouthier, Fredrik Andersson, Philippe Barberet, Sébastien Incerti, Philippe Moretto.

micronuclei derivation by radiation Tomohiro Yoshikawa, Genro Kashino, Koji Ono, Masami Watanabe.

PS1076 - A loss of function screening for radiation susceptibility genes Hitomi Sudo, Atsushi Tsuji, Aya Sgyo, Chizuru Sogawa, Tsuneo Saga, Yoshi-nobu Harada.

PS1078 - Repair of DNA-protein crosslinks: Roles of nucleotide excision and recombination repair systems Toshiaki Nakano, Soh Morishita, Hiroaki Terato, Bennet van Houten, Seung Pil Pack, Keisuke Makino, Hiroshi Ide. PS1079 - Missing links in the mechanism of DNA double-strand break repair through the non-homologous endjoining pathway Yoshihisa Matsumoto, Sushma M. Bhosle, Masanori Tomita, Norio Suzuki, Yoshio Hosoi, Kiyoshi Miyagawa. PS1080 - High expression of endogenous DNA repair complexes is associated with reduced DNA double-strand break rejoining but more accurate repair in irradiated murine embryonic stem cells Judit P. Banath, Susan H. MacPhail, Adriana Banuelos, Dmitry Klokov, Peggy L. Olive.

34

PS1082 - Roles of DNA repair genes in sustaining cell proliferation under low dose-rate irradiation Masanori Tomita, Yoshihisa Matsumoto, Kazuo Sakai. PS1083 - DNA double strand breaks inducing genomic instability in human cells Masamitsu Honma. PS1084 - Identification of radiation susceptibility gene of LEC rat by physical map construction and genome sequence comparison Aya Sugyo, Atsushi Tsuji, Hitomi Sudo, Masashi Sagara, Toshiaki Ogiu, Chizuru Sogawa, Tsuneo Saga, Yoshi-nobu Harada. PS1085 - Haplotype effects on chromosomal anomalies in heterozygous BRCA1-deficient primary human fibroblasts exposed to 29 kV mammography X-rays? Marlis Frankenberg-Schwager, Anke Gregus. PS1086 - Dynamic interactions of nonhomologous end-joining proteins with DNA ends Pierre-Olivier Mari, Bogdan I. Florea, Nicole S. Verkaik, Stephan P. Persengiev, Guido Keijzers, Adriaan B. Houtsmuller, Dik C. van Gent.

Monday

PS1077 - XRCC1 and XRCC3 variants and risk of glioma and meningioma Anne Kiuru, Carita Lindholm, Sirpa Heinävaara, Hannu Haapasalo, Tiina Salminen, Maria Feychting, Christoffer Johansen, Beatrice Malmer, Anthony Swerdlow, Anssi Auvinen.

PS1081 - Induction and persistence of Tcell receptor (TCR) variants in Xirradiated mice depends on p53 status Toshiyuki Norimura, Hiroyo Kakihara, Kazuyuki Igari, Ryuji Okazaki, Akira Ootsuyama.

PS1087 - Factors forming human individual radiosensitivity Natalia Ryabchenko, Emilia Dyomina.

PS1089 - Lucanthone and hycanthone affect apurinic endonuclease1(Ape1) by physical interaction Mamta D. Naidu, Rakhi Agarwal. Brookhaven National Lab, Upton, NY, USA. ______________________________________ PS1.7 - Experimental Therapeutics 1 PS1090 - 1-Methylxanthine enhances radiosensitivity of tumor cells by abrogating radiation-mediated G2 checkpoints Eun Kyung Choi, Seong-Yun Jeong, Jung Shin Lee, Yeon Hee Kook, So Lyoung Yi, Hyun Jin Ryu, Se Hee Son, Do Young Song, Sung Whan Ha, Heon Joo Park. PS1091 - Enhancement of radiationinduced cell killing by inhibiting G2 checkpoint with purvalanol A Daisuke Iizuka, Osamu Inanami, Mikinori Kuwabara.

PS1093 - Radiosensitization by temozolomide in human glioma cells is independent of MGMT promotor methylation status Krista van Nifterik, Jaap van den Berg, Lukas Stalpers, Theo Hulsebos, Sieger Leenstra, Laurine Wedekind, Najim Ameziane, Ben Slotman, Vincent Lafleur, Peter Sminia. PS1094 - Identification of novel mechanisms of radio-sensitization by histone deacetylase inhibitors in prostate cancer Seema Gupta, Ching-Shih Chen, Mansoor M. Ahmed. PS1095 - Inhibition of beta1 integrins in three-dimensionally cultured squamous cell carcinoma cells: A potent approach to enhance tumor cell radiation sensitivity Iris Eke, Yvonne Deuse, Nils Cordes. PS1096 - Enhancement of radiationinduced DNA damage and tumor cell cytotoxicity by gold and silver nanoparticles David G. Hirst, Fred Currell, Mansukhlal Shah, Margaret Brennan Fournet, Deirdre Ledwith. PS1097 - Pharmacological approaches for potentiating the radiosensitivity of human breast cancer cell lines. David Murray, Razmik Mirzayans. 35

Monday

PS1088 - Chicken DT40 PTIP-null mutants are viable, but defective in proliferation and highly sensitive to ionizing radiation Fumiko Morohoshi, Masanori Tomita, Kazutsune Yamagata, Mitsumasa Hashimoto, Kensuke Otsuka, Isamu Hayata, Kuniyoshi Iwabuchi, Hiroshi Tauchi, Kazuo Sakai.

PS1092 - Hydroxyethyldisulfide as a novel radiation sensitizer of human cancer cells Kathleen M. Ward, Jie Li, Iraimoudi S. Ayene.

PS1098 - Radiation-induced up-regulation of NQO1 enhances the cytotoxicity of β-lapachone Chang W. Song, Ki-Jung Ahn, Jihyung Choi, Minoru Suzuki, Kaoru Terai, Seung-Do Ahn, Eun Kyung Choi, Robert J. Griffin, Heon Joo Park.

PS1100 - High-throughput screening for the identification of novel radiosensitizing compounds in a head and neck cancer model David Katz, Carlo Bastianutto, FeiFei Liu. PS1101 - A small molecule high throughput screen for the identification of novel anticancer radiosensitizers Emma Ito, Fei-Fei Liu. PS1102 - Sodium selenite radiosensitizes prostate cancer xenograft tumors but does not kill intestinal stem cells in vivo Junqiang Tian, Bryan Husbeck, Donna Peehl, Susan Knox. PS1103 - Hypoxia-inducible suicide gene therapy approach radiosensitises prostate cancer cells Laure H. Marignol, Foley Ruth, Thomas D. Southgate, Mary Coffey, Donal Hollywood, Mark Lawler. 36

PS1105 - Cooperative effects of armed oncolytic adenovirus with radiotherapy in c3h/hej hepatocarcinoma Wonwoo Kim. PS1106 - SCC-S2 is a novel androgeninducible and multifunctional target: implications for radiation and chemo-sensitization of prostate cancer Chuanbo Zhang, Isamu Sakabe, Rajshree R. Mewani, Deepak Kumar, Usha N. Kasid. PS1107 - Guggulsterone mediated enhancement of radiation response Rajani Choudhuri, William DeGraff, James B. Mitchell, John A. Cook. PS1108 - The relation of p53 status to the radio- or thermo-enhancement effect by adriamycin (ADM) in human lung adenocarcinoma A549 cells and kinetics of apoptosis and hsp72 protein Sachiko Hayashi, Hideki Matsumoto, Masanori Hatashita. PS1109 - siRNA targeting NBS1 increases radiation sensitivity of human cancer cells in a p53-independent manner Ken Ohnishi, Zorica Scuric, Robert H. Schiestl, Akihisa Takahashi, Takeo Ohnishi.

Monday

PS1099 - Acidic microenvironment enhances radiosensitization of human melanoma cells by thermal sensitizers and the Hsp90 inhibitor, 17-AAG Ronald A. Coss, Dennis B. Leeper, Takahiro Sato, Christopher W. Storck.

PS1104 - Expression of mIL-3 enhanced a combined course of HSV-sr39tk gene therapy and radiotherapy for prostate cancer Chi-Shiun Chiang, Ching-Fang Yu, Sheng-Yung Fu, Ji-Hong Hong.

PS1110 - Effect of curcumin and ionizing radiation on the activation of wildtype and mutant p53 in prostate cancer cells Bijaya K. Nayak, Cynthia A. Galindo, Martin L. Meltz, Gregory P. Swanson.

PS1112 - Integrative Angio-Radiology in UNO-Agenda 21 Michael C. Michailov, Ursula E. Welscher, Eva M. Neu, Viktor Foltin, Walter Seidenbusch. PS1113 - Social Responsibility in Radiation Science for UNOAgenda 21 ICSD - Scientific Committee Int. Council Sci. Development ______________________________________ PS1.8 - Physics/Chemistry 1 PS1114 - Effect of DNA topology on double-strand breaks produced by γ radiation in plasmid DNA Pichumani Balagurumoorthy, S. James Adelstein, Amin I. Kassis. PS1115 - A comparison of DNA strand break yields in pBR322 plasmid after I-123 and I-125 decay Ekkehard Pomplun, Aude Peudon, Michel Terrissol, Eberhard Kümmerle.

PS1117 - Chemical yields of DNA strand breaks produced by the direct effect of ionizing radiation: a comparison between samples irradiated at 4 K followed by warming to room temperature with samples irradiated at room temperature Anita R. Peoples, Shubhadeep Purkayastha, Jamie R. Milligan, William A. Bernhard. PS1118 - Vibrational excitation of condensed thymidine films by low-energy electron impact Radmila Panajotovic, Marc Michaud, Leon Sanche. PS1119 - A new Monte Carlo program ETMICRO-CHEM for simulating DNA damage by electrons Eun-Hee Kim. PS1120 - Monte Carlo simulations of sitespecific radical attack to DNA bases Bulent Aydogan, Wesley E. Bolch, Steven G. Swarts, David T. Marshall. PS1121 - Monte-Carlo simulation of liquid water radiolysis: effects of acidity and radiation quality (LET) on the primary yields and application to the Fricke dosimeter Narongchai Autsavapromporn, Jintana Meesungnoen, Ianik Plante, Jean-Paul Jay-Gerin. 37

Monday

PS1111 - Integrative GenitouroRadioology in Uno-Agenda 21 Eva M. Neu, Michael Ch. Michailov, Guntram Schulz, Ianka Foltinova, Walter Seidenbusch.

PS1116 - The role of hydration in anion electron stimulated desorption from single strands of DNA Sylwia Ptasinska, Leon Sanche.

PS1122 - Water radiolysis by swift protons and carbon ions Benoit Gervais, Michael Beuve, Anthony Colliaux. PS1123 - Ionization by intermediateenergy carbon ions on water vapor Steven L. McLawhorn, Larry H. Toburen, Robert A. McLawhorn, Edson L. Justiniano, Jefferson L. Shinpaugh.

PS1125 - Oxidative degradation property of sulfonated fep / nafion hybrid proton exchange membranes for pefc Naohiro Mitani, Yukiko Sato, Kazuki Fujii, Yuji Oshima, Jingye Li, Akihiro Oshima, Masakazu Washio. ______________________________________ PS1.9 - Radiation Carcinogenesis 1 PS1126 - A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident: Dose-response analysis of thyroid follicular adenomas detected during first screening in Ukraine (1998-2000) Lydia Zablotska. PS1127 - Gastric cancer risk in relation to atomic-bomb radiation and the other risk factors -a nested casecontrol study 38

PS1128 - Non-cancer effects in the cohort of workers of the first Russian nuclear facility Tamara V. Azizova, Colin R. Muirhead, Maria B. Druzhinina, Evgenia S. Grigoryeva, Elena V. Vlasenko, Margarita V. Sumina, Zinaida D. Belyaeva, Jackie A. O’Hagan, Wei Zhang, Richard G.E Haylock. PS1129 - Multivariate analysis of effects of radiation and non-radiation risk factors on kidney cancer incidence among Mayak PA nuclear workers Galina V. Zhuntova, Zoya B. Tokarskaya, Zinaida D. Belyaeva, Evgenia S. Grigoryeva, Viktor A. Syrchikov. PS1130 - Minimize offspring radiation exposure following intake of radionuclides by the mother Hamid Samavat, Ali Shabestani Monfared. PS1131 - Environmental radiation and breast cancer incidence in the Techa River Cohort Evgenia Ostroumova, Dale Preston, Elaine Ron, Ludmila Krestinina, Faith Davis, Alexander Akleyev. PS1132 - Considerations in the comparison of cancer risk estimates for a Japanese Thorotrast cohort and the Atomic Bomb Survivors

Monday

PS1124 - New superparamagnetic polymer nanospheres for the potential separation of radionuclides in nuclear wastes or environmental samples Yanqin Ji, Xianzhang Shao, Jinying Li, Yueping Guan.

Saeko Fujiwara, Gen Suzuki, Harry Cullings, Nobuo Nishi, Midori Soda, Eiichi Tahara.

Harry M. Cullings, Takesaburo Mori, John B. Cologne, Yukiko Shimizu. PS1133 - Combination study of indoor radon, gamma activity & inhalation doses in the dwellings of Punjab and Tusham Ring Complex, Haryana Bikram jit Singh Bajwa, Harmanjit Singh Sandhu, Joga Singh.

PS1135 - Association of radiation exposure, inflammation, and cancer incidence in atomic bomb survivors - an application of causal pathway model Kazuo Neriishi, Wan-Ling Hsu, Nobuo Nishi. PS1136 - Projected update of the National Institutes of Health radioepidemiological tables and interactive radioepidemiological program (IREP) Charles E. Land, Ethel S. Gilbert, Deukwoo Kwon, F Owen Hoffman, Apostoaei Iulian, Brian Thomas, David C. Kocher. PS1137 - Longitudinal trends of total white blood cell and differential white blood counts of atomic bomb survivors

PS1138 - Gene alterations preferentially occurred in adult-onset papillary thyroid cancer among atomic bomb survivors Kiyohiro Hamatani, Hidetaka Eguchi, Masatak Taga, Keiko Takahashi, John Cologne, Midori Soda, Kuniko Abe, Tomayoshi Hayashi, Koji Arihiro, Yuzo Hayashi, Kei Nakachi. PS1139 - Effects of inflammation-related gene polymorphisms and atomicbomb radiation exposure on gastric cancer risk Tomonori Hayashi, Yukari Morishita, Hiroko Nagamura, Mayumi Maki, Misae Sora, Kazue Imai, Kengo Yoshida, Yoichiro Kusunoki, Eiichi Tahara, Kei Nakachi. PS1140 - Fate of irradiated human fibroblasts: senescence or genetic instability and crisis? Claudia Fournier, Marcus Winter, Sebastian Zahnreich, Sylwester Sommer, Larissa Melnikova, Elena Nasonova, Sylvia Ritter. PS1141 - Microsatellite instability and related gene alterations in radiation-associated colorectal cancer from atomic-bomb survivors Hidetaka Eguchi, Kiyohiro Hamatani, Masataka Taga, Hiroaki Katayama, Kazunori Kodama, Eiichi Tahara, Shizue Izumi, Shunji Matsumura, Naohide Oue, Wataru Yasui, Kei Nakachi. 39

Monday

PS1134 - Lung cancer mortality after exposure to fractionated ionizing radiation in a cohort of Massachusetts tuberculosis patients Alina V. Brenner, Ethel S. Gilbert, Charles E. Land.

Wan-Ling Hsu, Yoshimi Tatsukawa, Michiko Yamada, Kazuo Neriishi.

PS1148 - Standardized North American ginseng radioprotects human lymphocytes Tung-Kwang Lee, Ron R. Allison, Weidong Wang, Kevin F. O'Brien, Roberta M. Johnke.

PS1143 - Interaction among genes influences DNA repair capacity in young lung cancer patients Sabine Hornhardt, Ute Roessler, Albert Rosenberger, Wiebke Sauter, Heike Bickeboeller, Thomas Illig, Heinz-Erich Wichmann, Maria Gomolka. ______________________________________

PS1149 - The effect of natural products on hemopoietic function in irradiated mice Yue Gao.

PS1.10 - Radioprotectors/Mitigators 1

PS1151 - Radioprotective effects of an Ulmi Cortex Extract and the identification of its effective compounds Uhee Jung, Hae-Ran Park, Yoon-Ah Lee, Seol-Hee Han, Sung-Kee Jo.

PS1144 - Radiomodulatory effect of Grewia asiatica on liver of Swiss albino mice K.V. Sharma, Muktika Ahaskar, Smita Singh, Rashmi Sisodia. PS1145 - Dietary influence of Grewia asiatica against radiation induced damage on non-cell renewal system of swiss albino mice Muktika Ahaskar, K.V. Sharma, Smita Singh, Rashmi Sisodia. PS1146 - Role of Grewia asiatica as a potent radioprotector Smita Singh, K.V. Shrama, Muktika Ahaskar, Rashmi Sisodia. PS1147 - Radioprotective effects of mentha piperita linn in vivo: studies in swiss albino mice Ravindra M. Samartha, Meenakshi Panwar, Madhu Kumar, Ashok Kumar. 40

PS1150 - Protection against radiation by Rosemarinus officinalis (a medicinal plant) extract P. K. Goyal.

PS1152 - Radioprotective and antimutagenic effects of Oltipraz Ashok Kumar, Ravindra Samarth, Madhu kumar, Deepali Sharma, Patrick Prendergast, Hiroshi Kimura. PS1153 - Radioprotection of lactoferrin in sub-lethally x-ray irradiated mice Yoshikazu Nishimura, Shino Homma-Takeda, Izuru Kakura, Hee Sun Kim, Minako Nyui, Nobuo Ikota. PS1154 - Myristica fragrans: a possible radiomodulator in the testis of swiss albino mice Madhu Kumar, Mini Sharma.

Monday

PS1142 - Chromosome mutations in iss crew members participating in short duration missions Wolfgang Goedecke, Alexandra Antonopoulos, Markus Horstmann, Guenter Obe, Christian Johannes.

PS1155 - Radiomodulatory effect of leaf extract of mentha piperita (linn) in Swiss albinio mice Punar Dutt Meena, Pallavi Kaushik, Anil Soni, Shalini Shukla, Ashok Kumar.

PS1157 - Natural protectors: cytogenetic assessment of radioprotector effect of ethanol extract of propolis Alegria Montoro. PS1158 - In search of new radio-protecting agents Jaroslaw Dziegielewski, Umut Aypar, Janet E. Baulch, Kurtis E. Bachman, William F. Morgan. PS1159 - Development of a primate resource for radiation countermeasures research Shauna Gray, Esther Arifin, Dan Bourland, Tom Register, Jan Wagner, Mark Cline. PS1160 - A soluble peptide (EA230) protects WBI-induced toxicity in a post scenario application Alan A. Alfieri, Laibin Liu, Payel Bhanja, Zsolt Harsanyi, Richard Carlton, Chandan Guha. PS1161 - Adaptation of the yeast DEL assay for rapid identification of radiation protectors and sensitizers

PS1162 - Pulse radiolysis of polystyrene and derivatives Kazumasa Okamoto, Masafumi Tanaka, Shu Seki, Takahiro Kozawa, Seiichi Tagawa. PS1163 - Selective protection of normal tissues from lethal irradiation by pharmacological imitation of tumor mechanisms suppressing apoptosis Andrei Gudkov, Elena Komarova, Lyudmila Burdelya, Vadim Krivokrysenk, Joseph DiDonato, Alexander Shakhov, Elena Feinstein. ______________________________________ PS1.11 - Signaling 1 PS1164 - Modulation of radiation sensitivity by down-regulation of the PI3K/Akt signalling pathway Carsten Herskind, Meng Wang, Qi Liu, Christina Ganasinski, Patrick Maier, Frederik Wenz, Frank Lohr. PS1165 - An essential role of integrinlinked kinase on the cellular radiosensitivity during the process of cell adhesion and spreading Stephanie Hehlgans, Iris Eke, Nils Cordes. PS1166 - Modulation of irradiationinduced microglial inflammation by PPARα activation Sriram Ramanan, Mitra Kooshki, Weiling Zhao, Michael E. Robbins.

41

Monday

PS1156 - Radioprotective effect of mentha piperita in swiss albino mice Pallavi Kaushik, Punar Dutt Meena, Shalini Shukla, Ashok Kumar.

Kurt Hafer, Nikos Hontzeas, Robert Schiestl.

PS1167 - The involvement of protein kinase C alpha in radioadaptive response Akira Tachibana, Katsuyuki Ito, Hiroshi Tauchi, Masao S. Sasaki.

PS1169 - Altered phosphorylation of p53 in Nijmegen breakage syndrome cells Luitpold V. Distel, Matthias Uhl, Anne Hofmann, Ulrike Keller, Leonhard Kuehn, Rolf Sauer, Gerhard G. Grabenbauer. PS1170 - The effect of radiation and repeated sub-culturing on TGF-β1 signaling in FRTL-5 cells Cheryl G. Burrell, Leticia Ortloff, Lora Green. PS1171 - p38MAPK plays a cytoprotective role in response to radiation through Akt activation in human cervical cancer cells Min-Jung Kim, In-Chul Park, Chang-Mo Kang, Sangwoo Bae, Yun-Sil Lee, Sang-Gu Hwang, SuJae Lee. PS1172 - Knock down of the TGFβ type III receptor results in modulation of NFkB signaling and radio-

42

PS1173 - Src tyrosine kinase inhibitor PP2 suppresses activation of ERK1/2 and epidermal growth factor receptor induced by X-irradiation Yoshio Hosoi, Kiyoshi Miyagawa. PS1174 - Developing novel imaging techniques to study radiation induced signaling in 3D model systems Marianne B. Sowa, Lee Opresko, Derek F. Hopkins, H. Steven Wiley. ______________________________________ PS1.12 - Technical Advances/Imaging/Models 1 PS1175 - Tumor hypoxia, necrosis and targeting: it's the gradient, dummy John P. Kirkpatrick, Thies Schroeder, Mark Oldham, Mark W. Dewhirst. PS1176 - LSDCAS studies of cells undergoing reductive division following radiation-induced mitotic catastrophe Fiorenza Ianzini, Elizabeth A. Kosmacek, Jennifer M. Symonds, Paul J. Davis, Michael A. Mackey. PS1177 - Imaging of the redox state and of hypoxia in human head and neck tumor xenografts Ala Yaromina, Ulrike Sattler, Verena Quennet, Christian Hoerner, Daniel Zips, Stefan Walenta, Michael Baumann, Wolfgang Mueller-Klieser.

Monday

PS1168 - Low-dose of ionizing radiation enhances cell proliferation through Ikaros phosphorylation in IM-9 B lymphoblast cells Min Young Kim, Kwang Hee Yang, Sung-Ryul Lee, Seon Young Nam, Meeseon Jeong, Cha Soon Kim, Hee Sun Kim, Young-Woo Jin, Suhkneung Pyo, Chong Soon Kim.

resistance of normal mouse mammary epithelial cells Tracy Criswell, Carlos L. Arteaga.

PS1178 - Temporal changes in tumor blood supply measured in A-07 melanoma xenografts Kjetil G. Brurberg, Camilla Mollatt, Jon-Vidar Gaustad, Einar K. Rofstad.

PS1180 - Spatiotemporal imaging of hif-1 mediated tumor cell-stromal adaptation to hypoxia following radiation David L. Schwartz, Jung Hwan Oh, Ryan Williams, Yi He, Robert Lemos, Norihito Kuno, Sunil Krishnan, William Bornmann, Edward Jackson, Garth Powis, Juri Gelovani.

PS1184 - Molecular probe for the detection of hydroxyl radicals (•OH) within DNA Amarjit Singh, Yongliang Yang, Pichumani Balagurumoorthy, S. James Adelstein, Amin I. Kassis. PS1185 - Optical analyses of radiobiological effects in irradiated cellular systems Aidan D. Meade, Hugh J. Byrne, Fiona M. Lyng.

PS1181 - Use of optical spectroscopy for characterization of tumor oxygenation and metabolic redox ratio Gregory M. Palmer, Ronald J. Viola, Thies Schroeder, Pavel S. Yarmolenko, Lauren E. Tochacek, Nimmi Ramanujam, Mark W. Dewhirst.

PS1186 - Targeted Therapeutic Evaluation on Inhibition of Fatty Acid Synthase in a Human Prostate Carcinoma LNCaP/tk-luc bearing animal model with Molecular Imaging Wen-Tien Tai, Ya-Fang Chang, JyhDer Leu, Jeng-Jong Hwang.

PS1182 - Does [18F]FDG-uptake predict therapy response to single dose irradiation in FaDu tumors in nude mice? Bettina Beuthien-Baumann, Christina Schuetze, Ralf Bergmann, Franziska Hessel, Michael Baumann.

