JOURNAL TRANSCRIPT

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THURSDAY, FEBRUARY 27 AND FRIDAY, FEBRUARY 28 Thursday, February 27

3:45

Military Allergy Program

4:00

0001 28th Annual Harold S. Nelson Military Allergy/ Immunology Symposium

4:15

8:00 9:00 9:30 9:50

10:10

10:30

10:50

11:10

11:30

1:00

1:20

1:40

2:00 2:30 3:00

3:30

7:20 am to 5:00 pm Convention Center, Upper Level, Room 3 Pre-registration and ticket required. No fee for approved and registered military members. $60 fee for non-military members. Continental breakfast and box lunch included. Credit: 7.00 CME / 8.00 CE Moderator: Kimberly S. Johnson, MD Kimberly S. Johnson, MD Morning Address: Dermatology for the Military Allergist Timothy Straight, MD PhD Break Fellow Original Research Safety of Cluster Allergen Immunotherapy During Refill Dosing Tiffany J. Owens, MD Demographics and Retention Patterns for 1999-2011 U.S. Air Force Allergy Graduates Michelle Bandino, MD Serologic Specific IgE (sIgE) Testing in a Closed Healthcare System Daniel A. Steigelman, MD Safety and Efficacy of a 12-Week Maintenance Interval in Patients Treated With Imported Fire Ant Immunotherapy Karla E. Adams, MD Staff Original Research Vitamin D Supplementation Improve Urticaria Symptoms in Adult Chronic Urticaria Tadech Boonpiyathad, MD Increased Respiratory Illness and Transient Immune Alterations Seen with Multiple Vaccinations Administered in a Stressful Environment Rachel Umi Lee, MD FAAAAI Lunch and Bruton Lecture: Treatment Options for Refractory Urticaria David A. Khan, MD FAAAAI Fellow Case Reports Selective IgM Deficiency Presenting as Cryptogenic Organizing Pneumonia Cory A. Lundberg, DO A Devastating Outcome in Undiagnosed X-Linked Agammaglobulinemia: A Call for Earlier Screening Karen Elizabeth Bruner, MD Intractable Burkholderia Vietnamiensis and Hemophagocytic Lymphohistiocytosis in Homozygous Interleukin-12 Receptor Beta-1 Deficiency Ki Lee Milligan, MD Break Vaccine Healthcare Center Update Limone C. Collins Jr., MD Military Aeroallergen Extract Laboratory Updates Susan E. Kosisky, BS MHA Consultants to the Surgeons General Updates: VHA Allergy Committee Joseph S. Yusin, MD FAAAAI

Allied Health Session

ticket required

fee required

4:30

Air Force Kevin M. White, MD Army Michael R. Nelson, MD PhD FAAAAI Navy Michael R. Kaplan, DO FAAAAI Business Meeting and Award Presentations

Upon completion of this session, participants should be able to: Discuss the approach to identifying allergic skin disorders in the military environment and the role of biopsy in the diagnosis and management; Identify the differential diagnosis of chronic urticaria and explain the diagnostic approach; Discuss the application of novel therapy in the treatment of chronic urticaria.

Fellows-In-Training and New Allergist/Immunologist Assembly Joint Reception 7:00 to 8:00 pm Marriott North Tower, Lobby Level, Rancho Santa Fe 1-3 Reception is open to current Chrysalis participants, FITs and NAIA members.

Friday, February 28 Fellows-in-Training Program 1011 FIT Symposium

7:00 8:00

8:05 8:15 8:20 8:50 9:20 9:35 9:45 10:15 10:45 11:15 11:45 12:15 1:00

7:00 am to 2:00 pm Marriott North Tower, Lobby Level, San Diego Ballroom Salon B Pre-registration and ticket required. No fee. Continental breakfast and box lunch included. Credit: No CME / No CE Networking Breakfast Introductions Taylor A. Banks, MD Mary Beth Fasano, MD FAAAAI Networking Organizations American Board of Allergy and Immunology Stephen I. Wasserman, MD FAAAAI Allergy Immunotherapy: The Basics Michael R. Nelson, MD PhD FAAAAI Immunotherapy Extracts Robert G. Hamilton, PhD D.ABMLI FAAAAI Break Welcome from the AAAAI President Linda Cox, MD FAAAAI Immunotherapy: New and Emerging Issues Linda Cox, MD FAAAAI Immunomodulation with Immunotherapy Joann C. Blessing-Moore, MD FAAAAI Pearls and Pitfalls of Diagnostic Testing Michael S. Blaiss, MD FAAAAI Venom Immunotherapy David B.K. Golden, MD FAAAAI Difficult AIT Cases David A. Khan, MD FAAAAI Networking Lunch AIT Prescription Workshop

Upon completion of this session, participants should be able to: Describe the pathophysiology, initial evaluation and management of patients with allergies to aeroallergens and/or venoms; Identify recent advances in the field of immunotherapy, including mechanisms of immunomodulation; Discuss current and emerging treatment modalities and adjuncts in the management of aeroallergen and venom allergic patients.

included in the Virtual Annual Meeting

25

FRIDAY, FEBRUARY 28 1101D Differentiating Asthma From COPD: Why is This So Hard?

Allied Health Course 1101 Advanced Practice Course

8:00 8:15

9:00 9:45 10:00 10:45 11:30 12:15

8:00 am to 12:30 pm Marriott North Tower, Lobby Level, Marriott Hall Salons 1 & 2 Pre-registration and ticket required. No fee. Credit: 4.50 CME / 5.40 CE Moderators: Nina A. Zimmermann, MSN RN ANP-BC AE-C Debra A. Sedlak, MSN CPNP Introduction Debra A. Sedlak, MSN CPNP Patients’ Attitudes and Beliefs About Complementary and Alternative Medicine Use for Asthma Self-Management Maureen George, PhD RN AE-C FAAN Bronchial Thermoplasty for the Treatment of Severe Asthma Mario Castro, MD MPH Question & Answer Vitamin D: Sunlight at the End of the Tunnel Nicolette De Jong, PhD Food Allergy: New Therapies on the Horizon Beth D. Strong, RN CCRC Managing Atopic Dermatitis: Itching the Night Away! Karol G. Timmons, RN MS CPNP Question & Answer

Upon completion of this session, participants should be able to: Evaluate how patients' health beliefs impact asthma self-management; Identify asthma patients who may benefit from alternative treatments such as broncial thermoplasty and Vitamin D therapy; Define new and appropriate treatment strategies for common food allergies and atopic dermatitis.

Allied Health Advanced Practice Course Breakout Sessions 12:30 to 2:00 pm Separate pre-registration, ticket and fee from the 1101 Advanced Practice Course. Pre-registration and ticket required. Fee: $20. Box lunch included. Sessions and meals are limited to registered attendees. Credit: 1.50 CME / 1.80 CE

1101A Cough/Chronic Cough Marriott North Tower, Lobby Level, Marriott Hall Salon 5 Nina A. Zimmermann, MSN RN ANP-BC AE-C Jeanette L. Arnold, MSN RN C-FNP Upon completion of this session, participants should be able to discuss the diagnostic evaluation and therapeutic options to treat chronic cough.

1101B Is This Anaphylaxis? Marriott North Tower, Lobby Level, Marriott Hall Salon 6 Gabriel Ortiz, MPAS PA-C DFAAPA Vivian P. Hernandez-Trujillo, MD FAAAAI

Upon completion of this session, participants should be able to identify differences and similarities in patients with asthma vs. COPD.

Clinical Research Workshop 1102 The Anatomy of the Clinical Trial Agreement 8:00 to 9:15 am Marriott North Tower, Lobby Level, Torrey Pines 1 & 2 Credit: 1.25 CME / 1.50 CE Moderator: Christopher Chang, MD PhD FAAAAI The Anatomy of the Clinical Trial Agreement and Negotiating a Profitable Budget Cheryl Koff Bernstein, RN BSN CCRC Upon completion of this session, participants should be able to: Identify and discuss the language used in reciprocal or crossed indemnification and offer alternative indemnification language during contract negotiations; Identify and discuss important sections of the contract such as liability insurance, language used to describe adherence to the protocol, payment, study termination and offer alternative language; Discuss successful methods and techniques used during contract and budget negotiations with the sponsor.

Chrysalis Project 1111 2014 Chrysalis Project Program

7:30 8:00

8:05 8:15 8:45 9:15 9:45 10:00 10:30

Upon completion of this session, participants should be able to describe anaphylaxis and the initiation of appropriate treatment.

11:00

1101C Opening Pandora’s Box: Asking the Right Questions

11:20

Marriott North Tower, Lobby Level, Torrey Pines 1 & 2 David Wayne Unkle, MSN APN FCCM Anthony J. Ricketti, MD FACAI FCCP Upon completion of this session, participants should be able to discuss strategies for interpreting information given by our patients.

26

Marriott North Tower, Lobby Level, Atlanta & Chicago Edward O. Corazalla, MS RPFT Karen L. Gregory, DNP APRN-BC RRT AE-C

11:40 12:00

Allied Health Session

7:30 am to 2:00 pm Marriott North Tower, Lobby Level, Rancho Santa Fe 1-3 Pre-registration and ticket required. No fee. Continental breakfast and box lunch included. Credit: No CME / No CE Breakfast Welcome Thomas A. Fleisher, MD FAAAAI Kimberly A. Risma, MD PhD FAAAAI Welcome from the AAAAI President Linda Cox, MD FAAAAI Food Allergy A. Wesley Burks, MD FAAAAI Eosinophilic Disorders Paneez Khoury, MD Immunodeficiency Kathleen E. Sullivan, MD PhD FAAAAI Break Asthma Rohit Katial, MD FAAAAI Atopic Dermatitis Donald Y.M. Leung, MD PhD FAAAAI Academic Career Paths Kimberly A. Risma, MD PhD FAAAAI Industry Career Paths Daniel C. Adelman, MD FAAAAI Private Practice Career Paths Adina Kay Knight, MD FAAAAI Chrysalis Project Program Luncheon with FIT Mentors

ticket required

fee required

included in the Virtual Annual Meeting

FRIDAY, FEBRUARY 28 Program Directors Course

Course

1112 How to Develop and Maintain Excellence in Allergy/Immunology Fellowships: Boot Camp for Program Directors and Clinical Faculty

1202 NIAID: Epigenetics in Asthma and Allergy: Basic Concepts and Recent Advances

8:15 8:45

9:15

9:45

10:15 10:30 11:00 11:30

8:15 am to 12:00 pm Marriott North Tower, Lobby Level, San Diego Ballroom Salon A Pre-registration and ticket required. No fee. Continental breakfast included. Credit: No CME / No CE Moderator: Asriani M. Chiu, MD FAAAAI Continental Breakfast The ABC’s of Post-Graduate Medical Education (AAAAI, ABAI, ACGME) and Beyond Mary Beth Fasano, MD FAAAAI The Nuts and Bolts of Building an A/I Fellowship Program: Program Requirements in the Era of the Next Accreditation System Jeffrey R. Stokes, MD FAAAAI Communications and Reference Tools: iPads, iPhones and PubMed Thanai Pongdee, MD FAAAAI Break How to Use the Milestones for Effective Learner Assessment Michael R. Nelson, MD PhD FAAAAI Curriculum Design: Tips for Teaching Generation Y Fanny Silviu-Dan, MD FAAAAI Directing an A/I Fellowship Program: Ask the Expert Panel Discussion Mariana C. Castells, MD PhD FAAAAI Lawrence B. Schwartz, MD PhD FAAAAI Elizabeth A. Secord, MD FAAAAI

Upon completion of this session, participants should be able to: Enhance the teaching skills of upcoming, new and current allergy/immunology fellowship program directors and associate program directors, core A/I fellowship faculty and community volunteer clinical faculty; Provide practical tips for developing and enhancing an A/I fellowship program in the context of the next accreditation system; Support the development of allergy/immunology program directors, fellowship core faculty and community volunteer clinical faculty; Improve the quality of allergy/immunology fellowship training.

1201 Advanced Course in Pollen Identification

9:30 10:00 10:30 11:00 11:30

9:25 9:50 10:15 10:30

10:55 11:20

11:45

Upon completion of this session, participants should be able to: Describe the importance of epigenetic changes and their potential impact on our understanding and treatment of allergic diseases and asthma; Identify specific cells and pathways relevant to allergy and asthma where epigenetic changes may influence disease.

Course 1203 Technology in the Clinical Practice Made Ridiculously Simple

9:00 9:20

Course

9:00

9:00

9:00 am to 12:00 pm Marriott North Tower, Lobby Level, Marriott Hall Salon 3 Pre-registration and ticket required. Fee: $125. Credit: 3.00 CME / 3.60 CE Moderator: Estelle Levetin, PhD FAAAAI Asteraceae Pollen Peter Van De Water, PhD Hands-On Instruction; Question & Answer Betulaceae Pollen Richard W. Weber, MD FAAAAI Hands-On Instruction; Question & Answer Other Triporate and Tricolporate Pollen Estelle Levetin, PhD FAAAAI Hands-On Instruction; Question & Answer

9:00 am to 12:00 pm Convention Center, Upper Level, Room 11AB Credit: 2.75 CME / 3.30 CE Moderator: Alkis Togias, MD FAAAAI Epigenetics: Basic Concepts Bing Ren, PhD Asthma and Allergy Epigenetics: What Have We Learned So Far? David A. Schwartz, MD Environmental Influences on the Epigenome Rachel L. Miller, MD FAAAAI Break Epigenetic Regulation of the Immune System in Relation to Allergy and Asthma Kari C. Nadeau, MD PhD FAAAAI The Epithelial Cell Epigenome and its Relation to Asthma Carole Ober, PhD Epigenetic Regulation of Arachidonic Acid Metabolism and its Clinical Implications Benjamin A. Raby, MD MPH Question & Answer

9:50 10:20 10:30 11:00 11:30 11:50

9:00 am to 12:00 pm Convention Center, Mezzanine Level, Room 14AB Credit: 3.00 CME / 3.40 CE Moderator: Tao T. Le, MD MHS FAAAAI What Can Technology Do for Your Practice Tao T. Le, MD MHS FAAAAI EHRs and the Meaningful Use of Life A. Sean McKnight, MD FAAAAI Practice Management Systems and Other Office Automation Tools Linda D. Green, MD FAAAAI Break iPhones, iPads, Androids, Oh My! Melinda M. Rathkopf, MD FAAAAI Social Media Tools for Marketing and Communications Ves Dimov, MD Making the Technology Work and Pay Off David J. Shulan, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Describe EHRs, practice management systems and office automation technologies appropriate for the clinical practice; Explain the role of mobile technologies in the practice; List web and social media tools for practice marketing and communications.

Upon completion of this session, participants should be able to: Differentiate pollen in the birch family and related tri-porate pollen types; Recognize difficult tricolporate pollen types; Differentiate asteraceae pollen other than ragweed.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

27

FRIDAY, FEBRUARY 28 Course

Course

1204 Endoscopic Evaluation and Management of Chronic Rhinosinusitis (Pre- and Post-Surgery) Including Cultures

1206 Primary Immunodeficiency Diseases: What Do I Do with My Patient? From Start to Finish

9:00 9:20 10:00

10:20 10:30 10:50 11:10

9:00 am to 12:00 pm Convention Center, Upper Level, Room 3 Pre-registration and ticket required. No fee. Credit: 3.00 CME / 3.40 CE Moderator: Anju T. Peters, MD FAAAAI Anatomy of the Sinuses Todd T. Kingdom, MD Radiology of the Sinuses S. James Zinreich, MD Endoscopic Evaluation of the Sinuses Including Cultures: Video and Lecture Wellington S. Tichenor, MD FAAAAI Break Surgical Evaluation Robert C. Kern, MD Endoscopic Evaluation of the Sinuses: Post-Surgical Wellington S. Tichenor, MD FAAAAI Case Management Studies: Question & Answer Daniel L. Hamilos, MD

Upon completion of this session, participants should be able to: Describe the anatomy of the paranasal sinuses and identify pathology on CT scan; Recall indications for surgery and complications of surgery; Perform endoscopy in patients with CRS as well as cultures of the middle meatus and/or sinuses and review management of complicated sinusitis.

Course

9:00 9:25 9:50 10:15 10:35 10:50 11:15 11:40

Upon completion of this session, participants should be able to: Describe a general approach to a patient with recurrent infections or other presentation consistent with PID; Discuss the stepwise approach to the diagnosis of PID and how to apply advanced and specialized tests, possibly in conjunction with guidance from a tertiary provider; List the different modalities available for therapy, general principles of their application and resources for guidance in unusual or complex situations.

Course 1207 Drug Hypersensitivity

1205 Difficult Cases (Part 1)

9:00

9:35

10:10 10:30

11:05

11:40

9:00 am to 12:00 pm Convention Center, Upper Level, Ballroom 6CF Credit: 2.75 CME / 3.30 CE Moderator: Lisa J. Kobrynski, MD MPH FAAAAI Who Needs Evaluation for Immunodeficiency? M. Teresa De La Morena, MD Assessing Innate and Adaptive Humoral Immunity Francisco A. Bonilla, MD PhD FAAAAI Assessing Innate and Adaptive Cellular Immunity I. Celine Hanson, MD FAAAAI Question & Answer Break Therapies for Innate and Adaptive Humoral Immunodeficiency Vincent R. Bonagura, MD FAAAAI Therapies for Innate and Adaptive Cellular Immunodeficiency Mark Ballow, MD FAAAAI Question & Answer

9:00 am to 12:00 pm Convention Center, Mezzanine Level, Room 15AB Pre-registration and ticket required. No fee. Credit: 2.75 CME / 3.20 CE Moderators: David W. Hauswirth, MD FAAAAI Joyce E. Yu, MD Hypereosinophilic Disorders (Not EoE) Amy D. Klion, MD Princess U. Ogbogu, MD FAAAAI Itching Without Rash Cem Akin, MD PhD FAAAAI Gerald B. Lee, MD Break Peri-Operative Anaphylaxis Phillip L. Lieberman, MD FAAAAI Joel M. Hartman, MD What the Allergist/Immunologist Sees That is Not Allergy Dennis K. Ledford, MD FAAAAI Eugene M. Choo, MD FAAAAI Question & Answer

9:00

9:50 10:05 10:55 11:45

9:00 am to 12:00 pm Convention Center, Upper Level, Ballroom 6DE Credit: 2.75 CME / 3.30 CE Moderator: Rebecca S. Gruchalla, MD PhD FAAAAI Symptoms and Skin Testing for Type I Chemotherapy Drug Hypersensitivity David E. Sloane, MD Break Patch Testing in Drug Allergy Antonino G. Romano, MD Antibiotic Skin Testing Anahita F. Dioun, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: List the symptoms of Type I drug hypersensitivity reactions; Identify symptoms of Type IV drug hypersensitivity reactions; Describe diagnostic tools for Type I and Type IV drug hypersensitivity reactions.

Upon completion of this session, participants should be able to discuss diagnostic and clinical management challenges encountered in allergy, asthma and immunology practice.

28

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

FRIDAY, FEBRUARY 28 1209A/D Hands-On Workshop: Allergy Skin Testing

Course

Convention Center, Upper Level, Room 32AB Credit: 1.00 CME / 1.20 CE Peter S. Creticos, MD FAAAAI Jay A. Lieberman, MD John Oppenheimer, MD FAAAAI Anita Trikha, MD

1208 Dermatology for the Allergist: Diagnosis and Therapeutics Boot Camp

9:00

9:30 10:00 10:10 10:20 11:00

9:00 am to 12:00 pm Convention Center, Mezzanine Level, Room 16AB Pre-registration and ticket required. No fee. Credit: 3.00 CME / 3.40 CE Moderator: Lynda C. Schneider, MD FAAAAI Common Dermatologic Diseases with Mimics and Crossovers in Allergy: Overview from a Dermatology Perspective Peter A. Lio, MD Therapies for Dermatitis Lawrence F. Eichenfield, MD Question & Answer Break Video Demonstration: Biopsies, Scrapings and Patent Testing Lawrence F. Eichenfield, MD Hands-On Learning Lawrence F. Eichenfield, MD Luz S. Fonacier, MD FAAAAI Peter A. Lio, MD

Upon completion of this session, participants should be able to: Discuss common diagnostic tests applicable to eczemas; Outline basic skin care for allergic skin diseases and avoidance of pitfalls.

Course

Upon completion of this session, participants should be able to: Compare the different devices and other equipment and their characteristics; Explain the importance of standardized allergen extracts for the test result; Demonstrate the importance of standardized testing technique and its control by proficiency testing.

1209B/C Coding and Regulatory Issues Related to Allergy Diagnosis and Treatment Convention Center, Upper Level, Room 33AB Credit: 1.00 CME / 1.20 CE Donald W. Aaronson, MD FAAAAI David A. Brown, MD Gary N. Gross, MD FAAAAI Upon completion of this session, participants should be able to apply adequately the coding, documentation and regulatory guidelines for immunotherapy.

Course 1210 Principles of Healthy Homes: What to Look for and How to Help Your Patients or Evaluation and Mitigation

1209 Allergen Immunotherapy: The Nuts and the Bolts (Part 1)

9:00

9:30

9:00 to 10:00 am Convention Center, Upper Level, Room 30CDE Pre-registration and ticket required. No fee. Credit: 1.00 CME / 1.20 CE Moderator: Matthew A. Rank, MD FAAAAI Advances in Allergy Diagnostic Testing: Component Resolved Diagnosis to Identify Specific Allergens Joerg R. Kleine-Tebbe, MD FAAAAI Food Immunotherapy: Baked, Shaken or Stirred: Is it Ready to be Served? Robert A. Wood, MD FAAAAI

9:00 9:30 10:00 10:15 10:45

9:00 am to 12:00 pm Convention Center, Upper Level, Room 33C Pre-registration and ticket required. No fee. Credit: 2.75 CME / 3.30 CE Moderator: Jay M. Portnoy, MD FAAAAI The Indoor Biome and Healthy Housing Christina E. Ciaccio, MD FAAAAI How to Evaluate a Problem Home: Tools You Can Use Kevin Kennedy, MPH CIEC Break Working With Patients: Taking an Environmental Healthy History James L. Sublett, MD FAAAAI Remediating and Maintaining a Healthy Home Paul J. Dowling, MD FAAAAI What Works, What Doesn’t and What Needs to be Done Wanda Phipatanakul, MD MS FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Discuss how diagnosis might improve with in vitro techniques to come; Discuss clinical readiness of food immunotherapy.

11:15

Course Breakout Sessions

Upon completion of this session, participants should be able to: Identify the principles of healthy homes and the relative importance of each; Identify the basic steps in taking an environmental history about a patient’s home environment; Describe the essential steps to assess home environmental hazards and conditions and mitigation.