PS1187 - Primary tumor volume measurements of nasopharyngeal carcinoma determined with computed tomography: study of variability Cheng-Chaun Chang, Mu-Kuan Chen, Hwa-Koon Wu. 43

Monday

PS1179 - Fraction of radiobiologically hypoxic cells and fluctuations in tumor blood perfusion assessed by dynamic contrast-enhanced MRI Jon-Vidar Gaustad, Kjetil G. Brurberg, Tormod A. M. Egeland, Ilana C. Benjaminsen, Einar K. Rofstad.

PS1183 - Molecular imaging of a murine monoclonal antibody that binds to the β3 subunit of αvβ3 integrin in the experimental model of the Lewis lung cancer in mice Marek Bilski, Ireneusz P. Grudzinski, Urszula Karczmarczyk, Robert Zdanowski, Jacek Pietrzykowski, Renata Mikolajczak, Piotr Garnuszek, Eugeniusz Dziuk, Marek P. Dabrowski, Marek K. Janiak.

PS1188 - Application of a high-brightness electrodeless z-pinch soft x-ray source to water window imaging and microbeam research Stephen F. Horne, Matthew M. Besen, Robert D’Agostino, Donald K. Smith, Paul Blackborow.

PS1189 - Curcumin disrupts radiation induced positive feed back (NFκBTNFα-NFκB) cycle and inhibits NFκB mediated radio-adaptation in neuroblastoma cells Natarajan Aravindan, Rakhesh Madhusoodhanan, Salahuddin Ahmad, Daniel Johnson, Terence Herman.

Monday

44

Tuesday, July 10, 2007 7:30am - 8:15am Eye Openers EO 5: Target for radiation cell kill: rafts or DNA? Salon 7, Yerba Buena Richard Kolesnick, Memorial Sloan-Kettering Cancer Center, New York, USA Chair: Wayne Zundel, University of Colorado Health Science Center, Denver, USA ______________________________________

EO 7: Low dose radiation exposure, polymorphisms and thyroid cancer risks Salons 1, 2, 3 Yerba Buena Alice Sigurdson, NCI, NIH, Bethesda, USA Chair: David Brenner, Columbia University, New York, USA ______________________________________ 8:30am - 9:30am Congress Lectures CL 7: DNA damage responses: mechanisms and implications for human disease Salon 7, Yerba Buena Michael Kastan, St. Jude’s Children's Hospital, Memphis, USA Chair: Martin Lavin, Queensland Radium Institute, Brisbane, Australia

CL 9: Extrapolation of radiation induced cancer risks from low doses to very low doses: what does science tell us? Salon 8, Yerba Buena David J. Brenner, Columbia University, New York, USA Chair: Roger Martin, Peter MacCallum Cancer Institute, Melbourne, Australia ______________________________________ CL 10: Integrating molecular therapeutics with radiotherapy Salons 4, 5, 6 Yerba Buena Kie-Kian Ang, University of Texas MD Anderson Cancer Center, Houston, USA Chair: Theodore Phillips, University of California, San Francisco, San Francisco, USA ______________________________________ CL 11: Integrative radiation biology Salons 1, 2, 3 Yerba Buena Mary Helen Barcellos-Hoff, Lawrence Berkeley National Lab, Berkeley, USA Chair: Noelle Metting, Department of Energy, Washington, DC, USA ______________________________________

45

Tuesday

EO 6: Heavy ion radiobiology in therapy and space Salon 8, Yerba Buena Marco Durante, University of Naples Federico II, Naples, Italy Chair: Francis A. Cucinotta, Johnson Space Center, NASA, Houston, USA ______________________________________

CL 8: Radiation damage and formation of trans fatty acids in membranes: biomimetic and in vivo studies Salon 15, Yerba Buena Carla Ferreri, Consiglio Nazionale delle Ricerche, Bologna, Italy Chair: Chantal Houee-Levin, University of Paris Sud, Orsay, France ______________________________________

CL 12: Chromatin remodeling complexes: essential components of DNA damage Salons 10, 11 Yerba Buena Brendan Price, Dana Farber Cancer Institute, Boston, USA Chair: Peggy Olive, BC Cancer Research Centre, Vancouver, Canada ______________________________________ 10:00am - 12:00pm Symposia S 13: Structural Aspects of RadiationInduced DNA Damage and Repair Salons 1, 2, 3 Yerba Buena Chair: Melanie Spotheim-Maurizot, Centre National de la Recherche Scientifique, Orleans, France

10:00 - Application of SHIELD-HIT, MCNPX, and GEANT4 for ion transport calculations in radiation therapy and space Irena Gudowska, Karolinska Institute and Stockholm University, Stockholm, Sweden 10:30 - The International Commission Radiological Protection Task Group on international guidelines for space missions Guenther Dietze, PhysikalischTechnische Bundesanstalt, Braunschweig, Germany 11:00 - Late effects of heavy ion exposures Eleanor Blakely, Lawrence Berkeley National Lab, Berkeley, USA

10:30 - How is radiation affecting the protein-bodyguard of DNA? Melanie Spotheim-Maurizot, Centre National de la Recherche Scientifique, Orleans, France

11:30 - Heavy ion effects to the central nervous system Greg Nelson, Loma Linda University, Loma Linda, USA ______________________________________

11:00 - Fidelity and mutagenicity in Yfamily polymerases Roman Osman, Mount Sinai School of Medicine, New York, USA

S 15: New Data for Cancer Risk Assessment Salon 7 Yerba Buena Chair: Elaine Ron, NCI, National Institutes of Health, Bethesda, USA

11:30 - Modeling radiation-induced chromosome aberration induction Francesca Ballarini, National Institute of Nuclear Physics, Pavia, Italy 46

10:00 - Cancer incidence in the atomic bomb survivors: the new incidence report Kiyohiko Mabuchi, RERF, Hiroshima, Japan

Tuesday

10:00 - Predicting DNA damage by a structure based Monte-Carol simulation method based on molecular structures of DNA or DNA-protein complexes Marie Davidkova, Nuclear Physics Institute, Prague, Czech Republic

S 14: Heavy Ion Radiobiology in Therapy and Space Salons 10, 11 Yerba Buena Chair: Yoshiya Furusawa, National Institute of Radiological Sciences, Chiba, Japan

10:30 - Cancer risks from radiation exposure in the former Soviet Union (Mayak nuclear workers Techa river residents, Chernobyl) Elaine Ron, NCI, National Institutes of Health, Bethesda, USA 11:00 - Cancer risk estimation derived from studies of nuclear workers Mary Schubauer-Berigan, National Institute for Occupational Safety and Health, Cincinnati, USA 11:30 - Cancer risk from diagnostic X-rays Amy Berrington de Gonzalez, Johns Hopkins University, Baltimore, USA ______________________________________

10:00 - Developing novel targets: lesson learned from HIF-1 Ben Moeller, University of Texas MD Anderson Cancer Center, Houston, USA 10:30 - DNA replication repair: from molecular insights towards new approaches to anti-cancer therapy Thomas Helleday, University of Oxford, Oxford, UK 11:00 - Assessment of novel hypoxia response pathways as clinical molecular targets Brad Wouters, University of Maastricht, Maastricht, The Netherlands

S 17: New Directions in Hyperthermia Salons 12, 13 Yerba Buena Chair: Ellen Jones, Duke University, Durham, USA 10:00 - Immunological effects of hyperthermia – multifaceted features that augment anti-tumor immunity Elizabeth Repasky, Roswell Park Cancer Institute, Buffalo, USA 10:30 - Progress in non-invasive thermometry for hyperthermia Peter Wust, Charite Universitatsmedizin Berlin, Berlin, Germany 11:00 - Design and testing of novel thermally sensitive liposomal formulations for the treatment of local tumors: a new paradigm for drug delivery David Needham, Duke University, Durham, USA 11:30 - Regional hyperthermia combined with systemic chemotherapy in the management of locally advanced, high grade soft tissues sarcomas of the extremities, the body wall and the abdomen: a phase III randomized prospective trial (EORTC-SCHO Intergroup Trial) Rolf Issels, University of Munich, Munich, Germany ______________________________________ 47

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S 16: Molecular Targets for Radiosensitization Salons 8 Yerba Buena Chair: Gillies McKenna, University of Oxford, Oxford, UK

11:30 - Modulating radiation resistance: Is AKT the target? Anjali Gupta, University of Pennsylvania, Philadelphia, USA ______________________________________

S 18: Studies of In Utero Radiation Effects Salons 4, 5, 6 Yerba Buena Chairs: Jack Schull, The Schull Institute, Houston, USA Roy Shore, RERF, Hiroshima, Japan

2:00pm - 4:00pm Symposia

10:00 - Cancer incidence and mortality after in-utero atomic bomb exposures Dale Preston, Hirosoft Inc., Seattle, USA

2:00 - Formation and biological consequences of peroxide formation on proteins by radiation Michael Davies, University of Sydney, Sydney, Australia

10:30 - Chromosome aberration induction following fetal radiation exposure in mice and humans Nori Nakamura, RERF, Hiroshima, Japan

2:30 - Once electron oxidation of peptides: role of oxygen Chantal Houee-Levin, University Paris Sud, Orsay, France

11:00 - Early molecular radiation events in embryogenesis Ohtsura Niwa, Kyoto University, Kyoto, Japan

3:00 - Tryptophan-mediated photolysis of disulfide bridges in proteins and peptides Ignace Hanssens, Katholieke Universiteit Kortrijk, Leuven, Belgium

12:00pm - 1:00pm Plenary Lecture Salon 9 Yerba Buena PL 3: The biophysical method KU proteins use to test for the fidelity of DNA repair Steven Chu, Lawrence Berkeley National Laboratory, Berkeley, USA Chair: Herwig Paretzke, GSF-National Research Center for Environment and Health, Neuherberg, Germany ______________________________________ 48

3:30 - Selective protein oxidation in vivo: targets and novel analytical methodology Christian Schoneich, University of Kansas, Lawrence, USA ______________________________________ S 20: Cardiovascular Late Effects of Radiation Salon 7 Yerba Buena Chair: Kei Nakachi, RERF, Hiroshima, Japan 2:00 - Cardiovascular disease in the atomic bomb survivors: mortality, morbidity and laboratory findings and its association with atomic bomb radiation Kazunori Kodama, RERF, Hiroshima, Japan

Tuesday

11:30 - Fetal irradiation effects on the developing brain Louis de Saint-Georges, Belgian Nuclear Research Centre, Mol, Belgium ______________________________________

S 19: Current Topics in Protein Damage Salon 15 Yerba Buena Chair: Christian Schoneich, University of Kansas, Lawrence, USA

2:30 - Radiation exposure and cardiovascular disease risks Sarah Darby, Medical Research Council, Oxford, UK 3:00 - Radiotherapy and cardiovascular outcomes Steven Lipshultz, University of Miami, Miami, USA 3:30 - Biology of cerebrovascular effects Fiona Stewart, Netherlands Cancer Institute, Amsterdam, The Netherlands ______________________________________ S 21: How to Translate Molecular Targeting into Radiotherapy Salon 8 Yerba Buena Chair: Michael Baumann, University of Dresden, Dresden, Germany

2:30 - Biology-driven early clinical trials for radiotherapy Paul Harari, University of Wisconsin, Madison, USA 3:00 - Preclinical evaluation in the specific context of radiotherapy Michael Baumann, University of Dresden, Dresden, Germany 3:30 - Early clinical translational trials Jean Bourhis, Institut Gustave Roussy, Villejuif, France ______________________________________

2:00 - Realizing the mechanism of low dose hyperradiosensitivity Brian Marples, Beaumont Hospital, Troy, USA 2:30 - Molecular basis for low dose radiation hypersensitivity Mike Weinfeld, Cross Cancer Institute, Edmonton, Canada 3:00 - Chemopotentiation effects of lowdose hypersensitivity make headway in cancer therapy Mansoor Ahmed, Geisinger Clinic, Danville, USA 3:30 - Low dose total body irradiation in patients of advanced relapsed/refractory non-hodgkins lymphoma: a preliminary clinicoradiobiology report Mohindra Pranshu, Tata Memorial Hospital, Mumbai, India ______________________________________ 2:00pm - 4:00pm Workshops What’s the Latest on ATM? Salons 4, 5, 6 Yerba Buena Chairs: Martin Lavin, Queensland Institute of Medical Research, Brisbane, Australia Patrick Concannon, University of Virginia, Charlottesville, USA ______________________________________ 49 W 1:

Tuesday

2:00 - Molecular targeting and radiation: from bench to bedside Daphne Haas-Kogan, University of California, San Francisco, San Francisco, USA

S 22: Low Dose Hypersensitivity: Mechanisms and Clinical Applications Salons 1, 2, 3 Yerba Buena Chairs: Michael Joiner, Wayne State University, Detroit, USA Kaushala Prasad Mishra, Bhabha Atomic Research Centre Trombay, Bombay, India

New Technology in Sub-Cellular Microbeams Salons 10, 11 Yerba Buena Chairs: Zbigniew Stachura, Henryk Niewodniczanski Institute of Nuclear Physics, Krakow, Poland. Gerhard Randers-Pehrson, Columbia University/RARAF, New York, USA ______________________________________ W 2:

How Can We Update Track Structure Codes to Include and Test Current Reactions Mechanisms in DNA and Related Systems? Salons 14 Yerba Buena Chairs: Hooshang Nikjoo, NASA Johnson Space Center, Houston, USA William Bernhard, University of Rochester, Rochester, USA ______________________________________ W 3:

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A non-homogeneous tour of radiation research: on the tracks to complex systems dynamics Herwig Paretzke, GSF-National Research Center for Environment and Health, Neuherberg, Germany Chair: Bill McBride, University of California, Los Angeles, Los Angeles, USA ______________________________________ 6:30pm - 7:15pm Weiss Medal Lecture (ARR) Salon 9 Yerba Buena A circuitous journey through haematology and radiation biology Eric Wright, University of Dundee, Scotland ______________________________________

Tuesday

4:00pm - 5:30pm Poster Session 2 ______________________________________

5:45pm - 6:30pm Failla Award Lecture (RRS) Salon 9 Yerba Buena

RRS Failla Award

The Failla Award was established by the Radiation Research Society in 1962 to honor Dr. Gioacchino Failla and was first given in 1963. The award is given annually to an outstanding member of the radiation research community in recognition of a history of significant contributions to radiation research. Dr. Failla was one of the greatest pioneers in the fields of biophysicds and radiobiology. Dr. Failla was the first to suggest that radiation doses be expressed as the amount of radiation energy absorbed and made the first dose estimates in radium therapy in terms of microcalories per cc of tissue. Not the least of his contributions were his roles in founding the International Commission on Radiation Units and Measurements (ICRU), and the Radiation Research Society.

radiation research in Germany (GSF-ISS), and an honorary professor at the Physics Department of the Technical University of Munich. He is honored for his pioneering work in detailed Monte-Carlo charged particle track structure simulation codes (MOCA and PARTRAC) to quantitatively test working hypotheses on basic radiobiological phenomena on a nanometer scale and with realistic sub-cellular geometries and for his innovative modelling of low dose radiation carcinogenesis. He is the chairman of the German Association of Radiation Research (GAST) and of the Division of Radiation and Medical Physics of the German Physical Society. He is a member of the International Commission of Radiation Units and Measurements ICRU, and until recently of the ICRP. Dr. Paretzke has published some 300 peer-reviewed articles, supervised more than 40 PhD and diploma theses, and organized about 50 well attended international workshops and conferences. He has received a number of awards including from the American Health Physics Society and the International Radiation Protection Association. 51

Tuesday

Dr. Herwig G. Paretzke, this year's awardee, is director of the largest institute of

ARR Weiss Medal

The Weiss Medal was established by the Association for Radiation Research in 1972 to honor the memory of Professor J. Weiss, late Professor of Radiation Chemistry at the University of Newcastleon-Tyne. Dr. Weiss’s researches with Haber in the 1930's are widelyknown as landmarks in chemical science. For over twenty-five years he published many distinguished papers in radiation chemistry and was the first radiation chemist to attempt to unravel systematically the complex interaction between biologically important molecules and free radicals produced upon the radiolysis of water.

Dr. Eric Wright, this years recipient of the Weiss medal, is honoured for his

instability in relation to the development of leukaemia and other diseases. Dr. Wright is Professor of Experimental Haematology at the University of Dundee Medical School. He is a graduate of the University of Sussex and obtained his PhD from the University of Manchester. Professor Wright is the Director of the Leukaemia Research Fund's Specialist Programme in Radiation Leukaemogenesis and he is the recipient of The David AndersonBerry Medal of The Royal Society of Edinburgh and a Fellow of the Royal Society of Edinburgh. In recent years he has been a member of the UK Government Committee Examining the Radiation Risks of Internal Emitters (CERRIE), and Chairs of the Radiation and Cancer Biology Committee of The British Institute of Radiology, and of the Trustees of the LH Gray Memorial Trust.

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outstanding work on cellular, genetic and molecular respects of radiation-induced genomic

Poster Session 2 PS2.1 - Biodosimetry 2 PS2001 - Robotic blood handling in a cytogenetic biodosimetry laboratory for dose assessment in radiological and nuclear mass casualties. Pataje G. Prasanna, Patrick R. Martin, Uma Subramanian, Maria Moroni, Roman E. Berdychevski. PS2002 - An improvement of the metaphase finder system for the biological dosimetry by chromosome aberration Akira Furukawa, Masako Minamihisamatsu, Isamu Hayata.

PS2004 - The automatic dicentric detection system efficiency in a real case population triage Laurence Roy, Aurélie Vaurijoux, Eric Grégoire, Cécile Martin, Pascale Voisin, Sandrine Roch-Lefevre, Partick Gourmelon.

PS2006 - Achieving requirements for dosimetry for management of potential radiation exposures to a large population with EPR technqiues Harold M. Swartz, Artur Sucheta, Ruhong Dong, Eugene Demidenko, Ben Williams, Piotr Lesniewski, Maciej Kmiec, Yasuko Sakata. PS2007 - Fully-automated rapid in-situ cellular imaging for a highthroughput biodosimetry workstation Oleksandra V. Lyulko, Guy Garty, Gerhard Randers-Pehrson, David J. Brenner. PS2008 - Validation of high throughput micronucleus analysis in peripheral reticulocytes for radiation biodosimetry Yuhchyau Chen, Ollivier Hyrien, Irena Nowak, Ying Tsai, Nancy Wang, Ruth Wilkins, Catherine Ferrarotto, Stephen Dertinger. ____________________________________

PS2005 - Development of an ultrahighthroughput robotically-based biodosimetry workstation using insitu assays. 53

Tuesday

PS2003 - Rapid and accurate in vivo tooth dosimetry: experimental procedure for positioning the resonator Ruhong Dong, Artur Sucheta, Eugene Demidenko, Benjamin B. Williams, Maciej Kmiec, Gregory Burke, Piotr Lesniewski, Firdus F. Gubaydullin, Andres Ruuge, Harold M. Swartz.

Guy Garty, Gerhard RandersPehrson, Oleksandra V. Lyulko, Aparajita Dutta, Jing Nie, Giuseppe Schettino, Anubha Bhatla, Jian Zhang, Alessio Salerno, Nabil Simaan, Y. Lawrence Yao, David J. Brenner.

PS2.2 - Bystander Effects 2 PS2009 - Oxidative effects related to proton irradiation in hepatoma cell line at the Lund Nuclear Probe Natalia Arteaga-Marrero, Magnus G. Olsson, Jan Pallon, Bo Akerstrom, Mikael Elfman, Per Kristiansson, Charlotta Nilsson, Christer Nilsson, Marie Wegdén. PS2010 - Mechanisms underlying αparticle induced bystander effects in normal human fibroblasts Zhi Yang, Perumal Venkatachalam, Sonia M. de Toledo, John B. Little, Edouard Azzam.

PS2012 - Functional genomics of the radiation bystander response in normal human fibroblasts and epithelial cells Shanaz A. Ghandhi. PS2013 - Radiation induced bystander effect in plants is generated by radicals formed in irradiated media Igor Kovalchuk, Franz Zemp, Trang Bui. PS2014 - Role of epigenetic effectors in the radiation-induced bystander effects in vivo Olga Kovalchuk, Igor Koturbash, Yaroslav Ilnystky, Kristy R. Kutanzi, Igor Pogribny. 54

PS2016 - Proteome analysis of proliferative response of bystander cells adjacent to cells exposed to ionizing radiation Bogdan I. Gerashchenko, Akira Yamagata, Ken Offusa, Katsutoshi Yoshizato, Sonia M. de Toledo, Roger W. Howell. PS2017 - Molecular mechanisms of the sex differences in the radiation induced bystander effect in vivo Igor Koturbash, Kristy Robin Kutanzi, Karl Hendrickson, Dmitriy Kogosov, Olga Kovalchuk. PS2018 - Imaging of chemical and structural aspects of low-LET bystander effects in living mammary epithelial cells Hoi-Ying N. Holman, Kathy A. Bjornstad, Al C. Thompson, Chris J. Rosen, Eleanor A. Blakely. PS2019 - DNA double-strand break formation in normal human fibroblasts can be triggered by exposure to human cancerous cultured cells in a bystander-like effect Mykyta Sokolov, Olga Sedelnikova, William Bonner. ______________________________________

Tuesday

PS2011 - Caspases are involved in the induction of apoptosis in irradiated and bystander cells Martin Purschke, Zhixiang Zhou, Kathryn D. Held.

PS2015 - The role of miRNAs in the epigenetic regulation of bystander responses in 3D human tissue models Franz J. Zemp, Jennifer Dickey, Gloria Jenkins-Baker, Stephen A. Marino, David J. Brenner, William M. Bonner, Olga A. Sedelnikova, Olga Kovalchuk.

PS2.3 - Cell Behavior/Stem Cells 2 PS2020 - Effect of low dose of X rays and/or microwaves on human blood mononuclear cells in vitro Wanda Stankiewicz, Aneta Cheda, Ewa M. Nowosielska, Jolanta Wrembel-Wargocka, Marek P. Dabrowski, Roman Kubacki, Marek K. Janiak, Stanisław Szmigielski. PS2021 - The noninvasive modulation of the blood stem cell's pool in human: circulating lymphocytes and somatic effects Marat A. Karamullin, Alexey V. Babak, Ludmila P. Ekimova, Vladimir V. Salukhov, Vjacheslav A. Phedorov, Elena B. Kireeva, Anatoly E. Sosukin, Alexey N. Shoutko.

PS2023 - Inhibition of p38 MAPK reduces ionizing radiation (IR)-induced hematopoietic suppression by preventing hematopoietic stem/progenitor cell senescence Yong Wang, Lingbo Liu, Daohong Zhou. PS2024 - Glutamate transporter response after exposure to low-dose gamma and proton radiation

PS2025 - Local radiotherapy induces recruitment of hematopoietic stem cells to the irradiated bone marrow Carlo Bastianutto, Asim Mian, Julie Symes, Joseph Mocanu, Nehad Alajez, Will Shi, Jeff Medin, Armand Keating, Michael Crump, Mark Minden, Mary Gospodarowicz, FeiFei Liu. PS2026 - Evidence for genomic instability in human haemopoietic stem cells containing radiation-induced chromosome aberrations Natalia D. Sumption, Dudley T. Goodhead, Rhona M. Anderson. ______________________________________ PS2.4 - Clinical Therapeutic Radiobiology 2 PS2027 - Possible influence of multiple SNP markers to urological morbidity induced by radiotherapy with carbon-ions among 133 prostate cancer patients Tomo Suga, Mayumi Iwakawa, Shuhei Noda, Hiroshi Tsuji, Eisei Oda, Yoshimi Otsuka, Atsuko Ishikawa, Hirohiko Tsujii, Takashi Imai. PS2028 - Relative biological effectiveness (RBE) of carbon ions in the rat spinal cord Peter Peschke, Christian P. Karger, Michael Scholz, Jürgen Debus, Peter Huber.

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PS2022 - Metabolomics as a tool for understanding the cellular stress response of TK6 cells following ionizing radiation exposure Andrew D. Patterson, Henghong Li, Kristopher W. Krausz, Albert J. Fornace, Jr., Frank J. Gonzalez, Jeffrey R. Idle.

Martha C. Sanchez, Abigail Benitez, Leticia S. Ortloff, Lora M. Green.

PS2029 - Effect of radiation therapy of carbon -ion to Mesothelioma Kumie Nojima, Masao Suzuki, Yoshinobu Harada. PS2030 - Research of boron neutron capture therapy (bnct) for cancer at Kyoto University reactor (kur) Koji Ono, Shin-ichiro Masunaga, Minoru Suzuki, Kenji Nagata, Yuko Kinashi, Akira Maruhashi, Yoshinori Sakurai, Shin-ichi Miyatake, Junich Hiratsuka, Junich Hiratsuka, Itsuro Kato.

PS2032 - 17-allylamino-17demethoxygeldanamycin enhances the cytotoxicity of tumor cells irradiated with carbon ions Miho Noguchi, Dong Yu, Ryoichi Hirayama, Emiko Sekine, Koichi Ando, Ryuichi Okayasu. PS2033 - Characterization of cell death induced by high LET irradiation in head and neck squamous cell carcinomas: implications for future clinical application in hadrontherapy Mira Maalouf, Gersende Alphonse, Michael Beuve, Priscilla BattistonMontagne, Claudia Fournier, Gisela Taucher-Scholtz, Claire RodriguezLafrasse. 56

PS2035 - Elevated expression of Prx1 and Nrf2 in stage I non-small cell lung cancer: Prx1, but not Nrf2, is an independent prognostic factor for disease recurrence and reduced survival after surgery Xiaofei Yu, Joo-Heon Kim, Paul Bogner, Nithya Ramnath, Yoorim Park, Jihnhee Yu, Young-Mee Park. PS2036 - Hypofractionation results in reduced tumor cell kill compared to conventional fractionation for tumors with regions of hypoxia. David J. Carlson, Paul J. Keall, J. Martin Brown. PS2037 - The correlation of intrinsic radiosensitivity with bystander response in individual colorectal carcinoma patients undergoing radiotherapy treatment Orla L. Howe, Jacintha O Sullivan, Blathnaid Nolan, Brenden McClean, Fiona M. Lyng. PS2038 - Relative effectiveness equation of proliferative tumour cells: concept of hyper-extended fractionation: application to lung radiotherapy Rakesh M. Chandola. PS2039 - Tumor carbonic anhydrase 9 expression is associated with the

Tuesday

PS2031 - Gene expression profiling in normal human fibroblasts following the irradiation with heavy ion particles by HIMAC Akira Fujimori, Katsutoshi Suetomi, Ryuichi Okayasu, Sentaro Takahashi.

PS2034 - Hydrogen peroxide enhances radiation-induced apoptosis in the PC-3 prostate cancer cell line Shinji Kariya, Ken Sawada, Toshihiro Kobayashi, Akihito Nishioka, Yasuhiro Ogawa.

presence of lymph node metastases in uterine cervical cancer Hye-Jin Shin, Sun Lee, Jooyoung Kim. PS2040 - Cluster effects within the Local Effect Model - Application to in vitro and in vivo experiments Thilo Elsasser, Michael Scholz.

PS2042 - Radio-sensitization by 17-AAG in insulin growth factor 1 receptor over-expressed tumor cells Dong Yu, Miho Noguchi, Emiko Sekine, Akira Fujimori, Masahiko Miura, Ryuichi Okayasu. PS2043 - Loratadine-mediated enhancement of radiation response Benjamin P. Soule, Nicole L. Simone, William DeGraff, John A. Cook, James B. Mitchell. PS2044 - Potential role for 13-cis-retinoic acid and alpha interferon to increase radiation effectiveness via abrogation of bcl-2 over expression in prostate tumor cells while sparing normal human colonic cells

PS2.5 - DNA Damage 2 PS2045 - TP53 and TP53-related genes associated with protection from apoptosis in the radioadaptive response Ryuji Okazaki, Akira Ootsuyama, Toshiyuki Norimura. PS2046 - A mechanism for the radiosensitizing effect of gold nanoparticles in radiotherapy: the increased generation of secondary electrons around DNA Yi Zheng, Darel Hunting, Leon Sanche, Patrick Ayotte. PS2047 - Effect of thorium and rare earth mixed dust on cytokines and genetics in occupational exposed workers Huimin Lu, Kejun Jia, Cuilan Zhang, Chunyan Wang, Wei Zhang, Hui Zheng, Yufei Liu, Xumin Tu, Shuxia Hao, Rong Zhen, Xu Su. PS2048 - The maximal protection by DMSO in mammalian cells exposed to very high LET radiation Ryoichi Hirayama, Atsushi Ito, Yoshiya Furusawa, Koichi Ando, Masanori Tomita, Teruyo Tsukada, Masako Izumi, Fumio Yatagai, Ryuichi Okayasu. PS2049 - American ginseng reduces micronuclei yield in human lymphocytes after low dose radiation exposure 57

Tuesday

PS2041 - IGF-IR gene expression as a predictor to radiation response in patients with advanced cervical carcinoma Pablo Moreno Acosta, Myriam Sánchez de Gómez, Alejandro García Carrancá, Ricardo Cendales, Jaime Triana, German Dario Díaz, Zoila Conrado, Antonio Huertas, Monica Molano, Maria Mercedes Bravo, Rosalba Ospino, Maria Cristina Plazas.

Colin K. Hill, Grant Dagliyan, Parvesh Kumar. ______________________________________

Wei-Dong Wang, T.K. Lee, H. Mota, R.R. Allison, R.M. Johnke, C. Sibata, A.L. Wiley. PS2050 - Histone H2AX phosphorylation (γ-H2AX) and cell survival following ionizing radiation with thiol containing drugs in human microvascular endothelial cells (HMEC) Yasushi Kataoka, Jeffrey S. Murley, David J. Grdina. PS2051 - Modulation of radiosensitivity in lung cancer cell line by a selenium-metabolizing enzyme Ji Hyun Lee, Su-Jae Lee, Yun-Sil Lee, Sangwoo Bae.

PS2053 - Hypersensitive γH2AX dose response and infrequent apoptosis in normal epidermal skin from radiotherapy patients Martin Simonsson, Fredrik Qvarnstrom, Jan Nyman, Karl-Axel Johansson, Ingela Turesson. PS2054 - γ-H2AX in blood as a biomarker for low dose irradiation exposure Christophe E. Redon, Olga A. Sedelnikova, William M. Bonner. PS2055 - Evaluation of radioprotection of a new chemical entity ON01210 (Ex-RadTM) using alkaline comet assay 58

PS2056 - Hemolytic anemia and iron accumulation in CuZn-superoxide dismutase knockout mice Micael Granstrom, Stefan L. Marklund, Goran Roos. PS2057 - Protection against direct type DNA damage by ligands containing tyrosine and tryptophan Sam Bullick, Jamie Milligan. PS2058 - Hot spot occurrence in a nickel resistance gene (nrp) of Enterobacter sp. Ni15 after a gamma ray irradiation Young-Keun Lee. PS2059 - Comparative studies on spontaneous and ionizing radiation induced mutagenesis between somatic and male germ cells Naoko Shiomi, Katsuko Noshiro, Seiji Kito, Kenichi Masumura, Takehiko Nohmi, Tadahiro Shiomi. PS2060 - Estimation of mutation induction rates in AT-rich sequences using a genome scanning approach following Xirradiation of mouse spermatogonia Jun-ichi Asakawa, Nori Nakamura, Hiroaki Katayama, Harry M. Cullings. PS2061 - Complex mutations in rpoB gene produced from irradiated Bacillus subtilis spores

Tuesday

PS2052 - Ionizing radiation and free radical induced DNA strand breaks: Effects of ion chelator and free radical scavenger Meriyani M. Odyuo, Rajeshwar N. Sharan.

K. S. Kumar, M. W. Perkins, S Ghosh, T-C. Kao, K Hieber, S. Cosenza, MVR Reddy, E. P. Reddy2, M. Maniar, A.A. Alfieri, T. M. Seed.

Nobuo Munakata, Toshiyuki Natsume, Atsushi Kamata, Kotaro Hieda. PS2062 - Effects of particle LET and dose fractionation on tissue-specific mutations in vivo Polly Y. Chang, James Bakke, Angela Puey, Sylvia Lin. PS2063 - Kinetics of CHO AL mutant expression after treatment with radiation, EMS, MNNG and asbestos Stephen B. Keysar, MIchael H. Fox.

PS2.6 - DNA Repair 2 PS2065 - Role of DNA polymerase β in response to ionizing radiation: studies with a dominant negative Sari Neijenhuis, Manon VerwijsJanssen, Gaby Rumping, Kerstin Borgmann, Ulla Kasten-Pisula, Ekkehard Dikomey, Conchita Vens, Adrian Begg. PS2066 - Accelerated formation of colour junctions directly after irradiation by manipulation of homologous recombination with mild hyperthermia Nicolaas A. Franken, Judith W. Bergs, Przemek Krwawczyk, Tony

PS2067 - Development of a nonmammalian vertebrate model system to investigate mechanisms and pathways of genomic instability in vivo Wendy W. Kuhne, Lingling Ding, William S. Dynan. PS2068 - Imaging the direct interaction of Artemis with DNA in irradiated cells Geoffrey E. Brand, Kai Rothkamm, Kevin Prise. PS2069 - Interactions of the c-terminal domain of human ku70 with DNA substrate: a molecular dynamics study Shaowen Hu, Claudio Carra1 Janice L. Huff, Janice M. Pluth, Francis A. Cucinotta. PS2070 - DNA double strand breaks are not sufficient to initiate recruitment of TRF2 Eli S. Williams, Jan Stap, Jeroen Essers, Brian Ponnaiya, Martijn S. Luijsterburg, Przemek M. Krawczyk, Robert L. Ullrich, Jacob A. Aten, Susan M. Bailey. PS2071 - Studies on response to the challenging dose of x-rays in lymphocytes of prostate cancer patients and healthy donors Mateusz Krzysiek, Antonina Cebulska-Wasilewska, Zygmunt Dobrowolski, Agnieszka Panek, Wacław Lipczynski, Barbara Dobrowolska. 59

Tuesday

PS2064 - Germline minisatellite mutation rate in the offspring of radiation workers from Sellafield Nuclear Facility, UK Gwen S. Rees, Laura Guyatt, Patricia A. Jonas, E Janet Tawn, David H. Macgregor. ______________________________________

Cisouw, Jan Stap, Chris van Bree, Jaap Haveman, Jan Paul Medema, Jacob A. Aten.

PS2072 - A structure: function analysis of ku86 Junghun Kweon, Eric A. Hendrickson. PS2073 - Telomeric sister chromatid exchange, DNA repair and aging Robert Hagelstrom, Sandy Chang, Laura Niedernhofer, Susan M. Bailey. PS2074 - Oxidative stress-induced intestinal tumorigenesis in mice with a targeted disruption of the Mutyh gene Teruhisa Tsuzuki, Takuro Isoda, Kazumi Yamauchi, Yusaku Nakabeppu, Yoshimichi Nakatsu.

PS2076 - Deoxycytidyl transferase activity of human REV1 and its substrate specificity Jinlian Piao, Yuji Masuda, Kenji Kamiya. PS2077 - Loss of FANCD2 sensitizes cells to topoisomerase II poisons but does not disrupt non-homologous end-joining Henning Willers, Li Li, Chen-Mei Luo, Jochen Dahm-Daphi, Lisa A. Kachnic. PS2078 - A novel role of DNA repair factor NBS1 in centrosome maintenance 60

PS2079 - The meiosis-specific synaptonemal complex protein SCP3 is expressed in cancer and induces aneuploidy in somatic cells Noriko Hosoya, Sho Hangai, Kiyoshi Miyagawa. PS2080 - Low dose-rate effects and nonhomologous end-joining repair pathway of double strand breaks Hiroshi Utsumi, Kuniyoshi Iwabuchi, Akihisa Takahashi, Akira Tachibana. PS2081 - DNA Double-strand break repair in vivo assessed by gamma-H2AX in blood lymphocytes and normal tissues of repair-proficient and deficient mouse strains Martin Kuhne, Nicole Rief, Xiaorong Dong, Saskia Grudzenski, Christian Rübe, Markus Lobrich, Claudia E. Rube. PS2082 - Measurements of DNA-double strand breaks after tumour therapy-related carbon irradiation and comparison with γH2AX analysis after induction of highly complex DNA-lesions Yvonne Eva Schweinfurth, Jana Topsch, Philippe Barberet, Burkhard Jakob, Gisela Taucher-Scholz. PS2083 - Functional interaction between histone H2AX and NBS1 on ATMdependent DNA damage response Junya Kobayashi, Hiroshi Tauchi, Shinya Matsuura, David Chen, Kenshi Komatsu.

Tuesday

PS2075 - Characterization of a human DNA helicase, PIF1, which is responsible for chromosomal integrity Yongqing Gu, Yuji Masuda, Kenji Kamiya.

Mikio Shimada, Junya Kobayashi, Kenshi Komatsu.

PS2084 - Homologous recombination repair is regulated by domains at the N- and C-terminus of NBS1 and is dissociated with ATM functions Kyosuke Nakamura, Syuichi Sakamoto, Kenta Iijima, Daisuke Mochizuki, Keisuke Teshigawara, Junya Kobayashi, Shinya Matsuura, Hiroshi Tauchi, Kenshi Komatsu.

PS2087 - Late phase activation of ATM and DNA-PKcs kinases upon UVinduced replication stress Hirohiko Yajima, Kyung-Jong Lee, Benjamin P.C. Chen. PS2088 - The mechanism of DNA-PKcs regulating the phosphorylation of H2AX Jing An, Qin-Zhi Xu, Jian-Li Sui, Bei Bai, Ping-Kun Zhou. ______________________________________

PS2089 - Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway Konjeti R. Sekhar, Vijayakumar N. Sonar, Venkatraj Muthusamy, Andrei Laszlo, Jamil Sawani, Nobuo Horikoshi, Ryuji Higashikubo, Robert G. Bristow, Peter A. Crooks, Joseph L. Roti Roti, Michael L. Freeman. PS2090 - Inhibition of repair of radiationinduced damage by mild hyperthermia with reference to the effect on quiescent cells in solid tumors Shin-ichiro Masunaga, Kenji Nagata, Minoru Suzuki, Genro Kashino, Yuko Kinashi, Koji Ono. PS2091 - The anti-tumor effects of cisplatin-TSL with hyperthermia (HT) and radiation therapy (RT) in a human colorectal cancer xenograft Jessica A. Tashjian, Eric A. Lee, Benjamin L. Viglianti, Yulin Zhao, Ana M. Ponce, Bruce Bondurant, Mark W. Dewhirst. PS2092 - Localized hyperthermia combined with intratumoral dendritic cells induces systemic antitumor immunity Arunika Mukhopadhaya, Joseph Mendecki, XinYuan Dong, Alan A. Alfieri, Laibin Liu, Shalom Kalnicki, Madhur Garg, Chandan Guha.

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Tuesday

PS2085 - Inhibition of ATM may induce high frequency of misrepair in normal and AT heterozygous fibroblast cells Tetsuya Kawata, Francis Cucinotta, Kerry George, Naoyuki Shigematsu, Masayoshi Saito, Kouhei Inoue, Cuihua Liu, Hisao Ito. PS2086 - The Complexity of Phosphorylated H2AX foci and DNA repair proteins at ionizing radiation induced DNA doublestrand breaks in mammalian cells Asako Nakamura, William M. Bonner.

PS2.7 - Experimental Therapeutics 2

PS2093 - Increased granulocyte recovery from radiation exposure following mild hyperthermia Thomas Mace, Maegan Capitano, Adrienne Kisailus, Wainwright Jaggernauth, Elizabeth Repasky. PS2094 - Selective inhibition of cyclooxygenase-2 and activation of adenosine membrane receptors two new promising approaches for treatment of radiation-induced myelosuppression Michal Hofer, Milan Pospíšil, Antonín Vacek, Jiřina Holá, Denisa Štreitová, Vladimír Znojil.

PS2096 - Oxidative stress and acetylcholinesterase activation in the brain after thorium administration in swiss mice Amit Kumar, Badri Narain Pandey, Kaushala Prasad Mishra. PS2097 - Chronic administration of the angiotensin II type 1 receptor antagonist (AT1RA) L158, 809 prevents radiation-induced cognitive impairment Weiling Zhao, Valerie Payne, Mitra Kooshki, David Riddle, Judy Brunso-Bechtold, Mike Robbins. PS2098 - Growth hormone protects against lethal irradiation 62

PS2099 - Redox modulation of oxidative stress by Mn porphyrin-based radioprotectors/anticancer therapeutics. The effect of charge distribution Júlio S. Rebouças, Ivan Spasojević, Ludmil Benov, Daryono H. Tajhjono, Ines Batinić-Haberle. PS2100 - Potent radioprotector/anticancer drug MnTE-2-PyP5+: its pharmacokinetics and subcellular distribution Ivan Spasojević, Lichun Zhang, Yumin Chen, Teresa J. Noel, Marsha P. Cole, Yunfeng Zhao, Júlio S. Rebouças, Daret St. Clair, Ines Batinic-Haberle. PS2101 - Dose-dependent effects of cranial cesium irradiation on cognition in c57bl6/j mice Laura Villasana, Ken A. Jenrow, Steve L. Brown, Jae Ho Kim, Jacob Raber. PS2102 - Gender-related differences in radiation cataractogenesis Mark A. Henderson, Shailaja Valluri, Colleen DesRosiers, Jennifer T. Lopez, Christopher N. Batuello, Andrea Caperell-Grant, Marc S. Mendonca, Eva-Marie Powers, Robert M. Bigsby, Joseph R. Dynlacht. PS2103 - Prophylactic effect of flaxseed oil against radiation-induced hepatotoxicity in mice Arvind L. Bhatia.

Tuesday

PS2095 - Experimental studies of intestine damage caused by combined radiation-burn injury with chitosan DNA nanoparticles of [Gly2]GLP-2 and HD-5 Ai Guoping, Su Yongping, Tan Hu.

Benny J. Chen, Divino DeOliveria, Nelson J. Chao.

PS2104 - Comparison between photodynamic and sonodynamic cytotoxicities in vitro Jhony EL Maalouf, Jean Louis Mestas, Laurent Alberti, Sabrina Chesnais, Jean Paul Steghens, Cathignol Dominique. PS2105 - Effect of epothilone B and radiation in Chinese hamster cells Shungjun Yang, Mingliang Jiang, Hani Ashamalla.

PS2110 - FDG-PET predicts sensitivity of human head and neck cancer xenografts to cisplatin combined with 2-deoxy-D-glucose Andrean L. Simons, David M. Mattson, Melissa A. Fath, Susan A. Walsh, Brian J. Smith, Richard D. Hichwa, Michael M. Graham, Kenneth J. Dornfeld, Douglas R. Spitz. ______________________________________ PS2.8 - Physics/Chemistry 2

PS2107 - Chemosensitization by 2-deoxyD-glucose in multicellular tumor spheroids results from the multiple death pathways stimulated by a combination of endogenous and induced oxidative stress Divya Khaitan, Sudhir Chandna, Bilikere S. Dwarakanath. PS2108 - Chemoradiosensitization of a novel camptothecin derivative Ge Huang, Huijuan Wang, Li-xi Yang. PS2109 - Intra-tumoral delivery of radiolabelled iododeoxyuridine Shirley Lehnert, Abraham Owusu, Yongbiao Li, Edward Bump, Bill Riddoch.

PS2111 - On the chemical yield of base lesions, strand breaks, and clustered damage generated in plasmid DNA by the direct effect of X-rays William A. Bernhard, Shubhadeep Purkayastha, Jamie R. Milligan. PS2112 - Measurement of hydroxyl radicals and 8hydroxydeoxyguanosine induced by high-LET heavy-ion irradiation Takashi Moritake, Kazunori Anzai, Kailash Manda, Megumi Ueno, Mitsuko Takusagawa, Mayumi Iwakawa, Takashi Imai. PS2113 - Deoxyribose damage is sensitive to base sequence context and end effects: the release of unaltered free base from oligodeoxynucleotides films by the direct effect of ionizing radiation Kiarn K. Sharma, William A. Bernhard. PS2114 - Photo-excitation of one-electron oxidized RNA nucleosides and 63

Tuesday

PS2106 - Enhancement of somatostatinreceptor targeted radionuclide therapy by gemcitabine pretreatment mediated receptor upregulation and cell cycle modulations Tapan K. Nayak, Eric R. Prossnitz, Robert W. Atcher, Jeffrey P. Norenberg.

rna-oligomers in the near uv-vis region produces sugar radicals Amitava Adhikary, Sean Collins, Deepti Khanduri, David Becker, Michael D. Sevilla. PS2115 - An improved analytic description of the Bethe surface of liquid water: application to inelastic and stopping cross section calculations for low-energy electrons Dimitris Emfietzoglou, Isabel Abril, Rafael Garcia-Molina, Anand Pathak, Hooshang Nikjoo.

PS2117 - Effects of microscopic target structures on local dose distributions Jacob A. Gersh, Michael Dingfelder, Larry H. Toburen. PS2118 - On OH radicals in water under heavy ion irradiation Mitsumasa Taguchi, Atsushi Kimura, Gérard Baldacchino, Yosuke Katsumura, Koichi Hirota. PS2119 - Proton induced electron emission spectra from condensed phase targets R. A. McLawhorn, S. L. McLawhorn, G. W. Kalmus, L. H. Toburen, E. L. B. Justiniano, J. L. Shinpaugh.

64

PS2121 - A study of anomalous behavior of radon in groundwater and soil gas for earthquake prediction Sandeep Mahajan. PS2122 - A novel analytical approach for estimating terrestrial cosmic-ray dose for anywhere in the world Tatsuhiko Sato, Hiroshi Yasuda, Koji Niita, Akira Endo, Lembit Sihver. PS2123 - Assessment of space radiation risk for future lunar missions Myung-Hee Y. Kim, Artem Ponomarev, Bill Atwell, Francis Cucinotta. PS2124 - Verification of the PHITS-based analytical model in application to dosimetry of cosmic radiation exposure in aircraft Hiroshi Yasuda, Tatsuhiko Sato, Masashi Takada, Takashi Nakamura. ______________________________________ PS2.9 - Radiation Carcinogenesis 2 PS2125 - Modulation of the growth of pulmonary tumor colonies in mice after single or fractionated lowlevel irradiations with X-rays Jolanta Wrembel-Wargocka, Ewa M. Nowosielska, Aneta Cheda, Marek K. Janiak.

Tuesday

PS2116 - An object oriented trackstructure code for simulations of energy depositions from light ions Kristin Wiklund, Anders Brahme, Bengt K. Lind.

PS2120 - Foliar absorption pathway and use efficiency of 45Ca and 32P radioisotope tracer technique on sweet persimmon Md. Belal N. Hossain.

PS2126 - Enzymatic alterations in rats’ brain exposed to low level microwave radiation Paulraj Rajamani, Jitendra Behari. PS2127 - Activation of interleulin-9 receptor and downstream STAT3/5 in primary T-lymphomas in vivo in susceptible B6 and resistant C3H mouse Yi Shang, Shizuko Kakinuma, Yoshiko Amasaki, Mayumi Nishimura, Yoshiro Kobayashi, Yoshiya Shimada.

PS2129 - Reduction of the background mutation by a low dose Xirradiation of Drosophila spermatocytes at a low dose-rate Takao Koana, Mikie O. Okada, Keiji Ogura. PS2130 - Influence of p53 on the induction of mouse skin tumors by repetitive beta-irradiation Akira Ootsuyama, Ryuji Okazaki, Toshiyuki Norimura. PS2131 - High relative biological effectiveness of carbon ion radiation on induction of rat

PS2132 - Combined effects of ionizing radiation and N-ethyl-Nnitrosourea in murine thymic lymphoma Shizuko Kakinuma, Yoshiko Amasaki, Kazumi Yamauchi, Mayumi Nishimura, Tatsuhiko Imaoka, Yoshiya Shimada. PS2133 - Effect of simultaneous of X-rays and N-ethyl-N-nitrosourea on lymphomagenesis in B6C3F1 mice Yoshiko Amasaki, Shinobu Hirano, Shizuko Kakinuma, Kazumi Yamauchi, Mayumi Nishimura, Tatsuhiko Imaoka, Yoshiro Kobayashi, Yoshiya Shimada. PS2134 - Promoter methylation of Slc family genes in rat mammary tumors induced by gamma rays or carbon ions Mayumi Nishimura, Tatsuhiko Imaoka, Shizuko Kakinuma, Yu Yamaguchi, Yasushi Ohmachi, Satoshi Yamashita, Toshikazu Ushijima, Yoshiya Shimada. PS2135 - Methylation of SOCS3 and p15 in carbon-ion-induced thymic lymphomas of B6C3F1 mice Yoshiya Shimada, Shigeko Ebishima, Yu Yamaguchi, Yoshikazu Kuwahara, Shizuko Kakinuma, Yoshiko Amasaki, 65

Tuesday

PS2128 - Dose and dose rate dependency in radiation-induced mutation in liver and spleen of gpt-delta mice Tetsuya Ono, Naohito Okudaira, Yoshihiko Uehara, Tsuneya Matsumoto, Youichi Oghiso, Kimio Tanaka, Kazuaki Ichinohe, Shingo Nakamura, Satoshi Tanaka, Nao Kagawa, Kazuo Fujikawa, Akira Ootsuyama, Toshiyuki Norimura, Takehiko Nohmi.

mammary carcinoma and its lack of H-ras and Tp53 mutations Tatsuhiko Imaoka, Mayumi Nishimura, Shizuko Kakinuma, Yukiko Hatano, Yasushi Ohmachi, Akihiro Kawano, Akihiko Maekawa, Yoshiya Shimada.

Mayumi Nishimura, Tatsuhiko Imaoka, Yoshiro Kobayashi, Yuichi Sato. ______________________________________ PS2.10 - Radioprotectors/Mitigators 2 PS2136 - Radioprotection effect and antitumor immunity by yeast-derived β-glucan in mice Yeunhwa Gu. PS2137 -Polydrug: A novel concept for mitigation of radiation injury Mukut Sharma.