Attendees will rotate between the following two workshops. Pre-registration and ticket required. Fee: $25. Sessions are limited to registered attendees. 10:00 am to 12:00 pm

Allied Health Session

ticket required

fee required

11:45

included in the Virtual Annual Meeting

29

FRIDAY, FEBRUARY 28 Allied Health Workshop

Allied Health Workshop

1301 Psychosocial Well-Being: Living with Food Allergies

1501 Ask the Expert: Roundtable Discussion 12:30 to 1:30 pm Marriott North Tower, Lobby Level, Presidio Rooms 1 & 2 Pre-registration and ticket required. Fee: $40. Box lunch included. Credit: 1.00 CME / 1.20 CE Moderator: John D. Milewski, Med. Admin. Joan E. Hawkins Teresa Thompson, CPC CMSCS CCC Question & Answer

9:30 to 10:45 am Marriott North Tower, Lobby Level, Marriott Hall Salon 5 Credit: 1.25 CME / 1.50 CE Panelists: Jennifer M. Darr, MSW LCSW Melissa T. Korenblat-Hanin, ACSW LCSW Upon completion of this session, participants should be able to: Describe the psychosocial dynamics of living with food allergies: challenges, emotions and accomplishments; Discuss approaches that build and enhance stability, security and sensibility using challenging case scenarios; Identify successful resources for assisting the food allergic patient and family.

11:30

Upon completion of this session, participants should be able to: Identify coding and ICD10 challenges in 2014; Discuss best practices for motivating employees; Identify how to assess your clinical practices.

Program Directors’ Business Meeting Allied Health Workshop

2:00 to 4:00 pm Marriott North Tower, Lobby Level, San Diego Ballroom Salon A All Program Directors and Co-Directors are invited to attend this business meeting.

1302 The Asthma Action Plan: Use of Simulation to Teach and Reinforce 9:30 to 10:45 am Marriott North Tower, Lobby Level, Atlanta & Chicago Credit: 1.25 CME / 1.50 CE Moderator: Maureen George, PhD RN AE-C FAAN Using Simulation to Improve Patient Education About the Asthma Action Plan Anne E. Borgmeyer, MSN RN CPNP AE-C Upon completion of this session, participants should be able to: Describe principles of patient and family-focused education; Review the use of simulation to teach patient communication strategies to providers; List the key principles of the Asthma Action Plan to improve self-management and asthma control.

Allied Health Workshop 1401 Developing and Maintaining a Successful Research Center: Secrets of a Trade 11:00 am to 12:15 pm Marriott North Tower, Lobby Level, Torrey Pines 1 & 2 Credit: 1.25 CME / 1.50 CE Moderator: Craig F. LaForce, MD FAAAAI Cheryl Koff Bernstein, RN BSN CCRC David I. Bernstein, MD FAAAAI

Course 1601 Advanced Course in Fungal Spore Identification

2:00 2:30 3:00 3:30 4:00 4:30

2:00 to 5:00 pm Marriott North Tower, Lobby Level, Marriott Hall Salon 3 Pre-registration and ticket required. Fee: $125. Credit: 3.00 CME / 3.60 CE Moderator: Estelle Levetin, PhD FAAAAI Basidiospore Identification Estelle Levetin, PhD FAAAAI Hands-On Instruction; Question & Answer Ascospore Identification W. Elliott Horner, PhD LEED AP FAAAAI Hands-On Instruction; Question & Answer Challenging Spore Types James Scott, PhD Hands-On Instruction; Question & Answer

Upon completion of this session, participants should be able to: Interpret common basidiospores; Interpret common ascospores; Describe Fusarium, Penicillium/Aspergillus and other difficult spore types.

Upon completion of this session, participants should be able to: Discuss the infrastructure necessary to establish a successful and productive research center; Discuss the challenges of maintaining a successful research center while competing in global clinical trials; Identify strategies for promoting your research center and enhancing your chances for clinical trial selection.

Allied Health Workshop 1402 The Food Allergy Spectrum: Not Just Peanuts, Eggs and Milk 11:00 am to 12:15 pm Marriott North Tower, Lobby Level, Torrey Pines 3 Credit: 1.25 CME / 1.50 CE Panelists: Pinkus Goldberg, MD FAAAAI Karen S. Rance, DNP RN CPNP AE-C Upon completion of this session, participants should be able to: Identify an evidencebased approach to managing food allergy patients with less common allergens; Discuss how to screen for possible sensitivity to food additives and preservatives; Describe a management approach for patients with multiple food allergies.

30

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

FRIDAY, FEBRUARY 28 Course

Course

1602 NIAID: Recent Advances in Biomarkers of Allergy and Asthma

1604 Difficult Cases (Part 2)

2:00

2:25 2:50 3:15 3:30 3:55 4:20 4:45

2:00 to 5:00 pm Convention Center, Upper Level, Room 11AB Credit: 2.75 CME / 3.30 CE Moderator: Marshall Plaut, MD FAAAAI Allergen Challenge as a Biomarker of Disease Severity and of the Effects of Treatment Stephen R. Durham, MA MD FRCP Transcriptomic Changes After Allergen Exposure Sunil K. Ahuja, MD Basophil Activation as a Predictor of Food Allergen Severity Alexandra F. Santos, MD MSc Break Basophil Activation as a Biomarker of Food Allergy and Asthma Wayne G. Shreffler, MD PhD FAAAAI T Regulatory Cells as Markers of Allergen Immunotherapy Andrew D. Luster, MD PhD CD27 Effector Cell Depletion During Allergen Immunotherapy Erik R. Wambre, PhD Question & Answer

Upon completion of this session, participants should be able to: Explain how mediators produced following allergen challenge predict the status of allergic diseases; Describe the relationship of successful allergen immunotherapy to effects on circulating T cell subsets and antibody responses; Appreciate the value of measuring peripheral blood basophil activation in allergic diseases and asthma.

Course

2:00

2:35

3:10 3:30

4:05

4:40

Upon completion of this session, participants should be able to discuss diagnostic and clinical management challenges encountered in allergy, asthma and immunology practice.

Course 1605 Mast Cell Activation Syndromes: From Anaphylaxis to Mastocytosis

1603 Finding a Job and Getting Started in Practice

2:00 2:05 2:40 2:55 3:05 3:40 4:15 4:50

2:00 to 5:00 pm Convention Center, Upper Level, Room 2 Credit: 3.00 CME / 3.40 CE Moderator: Tao T. Le, MD MHS FAAAAI Overview and Introductions Tao T. Le, MD MHS FAAAAI Finding a Job and Negotiating the Agreement Tao T. Le, MD MHS FAAAAI Getting Licensed and Transitioning into Practice Brian A. Smart, MD FAAAAI Break Secrets of an Efficient Allergy Practice David L. Patterson, MD MS MBA FAAAAI Practice Finances 101 Marshall P. Grodofsky, MD FAAAAI Marketing Your Practice and Referral Development Stanley M. Fineman, MD MBA FAAAAI Question & Answer

2:00 to 5:00 pm Convention Center, Mezzanine Level, Room 15AB Pre-registration and ticket required. No fee. Credit: 2.75 CME / 3.20 CE Moderators: Jason W. Caldwell, DO FAAAAI Michael H. Land, MD FAAAAI COPD vs. Asthma William W. Busse, MD FAAAAI Matthew C. Bell, MD Implant Allergy Luz S. Fonacier, MD FAAAAI Haejin Kim, MD Break New Immune Deficiencies Gulbu Uzel, MD Monica G. Lawrence, MD Mystery Rashes Lisa A. Beck, MD FAAAAI Anne Marie Singh, MD Question & Answer

2:00 2:30 3:00 3:15 3:45

4:15 4:45

2:00 to 5:00 pm Convention Center, Upper Level, Room 6A Credit: 2.75 CME / 3.30 CE Moderator: Luis Escribano, MD PhD FAAAAI Anaphylaxis to Hymenoptera Venom Patrizia Bonadonna, MD PhD Mastocytosis: Role of Tryptase and C-Kit Mutations Cem Akin, MD PhD FAAAAI Break Non-Clonal Mast Cell Activation Syndrome Mariana C. Castells, MD PhD FAAAAI When and How to Perform a Bone Marrow Study in MCAS: Practical Recommendations Luis Escribano, MD PhD FAAAAI Idiopathic Anaphylaxis Paul A. Greenberger, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Discuss the symptoms and presentation of mast cell activation syndromes (MCAS); Outline the role of tryptase and c-kit mutations in MCAS; Describe management options for MCAS.

Upon completion of this session, participants should be able to: Outline how to identify and join the right practice opportunity; Discuss the fundamentals of office management; Identify strategies for marketing a practice and building a patient base.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

31

FRIDAY, FEBRUARY 28 Course 1606 Review of Systemic Autoimmune Disease and Treatment

2:00

2:30

3:00 3:15

3:45 4:15

4:45

2:00 to 5:00 pm Convention Center, Upper Level, Ballroom 6B Credit: 3.00 CME / 3.60 CE Moderator: Arnold I. Levinson, MD FAAAAI Update on Laboratory Diagnosis of Systemic Autoimmune Disease David P. Huston, MD FAAAAI ACR Updated Recommendations for Disease-Modifying Antirheumatic Drugs and Biologic Agents in the Treatment of RA Arthur Kavanaugh, MD FAAAAI Question & Answer The Spectrum of Vasculitis: New Insights into Pathogenesis and Treatment Richard Keating, MD New Treatment Modalities for Lupus Mary Anne Dooley, MD Susceptibility to Infections in Autoimmune Disease: Is it the Disease or the Treatment? John J. Cush, MD Question & Answer

Upon completion of this session, participants should be able to: Interpret screening and follow-up reflex testing in the diagnosis of autoimmune disease; Review the latest treatment guidelines for rheumatoid arthritis; Describe the organ systems lupus can affect and the downstream sequelae of complement activation.

Upon completion of this session, participants should be able to: Discuss ethnic and geographical differences in PID prevalence and clinical presentation around the world; Discuss international vaccine programs and challenges posed for the PID community; Review clinical scenarios of PID management in different settings around the world.

Course 1608 NIEHS: Exposure to Indoor Allergens and Endotoxin in Relation to Allergic Disease: Results from NHANES 2005-2006 2:00 to 5:00 pm Convention Center, Upper Level, Ballroom 6DE Credit: 2.75 CME / 3.20 CE Moderators: Paivi M. Salo, PhD Darryl C. Zeldin, MD Overview of the NHANES 2005-2006 Allergy Component Darryl C. Zeldin, MD Multiplexed Allergen Measurements: New Standards and Performance Parameters Eva-Maria King, PhD NHANES 2005-2006: Getting to Grips with the Big Data Agustin Calatroni, MA MS Break IgE Sensitization and Current Allergen Exposure: Implications for Environmental Intervention Herman Mitchell, PhD Environmental Exposures and Allergy Symptoms Paivi M. Salo, PhD Which Combinations of IgE Clusters and Exposures Have the Greatest Impact on Asthma? Peter J. Gergen, MD MPH Endotoxin Exposure Assessment and Respiratory Disease Peter S. Thorne, PhD Question & Answer

2:00 2:20

2:40 3:00 3:20

3:40 4:00

Course 1607 Primary Immune Deficiency: A Global Perspective

2:00

2:25

2:50

3:15 3:25

3:35

4:00 4:25

4:50

32

2:00 to 5:00 pm Convention Center, Upper Level, Ballroom 6CF Credit: 3.00 CME / 3.40 CE Moderator: Motohiro Ebisawa, MD PhD FAAAAI An Overview of Primary Immunodeficiency Diseases Around the World Fred Modell Vaccine-Associated Paralytic Polio and Other Live Attenuated Vaccine-Associated Disease in Immunodeficient Infants Antonio Condino-Neto, MD PhD Clinical Cases: Diagnosis and Management of Primary Immunodeficency Around the World Elham M. Hossny, MD PhD FAAAAI Question & Answer Break Moderators: Elham M. Hossny, MD PhD FAAAAI Mona I. Kidon, MD FAAAAI Defects of Human Immunity and Mycobacterium Diseases Around the World Stephanie Boisson-Dupuis, MD Molecular Mechanisms of Hyper IgE Syndromes Speaker to be announced. Malnutrition, Vitamin Deficiencies, the Immune System and Infections: Time to Revisit Our Knowledge Raz Somech, MD PhD Question & Answer

4:20 4:40

Upon completion of this session, participants should be able to: Interpret the role that allergen/endotoxin exposures and allergic sensitization play in allergic diseases; Apply new, standardized methods in indoor allergen assessment; Review strategic objectives of NHANES and the allergy component.

Course 1609 Allergen Immunotherapy: The Nuts and the Bolts (Part 2)

2:00 2:30

2:00 to 3:00 pm Convention Center, Upper Level, Room 30CDE Pre-registration and ticket required. No fee. Credit: 1.00 CME / 1.20 CE Moderator: Michael R. Nelson, MD PhD FAAAAI SCIT and SLIT: Optimal Dosing, Regimen and Duration Harold S. Nelson, MD FAAAAI Allergen Immunotherapy: Practical Considerations, CostEffectiveness, Adherence and Quality of Life Cheryl S. Hankin, PhD

Upon completion of this session, participants should be able to: Describe how immunotherapy can easily be dosed and the knowledge gaps we still have in this field; Discuss when doses might need to be adjusted for SCIT and for SLIT.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

FRIDAY, FEBRUARY 28 Course

Course Breakout Sessions Attendees may attend one of the following sessions. Pre-registration and ticket required. Fee: $25. Sessions are limited to registered attendees. 3:00 to 5:00 pm

1609A/D Hands-On Workshop: Media Fill Test and Extract Preparation Management

1611 Career Building for the Junior Investigator

2:00

Convention Center, Upper Level, Room 32AB Credit: 1.00 CME / 1.20 CE Donald W. Aaronson, MD FAAAAI Michael S. Blaiss, MD FAAAAI Susan E. Kosisky, BS MHA Cecilia Mikita, MD MPH FAAAAI Michael R. Nelson, MD PhD FAAAAI Upon completion of this session, participants should be able to demonstrate the ability to make a sterile immunotherapy vial.

1609B/C Allergen Immunotherapy Prescription Writing: Cross-Reactivity, Proteolytic Enzymes, Diluents and Other Factors

3:05 3:20 3:40

Convention Center, Upper Level, Room 33AB Credit: 1.00 CME / 1.20 CE Rohit Katial, MD FAAAAI Bryan L. Martin, DO FAAAAI Michael S. Tankersley, MD FAAAAI Upon completion of this session, participants should be able to demonstrate the proper method for writing immunotherapy prescriptions for optimal efficacy and safety.

Course

4:45

1610 Personalized Medicine Approaches in Asthma and Allergy

2:00 2:30 3:10 3:30

4:05

4:40

2:00 to 5:00 pm Convention Center, Upper Level, Room 8 Credit: 2.75 CME / 3.20 CE Moderator: Antonella Cianferoni, MD PhD CyTOF Flow: The New Frontier Jonathan M. Irish, PhD Lessons Learned from Genetic Diseases of Allergy Joshua D. Milner, MD Break Using Biomarkers and Genomics to Personalize Therapeutics for Allergy and Asthma Stanley J. Szefler, MD FAAAAI Establishing a Personalized Medicine Program: The Harvard Experience Scott T. Weiss, MD MS Question & Answer

Upon completion of this session, participants should be able to: Discuss the availability for genetic variation in disease risk, progression and therapy; Describe readily available predictive tests (genetic and non-genetic); Describe the use and cost effectiveness of a personalized medicine approach in clinical practice.

Allied Health Session

ticket required

fee required

2:00 to 5:00 pm Convention Center, Upper Level, Room 1AB Credit: 2.75 CME / 3.20 CE Moderator: Laura B. Fanning, MD Panel Discussion: Career Advice from Established Investigators: Strategies to Establish Scientific/Clinical Expertise Effective Time Management Effective Lab Management Andrea J. Apter, MD MA MSc FAAAAI Kathleen C. Barnes, PhD FAAAAI Joshua A. Boyce, MD FAAAAI James E. Gern, MD FAAAAI Mitchell H. Grayson, MD FAAAAI Question & Answer Break Panel Discussion: Career Advice from Junior Investigators: Time Management Strategies Strategies for Work and Family Life Balance Data Management Grant Writing Nora A. Barrett, MD FAAAAI Patrick J. Brennan, MD PhD Taylor A. Doherty, MD FAAAAI Tanya M. Laidlaw, MD FAAAAI Brian P. Vickery, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Discuss how to develop a specific clinical and scientific expertise; Discuss how to manage their time effectively and how to choose roles and projects wisely; Describe benchmarks of success.

Course 1612 Hands-On Rhinolaryngoscopy

2:00 3:15 3:30

2:00 to 5:00 pm Convention Center, Upper Level, Room 30AB Pre-registration and ticket required. Fee: $50. Credit: 2.75 CME / 3.30 CE Moderator: Jerald W. Koepke, MD FAAAAI Intro to Rhinolaryngoscopy Jerald W. Koepke, MD FAAAAI Break Hands-On Instruction Allen D. Adinoff, MD FAAAAI Kevin R. Murphy, MD Grant C. Olson, MD Donald W. Pulver, MD FAAAAI C. Ross Westley, MD FAAAAI

Upon completion of this session, participants should be able to: Describe the surgical anatomy of the upper airway, including the nasal cavity, pharynx and larynx; Identify examples of normal and abnormal anatomy, as well as disease presentations and post-operative changes found with endoscopic examination of the upper airway; Identify indications for and the use of the fiberoptic rhinoscope in the allergist’s office.

included in the Virtual Annual Meeting

33

FRIDAY, FEBRUARY 28 Course

Problem-Based Learning Workshop

1613 Interpretation of Pulmonary Function Tests (PFTs)

2:00 2:05 2:30 2:40 3:10 3:25 3:30

2:00 to 5:00 pm Convention Center, Upper Level, Room 33C Pre-registration and ticket required. No fee. Credit: 3.00 CME / 3.50 CE Moderator: Mark F. Sands, MD FAAAAI Introductory Remarks Pathophysiology and the PFT Mark F. Sands, MD FAAAAI Performing PFT: Video Demonstration John M. Weiler, MD FAAAAI Interpretation of the PFT: Putting it All Together Donald P. Tashkin, MD Question & Answer Break Hands-On Workshop Donald W. Cockcroft, MD FAAAAI Meredith C. McCormack, MD Riccardo Polosa, MD PhD FAAAAI Mark F. Sands, MD FAAAAI Donald P. Tashkin, MD John M. Weiler, MD FAAAAI

5:00 to 6:15 pm Convention Center, Upper Level, Room 3 Pre-registration and ticket required. Fee: $50. Credit: 1.25 CME / 1.50 CE PBL Facilitator: Richard L. Wasserman, MD PhD FAAAAI Content Lecturer: Dinakantha Kumararatne, MD PhD Upon completion of this session, participants should be able to: Describe the currently known causes of defective innate immunity; Describe the clinical presentation of defects in innate immunity; Discuss the selection and interpretation of laboratory tests to diagnose defects in innate immunity.

Q & A Workshop 1802 Difficult to Manage Asthma: The Very Young, the Very Old and the Obese

5:00

Upon completion of this session, participants should be able to: Describe the components of pulmonary function testing; Recognize simple and complex obstructive and restrictive pulmonary abnormalities; Interpret PFTs from asthma and COPD to fixed and variable obstructive abnormalities, as well as interstitial and other restrictive diseases.

Clinical Research Symposium

2:30

3:00

5:15

5:30

1621 Tools of the Trade

2:00

1801 Diagnosis of Patients with Defects in Innate Immunity Including TLR Pathway Defects

2:00 to 3:15 pm Marriott North Tower, Lobby Level, Torrey Pines 3 Credit: 1.25 CME / 1.50 CE Moderator: Jaime E. Ross, RN What You Need to Know to Prepare for an FDA Audit Kim E. Mudd, RN MSN CCRP Developing Your Monitoring Plan: Improving the Quality of the Research Janet S. Kamilaris, RN Question & Answer

Upon completion of this session, participants should be able to: Describe the components of a monitoring plan; List the methods to keep a clinical trial site ready for an audit; Identify the proper use of a note to file and describe its limitations.

5:45

Upon completion of this session, participants should be able to: Identify emerging diagnostic modalities for asthma that may be useful in children under age 5 years; Develop strategies to distinguish asthma from other potential comorbid conditions in elderly asthmatics and implement age-appropriate management strategies in older asthmatics; Summarize recent data regarding the obese asthmatic phenotype and critically assess current management strategies in this subgroup of asthmatics.

Q & A Workshop 1803 What are Damp Buildings and How Do They Cause Problems?

Allied Health Plenary 1701 Cybersecurity: Technology in Practice 4:00 to 5:15 pm Marriott North Tower, Lobby Level, Marriott Hall Salon 5 Credit: 1.25 CME / 1.50 CE Moderator: Sally A. Noone, RN MSN CCRC Larry Thompson Upon completion of this session, participants should be able to: Identify actions to protect hardware and software; Describe how to implement security measures to protect a practice; Identify how to set up emergency plans in case of a breach.

34

5:00 to 6:15 pm Convention Center, Mezzanine Level, Room 14AB Credit: 1.25 CME / 1.50 CE Moderator: Timothy J. Craig, DO FAAAAI What to Do When Your Patient Can’t Tell You What’s Wrong: Challenges in the Diagnosis and Management of Asthma in Children Under Age Five Joseph D. Spahn, MD Pitfalls in the Diagnosis and Management of Asthma in Older Adults: An Evidence-Based Update Tolly Epstein, MD MS New Insights into the Obese Asthma Phenotype: Diagnostic and Therapeutic Challenges in Obese Asthmatics Juan C. Celedon, MD DrPH FAAAAI Question & Answer

5:00 5:15 5:30 5:45

5:00 to 6:15 pm Convention Center, Upper Level, Room 5AB Credit: 1.25 CME / 1.50 CE Moderator: Jay M.Portnoy, MD FAAAAI Innate Immunity Factors from Fungi Anthony A. Horner, MD FAAAAI Damp Buildings, Respiratory Disease and Asthma Kari E. Reijula, MD PhD FAAAAI Allergens from Damp Housing Eva-Maria King, PhD Question & Answer

Upon completion of this session, participants should be able to: Review the multiple expert panels/reports and Position Statements concluding that there is adequate evidence for respiratory health impacts, including new onset asthma, due to damp buildings; Describe the challenges of quantifying dampness and establishing acceptable moisture levels; Recognize the several plausible mechanisms that underlie the adverse respiratory impacts of the damp building effect.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

FRIDAY, FEBRUARY 28 Q & A Workshop

Seminars

1804 The Science Behind Complementary and Alternative Medicine

5:00 5:15 5:30

5:45

5:00 to 6:15 pm Convention Center, Upper Level, Room 7AB Credit: 1.25 CME / 1.50 CE Moderator: William S. Silvers, MD FAAAAI Role of Vitamin D in Allergic Inflammation Katrina Jane Allen, MD PhD FAAAAI Immunomodulation by Chinese Herbal Medicine in Food Allergy Julie Wang, MD FAAAAI Probiotics, Prebiotics and Synbiotics For Prevention and Treatment of Allergic Disease Mimi L.K. Tang, MD PhD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Explain the role of vitamin D in allergic inflammation; Discuss the immunomodulatory effects of Chinese herbal medicine for food allergy; Describe the role of prebiotics and probiotics in the prevention and treatment of allergy.

Q & A Workshop 1805 Difficult Situations in Practice Management

5:00

5:15

5:30

5:45

5:00 to 6:15 pm Convention Center, Mezzanine Level, Room 16AB Credit: 1.25 CME / 1.50 CE Moderator: Tao T. Le, MD MHS FAAAAI Employment Agreements and Partnerships Adhuna C. Mathuria, MD Robert J. Holzhauer, MD MBA FAAAAI Hiring and Firing Vinay Mehta, MD FAAAAI Weily Soong, MD FAAAAI Marketing and Referral Development Sakina S. Bajowala, MD FAAAAI Stanley M. Fineman, MD MBA FAAAAI Question & Answer

5:15 to 6:15 pm Pre-registration and ticket required. Fee: $40. Refreshments included. Sessions and refreshments are limited to 30 people. Credit: 1.00 CME / 1.20 CE

1901 Allergen Immunotherapy or Omalizumab in Asthma: When to Use Which? Thomas B. Casale, MD FAAAAI Jonathan Corren, MD Marriott South Tower, Level 3, Balboa Upon completion of this session, participants should be able to: Review efficacy of AIT in asthma and safety of AIT in moderate to severe asthma; Review studies of omalizumab alone and in combination with AIT in asthma; Make recommendations on individual use of these drugs and in combination for asthma.

1902 When is an Elevated IgE Level a Sign of Immunodeficiency? Alexandra F. Freeman, MD Hans D. Ochs, MD Marriott South Tower, Level 3, Mission Hills Upon completion of this session, participants should be able to: Review the differential diagnosis of an elevated IgE level; Discuss the work up necessary in patients with elevated IgE levels; Review the Hyper IgE syndromes.

1903 How to Assess and Manage a Child with Multiple Positive Environmental and Food Allergy Tests Sami L. Bahna, MD DrPH FAAAAI Anna H. Nowak-Wegrzyn, MD FAAAAI Marriott South Tower, Level 3, Cardiff Upon completion of this session, participants should be able to: Explain the prevalence and difference between classic food allergies and pollen-food allergy syndrome; Describe the utility of skin prick, fresh food skin prick, serum specific IgE testing, component resolved diagnostics and oral food challenge in assessment of complex patients with multiple food and environmental sensitizations; Discuss the management of complex patients with multiple food and environmental sensitivities and/or allergies.

1904 So the Patient Has Eosinophilia: What Next? Amy D. Klion, MD Catherine R. Weiler, MD PhD FAAAAI Marriott South Tower, Level 1, Point Loma

Upon completion of this session, participants should be able to: Identify and address difficult situations regarding employment and partnership contracts; Evaluate difficult situations in hiring and firing; Investigate difficult situations in marketing.

Upon completion of this session, participants should be able to: Review diagnosis of various hypereosinophilic syndromes; Describe identification of secondary eosinophilia; Discuss therapeutic approaches to hypereosinophilic syndrome.

International Reception

1905 Mechanisms and Biomarkers Related to Sublingual and Subcutaneous Immunotherapy

5:00 to 6:00 pm Convention Center, Upper Level, Ballroom 6CF All international members and delegates are invited to attend this reception.

Allied Health Wine and Cheese Reception 5:15 to 6:15 pm Marriott South Tower, Level 4, La Costa All allied health members and their guests are invited to attend this reception for an evening of networking with other allied health professionals.

Allied Health Session

ticket required

fee required

Giovanni Passalacqua, MD Mohamed H. Shamji, BSc MSc PhD Marriott South Tower, Level 1, Solana Upon completion of this session, participants should be able to: Discuss humoral mechanisms of SCIT and SLIT; Discuss cellular mechanisms of SCIT and SLIT; Discuss novel biomarkers of successful SCIT and SLIT.

Annual Meeting Seminars and Workshops Programmed by the AAAAI. Annual Meeting Seminars and Workshops funded through an educational grant from Merck.

included in the Virtual Annual Meeting

35

FRIDAY, FEBRUARY 28 2014 Federation of RSLAAIS Assembly Forum, Business Meeting and Reception

4:45 5:10 5:20

6:10

6:15

6:20 6:30

36

4:45 to 6:30 pm San Diego Convention Center, Upper Level, Room 31AB Wine and Cheese Welcome Reception RSLAAIS Assembly Business Meeting Moderator: Sharon B. Markovics, MD FAAAAI, RSLAAIS Chair ACOs: Will they really be “accountable?” Co-Moderators: Marshall P. Grodofsky, MD FAAAAI, RSL Governor Jody T. Inglefield, MD FAAAAI, RSL Governor Speakers: Jonathan L. Bayuk, DO FAAAAI Hampden County Physician Associates Springfield, MA Warner W. Carr, MD FAAAAI Allergy and Asthma Associates of Southern California Joint Council of Allergy, Asthma and Immunology (JCAAI) Update Richard W. Honsinger, MD MACP FAAAAI President, JCAAI American Board of Allergy and Immunology (ABAI) Update Stephen I. Wasserman, MD FAAAAI President, ABAI What’s Next With RSLs Adjourn

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

SATURDAY, MARCH 1 Seminars

or scheduled splenectomy.

7:00 to 8:00 am Pre-registration and ticket required. Fee: $40. Continental breakfast included. Sessions and meals are limited to 30 people. Credit: 1.00 CME / 1.20 CE

2006 An Update on the Diagnosis and Treatment of Chronic Granulomatous Disease (CGD) Alexandra F. Freeman, MD Peter J. Mustillo, MD FAAAAI Marriott South Tower, Level 3, Mission Hills

2001 Microbiota and Asthma Yvonne Huang, MD Marriott South Tower, Level 3, Marina Ballroom Salon D Upon completion of this session, participants should be able to: Review the importance of the microbiota in asthma and allergic disorders; Discuss the dangers of inappropriate antibiotic use on the microbiota; Describe fostering a healthy microbiota.

2002 Provocative Testing for Exercise-Induced Asthma: Methacholine vs. Mannitol vs. Exercise Donald W. Cockcroft, MD FAAAAI John M. Weiler, MD FAAAAI Marriott South Tower, Level 3, Marina Ballroom Salon E Upon completion of this session, participants should be able to: Discuss indications/ contraindications for bronchoprovocation challenges in patients with EIB; Describe the strengths and weaknesses of each in the evaluation of hyper-reactivity; Identify methacholine and mannitol challenge as potential tests for monitoring asthma treatment.

2003 Monitoring and Managing Non-Infectious Complications of Common Variable Immune Deficiency Charlotte Cunningham-Rundles, MD PhD FAAAAI Rima A. Rachid, MD FAAAAI Marriott South Tower, Level 3, Marina Ballroom Salon F Upon completion of this session, participants should be able to: Review the non-infectious complications of CVID; Discuss how to monitor and treat these complications.

Upon completion of this session, participants should be able to: Describe current diagnostic tests for CGD; Review treatment options for patients with CGD including consideration for bone marrow transplant.

2007 How to Be a Mold Sleuth Anupma B. Dixit, PhD H. James Wedner, MD FAAAAI Marriott South Tower, Level 3, Cardiff Upon completion of this session, participants should be able to: Discern the quality of building inspection reports regarding water damage and mold colonization in housing; Describe mold sampling data to assess the significance of occupant exposure to molds indoors.

2008 Pathogenic Bacteria and Viral Illness: Are They Associated? What the Microbiome Tells Us James E. Gern, MD FAAAAI Kirsten Kloepfer, MD Marriott South Tower, Level 3, Del Mar Upon completion of this session, participants should be able to: Describe the association between pathogenic bacteria and asthma exacerbations; Discuss potential mechanisms for viral infections to promote infections with pathogenic airway bacteria; Discuss potential treatment implications related to bacterial infections, wheezing illnesses and exacerbations of asthma.

2009 Aspirin and Antibiotic Desensitization Anahita F. Dioun, MD FAAAAI Catherine R. Weiler, MD PhD FAAAAI Marriott South Tower, Level 3, Miramar

2004 There’s an App for That: Using Smart Phones, Tablets and Web Tools for Clinical Practice Tao T. Le, MD MHS FAAAAI Melinda M. Rathkopf, MD FAAAAI Marriott South Tower, Level 3, Marina Ballroom Salon G Upon completion of this session, participants should be able to: Describe the various device options and platforms available to the clinician; Discuss the various apps available for the various devices and how to maximize their use; Identify web tools useful in the allergy practice.

Upon completion of this session, participants should be able to: Describe what is needed to perform a desensitization in the office; Discuss the desensitization of aspirin allergic patients; Describe the desensitization of antibiotic allergic patients.

2010 Fifty Shades of Eosinophilic Esophagitis: Identifying the Phenotypes Juan Pablo Abonia, MD Mirna Chehade, MD MPH Marriott South Tower, Level 1, Point Loma

2005 Immunizing the Immunodeficient Patient Francisco A. Bonilla, MD PhD FAAAAI M. Louise Markert, MD PhD FAAAAI Marriott South Tower, Level 3, Balboa Upon completion of this session, participants should be able to: Identify laboratory findings that may predict when live viral vaccinations may be administered to patients with cellular immunodeficiency; Describe factors involved in timing of live viral vaccinations after immunosuppressive medications; Discuss vaccinations and timing for patients with asplenia

Upon completion of this session, participants should be able to: Demonstrate the ability to identify EoE co-morbidities; Recognize when to suspect EoE given the medical history, whenever esophageal eosinophilia is found; Discuss how to investigate for other potentially associated diseases with EoE that require medical attention.

2011 Getting Ready for ICD-10: Cracking the Code Priya J. Bansal, MD FAAAAI Marshall P. Grodofsky, MD FAAAAI Marriott South Tower, Level 1, Solana Upon completion of this session, participants should be able to: Describe the differences between ICD-10 and ICD-9-CM; Discuss the impact of ICD-10 on billing and coding; Identify strategies for implementing ICD-10 in clinical practice.

2012 Component-Resolved Diagnosis for Inhalant Allergies

Annual Meeting Seminars

Reto Crameri, PhD Peter Schmid-Grendelmeier, MD PhD Marriott South Tower, Level 1, Santa Rosa

Programmed by the AAAAI. Annual Meeting Seminars funded through an educational grant from Merck.

Upon completion of this session, participants should be able to: Describe cross-reactivity between various inhalant allergens and food allergens; Define predictive value of CRD for disease outcome; Identify better selection criteria for allergen-specific immunotherapy.

38

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

SATURDAY, MARCH 1 Allied Health Workshop

2013 Cockroach Immunotherapy Luisa Karla P. Arruda, MD PhD FAAAAI William W. Busse, MD FAAAAI Marriott South Tower, Level 4, La Costa

2023 Management of Atopic Dermatitis

Upon completion of this session, participants should be able to: Discuss epidemiologic studies on cockroach allergy, including outcomes of abatement procedures; Describe characteristics of cockroach allergens and composition of cockroach extracts currently available; Discuss ongoing and published studies on cockroach immunotherapy and new perspectives for treatment of cockroach allergy.

2014 Alternative Pathways of Antigen-Mediated Anaphylaxis Mary Beth Hogan, MD FAAAAI Wei Zhao, MD PhD FAAAAI Marriott South Tower, Level 4, Catalina

Upon completion of this session, participants should be able to: Identify and differentiate atopic dermatitis from other skin conditions; Demonstrate appropriate skin care including wet to dry dressings; Discuss how to teach patients and families about proper skin care.

Upon completion of this session, participants should be able to: Review the traditional pathway of anaphylaxis; Discuss the role of basophils and neutrophils in the pathogenesis of anaphylaxis; Distinguish IgE (mast cell) mediated anaphylaxis from IgG/Platelet Activating Factor as an alternative mechanism of anaphylaxis.

2015 Interpreting Anti-IL5 Trial Data: Implications for Asthma, EoE and HES Pathophysiology Steven J. Ackerman, PhD Sameer K. Mathur, MD PhD FAAAAI Marriott South Tower, Level 4, Coronado Upon completion of this session, participants should be able to: Discuss the different types of anti-IL-5 therapy in use in clinical trials; Review the outcomes of anti-IL-5 therapy for asthma, eosinophilic esophagitis and hypereosinophilic syndrome.

Allied Health Workshop 2021 The Ins and Outs of Management of Chronic Eosinophilic Esophagitis

6:45 7:00 7:15 7:30

6:45 to 8:00 am Marriott North Tower, Lobby Level, Torrey Pines 1 & 2 Pre-registration and ticket required. No fee. Credit: 1.25 CME / 1.50 CE Moderator: William R. Blouin, ARNP Instructors: Carla M. Duff, CPNP MSN Sally A. Noone, RN MSN CCRC Karol G. Timmons, RN MS CPNP

6:45 to 8:00 am Marriott North Tower, Lobby Level, Marriott Hall Salon 1 Credit: 1.25 CME / 1.50 CE Moderator: Debra A. Sedlak, MSN CPNP Are You Missing the EoE Patient? It Starts with the History Katie J. Atkinson, RN CFNP Diagnosis and Treatment Options: Diet or Steroids? Seema Sharma Aceves, MD PhD FAAAAI Meeting the Patient’s Needs: Nutrition and Quality of Life Marion E. Groetch, MS RD Question & Answer

Upon completion of this session, participants should be able to: List the common symptoms of esosinophilic esophagitis (EoE) and the history that may trigger suspicion of EoE; Identify appropriate treatment options; Define how to guide patients on elimination diets to meet nutritional needs and maintain quality of life.

Allied Health Workshop 2022 What Allied Health Professionals Need to Know About Drug Sensitivity 6:45 to 8:00 am Marriott North Tower, Lobby Level, Marriott Hall Salon 2 Credit: 1.25 CME / 1.50 CE Moderator: Kim E. Mudd, RN MSN CCRP Miguel A. Park, MD

Allied Health Workshop 2024 Bring Your Own Pediatric Food Challenge Experience 6:45 to 8:00 am Marriott North Tower, Lobby Level, Torrey Pines 3 Credit: 1.25 CME / 1.50 CE Moderator: Suzanne K. Carlisle, RN BSN CCRP Elisabeth S. Stieb, RN BSN AE-C Anne M. Hiegel, RN CRC Upon completion of this session, participants should be able to: Discuss solutions to common problems encountered when conducting oral food challenges; Develop access to a network of health care providers conducting food challenges and interact with them as needed throughout the year.

Allied Health Workshop 2025 Exploring the Spectrum of Gluten-Related Disorders 6:45 to 8:00 am Marriott North Tower, Lobby Level, Atlanta Credit: 1.25 CME / 1.50 CE Isabel J. Skypala, PhD Berber Vlieg-Boerstra, PhD RD Upon completion of this session, participants should be able to: Discuss the various gluten-related disorders; Discuss strategies based on the individual patient’s glutenrelated disorder.

Allied Health Workshop 2026 Pharmacology of Tobacco Cessation Medications 6:45 to 8:00 am Marriott North Tower, Lobby Level, Chicago Credit: 1.25 CME / 1.50 CE Beth A. Allison, NP Upon completion of this session, participants should be able to: Describe nicotine dependence and nicotine withdrawal; Discuss evidence-based use of smoking cessation medications.

Upon completion of this session, participants should be able to: Define the key components of the drug allergy history; Discuss diagnostic tests and work-up for drug allergies; Review the treatment options for drug allergies.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

39

SATURDAY, MARCH 1 Plenary

Hands-On Workshop

2101 Immunotherapy: Mechanism, Outcomes and Markers

2251 Adolecent Allergy/Asthma Simulation

8:15

8:45 9:15

8:15 to 9:45 am Convention Center, Ground Level, Exhibit Hall A Credit: 1.50 CME / 1.80 CE Moderator: Linda Cox, MD FAAAAI Tolerance to Allergens: How it Develops and How it Can be Induced Cezmi A. Akdis, MD FAAAAI Biomarker Predictors of Effective Immunotherapy Stephen R. Durham, MA MD FRCP SIT Outcomes: Examining the Data for Efficacy, Safety, Adherence and Costs Linda Cox, MD FAAAAI

10:00 am to 2:15 pm Convention Center, Ground Level, Exhibit Hall B Pre-registration and ticket required. No fee. Credit: 0.50 CME / 0.60 CE Participate in a live simulation of treating an adolescent patient experiencing allergies and asthma, working with faculty and standardized patients from the University of San Diego. Upon completion of this session, participants should be able to demonstrate appropriate clinical skills to be used when treating an adolescent patient at risk of, or experiencing, allergies or asthma.

Hands-On Workshop 2252 Adult Anaphylaxis Simulation 10:00 am to 2:15 pm Convention Center, Ground Level, Exhibit Hall B Pre-registration and ticket required. No fee. Credit: 0.50 CME / 0.60 CE Participate in a live simulation of treating an adolescent patient experiencing allergies and asthma, working with faculty and standardized patients from the University of San Diego.

Upon completion of this session, participants should be able to: Discuss the benefits of specific immunotherapy; Describe factors affecting safety of specific allergy immunotherapy; Discuss the use of biomarkers to predict the response to immunotherapy to pollens.

Posters 7:00 am to 6:00 pm Convention Center, Ground Level, Exhibit Hall B Posters on display from 7:00 am to 6:00 pm. Authors present from 9:45 to 10:45 am. Credit: No CME / No CE Refer to pages 83 – 158 for abstracts and authors.

2201 Asthma Therapeutics: Advances in Biologics and Drugs 2202 Asthma Epidemiology 2203 Primary Antibody Deficiencies 2204 Asthma Epidemiology, Risk Factors, and Public Health I 2205 Aerobiology I 2206 Insect Hypersensitivity/Anaphylaxis 2207 HAE and Angioedema 2208 Population Health in Asthma 2209 Healthcare Delivery in Primary Immunodeficiency 2210 Diagnostics 2211 Oral Immunotherapy 2212 Mechanisms of Cytokines and Chemokines 2213 Role of Granulocytes and Mast Cells in Mechanisms of Allergic Disease 2214 Allied Health Poster Session

40

Upon completion of this session, participants should be able to demonstrate appropriate clinical skills to be used when treating an adult patient at risk of, or experiencing anaphylaxis.

Symposium 2301 Oral Immunotherapy (OIT)

10:45 11:05 11:25

11:45

10:45 am to 12:00 pm Convention Center, Ground Level, Exhibit Hall A Credit: 1.25 CME / 1.50 CE Moderator: J. Andrew Bird, MD FAAAAI Current Protocols for Oral Immunotherapy Kari C. Nadeau, MD PhD FAAAAI Oral Immunotherapy: Native or Modified Allergen? Hugh A. Sampson, MD FAAAAI When Should We Stop Oral Immunotherapy? When Should it be Restarted? Giovanni B. Pajno, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Identify patients with IgE-mediated food allergy who represent a target for OIT; Examine different protocols for different foods; Outline the risk-benefit ratio of OIT.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

SATURDAY, MARCH 1 Symposium

Symposium

2302 World Allergy Forum: Anaphylaxis: From Mechanisms to Novel Therapeutics

2304 NHLBI’s Clinical Asthma Research Network’s (AsthmaNet) Approach to Key Asthma Questions

10:45

11:05 11:25 11:45

10:45 am to 12:00 pm Convention Center, Upper Level, Ballroom 6B Credit: 1.25 CME / 1.50 CE Moderators: Linda Cox, MD FAAAAI Lanny J. Rosenwasser, MD FAAAAI Diagnosis and Prevention of IgE and Non-IgE-Mediated Anaphylaxis Fred D. Finkelman, MD Causes of Anaphylaxis Motohiro Ebisawa, MD PhD FAAAAI Treatment of Anaphylaxis: Recent Advances F. Estelle R. Simons, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: List the etiology and mechanisms of anaphylaxis; Recognize the most common triggers in anaphylaxis; Discuss the management of anaphylaxis including an action plan for prevention.

10:45

11:05

11:25 11:45

10:45 am to 12:00 pm Convention Center, Upper Level, Ballroom 6A Credit: 1.25 CME / 1.50 CE Moderators: William W. Busse, MD FAAAAI James P. Kiley, PhD What Roles Do Novel and Not-So Novel Medications Have in Treating Preschool Wheezers? Leonard B. Bacharier, MD FAAAAI Is LABA or Increased Dose of ICS the Best Step-Up Therapy for African Americans: Do Children Respond Differently Than Adults? Michael E. Wechsler, MD Does Vitamin D Have a Role in Clinical Asthma? Mario Castro, MD MPH Question & Answer

Upon completion of this session, participants should be able to: Outline therapeutic options to optimize asthma treatment early in life; Describe the unique therapeutic approaches that produce improved outcomes in African-American patients; Discuss the use of Vitamin D as a therapeutic agent for treating asthma.

Symposium

Symposium

2303 The Expanding Universe of Primary Immunodeficiency

2305 The Indoor Air Exposome in Work, School and Home: Taking in the Whole Picture

10:45 11:05 11:25 11:45

10:45 am to 12:00 pm Convention Center, Upper Level, Ballroom 6CF Credit: 1.25 CME / 1.50 CE Moderator: M. Teresa De La Morena, MD The Ever-Expanding Spectrum of PID Troy R. Torgerson, MD PhD Diagnosing PID in 2014 Kathleen E. Sullivan, MD PhD FAAAAI Supporting and Reconstituting Immune Function M. Louise Markert, MD PhD FAAAAI Question & Answer

10:45 11:05

11:25

Upon completion of this session, participants should be able to: Describe how discovery of new immunodeficiencies leads to new insights into immune system biology; Develop a stepwise approach to diagnosing the broad range of immunodeficiencies; Discuss the latest developments in the therapy of immunodeficiency.

Allied Health Session

ticket required

fee required

11:45

10:45 am to 12:00 pm Convention Center, Mezzanine Level, Room 14AB Credit: 1.25 CME / 1.50 CE Moderator: Jill A. Poole, MD FAAAAI Exposure Assessments and Risk of Disease in Multiple Settings Wanda Phipatanakul, MD MS FAAAAI Pesticides, Chemicals and Other Exposures Matter in Allergic Disorders Rachel L. Miller, MD FAAAAI Evaluation and Management of Patients Presenting with Suspected Building-Related Illness Karin A. Pacheco, MD MSPH FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Describe the most common indoor air quality issues that cause negative health effects; Identify the emerging role of pesticides, chemicals and other exposures in modulating allergic sensitization, epigenetic markers and health outcomes; Outline best practices for clinical assessment of susceptible workers exposed to poor office indoor air quality and remediation strategies to create a healthy office indoor air quality environment.

included in the Virtual Annual Meeting

41

SATURDAY, MARCH 1 Symposium

Symposium

2306 Mechanisms of Virus-Induced Asthma

2308 The Relevance of Microbes and Their Diversity in Chronic Rhinosinusitis and Asthma

10:45

11:05

11:25 11:45

10:45 am to 12:00 pm Convention Center, Mezzanine Level, Room 15AB Credit: 1.25 CME / 1.50 CE Moderator: Mitchell H. Grayson, MD FAAAAI Local Interactions Betweens Dendritic Cells and T Cells in the Antiviral Immune Response Kevin Legge, PhD The Neutrophilic Antiviral Response: Is There More Than Meets the Eye? Dorothy S. Cheung, MD FAAAAI The Chronic NKT-Macrophage Axis in Asthma Michael J. Holtzman, MD FAAAAI Question & Answer

10:45 11:05 11:25

11:45

10:45 am to 12:00 pm Convention Center, Upper Level, Room 30ABCDE Credit: 1.25 CME / 1.50 CE Moderator: Martin Wagenmann, MD FAAAAI Asthma and the Relevance of the Microbiome Trevor ThomasHansel, MD PhD Biofilms in Chronic Rhinosinusitis James Palmer, MD Don’t Underestimate Viruses as Relevant Factors in the Development of Chronic Airway Disease Daniel J. Jackson, MD Question & Answer

Upon completion of this session, participants should be able to: Discuss how innate lymphoid cells contribute to airway inflammation in response to viral infections; Discuss new understanding of the neutrophilic response during viral infections; Describe how NKT cells and macrophages drive a chronic post-viral asthma phenotype.