PS2139 - A novel somatostatin analogue, SOM230 (pasireotide), increases survival after total body irradiation Qiang Fu, Herbert Schmid, Marjan Boerma, Xiaohua Qiu, Junru Wang, Martin Hauer-Jensen. PS2140 - Influence of endothelin-1 receptor inhibition on functional, structural and molecular changes in the rat heart after irradiation Marjan Boerma, Junru Wang, Ashwini Kulkarni, Kerrey A. Roberto, Xiaohua Qiu, Martin Hauer-Jensen. PS2141 - Heat-killed mineral yeast as a potent post-irradiation radioprotector 66

PS2142 - Phosphorylation and subcellular localization of MAPK p38 in the bone marrow cells irradiated in vivo and the role of amifostine in these processes Helena R. Segreto, Celina T. Oshima, Maria Regina R. Silva, Mizue I. Egami, Priscilla B. Carvalho, Vicente P. Teixeira, Roberto A. Segreto. PS2143 - Protective effects of a new herbal composition (HemoHIM) against a gamma-radiation and anticancer drugs Sung-Kee Jo, Hae-Ran Park, Uhee Jung, Sung-Ho Kim, Sung-Tae Yee. PS2144 - Histone deacetylase inhibitors reduce lethality following total body irradiation Jae Ho Kim. PS2145 - Radioprotective effects of recombinant human epidermal growth factor (rhEGF) in C3H/HeJ mice Hae Jin Oh, Won Woo Kim, Sook In Chung, Jinsil Seong. PS2146 - Keratinocyte growth factor (Palifermin) accelerates the radiation-induced up-regulation of integrin linked kinase in oral mucosa (mouse) during daily fractionated irradiation Bettina Habelt, Margret Kuschel, Wolfgang Doerr.

Tuesday

PS2138 - Recombinant human epidermal growth factor accelerate the proliferation and migration of the irradiated human fibroblasts in vitro Sang-wook Lee, Soo Young Moon, Eun Kyung Choi.

Kazunori Anzai, Nobuo Ikota, Megumi Ueno, Minako Nyuui, Makoto Akashi, Tsutomu V. Kagiya.

PS2147 - Mitochondrial targeting of a catalase transgene product further increases radioresistance induced by MnSOD overexpression in 32Dcl3 murine hematopoietic progenitor cells Michael W. Epperly, J Andres Melendez, Xichen Zhang, Darcy Franicola, Tracy Smith, Joel S. Greenberger. PS2148 - Radioprotective mechanisms by a new chemical entity ON01210 (Ex-RadTM) in HUVEC cells Sanchita P. Ghosh, Michael W. Perkins, Kevin Hieber, Stephen C. Cosenza, M.V. Ramana Reddy, E. Premkumar Reddy, Manoj Maniar, Alan Alfieri, Thomas Seed, K. Sree Kumar.

PS2150 - The role of gap junctions on irradiated htori3-llu cells +/radioprotector Virginia G. Serra, Leticia Ortloff, Pinal Pandya, Anil Kulkarni, Lora Green. PS2151 - Synthetic FGF2 peptide mitigates gastrointestinal radiation damage Lurong Zhang, Weimin Sun, Louis Pena, Jianjun Wang, Shanmin Yang, Shanmin Yang, Hengshan Zhang, Wei Wang, Mei Zhang, Chaomei Liu, Paul Okunieff.

PS2153 - Radioprotective effect of hypothermia on the blood system cells in mammals Andrei V. Rodionov. PS2154 - Radiation protection by toll like receptors (TLR) ligands and small molecules Damodar Gupta, Andrei Gudkov. ______________________________________ PS2.11 - Signaling 2 PS2155 - Postirradiation dynamism of intratumoral HIF-1 activity; Balance of degradation and hypertranslation of HIF-1α protein Hiroshi Harada, Satoshi Itasaka, Shinae Kondoh, Masahiro Hiraoka. PS2156 - Cytotoxic and cytoprotective signaling pathways mediated by reactive oxygen and nitrogen species Takanori Katsube, Masahiko Mori, Hideo Tsuji, Tadahiro Shiomi, Makoto Onoda. PS2157 - Radiation-induced oxidative stress in lungs of mice knocked-out

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Tuesday

PS2149 - Carbon monoxide protects the immature mouse hippocampus from radiation-induced apoptosis Glenn T. Gobbel, Kotaro Nakaya, Sait Sirin, Leo E. Otterbein, John C. Flickinger.

PS2152 - Single injection of novel radioprotectant CBLB502 significantly increases survival of lethally irradiated non-human primates Vadim Krivokrysenko, Farrel Fort, Eugenia Strom, Andrei Osterman, Ludmila Burdelya, Thomas Tallant, Natalia Tararova, Ratan Maitra, Joseph DiDonato, Andrei Gudkov, Elena Feinstein.

for genes involved in inflammatory processes Carine Laurent, Wen-Chen Yeh, Richard P. Hill. PS2158 - Gene expression profiles of MCF-7 cells under hypoxic condition Chin-yu Lin, Mong-Hsun Tsai, William DeGraff, James B. Mitchell, Eric Y. Chuang. PS2159 - Regulation of mRNA translation is a major contributor to hypoxia regulated gene expression Twan van den Beucken, Marianne Koritzinsky, Michael Magagnin, Renaud Seigneuric, Philippe Lambin, Bradly G. Wouters.

PS2161 - TRC8 regulates the chromosomal passenger protein, survivin. A potential role in hypoxia/reperfusion-induced G2 arrest and chromosome integrity Md Ashraful Islam, Wayne S. Zundel. PS2162 - Role of the Mitochondria-K Channel Axis in the Response of Glioblastoma Cell Lines to Hypoxia Jason M. Derry, Joan AllalunisTurner. +

68

PS2164 - Reactive oxygen species modulate CDK4/cyclinD1 in differentiation of PLB-985 cells Wakako Hiraoka, Yoshihiro Ando. PS2165 - Assessment of hypoxia after pulmonary irradiation in rats with exogenous and endogenous hypoxia markers (EF5, CA9, HIF1α) Katharina C. Fleckenstein, Benjamin M. Gauter-Fleckenstein, Zahid Rabbani, Thies Schroeder, Zeljko Vujaskovic. PS2166 - ATM-dependent signaling in response to ionizing radiation - a proteomic approach Amrita K. Cheema, Sung A. Lee, Lihua Zhang, Rency Verghese, Habtom Ressom, Anatoly Dritschilo, Mira Jung. PS2167 - Mechanisms of ATM regulation by TGFβ Jenny Paupert, Mary-Helen Barcellos-Hoff. PS2168 - ATM, MOF and DNA repair Tej K. Pandita. PS2169 - Persisted formation of phosphorylated ATM and 53BP1 foci and radiation induced permanent cell cycle arrest examined by single-cell based assay

Tuesday

PS2160 - Activation of HIF-1 after mild hyperthermia and its downstream effect on tumor angiogenesis and metabolism Eui Jung Moon, Ines BatinicHaberle, Mark W. Dewhirst.

PS2163 - NADPH oxidase mediates radiation-induced oxidative stress and inflammation in brain endothelium J Racquel Collins-Underwood, Weiling Zhao, Mike E. Robbins.

Yasuyoshi Oka, Keiji Suzuki, Masao Tomonaga. PS2170 - ATM/NF-κB-mediated adaptive radioresistanace in human keratinocytes Kazi Mokim Ahmed, Ming Fan, Danupon Nantajit, Junran Zhang, Jian Jian Li. PS2171 - The γ-ray irradiation induced lyGDI cleavage, cell apoptosis and its nuclear signal function Xinwen Zhou, Shiho Suto, Fumio Suzuki, T Ota.

PS2173 - Survivin expression is not altered during UV-B induced apoptosis in SCL-II cells Ralf Kriehuber, Marcus Unverricht, Nicole Busch, Dieter G. Weiss. PS2174 - Protein serine/threonine phosphatase type 2a regulates IRinduced apoptosis James M. Larner, Jun Mi. PS2175 - The DNA repair protein Nbs1 suppresses ionizing radiationinduced apoptosis Friederike Eckardt-Schupp, Daniel Sagan, Simone Moertl, Hedda Eichholtz-Wirth. ______________________________________

PS2176 - Possible role of synergistic interaction of ionizing radiation with other detrimental agents for radiation accident consequences Vladislav G. Petin, Jin Kyu Kim. PS2177 - Ionising radiation exposure of the eyes of patients during X-ray examinations Jaroslaw Jazwinski, Maria A. Staniszewska, Agnieszka Kowalska, Magdalena Zabicka, Radoslaw Rozycki, Ewa M. Nowosielska, Marek K. Janiak. PS2178 - Modeling effects of atomic bomb radiation on disease outcomes with radiation-influenced risk factors Lori A. Williams, Wan-Ling Hsu, Kenneth J. Kopecky. PS2179 - An “Effective functional subunit size” model for the dose response of rat spinal cord paralysis Magdalena Adamus-Górka, Panayiotis Mavroidis, Anders Brahme, Bengt K. Lind. PS2180 - PRIME I: a phase III randomised trial assessing the impact of adjuvant breast radiotherapy on quality of life in low risk older patients following breast conserving surgery Ian H. Kunkler, Robin J. Prescott, Linda J. Williams, Celia C. King.

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Tuesday

PS2172 - Role of Bcl-2/Bax ratio in predicting radiotherapy response in patients with local advanced non-small lung cancer Wei-Dong Wang, Rong Li, Zhengtang Chen.

PS2.12 - Technical Advances/ Imaging/Models 2

Wednesday, July 11, 2007 7:30am - 8:15am Eye Openers

8:30am - 9:30am Congress Lectures

EO 9: Integration of data for systems biology Salon 7 Yerba Buena Michelle Buchanan, Oak Ridge National Lab, Oak Ridge, USA Chair: James Brown, Stanford University, Stanford, USA ______________________________________

CL 13: Systems approach to predicting response to anticancer agents Salon 7 Yerba Buena Joe W. Gray Lawrence Berkeley National Lab, Berkeley, USA Chair: Mary Helen Barcellos-Hoff, Lawrence Berkeley National Lab, Berkeley, USA ______________________________________

EO 10: New mechanistic approaches to modeling radiation-induced cancer Salons 1, 2, 3 Yerba Buena Herwig Paretzke, GSF-National Research Center for Environment and Health, Neuherberg, Germany Chair: Dudley Goodhead, Medical Research Council, Oxfordshire, UK ______________________________________

EO 12: Novel radioprotectors Salon 8 Yerba Buena Roger Martin, Peter MacCallum Cancer Institute, Melbourne, Australia Chair: Jacqueline Williams, University of Rochester, Rochester, USA ______________________________________

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CL 15: Combining radiotherapy and immunotherapy: a revived partnership Salons 10, 11 Yerba Buena Silvia C. Formenti, New York University, New York, USA Chair: Kathy Mason, University of Texas MD Anderson Cancer Center, Houston, USA ______________________________________

Wednesday

EO 11: The silent treatment: delivering RNA interference Salons 4, 5, 6 Yerba Buena Judy Lieberman, Harvard University, Boston, USA Chair: Amy Kronenberg, Lawrence Berkeley National Lab, Berkeley, USA ______________________________________

CL 14: Early epigenetic and genetic events in carcinogenesis Salon 8 Yerba Buena Thea Tlsty, University of California, San Francisco, San Francisco, USA Chair: Tracy Criswell, Case Western Reserve University, Cleveland, USA ______________________________________

CL 16: From cellular to high-throughput predictive assays: going nowhere faster? Salons 1, 2, 3 Yerba Buena Soren Bentzen, University of Wisconsin, Madison, USA Chair: Mitchell Anscher, Virginia Commonwealth University, Richmond, USA ______________________________________ CL 17: Stem cell therapy to reduce radiation-induced normal tissue damage Salons 4, 5, 6 Yerba Buena Robert P. Coppes, University of Groningen, Groningen, The Netherlands Chair: Richard Hill, Ontario Cancer Institute, Toronto, Canada ______________________________________ 8:30am - 9:30am Award Lectures

Michael Fry Award Lecture Telomeres and double-strand breaks: all's well that ends well... Susan M. Bailey, Colorado State University, Fort Collins, USA Marie Curie Award Lecture Excited states enhance DNA and RNA radiation Damage: excitation of guanine cation radicals produce sugar radicals Amitava Adhikary, Oakland University, Rochester, USA

S 23: Genome Wide Approaches to Predicting DNA Damage Response from Yeast to Man Salon 7 Yerba Buena Chairs: Martin Brown, Stanford University, Stanford, USA Noelle Metting, Department of Energy, Washington DC, USA 10:00 - Genome-wide screen of genes affecting response from yeast to radiation James Brown, Stanford University, Stanford, USA 10:30 - Genome-wide analysis of DNA damage responses in C. elegans Marcel Tijsterman, Center for Biomedical Genetics, Utrecht, The Netherlands 11:00 - Computational modeling of signaling systems in cancer Paul Spellman, Lawrence Berkeley National Laboratory, Berkeley, USA ______________________________________ S 24: Radiation Damage and Electron Transfer in Nano-Materials Salon 15 Yerba Buena Chair: John Miller, Brookhaven National Laboratory, Upton, USA 10:00 - Radiation effect on carbon nanotubes in aqueous system Jing Peng, Peking University, Beijing, China

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Wednesday

CL 18: Radiation Research Society, Fry and Curie Award Lectures Salons 12, 13 Yerba Buena Chairs: William McBride, University of California, Los Angeles, Los Angeles, USA Mark Dewhirst, Duke University, Durham, USA

10:00am - 12:00pm Symposia

10:25 - Barrier-controlled hole transfer in duplex DNA in aqueous solution Robert Anderson, University of Auckland, Auckland, NZ 10:50 - Nucleation, growth and properties of metal clusters studied by radiation chemistry Jacqueline Belloni, Université Paris-Sud, Orsay, France 11:15 - Radiation induced redox catalysis on naked metallic particles Dan Meisel, University of Notre Dame, Notre Dame, USA 11:40 - Charge transfer in molecular wires John Miller, Brookhaven National Laboratory, Upton, USA ______________________________________ S 25: Pathways Impacting RadiationInduced Cell Death Salons 10, 11 Yerba Buena Chairs: Michael Freeman, Vanderbilt University, Nashville, USA Y-M Park, Roswell Park Cancer Institute, Buffalo, USA

10:30 - Prx 1 in radiation-induced cell death Young-Mee Park, Roswell Park Cancer Institute, Buffalo, USA 11:00 - Insights on cell death following radiation exposure Kevin Prise, Queen’s University, Belfast, UK 72

10:00 - Immune cells in the tumor microenvironment: friend or foe? Theresa Whiteside, University of Pittsburg, Pittsburg, USA 10:30 - Irradiated tumors recruit immune cells Sandra Demaria, New York University, New York, USA 11:00 - Radiation and immunity in the tumor microenvironment: role of cytokines Edith Lord, University of Rochester, Rochester, New York, USA 11:30 - Radiation affects on the composition and function of immune cells within the tumor microenvironment William McBride, University of California, Los Angeles, Los Angeles, USA ______________________________________ S 27: Approaching the Holy Grail: Predicting Normal Tissue Sensitivity Salons 1, 2, 3 Yerba Buena Chair: Lester Peters, Peter MacCallum Cancer Institute, Melbourne, Australia

Wednesday

10:00 - Insights on cell death following radiation exposure Kathryn Held, Massachusetts General Hospital, Boston, USA

11:30 - Regulation of radiation-induced cell death by PKC-delta Yun-Sil Lee, Korea Institute of Radiological & Medical Sciences, Seoul, Korea ______________________________________ S 26: RRS Presidential Symposium: The Tumor Microenvironment, Immunity, and Radiation Salon 8 Yerba Buena Chair: William McBride, University of California, Los Angeles, Los Angeles, USA

Introduction Lester Peters, Peter MacCallum Cancer Institute, Melbourne, Australia 10:00 - Can individual risk of adverse radiotherapy effects be predicted from genetic profiles? Christian Andreassen, Aarhus University Hospital, Aahus, Denmark 10:30 - Need for large bio/outcome databanks to predict normal tissue radiosensitivity - the GENEPIENTB project Tobias Holscher, University of Dresden, Dresden, Germany 11:00 - Multiple genetic variants associated with risk for adverse skin reactions following radiotherapy in breast cancer patients Takashi Imai, National Institute of Radiological Sciences, Chiba, Japan

S 28: Normal Tissue Cells and Regenerative Medicine Salons 4, 5, 6 Yerba Buena Chair: John R. Fike, University of California, San Francisco, San Francisco, USA

10:30 - Microenvironmental factors impact the radiation response of neural precursor cells John Fike, University of California, San Francisco, San Francisco, USA 11:00 - Radiosensitivity of human epidermal stem cells Michelle Martin, Commissariat à l’Énergie Atomique, Evry, France 11:30 - Ionizing irradiation effects on the stem cell microenvironment Joel Greenberger, University of Pittsburg, Pittsburg, USA ______________________________________ 12:00pm – 1:00pm Plenary Lecture PL 4: Systems biology applied to the DNA damage checkpoint Salon 9 Yerba Buena Stephen J. Elledge, Harvard University, Boston, USA Chair: Kathryn Held, Massachusetts General Hospital, Boston, USA ______________________________________ 2:00pm - 4:00pm Symposia S 29: Microbeam Facilities for Low Dose and Low Dose Rate Investigations Salon 15 Yerba Buena Chairs: Silvia Gerardi, INFN, Padova, Italy Melvyn Folkard, Gray Cancer Institute, Northwood, UK 73

Wednesday

11:30 - Screening radiosensitive patients cells for functional defects Michael McKay, Peter MacCallum Cancer Institute, Melbourne, Australia ______________________________________

10:00 - Hematopoietic stem cell survival after high-dose total body irradiation George Georges, Fred Hutchinson Cancer Research Center, Seattle, USA

2:00 - Electron microbeam studies of radiation induced bystander effects and adaptive responses Marianne Sowa, Pacific Northwest National Laboratory, Richland, USA

3:30 - NCI’s commitment to translational research Ernest Hawk, National Institutes of Health, Bethesda, USA ______________________________________

2:30 - Photon microbeam Melvyn Folkard, Gray Cancer Institute, Northwood, UK

S 31: Cutting Edge Mitigation Treatments Salon 8 Yerba Buena Chairs: Jacqueline Williams, University of Rochester, Rochester, USA Chris Kalman, Astley Ainslie Hospital, Edinburgh, UK

3:00 - Imaging modes with the Columbia University microbeam Alan Bigelow, Columbia University, New York, USA 3:30 - Ion microbeam Silvia Gerardi, INFN, Padova, Italy ______________________________________

Introduction Shigenobu Nagataki, Japan Radioisotope Association, Tokyo, Japan 2:00 - Advances in the treatment of whole body irradiation Patrick Gourmelon, Institut de Radioprotection et de Sûreté Nucléaire, Fontenay aux Roses, France

2:00 - Technology transfer in academia Ken Porter, University of Colorado, Boulder, USA

2:30 - Eating your way out of radiation late effects injury Jennifer Lemon, McMaster University, Hamilton, Canada

2:30 - Medical device industry perspective on collaborations with academia Richard Morse, Calypso Medical Technologies, Seattle, USA

3:00 - New aspects in pathophysiology and treatments following radiation exposure Viktor Meineke, Federal Armed Forces Medical Academy, Munich, Germany

3:00 - Pharmaceutical industry perspective on collaborations with academia Dai Chaplin, Oxigene, Oxford, UK

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3:30 - Cytokines and radiation treatment: mitigators or mitigating targets? Jacqueline Williams, University of Rochester, Rochester, USA

Wednesday

S 30: Industry/Academic Collaborations: The Ins and Outs Salons 1, 2, 3 Yerba Buena Chairs: Robert Sutherland, Varian Biosynergy, Mountain View, USA Robert Radinsky, Amgen, Thousand Oaks, USA

S 32: Space Radiation: What We Know and What We Need to Know Salons 10, 11 Yerba Buena Chairs: Francis Cucinotta, NASA, Johnson Space Center, Houston, USA Amy Kronenberg, Lawrence Berkeley National Laboratory, Berkeley, USA 2:00 - DNA radical signatures of heavy ion track structure Mike Sevilla, Oakland University, Rochester, USA 2:30 - DNA damage and repair in mammalian cells following exposure to heavy ions in the presence or absence of shielding Antonella Tabocchini, Instituto Superiore di Sanita, Rome, Italy 3:00 - Charged particle-induced mutagensis and genomic instability in vitro and vivo Amy Kronenberg, Lawrence Berkeley National Laboratory, Berkeley, USA

2:00pm - 4:00pm Workshops Use of Gene Expression to Predict Response in the Clinic Salon 7 Yerba Buena Chairs: Adrian C. Begg, Netherlands Cancer Institute, Amsterdam, The Netherlands Sally Amundson, Columbia University, New York, USA ______________________________________ W 4:

Controversies and Issues in Radiation Cytogenetics Salons 12, 13 Yerba Buena Chairs: Joel Bedford, Colorado State University, Fort Collins, USA Michael Cornforth, University of Texas Medical Branch, Galveston, USA ______________________________________ 4:00pm Poster Session 3 W 6:

_________________________________________________________

5:45pm - 6:30pm Bacq & Alex Award Lecture (ERRS) Salon 9 Yerba Buena From "DNA depolymerization" to systems radiobiology - evolution of the concept of intrinsic radiation sensitivity Irena Szumiel, Institute of Nuclear Chemistry & Technology, Warsaw, Poland ______________________________________ 6:30pm - 7:15pm Gray Medal Lecture (ICRU) Salon 9 Yerba Buena Some characteristics of biological damage induced by ionizing radiations Eric Hall, Columbia University, New York, USA _________________________________________________________

7:30pm Awards Reception San Francisco Museum of Modern Art 75

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3:30 - Charged particle radiation effects in neural cells and tissues Charles Limoli, University of California, Irvine, Irvine, USA ______________________________________

Temporal Dynamics of DNA Damage Response in Mammalian Cells Salons 4, 5, 6 Yerba Buena Chairs: David Chen, University of Texas Southwestern, Dallas, USA Michael Weinfeld, Cross Cancer Institute, Edmonton, Canada W 5:

ERRS Bacq and Alexander Award The Bacq and Alexander Award was established by the European Radiation Research Society in 1996 to honor an outstanding European researcher in the field of radiation research. It honors the memory of Professors Zenon Bacq and Peter Alexander

who

performed

pioneering

studies

of

basic

radiobiology and of sulfhydryl containing radioprotectors in the 1950’s and 1960’s. Their classic textbook graced the bookshelves of most young radiation investigators for many years. This year’s recipient of the award is Professor Irena Szumiel of Institute of Nuclear Chemistry and Technology, Warsaw, Poland. She is honored for her work on the mechanisms of the effects of radiation, particularly the influence of iron and copper ions in the Fenton reaction that generates OH radicals and the role of cellular signaling involving calcium ions and protein kinase C activity in the development of the adaptive response. She started her scientific career as biochemist at the Warsaw University where she obtained her PhD degree in 1965. Professor Szumiel obtained her DSc degree in 1978; she is author or co-author of

obtained two awards from the National Council for Atomic Energy for studies in the field of radiobiology and five awards from the Polish Association for Radiation Research for studies in the field of cellular radiobiology. Other honors include the Maria Sklodowska-Curie medal from the Polish Radiation Research Society and the Hanns Langendorff medal from the German Radiation Protection Medical Association.

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117 peer-reviewed papers and numerous review papers in Polish journals. She has

ICRU Gray Medal The Gray Medal was established in 1967 by the International Commission on Radiation Units and Measurements (ICRU) to honor a scientist who has made outstanding contributions to basic or applied radiation sciences of interest to the ICRU. It honors the late Louis Harold (Hal) Gray, former member and Vice-Chairman of the Commission and a pioneer in experimental radiotherapy especially of the relevance of the oxygen effect. Profesor Eric J. Hall, this year’s recipient of the Gray Medal, is honored for his many contributions to the field of applied radiation sciences particularly for his pioneering work on radiation carcinogenesis and risk estimation from the medical use of radiation. Prof. Hall is The Higgins Professor of Radiation Biophysics at Columbia University, Professor of Radiology and Radiation Oncology and Director of The Center for Radiological Research. He has been in New York for over 35 years, after receiving his doctorate in radiobiology from Oxford University in the U.K. He has received more than 30 honors and awards, from societies in the U.S. and the U.K. including gold medals from ASTRO and RSNA, the Janeway Medal from The American Radium Society the Failla Award

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from the Radiation Research Society and the Kaplan Award of the IARR. Eric is an honorary fellow of both the American College of Radiology and The Royal College of Radiology, an honor conferred on few laboratory scientists. He is also a Fellow of ASTRO and the Society of Radiological Protection. Eric is the author of over 370 publications in peer-reviewed journals and has authored or co-authored four books, one of which, Radiobiology for the Radiologist, is the definitive text for students of radiation biology and is in its 6th edition. He

is

past

president of the Radiation Research Society, the American Radium Society and the International Association for Radiation Research. 77

Poster Session 3 PS3.1 - Biodosimetry 3 PS3001 - Operational issues influencing dose assessment by the dicentric assay: The effect of blood transport temperature and cell culture type Maria Moroni. PS3002 - Clonal structure of human lymphocyte pool predicts frequent presence of normal clones: Possible impact on cytogenetic biodosimetry several decades after radiation exposure for retrospective biodosimetry Yoshiaki Kodama, Mimako Nakano, Kazuo Ohtaki, Asao Noda, Nori Nakamura. PS3003 - Chromosome aberrations in the progeny of human lymphocytes exposed to energetic heavy ions Kerry George, Marco Durante, Todd Elliott, Francis Cucinotta.

PS3005 - Chronological changes of chromosomal translocation rates in spleen cells from mice continuously exposed to low doserate gamma-rays Atsushi Kohda, Takuo Toyokawa, Kazuaki Ichinoh, Yoichi Oghiso, Kimio Tanaka. 78

PS3007 - Micronucleus (MN) versus nucleoplasmic bridge (NPB) assessment for radiation biodosimetry in human lymphocytes Irena A. Nowak, Ollivier Hyrien, Yuhchyau Chen. PS3008 - Optimizing cytogenetic analysis for radiation-induced chromosomal aberration in C57Bl/6 mice Ying Tsai, Catherine Ferrarotto, Nancy Wang, Ruth Wilkins, Yuhchyau Chen. PS3009 - Relative biological effectiveness of low energy alpha particles in the survival of V79 hamster cells Bliss L. Tracy, Mark A. Hill, David L. Stevens, Dudley T. Goodhead. PS3010 - Comparison of BAC FISH with specific telomeres and centromere probes and chromosome painting on detection of radiation induced chromosome translocation and dose reconstruction Qing-Jie Liu, Xue Lu, Xiao-Wei Wang, Jiang-Bin Feng, Xiao-Ning Chen, Julie R. Korenberg, De-Qing Chen. ______________________________________

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PS3004 - Variable sensitivity of chromosomes 2, 8 and 14 in human peripheral blood lymphocytes exposed to 480 MeV/n 12C-IONS Marta Deperas-Kaminska, Gennady N. Timoshenko, Eugene A. Krasavin, Andrzej Wojcik.

PS3006 - Experience with biological dosimetry Horst Romm, Ursula Oestreicher.

PS3.2 - Bystander Effects 3 PS3011 - Radiation-induced chromosome instability and bystander effect in human peripheral blood lymphocytes in delayed terms following Chernobyl accident Maria A. Pilinskaya, Sergey S. Dibskiy, Olena W. Shemetun, Yelena B. Dibskaya, Oksana A. Talan, Ludmila R. Pedan. PS3012 - Radiation induced bystander studies in human prostate tumor cells Vered Anzenberg, Jeffrey A. Coderre. PS3013 - Radiation-quality dependence of genomic instability in mutation induced by the pre-treatment with low-fluence heavy ions Masao Suzuki, Chizuru Tsuruoka, Yukio Uchihori, Hisashi Kitamura.

PS3015 - New in vitro micronucleus assay to investigate bystander effect in artificial human 3D tissue system following low LET irradiation Giuseppe Schettino, David J. Brenner. PS3016 - Cellular response in imrt: three types of bystander effects Natalka Suchowerska.

PS3018 - Initiation and manifestation of genomic instability in irradiated and bystander populations Ryonfa Lee, James W. Kelly, Kim L. Chapman, Munira A. Kadhim. PS3019 - Study on bystander cell death inV79 cells using SR X-ray microbeam Munetoshi Maeda, Masanori Tomita, Noriko Usami, Katsumi Kobayashi. PS3020 - Low dose radiation-induced bystander effects in the spleen Benjamin J. Blyth, Edouard I. Azzam, Roger W. Howell, Pamela J. Sykes. PS3021 - Bystander response in human lymphocytes and leukemic cells by irradiated conditioned medium from human leukemic cells exposed to low and high dose of gamma radiation Badri N. Pandey, Amit Kumar, Lori Rastogi, Kaushala P. Mishra. PS3022 - Bystander effect in normal human fibroblast cells induced by very low-doses of X-ray irradiation Mitsuaki Ojima, Nobuhiko Ban, Michiaki Kai. ______________________________________ 79

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PS3014 - Analysis of heavy-ion induced bystander effect using microbeam irradiation Tomoo Funayama, Seiichi Wada, Takehiko Kakizaki, Nobuyuki Hamada, Yuichiro Yokota, Tetsuya Sakashita, Yasuhiko Kobayash.

PS3017 - How do experimental conditions and radiation affect cytokine signals? Angelica Facoetti, Daniele Alloni, Francesca Ballarini, Andrea Mairani, Luca Mariotti, Rosanna Nano, Andrea Ottolenghi.

PS3.3 - Cell Behavior/Stem Cells 3 PS3023 - Biochemical regularities of postradiation recovery in animal spermatozoa Kateryna Andreychenko, Alla Klepko, Nataliya Nurischenko. PS3024 - Cranial irradiation as a noninvasive tool to specifically alter adult hippocampal neurogenesis and induce hippocampaldependent cognitive deficits Nada Ben Abdallah, Robert K. Filipkowski, Piotr Jaholkowski, Leszek Kaczmarek, Martin Pruschy, Lutz Slomianka, Hans-Peter Lipp. PS3025 - X-ray sensitivity of endothelial stem/progenitor cells does not correlate with induction of apoptosis or absence of checkpoints Marc S. Mendonca, Helen ChinSinex, Ryan Dhaemers, Laura Mead, Merv C. Yoder, David A. Ingram.

PS3027 - Application of flow cytometry for the assessment of spermatozoid quality after ionizing irradiation Denys Vatlitsov, Ksenia Igrunova, Sergiy Andreychenko. PS3028 - Comparison of radiation sensitivity of rat respiratory tract epithelial cells 80

PS3029 - Effect of ionizing radiation on differentiation of human embryonic stem cells in culture Irina V. Panyutin, Eleanore J. Chuang, Igor G. Panyutin, Ronald D. Neumann. PS3030 - Intraesophageal manganese superoxide dismutase plasmid/liposome (MnSOD-PL) administration before irradiation increases engraftment of intraveneously injected esophageal stem cells Yunyun Niu, Michael W. Epperly, Hongmei Shen, Joel Greenberger. PS3031 - A single dose of gamma or proton radiation rapidly compromises skeletal structure of adult mice Hisataka Kondo, Jonathan Phillips, Charles L. Limoli, Eduardo A.C. Almeida, David John Loftus, Wenonah Vercoutere, Emily MoreyHolton, Rose Mojarrab, Munroop K. Atwal, Ruth K. Globus, Nancy D. Searby. PS3032 - Impact of 56Fe ion radiation on human neural stem cell differentiation Yongjia Yu, Yuanyuan Gao, Ping Wu. PS3033 - Valproic Acid significantly radiosensitzes MCF-7 cells in 2D, adherent clonogenic assays, but does not radiosensitize MCF-7 cells

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PS3026 - Effect of irradiation on labeling retaining cell population of the mouse mammary gland Irineu Illa Bochaca, Rodrigo Fernandez-Gonzalez, Markus C. Fleisch, Mary Helen Barcellos-Hoff.

Yutaka Yamada, Akifumi Nakata, Yoshiya Shimada.

grown in 3D, self-renewing nonadherent mammosphere culture Wendy A. Woodward, Jessica Li Li. PS3034 - Accumulation and persistence of mutations induced in somatic stem cells of mice during irradiation with low dose-rate gamma rays for 483 days Kazuo Fujikawa, Nao Kagawa, Tetsuya Ono, Isamu Hayata. PS3035 - Low dose irradiation inhibits BMP-induced osteodifferentiation with low LET X-rays and high LET 56Fe-HZE particles Paban K. Agrawala, Xinhua Lin, Louis A. Pena. ______________________________________ PS3.4 - Clinical Therapeutic Radiobiology 3

PS3037 - Radiation effects on noncancer diseases among the prenatally exposed atomic bomb survivors Yoshimi Tatsukawa, Eiji Nakashima, Michiko Yamada, Sachiyo Funamoto, Masazumi Akahoshi, Saeko Fujiwara. PS3038 - A review of epidemiological associations between low and moderate doses of ionizing radiation and late cardiovascular

PS3039 - Relationship between radiation exposure and age at menopause Ritsu Sakata, Yukiko Shimizu, Nobuo Nishi, Hiromi Sugiyama, Fumiyoshi Kasagi, Hiroko Moriwaki, Mikiko Hayashi, Manami Konda, Midori Soda, Akihiko Suyama, Kazunori Kodama. PS3040 - Circulatory disease mortality in atomic bomb survivors, 1950-2003 Yukiko Shimizu, Kazunori Kodama, Nobuo Nishi, Fumiyoshi Kasagi, Akihiko Suyama, Midori Soda, Hiromi Sugiyama, Ritu Sakata, Hiroko Moriwaki, Mikiko Hayashi, Manami Konda, Roy Shore. PS3041 - Therapeutic advantage of GRID therapy for a single high dose fraction using a multileaf collimator Kai Dou, John Ashburn, Prakash Aryal, Ellis Lee Johnson, Robert Zwicker. PS3042 - Cancer cure for a common man: experiences in delivering radiation treatment in rural India Mudundi R. Raju. PS3043 - Mathematical modeling of breast irradiation protocols - treatment success and failure 81

Wednesday

PS3036 - Systolic blood pressure and systolic hypertension in adolescence of in utero exposed atomic-bomb survivors Eiji Nakashima, Masazumi Akahoshi, Kazuo Neriishi, Saeko Fujiwara.

effects, and their possible mechanisms Mark P. Little, E Janet Tawn, Ioanna Tzoulaki, Richard Wakeford, Guido Hildebrandt, Francois Paris, Paul Elliott.

Heiko Enderling, Alexander R. Anderson, Mark A. Chaplain, Jayant S. Vaidya, Lynn Hlatky, Philip Hahnfeldt. PS3044 - Pulsed dose rate brachytherapy for carcinoma of cervix: experience at our institute DN Sharma, GK Rath. PS3045 - Stationary magnetic filed from MRI: A study on the exposed subjects Arnav Bhatia, Alka Kuma, Atul Kumar. PS3046 - A unified framework for biologically conformal radiation therapy (BCRT) treatment planning Yong Yang, Lei Xing. ______________________________________ PS3.5 - DNA Damage 3

PS3048 - Study for genetic effects of atomic-bomb radiation by using of a DNA microarray-based comparative genomic hybridization (array-CGH) method Norio Takahashi, Yasunari Satoh, Keiko Sasaki, Mieko Kodaira, Yoshiaki Kodama, Keiko Sugita, Naohiro Tsuyama, Hiroaki Katayama. 82

PS3050 - Polymorphisms in XRCC1 and XRCC3 genes as predictors of individual radiosensitivity Selena Palma, Tommaso Cornetta, Renata Cozzi, Tommaso Poggioli, Donatella Tirindelli, Antonella Testa. PS3051 - Combined effects of ionizing radiation and cadmium ions on DNA damage and gene expression in cultured medaka fish cells Dmytro Grygoryev, Oleksandr Moskalenko, John Zimbrick. PS3052 - Effects of gamma irradiation on the viability of Cryptosporidium parvum measured by real-time PCR Mikyo Joung, Sooung Lee, WooYoon Park, Jae-Ran Yu. PS3053 - Genomic instability induced in the descendants of normal human fibroblasts surviving heavy-ion irradiation Nobuyuki Hamada, Takamitsu Hara, Tetsuya Sakashita, Tomoo Funayama, Sakura Sora, Yasuhiko Kobayashi. PS3054 - Analysis of Common Deletion (CD) and a novel deletion of

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PS3047 - Analysis of differential transcriptional and proteome response of human lung derived cells exposed to single and multiple doses of gamma-rays Daniela Trani, Marco Cassone, Chiara Lucchetti, Marco Durante, Mario Caputi, Antonio Giordano.

PS3049 - Systemic effects of low-dose and low-dose-rate irradiation in C57BL/6 mice Hee-sun Kim, Seung-yeon Song, Suk-chul Shin, Shin-hye Oh, Chasoon Kim, Meeseon Jeong, Kwanghee Yang, Seon-yong Nam, Ji-young Kim, Chong-soon Kim.

mitochondrial DNA induced by ionizing radiation Ai Kurihara, Lu Wang, Yoshikazu Kuwahara, Taisuke Baba, Koji Ono, Manabu Fukumoto. PS3055 - Chromosome model reveals dynamic redistribution of DNA damage into nuclear sub-domains Sylvain V. Costes, Artem L. Ponomarev, James Chen, Francis A. Cucinotta, Mary Helen BarcellosHoff. PS3056 - Reproductive and genetic toxicity in male mice after chronic oral exposure to low level of depleted uranium Rong Li, Yanbing Leng, Yongping Su.

PS3058 - Permissible dose limit based on the analysis of stable chromosome aberrations in the lymphocytes Isamu Hayata. PS3059 - Effect of smoking reflected in the stable chromosome aberrations in the lymphocytes of the residents in the areas exposed to different environmental mutagens including radiation Wei Zhang, Chunyan Wang, Masako Minamihisamatsu, Luxin

PS3060 - Stable chromosome aberrations in the lymphocytes of the residents in different areas: A large city, and a high background radiation area and its control area in China Chunyan Wang, Wei Zhang, Masako Minamihisamatsu, Luxin Wei, Tsutomu Sugahara, Isamu Hayata. PS3061 - Transmission of genomic instability from a single irradiated human chromosome to the progeny of unirradiated cells Seiji Kodama, Naoki Mukaida, Hisakatsu Nawata, Kentaro Ariyoshi, Sanae Watanabe, Kazunori Shiraishi, Keiji Suzuki, Mitsuo Oshimura, Masami Watanabe. PS3062 - LET and ion-species dependence for cell-killing effect, mutation induction and chromosome aberration in normal human fibroblasts Tsuruoka Chizuru, Suzuki Masao, Furusawa Yoshiya, Okayasu Ryuichi, Anzai Kazunori. PS3063 - Long term transmissibility and stability of chromosome rearrangements in human cells exposed to ionizing radiation Richard Eberle, Bradford Loucas, Michael Cornforth. PS3064 - Single break driven chromosome instability in human cells Laure M. Sabatier. 83

Wednesday

PS3057 - Cytogenetic instability in peripheral blood T lymphocytes cultured in vitro from A-bomb survivors Kanya Hamasaki, Yoshiaki Kodama, Yoichiro Kusunoki, Eiji Nakashima, Norio Takahashi, Nori Nakamura, Kei Nakachi.

Wei, Tsutomu Sugahara, Isamu Hayata.

PS3065 - Induction of genome aneuploidization and nuclear DNA loss in gamma-irradiated rat spermatozoa Veronika Bulavytska. PS3066 - Potential evidence of radiationinduced genomic instability under chronic radiation exposure in man Galina Veremeyeva, Tatyana Varfolomeyeva, Alexander Akleyev. PS3067 - Cell killing and genomic instability in mutation induction on long-term CHO cells cultures irradiated with 290MeV/u carbon ions Xiao Wang, Yoshiya Furusawa, Masao Suzuki, Ryoichi Hirayama, Yoshitaka Matsumoto, Ying Qin.

PS3069 - Chromosomal aberrations in hypoxic cells with Cu-ATSM induced by Cu-K shell ionization Kaoru Takakura, Ayaka Shimmi, Yoshirou Kaji, Katsumi Kobayashi, Noriko Usami, Munetoshi Maeda, Yasuhisa Fujibayashi, Takako Furukawa, Hitoshi Imazeki, Hiroyuki Iso, Takahiro Ishikawa, Ryuichi Okayasu.

84

PS3071 - Genetic instability for Fruit Fly in the Terms of chronic irradiation Irene A. Kozeretskaya, Zhanna A. Omeltchenko, Alexandra P. Kravets. PS3072 - Distribution of micronuclei in human fibroblasts across the Bragg curve of light and heavy ions Megumi Hada, Shareen Lacy, Daila S. Gridley, Adam Rusek, Francis A. Cucinotta, Honglu Wu. PS3073 - Low-dose radioadaptive response of mouse blood and brain tissue to DNA damage Thomas Ernst Schmid, Francesco Marchetti, Sandhya Bhatnagar, Andrew Julius Wyrobek. ______________________________________ PS3.6 - DNA Repair 3 PS3074 - Comparison of initial chromosome break repair in cells irradiated with high and low LET radiation Emiko Sekine, Maki Okada, Dong Yu, Miho Noguchi, Akira Fujimori, Ryuichi Okayasu. PS3075 - Mutagenic potential of clustered DNA damage site in Escherichia coli Naoya Shikazono, Colin Pearson, John Thacker, Peter O'Neill.

Wednesday

PS3068 - M-BAND analysis of chromosome aberration in human epithelial cells exposed to γ-ray and secondary neutrons of low dose rate. Megumi Hada, Premkumar B. Saganti, Bradford Gersey, Richard Wilkins, Francis A. Cucinotta, Honglu Wu.

PS3070 - Relative biological effectiveness of 30 kV x-rays for micro-nucleated reticulocyte induction in mice, in vivo Lindsay Churchley, Jennifer Lemon, Fiona McNeill, Douglas Boreham.

PS3076 - Generation and characterization of DNA double-strand break repair gene deficient human cell lines Masahiko Mori, Takanori Katsube, Naoko Shiomi, Tadahiro Shiomi, Makoto Onoda. PS3077 - Effect of thiol-antioxidants, selenium-antioxidants and p53 inhibitor on ionizing radiation induced micronucleus formation in human lymphocytes Prabha Tiwari, Balakrishnan Sreedevi, S Kannan, H. S. Kushwaha, Kaushala Prasad Mishra. PS3078 - Aneuploidy and G1 checkpoint activation in human cells with reduced homologous recombination activity Mari Katsura, Yoshitaka Tomoda, Kiyoshi Miyagawa.

PS3080 - DSB repair kinetics after the exposure to high and low-LET conventional and microbeam radiation Rasa Ugenskiene, Kevin M. Prise, Melvyn Folkard, Janusz Lekki, Zbigniew Stachura, Wojciech M. Kwiatek, Monika Zazula, Jerzy Stachura.

PS3082 - Role of DNA crosslinks and DNA monoadducts in the toxicity of the mitomycins to Fanconi anemia cells Sara Rockwell, Maureen GilmoreHebert, Yanfeng Liu, Maria Tomasz. PS3083 - Distinct temporal associations between human RAD51, RAD52, and BCCIP after ionizing radiation and replication fork stalling Justin W. Wray, Jingmei Liu, Jac Nickoloff, Zhiyuan Shen. PS3084 - Lysine63 poly-ubiquitination protects against endogenous mutations Chantal Ramaekers, Roland K. Chiu, Philippe Lambin, Bradly G. Wouters. PS3085 - Induction and processing of oxidative clustered DNA lesions in the human breast cell lines MCF-7, MCF-10A, and HCC1937 Jessica M. Hair, Prakash Peddi, Dave Francisco, Brittany Flood, Angela Cecil, Alexandros Georgakilas. PS3086 - Low fluences of alpha particles do not induce SCE in cells defective in Rad51 paralogs Hatsumi Nagasawa, Paul F. Wilson, Yuanlin Peng, Y-C Lio, Nan Liu, Małgorzata Z. Zdzienicka, Larry H. Thompson, David J. Chen, Joel S. Bedford, John B. Little. 85

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PS3079 - Response of human peripheral lymphocytes to DNA damage caused by fractionated irradiation in vivo an in vitro Martina Rezacova, Jirina Vavrova, Doris Vokurkova, Emilie Lukasova, Karel Vodrazka.

PS3081 - Mutation induction in mammalian cells by 30 kV X-rays Juergen Kiefer, Hermann Witzenberger.

PS3087 - Persistence of radiation-induced foci after exposure of proliferating human mammary epithelial cells to sparsely and densely ionizing radiation Torsten Groesser, Bahram Parvin, Sylvain V. Costes, Mary Helen Barcellos-Hoff, Bjorn Rydberg. PS3088 - P53 inhibits in vitro and in vivo double-strand break repair in the absence of serine 15phosphorylation Peter Keng, Yi-Jang Lee, Dawn Mazzatti. . PS3089 - Assessment of individual variation in DNA double-strand break repair capacity in human primary diploid fibroblasts Paul F. Wilson, Salustra S. Urbin, Peter B. Nham, Cynthia B. Thomas, John M. Hinz, Irene M. Jones, Larry H. Thompson.

PS3091 - Changes in the distribution of human HAT1 after DNA damage Stefan T. Tafrov. PS3092 - Repair of strand breaks in E. coli by the Mycobacterium tuberculosis non-homologous end-joining proteins Douglas Wright, Svitlana Malyarchuk, Reneau Castore, Emily 86

PS3093 - Characterization of radiobiological endpoints in cells from RI mice Guanxiong Xiao, Hatsumi Nagasawa, Simon D Bouffler, Natalie L Degg, Yuanlin Peng, F. Andrew Ray, Alexander C Roby, Robert I Ullrich, Joel S Bedford, Michael M Weil. PS3094 - Repair of dsb at a specific site of chromosome: influence of lowdose/low-dose-rate gamma-rays Fumio Yatagai, Masao Suzuki, Noriaki Ishioka, Hitoshi Ohmori, Masamitsu Honma. PS3095 - Human Rad54B associates with werner syndrome protein WRN Yoshitaka Tomoda, Mari Katsura, Kiyoshi Miyagawa. PS3096 - Cohesin and the repair of radiation-induced DNA doublestrand breaks Christina Bauerschmidt, Cecilia Arrichiello, Michael Woodcock, David L. Stevens, Mark A. Hill, Susanne Burdak-Rothkamm, Kai Rothkamm. ______________________________________ PS3.7 - Experimental Therapeutics 3 PS3097 - The role of MEF/ELF4 in potentially lethal damage repair Chris van Bree, Nicolaas A.P. Franken, Jan Paul Medema.

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PS3090 - Relative biological efficiency for micro-nuclei induction after low doses of HZE Fe-ions, and the effect of polyethylene shielding Torsten Groesser, Eugene Chun, Mary Helen Barcellos-Hoff, Bjorn Rydberg.

Klepper, Bernard Weiss, Aidan Doherty, Lynn Harrison.

PS3098 - Survivin-t34a and -d53a enhanced radiation-induced apoptosis through abrogation of interaction with smac/diablo Aki Ogura, Osamu Inanami, Daisuke Iizuka, Hironobu Yasui, Mikinori Kuwabara. PS3099 - In vitro and in vivo studies of atm roles on growth kinetics, ros level, and sldr and pldr ability of human glioma cells Chu-Chiao Wu, Chi-Shiun Chiang. PS3100 - Effect of the trifunctional antibody catumaxomab to human tumor cells (FaDu) in 3D spheroid co-cultures Franziska Wawrsinek, Tobias Leidig, Wolfgang Mueller-Klieser. PS3101 - AMP-activated protein kinase: a potential novel target for radiotherapy in prostate cancer Sofie Isebaert, Johan Swinnen, Annelies Debucquoy, Willy Landuyt, William H. McBride, Adrian Begg, Karin Haustermans.

PS3103 - Radiosensitization effects of hsp27 gene silencing in different human tumor cells. in vivo validation on head and neck

PS3104 - MicroRNAs and Radelegans: understanding the genetic basis of the radiation response Joanne B. Weidhaas, Imran Babar, Sunitha Nallur, Sarah Roush, Michelle Boehm, Erin Gillespie, Frank J. Slack. PS3105 - Experimental study on expression property of pEgr-p16 and its anti-tumor effects induced by ionizing irradiation Jianxiang Liu, Xu Su. PS3106 - High-LET radiation enhanced apoptosis but not necrosis regardless of p53 status Akihisa Takahashi, Ken Ohnishi, Yoshiya Furusawa, Takeo Ohnishi. PS3107 - Significance of tumor heterogeneity in determining biological effectiveness of low and high LET radiation Koichi Ando, Sachiko Koike, Akiko Uzawa, Yoshiya Furusawa, Ryoichi Hirayama, Yoshitaka Matsumoto, Masahiko Watanabe. PS3108 - Normal tissue effect and growth delay of transplanted cancer in mice by synchrotron generated microplaner beam Yoshiya Furusawa, Masahiro Natsuhori, Arane Kasuya, Mitsunobu Muto, Toshifumi 87

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PS3102 - CI-1033, a pan-ErbB tyrosine kinase inhibitor, enhances the radiation response of human glioma cell lines Laurine E. Wedekind, M. Vincent.M. Lafleur, T. Rianne Stoter, Mark Luttjeboer, Peter Sminia, Ben J. Slotman, Gitta K. Kuipers.

squamous carcinoma cells xenografted tumors Elie Hadchity, Marie-Thérèse Aloy, Patrice Jalade, Christian Paulin, André-Patrick Arrigo, Martin Gleave, Claire Rodriguez-Lafrasse.