Upon completion of this session, participants should be able to: Discuss the relevance of microbial diversity in the development of asthma; Define alterations in resident microbiota relevant for chronic rhinosinusitis presentation and treatment; Recognize the importance of viral infections in the development of chronic lower airway disease.

Symposium

Allied Health Workshop

2307 Innovative Methods for Reducing Asthma Disparities

2311 Anaphylaxis Recognition and Management: What People Need to Know

10:45

11:05

11:25

11:45

10:45 am to 12:00 pm Convention Center, Mezzanine Level, Room 16AB Credit: 1.25 CME / 1.50 CE Moderator: Mary E. Bollinger, DO Reaching Kids Where They Are: School-Based Asthma Interventions Minal R. Patel, PhD MPH Telemedicine: How Can it be Utilized to Decrease Barriers to Asthma Healthcare? Tamara T. Perry, MD Can Web-Based and Mobile Applications Improve Asthma Outcomes? Giselle Mosnaim, MD MS FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Describe the impact of web and mobile-based interventions for asthma healthcare delivery; Discuss the impact and cost-effectiveness of school-based asthma interventions on health outcomes; Discuss the impact of asthma subspecialty care via telemedicine on health outcomes.

10:45 am to 12:00 pm Marriott North Tower, Lobby Level, Marriott Hall Salon 1 Credit: 1.25 CME / 1.50 CE Moderator: Debra A. Sedlak, MSN CPNP Panelists William R. Blouin, ARNP Vivian P. Hernandez-Trujillo, MD FAAAAI Gabriel Ortiz, MPAS PA-C Upon completion of this session, participants should be able to: Discuss how patients, teachers and members of the lay community can recognize the signs and symptoms of anaphylaxis; Discuss how to plan and use appropriate treatment.

Allied Health Workshop 2312 Atopic Dermatitis: Advancing Proficiency in Management

10:45 11:00 11:15

10:45 am to 12:00 pm Marriott North Tower, Lobby Level, Marriott Hall Salon 2 Pre-registration and ticket required. No fee. Credit: 1.25 CME / 1.50 CE Moderator: Pooja Varshney, MD Atopic Dermatitis: Immune Dysregulation Gregory M. Metz, MD Atopic Dermatitis: Management Strategies Karen L. Gregory, DNP APRN-BC RRT AE-C Hands-On Instruction

Upon completion of this session, participants should be able to: Discuss the complex immune dysregulation that occurs in atopic dermatitis; Describe the general concepts of managing atopic dermatitis; Identify signs and symptoms that warrant further investigation (food allergy, immune deficiency, secondary infections).

42

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

SATURDAY, MARCH 1 Allied Health Workshop

Allied Health Workshop

2313 Immune Replacement Therapy: The Route to Travel

2316 Using Technology to Improve Patient Adherence

10:45 11:00 11:15

10:45 am to 12:00 pm Marriott North Tower, Lobby Level, Torrey Pines 1 & 2 Pre-registration and ticket required. No fee. Credit: 1.25 CME / 1.50 CE Moderator: Ginger S. LaBelle, CPNP SCIG Kristin Epland, NP IVIG M. Elizabeth M. Younger, CRNP PhD Hands-On Instruction

11:30

Upon completion of this session, participants should be able to: Discuss the recognition of health literacy in patients and its impact on adherence to treatment plans; Review tools available for use in clinical practice; Discuss ways to utilize both social media and mobile devices to improve office and provider efficiency, patient engagement and overall care in the clinical setting.

Upon completion of this session, participants should be able to: Describe the pros and cons of both IV and SC therapy; Identify the supplies and devices used for SC infusions.

Allied Health Symposium 2314 The Contribution of Aerobiology Towards Asthma Morbidity

10:45

11:05 11:25 11:45

10:45 am to 12:00 pm Marriott North Tower, Lobby Level, Torrey Pines 3 Credit: 1.25 CME / 1.50 CE Moderator: David L. Rosenstreich, MD FAAAAI Association Between Tree Pollen Counts and Asthma ER Visits in a High-Density Urban Center Sunit Jariwala, MD The Impact of Mouse Allergen on Asthma Susan L. Balcer-Whaley, MPH Neighborhood Differences in Asthma Prevalence and Persistence Matthew S. Perzanowski, PhD Question & Answer

Upon completion of this session, participants should be able to: Describe the relationship between outdoor air quality components and asthma-related morbidities; Identify the effect mouse allergen contributes to asthma in an urban environment.

Allied Health Workshop 2315 Revenue Management with Correct Coding

11:30

10:45 am to 12:00 pm Marriott North Tower, Lobby Level, Atlanta Credit: 1.25 CME / 1.50 CE Moderator: John D. Milewski, Med. Admin. David R. Stukus, MD FAAAAI Question & Answer

10:45 am to 12:00 pm Marriott North Tower, Lobby Level, Chicago Credit: 1.25 CME / 1.50 CE Moderator: Joan E. Hawkins Teresa Thompson, CPC CMSCS CCC Question & Answer

Allied Health Professional Assembly Forum 12:30 to 1:30 pm Marriott North Tower, Lobby Level, Marriott Hall Salon 6 All allied health professionals are invited to attend this forum. Box lunches included.

Seminars 12:30 to 1:30 pm Pre-registration and ticket required. Fee: $40. Box lunch included. Sessions and meals are limited to 30 people. Credit: 1.00 CME / 1.20 CE

2501 The Evolution of Childhood Wheezing to Asthma Leonard B. Bacharier, MD FAAAAI Bradley E. Chipps, MD FAAAAI Marriott South Tower, Level 3, Marina Ballroom Salon D Upon completion of this session, participants should be able to: Determine the diagnostic criteria for varied phenotypic expression of childhood asthma; Examine the progression of immunopathologic events in the development of childhood asthma; Examine the implication for treatment given the varied immunopathologic and phenotypic expressions.

2502 Performing and Interpreting Spirometry: Understanding and Implementing the ATS/ERS Guidelines James M. Quinn, MD FAAAAI Kevin M. White, MD Marriott South Tower, Level 3, Marina Ballroom Salon E Upon completion of this session, participants should be able to: Identify the source and relevance of the ATS/ERS guidelines for lung function testing; Discuss the ATS/ERS recommendations for correct performance of spirometry; Identfy ATS/ERS guidelines to interpret spirometry and classify the severity of identified abnormalities.

Upon completion of this session, participants should be able to: List the current CPT guidelines; Describe the current information to code correctly to third party payer guidelines; Discuss the current information regarding reviews from CMS, OIG, RAC and third party payers.

2503 Hereditary Angioedema: Diagnosis and Management Mark S. Dykewicz, MD FAAAAI Andrew J. MacGinnitie, MD PhD Marriott South Tower, Level 3, Marina Ballroom Salon F Upon completion of this session, participants should be able to: Review the mechanism of HAE; Discuss how and when to use the new therapies for HAE; Describe how to improve outcomes of your patients with HAE.

Annual Meeting Seminars Programmed by the AAAAI. Annual Meeting Seminars funded through an educational grant from Merck.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

43

SATURDAY, MARCH 1 2504 Making the Most of Your EMR: Meeting Meaningful Use

2510 Quality Improvement and Patient Safety in Allergy Practice

Priya J. Bansal, MD FAAAAI A. Sean McKnight, MD FAAAAI Marriott South Tower, Level 3, Marina Ballroom Salon G Upon completion of this session, participants should be able to: Discuss tips for optimizing your current EMR; Discuss current state of Meaningful Use government incentive payments; Discuss clinical quality measures and PQRI reporting with your EMR.

2505 When Should Bone Marrow Transplantation be Considered in Primary Immunodeficiency? Rebecca A. Marsh, MD Elena E. Perez, MD PhD FAAAAI Marriott South Tower, Level 3, Balboa

Brad J. McClimon, MD Matthew A. Rank, MD FAAAAI Marriott South Tower, Level 1, Point Loma Upon completion of this session, participants should be able to: Discuss the need for allergists to consider, plan and perform quality projects; Discuss fundamental principles guiding quality improvement of allergic/immunologic diseases in the United States; Discuss potential quality improvement opportunities that could positively influence the outcomes of allergy, asthma and immunology education, research and patient care at the local and national level.

2511 Biologics Targeting the Immune Responses in Chronic Rhinosinusitis and Nasal Polyps

Upon completion of this session, participants should be able to: Review the primary immunodeficiency diseases for which BMT can be a curative treatment; Discuss how soon after diagnosis a patient with certain immunodeficiency disorders should be referred to a BMT center; Describe any therapies to be avoided prior to a patient going to transplant.

2506 Viral Infections in the Allergic Host: What Factors May Be Synergistic? Josh L. Kennedy, MD Eva Kathryn Miller, MD Marriott South Tower, Level 3, Mission Hills

Claus Bachert, MD PhD Daniel L. Hamilos, MD Marriott South Tower, Level 1, Solana Upon completion of this session, participants should be able to describe biologic treatments under consideration for treatment of chronic rhinosinusitis.

2512 Immunotherapy with Immunomodulator Therapy: Which Work and Which Do Not? Peter S. Creticos, MD FAAAAI Mohamed H. Shamji, BSc MSc PhD Marriott South Tower, Level 1, Santa Rosa

Upon completion of this session, participants should be able to: Evaluate the innate immune response to viral infection in the exacerbating asthmatic, particularly the evidence of a deficient or overactive response; Discuss the role of the epithelium in asthmatic responses to viral infection; Evaluate the role of allergy by examining the evidence that IgE responses are important predictors of asthma exacerbations.

Upon completion of this session, participants should be able to: Review new data on the combination of immunotherapy and certain immunomodulators; Discuss the the possible mechanisms that might account for these findings, analyzing the mechanisms of immunotherapy in a new light.

2507 Biomass Smoke: Alternative Energy or Pollutant Source?

2513 Evaluating Experimental Models of Allergic Rhinitis

Patricia Mason Fritz Alisa M. Smith, PhD FAAAAI Marriott South Tower, Level 3, Cardiff

Anne K. Ellis, MD MSc FAAAAI Martin Wagenmann, MD FAAAAI Marriott South Tower, Level 4, La Costa

Upon completion of this session, participants should be able to: Recognize the emergence of a potentially significant source of community (neighborhood) air pollution; Discuss the continuum and coherence of health effects from exposure to combustion emissions; Analyze the role of ambient air pollution on the health of non-urban populations.

2508 The Intricacy of Penicillin Allergy Evaluation Eric M. Macy, MD FAAAAI Miguel A. Park, MD Marriott South Tower, Level 3, Del Mar Upon completion of this session, participants should be able to: Discuss the different components of the penicillin skin test; Discuss how the different components of the penicillin skin test affect the negative predictive value; Discuss the role of oral challenges to penicillin and/or amoxicillin in the evaluation of penicillin allergy.

2509 Performance of Oral Food Challenges in the Office Setting S. Allan Bock, MD FAAAAI Justin M. Skripak, MD Marriott South Tower, Level 3, Miramar Upon completion of this session, participants should be able to: Describe and perform food challenges in their own practices; Review the practical aspects of how to carry out a typical food challenge in the office; Discuss how to select patients for extensively heated milk and egg challenges and how to perform those challenges.

Upon completion of this session, participants should be able to: Describe the most commonly used methodologies for experimental nasal allergen challenge in the investigation of allergic rhinitis; Describe the commonly used methodologies utilized in environmental exposure unit-type studies of allergic rhinitis; Describe the advantages and disadvantages of both experimental models pertaining to the study of allergic rhinitis.

2514 Food Allergy and the Mucosal B Cell Cathryn R. Nagler, PhD Duane R. Wesemann, MD PhD Marriott South Tower, Level 4, Catalina Upon completion of this session, participants should be able to: Discuss how commensal organisms and dietary antigens may shape the pre-immune antibody repertoire; Review the known mechanisms underlying immune tolerance to gut luminal antigens; Describe the mechanisms regulating antibody affinity maturation and IgH class switch recombination to IgE.

2515 Prostaglandins: Regulatory Lipid Mediators Darryl C. Zeldin, MD Weisong Zhou, PhD Marriott South Tower, Level 4, Coronado Upon completion of this session, participants should be able to: Define the role of prostaglandins in vascular remodeling and allergic lung inflammation; Describe the role of prostaglandins in regulating T cell differentiation and function; Describe the role of prostaglandins on allergen-induced immune tolerance.

Annual Meeting Seminars Programmed by the AAAAI. Annual Meeting Seminars funded through an educational grant from Merck.

44

Allied Health Session

ticket required

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included in the Virtual Annual Meeting

SATURDAY, MARCH 1 Pro/Con Debate

Pro/Con Debate

2521 NHLBI Guideline Adherence Leads to Improvements in Asthma Outcomes in Medical Center Homes

2524 The Microbiome is Important in Asthma

Programmed by the AAAAI and JCAAI. Honored through an educational grant from Robert J. Becker, MD, Joint Council of Allergy, Asthma and Immunology Memorial Lectureship Fund. 12:30 to 1:30 pm Convention Center, Mezzanine Level, Room 15AB Credit: 1.00 CME / 1.20 CE Moderator: Tao T. Le, MD MHS FAAAAI Pro Richard W. Honsinger, MD MACP FAAAAI Con Harvey L. Leo, MD FAAAAI Upon completion of this session, participants should be able to: Describe the role of quality measures in the development of ACA parameters; Identify limitations in guideline developments for chronic diseases like asthma; Develop novel ideas to promote the expertise of allergy/immunology’s role in active population based management of an important chronic disease.

Pro/Con Debate 2522 Bronchial Thermoplasty Has a Role in Severe Asthma Management 12:30 to 1:30 pm Convention Center, Upper Level, Ballroom 6A Credit: 1.00 CME / 1.20 CE Moderator: Mark F. Sands, MD FAAAAI Pro Mario Castro, MD MPH Con William J. Calhoun, MD FAAAAI

12:30 to 1:30 pm Convention Center, Upper Level, Ballroom 6CF Credit: 1.00 CME / 1.20 CE Moderator: R. Stokes Peebles, Jr., MD FAAAAI Pro Homer A. Boushey, MD FAAAAI Con Thomas A.E. Platts-Mills, MD PhD FAAAAI Upon completion of this session, participants should be able to: Define the human microbiome; Discuss the relevance of the human microbiome to allergic disease, particularly as it relates to asthma; Discuss possible alterations to the microbiome that might be useful in asthma therapy.

Pro/Con Debate 2525 Biopsy is Necessary for Follow-up of EoE 12:30 to 1:30 pm Convention Center, Upper Level, Ballroom 6DE Credit: 1.00 CME / 1.20 CE Moderator: Katrina Jane Allen, MD PhD FAAAAI Pro Jonathan M. Spergel, MD PhD FAAAAI Con Mirna Chehade, MD MPH Upon completion of this session, participants should be able to: List the arguments supporting the assertion that endoscopy is necessary for monitoring EoE; Discuss the arguments suggesting that you can follow EoE patients by symptoms; Discuss the relevance of endoscopies and symptom scores in evaluating and managing patients with esophageal eosinophilia.

Pro/Con Debate

Upon completion of this session, participants should be able to: Recognize the risk and benefit of bronchial thermoplasty (BT) in asthma management; Describe the indications and contraindications for BT; Describe the outcomes of major clinical trials for BT.

Pro/Con Debate 2523 Component Resolved Diagnosis Can Predict Anaphylactic Reactions to Peanut 12:30 to 1:30 pm Convention Center, Upper Level, Ballroom 6B Credit: 1.00 CME / 1.20 CE Moderator: Stacie M. Jones, MD Pro Joerg R. Kleine-Tebbe, MD FAAAAI Con Anna H. Nowak-Wegrzyn, MD FAAAAI

2526 Bone Marrow Biopsy is Indicated in Idiopathic Anaphylaxis 12:30 to 1:30 pm Convention Center, Upper Level, Room 11AB Credit: 1.00 CME / 1.20 CE Moderator: Phillip L. Lieberman, MD FAAAAI Pro Mariana C. Castells, MD PhD FAAAAI Con Paul A. Greenberger, MD FAAAAI Upon completion of this session, participants should be able to: Name the current information related to mast cell activation syndrome and idiopathic anaphylaxis; Discuss the primary and secondary triggers of mast cell activation syndrome and anaphylaxis; List the current treatment guidelines of mast cell activation syndrome and idiopathic anaphylaxis.

Upon completion of this session, participants should be able to: Describe the significance of molecular testing as an indicator for food allergen challenge.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

45

SATURDAY, MARCH 1 Pro/Con Debate

Oral Abstract

2527 All Patients with Recurrent Sinus Infections Should be Screened for Immunodeficiencies

2602 Mechanisms and Immunotherapy

12:30 to 1:30 pm Convention Center, Upper Level, Room 30ABCDE Credit: 1.00 CME / 1.20 CE Moderator: John M. Routes, MD FAAAAI Pro Vincent R. Bonagura, MD FAAAAI Con Todd T. Kingdom, MD

2:00

2:15

Upon completion of this session, participants should be able to: List the differential diagnosis of recurrent or chronic sinusitis in adults; Identify appropriate immunodeficiency screening measures in recurrent/chronic sinusitis and patients that would benefit from screening.

2:30

Oral Abstract 2:45

2601 Novel Genetic Factors in Asthma

2:00

2:15

2:30

2:45

3:00

2:00 to 3:15 pm Convention Center, Upper Level, Ballroom 6A Credit: 1.25 CME / 1.50 CE Moderator: Paula L. Busse, MD FAAAAI IL-33 and IL1RL1 Single Nucleotide Polymorphisms and Their Association With Asthma Among Puerto Ricans Javier A. Mendez, MD Genetic Effect Of Single-Nucleotide Polymorphisms In The PPARGC1B Gene On Airway Hyperreactivity In Asthmatic Patients Jong-Sook Park, MD Polymorphisms In IL10, TGFB, TLR4, TLR8 and ADBR2 Genes Resulted Associated To Asthma In Brazilian Family Trio Study Isabel Ruguê Genov, MD Genetic Variation Along The Histamine Pathway In Children With Allergic Vs. Non-Allergic Asthma Sara Anvari, MD Association Of Polymorphism At The CD14 Promoter (CD14C159T) With Atopic and Non-Atopic Asthma In Adults From Crimea, Ukraine Yuri Bisyuk

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

3:00

2:00 to 3:15 pm Convention Center, Upper Level, Ballroom 6CF Credit: 1.25 CME / 1.50 CE Moderator: Ricardo U. Sorensen, MD The Utility Of Anti-Pneumococcal Antibody Measurement In Patients With Primary Immunodeficiency Receiving Immunoglobulin Stephen Jolles Diagnostic Immunization With Bacteriophage ΦX 174 In Patients With Common Variable Immunodeficiency/ Hypogammaglobulinemia Lauren Smith, MD Immunochip Study Reveals Regions On Chromosomes 2 and 6 May Contribute To The Spectrum Of CVID Tracy Hwangpo, MD PhD Rule Of Different Memory Cells In Common Variable Immunodeficiency and Specific Antibody Deficiency Amer M. Khojah, MD Evaluation of a Novel Missense Activation-Induced Deaminase AID Mutation in a Child with Hyper IgM Syndrome: Is it a Pathogenic Mutation? Ottavia M. Delmonte, MD

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Oral Abstract 2603 Asthma Environmental Risk Factors and Infections

2:00

2:15 2:30

2:45

3:00

2:00 to 3:15 pm Convention Center, Mezzanine Level, Room 14AB Credit: 1.25 CME / 1.50 CE Moderator: Daniel Elkayam, MD Surfactant Protein A (SP-A) Reduces Human Rhinovirus 16 (RV16)-Induced Inflammatory Responses In Bronchial Epithelial Cells and Inhibits Viral Replication In H1-HeLa Cells Sasipa Tanyaratsrisakul, PhD The Home Microbiome and Childhood Asthma Christina E. Ciaccio, MD FAAAAI Effect Of Prenatal Antioxidant Intake On Infants’ Respiratory Infection Eun Lee Epidermal Growth Factor Receptor (EGFR) Mediates Cell Fusion and Infectivity Of Respiratory Syncytial Virus (RSV) Sujin Lee Cluster Analysis Of An Inner-City Cohort Of Infant Wheezers Monica B. Reddy, MD

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

46

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

SATURDAY, MARCH 1 Oral Abstract

Oral Abstract

2604 Atopic Dermatitis

2606 Local Allergic Rhinitis and Non-Allergic Rhinitis

2:00

2:15

2:30

2:45

3:00

2:00 to 3:15 pm Convention Center, Upper Level, Ballroom 6B Credit: 1.25 CME / 1.50 CE Moderators: Lisa A. Beck, MD FAAAAI Peck G. Ong, MD FAAAAI A Randomized, Multi-Center, NIH/NIAID Funded Study To Assess The Immunogenicity Of Fluzone® Intradermal and Intramuscular Vaccines In Atopic Dermatitis Donald Y.M. Leung, MD PhD FAAAAI Which Infants With Eczema Are At Risk Of Food Allergy? Results From A Population Based Study Jana K. Eckert, PhD Exome Chip Genotyping Reveals Association With PDE4C and Atopic Dermatitis In Populations Of European and African Descent Nicholas M. Rafaels Exploring a Role for Laminin Proteins in the Pathogenesis of Atopic Dermatitis Erin J. Klaffky, MD PhD Thymic Stromal Lymphopoietin and Interleukin-33 Promote Skin Inflammation and Containment Of Vaccinia Virus In A Mouse Model Of Atopic Dermatitis Michiko K. Oyoshi, PhD MSc

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

2:00

2:15

2:30 2:45

3:00

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Oral Abstract 2607 Mechanisms of Steroid and Arachidonic Acid Pathways in Allergic Disease

Oral Abstract 2605 Health Disparities

2:00

2:15

2:30

2:45

3:00

2:00 to 3:15 pm Convention Center, Upper Level, Room 1AB Credit: 1.25 CME / 1.50 CE Moderators: Melody C. Carter, MD Princess U. Ogbogu, MD FAAAAI What Really Happens In The Home: The Medication Environment Of Urban, Minority Youth Molly Martin, MD MAPP Young, African American Adults With Asthma: What Matters To Them? Aimee L. Speck, MD Language Disparities Among Minority Patients with Poor Asthma Control Jose R. Zaragoza-Buxo, MD Race/Ethnicity and SES Are Predictors Of Allergic Sensitization To Environmental and Food Allergens Amina Abdeldaim, MD Unrecognized Allergic Rhinoconjunctivitis and Allergic Sensitization Among Latino Youth (GALA II Study) Ulysses Burley, MPH

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Allied Health Session

ticket required

fee required

2:00 to 3:15 pm Convention Center, Upper Level, Ballroom 6DE Credit: 1.25 CME / 1.50 CE Moderator: Joaquim Mullol, MD PhD FAAAAI The Nasal NO Response To External Acoustic Energy: A Pilot Study Dennis Shusterman, MD MPH Flagellin/Toll-Like Receptor 5 Induces Interleukin-17C In Human Nasal Epithelia Hyun Jin Min Phenotyping Non-Allergic and Local Allergic Rhinitis Carmen Rondon, MD PhD Role Of Basophil Activation Test For Identifying Subjects With Local Allergic Rhinitis Paloma Campo, MD PhD Does Serum Leptin Differ Between Patients With Rhinitis Of Allergic Vs Nonallergic Aetiology? Ayse Fusun Kalpaklioglu, MD

2:00

2:15

2:30

2:45

3:00

2:00 to 3:15 pm Convention Center, Mezzanine Level, Room 16AB Credit: 1.25 CME / 1.50 CE Moderators: Larry Borish, MD FAAAAI Dawn C. Newcomb Baker, PhD LTC4, But Not LTD4 Or LTE4, Activates Platelets Through a CysLT2R and P2Y12 Receptor-Dependent Pathway Joshua A. Boyce, MD FAAAAI Predictors Of Response To Glucocorticoids In Hypereosinophilic Syndromes Paneez Khoury, MD Differential Proteomic Analysis Of Eosinophils From Patients With Glucocorticoid Responsive Or Resistant Hypereosinophilic Syndrome Konrad Pazdrak, MD PhD Glucocorticoid Receptor-â Up-Regulation In C57BL/6 DietInduced Obese Mice With House Dust Mite-Mediated Asthma Jennifer Diaz, MD Reduced EP2 Receptor Expression Accounts For Prostaglandin E2 Resistance In Nasal Polyp Fibroblasts From Patients With Aspirin Exacerbated Respiratory Disease; Possible Role For Histone Acetylation In Control Of EP2 Receptor Expression Katherine N. Cahill, MD

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

included in the Virtual Annual Meeting

47

SATURDAY, MARCH 1 Symposium

Allied Health Workshop

2611 SLIT: Implementation in Your Practice

2623 ICD-10CM: Dispelling the Fear

2:00 2:20 2:40 3:00

2:00 to 3:15 pm Convention Center, Ground Level, Exhibit Hall A Credit: 1.25 CME / 1.50 CE A recording of this session will be available online free of charge to registered attendees following the Annual Meeting. Moderators: Désirée E.S. Larenas Linnemann, MD FAAAAI Michael S. Tankersley, MD FAAAAI Therapeutic Mechanisms of SLIT Stephen R. Durham, MA MD FRCP SLIT Approval Trials in the U.S. Thomas B. Casale, MD FAAAAI SLIT in Practice: The Nuts and the Bolts of Using it Linda Cox, MD FAAAAI Question & Answer

2:45

Upon completion of this session, participants should be able to: Identify the documentation requirements for the ICD-10CM system; Review the guidelines for choosing the correct diagnosis code for ICD-10; Discuss the timelines and the effects on the entire allergy practice.