Oyamada, Nobuhiko Ito, Naoto Yagi, Masami Torikoshi, Ymiko Ohno, Masao Suzuki, Akiko Uzawa. PS3109 - Cellular sensitivity and p53independent apoptosis on human gingival cancer cells by heavy-ion beams Nobuhiro Yamakawa, Akihisa Takahashi, Ken Ohnishi, Yoshiya Furusawa, Takeo Ohnishi. PS3110 - p53-dependent regulation of induction of angiogenic regulatory factors by ion beam irradiation in vitro Masanori Hatashita, Keiichi Takagi, Kyo Kume, Shigekazu Fukuda, Sachiko Hayashi, Hideki Matsumoto. PS3111 - Smac gene enhances the bioeffect of EJ cells induced by 12C6+ ions irradiation Zhao Baofeng, Tian Mei, Ruan Jianlei, Su Xu.

PS3113 - Microarray analysis of radiationinduced genes in PC3 and DU 145 cells after single (10 Gy) and fractionated (1 Gy and 2 Gy) dose irradiation Molykutty J. Aryankalayil, Sanjeewani T. Palayoor, David Cerna, Mike Falduto, Scott Magnuson, Norman Coleman. PS3114 - Biophysical calculations of cell killing probability by the MK 88

PS3115 - Absorbed dose calculations predict therapeutic response in sodium iodide symporter expressing tumors Kimberly J. Krager, Andrew W. Gaut, Mark T. Madsen, Richard D. Hichwa, Michael M. Graham, Frederick E. Domann. ______________________________________ PS3.8 - Physics/Chemistry 3 PS3116 - Enhancement of DNA damage in ion beam radiotherapy through use of heavy atom doping Jean A. Wyer, V Senthil, Karl Butterworth, Shane W. J. Scully, Colin J. Latimer, Fred Currell, David Hirst, Dolan F. Byrne, Robert J. Pollard, Mansukh B. Shah. PS3117 - Specialties of animal reproduction under x-rays irradiation Olga Petrova, Sergiy Andreychenko. PS3118 - Secondary neutron production from patients during therapy with hadrons: are there potential risks Anwar M. Chaudhri. PS3119 - Photochemistry of the III generation photosenisitizers and Raman spectroscopy for breast cancer diagnosis

Wednesday

PS3112 - Protein expression profiles by radiation in a rat cirrhotic model Sookin Chung.

model and the LE model for heavyion beams Yuki Kase, Tatsuaki Kanai, Naruhiro Matsufuji, Yoshiya Furusawa, Thilo Elsaässer, Michael Scholz.

Halina Abramczyk, B. BrozekPluska, K. Kurczewski,. Kurczewska, P. Ciacka, M. Tazbir, Z. Morawiec, P. Wozniak, J. Parulski. PS3120 - Increased mercury release from dental amalgam restorations after exposure to microwave radiation emitted from mobile phones Seyed Mohammad Javad Mortazavi, Elham Daiee. PS3121 - Individual doses incurred from 1986 to 2006 by personnel of the health care units of the Ministry of National Defence and the Ministry of Interior and Administration in Poland. Agnieszka Kowalska, Jaroslaw Jazwinski, Marek K. Janiak.

PS3124 - The biophysical model for risk extrapolation needs modification Antone L. Brooks. PS3125 - Lung cancer risk of Mayak workers: Modelling of carcinogenesis and the bystander effect Peter Jacob, Reinhard Meckbach, Mikhail Sokolnikov, Viktor V. Khokhryakov, Evgeni Vasilenko. PS3126 - Two-stage carcinogenesis modeling: acute myeloid leukemia induced by X-rays and neutrons in mice Fieke Dekkers, Harmen Bijwaard. PS3127 - Theoretical approaches to cancer risk estimation Philip Hahnfeldt, Rainer K. Sachs, Lynn Hlatky.

______________________________________ PS3.9 - Radiation Carcinogenesis 3

PS3123 - Preliminary evidence for a doserate-dependent threshold for low dose suppression of low-LET radiation-induced neoplastic transformation in vitro J. Leslie Redpath, Xiaoyan Lao, Rubena Kapadia, Eric Giedzinski, Charles Limoli, Eugene Elmore.

PS3129 - Effects of oxidative metabolism on carcinogenesis in vitro Hanako Yoshii, Masami Watanabe. . PS3130 - A novel phenomenon "delayed division delay": evidence for delayed dna double-strand break and rejoining in the clonogenic progeny of cells surviving alpha or x irradiation Hiroshi Sasaki. 89

Wednesday

PS3122 - Secondary cancers after fractionated radiotherapy: stochastic population dynamics effects Rainer K. Sachs, David J. Brenner, Igor Shuryak, Hatim Fakir, Lynn Hlatky, Philip Hahnfeldt.

PS3128 - Verification of cancer induction model based on rat skin irradiations with different LET values Fredric J. Burns, Krystyna Frenkel, Moon-shong Tang, Arthur Nadas, Feng Wu, Ronghe Zhang.

PS3131 - Persistent phenotypic responses of human mammary epithelial cells induced by sparsely and densely ionizing radiation P. Kumari L. Andarawewa, Sylvain Costes, William S. Chou, Mary Helen Barcellos-Hoff. PS3132 - Determination of individuals sensitive to ionizing radiation on the base of cytogenetic examinations Emiliya Dyomina, Natalia Ryabchenko. PS3133 - Investigation of hot-spots associated with elements in the breakpoint cluster regions surrounding spi.1 gene deletions on chromosome 2 in radiationinduced aml in cba mice David G. Maranon, Michael M. Weil, Susan M. Bailey, Maria C. Muhlmann, Joel S. Bedford.

PS3135 - Hrad9 gene expression associated with prostate cancer Aiping Zhu, Xia Zhang, Xiangyuan Wang, Harshwardhan M. Thaker, Mahesh M. Mansukhani, Howard B. Lieberman. PS3136 - The "Cosmic Silence" experiment: on the potential adaptive role of environmental background radiation 90

PS3137 - Proteomic analysis of low dose arsenic and ionizing radiation exposure on keratinocytes Susanne R. Berglund, Alison R. Santana, Dan Li, David M. Rocke, Zelanna Goldberg. PS3138 - Patched1 and DNA-repair deficiencies in radiation induced cerebellar tumors Simonetta Pazzaglia, Mirella Tanori, Emanuela Pasquali, Mariateresa Mancuso, Simona Leonardi, Simonetta Rebessi, Vincenzo Di Majo, Roland Kanaar, Leon HF Mullenders, Anna Saran. PS3139 - Epigenetic signature of radiation exposure in the male germline Jan Tamminga, Olga Kovalchuk. PS3140 - Differential effects of low and high dose ionizing radiation on gene networks and pathways in human epithelial cells Sanchita Bhattacharya, L Ding, Mary Helen Barcellos-Hoff, AJ Wyrobek. ______________________________________ PS3.10 - Radioprotectors/Mitigators 3 PS3141 - Effect of metalloporphyrin antioxidant to reduce the radiation

Wednesday

PS3134 - Hydrogen peroxide mediates persistent radiation-induced genomic instability Disha Dayal, Sean M. Martin, Charles L. Limoli, Douglas R. Spitz.

Massimo Pinto, Francesca Antonelli, Fernanda Amicarelli, Marco Balata, Mauro Belli, Maria Cristina Carbone, Anna Maria Cimini, Laura Conti Devirgilis, Luca Ioannucci, Stefano Nisi, Orazio Sapora, Luigi Satta, Giustina Simone, Eugenio Sorrentino, Maria Antonella Tabocchini.

population damage in rat retinal following proton irradiation: A pilot study Xiao Wen Mao, Tsehay Mckomen, Nathan Lindsay, James Crapo, John Archambeau. PS3142 - Radiation-induced injury localized to the rat lung: changes in pulmonary function Swarajit N. Ghosh, Marylou L. Mäder, John E. Moulder, Elizabeth R. Jacobs, Timothy Lowry, Meetha Medhora. PS3143 - Evaluation of the radioprotective effects of genistein: survival, hematology, cytokines, and behavior M R. Landauer, V Srinivasan, V K. Singh, M H. Whitnall, T A. Davis, S R. Mog.

PS3145 - Radioprotection of normal lung tissue by two manganese porphyrin superoxide dismutase mimics Benjamin M. Gauter-Fleckenstein, Katharina C. Fleckenstein, Zahid N. Rabbani, Ines Batinic-Haberle, Zeljko Vujaskovic. PS3146 - LPS pretreatment changes the activation of irradiation response

PS3147 - EsA protects the lung against radiation-induced peumonitis and fibrosis Shanmin Yang, Hengshan Zhang, Wei Wang, Weimin Sun, Mei Zhang, Chaomei Liu, Yanghua Yi, Zhenyu Xiao, Paul Okunieff, Lurong Zhang. PS3148 - Radioprotective effects of ginsenoside rg1 on intestinal epithelial cells in vitro and in vivo Xing Cui, Makoto Akashi. PS3149 - A gastrointestinal radioprotector, FGF-P, normalizes circulating digestive protein levels after radiation Mei Zhang, Weimin Sun, Louis Pena, Jianjun Wang, Shanmin Yang, Hengshan Zhang, Wei Wang, Chaomei Liu, Steven Swarts, Paul Okunieff, Lurong Zhang. PS3150 - Mitigation and Treatment of Radiation-Induced Lung Damage by Genistein Andrea Para, Victoria Calveley, Aimee Langan, Ivan Yeung, Jake Van Dyk, Richard P. Hill. PS3151 - Induction of manganese superoxide dismutase (SOD2) activity in normal and tumor tissues by amifostine Jeffrey S. Murley, Yasushi Kataoka, Kenneth L. Baker, Mitchell C. Coleman, Douglas R. Spitz, David J. Grdina. 91

Wednesday

PS3144 - Small molecule inhibitors of glycogen synthase kinase-3 beta modulate radioprotection in developing hippocampus Dinesh Kumar Thotala, Dennis E. Hallahan, Eugenia M. Yazlovitskaya.

pathways in small intestinal crypt cells Fengchao Wang, Yongping Su, Yu Ning, Junping Wang, Xinze Ran.

PS3152 - Mitigation of radiation-induced skin injury by AAV2-mediated MnSOD gene therapy Shiqing Yan, Stephen L. Brown, Andrew Kolozsvary, Svend O. Freytag, Jae Ho Kim. PS3153 - Does total body irradiation result in chronic oxidative stress in normal kidney? Marek Lenarczyk, Mukut Sharma, Brian L. Fish, Marcus A. Crosby, John E. Moulder. PS3154 - Gene transfer of the multi-drug resistance 1 (MDR1) and manganese superoxide-dismutase (MnSOD) gene confers radioprotection on normal tissue cells Frederik Wenz, Marlon R. Veldwijk, Patrick Maier, Katharina Fleckenstein, Stefanie Laufs, Wolfgang J. Zeller, Stefan Fruehauf, Carsten Herskind.

PS3156 - Radioprotection of protein by manganese (II) Elena K. Gaidamakova, Vera Y. Matrosova, Min Zhai, Michael J. Daly. PS3157 - Minicircle Plasmid delivery of the human manganese superoxide 92

PS3158 - Radiation countermeasure efficacy of superoxide dismutase (SOD)/catalase (CAT) mimetic EUK-189 in mice exposed to Cobalt-60 gamma radiation Venkataraman Srinivasan, Susan Doctrow, Vijay K. Singh, Mark H. Whitnall. ______________________________________ PS3.11 - Signaling 3 PS3159 - NF-kB and MnSOD mediated adaptive radioresistance in low dose-irradiated mouse skin epithelial cells Ming Fan, Kazi Mokim Ahmed, Mitchell Coleman, Douglas R. Spitz, Jian Jian Li. PS3160 - Internal tandem duplication of FLT3 transduces increased ROS production, increased DNA damage, and reduced end-joining fidelity: Implications for disease progression in acute myeloid leukemia Kamal Datta, Kyu-Tae Kim, Dan Grosu, Annahita Sallmyr, Thomas A. Winters, Paul Shapiro, Donald Small, Feyruz V. Rassool. PS3161 - CuZnSOD overexpression enhances radioresistance of human

Wednesday

PS3155 - Absence of delayed negative sequelae in manganese superoxide dismutase-plasmid liposome intravenously treated protected survivors of total body irradiation Joel S. Greenberger, Tracy Smith, James J. Schlesselman, Michael W. Epperly.

dismutase (MnSOD) transgene confers radioprotection to 32Dcl3 hematopoietic progenitor cells in vivo Xichen Zhang, Michael W. Epperly, Mark A. Kay, Zhi-Ying Chen, Tracy Smith, Darcy Franicola, Joel S. Greenberger.

glioma cells by increasing cyclin B1 mRNA turnover and suppressing late reactive oxygen species accumulation Prabhat C. Goswami, Zhen Gao, Ehab Sarsour, Amanda Kalen. PS3162 - Cross talk between cell cycle checkpoint proteins and mitochondrial antioxidant defense in irradiated cells Ehab H. Sarsour, Sarita G. Menon, Iman M. Ahmad, Maher Abdalla, Venkatasubbaiah A. Venkatesha, Prabhat C. Goswami.

PS3165 - EGFR-ERK signaling through PARP coordinates DNA repair, apoptosis and proliferation Adly Yacoub, Joseph Kelley, Timothy Wallace, Paul Dent, Michael Hagan. PS3166 - Bioinformatics of highthroughput, quantitative mass spectrometry applied to radiationinduced genome instability

PS3167 - TNF-α-induced genomic instability in primary vascular endothelial cells Catherine F. Gibbons, Mohan Natarajan, Sumathy Mohan, Munira A. Kadhim, Andrew J. Grosovsky. PS3168 - Multiple molecular alterations in fibroblasts of a patient with radiation hypersensitivity / chromosomal fragility syndrome Reinhard Kodym, Gazi Alsbeih, Micheal Dean Story. PS3169 - Amplification of G1 checkpoint signalling by growth of IR-induced foci Motohiro Yamauchi, Yasuyoshi Oka, Seiji Kodama, Masami Watanabe, Keiji Suzuki. PS3170 - Phosphorylation of c-Myc on Ser62 by CDK5 is Essential for Cyclin G1-Mediated Transcriptional Activation of Cyclin B1 Haeng Ran Seo. PS3171 - Importance of 5'-AMP-activated protein kinase (AMPK) for tumor development Keith Laderoute, Khalid Amin, Joy Calaoagan, Merrill Knapp, Benoit Viollet. PS3172 - Distinct gene expression profiles following 10 Gy or iso-survival doses of radiation in human lymphoblastoid cells 93

Wednesday

PS3163 - Amplification of ATMdependent checkpoint signals coupled with DNA double strand break repair Keiji Suzuki, Motohiro Yamauchi, Seiji Kodama, Masami Watanabe. . PS3164 - Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks Nozomi Tomimatsu, Candice G.T. Tahimic, Akihiro Otsuki, Sandeep Burma, Akiko Fukuhara, David J. Chen, Akihiro Kurimasa.

John H. Miller, Shuangshuang Jin, William Morgan, David Springer.

Tzu-Pin Lu, Mong-Hsun Tsai, James B. Mitchell, Eric Y. Chuang. PS3173 - Regeneration mechanisms of ontogenetic radioadaptation in plants Alexandr Mikhyeyev, Svitlana Sytnik, Ludmila Ovsyannikova, Alla Dyachenko, Dmytro Grodzinzky. PS3174 - Characterisation of a novel protein, FKBPL; protein interactions and implications for pathways controlling cell growth and survival Keeva McClelland, Hayley McKeen, Andrea Valentine, David Hirst, Tracy Robson. PS3175 - Targeting the COP9 signalosome for cancer therapy Katharine S. Richardson, Ashraful Islam, Wayne Zundel.

PS3178 - Radiation-induced stress response in human skin Ray Warters, Sergey Zhuplatov, Sancy Leachman. 94

PS3.12 - Technical Advances/ Imaging/Models 3 PS3180 - Identification of differentially expressed genes contributing to radioresistance in lung cancer cells using microarray analysis Guozheng Guo, Wangfeng Guo. PS3181 - Establishment of reverse genetics in Medaka Takeshi Todo, Yasuhiro Kamei, Tomoko Ishikawa, Jin-hyong Kim. PS3182 - Develop a method to study radiation induced alternative splicing transcripts Tzu-Hung Hsiao, Eric Y. Chuang, Konan Peck. PS3183 - Genetic sensitivity in the transcriptomic response to low dose ionizing radiation Brynn Voy, Lisa Branstetter, Sudhir Naswa, Michael Langston, Arnold Saxton. PS3184 - Genetic dissection of susceptibility/resistance to ionizing radiation by use of recombinant congenic strain mice Alexander K. Vaglenov, Bernhard Kaltenboeck, William R. Brawner, David M. Carpenter, Anny Fortin, Henry W. Brandhorst, Li Yihang.

Wednesday

PS3176 - Sirt3: modulator of foxo3a activity? Mark V. Mishra, Kristi MuldoonJacobs, Phuongmai Nguyen, David Gius. PS3177 - Transcriptomic analysis of the effect of embryonic irradiation on cognitive functions Joris Verheyde, Arlette Michaux, Ann Janssen, Louis de SaintGeorges, Luc Leyns, Abderrafi Benotmane.

PS3179 - Changes in the expression of Keratinocyte Growth Factor and its receptor in oral mucosa (mouse) during daily fractionated irradiation Wolfgang Doerr, Astrid Fehrmann, Stefan Pieck. ______________________________________

PS3185 - Application of assisted reproductive technologies (ARTs) for radiobiological research Seiji Kito, Yuki Ohta, Yumiko Kaneko, Hiroko Yano, Tadahiro Shiomi, Naoko Shiomi, Shimada

Yoshiya, Kazuo Sakai. PS3186 - Lab-on-a-chip-system for systems radiation biology Stefan Thalhammer, Achim Wixforth, Wolfgang Heidenreich, Herwig Paretzke.

Wednesday 95

Thursday, July 12, 2007 7:30am - 8:15am Eye Openers

8:30am - 9:30am Congress Lectures

EO 13: Hematopoetic stem cells guide metastases Salon 7 Yerba Buena Ruth Muschel, Oxford University, Oxford, UK Chair: Eric Wright, University of Dundee, Dundee, UK ______________________________________

CL 19: Radiation response of cancer stem cells Salon 7 Yerba Buena Jeremy Rich, Duke University, Durham, USA Chair: Mark Dewhirst, Duke University, Durham, USA ______________________________________

EO 14: Nanoparticles in cancer and radiation biology Salons 1, 2, 3 Yerba Buena Gayle Woloschak, Northwestern University, Chicago, USA Chair: Zvi Fuks, Memorial Sloan-Kettering Cancer Center, New York, USA ______________________________________

CL 20: Repair of radiation induced DNA double strand breaks during the mammalian cell cycle Salon 8 Yerba Buena Markus Lobrich, University of Saarland, Saarbrucken, Germany Chair: Bo Stenerlow, Uppsala University, Uppsala, Sweden ______________________________________

EO 15: Understanding the chemistry of stored defense nuclear waste: Studies of waste stimulants Salons 4, 5, 6 Yerba Buena Donald Camaioni, Pacific Northwest National Lab, Richland, USA Chair: Simon Pimblott, University of Manchester, Manchester, UK ______________________________________

96

CL 22: Late effects of radiation Salons 4, 5, 6 Yerba Buena Michael Robbins, Wake Forest University, Winston-Salem, USA Chair: Eleanor Blakeley, Lawrence Berkeley National Laboratory, Berkeley, USA ______________________________________

Thursday

EO 16: The good and the bad of tumor suppression Salon 8 Yerba Buena Gerard Evan, University of California, San Francisco, San Francisco, USA Chair: Laura Attardi, Stanford University, Stanford, USA ______________________________________

CL 21: Radiation chemistry of DNA in cells Salon 15 Yerba Buena Jean Cadet, Commissariat à l’Énergie Atomique, Grenoble, France Chair: Melanie Spotheim-Maurizot, Centre National de la Recherche Scientifique, Orleans, France ______________________________________

CL 23: Radiation induced bystander effects: The good, the bad and the ugly Salons 10, 11 Yerba Buena Carmel Mothersill, McMaster University, Hamilton, Canada Chair: Kathryn Held, Massachusetts General Hospital, Boston, USA ______________________________________ CL 24: Influence of angiogenesis on cancer treatment Salons 1, 2, 3 Yerba Buena Gillian Tozer, University of Sheffield, Sheffield, UK Chair: Sydney Evans, University of Pennsylvania, Philadelphia, USA ______________________________________ 10:00am - 12:00pm Symposia S 33: Adaptive Response Induction by Low Dose and Low Dose Rate Salons 1, 2, 3 Yerba Buena Chair: Ron Mitchel, Atomic Energy of Canada Limited, Chalk River, Canada 10:00 - Molecular pathways utilized by human cells that undergo the cytogenetic radioadaptive response Andrew Wyrobek, Lawrence Berkeley National Laboratory, Berkeley, USA

11:30 - Exploring the mechanisms of the adaptive response at Chernobyl Brenda Rodgers, Texas Tech University, Lubbock, USA ______________________________________ S 34: Reaction Pathways Leading to DNA Damage Salon 15 Yerba Buena Chair: Thierry Douki, Commissariat à l’Énergie Atomique, Grenoble, France 10:00 - Independent generation of reactive and metastable intermediates for elucidating the effects of ionizing radion on DNA

Marc M. Greenberg, John Hopkins University, Baltimore, USA 10:30 - Clustered damage due to auger electrons Pavel Lobachevsky, Peter MacCallum Cancer Centre, Melbourne, Australia 11:00 - Biological oxidants produce unique sequence-selective oxidation patterns in doublestranded DNA Yelena Margolin, Massachusetts Institute of Technology, Boston, USA

Thursday

10:30 - Adaptive responses to EXTREMELY low conditioning doses of low LET radiation Pam Sykes, Flinders University of South Australia, Adelaide, Australia

11:00 - Combined effects of low dose/dose-rate irradiation and some tumorigenic agents Kazuo Sakai, Central Research Institute of Electric Power Industry, Japan

11:30 - Spectrum of lesions observed in vivo

97

Thierry Douki, Commissariat à l’Énergie Atomique, Grenoble, France ______________________________________ S 35: Radiation Biology, Chemistry and Physics of Nuclear Power Salon 14 Yerba Buena Chairs: Yosuke Katsumura, University of Tokyo, Tokyo, Japan Dorota Swiatla-Wojcik, Institute of Applied Radiation Chemistry, Lodz, Poland Introduction Xu Su, Chinese Center for Medical Response to Radiation Emergency, Beijing, China 10:00 - Chemistry of closing the nuclear fuel cycle Carol Burns, Los Alamos National Laboratory, Los Alamos, USA 10:30 - Interfacial processes in waterurania systems Catherine Corbel, Commissariat à l’Énergie Atomique, Gif-sur-Yvette, France 11:00 - Radiation damage to nuclear materials Colin English, Nexia Solutions Ltd., Sellafield, UK 11:30 - Radiation chemistry of water at high temperature and pressures Yosuke Katsumura, University of Tokyo, Tokyo, Japan ______________________________________ S 36: Mechanisms of Radiation Induced Bowel Damage and Possible Intervention Strategies Salons 4, 5, 6 Yerba Buena 98

Chairs: Fiona Stewart, Nethelands Cancer Institute, Amsterdam, The Netherlands Marie-Catherine Vozenin-Brotons, Institute de Radioprotection et de Surete Nucleaire, Villejuif, France 10:00 - Molecular mechanisms of radiation induced intestinal inflammation Meritxell Molla, University of Barcelona, Barcelona, Spain 10:30 - Radiation induced rectal telangiectasis Jacqueline Kruse, Netherlands Cancer Institute, Amsterdam, The Netherlands 11:00 - Cytokine cascades and radiation induced fibrosis Marie-Catherine Vozenin-Brotons, Institute de Radioprotection et de Surete Nucleaire, Villejuif, France 11:30 - Endothelial dysfunction: key to the chronicity of intestinal radiation fibrosis Martin Hauer-Jensen, University of Arkansas, Little Rock, USA ______________________________________ S 37: Radiation-induced genomic instability Salon 8 Yerba Buena Chairs: Takeo Ohnishi, Nara Medical University, Nara, Japan, Munira Kadhim, Medical Research Council, Oxford, UK 10:00 - The biological function of radiation-induced nitric oxide radicals through Hdm2-p53 interaction Takeo Ohnishi, Nara Medical University, Nara, Japan,