Allied Health Symposium 2624 Data Management: Taking Your Data from Collection to Analysis

Upon completion of this session, participants should be able to: Review how SLIT works; Discuss the results of pivotal SLIT clinical trials; Describe how to use SLIT in practice.

Allied Health Workshop 2621 Patient Safety in Allergy Practices: Is it an Issue?

2:00 2:30

2:00 to 3:15 pm Marriott North Tower, Lobby Level, Marriott Hall Salon 1 Credit: 1.25 CME / 1.50 CE Moderator: John D. Milewski, Med. Admin. Malpractice: Risk Assessment Donald W. Aaronson, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Identify potential causes of patient injury due to allergy care; List actions that can prevent patient injury in an allergy practice; Discuss the risks of allergy immunotherapy and how to design practices that will reduce medical errors related to allergen immunotherapy that result in patient injury.

2:00 to 3:15 pm Marriott North Tower, Lobby Level, Torrey Pines 1 & 2 Credit: 1.25 CME / 1.50 CE Moderator: Joan E. Hawkins Teresa Thompson, CPC CMSCS CCC Question & Answer

2:00 2:20 2:40 3:00

2:00 to 3:15 pm Marriott North Tower, Lobby Level, Torrey Pines 3 Credit: 1.25 CME / 1.50 CE Moderator: Patrick J. Lenehan, MD Data Collection: The First Part of a Long Process Patrick J. Lenehan, MD Data Cleaning: Reviewing and Reflecting on Study Variables Charles Aloe, MPH Data Analysis: Identifying the True Message Jean Curtin-Brosnan, MA Question & Answer

Upon completion of this session, participants should be able to: Discuss strategies for collecting and storing data completely and accurately; Describe the process of cleaning data and preparing it for analysis; Identify how changes in data can affect analytical results.

Allied Health Symposium 2622 Taking a Food Allergy History for the Advanced Practice Provider: The Key to Diagnosis

2:00

2:30 3:00

2:00 to 3:15 pm Marriott North Tower, Lobby Level, Marriott Hall Salon 2 Credit: 1.25 CME / 1.50 CE Moderator: Pamela H. Steele, MSN CPNP AE-C Obtaining a Complete and Concise Food Allergy History from Your Patients Maria G. Crain, CPNP AE-C Interpreting the History to Guide Your Use of Diagnostic Testing Katie J. Atkinson, RN CFNP Question & Answer

Upon completion of this session, participants should be able to: Describe a complete food allergy history; Discuss a concise diet history; Interpret patient information to guide testing.

48

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

SATURDAY, MARCH 1 Allied Health Workshop

Keynote

2625 Allied Health Workshop: Travel Scholarship Award Recipients

2701 Genomic and Wireless Digital Innovation: Reshaping the Future of Medicine

2:00 2:05 2:10 2:15 2:20 2:25 2:30

2:35 2:40

2:45

2:50

2:55

2:00 to 3:15 pm Marriott North Tower, Lobby Level, Atlanta Credit: 1.25 CME / 1.50 CE Moderator: Stephen J. McGeady, MD FAAAAI Case Study of a Successful Asthma Network Karen L. Meyerson, MSN FNP-C AE-C AsthmaCare Partners Program Julie A. Kuhn, MSW Patient Satisfaction Surveys (Research) Diane G. Ananos, RN Five Years of FOIT (Food Oral Immunotherapy) in Private Practice Angela Hague, PA-C Developing Support Groups for Patients with EGID Raquel Z. Durban, MS RD LDN Bridging the Gap: Gaps in the World of Food Protein Entercolitis Fallon Schultz, MSW LCSW CAM Understanding Barriers and Support in Asthma Management in School Age Children Helena Azzi, DNP FNP-BC AE-C Indentifying Dietary Interventions in EoE Anna C. Sprunger, PA-C Strengthening Physicians' Ability to Convey Information to Patients Edward M. Horowitz, BA Effietive Program Planning Program Workshop for Asthma Educators Margaret J. McCormick, MS RN Surprising Benefits of Omalizumab in a Patient with Mixed Disease Asthma/COPD A Case Study in Knoxville, Tennessee Laura E. Odom, MSN FNP Question & Answer

Upon completion of this session, participants should be able to: Develop an appreciation for the activities of Allied Health members that contribute to the care of patients; Identify effective patient care strategies that can be implemented into the allergy/immunology practice; Develop professional networks within Allied Health.

3:30 to 4:30 pm Convention Center, Ground Level, Exhibit Hall A Credit: 1.00 CME / 1.20 CE Moderator: Stuart L. Abramson, MD PhD FAAAAI Eric J. Topol, MD Cardiologist, Scripps La Jolla, California; Professor of Genomics at the Scripps Research Institute and Chief Academic Officer of Scripps Health; and Editor-in-Chief at Medscape Upon completion of this session, participants should be able to describe how genomics and digital technologies can be utilized in the development and implementation of medical management plans.

Q & A Workshop 2801 The Influence of Bisphenol A and Phthalates (Xenoestrogens) on the Development of Asthma and Allergy in Children and Adults: What’s Known and What’s Real?

4:45

5:00

5:15

5:30

4:45 to 6:00 pm Convention Center, Upper Level, Room 1AB Credit: 1.25 CME / 1.50 CE Moderator: Leslie C. Grammer, MD FAAAAI How Are We Exposed to Bisphenol A and Phthalates in Our Immediate and Regional Environments? Randall M. Goldblum, MD What Can Basic Research Teach Us About the Effects of Xenoestrogens on Allergy and Asthma? Terumi Midoro-Horiuti, MD PhD FAAAAI What Have We Observed About the Effects of Xenoestrogens on the Development of Childhood and Adult Asthma and Allergy? Rachel L. Miller, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Define the environmental sources of chemicals with estrogen properties such as bisphenol A and phthalates; Summarize the research demonstrating the effects of xenoestrogens on the allergic and asthmatic phenotype; Describe the epidemiology that associates xenoestrogen exposures and the development of asthma and allergy in children and adults.

Annual Meeting Workshops Programmed by the AAAAI. Annual Meeting Workshops funded through an educational grant from Merck.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

49

SATURDAY, MARCH 1 Hands-On Workshop

Q & A Workshop

2802 EMR Roundtable: What Are Allergists Using?

2804 The Safety of Asthma Medications During Pregnancy: An Update

4:45 to 6:00 pm Convention Center, Upper Level, Room 2 Pre-registration and ticket required. Fee: $50. Credit: 1.25 CME / 1.50 CE Moderator: Tao T. Le, MD MHS FAAAAI Practice Fusion Dana V. Wallace, MD FAAAAI GE Centricity A. Sean McKnight, MD FAAAAI Allscripts Melinda M. Rathkopf, MD FAAAAI EPIC Ves Dimov, MD Meditab-IMS Richard L. Wasserman, MD PhD FAAAAI NextGen Robert Anolik, MD FAAAAI ModuleMD Instructor to be announced. eClinical Works Hugh H. Windom, MD FAAAAI Rosch Nathaniel D. Hare, MD FAAAAI

4:45

5:00

5:15

5:30

4:45 to 6:00 pm Convention Center, Upper Level, Room 11AB Credit: 1.25 CME / 1.50 CE Moderator: Michael Schatz, MD MS FAAAAI The Safety of Asthma Medications During Pregnancy: VAMPSS Prospective Cohort Data Christina Chambers, PhD MPH The Safety of Asthma Medications During Pregnancy: VAMPSS Case-Control Data Allen A. Mitchell, MD A Synthesis of Data on the Safety of Asthma Medications During Pregnancy Jennifer A. Namazy, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Evaluate the recent VAMPSS prospective cohort data on the safety of asthma medications in pregnancy; Review the recent VAMPSS case-control data on the safety of asthma medications in pregnancy; Discuss current information on the gestational safety of asthma medications to the clinical care of pregnant patients with asthma.

Reception immediately following the session with the VAMPSS Investigative Team.

Q & A Workshop

Upon completion of this session, participants should be able to: Discuss the challenges allergists face in EMR selection; Discuss tips on EMR selection and implementation specific to the practicing allergist; Review specific EMRs with allergists using them in practice.

2805 AAP: Hot Topics in Pediatric Allergy and Immunology

Problem-Based Learning Workshop 2803 A Child with Severe Atopic Dermatitis 4:45 to 6:00 pm Convention Center, Upper Level, Room 3 Pre-registration and ticket required. Fee: $50. Credit: 1.25 CME / 1.50 CE PBL Facilitator: Stanley M. Fineman, MD MBA FAAAAI Content Lecturer: Mark Boguniewicz, MD FAAAAI

4:45 5:00 5:15

Upon completion of this session, participants should be able to: Discuss the differential diagnosis of severe atopic dermatitis; Assess food allergy as a co-morbid condition in this patient; Summarize cutting-edge literature on state of the art skin therapy in refractory atopic dermatitis.

5:30

4:45 to 6:00 pm Convention Center, Upper Level, Ballroom 6A Credit: 1.25 CME / 1.50 CE Moderator: Todd A. Mahr, MD FAAAAI Allergic Respiratory Disease Chitra Dinakar, MD FAAAAI Food and Drug Allergies Brian P. Vickery, MD FAAAAI Immunologic Disorders Thomas A. Fleisher, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Describe the latest developments in pediatric allergy and immunology; Discuss how these might impact the care of pediatric patients with respiratory allergic disease, food and drug allergy and immunologic disorders.

Annual Meeting Workshops Programmed by the AAAAI. Annual Meeting Workshops funded through an educational grant from Merck.

50

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

SATURDAY, MARCH 1 Q & A Workshop

Q & A Workshop

2806 Who’s on First? Primary Immunodeficiency, Autoimmune Disease or Immune Modulation

2809 Update in Occupational Allergy: A Focus on the Skin, Nose, and the Young Worker

4:45

5:00 5:15

5:30

4:45 to 6:00 pm Convention Center, Upper Level, Ballroom 6B Credit: 1.25 CME / 1.50 CE Moderator: Ramsay L. Fuleihan, MD Autoimmune Disease with Primary and Secondary Failure of Tolerance Speaker to be announced. Infectious Complications of Immune Modulation Christina C. Price, MD Monitoring and Supporting Immune Function After Immunomodulation Vibeke Strand, MD Question & Answer

Upon completion of this session, participants should be able to: Discuss how autoimmunity arises in the setting of primary and secondary immunodeficiency; Review potential infectious sequelae arising from immunomodulation; Describe how to monitor and support immune function after immune compromise due to immunomodulator therapy.

Q & A Workshop 2807 Difficult Drug Allergy Cases: Case-Based Discussions

4:45 5:00

5:15

5:30

4:45 to 6:00 pm Convention Center, Upper Level, Ballroom 6CF Credit: 1.25 CME / 1.50 CE Moderator: Rebecca S. Gruchalla, MD PhD FAAAAI Management of Patients with Multiple Drug Allergies Roland Solensky, MD FAAAAI Perioperative Anaphylaxis and Advice for Patients Needing Further Surgery Aleena Banerji, MD Determine When Skin Testing, Test Doses and Desensitization are Appropriate David A. Khan, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Explain management of patients with multiple drug allergies; Describe perioperative anaphylaxis: diagnosis, evaluation and management; Identify the role for skin testing, test dose and desensitization.

Panel Discussion Workshop 2808 Thriving and Surviving in the Evolving Healthcare System: 2014 JCAAI Update 4:45 to 6:00 pm Convention Center, Upper Level, Ballroom 6DE Credit: 1.25 CME / 1.50 CE Moderator: J. Allen Meadows, MD FAAAAI Panelists: Donald W. Aaronson, MD FAAAAI Gary N. Gross, MD FAAAAI Richard W. Honsinger, MD MACP FAAAAI Upon completion of this session, participants should be able to: List strategies for positioning their practices for success in the changing healthcare arena; Describe the changing allergy CPT codes, ICD-10 changes and other new coding developments; Discuss the requirements for compliance with federal regulations, including penalties for non-compliance.

Allied Health Session

ticket required

fee required

4:45

5:00 5:15

5:30

4:45 to 6:00 pm Convention Center, Upper Level, Room 7AB Credit: 1.25 CME / 1.50 CE Moderator: Susan M. Tarlo, MBBS FAAAAI Skin Prick Testing in the Diagnosis of Occupational Type I Allergies Joaquin Sastre, MD PhD FAAAAI Occupational Rhinitis Santiago Quirce, MD PhD Prevention of Work-Related Respiratory Allergies in Young Workers André Cartier, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Review the pros and cons of skin testing for occupational allergens and recent advances in occupational skin allergy; Identify the range of exposures causing occupational rhinitis and tools for investigation; Discuss how to approach adolescents and young adults at risk of work-related allergic responses.

Q & A Workshop 2810 Molecular Pathogenesis of Aspirin Intolerance

4:45

5:00 5:15 5:30

4:45 to 6:00 pm Convention Center, Upper Level, Room 8 Credit: 1.25 CME / 1.50 CE Moderator: Robert P. Schleimer, PhD FAAAAI Prostaglandin E2 Resistance: An Explanation for Dysregulation of Leukotrienes in AERD Tanya M. Laidlaw, MD FAAAAI Chronic Rhinosinusitis and Disturbed Microbial Homeostasis Susan V. Lynch, PhD The Surprising Role of Interferon Gamma in AERD Larry Borish, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Identify the molecular control mechanisms of the 5-lipoxygenase enzyme; Identify the potential contribution from the perturbed microbiome; Discuss the potential role of inteferon gamma in AERD.

Panel Discussion Workshop 2811 Experimental Models of Allergic Rhinitis: Evaluation and Utilization 4:45 to 6:00 pm Convention Center, Upper Level, Room 5AB Credit: 1.25 CME / 1.50 CE Moderator: Fuad M. Baroody, MD FAAAAI Panelists: Anne K. Ellis, MD MSc FAAAAI Robert M. Naclerio, MD FAAAAI Martin Wagenmann, MD FAAAAI Upon completion of this session, participants should be able to: Describe the commonly used methodologies utilized in environmental exposure unit-type studies of allergic rhinitis; Describe the most commonly used methodologies for experimental nasal allergen challenge in the investigation of allergic rhinitis; List the advantages and disadvantages of both experimental models pertaining to the study of allergic rhinitis.

included in the Virtual Annual Meeting

51

SATURDAY, MARCH 1 Q & A Workshop

Q & A Workshop

2812 Safety Challenges with Allergen Immunotherapy

2814 ABAI: Help Me Help You Meet MOC Requirements

4:45

5:00

5:15

5:30

4:45 to 6:00 pm Convention Center, Mezzanine Level, Room 14AB Credit: 1.25 CME / 1.50 CE Moderator: Matthew A. Rank, MD FAAAAI Allergen Immunotherapy in Patients with Other Special Medical Conditions Désirée E.S. Larenas Linnemann, MD FAAAAI Immunotherapy and Medication: Lessons Learned from Experience on How to Approach these Patients Christopher W. Calabria, MD Which Factors Might Enhance Safety of Immunotherapy in Your Clinic? David I. Bernstein, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Discuss safety experience with allergen immunotherapy given to patients with a history of cancer, HIV positivity, hypertension and other underlying medical conditions; Describe problems that might arise theoretically and problems that have been reported with AIT in patients taking certain medications (beta-blockers, ACE inhibitors, immunosuppressive drugs, etc.); Recognize factors in an allergy clinic associated with a higher rate of adverse events with AIT and recommend actions in their clinics that might augment safety of AIT.

4:45

5:00 5:15 5:30

Upon completion of this session, participants should be able to: Review the MOC requirements and how to successfully complete them; Demonstrate tips and tricks to completing MOC requirements; Reflect upon the personal experience of a peer who completed MOC requirements.

Q & A Workshop 2815 The Next Step After ICS/LABA

Q & A Workshop 2813 The Epithelium in Control

4:45 5:00 5:15

5:30

4:45 to 6:00 pm Convention Center, Mezzanine Level, Room 15AB Credit: 1.25 CME / 1.50 CE Moderator: Angela Haczku, MD PhD FAAAAI TSLP, Here We Go Again! Steven Ziegler, PhD The Importance of IL-25 Hirohito Kita, MD Epithelial and Dendritic Cell-Derived IL-33 in Control of Allergic Disease Anne Sperling, PhD Question & Answer

Upon completion of this session, participants should be able to: Describe novel mechanisms through which epithelial TSLP drives allergic disease; Discuss the mechanism through which epithelial derived IL-25 drives allergic disease; Discuss how the epithelium through IL-1a is able to drive allergic disease.

4:45 5:00 5:15 5:30

52

4:45 to 6:00 pm Convention Center, Upper Level, Room 30ABCDE Credit: 1.25 CME / 1.50 CE Moderator: Harold S. Nelson, MD FAAAAI The Case for Anti-Cholinergics Brian J. Lipworth, MD The Case for Fine Particle ICS Richard J. Martin, MD The Case for Omalizumab Thomas B. Casale, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: List the evidence supporting the use of anticholinergic therapy in refractory asthma; Review the evidence supporting the use of a small particle ICS over conventional ICS molecules; Discuss recent evidence supporting the use of omalizumab treatment in difficult asthma.

Problem-Based Learning Workshop 2816 Controversies in a Patient with Insect Sting Anaphylaxis 4:45 to 6:00 pm Convention Center, Upper Level, Room 31C Pre-registration and ticket required. Fee: $50. Credit: 1.25 CME / 1.50 CE PBL Facilitator: Ray S. Davis, MD FAAAAI Content Lecturer: David B.K. Golden, MD FAAAAI

Annual Meeting Workshops Programmed by the AAAAI. Annual Meeting Workshops funded through an educational grant from Merck.

4:45 to 6:00 pm Convention Center, Mezzanine Level, Room 16AB Credit: 1.25 CME / 1.50 CE Moderator: Stephen I. Wasserman, MD FAAAAI What’s New and What Do I Have to Do to Meet MOC Requirements? Rayné Harrison Roadblocks to Meeting MOC Requirements Sarah Johnson How I Survived Meeting MOC Requirements James M. Tracy, DO FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Discuss a case vignette of a patient with stinging insect anaphylaxis; Apply the latest Practice Parameters in the management of a challenging patient with insect venom anaphylaxis; Determine criteria for when to discontinue venom immunotherapy.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

SATURDAY, MARCH 1 Allied Health Workshop

Allied Health Workshop

2821 Anaphylaxis: Advancing Proficiency in Recognition, Management and Risk Reduction

2824 Myth Busters: Using Evidence-Based Medicine to Dispel Your Patient’s Allergy-Related Urban Myths

4:45 5:00 5:15

4:45 to 6:00 pm Marriott North Tower, Lobby Level, Torrey Pines 1 & 2 Pre-registration and ticket required. No fee. Credit: 1.25 CME / 1.50 CE Moderator: Dee Mallam, RN AE-C Anaphylaxis: Recognition and Treatment Gregory M. Metz, MD Anaphylaxis: Risk Reduction Strategies Karen L. Gregory, DNP APRN-BC RRT AE-C Hands-On Instruction

5:30

Upon completion of this session, participants should be able to: Discuss the criteria for anaphylaxis; Identify signs and symptoms of anaphylaxis and understand appropriate treatment; Describe risk factors for anaphylaxis and implement risk reduction strategies.

Allied Health Workshop 2822 Paths to Empowerment: Motivation and Cost-Effective Incentives in an Economically Challenging Environment

5:30

4:45 to 6:00 pm Marriott North Tower, Lobby Level, Marriott Hall Salon 2 Credit: 1.25 CME / 1.50 CE Moderator: John D. Milewski, Med. Admin. Jeanette Booker Question & Answer

Upon completion of this session, participants should be able to: Identify how to assess level of motivation in current employees; Discuss how to improve motivation and increase productivity; Outline how to change the culture in their practices and look at alternative incentives that are cost effective and reap positive results.

Allied Health Workshop 2823 Performing a Practice Assessment

5:30

4:45 to 6:00 pm Marriott North Tower, Lobby Level, Marriott Hall Salon 1 Credit: 1.25 CME / 1.50 CE Moderator: Joan E. Hawkins Thomas J. Derrico Question & Answer

Upon completion of this session, participants should be able to: Discuss the importance of a periodic assessment of their practices operational and financial performance; Identify key areas for consideration in performing an assessment; Describe sources of data from within their practices and how to obtain the data.