10:30 - A role for mitochondrial dysfunction in radiation induced genomic instability William Morgan, University of Maryland, Baltimore, USA 11:00 - NHEJ and the double-strand break response in IgH class switch recombination and translocations Frederick Alt, Harvard University, Cambridge, USA 11:30 - Fetal irradiation induced genomic instability in mouse hemopoietic stem cells P. Uma Devi, Kasturba Medical College, Manipal, India ______________________________________ S 38: Tumor Metabolism and Metastases Salon 7 Yerba Buena Chairs: Ian Stratford, University of Manchester, Manchester, UK Amato Giaccia, Stanford University, Stanford, USA 10:00 - The tumor microenvironment and metastasis Richard Hill, University of Toronto, Toronto, Canada 10:30 - The role of hypoxia-induced lysyl oxidase in metastasis Janine Erler, Stanford University, Stanford, USA 11:00 - Hypoxia and remodeling of tumor microenvironment Zhong Yun, Yale University, New Haven, USA

12:00pm - 1:00pm Plenary Lecture PL 5: Stem cells in cancer Salon 9 Yerba Buena Irving L. Weismann, Stanford University, Stanford, USA Chair: Elizabeth Travis, The University of Texas MD Anderson Cancer Center, Houston, USA ______________________________________ 2:00pm - 4:00pm Symposia S 39: Cancer Stem Cells Salon 7 Yerba Buena Chair: Michael Clarke, Stanford University, Stanford, USA 2:00 - The response of breast cancer stem cells to cancer treatment Frank Pajonk, University of California, Los Angeles, Los Angeles, USA 2:30 - Wnt/β-catenin signaling in intestinal and mammary cancer stemness Ricardo Fodde, Erasmus University Medical Center, Rotterdam, The Netherlands 3:00 - Epithelial cancer stem cells and resistance to radiation Michael Clarke, Stanford University, Stanford, USA ______________________________________

Thursday

11:30 - Inhibiting metastatic spread and metastatic growth Ian Stratford, University of Manchester, Manchester, UK ______________________________________ 99

S 40: The Relationship between Checkpoint Signaling and DNA Repair Salon 8 Yerba Buena Chair: Ted DeWeese, Johns Hopkins University, Baltimore, USA 2:00 - Investigating the molecular network involving NFBD1/MDC1 in response to DNA damages Phang-Lang Chen, University of California, Irvine, Irvine, USA 2:30 - Chromatin remodeling in checkpoints and repair Sang Eun Lee, University of Texas, San Antonio, San Antonio, USA 3:00 - The role of ATM and ATR in hypoxia induced replication arrest and recovery Esther Hammond, Stanford University, Stanford, USA 4:00 - Activation of the DNA damage checkpoint in the absence of DNA damage David Toczyski, University of California, San Francisco, San Francisco, USA ______________________________________ S 41: Clustered and Tandem DNA Lesions Salons 10, 11 Yerba Buena Chairs: Peter O’Neill, Medical Research Council, Oxford, UK Naoya Shikazono, Japan Atomic Energy Research Institute, Takasaki, Japan

3:00 - Chemical detection and mechanisms of formation of tandem DNA damage Jean Luc Ravanat, Commissariat à l’Énergie Atomique, Grenoble, France 3:30 - Induction of clustered DNA damage in cells Betsy Sutherland, Brookhaven National Laboratory, Upton, USA ______________________________________ S 42: Radiation and Polymers Salon 15 Yerba Buena Chairs: Seiichi Tagawa, University of Osaka, Osaka, Japan Alison M. Funston, University of Melbourne, Melbourne, Australia 2:00 - Charge and energy transfer through conjugated polymers Sina Burkert, Leibniz Institute of Polymer Research, Dresden, Germany 2:30 - Production of H2 in the radiolytic degradation of polymers Shu Seki, University of Osaka, Osaka, Japan 3:00 - Polymer nanowire formation along single particle tracks Seicchi Tagawa, University of Osaka, Osaka, Japan 3:30 - Properties of oligofluorenes Piotr Ulanski, Technical University of Lodz, Lodz, Poland

Thursday

2:00 - DNA repair of clustered DNA damage in cells Lynn Harrison, Louisiana State University, Shreveport, USA 100

2:30 - Mechanisms of processing clustered DNA damage and “dirty” DSB Peter O’Neill, Medical Research Council, Oxford, UK

S 43: Influence of the Tumor Vasculature on Response to Therapy Salons 1, 2, 3 Yerba Buena Chairs: Adriana Haimovitz-Friedman, Memorial Sloan-Kettering Cancer Center, New York, USA Donald McDonald, University of California, San Francisco, San Francisco, USA 2:00 - Cellular actions on angiogenesis inhibitors on tumor blood vessels Donald McDonald, University of California, San Francisco, San Francisco, USA 2:30 - Optimization of the treatment modality combining ionizing radiation with inhibitors of angiogenesis Martin Pruschy, University Hospital Zurich, Zurich, Switzerland 3:30 - Assessment of novel hypoxia response pathways as clinical molecular targets Adriana Haimovitz-Friedman, Memorial Sloan-Kettering Cancer Center, New York, USA ______________________________________

2:00pm - 4:00pm Workshops Is the Bystander Effect Relevant to Radiation Response in vivo? Salons 4, 5, 6 Yerba Buena Chairs: Colin Seymour, McMaster University, Hamilton, Canada William Morgan, University of Maryland, Baltimore, USA ______________________________________

W 7:

Relevance of Telomeres to Radiation Biology Salons 12, 13 Yerba Buena Chairs: Susan Bailey, Colorado State University, Fort Collins, USA John Murnane, University of California, San Francisco, San Francisco, USA ______________________________________ W 8:

4:00pm - 5:30pm Poster Session 4 ______________________________________ 5:45pm Closing Ceremony Salons 9 Yerba Buena ______________________________________ 7:00pm Gala Dinner Salons 7, 8 Yerba Buena ______________________________________

Thursday 101

Poster Session 4 PS4.1 - Biodosimetry 4 PS4001 - Discovery of Sam68 as a Biomarker of Apoptosis induced by γ-irradiation in immune system Yang Kwang-Hee, Moo Hyun Choi, Min Young Kim, Seon Young Nam, Meeseon Jeong, Cha Soon Kim, Hee Sun Kim, Young-Woo Jin, Sungkwan An, Suhkneung Pyo, Chong Soon Kim. PS4002 - Investigation of the serum proteome to look for ionizing radiation biomarkers Olivier Guipaud, Valerie Vereycken-Holler, Joëlle Vinh, Patrick Gourmelon, Marc Benderitter. PS4003 - In vivo expression of p53 and stat3 dependent genes after ionizing radiation Marcy B. Grace, Antonino Germana, Dadin Fu, Thomas B. Elliott, William F. Blakely, G. David Ledney.

PS4005 - Radiation-induced phosphorylation of p53 on ser 15 in MOLT4 cells is dose-dependent 102

PS4006 - Expression monitoring of six new radiation responsive genes M. Ahmad Chaudhry. PS4007 - Risk assessment of radiation exposure using molecular biodosimetry Todd F. Elliott, Kerry George, Dianne K. Hammond, Francis A. Cucinotta. PS4008 - Development of a risk assessment system of toxicants by HiCEP Katsutoshi Suetomi, Akira Fujimori, Yoshihisa Kubota, Sentaro Takahashi. PS4009 - Radiation metabolomics permits discovery of mouse urinary biomarkers for gamma radiation exposure John B. Tyburski, Josef Slavik, Kristopher W. Krausz, Kathryn Doiron, Christian Lanz, Albert J. Fornace, Jr, Frank J. Gonzalez, Jeffrey R. Idle. PS4010 - A novel method for biodosimetry Jeff W. Bacher, Wael Abdel Megid, Martin G. Ensenberger, Richard B. Halberg, Stephen A. Stanhope, Marijo G. Kent-First, Tomas A. Prolla.

Thursday

PS4004 - In vivo murine dose-response calibration curves for earlyresponse exposure assessment using multiple radiationresponsive blood protein biomarkers Natalia I. Ossetrova, David J. Sandgren, William F. Blakely.

Ales Tichy, Darina Zaskodova, Martina Rezacova, Jirina Vavrova, Zuzana Rehakova, Zdena Vilasova, Jaroslav Pejchal, Jan Osterreicher.

PS4011 - Estimating the genotoxic effects of Fe-ions: impact of cell cycle effects, apoptosis and intraindividual variability Sylvia Ritter, Ryonfa Lee, Sylvester Sommer, Elena Nasonova. PS4012 - Gene expression profiles for radiation biodosimetry with a fully integrated biochip Sunirmal Paul, Ralf Lenigk, Christine Orosco, Mark Richards, Frederic Zenhausern, Sally A. Amundson. PS4013 - Stable amino acid end-products in proteins irradiated in the solid state: potential use as biodosimeters of radiation exposure in human populations Steven G. Swarts, Katerina A. Naumenko, William A. Bernhard. PS4014 - Potential use of early cytokine changes as surrogate markers of low dose irradiation Eric Hernady, Jacqueline P. Williams, Carl Johnston, Christina Reed, Jacob N. Finkelstein. PS4015 - Proteomic expression studies after in vivo irradiation Daniela L. Stricklin, Margaretha Lundquist, Micael Granström.

PS4017 - Radio-adaptive response of cultured salmon cells exposed to ionizing radiation Michael F. Kilemade, Jennifer A. Lennon, Douglas R. Boreham. PS4018 - Effects of low dose irradiation on the quantitative and qualitative changes of major immune parameters and on the immune surveillance in mice Katalin Lumniczky, Tunde Szatmari, Geza Safrany. PS4019 - Targeted irradiation of single fibroblasts with heavy ions reveals transient cell cycle related changes but no DNA damage in bystander cells Claudia Fournier, Philippe Barberet, Thomas Pouthier, Sylvia Ritter, Gisela Taucher-Scholz. PS4020 - “Medium mediated” bystander effect induced by α-particle irradiated human fibroblasts Francesca Antonelli, Mauro Belli, Giuseppe Esposito, Orazio Sapora, Giustina Simone, Eugenio Sorrentino, Maria Antonella Tabocchini. PS4021 - Distinct neuroinflammatory responses to gamma versus HZE particle irradiation Sean D. Hurley, Jaqueline Williams, Lee A. Trojanczyk, Michael J. Moravan, John A. Olschowka, M. Kerry O'Banion.

103

Thursday

PS4016 - Differential diagnosis of responses caused by radiation or chemical exposure Hee-Kyung Kwon, Hyung-A Kim, Hyun-Jin Yun, Ji-Eun Kim, HyeKyung Shin, Su-Jae Lee, Chang-Mo Kang. ______________________________________

PS4.2 - Bystander Effects 4

PS4022 - Delayed genomic instability in bystander cells Burong Hu, Peter Grabham, Adayabalam Balajee, Brian Ponnaiya, Tom K. Hei, Charles R. Geard. PS4023 - Radiation-induced bystander responses in mouse testes Prasad V.S.V. Neti, Venkat R. Narra, Hosea F. Huang, Edouard I. Azzam, Roger W. Howell. PS4024 - X-ray irradiated lymphoblastoid cells caused media mediated bystander effects Asima Chakraborty, Robert W. Redmond, Martin Purschke, Kathryn D. Held. PS4025 - Performance of an energytunable X-ray microbeam irradiation system developed at the Photon Factory Katsumi Kobayashi, Noriko Usami, Munetoshi Maeda, Hiroshi Maezawa, Tohru Hayashi, Kotaro Hieda, Kaoru Takakura, Yoshiya Furusawa.

PS4027 - Tracking Genomic Instability within irradiated and bystander populations 104

PS4028 - Bystander response to an X-ray microbeam using three different DNA damage response markers in epithelial cells Eleanor A. Blakely, Polly Y. Chang, Richard I. Schwarz, Kathleen A. Bjornstad, Chris J. Rosen, Rajeeb Khatua, Christy L. Wisnewski, Bahram Parvin1, Al C. Thompson. ______________________________________ PS4.3 - Cell Behavior/Stem Cells 4 PS4029 - Anti-tumor activity of murine NK cells after single or fractionated exposures to 0.1, 0.2 or 1.0 Gy X-rays Aneta Cheda, Ewa M. Nowosielska, Jolanta Wrembel-Wargocka, Tomasz Ołdak, Marek K. Janiak. PS4030 - Anti-tumor activity of murine peritoneal macrophages after single or fractionated exposures to 0.1, 0.2 or 1.0 Gy X-rays Ewa M. Nowosielska, Aneta Cheda, Jolanta Wrembel-Wargocka, Tomasz Ołdak, Marek K. Janiak. PS4031 - Using hybrid spheroids to assay cancer stem cell sensitivity to ionizing radiation and chemotherapeutics Christopher S. Lange, Bozidar Djordjevic, Shy'Ann Jie, Saira Hafeez, Joshua Garren, David J. Goff, Ovadia Abulafia, Allison Wagrich, Marvin Rotman.

Thursday

PS4026 - Study of combined action of very low dose-rate gamma-radiation and radioactive strontium on mice in vivo: dose response, adaptive response, and genetic instability Elena Niyazova, Svetlana Zaichkina, Olga Rozanova, Gella Aptikaeva, Asiya Akhmadieva, Elena Smirnova, Olga Vachrusheva.

James W. Kelly, Jeremy S. Taylor, Munira A. Kadhim.

PS4032 - Radiation-induced genomic instability in tandem repeat sequences is not predictive of unique sequence instability Asao Noda, Yoshiaki Kodama, Harry M. Cullings, Nori Nakamura. PS4033 - P53 mutant dependent and glutathione independent glucose regulated γ radiation response in human cancer cells Iraimoudi S. Ayene, Jie Li, Kathleen Ward. PS4034 - Ionizing radiation modulates HLA expression in two human melanoma cell lines Severino Michelin, Diana Dubner, Maria del R Perez, Mariana Malvicini, Edgardo Carosella, Michel Bourguignon. PS4035 - In vitro lactate consumption in human cancer cell lines Kelly Kennedy, Thies Schroeder, Ashley Chi, Mark W. Dewhirst. PS4036 - Adaptive responses of long term radiation on tumorigenic and nontumorignic human prostate cell lines Danupon Nantajit, Kazi Mokim Ahmed, Ming Fan, Zhaoqing Wang, Jian Jian Li.

PS4.4 - Clinical Therapeutic Radiobiology 4 PS4039 - Radiogenomics of prostate cancer: identification of genomic markers for normal tissue radiotoxicity Sambasivarao Damaraju, David Murray, Gino Fallone, Carol Cass, John Hanson, Matthew Parliament. PS4040 - Volume effects in the rat lung for late radiation-induced loss of lung function Peter van Luijk, Hette Faber, Jacobus M. Schippers, Harm Meertens, Johannes A. Langendijk, Robert P. Coppes. PS4041 - Impact of SNP´s in risk genes on fibrosis after radiotherapy Kerstin Borgmann, Inga Boeckelmann, Sonko Borstelmann, Annette Raabe, Oliver Zschenker, Ulrike Hoeller, Dirk Rades, Ekkehard Dikomey. PS4042 - A little to a lot or a lot to a little: evaluation of lung response to ionizing radiation using a rat model Vladimir A. Semenenko, Robert C. Molthen, Swarajit N. Ghosh, Meetha 105

Thursday

PS4037 - A translationally controlled angiogenic switch in breast cancer Robert J. Schneider, Ksenia Karpisheva, Steve Braunstein, Carolina Pola, Judith Goldberg, Silvia C. Formenti.

PS4038 - Glioma cancer stem cells promote tumor radioresistance and angiogenesis Jeremy N. Rich, Shideng Bao, Qiulian Wu, Roger E. McLendon, Sith Sathornsumetee, Zhizhong Li, Mark Dewhirst, Darell D. Bigner, Anita B. Hjelmeland. ______________________________________

M. Medhora, Natalya V. Morrow, X. Allen Li. PS4043 - Association between polymorphisms in candidate genes and late complications to radiotherapy in Head and Neck cancer patients Ghazi Alsbeih, Najla Al-Harbi, Khaled Al-Hadyan, Muneera AlBuhairi, Medhat El-Sebaie, Nasser Al-Rajhi. PS4044 - The implications of DNA damage checkpoints on acute radiation effects in normal epithelium Ingela Turesson, Jan Nyman, Ragnhild Bernefors, Majlis Book, Ingegerd Hermansson, Fredrik Qvarnstrom, Martin Simonsson, Sunna Sigurdardottir, Ulf Thunberg, Karl-Axel Johansson. PS4045 - Heart irradiation and late radiation-induced loss of lung function Peter van Luijk, Hette Faber, Jacobus M. Schippers, Johannes A. Langendijk, Harm Meertens, Robert P. Coppes. PS4046 - p53 polymorphism at codon 72 predicts individual radiosensitivity of acute skin reactions Ulf Thunberg, Jan Nyman, Majlis Book, Ingegerd Hermansson, KarlAxel Johansson, Ingela Turesson.

106

PS4048 - Stereotactic radiosurgery (SRS) improves locomotor recovery and function after spinal cord injury Chitti Moorthy, Ronald Rocchio, Alan Alfieri, Lynn Shih, Nagwa, Saleh, Richard J. Zeman, Xialing Wen, Nengtai Ouyang, Joseph D. Etlinger. ______________________________________ PS4.5 - DNA Damage 4 PS4049 - Hierarchy of complex doublestrand break repair: 8-oxoguanine retards DSB repair when in close proximity to the break termini Tracey A. Dobbs, Philip Palmer, Martine E. Lomax, Peter O'Neill. PS4050 - Extremely low frequency magnetic fields enhance chemically induced formation of apurinic/apyrimidinic sites in A172 cells Shin Koyama, Tomonori Sakurai, Takehisa Nakahara, Junji Miyakoshi. PS4051 - Development of a true internal standard for the comet assay to minimise variability in the measures of radiation-induced DNA damage formation and repair George Don D. Jones, Murizal Zainol, Julia Stoute, Karen Bowman, Gabriela Almeida.

Thursday

PS4047 - Radiation-induced pathophysiology, in particular late effects after radiotherapy, is inversely proportional to the rate

of induction of radiation-induced apoptosis in T lymphocytes Nigel E. Crompton, Joel Strehl, Natalie Kent, Catherine Carter, Elianna Bootzin, Rick Hay.

PS4052 - Analysis of clustered DNA damage generated by high LET radiations Hiroshi Ide, Hiroaki Terato, Yusuke Nakaarai, Ryoichi Hirayama, Yoshiya Furusawa. PS4053 - Role of DNA-PKcs in DSB repair following high and low dose radiation Jennifer Anderson, Jane Harper, Peter O'Neill. PS4054 - Rbe of double-strand breaks from 211at Kristina Claesson, Bo Stenerlow, Lars Jacobsson, Kecke Elmroth. PS4055 - Rejoining of DNA double-strand breaks and clastogenic effects in higher-plant tobacco cells irradiated with gamma rays Yuichiro Yokota, Seiichi Wada, Atsushi Tanaka, Issay Narumi. PS4056 - Induction of strand breaks, and base lesions in dry plasmid DNA films induced by 270 - 560 eV ultrasoft X-rays Kentaro Fujii, Akinari Yokoya, Naoya Shikazono. PS4057 - A novel methodology for characterizing strand-break termini and damaged bases in plasmid DNA exposed to ionizing radiations Ken Akamatsu, Seiichi Wada, Yasuhiko Kobayashi.

PS4060 - Understanding interstrand crosslink formation in bromodeoxyuridine substituted DNA Marie-Eve Dextraze, Sylvain Cecchini, Sonia Girouard, Richard J. Wagner, Darel J. Hunting. PS4061 - Double strand break repair in human lymphocytes irradiated with ionising radiation and incubated in microgravity Maddalena Mognato, Roberto Cherubini, Lucia Celotti. PS4062 - Cancer cells modulate DNA DSB/Repair in nontransformed cells Afshin Beheshti, Heiko Enderling, Matthew Perkins, Aaron Burg, Katarina Luptakova, Amir Abdollahi, Philip Hahnfeldt, Lynn Hlatky. PS4063 - UV-C radiation induces single strand breaks in DNA by inducing conformational relaxation of the helix and affects the restriction profile of DNA Chaitali Bhattacharjee. PS4064 - A novel technique using DNA denaturation to analyze clustered DNA damage sites induced by densely ionizing radiation Akinari Yokoya, Naoya Shikazono, Takeshi Ushigome, Ayumi Urushibara, Kentaro Fujii. 107

Thursday

PS4058 - DNA double-stranded breaks indicate general cell stress Jennifer S. Dickey, Olga A. Sedelnikova, Mykyta V. Sokolov, William M. Bonner.

PS4059 - DNA strand breaks, DNAprotein cross-links and apoptosis in mice exposed to low dose-rate gamma-radiation Andreyan N. Osipov.

PS4065 - Formation of DNA repair protein foci at clustered damage sites in high-LET irradiated cells Bo Stenerlow, Irina Radulescu, Kristina Viktorsson, Martin Simonsson, Fredrik Qvarnstrom, Karin H. Karlsson, Rolf Lewensohn. PS4066 - Analysis of DNA damage spectra induced by irradiations with the same HZE ion and different energies Deborah J. Keszenman, Betsy M. Sutherland. PS4067 - Visualization of the damage induction and the accumulation of RAD51 in the cells irradiated with synchrotron X-ray microbeam Noriko Usami, Kiyomi EguchiKasai, Masahiko Mori, Katsumi Kobayashi. PS4068 - Iodine-125 radioprobing of intramolecular quadruplex conformation of human telomeric DNA: effects of flanking sequences, ionic conditions and quadruplex-specific drugs Timur I. Gaynutdinov, Ronald D. Neumann, Igor G. Panyutin.

108

PS4071 - Telomere dysfunction and DNA repair deficiency: markers of sensitivity to mutagens and carcinogens? Jennifer Newman, Birendranath Banerjee, Lakshmidevi Balakrishnan, Manikandan Jayapal, Aik Kia Khaw, Anuradha Poonepalli, Rabindra N. Bhattacharjee, Rajamanickam Baskar, Han-Woong Lee, Alirio Melendez, M. Prakash Hande. PS4072 - Radiation quality effect on telomere elongation of irradiated mammalian cells Francesco Berardinelli, Antonella Sgura, Antonio Antoccia, Giacomo Cuttone, Roberto Cherubini, Silvia Gerardi, Caterina Tanzarella. PS4073 - Association of radiation-induced senescence of articular chondrocytes with plakoglobin accumulation Eun-Hee Hong, Ji-Yeon Park, Su-Jae Lee, Sang-Gu Hwang. ______________________________________ PS4.6 - DNA Repair 4 PS4074 - Base damage near double-strand break ends affects rejoining efficiency and the chronology of repair events for these lesions

Thursday

PS4069 - Cultured endothelial human cells prematurely enter senescence as a non-cancer effect of high- and low-LET irradiation Lorenzo Manti, Marco Durante, Cecilia Arrichiello, Thilo Elsasser, Giancarlo Gialanella, Mariagabriella Pugliese, Sylvia Ritter, Paola Scampoli, Gianfranco Grossi.

PS4070 - Hyper diploid lymphocytes due to aging in a woman living in the high level natural radiation area in Ramsar, Iran Masako Minamihisamatsu, Akira Furukawa, Mojtaba Saghirzadeh, Reiko Kanda, Tsutomu Sugahara, Isamu Hayata.

Shubhadeep Purkayastha, Kamal Datta, Ronald D. Neumann, Thomas A. Winters. PS4075 - A proteolytic fragment of Cyclin E enhances apoptosis through inhibition of DNA repair by interacting with Ku70 and preventing the recruitment of XRCC4, Ligase IV, and XLF Dragos C. Plesca, Suparna Mazumder, Alex Almasan. PS4076 - The human RAD51AP1/PIR51 protein is required for homologous recombination and genomic stability Claudia Wiese, Torsten Groesser, David W. Collins, Bjorn Rydberg, David Schild. PS4077 - The role of homologous recombinational repair (HRR) in determining radiosensitivity throughout the mammalian cell cycle Paul F. Wilson, John M. Hinz, Salustra S. Urbin, Peter B. Nham, Larry H. Thompson.

PS4081 - Molecular dynamics (MD) simulation of Ku heterodimer with double strand DNA molecule Hirofumi Fujimoto, Miroslav Pinak, Juraj Kotulic Bunta, Toshiyuki Nemoto, Naoko Takada, Hideaki Maekawa, Kozo Tsuchida. PS4082 - Response to the challenging dose of X-rays in lymphocytes of prostate cancer patients and healthy donors Antonina Cabulska-Wasilewska, Zygmunt Dobrowolski, Zofia Rudek, Mateusz Krzysiek, Nazym Balegenowa, Zbigniew Drag, Agnieszka Panek, Stanislaw Krasnowolski, Waclaw Lipczynski, Barbara Dobrowolska. PS4083 - Deletion of histone modifying enzymes Bre1 and Dot1 causes sensitivity to ionizing radiation Kelly E. McCann, Tatiana Spicakova, Marsha Williamson, John C. Game, J. Martin Brown. PS4084 - Ionizing radiation induces microhomology-mediated nonhomologous end joining in yeast and mammalian cells Zorica Scuric, Cecilia Y. Chan, Kurt Hafer, Robert H. Schiestl.