4:45 to 6:00 pm Marriott North Tower, Lobby Level, Torrey Pines 3 Credit: 1.25 CME / 1.50 CE Moderator: Jeanette L. Arnold, MSN RN C-FNP David R. Stukus, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Discuss commonly held misconceptions in the field of allergy/immunology; Analyze the evidence that refutes these commonly held misconceptions; Describe information that can be utilized in clinical practice to address frequently asked questions received from referring providers and patients.

Allied Health Workshop 2825 Managing the Complexities of the Food ProteinInduced Enterocolitis Syndrome Diet

5:25

4:45 to 6:00 pm Marriott North Tower, Lobby Level, Atlanta Credit: 1.25 CME / 1.50 CE Moderator: G. Lynn Christie, MS RD Kathryn E. Grimshaw, PhD RD Carina Venter, PhD RD Question & Answer

Upon completion of this session, participants should be able to: Identify foods commonly associated with FPIES; Describe the typical feeding progression in infancy and how to provide appropriate foods to promote feeding skill development with a very limited diet; Discuss specific nutritional risks associated with a limited solid foods diet in infancy and how to prevent/correct deficiencies in these diets.

New Allergist/Immunologist Assembly Business Meeting and Reception 4:45 to 6:15 pm Convention Center, Upper Level, Room 31AB The AAAAI invites all new allergy/immunology specialists to attend this business meeting and reception.

Chrysalis Project Reception 6:00 to 7:00 pm Marriott North Tower, Lobby Level, Rancho Santa Fe 1-3 Private reception open to Chrysalis project participants, mentors, faculty, and the Program Directors Assembly.

The Allergy, Asthma & Immunology Education and Research Organization (ARTrust™) “First Class Event” 7:00 to 10:00 pm San Diego Air & Space Museum All AAAAI members, delegates and guests are invited to attend this Saturday evening event. See page 13 for more information.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

53

Save the Date

2015

AAAAI Annual Meeting

February 20-24

Houston

Texas

American Academy of Allergy, Asthma & Immunology

SUNDAY, MARCH 2 3007 Environmental Microbiomes

Seminars 7:00 to 8:00 am Pre-registration and ticket required. Fee: $40. Continental breakfast included. Sessions and meals are limited to 30 people. Credit: 1.00 CME / 1.20 CE

3001 Treating the Patient with Difficult to Treat Exercise-Induced Asthma: Novel Therapies for Exercise-Induced Bronchoconstriction Matteo W. Bonini, MD William W. Storms, MD FAAAAI Marriott South Tower, Level 3, Marina Ballroom Salon D Upon completion of this session, participants should be able to: Outline current therapies for exercise-induced bronchoconstriction and acknowledge that some patients do not respond to them; Describe novel therapies for exercise-induced bronchoconstriction; Explain why beta agonists do not work for all patients with exercise-induced bronchoconstriction.

3002 Use of Cytokine Inhibitors in Severe Asthma Jonathan Corren, MD Sally E. Wenzel, MD FAAAAI Marriott South Tower, Level 3, Marina Ballroom Salon E Upon completion of this session, participants should be able to: Review and understand the roles that specific cytokines play in asthma; Review trials of various agents (anti-TNF, anti-IL4, anti-IL13, anti-IL5, anti-IL17, anti-IL9) in asthma; Explore subtypes of asthma where these agents might best be used.

3003 How Many Eosinophils are Too Many? Paneez Khoury, MD Princess U. Ogbogu, MD FAAAAI Marriott South Tower, Level 3, Marina Ballroom Salon F Upon completion of this session, participants should be able to: Review the criteria for eosinophilia; Discuss the differential diagnosis of eosinophilia; Review the work-up for an increased eosinophil count.

3004 Social Media for Allergy/Immunology Practice: Let’s Do It! Sakina S. Bajowala, MD FAAAAI Nathaniel D. Hare, MD FAAAAI Marriott South Tower, Level 3, Marina Ballroom Salon G Upon completion of this session, participants should be able to: Discuss how to set up a Twitter account and how to use it to connect with patients and colleagues; Discuss how to set up a Facebook professional page; Describe how to use YouTube to embed and record videos to maintain an interactive website for your practice.

3005 Update on Testing for Primary Immunodeficiency Diseases John M. Routes, MD FAAAAI Kathleen E. Sullivan, MD PhD FAAAAI Marriott South Tower, Level 3, Balboa

3006 Let’s Take the Myth-stery Out of Mold

Upon completion of this session, participants should be able to: Provide evidence that the risk of mold is often overstated, misstated or misunderstood; Learn of the true risk presented by mold; Explore issues with mold assessments and everyday mold exposure.

Annual Meeting Seminars Programmed by the AAAAI. Annual Meeting Seminars funded through an educational grant from Merck. fee required

3008 Medical Management of Eosinophilic Esophagitis in Adults Mark Holbreich, MD FAAAAI Javed Sheikh, MD FAAAAI Marriott South Tower, Level 3, Del Mar Upon completion of this session, participants should be able to: Show the appropriate use of diet in EoE management in adults; Demonstrate the different medications and become familiar with dose and delivery; Describe the pros and cons of esophegeal dilation in EoE.

3009 Mastocytosis Mimics: Cutting Through the Clutter Joseph H. Butterfield, MD FAAAAI Melody C. Carter, MD Marriott South Tower, Level 3, Miramar Upon completion of this session, participants should be able to: List the criteria for diagnosing systemic mastocytosis; Recognize the variety of mast cell activation disorders and the criteria needed for a true diagnosis of mast cell activation syndrome; Describe the differential diagnostic possibilities when faced with a patient with symptoms suggestive of systemic mastocytosis or mast cell activation syndrome.

3010 Optimizing the Allergist’s Expertise in Asthma Adherence Bruce G. Bender, PhD FAAAAI L. Keoki Williams, MD MPH FAAAAI Marriott South Tower, Level 1, Point Loma Upon completion of this session, participants should be able to: Discuss an appreciation for the prevalence and implications of suboptimal adherence in asthma; Develop clues which may suggest suboptimal adherence; Discuss strategies to facilitate optimal controller use in specific asthmatic patients.

3011 Is Immunotherapy Getting Safer? Updated Information on Various Forms of Immunotherapy and How to Improve Tolly Epstein, MD MS Michael S. Tankersley, MD FAAAAI Marriott South Tower, Level 1, Solana Upon completion of this session, participants should be able to: Summarize current evidence regarding the incidence of fatal reactions to SCIT; Critically assess new evidence characterizing risk factors associated with SCIT anaphylaxis that may be applied to optimize safety protocols; Discuss the necessity of the thirty minute waiting period after SCIT injections.

Rakesh Chandra, MD Raymond G. Slavin, MD MS FAAAAI Marriott South Tower, Level 1, Santa Rosa Upon completion of this session, participants should be able to: Utilize an evidence-based approach to the diagnosis and treatment of chronic rhinosinusitis.

James J. Anderson, MLT Peter J. Pityn, PhD Marriott South Tower, Level 3, Mission Hills

ticket required

Upon completion of this session, participants should be able to: Explore the human microbiome and allergic disease; Discuss the normal indoor microbiome and factors that cause alterations in the typical structure.

3012 Clinical Conundrums in Chronic Rhinosinusitis

Upon completion of this session, participants should be able to: Review novel testing for recurrent or unusual infections; Discuss genetic testing for primary immunodeficiency diseases; Discuss future testing for primary immunodeficiency.

Allied Health Session

Christina E. Ciaccio, MD FAAAAI Brett J. Green, PhD Marriott South Tower, Level 3, Cardiff

3013 Understanding How Allergic Responses End: The Allergy Resolvome Koichiro Asano, MD Ariel Munitz, PhD Marriott South Tower, Level 4, La Costa Upon completion of this session, participants should be able to: Identify factors involved in resolution of inflammation; Review lipid mediators’, IL-10 and endocannabinoids’ mechanism of action in the resolution of inflammation.

included in the Virtual Annual Meeting

55

SUNDAY, MARCH 2 3014 Inhibitory Receptors on Allergy Effector Cells: New Therapeutic Targets

3044 Tips on Training School Personnel about Food Allergies and Anaphylaxis

Bruce S. Bochner, MD FAAAAI Francesca Levi-Schaffer, PhD FAAAAI Marriott South Tower, Level 4, Catalina

Sonia C. Mancia, RN Humaira Robinson, BSN RN Marriott North Tower, Lobby Level, New York & Orlando

Upon completion of this session, participants should be able to: Discuss the mechanisms of three different inhibitory receptors pertinent for asthma; Describe efforts to therapeutically target these receptors.

3015 Parasites, Allergy and Asthma

Upon completion of this session, participants should be able to: Discuss tips on how to train school personnel to recognize and treat anaphylaxis; Review evidence regarding the content to include training and the efficacy of such training.

Plenary

Luisa Karla P. Arruda, MD PhD FAAAAI Thomas A.E. Platts-Mills, MD PhD FAAAAI Marriott South Tower, Level 4, Coronado

3101 Integrated Airways

Upon completion of this session, participants should be able to: Review outcomes of clinical trials conducted with parasites to treat patients with asthma or rhinitis; Discuss epidemiologic studies on parasites, allergy and asthma carried out in different areas of the world and with different populations; Discuss mechanisms by which parasite infection may influence immune responses underlying allergy and asthma and the role of parasite infections in total and specific IgE.

8:15 8:45

Allied Health Seminars 7:00 to 8:00 am Pre-registration and ticket required. Fee: $10. Sessions are limited to 30 people. Credit: 1.00 CME / 1.20 CE

3041 PFT Interpretation: Beyond the FVC Edward O. Corazalla, MS RPFT Marriott North Tower, Lobby Level, Rancho Santa Fe 1 & 2 Upon completion of this session, participants should be able to: Review the effect clinical status has on PFT testing; Develop the ability to interpret difficult spirometry tracings; Interpret PFTs and develop options to modify the asthma care plan.

9:15

Upon completion of this session, participants should be able to: Discuss the immunopathogenesis of barrier dysfunction in chronic rhinosinusitis; Describe the relationship between barrier dysfunction and the immunopathogenesis of asthma; Discuss how asthma endotypes are influencing the development of personalized asthma therapy.

Posters 7:00 am to 6:00 pm Convention Center, Ground Level, Exhibit Hall B Posters on display from 7:00 am to 6:00 pm. Authors present from 9:45 to 10:45 am. Credit: No CME / No CE Refer to pages 83 – 158 for abstracts and authors.

3042 Recurrent Infections: When is a “Little Cold” More Than a “Little Cold” Joseph L. Roberts, MD PhD Debra A. Sedlak, MSN CPNP Marriott North Tower, Lobby Level, Torrey Pines 1 & 2 Upon completion of this session, participants should be able to: Develop an appreciation of the multiple presentations of the patient with recurrent infections; Discuss the selection of appropriate testing to determine if the patient has or is evolving to a primary immunodeficiency diagnosis; Review the appropriate screening test for non-PIDD diagnosis (autoimmune, endocrine).

3043 Complementary and Alternative Medicine (CAM): What’s New and What We Need to Know: Taking a History and Providing Guidance on Patients’ Use of CAM in Allergy and Asthma Maureen George, PhD RN AE-C William S. Silvers, MD FAAAAI Marriott North Tower, Lobby Level, Atlanta & Chicago Upon completion of this session, participants should be able to: Discuss commonly used CAM for seasonal allergies and asthma; Describe the evidence for saline nasal irrigation, acupuncture, butterbur, honey and other CAM in a clinical case; Investigate online resources for reference, e.g. NCCAM (NIH National Center for Complementary and Alternative Medicine), Natural Medicines Comprehensive Database, etc.

8:15 to 9:45 am Convention Center, Ground Level, Exhibit Hall A Credit: 1.50 CME / 1.80 CE Moderator: Steve N. Georas, MD Host Defense, Inflammation and Remodeling in the Upper Airway Robert P. Schleimer, PhD FAAAAI Barrier Dysfunction in the Lower Airway Donna Davies, BSc PhD Asthma Endotypes: The Next Step Towards Personalized Asthma Care Sally E. Wenzel, MD FAAAAI

3201 3202 3203 3204 3205 3206 3207 3208 3209 3210 3211 3212 3213 3214

Annual Meeting Seminars

Bronchoprovocation and Asthma Comorbidities Biomarkers and Asthma Control I Atopic Disease Basic Science T Cell Mediated Immunity Asthma Epidemiology, Risk Factors and Public Health II Aerobiology II Food Allergy I Urticaria Pediatric Population Health Health Information Technology Chronic Rhinosinusitis and Polyps Rhinitis Mechanisms of Lymphocyte Function Role of Structural Cells in Mechanisms in Health and Disease

Programmed by the AAAAI. Annual Meeting Seminars funded through an educational grant from Merck.

56

Allied Health Session

ticket required

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SUNDAY, MARCH 2 Symposium

Symposium

3301 EAACI: Novel Developments in Asthma Exacerbations

3303 Update of the Allergic Contact Dermatitis Practice Parameter: What’s New in 2014?

10:45 11:05

11:25 11:45

10:45 am to 12:00 pm Convention Center, Upper Level, Ballroom 6A Credit: 1.25 CME / 1.50 CE Moderators: Cezmi A. Akdis, MD FAAAAI Nikolaos G. Papadopoulos, MD FAAAAI Molecular Mechanisms of Asthma Exacerbations Evangelos Andreakos, PhD Immune Response to Rhinoviruses and Their Link to Asthma Exacerbations Mubeccel Akdis, MD PhD Eicosanoids and Asthma Exacerbations Marek Sanak, MD Question & Answer

10:45

11:05

11:25 11:45

10:45 am to 12:00 pm Convention Center, Upper Level, Ballroom 6CF Credit: 1.25 CME / 1.50 CE Moderator: H. Henry Li, MD PhD Clinical Pearls and Clues in the Assessment of the Patient Referred for Evaluation of Contact Dermatitis and Patch Testing David I. Bernstein, MD FAAAAI What are the Most Common Chemical Sensitizers at Home and in the Workplace? Luz S. Fonacier, MD FAAAAI Metal Allergy and Implantable Devices Karin A. Pacheco, MD MSPH FAAAAI Question & Answer

Upon completion of this session, participants should be able to: List mechanisms underlying asthma exacerbations; Describe the interaction of respiratory viruses with epithelium, the immune system and how eicosanoids play a role in the pathogenesis of asthma exacerbations.

Upon completion of this session, participants should be able to: Identify key factors in clinical history and patch testing in suspected allergic contact dermatitis; Identify the most frequent contact sensitizers encountered at home and in the workplace; Discuss the relationship between metal hypersensitivity and prosthetic joint failure.

Symposium

Symposium

3302 Pathophysiology and Management of Urticaria and Angioedema

3304 Wheezing Episodes in Preschool Children: The Role of Bacterial Pathogens, Treatment of Acute Exacerbations and Potential for Asthma Prevention

10:45 11:05

11:25

11:45

10:45 am to 12:00 pm Convention Center, Upper Level, Ballroom 6B Credit: 1.25 CME / 1.50 CE Moderator: David R. Weldon, MD FAAAAI Pathophysiology of Chronic Urticaria Thomas B. Casale, MD FAAAAI Diagnostic Evaluation of Patients with Chronic Urticaria/ Angioedema: What Does the Evidence Tell Us? David M. Lang, MD FAAAAI Therapy Options for Patients with Anti-Histamine Resistant Chronic Urticaria Javed Sheikh, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Describe updates of the pathophysiology of chronic urticaria; Describe cost-effective and evidence-based diagnostic evaluation of patients with chronic urticaria/angioedema; Relate evidence supporting use of therapeutic interventions for patients with antihistamine-resistant urticaria/ angioedema.

Allied Health Session

ticket required

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10:45 11:05

11:25

11:45

10:45 am to 12:00 pm Convention Center, Upper Level, Ballroom 6DE Credit: 1.25 CME / 1.50 CE Moderator: Leonard B. Bacharier, MD FAAAAI Wheezing Episodes in Preschool Children: Beyond Viral Infections Daniel J. Jackson, MD Oral Corticosteroids as a Treatment of Acute Wheezing Episodes in Preschool Children: What is the Evidence for the Efficacy of This Treatment? Avraham Beigelman, MD MSCI The Utility of Oral Bacterial Extracts as a Prevention Modality for Wheezing Episodes and Asthma Fernando D. Martinez, MD Question & Answer

Upon completion of this session, participants should be able to: Discuss the current evidence of the role of bacterial pathogens in the pathogenesis of wheezing episodes in preschool children; Evaluate whether the current evidence supports the utility of oral corticosteroids as a treatment for acute wheezing episodes in preschool children; Discuss emerging concepts on the utility of immunostimulants for the prevention of wheezing episodes and potentially asthma.

included in the Virtual Annual Meeting

57

SUNDAY, MARCH 2 Symposium

Symposium

3305 Molecular Allergy: From Bench to Bedside

3307 The Emergence of Innate Lymphocyte Populations Driving Allergic Disease

10:45

11:05

11:25

11:45

10:45 am to 12:00 pm Convention Center, Upper Level, Room 11AB Credit: 1.25 CME / 1.50 CE Moderator: Robert G. Hamilton, PhD D.ABMLI FAAAAI Improved Diagnostics for Food Allergy: Higher Analytical Sensitivity and Better Risk Assessment Using Single Molecules Kirsten Beyer, MD Improved Diagnostics for Inhalant Allergy: Addressing Plant Related Crossreactivity and Multisensitizations with Single Molecules Joerg R. Kleine-Tebbe, MD FAAAAI Allergenic Molecules in Anaphylactic Reactions: Improved Differentiation and Analytical Sensitivity Markus W. Ollert, MD Question & Answer

Upon completion of this session, participants should be able to: Discuss the diagnostic value of food components and how they can lead to improved diagnostic answers and advice to the patient; Describe the diagnostic value of inhalant allergen components and how they can lead to improved diagnostic answers and advice to the multi- sensitized patient; Identify recently identified components from bee and wasp venom, latex and other protein allergens that facilitate definitive answers in cases of presumed sensitizations and enhance analytical sensitivity.

10:45 11:05 11:25

11:45

Upon completion of this session, participants should be able to: Discuss the various innate cell populations and their contributions to allergic inflammation and pathogenesis; Identify the role of lipid mediators in regulation of adaptive Th2 immunity; Identify the potential roles of innate lymphocytes in allergic disease.

Symposium 3308 Closing the Outcome Gap for Women with Asthma : A Tribute to Noreen M. Clark, PhD

Symposium 3306 The Relationship Between Allergies and Infections

10:45 11:05 11:25 11:45

10:45 am to 12:00 pm Convention Center, Room 14AB Credit: 1.25 CME / 1.50 CE Moderator: Dorothy S. Cheung, MD FAAAAI Basophils: Initiators of the Immune Response Caroline L. Sokol, MD PhD Mast Cells in the Immune Response Against Bacteria Soman N. Abraham, PhD Role of IgE in the Anti-Viral Immune Response Mitchell H. Grayson, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Discuss the ability of basophils to present antigen and start an immune response; Describe the data suggesting that the production of IgE is part of the antiviral immune response; Discuss how mast cells play a role in the clearance of bacterial and viral infections.

10:45 am to 12:00 pm Convention Center, Mezzanine Level, Room 15AB Credit: 1.25 CME / 1.50 CE Moderator: Larry Borish, MD FAAAAI Innate Properties of IL-5+ “Super-Effector” Th2 Cells Calman Prussin, MD FAAAAI Type 2 Innate Lymphoid Cell Activation by CysLTs Taylor A. Doherty, MD FAAAAI Innate Lymphoid Cells and Invariant Natural Killer T Cells in Asthma Dale T. Umetsu, MD PhD FAAAAI Question & Answer

10:45

11:05 11:25

11:45

10:45 am to 12:00 pm Convention Center, Mezzanine Level, Room 16AB Credit: 1.25 CME / 1.50 CE Moderator: Georgiana M. Sanders, MD MS FAAAAI Clinical, Social, and Cultural Factors in Asthma Management by Women and Potential Outcomes from Gender Focused Interventions Georgiana M. Sanders, MD MS FAAAAI Asthma Management in Women with Multiple Morbidities Mary Janevic, MPH PhD Special Challenges in Treatment and Self Management for Older Women with Asthma Alan P. Baptist, MD MPH FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Describe the range of treatment and management challenges and solutions particular to their female asthma patients; Recognize elements of education for female patients that are associated with reduced health care use and symptom burden.

Allied Health Symposium 3311 Update on Experience Performing Baked Egg and Baked Milk Food Challenges

11:45

10:45 am to 12:00 pm Marriott North Tower, Lobby Level, Marriott Hall Salons 1 & 2 Credit: 1.25 CME / 1.50 CE Moderator: Kim E. Mudd, RN MSN CCRP Teri Holbrook, RN CRNP Hemant P. Sharma, MD MHS FAAAAI Elisabeth S. Stieb, RN BSN AE-C Question & Answer

Upon completion of this session, participants should be able to: Identify which children can be considered for a food challenge to baked milk and baked egg; Describe the appropriate protocol to use in your practice to conduct a baked milk and baked egg food challenge; Discuss how children who pass a baked milk and baked egg food challenge can increase the foods in their diets.

58

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

SUNDAY, MARCH 2 Allied Health Workshop

Allied Health Oral Abstract Session

3312 Motivational Interviewing Strategies

3520 Allied Health Oral Abstract Luncheon

11:30

10:45 am to 12:00 pm Marriott North Tower, Lobby Level, Rancho Santa Fe 1 & 2 Credit: 1.25 CME / 1.50 CE Moderator: Michael S. Tankersley, MD FAAAAI Beth A. Allison, NP Question & Answer

Upon completion of this session, participants should be able to: Discuss the role of ambivalence in behavior change; Describe strategies for dealing with patient resistance; Review brief motivational interviewing strategies to incorporate into practice.

12:15

12:30

Allied Health Workshop 3313 Immunotherapy Guideline Update: Third Edition and USP 797 Compliance 10:45 am to 12:00 pm Marriott North Tower, Lobby Level, Torrey Pines 1 & 2 Credit: 1.25 CME / 1.50 CE Panelists Cheryl Koff Bernstein, RN BSN CCRC Michael R. Nelson, MD PhD FAAAAI

12:45

1:00 1:15

Upon completion of this session, participants should be able to: Discuss the requirements and importance of becoming compliant with USP chapter 797; Describe the compliance requirements for allergen extract preparation according to the USP chapter 797 and immunotherapy Practice Parameters Guidelines Third Edition Update; Identify practical approaches for implementation of the guidelines.

Upon completion of this session, participants should be able to discuss the diversity in care provided to the allergy and immunology patient population.

Interest Section Forum 3521 ADT: Hot Issues in Asthma

Allied Health Workshop 3314 Childhood Asthma and Obesity: What Do We Know? What Can We Do?

11:25

10:45 am to 12:00 pm Marriott North Tower, Lobby Level, Atlanta & Chicago Credit: 1.25 CME / 1.50 CE Moderator: Stephen J. McGeady, MD FAAAAI Anne E. Borgmeyer, MSN RN CPNP AE-C Carina Venter, PhD RD Question & Answer

12:30 12:35 1:05 1:15

Upon completion of this session, participants should be able to: Outline the relationship between asthma and obesity; Review current guidelines for the management of childhood obesity and asthma; Discuss barriers to adherence for obese children with asthma and their families.

3315 Team Approach to Providing Interdisciplinary Care of Atopic Dermatitis

11:15

1:45

2:15

Allied Health Workshop

12:15 to 1:30 pm Marriott North Tower, Lobby Level, San Diego Ballroom Salon C Pre-registration and ticket required. Fee: $40. Box lunch included. Credit: 1.25 CME / 1.50 CE Moderator: Debra A. Sedlak, MSN CPNP Clinical Efficacy Of Subcutaneous and Sublingual Immunotherapy In Asthma and Rhinitis Children Sensitized To House Dust Mite Min-Ju Kim A Patient-Reported Symptom-Based Predictor Of Objective Sinus Inflammation Alcina K. Lidder, BA Healthcare Providers’ Perception vs. Reality In Patient Concerns About Starting Subcutaneous Immunoglobulin Carla M. Duff, CPNP MSN Anaphylaxis During Obstetric Surgery In Latex Allergic Patients Nana Jinjolava, MD The Impact Of Legislation On Illinois School Nurses Christine Szychlinski, APN CPNP

12:30 to 2:30 pm Convention Center, Upper Level, Room 5AB Pre-registration and ticket required. No fee. Box lunch included. Bring your mobile device to participate. Credit: 1.25 CME / 1.50 CE Moderator: Timothy J. Craig, DO FAAAAI Lunch Business Meeting Timothy J. Craig, DO FAAAAI Question & Answer Why are Microbiomes Important in Asthma? Homer A. Boushey, MD FAAAAI Update on Newer Approved Therapies and New Uses of Old Drugs for Asthma William W. Busse, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Discuss the importance of microbiomes in asthma; Discuss the introduction of new therapies into the present care of asthma; Describe how biologicals can affect asthma care.

10:45 am to 12:00 pm Marriott North Tower, Lobby Level, New York & Orlando Credit: 1.25 CME / 1.50 CE Moderator: Jennifer S. LeBovidge, PhD Karol G. Timmons, RN MS CPNP Wendy Elverson, RD LDN Question & Answer

Upon completion of this session, participants should be able to: Describe the formation of a multidisciplinary team to care for children with atopic dermatitis; Discuss the role of a psychologist/mental health professional in an interdisciplinary clinic for children with atopic dermatitis; Describe the role of a nutritionist in an interdisciplinary clinic to optimize nutritional care for patients with atopic dermatitis.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

59

SUNDAY, MARCH 2 Interest Section Forum

Interest Section Forum

3522 BCI: Cutting-Edge Research from Members of the Basic and Clinical Immunology Interest Section

3524 FADDA: Practice Parameter Updates on Allergic Skin Diseases

12:30 12:35 1:05 1:15

1:45

2:15

12:30 to 2:30 pm Convention Center, Upper Level, Room 11AB Pre-registration and ticket required. No fee. Box lunch included. Credit: 1.25 CME / 1.50 CE Moderator: Francisco A. Bonilla, MD PhD FAAAAI Lunch Business Meeting Francisco A. Bonilla, MD PhD FAAAAI Question & Answer Nanotechnology Meets Allergy: The Yin and Yang of Nanoscale Toxicity and Therapy James R. Baker, Jr., MD FAAAAI Genome Safari: Navigating the Nucleotides to Find the Origins of Asthma Kathleen C. Barnes, PhD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Discuss nanotechnology applications in medicine generally; Identify nanotechnology applications specific to allergy and immunology; Describe the most recent advances in genomic approaches to understanding the origins of asthma and allergy.

12:30 12:35 1:05 1:15

1:45

2:15

12:30 to 2:30 pm Convention Center, Upper Level, Ballroom 6A Pre-registration and ticket required. No fee. Box lunch included. Bring your mobile device to participate. Credit: 1.25 CME / 1.50 CE Moderator: David A. Khan, MD FAAAAI Lunch Business Meeting David A. Khan, MD FAAAAI Question & Answer Atopic Dermatitis: Updates on Evaluation and Management from the Practice Parameter Lynda C. Schneider, MD FAAAAI Chronic Urticaria: Updates on Diagnostic Testing and Therapy from the Practice Parameter Jonathan A. Bernstein, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Describe recent updates to the practice parameter on atopic dermatitis focusing on evaluation and management of atopic dermatitis; Discuss recent updates to the practice parameter on urticaria focusing on evaluation and management of chronic urticaria.

Interest Section Forum 3523 EORD: Metals, Cements and Glues: Assessing the Exposure: Diagnosing the Disease

12:30 12:35 1:05 1:15

1:45

2:15

12:30 to 2:30 pm Convention Center, Mezzanine Level, Room 14AB Pre-registration and ticket required. No fee. Box lunch included. Credit: 1.25 CME / 1.50 CE Moderator: Jeffrey G. Demain, MD FAAAAI Lunch Business Meeting Karin A. Pacheco, MD MSPH FAAAAI Question & Answer Metals: Source Exposures, Disease Outcomes, and Making the Association Between the Two James S. Taylor, MD Cements and Glues: Common and Overlooked Causes of Allergic Disease Karin A. Pacheco, MD MSPH FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Recognize common occupational and procedure-related exposures to metals, cements and glues; Identify which of these to suspect in adverse reactions in the workplace or the surgical suite; Describe how best to establish the diagnosis of sensitization to these agents.

Interest Section Forum 3525 HEDQ: Bringing Added Value to Accountable Care Organizations (ACOs) Through Asthma Population Management

12:30 12:35 12:40 1:05 1:15

1:45

2:15

12:30 to 2:30 pm Convention Center, Mezzanine Level, Room 15AB Pre-registration and ticket required. No fee. Box lunch included. Bring your mobile device to participate. Credit: 1.25 CME / 1.50 CE Moderators: Bruce G. Bender, PhD FAAAAI Giselle Mosnaim, MD MS FAAAAI Lunch Tribute to Dr. Noreen Clark Business Meeting Giselle Mosnaim, MD MS FAAAAI Question & Answer Asthma Population Management (Part 1): Identifying Persistent Asthma, Defining High Risk Asthma, and Measuring Quality of Asthma Care Michael Schatz, MD MS FAAAAI Asthma Population Management (Part 2): Strategies for Improving Clinical Outcomes and Improving Quality of Care William W. Crawford, MD Robert J. Becker, MD, Memorial Lectureship Recipient Question & Answer

Upon completion of this session, participants should be able to: Define the administrative data elements necessary for effective management of large populations of asthma patients; Describe the barriers to reducing emerengy room asthma visits at the level of a large population of asthma patients; Identify strategies for improving performance on publicly reported asthma quality of care measures.

60

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

SUNDAY, MARCH 2 Interest Section Forum

Allied Health Course

3526 IRSOC: Make Sublingual Immunotherapy One of Your Tools in Your Practice

3551 The International Network for Diet and Nutrition in Allergy (INDANA): Add Nutrition Management to Your Practice Toolkit

12:30 12:35 1:05 1:15

1:45

2:15

12:30 to 2:30 pm Convention Center, Upper Level, Ballroom 6B Pre-registration and ticket required. No fee. Box lunch included. Credit: 1.25 CME / 1.50 CE Moderator: Désirée E.S. Larenas Linnemann, MD FAAAAI Lunch Business Meeting Désirée E.S. Larenas Linnemann, MD FAAAAI Question & Answer How to Select and Administer Grass SLIT Among the Patients of Your Practice Michael S. Blaiss, MD FAAAAI How to Select and Administer House Dust Mite SLIT Among the Patients of Your Practice in the Future Giovanni Passalacqua, MD Question & Answer

Upon completion of this session, participants should be able to: Comment on which patients would make good and which would make bad candidates for SLIT; Discuss safety issues concerning SLIT with grass pollen extracts, especially focused on practical similarities and differences in Europe and U.S.; Give an overview of innovative formula of house dust mite SLIT, as are the tablets and use of adjuvants and argue how molecular diagnosis might have implications for immunotherapy.

3527 MAAI: Novel Mechanisms in Turning Inflammation On and Off

1:10 1:15 1:45 2:15

1:10 1:45 2:20 2:55 3:10 3:45 4:20

Upon completion of this session, participants should be able to: Recognize how to take a dietary history and link symptoms to food ingredients; Identify the implications (social, emotional, financial and nutritional) of allergen elimination diets and how to minimize the impact on patients and families; Describe the nutritional implications of various avoidance diets and how to advise patients on substitutes to meet nutrient needs.

Interest Section Forum

12:30 12:35 12:50

12:30

12:30 to 5:00 pm Marriott North Tower, Lobby Level, Marriott Hall Salons 1 & 2 Pre-registration and ticket required. Fee: $30. Credit: 4.25 CME / 5.10 CE Moderator: Marion E. Groetch, MS RD Diet History: Making the Right Connections Isabel J. Skypala, PhD What’s in a Label? Berber Vlieg-Boerstra, PhD RD Food Triggers: The Degree of Avoidance Marion E. Groetch, MS RD A Day in the Life Jamie L. Kabourek, MS RD Break Oops...Frequently Made Mistakes in Nutrition and Allergy G. Lynn Christie, MS RD Prevention and Weaning Carina Venter, PhD RD What is a Healthy Diet Anyway? Kathryn E. Grimshaw, PhD RD

12:30 to 2:30 pm Convention Center, Mezzanine Level, Room 16AB Pre-registration and ticket required. No fee. Box lunch included. Credit: 1.25 CME / 1.50 CE Moderator: Mitchell H. Grayson, MD FAAAAI Lunch Tribute to Dr. Redwan Moqbel Business Meeting Mitchell H. Grayson, MD FAAAAI Question & Answer Epithelial Cell Apoptosis Protects Against Inflammation Larry Borish, MD FAAAAI Eicosanoid Storm: The Role of the Inflammasome Karsten Gronert, PhD Question & Answer

Upon completion of this session, participants should be able to: Describe how epithelial cells control inflammation through ingestion of apoptotic cells; Describe how the inflammasome contributes to inflammation through the rapid release of eicosanoids.

Oral Abstract 3601 Biomarkers

2:45

3:00

3:15

3:30

3:45

2:45 to 4:00 pm Convention Center, Upper Level, Ballroom 6A Credit: 1.25 CME / 1.50 CE Moderators: Faoud T. Ishmael, MD PhD FAAAAI Leonard B. Bacharier, MD FAAAAI Socio-Demographic and Environmental Correlates Of Exhaled Nitric Oxide Levels Lakiea S. Wright, MD MAT Relationships Between The New Biomarkers Induced By Interleukin-13 and Bronchial Hyperresponsiveness In Asthmatic Children: Periostin and Squamous Cell Carcinoma-Related Antigens Heysung Baek, MD PhD Exhaled Nitric Oxide Performance Compared To Methacholine Challenge In Asthma Andrew Nickels, MD Serum Interleukin 13 (IL-13) and Surfactant Protein D (SP-D) Expression Is Differentially Associated With Disease Status In Pediatric Asthma Patients Vasiliki Gemou-Engesaeth, MD PhD Correlation Of Exhaled Breath Temperature With Age In Chronic Respiratory Diseases Radoslaw Gawlik, MD

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

61

SUNDAY, MARCH 2 Oral Abstract

Oral Abstract

3602 Immune Mechanisms in Atopy

3604 Drug Allergy

2:45

3:00

3:15

3:30

3:45

2:45 to 4:00 pm Convention Center, Upper Level, Room 1AB Credit: 1.25 CME / 1.50 CE Moderators: Antonella Cianferoni, MD PhD Hans C. Oettgen, MD PhD FAAAAI Peripherally Induced Foxp3+ Regulatory T Cells Mediates The Immunomodulatory Effect Of Intravenous Immunoglobulin In An Experimental Model Of Allergic Airway Disease Amir Hossein Massoud, PhD Differential DNA Methylation In Mothers Increases The Prevalence Of Atopic Dermatitis In Their Offspring Pia J. Hauk, MD Hypereosinophilia In Children and Adults: A Retrospective Comparison Kelli Williams, MD MPH Interleukin 35 Modulates TSLP, IL-25 and IL-33 Primed Dendritic Cells and Inhibits Naive T Cell Differentiation and Grass PollenSpecific T Cell Proliferation Natalia C. Couto-Francisco Fc-Gamma-Receptor-IIb Is Required For The Immunomodulatory Actions Of Intravenous Immune Globulin In An Antigen-Driven Murine Model Of Allergic Airways Disease Gabriel N. Kaufman, MSc

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

2:45 3:00

3:15

3:30

3:45

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Oral Abstract 3605 Oral Immunotherapy for Food Allergy

Oral Abstract 3603 I. Leonard Bernstein Session on Occupational Allergic Diseases

2:45

3:00

3:15 3:30

3:45

2:45 to 4:00 pm Convention Center, Upper Level, Room 11AB Credit: 1.25 CME / 1.50 CE Moderator: Jonathan A. Bernstein, MD FAAAAI Endotoxin In Size-Specific Airborne Particles Induces Differential Nitrative Stress In Human Bronchoepithelial Cells Umesh Singh High Rates Of Sensitization To Selected Metals and Bone Cement In Joint Replacement Failure Patients and Preoperative Evaluations Karin A. Pacheco, MD MSPH FAAAAI Component Resolved Diagnosis In Baker’s Asthma Cristina Gómez-Casado Endotoxin Exposure May Protect Against The Development Of Rhinoconjunctivitis and Respiratory Symptoms In Non-Atopic Individuals With Occupational Exposure To Mice Sharon K. Ahluwalia, MD Sensitization To Occupational Allergens and Allergic Diseases In Workers Of 5 Havana Bakeries Mirta Alvarez, MD

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

62

2:45 to 4:00 pm Convention Center, Upper Level, Ballroom 6CF Credit: 1.25 CME / 1.50 CE Moderators: Mariana C. Castells, MD PhD FAAAAI Miguel A. Park, MD Safety Of Propofol Use In Patients With Food Allergies Harshna Mehta, MD Risk Stratification Protocol For Carboplatin and Oxaliplatin Hypersensitivity Reactions With Repeat Skin Testing Improves Care Alberta L. Wang, MD Added Value Of Skin Testing In Hypersensitivity Reactions To Taxanes Matthieu Picard, MD Risk Stratification For Paclitaxel-Induced Hypersensitivity Reactions Improves Quality Of Care Timothy P. Lax, MD Healthcare Utilization and Serious Infection Prevalence Associated With Penicillin “Allergy” In Hospitalized Patients: A Cohort Study Eric M. Macy, MD FAAAAI

2:45

3:00

3:15

3:30

3:45

2:45 to 4:00 pm Convention Center, Upper Level, Ballroom 6B Credit: 1.25 CME / 1.50 CE Moderators: J. Andrew Bird, MD FAAAAI Amy M. Scurlock, MD Length Of Avoidance Period Following Peanut Oral Immunotherapy Influences Effector Cell Suppression and Clinical Outcomes Michael D. Kulis Jr., PhD Basophil Hyporesponsiveness To Peanut Following Immunotherapy May Be Transient and Correlates With Clinical Response Mark Gorelik, MD Safety Of Pediatric Peanut Oral Immunotherapy Is Complicated By High Adverse Event Rates Yamini Virkud, MD MA Course and Outcome Of Patients With Asthma During Oral Immunotherapy To Cow’s Milk Protein Arnon Elizur, MD B-Fahf-2 Pretreatment Reduces OIT Adverse Reactions and Improves Outcomes In a Murine Model Of Multiple Nut Allergy Xiu-Min Li, MD

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

SUNDAY, MARCH 2 Oral Abstract

Oral Abstract

3606 Adherence

3608 Mechanisms of Eosinophil-Driven Disease

2:45

3:00

3:15

3:30

3:45

2:45 to 4:00 pm Convention Center, Upper Level, Room 2 Credit: 1.25 CME / 1.50 CE Moderators: Eugene M. Choo, MD FAAAAI Sujani Kakumanu, MD Adherence Documentation During Asthma Encounters At a Pediatric Tertiary Care Referral Center Kara J. Wada, MD High-Risk Asthma Multidisciplinary Care Clinic Adherence Linked To Asthma Control Test (ACT) Score Improvement Bradley A. Locke, DO Understanding Asthma Medical Nonadherence In Adult and Pediatric Populations Joyce Xiang Wu Lee, MD Improved Education and Self-Management In Children and Adolescents With Asthma Using a Personalized Smartphone Application David R. Stukus, MD FAAAAI Misuse Of Medical Devices Among Patients In a Tertiary Care Allergy/Immunology Practice Rana S. Bonds, MD FAAAAI

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

2:45

3:00

3:15

3:30 3:45

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Featured Poster Session and Reception 4:00 to 6:00 pm Convention Center, Upper Level, Ballroom 6 Lobby All Annnual Meeting delegates and their guests are invited to attend this event. No fee and no pre-registration required. Credit: No CME / No CE Featured Posters highlight the highest quality abstracts submitted for presentation at the Annual Meeting. During the Featured Poster Session and Reception on Sunday evening, authors will be present with their posters to discuss their research. Take this opportunity to talk with these authors and network with other meeting delegates.

Oral Abstract 3607 Mechanisms of Immunotherapy

2:45

3:00

3:15

3:30

3:45

2:45 to 4:00 pm Convention Center, Upper Level, Ballroom 6DE Credit: 1.25 CME / 1.50 CE Moderator: Mark Larché, PhD B Cells and Plasma Cells Populations Suffer Changes Along The Time After Dermatophagoides Pteronyssinus Specific Immunotherapy Enrique Gómez, PhD A Subset Of Novel Timothy Grass Antigens Is Associated With Marked Th1/Th2 Shifts Following Specific Immunotherapy Veronique M. Schulten Interleukin IL-27+ Dendritic Cells Modulate Ex-Vivo Th2 Responses In a Pdl-1-Dependent Manner and Increase In-Vivo Following Grass Pollen Immunotherapy Tomokazu Matsuoka Local ‘Protective’ IgG4 Antibodies In Nasal Fluid Are Elevated Following Grass Pollen Immunotherapy Jinjin Zhang Grass Pollen Immunotherapy: Impaired Allergen-Induced Nasal and Cutaneous Responses Correlate With Overall Seasonal Symptom Scores and Are Associated With Suppressed Local Th2 Cytokines In Nasal Fluid Guy W. Scadding, MD

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Allied Health Session

ticket required

fee required

2:45 to 4:00 pm Convention Center, Upper Level, Room 7AB Credit: 1.25 CME / 1.50 CE Moderators: Paige Lacy, PhD FAAAAI Hans-Uwe Simon, MD PhD FAAAAI IL-4 and IL-13 Differentially Regulate TLR-Induced EosinophilBasophil Differentiation Of Cord Blood CD34+ Progenitor Cells Pia Reece, PhD Basophils Act As a Cellular Switch to Drive Eosinophilic Inflammation after IgE Activation Laurence E. Cheng, MD PhD The SNARE VAMP-7 Contributes To Eosinophil Degranulation, In Vivo Paige Lacy, PhD FAAAAI Microbiota Regulates Eosinophils In The Small Intestine Rodrigo Jimenez-Saiz, PhD The Airway Mucins Muc5b and Muc4 Are Endogenous Ligands For Siglec-F and Induce Mouse Eosinophil Death Takumi Kiwamoto, MD PhD

3801 3802 3803 3804 3805 3806 3807

Best of ADT Advances in Primary Immunodeficiencies Best of EORD Best of FADDA Best of HEDQ Chronic Rhinosinusitis and Polyps The Redwan Moqbel Memorial MAAI Featured Poster Session 3811 Allied Health Featured Poster Second Annual ARTrust™ 5K Run/Walk: Light Up the Night 5:30 pm Embarcadero This event is open to everyone: serious runners, casual runners, walkers, families and the general public. Registration required. See page 13 for more information. Sponsored by Teva Respiratory.

included in the Virtual Annual Meeting

63

MONDAY, MARCH 3 Seminars 7:00 to 8:00 am Pre-registration and ticket required. Fee: $40. Continental breakfast included. Sessions and meals are limited to 30 people. Credit: 1.00 CME / 1.20 CE

4001 Asthma and the Older Adult Alan P. Baptist, MD MPH FAAAAI Paula L. Busse, MD FAAAAI Marriott South Tower, Level 3, Marina Ballroom Salon D Upon completion of this session, participants should be able to: Compare how asthma symptoms and spirometry may differ in older adults compared to younger populations; Identify unique factors associated with poor asthma control and quality of life in older adults; Discuss the optimal pharmacologic and non-pharmacologic management strategies for older adults with asthma.

4002 Use of Biomarkers in Severe Asthma Jonathan Corren, MD Faoud T. Ishmael, MD PhD FAAAAI Marriott South Tower, Level 3, Marina Ballroom Salon E Upon completion of this session, participants should be able to: Review and understand specific markers (blood and sputum eosinophils, FeNO, periostin, urine leukotrienes, EBT); Describe the relationship of these markers to specific asthma phenotypes and endotypes; Describe the use of these markers as predictors of efficacies of specific therapies.

4003 Evaluation of Autoinflammatory Disorders in Children Ronit Herzog, MD FAAAAI Lu Yao, MD Marriott South Tower, Level 3, Marina Ballroom Salon F Upon completion of this session, participants should be able to: Discuss the clinical and laboratory presentation of children with auto-inflammatory disorder; Describe the pathophysiology of auto-inflammatory disorder in children; Discuss the workup and management of children with suspected auto-inflammatory disorder.

4004 Selection and Implementation of an Electronic Medical Record David J. Shulan, MD FAAAAI Richard L. Wasserman, MD PhD FAAAAI Marriott South Tower, Level 3, Marina Ballroom Salon G Upon completion of this session, participants should be able to: Discuss why one would choose an EHR; Describe how to pick an EHR; Identify the needed procedures in implementing an EHR.

4005 The Spectrum of Presentations in Patients with Auto-Immune Lymphoproliferative Syndrome (ALPS) Jack J.H. Bleesing, MD PhD V. Koneti U. Rao, MD Marriott South Tower, Level 3, Balboa Upon completion of this session, participants should be able to: Discuss common findings in patients with ALPS; Review current laboratory testing for the disease; Discuss treatment options for ALPS.

4006 How to Get Your K Award Applications by a Mock Study Section

4007 Occupational Disease: New Agents, New Diseases, Prevention and Epidemiology Leslie C. Grammer, MD FAAAAI Santiago Quirce, MD PhD Marriott South Tower, Level 3, Cardiff Upon completion of this session, participants should be able to: Discuss new and updated knowledge in the areas discussed; Describe updated strategies for diagnosis and treatment of occupational diseases.

4008 Diagnosing an Allergy to Galactose Alpha 1,3 Galactose Scott P. Commins, MD PhD Maya R. Jerath, MD PhD Marriott South Tower, Level 3, Del Mar Upon completion of this session, participants should be able to: Describe the clinical presentation of alpha gal food allergy; Discuss how to diagnose and manage alpha gal food allergy.

4009 Non-IgE-Mediated Food Allergies Jean-Christoph Caubet, MD Anna H. Nowak-Wegrzyn, MD FAAAAI Marriott South Tower, Level 3, Miramar Upon completion of this session, participants should be able to: Discuss a variety of patient cases posing diagnostic dilemmas in non-IgE food allergy; Describe the utility of feeding history, skin prick, serum specific IgE testing and oral food challenge in diagnosing complex patients with possible GI food allergies.