109

Thursday

PS4078 - Molecular basis of radioresistance in glioblastomas: proficient repair of DNA doublestrand breaks in astrocytes expressing egfrviii Bipasha Mukherjee, Cristel Vanessa Camacho, Robert Bachoo, Sandeep Burma. PS4079 - Modulation of the DNA damage response to hze particles by shielding Bipasha Mukherjee, Jack Miller, Sandeep Burma.

PS4080 - Does non-homologous end joining (NHEJ) prevent repair of clustered DNA damages from converting to double strand break (DSB)? Svitlana G. Malyarchuk, Lynn Harrison.

PS4085 - Ionizing radiation and restriction enzymes induce microhomologymediated illegitimate recombination in trans in Saccharomyces cerevisiae Cecilia Y. Chan, Markus Kiechle, Palaniyandi Manivasakam, Robert H. Schiestl. PS4086 - Heterogeneity in the response of the Fanconi Anemia pathway to genotoxic stress Lisa A. Kachnic, Chen-Mei Luo, Li Li, Martin Purschke, Kerstin Borgmann, Kathryn D. Held, Simon N. Powell, Henning Willers. PS4087 - Vitamin D antagonizes radiation-induced expression of Rad51 in head and neck squamous cell carcinoma Christopher A. Bradley, Shey-Jen Shih, Andrew T. Vaughan, Danny J. Enepekides, Gregory Farwell, Joanna S. Albala. PS4088 - Werner Syndrome Protein is phosphorylated by DNA-PK and regulates DNA double-strand break repair Asaithamby Aroumougame, Steven M. Yannone, David J. Chen.

110

PS4090 - Differential expression of DNA repair genes following irradiation of human fibroblast and endothelial cells Swati Girdhani, Amir Abdollahi, Philip Hahnfeldt, Sharon Kunder, Christian Schwager, Ute Wirkner, Peter Huber, Lynn Hlatky. PS4091 - Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine Sophia B. Chernikova, James W. Evans, Lisa A. Kachnic, Judith P. Banath, Olivier Sordet, Yvette M. Delahoussaye, Alejandro Treszezamsky, Brian Chon, Zhihui Feng, Yves Pommier, Peggy L. Olive, Simon N. Powell, J. Martin Brown. PS4092 - Processing of low dose γradiation induced DNA strand breaks in eukaryotic cell lines in vitro: Insight from pGFP transfected SCID and +/+ cells Rajeshwar N. Sharan. ______________________________________ PS4.7 - Experimental Therapeutics 4 PS4093 - Homing of transplanted stem cells in irradiated tissues Mohi Rezvani, Marc Cranfield, Steve Ray, Uday Tirlapur. PS4094 - Bmi1 polycomb gene has a novel radioresistance function in nasopharyngeal carcinoma

Thursday

PS4089 - Mice lacking DNA polymerase POLQ have increased radiationinduced micronuclei in vivo and radiosensitization of marrow stromal cells in vitro Julie P. Goff, Michael W. Epperly, Donna Shields, Tracy Smith, Mineaki Seki, John Wittschieben, Richard D. Wood, Stephen

Dertinger, Dorothea Torous, Joel S. Greenberger.

Nehad M. Alajez, Wei Shi, Angela BY Hui, Fei-Fei Liu. PS4095 - Prx1 interacts with androgen receptor and enhances its transactivation by hypoxia/reoxygenation Soo-Yeon Park, Xiaofei Yu, Clement Ip, James L. Mohler, Paul N. Bogner, Young-Mee Park. PS4096 - Human Prx1 and Prx2 are not duplicative proteins: The unique presence of Cys83 in Prx1 plays a critical role in providing structural and functional differences between Prx1 and Prx2 Yun-Jeong Kim, WeonSup Lee, Kyoung-Soo Choi, Jonah Riddell, Clement Ip, Debashis Ghosh, JongHoon Park, Young-Mee Park. PS4097 - Characterization of spatiotemporal fluctuations in vascular pO2 in three rat tumor lines Laura Isabel Cardenas-Navia, Daniel Mace, Rachel Ann Richardson, Siqing Shan, David F. Wilson, Mark W. Dewhirst.

PS4099 - Tumor pO2 of orthotopic gliomas and their response to irradiation and hyperoxygenation: how this

PS4100 - Modulation of peripheral tumor hypoxia by topical vasodilator (benzyl nicotinate): an EPR oximetry study Huagang Hou, Zrinka Abramovic, Marjeta Sentjurc, Jean P. Lariviere, Hongbin Li, Shiyi Lu, Eugene Demidenko, David J. Gladstone, Harold M. Swartz, Nadeem Khan. PS4101 - Hypoxic and acidic tumor environment markedly alters the radiation-induced gene expression and radiosensitivity of tumor cells Yeon Hee Kook, Hyewon Youn, Eun Taex Oh, Kyung Hee Park, Chang Won Song, Eun Kyung Choi, Byung Uk Lim, Heon Joo Park. PS4102 - Hypoxic induction of neurotensin in lung carcinoma cells: its involvement in a resistance to γ-radiation and anticancer drug Tae Lim Kim, Jee Sun Oh, Kug Chan Kim, Il Lae Jung, Eun Wie Cho, Sang Ki Paik, In Gyu Kim. PS4103 - Radiosensitization by the combination of SR-2508 and paclitaxel in hypoxic human tumor cells in vitro Cheng Jin, Ling Bai, Guozhen Guo. 111

Thursday

PS4098 - Inhibitory effects on tumor growth and suppressive effects on hypoxia of a ribonucleoside anticancer drug, tas106 in xirradiated tumor Hironobu Yasui, Osamu Inanami, Taketoshi Asanuma, Daisuke Iizuka, Akira Matsuda, Mikinori Kuwabara.

information could be potentially used to individualize and optimize radiotherapy Nadeem Khan, Hongbin Li, Huagang Hou, Jean P. Lariviere, Shi Y. Lu, Eugene Demidenko, David J. Gladstone, Julia A. O’Hara, Harold M. Swartz.

PS4104 - Antizyme suppression leads to induction of HIF-1α protein and increment of cellular redox potential in lung carcinoma cells: its involvement in resistant to γradiation Tae Lim Kim, Jin Sik Kim, Sang Gi Paik, Hai Won Chung, In Gyu Kim. PS4105 - Lifespan of Rat-1 fibroblasts overexpressing dominant negative Ku70 under hypoxic conditions Muneyasu Urano, Yun-Fong Huang, Fuqiu He, Clifton Ling, Gloria Li. PS4106 - Using hypoxic hypoglycemia to selectively starve hypoxic cancer cells: influence of hypoxia and glucose availability on glucose consumption and cell survival Thies Schroeder, John P. Kirkpatrick, Mark W. Dewhirst.

PS4109 - Importance of scheduling of anti-VEGFR2 antibody DC101 112

PS4110 - Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression, inhibits angiogenesis and tumor growth Yiting Cao, Pierre Sonveaux, Shanling Liu, Yulin Zhao, Jing Mi, Bryan M. Clary, Chuan-Yuan Li, Christopher D. Kontos, Mark W. Dewhirst. PS4111 - Inhibition of cytosolic phospholipase A2 (cPLA2) leads to decreased function in irradiated vascular endothelium Amanda G. Linkous, Kyle C. Cuneo, Andrej Lyshchik, Dennis E. Hallahan, Eugenia M. Yazlovitskaya. PS4112 - The bone marrow derived myelomonocytic cells restore vasculogenesis in irradiated tumor bed by secreting matrix metalloproteinase-9 G-One Ahn, J. Martin Brown. PS4113 - TNF-alpha-related apoptosisinducing ligand (TRAIL) enhances radiation-induced cell killing in human carcinoma in vitro and in vivo Momoko Takahashi, Osamu Inanami, Mikinori Kuwabara.

Thursday

PS4107 - Short-term effects of a 15Gy 79keV synchrotron tomographic irradiation on healthy mice brain microvasculature Clement Ricard, Jean-Claude Vial, Sonia Teypaz, Jerome Gastaldo, Manuel Fernandez, Francois Esteve, Christoph Segebarth, Boudewijn van der Sanden. PS4108 - Combining antiangiogenic therapy with radiotherapy enhances tumor response without functionally normalizing the tumor vasculature Bruce M. Fenton, Scott F. Paoni.

combined with fractionated irradiation (FXRT) in the treatment of human head and neck carcinoma xenografts Oliver Riesterer, David Valdecanas, Kathy Mason, Walter Hittelman, Daniel Hicklin, Luka Milas, Kian Ang.

PS4114 - Radiosensitization of multicellular tumor spheroids by 2-deoxy-D-glucose is stimulated by a combination of TNFα and glucodeprivation induced oxidative stress Bilikere S. Dwarakanath, Divya Khaitan, Sudhir Chandna. PS4115 - Combining radiation therapy with interstitial radiationinducible TNF-α expression for local regional cancer treatment Mira Jung, Alexandre Dimtchev, Arron Foxworth, Anatoly Dritschilo. ______________________________________ PS4.8 - Radiation Carcinogenesis 4 PS4116 - Differential effect of low and high dose X-rays on mutation induction by N-ethyl-Nnitrosourea in thymocytes of B6C3F1 gpt-delta mice Kazumi Yamauchi, Shizuko Kakinuma, Satomi Sudo, Seiji Kito, Yuki Oota, Takehiko Nohmi, Kenichi Masumura, Mayumi Nishimura, Yoshiya Shimada.

PS4118 - Radiation increases the outgrowth of p16INK4a(-) human

PS4119 - Identification of radiation specific gene signatures in rat mammary tumors Hae-June Lee. PS4120 - ROS levels and mutations in atrophic thymuses after γirradiation Ryo Kominami, Hiroyuki Ohi, Masaki Maruyama, Kenya Kamimura, Yukio Mishima, Ohtsura Niwa. PS4121 - Distinct structural abnormalities of chromosomes 11 and 12 associated with loss of heterozygosity in X-ray-induced mouse thymic lymphomas Akifumi Nakata, Mitsuaki A. Yoshida, Miho Akiyama, Shizuko Kakinuma, Toshihiko Sado, Mayumi Nishimura, Yoshiya Shimada. PS4122 - Influence of genetic background on hair-cycle dependent basal cell carcinoma tumorigenesis in irradiated Ptc1+/- mice Mariateresa Mancuso, Simona Leonardi, Mirella Tanori, Emanuela Pasquali, Simonetta Rebessi, Vincenzo Di Majo, Simonetta Pazzaglia, Anna Saran. PS4123 - Sex- and tissue- specific microRNAome changes upon irradiation in a mouse model

113

Thursday

PS4117 - Leukemogenesis and early loss of PU.1 on chromosome 2 in CBA/CaJ and C57BL/6 mice after irradiation with HZE iron ions Yuanlin Peng, Christy L. Warner, Xianan Liu, Paula C. Genik, Matthew A. Callan, F. Andrew Ray, Michael M. Weil, Robert L. Ullrich, Joel S. Bedford.

mammary epithelial cells in serumfree cultures Rituparna Mukhopadhyay, Alexey Bazarov, William C. Hines, Mary Helen Barcellos-Hoff, Paul Yaswen.

Yaroslav Ilnytskyy, Olga Kovalchuk. PS4124 - Combined effects of radiation and estrogen on the epigenetic processes in rat mammary gland Kristy Kutanzi, Igor Koturbash, Rocio Rodriguez-Juarez, Olga Kovalchuk. PS4125 - The irradiated stroma increases tumors arising from nonirradiated, p53 null mammary epithelium David H. Nguyen, Hellen A. Oketch-Rabah, Daniel Medina, Mary Helen Barcellos-Hoff. ______________________________________ PS4.9 - Radioprotectors/Mitigators 4 PS4126 - Study on radiation-induced adaptive response in fetal mice Bing Wang, Kaoru Tanaka, Yi Shang, Guillaume Vares, Yasuko Morimoto, Tetsuo Nakajima, Mitsuru Nenoi, Isamu Hayata. PS4127 - Adaptive response in embryogenesis: comparative microarray analysis of gene expressions in mouse fetuses Guillaume Vares, Bing Wang, Yi Shang, Harumi Ohyama, Kaoru Tanaka, Tetsuo Nakajima, Mitsuru Nenoi, Isamu Hayata.

114

PS4129 - Radiation-induced changes in vasoconstriction of rat pulmonary arteries to angiotensin II are mitigated by captopril Rong Zhang, Ying Gao, Swarajit Ghosh, John Moulder, Brian Fish, Elizabeth Jacobs, Meetha Medhora. PS4130 - Evaluation of carnosine as a radiation countermeasure agent Theodor A. Zainal, Venkataraman Srinivasan, Mark H. Whitnall. PS4131 - Exploring mechanisms for the efficacy of ACE inhibitors and AII blockers in radiation nephropathy John E. Moulder, Brian L. Fish, Amy A. Irving, Marylou Mader, Eric P. Cohen. PS4132 - Ramipril mitigates radiationinduced impairment of dentate gyrus neurogenesis Kenneth A. Jenrow, Jianguo Liu, Andrew Kolozsvary, Stephen L. Brown, Jae Ho Kim. PS4133 - Ramipril mitigates whole brain radiation injury observed by contrast enhanced MRI Stephen L. Brown, James R. Ewing, Sanath Kumar, Swayamprava Panda, Kenneth A. Jenrow, Joseph D. Fenstermacher, Tavarekere N. Nagaraja, Andrew Kolozsvary, Kelly Ann Keenan, Jae Ho Kim. PS4134 - Defined doses of the radioprotectors amifostine and

Thursday

PS4128 - Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein Cindependent mechanism

Junru Wang, Marjan Boerma, Qiang Fu, Louis M. Fink, Martin HauerJensen.

phosphonol protect against chromosomal inversion in pKZ1 spleen Antony M. Hooker, David J. Grdina, Madhava Bhat, Pamela J. Sykes. PS4135 - ACE inhibition immediately following irradiation may increase GI morbidity and mortality Mary F. Otterson, Shawn Leming, Jennifer Callison, John E. Moulder, Parvaneh Rafiee. PS4136 - Amifostine modulates lethal and non-lethal toxicities induced in mice by gamma-ray and neutron exposure Tatjana Paunesku, David Paunesku, Andrew Wahl, Yasushi Kataoka, David Grdina, Gayle E. Woloschak. PS4137 - Amifostine metabolite WR-1065 mitigates high and low LET radiation-induced genomic instability Janet E. Baulch, Jaroslaw Dziegielewski, Jeffrey S. Murley, David J. Grdina, William F. Morgan. PS4138 - Epithelial mesenchymal transition (emt) in radiation (rt) induced pulmonary fibrosis Isabel Jackson, Vasily Yakovlev, Ross Mikkelsen, Mitchell S. Anscher, Zeljko Vujaskovic.

PS4140 - Radioprotection of murine hematopoietic and human bone marrow cells by Ex-Rad, ON 01210.Na, a novel radiation protectant Stephen C. Cosenza, A Kang, M Bonagura, M V. Reddy, M Maniar, A A. Alfieri, S Ghosh, K S. Kumar, E P. Reddy. PS4141 - Radioprotective effect of zinc yeast is P53 dependent manner to human lymphoblastoid cells Yoshihiro Fujii, Takamitsu A. Kato, Akira Fujimori, Nobuo Kubota, Ryuichi Okayasu. PS4142 - Modulation of radiation induced haematological alterations in swiss albino mice by brassica compestris (var sarason) seed extract Anil K. Soni, Manish Kumar, Shalini Shukla, Punar Dutt Meena, Madhu Kumar, Ashok Kumar. PS4143 - Biomimetic lanthanide & actinide decorporation agents: preclinical development Patricia W. Durbin, Eleanor A. Blakely, David K. Shuh, Polly Y. Chang, Kenneth N. Raymond. PS4144 - Cytokine expression after 5androstenediol administration and gamma-irradiation in mouse hematopoietic tissues in vivo 115

Thursday

PS4139 - CBLB600s: a family of novel compounds with radioprotective and hematopoetic stem cells stimulating activity, acting via

activation of TLR2 receptor complexes Frederic Bone, Eugenia Strom, Jason Young, Yevgeniy Kononov, Andrei Gudkov, Elena Feinstein, Alexander Shakhov.

Vijay K. Singh, Marcy B. Grace, Kenneth O. Jacobsen, Cheng-Min Chang, Vaishali I. Parekh, Cynthia E. Inal, Randi L. Shafran, Alexander D. Whitnall, Tzu-Cheng Kao, William E. Jackson, Mark H. Whitnall. ______________________________________ PS4.10 - Signaling 4 PS4145 - Metastasis dissemination is mediated by CXCR4 receptor in HPV/E6+ cells and can be therapeutically controlled by combination of Cidofovir with irradiation Amine Abdessamad. PS4146 - U87 glioblastoma cells are radiosensitized by double transfection with EGFR and PTEN Phyllis R. Wachsberger, Rochelle Halko, Lindsay Uribe, Paul Mischel, Adam P. Dicker. PS4147 - Spatio-temporal responses to different UV wavelengths in human skin organ culture Eiichiro Mori, Akihisa Takahashi, Ken Ohnishi, Yoshiya Furusawa, Takeo Ohnishi. PS4148 - PPARs reduction by γirradiation as a mechanism to inflammatory and immune process in rat colon Christine Linard, Marc Benderitter.

PS4150 - Possible intervention strategies to reduce the initiation and progression of radiation-induced atherosclerosis Saske Hoving, Sylvia Heeneman, Hans te Poele, Jeffrey Pol, Nicola Russell, Marion Gijbels, Mat Daemen, Fiona Anne Stewart. PS4151 - Characterization of the role for p38 MAP kinase in the in vivo radiation-induced inflammatory response Henghong Li, Hukjin Cha, Dmitry V. Bulavin, Albert Fornace. PS4152 - Molecular crosstalk between PIKK and MAPK in cellular response to ionizing radiation Yanrong Su, Jarah A. Meador, Adayabalam S. Balajee. PS4153 - Identification and characterization of factors involved in delayed effects of radiation David L. Springer, Jonathan S. Peters, Cheryl L. Baird, Donald S. Daly, Ronald J. Moore, Jin Shuangshuang, William F. Morgan, John H. Miller. PS4154 - Impact of partial marrow sparing on plasma inflammatory molecules after total body irradiation Paul Okunieff, Weimin Sun, Shanmin Yang, Hengshan Zhang, Wei Wang, Chaomei Liu, Mei Zhang, Steven Swarts, Bruce Fenton, Lurong Zhang, Paul Okunieff.

Thursday

PS4149 - Analysis of crosstalk between low-dose-radiation-induced signaling and insulin signaling in human breast cancer cells 116

Tetsuo Nakajima, Mitsuru Nenoi.

PS4155 - Biomarkers of radiation exposure: ex vivo, in vitro and in vivo studies Karen Thomas, Paul Babyn, Diana Wilkinson, Wendy Doda, Hillary Boulay, Louise Prud’hommeLalonde, Sylvie Lachapelle, Sami Qutob, Stacey Gibson, Louise Lemyre. PS4156 - Role of TNF-alpha in radiationinduced bystander effects Vladimir N. Ivanov. PS4157 - Proton radiation induced fibrosis: effects of protein kinase C on integrin expression Pinal R. Pandya, Virginia GC Serra, Leticia S. Ortloff, Lora M. Green. PS4158 - Radiation-induced sialyltransferase involves in radioresistance Minyoung Lee. PS4159 - The chemopreventive agent Curcumin, is a potent radiosensitizer of human cervical tumor cells by a mechanism that involves increased ROS production and overactivation of the MAPK pathway Prashanthi Javvadi.

PS4162 - Transcriptional regulation of endothelial cell thrombomodulin by statins Qiang Fu, Junru Wang, Marjan Boerma, Xiaohua Qiu, Louis M. Fink, Martin Hauer-Jensen. PS4163 - Involvement multiple factors in regulation of the CDKN1A gene promoter in response to ionizing radiation Mitsuru Nenoi, Kazuhiro Daino, Tetsuo Nakajima, Keiko Taki, Ayana Kakimoto. PS4164 - Role of the WW binding motif of the EGR-1 in its binding and transactivation function Anna Reeves, Marius Sudol, Mark Bedford, Mohammed Momin Shareef, Mansoor M. Ahmed. PS4165 - Gene expression in the spleen of mice after irradiation with middledose-rate γ-rays Takashi Sugihara, Hayato Murano, Kimio Tanaka, Yoichi Oghiso. PS4166 - Nf-κB-mediated her-2 overexpression promotes radioresistance Ning Cao, Ming Fan, Kazi Mokim Ahmed, Jian Jian Li.

117

Thursday

PS4160 - Molecular switches of the cytogenetic radioadaptive response in human cells Francesco Marchetti, Sanchita Bhattacharya, Matthew A. Coleman, Andrew J. Wyrobek.

PS4161 - Transcriptional analysis of the effect of ionising radiation at the gastrula stage Abderrafi Benotmane, Arlette Michaux, Ann Janssen, Jasmine Buset, Mieke Neefs, Paul Jacquet.

PS4167 - Analysis of gene expression profiles in mice exposed to lowdose rate radiation Keiko Taki, Bing Wang, Tetsuo Nakajima, Jianyu Wu, Tetsuya Ono, Tsuneya Matsumoto, Yoichi oghiso, Kimio Tanaka, Kazuaki Ichinohe, Shingo Nakamura, Satoshi Tanaka, Mitsuru Nenoi.

PS4171 - Dosimetric evidence of cell extra nuclear sensitivity to alpha irradiation? Nicolas Chouin, Manuel Bardias, Michel Cherel, Alain FaivreChauvet, Christos Apostolidis, Alfred Morgenstern, Albert Lisbona, Jacques Barbet, Karine Bernardeau, Francois Davodeau.

PS4168 - Single versus fractionated doses of radiation lead to differences in gene expression in human tumor cell lines John A. Cook, Mong-Hsun Tsai, Gadisetti V.R. Chandramouli, William DeGraff, C. Norman Coleman, Eric Y. Chuang, James B. Mitchell.

PS4172 - Mechanisms of adaptive response induction by low dose and low dose rate: modeling approach Olga A. Smirnova.

PS4169 - Low-dose rate photons and simulated solar particle event protons: gene expression in liver Daila S. Gridley, Asma Rizvi, Adeola Y. Makinde, Xian Luo, Jian Tian, Melba Andres, George B. Coutrakon, Michael J. Pecaut.

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PS4174 - Effects of X-ray micro beam irradiation on the function of neuronal network Takahiro Kuchimaru, Fuminobu Sato, Tomohisa Fujita, Toshiji Ikeda, Kikuo Shimizu, Yushi Kato, Toshiyuki Iida. PS4175 - New perspectives in modeling of carcinogenesis induced by ionizing radiation Igor Akushevich, Galina Veremeeva, Aliaksandr Kulminski, Svetlana Ukraintseva, Konstantin Arbeev, Alexander Akleyev, Anatoli Yashin. PS4176 - Auger electron therapy Rebecca Hinrichsen, Helge Thisgaard, Mikael Jensen, Michael Lyngkjær, Lars Martiny.

Thursday

PS4170 - Modulation of nuclear factor kappa B dependent gene expression in human cells after microbeam irradiation with accelerated alpha particles Christa Baumstark-Khan, Christine E. Hellweg, Luis F. Spitta, Andrea Arenz, Roland Ruscher, KlausDieter Greif, Ulrich Giesen, Guenther Reitz. ______________________________________

PS4173 - Three-dimensional model of tissue and heavy ions effects Artem L. Ponomarev, Alamelu Sundaresan, Janice L. Huff, Francis A. Cucinotta.

PS4177 - Automatic unstained cells recognition for single-cell irradiations Marcin Skoczylas, Roberto Cherubini, Silvia Gerardi. PS4178 - New improvements of the Krakow single ion hit facility for cells irradiation Oleksandr Veselov, Janusz J. Lekki, Rasa Ugenskiene, Zbigniew Stachura, Kateryna Lebed, Wojciech M. Kwiatek. PS4179 - A fast analytical model for assessing biological effectiveness of light ion beams in radiotherapy Pavel Kundrat. PS4180 - Podcasting information in the radiological sciences to health care professionals Carl D. Elliston, David J. Brenner, Nitin Gumaste, John Zimmerman, Eric J. Hall.

PS4181 - Characterization of a pre-cell hit detector to be used in single cell irradiation experiments at the Lund Nuclear Microprobe Charlotta Nilsson, Jan Pallon, Goran Thungstrom, Natalia Arteaga-Marrero, Mikael Elfman, Per Kristiansson, Christer Nilsson, Marie Wegden. PS4182 - Monte Carlo Microdosimetry for targeted Irradiation of Individual cells using a microbeam facility Fredrik L. Andersson, Sebastien Incerti, Odile Boissonade, Philippe Barberet, Carlos Furtado, Claire Habchi, Philippe Moretto, Duy Thuy Nguyen, Thomas Pouthier, Hervé Seznec. PS4183 - Development of nanotechnology based high spatial and temporal resolution cellular and small animal irradiation systems Sha X. Chang, Jian Zhang, Sigen Wang, David Bordelon, Eric Schreiber, Sarah Graboski, Adrienne D. Cox, Otto Zhou.

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