4010 Outcomes and Quality Measures in Allergy Practice and Research Chitra Dinakar, MD FAAAAI Kaiser G. Lim, MD FAAAAI Marriott South Tower, Level 1, Point Loma Upon completion of this session, participants should be able to: Describe the most appropriate outcomes measures for assessment of quality practice in asthma and other allergic diseases; Discuss how to design an outcomes study for asthma.

4011 Proactive Management of Food Allergies in Schools Alton Lee Melton, MD Michael C. Young, MD FAAAAI Marriott South Tower, Level 1, Solana Upon completion of this session, participants should be able to: Identify activities and situations in the school setting that place allergic students at risk for accidental food allergen exposures; Discuss recommendations for schools and parents regarding best practices for treating reactions that do occur and proactively reducing the risk for accidental food allergen exposures.

4012 New Aspects of the Involvement of B and T Cells in the Mechanisms of Immunotherapy Mubeccel Akdis, MD PhD Mark Larche, PhD Marriott South Tower, Level 1, Santa Rosa Upon completion of this session, participants should be able to: Review new data of regulatory T cell involvement in the immunologic reactions documented after immunotherapy; Review new data of regulatory B cell involvement in the immunologic reactions documented after immunotherapy; Discuss the interactions between both these systems.

Nora A. Barrett, MD FAAAAI Lawrence J. Prograis, MD Joshua A. Boyce, MD FAAAAI Marriott South Tower, Level 3, Mission Hills

Annual Meeting Seminars

Upon completion of this session, participants should be able to: Describe the peer review process for K award applications; Describe common strengths and weaknesses in K award applications as identified by reviewers; Apply knowledge of common review concerns to the preparation of a competitive K award application.

64

Allied Health Session

Programmed by the AAAAI. Annual Meeting Seminars funded through an educational grant from Merck.

ticket required

fee required

included in the Virtual Annual Meeting

MONDAY, MARCH 3 4013 Chronic Rhinosinusitis Subtypes and Treatment Implications Amber U. Luong, MD PhD Rodney J. Schlosser, MD Marriott South Tower, Level 4, La Costa Upon completion of this session, participants should be able to: Describe the classification of sinusitis; Describe the clinical subtypes of chronic rhinosinusitis; Explain the different non-surgical treatment options for the different chronic rhinosinusitis subtypes.

4014 How Do Antigens Become Allergens?

Plenary 4101 Drug Allergy in the 21st Century

8:15 8:45

Angela Haczku, MD PhD FAAAAI Anne Sperling, PhD Marriott South Tower, Level 4, Catalina

9:15

Upon completion of this session, participants should be able to: Describe how the immune system recognizes innocuous allergens; Discuss dendritic cells, important sentinel cells in allergy; Identify the development of therapeutic agents that could fine tune the dendritic cell response.

4015 Th17 Cells, Neutrophils and Severe Asthma Dawn C. Newcomb Baker, PhD R. Stokes Peebles, Jr., MD FAAAAI Marriott South Tower, Level 4, Coronado

Upon completion of this session, participants should be able to: Discuss the genetic basis for selected drug reactions; Recognize and interpret erythematous drug eruptions; Develop expertise in the management of hypersensitivity reactions to chemotherapy, monoclonals, new biologicals and antibiotics.

Posters 7:00 am to 6:00 pm Convention Center, Ground Level, Exhibit Hall B Posters on display from 7:00 am to 6:00 pm. Authors present from 9:45 to 10:45 am. Credit: No CME / No CE Refer to pages 83 – 158 for abstracts and authors.

Upon completion of this session, participants should be able to: Describe the role of STAT signaling in Th17 cell development and cytokine expression; Define the role of gender in Th17 cell differentiation and cytokine expression in patients with severe asthma; Discuss the role of IL-17A on structural cells in the airway.

Allied Health Course 4051 Primer on Primary Immune Deficiency (PIDD)

8:00 8:45 9:30 10:15 10:30 11:15 12:00 12:30

1:30

8:15 to 9:45 am Convention Center, Ground Level, Exhibit Hall A Credit: 1.50 CME / 1.80 CE Moderator: David A. Khan, MD FAAAAI HLA and Drug Hypersensitivity David A. Ostrov, PhD Exanthematous Drug Eruptions Werner J. Pichler, MD New Challenges and Outcomes for Drug Desensitization Mariana C. Castells, MD PhD FAAAAI

8:00 am to 2:15 pm Marriott North Tower, Lobby Level, Marriott Hall Salon 1 Pre-registration and ticket required. Fee: $85. Box lunch included. Credit: 5.50 CME / 6.60 CE Moderator: Debra A. Sedlak, MSN CPNP Overview of PIDD: Disease Characteristics and Presentation M. Elizabeth M. Younger, CRNP PhD Basics of Diagnostic Testing William R. Blouin, ARNP Non-Immune Replacement Therapies Kristin Epland, NP Break Immune Replacement: Is There a Right Way? Debra A. Sedlak, MSN CPNP Transplantation in PIDD M. Louise Markert, MD PhD FAAAAI Lunch Break Panel Discussion Moderator: M. Elizabeth M. Younger, CRNP PhD Panelists: M. Elizabeth M. Younger, CRNP PhD William R. Blouin, ARNP Kristin Epland, NP Debra A. Sedlak, MSN CPNP M. Louise Markert, MD PhD FAAAAI Hands-On Instruction: SCIG Carla M. Duff, CPNP MSN Kristin Epland, NP

4201 4202 4203 4204 4205 4206 4207 4208 4209 4210 4211

Epidemiology: Asthma Control Biomarkers and Asthma Control II IVIG and Other Therapeutics Autoinflammatory Disorders Airborne Allergen Exposures Infections, Asthma and Allergies Immune Mediated Skin Diseases Food Allergy II Health Care Delivery Allergen Extracts and Immunotherapy Outcome Measures and Challenge Testing with Immunotherapy 4212 Mechanistic Insight into Pollens and Other Antigens

Upon completion of this session, participants should be able to: Identify and develop understanding of the multiple presentations of PIDD; Describe the various laboratory tests and appropriate application of these tests in the evaluation for PIDD; Develop an understanding of the treatments utilized in the management and treatment of PIDD.

Allied Health Session

ticket required

fee required

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65

MONDAY, MARCH 3 Symposium

Symposium

4301 American Lung Association Clinical Trials Network: Recent Advances

4304 How Close are We to Preventing Asthma by Vaccination?

10:45 11:05

11:25 11:45

10:45 am to 12:00 pm Convention Center, Upper Level, Ballroom 6B Credit: 1.25 CME / 1.50 CE Moderator: Stephen P. Peters, MD PhD FAAAAI Validation Studies of Asthma Outcomes for Clinical Research Speaker to be announced. Pharmacogenomic Studies of Asthma from the ALA ACRC Network John Lima, MD SOYA: Effect of Soy Isoflavones on Asthma Lewis J. Smith, MD Question & Answer

Upon completion of this session, participants should be able to: List newly defined asthma outcome measures; Describe the effect of new therapeutic options in asthma; Discuss new information on pharmacogenomics in asthma.

Symposium 4302 Primary Immunodeficiency at the Molecular Level: The Wave of the Future

10:45 11:05 11:25 11:45

10:45 am to 12:00 pm Convention Center, Upper Level, Ballroom 6CF Credit: 1.25 CME / 1.50 CE Moderator: Elena E. Perez, MD PhD FAAAAI Update on Newborn Screening for PID Jennifer M. Puck, MD New Immunodeficiencies Defined by Genomic Methods Janet S. Chou, MD Gene Therapy for PID: Quo Vadis? Fabio Candotti, MD Question & Answer

Upon completion of this session, participants should be able to: Discuss what progress has been made in the diagnosis of immunodeficiency at birth via newborn screening; Describe how genomic analysis is leading to an explosion in the discovery of new forms of immunodeficiency; Identify what advances are being made in gene therapy for immunodeficiency.

11:05 11:25 11:45

Upon completion of this session, participants should be able to: Define the data that link severe lower respiratory tract infection with rhinovirus and respiratory syncytial virus in infancy and the subsequent development of childhood asthma; Describe the current state of vaccine development for respiratory syncytial virus; Describe the current state of vaccine development for rhinovirus.

Symposium 4305 B Cell and Antibody Biology in Upper and Lower Airways

10:45

11:05 11:25 11:45

10:45 am to 12:00 pm Convention Center, Mezzanine Level, Room 14AB Credit: 1.25 CME / 1.50 CE Moderator: Patricia A. Takach, MD FAAAAI Epidemiology and Burden of Antibody Deficiency in Chronic Rhinosinusitis Anju T. Peters, MD FAAAAI B Cell Responses in Chronic Rhinosinusitis Kathryn E. Hulse, PhD Regulation of B Cell Activation and Antibody Production Mubeccel Akdis, MD PhD Question & Answer

Upon completion of this session, participants should be able to: Describe the epidemiology of antibody deficiency in chronic rhinosinusitis; Discuss the role of B cells in chronic rhinosinusitis; Identify the role of IgA in mucosal immunity in allergic diseases.

Symposium

Symposium

4303 Treatment Alternatives for Refractory Severe Asthma

4306 Immunosenescence: Implications of an Aging Immune System

10:45

11:05 11:25 11:45

10:45 am to 12:00 pm Convention Center, Upper Level, Ballroom 6DE Credit: 1.25 CME / 1.50 CE Moderator: Paula L. Busse, MD FAAAAI The Role of Anti-Cholinergics, Vitamin D Replacement and Fine Particle ICS Reynold A. Panettieri, MD The Role of Bronchial Thermoplasty Monica Kraft, MD Novel Approaches to Steroid Resistance Stanley J. Szefler, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Describe the risks and benefits of bronchial thermoplasty in severe asthma; Outline novel approaches to therapy of steroid resistant asthma; Discuss the evidence supporting the use of vitamin D replacement, anti-cholinergics and small particle inhaled corticosteroids.

66

10:45

10:45 am to 12:00 pm Convention Center, Upper Level, Room 11AB Credit: 1.25 CME / 1.50 CE Moderator: R. Stokes Peebles, Jr., MD FAAAAI The Role of Rhinovirus and RSV in Asthma Incepton Tina V. Hartert, MD MPH The Current State of Rhinovirus Vaccine Development Sebastian L. Johnston, MD PhD The Current State of RSV Vaccine Development Barney S. Graham, MD PhD Question & Answer

10:45 11:05 11:25 11:45

10:45 am to 12:00 pm Convention Center, Mezzanine Level, Room 15AB Credit: 1.25 CME / 1.50 CE Moderator: Sharmilee M. Nyenhuis, MD FAAAAI Effects of Aging on Immune Function Jorg Goronzy, MD PhD Vaccine Responses in the Elderly John M. Kelso, MD FAAAAI Effect of Aging on Asthma and Allergic Diseases Sameer K. Mathur, MD PhD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Describe changes in immune function with aging; Describe changes in vaccine response and current recommendations for vaccination in the elderly; Discuss the effect of aging on allergic diseases.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

MONDAY, MARCH 3 Symposium

Oral Abstract

4307 Wanted: Eosinophils, Dead or Alive? Eosinophil Cell Death Subroutines and Implications for Eosinophil-Targeted Therapy

4602 Bone Marrow Transplantation in Primary Immunodeficiencies

10:45

11:05

11:25 11:45

10:45 am to 12:00 pm Convention Center, Mezzanine Level, Room 16AB Credit: 1.25 CME / 1.50 CE Moderator: Gerald J. Gleich, MD FAAAAI Eosinophil Extracellular DNA Trap Cell Death (ETosis) Mediates Lytic Release of Free Secretion-Competent Eosinophil Granules Lisa A. Spencer, PhD FAAAAI Siglec-8 Engagement Induces Apoptotic or Lytic Eosinophil Cell Death, Depending on Cell Activation Status Nives Zimmermann, MD FAAAAI Targeting Eosinophils in Disease Parameswaran K. Nair, MD PhD FRCP Question & Answer

Upon completion of this session, participants should be able to: Identify cell death subroutines; Discuss consequences of eosinophils’ dying by different subroutines; Discuss consequences of cell death subroutines on efficacy and safety of eosinophil-targeting agents.

AAAAI Business Meeting 12:30 to 1:30 pm Convention Center, Upper Level, Ballroom 6A All AAAAI Fellows and members should attend this annual business meeting. Box lunches included. No fee. No pre-registration required.

2:00

2:15

2:30

2:45

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Oral Abstract 4603 Air Pollution/Allergens/Air Quality

Oral Abstract 4601 Adherence

2:00

2:15

2:30

2:45

3:00

2:00 to 3:15 pm Convention Center, Upper Level, Ballroom 6B Credit: 1.25 CME / 1.50 CE Moderator: Mark F. Sands, MD FAAAAI Poor Asthma Control In Older Adults Is Associated With Reduced Adherence To Controller Therapies and Inability To Afford Medications Jessica Tan, MD MPH Texting Medication Reminders For Better Asthma Control In Children and Teens Humaa M. Bhatta, DO Adherence To Prescribed Controller Therapy and Effects On Asthma Control In The Hispanic Population Of a Pediatric Disease Management Program Lyne G. Scott, MD Correlation Between Emergency Department Visits For Asthma Exacerbation and No Show Visits To Primary Care Provider In a Pediatric Population Margaret Redmond, MD Choosing Wisely: Adherence By Allergists To Recommended Use Of Spirometry In The Diagnosis and Management Of Adult Asthma Kristin C. Sokol, MD MPH

2:00 to 3:15 pm Convention Center, Upper Level, Room 11AB Credit: 1.25 CME / 1.50 CE Moderator to be announced. G Protein-Coupled Receptor Kinase-3 (GRK-3) In Bone Marrow Niche Interactions and Transplantation Jaime M. Brozowski Allogeneic Hematopoietic Stem Cell Transplantation For Immune Dysregulation, Polyendocrinopathy, X-Linked (IPEX) Syndrome Resolves Enteropathy and Autoimmunity: A Single Institution Experience Zeynep Yesim Yesim Kucuk, MD Natural Killer Cell Immunoglobulin Like Receptor (KIR) Genetic Profile Is a Strong Predictor Of Allogeneic Hematopoietic Cell Transplant Outcomes Rehan M. Faridi, PhD Transient Lymphopenia Of Infancy: A Previously Unrecognized Entity Robert Sporter, MD

2:00

2:15

2:30

2:45

3:00

2:00 to 3:15 pm Convention Center, Upper Level, Room 5AB Credit: 1.25 CME / 1.50 CE Moderator: Neil Alexis, PhD Associations Among Volatile Organic Compounds, Allergic Sensitization, and Respiratory Illness In Children With Asthma Enrolled In a Study Of Low-Income, Green Eco-Friendly Housing (The Green Housing Study) Joy Hsu, MD MSCI A Systematic Analysis Of Pollen Transcriptomes From Plant Allergens Reveals Conserved Targets Of Immune Responses Bjoern Peters Urinary Polycyclic Aromatic Hydrocarbon Metabolites and Th2 Immunity In Children Kinjal M. Hew, PhD Impact Of BMI On Ozone-Induced IL-1 In The Airways Of Human Volunteers Michelle L. Hernandez, MD Group-2 Innate Lymphoid Cells Promote Air-Pollutant Induced Airway Inflammation and Hyperresponsiveness (AHR) Qi Yang, PhD

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

67

MONDAY, MARCH 3 Oral Abstract

Oral Abstract

4604 Food Allergy

4606 Chronic Rhinosinusitis

2:00 2:15

2:30

2:45

3:00

2:00 to 3:15 pm Convention Center, Upper Level, Ballroom 6CF Credit: 1.25 CME / 1.50 CE Moderator: Rima A. Rachid, MD FAAAAI Peanut T Cell Epitope Discovery: Ara h1 and Ara h3 Manish Ramesh, MD PhD Microparticles Encapsulated With Antigen Protect Against Sensitization and Reduce Anaphylactic Reactivity In a Food Allergy Model Karen B. Chien, PhD Over-The-Counter Dietary Supplements Genistein and Ipriflavone Suppress Peanut Allergy Symptoms Lisa Chang, BS Analyzing Casein-Specific IL-4 and IL-13 Secreting T-Cells: A Reliable Tool For Diagnosis Of Cow’s Milk Allergy Benedicte Michaud, MD PhD Growth Of Children Aged 2-17 With Cow’s Milk, Peanut, and Egg Allergy In NHANES Karin Robbins, MD

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

2:00

2:15

2:30

2:45

3:00

2:00 to 3:15 pm Convention Center, Upper Level, Ballroom 6DE Credit: 1.25 CME / 1.50 CE Moderator: Anju T. Peters, MD FAAAAI The Clinical Significance Of Specific Antibody Deficiency (SAD) Severity In Chronic Rhinosinusitis (CRS) Anjeni Keswani, MD Meta-Analysis Of Gene Expression Microarrays Reveals Novel Biomarkers Consistent With Altered Functionality Of Mucosal Barrier In Patients With Chronic Rhinosinusitis Sergejs Berdnikovs, PhD Evidence For Immunoglobulin D In Patients With Chronic Rhinosinusitis Jin Young Min, MD PhD Oncostatin M Is Elevated In Chronic Rhinosinusitis and Decreases Barrier Function In Human Airway Epithelium Kathryn L. Pothoven Immunologic Changes During Chronic Rhinosinusitis Exacerbations Compared To Controls Shefali Samant, MD

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Oral Abstract Oral Abstract

4605 Epidemiology

2:00 2:15 2:30 2:45

3:00

2:00 to 3:15 pm Convention Center, Upper Level, Room 7AB Credit: 1.25 CME / 1.50 CE Moderator: Chitra Dinakar, MD FAAAAI Allergic Causes Of Death In The United States Susan J. Kim, MD Death From Anaphylaxis Is a Reassuringly Unusual Outcome Larry Borish, MD FAAAAI Allergic Rhinitis, Asthma and Cardiovascular Disease Angela M. Crans Yoon, MD Pre-Natal and Early Life Predictors Of Atopy In Canadian Children: Results Of The Family Study Tahira Batool, MBBS Association Between Antibiotic Treatment In The First Six Months Of Life and Clinical Allergic Outcomes At Ages 2 To 3 Years Kyra Jones, MEd

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

4607 Mechanisms of Asthma and Allergic Disease

2:00

2:15

2:30

2:45

3:00

2:00 to 3:15 pm Convention Center, Upper Level, Room 1AB Credit: 1.25 CME / 1.50 CE Moderator: Nora A. Barrett, MD FAAAAI Allergen Challenge Increases Peripheral Blood CD84+ ILC2 In Allergic Rhinitis David R. Scott, MD Asthma Susceptibility Due To Environmental Programming Of Innate Immunity In Utero Sarah Manners, BS Rhinovirus Challenge Augments Allergen Responsiveness In Basophils Of Atopic Asthmatics Rachana Agrawal, PhD Der p 3 Allergen Activated Ano-1 Channel On Afferent Airway Nerves Regulates Th2 Cell Responses Mayur Patil, MS Increased Serum Soluble ST2 In Asthmatic Children and Recurrent Early Wheezers Hai Lee Chung, MD PhD

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

68

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

MONDAY, MARCH 3 Late Breaking Oral Abstract Session

Q & A Workshop

4611 Basic Translational Sciences

4802 Social Media: The Future is Here

2:00

2:15

2:30

2:45

3:00

2:00 to 3:15 pm Convention Center, Mezzanine Level, Room 15AB Credit: 1.25 CME / 1.50 CE Moderators: Francisco A. Bonilla, MD FAAAAI Mitchell H. Grayson, MD FAAAAI Human TNFR2 Exhibits Bi-Directional Control over Regulatory T Cells Denise L. Faustman, MD Contribution of Sequential and Conformational IgE-Binding Epitopes to the Allergenicity of Major Peanut Allergen Ara h 2 Stephane Hazebrouck, PhD Immunocap Cellulose Displays Cross-Reactive Carbohydrate Epitopes and Can Cause False-Positive Test Results in Patients with Anti-CCD IgE Antibodies Wolfgang Hemmer, PhD The RNA-Binding Protein Hur Is Required to Control Cytokine Expression in CD4+ T Cells Ulus Atasoy, MD FAAAAI Whole-Exome Sequencing Reveals IKBKB As a Cause of Combined Immunodeficiency Talal Mousallem, MD

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Cutting-Edge Research Keynote 4701 Nanotechnology Applications in Immunology and Allergy 3:30 to 4:30 pm Convention Center, Ground Level, Exhibit Hall A Credit: 1.00 CME / 1.20 CE Moderator: Paul V. Williams, MD FAAAAI James R. Baker, Jr., MD FAAAAI Ruth Dow Doan Professor, Director, Michigan Nanotechnology Institute for Medicine and Biological Sciences Upon completion of this session, participants should be able to describe how nanotechnology can be utilized in drug delivery and disease management.

Panel Discussion Workshop 4801 Mast Cell Activation Disorders: A Plan of Attack 4:45 to 6:00 pm Convention Center, Upper Level, Room 1AB Credit: 1.25 CME / 1.50 CE Moderator: Melody C. Carter, MD Panelists: Cem Akin, MD PhD FAAAAI Lawrence B. Schwartz, MD PhD FAAAAI Catherine R. Weiler, MD PhD FAAAAI

4:45 5:00 5:15 5:30

4:45 to 6:00 pm Convention Center, Upper Level, Room 2 Credit: 1.25 CME / 1.50 CE Moderator: Melinda M. Rathkopf, MD FAAAAI Using Twitter Nathaniel D. Hare, MD FAAAAI Using Facebook Gerald B. Lee, MD Creating a Blog/Website Ves Dimov, MD Question & Answer

Upon completion of this session, participants should be able to: Discuss how the utilization of social media in allergy and immunology practices can lead to improved patient education and satisfaction; Identify a step-wise plan for the implementation and maintenance of a social media strategy; Identify and implement processes designed to protect PHI and prevent HIPAA violations when using healthcare social media.

Problem-Based Learning Workshop 4803 Making the Practice Parameters Work for You: Using a Quality Improvement Approach 4:45 to 6:00 pm Convention Center, Upper Level, Room 3 Pre-registration and ticket required. Fee: $50. Credit: 1.25 CME / 1.50 CE PBL Facilitator: Jay M. Portney, MD FAAAAI Content Lecturer: Marcus S. Shaker, MD MS FAAAAI Upon completion of this session, participants should be able to: Describe how quality improvement initiatives can be used to implement practice parameters in the clinical setting; Define fundamentals of quality improvement; Define how quality improvement initiatives can be applied in maintenance of certification requirements.

Panel Discussion Workshop 4804 Use of Gamma Globulin in Clinical Practice: Indications, Challenges, Adverse Reactions and Monitoring 4:45 to 6:00 pm Convention Center, Upper Level, Room 5AB Credit: 1.25 CME / 1.50 CE Moderator: Elena E. Perez, MD PhD FAAAAI Panelists: Mark Ballow, MD FAAAAI Vivian P. Hernandez-Trujillo, MD FAAAAI Rima A. Rachid, MD FAAAAI Upon completion of this session, participants should be able to: Discuss the relative virtues of intravenous and subcutaneous IgG therapy; Review common approaches to reducing the systemic side effects of IGIV and managing adverse reactions; Discuss how to optimize IgG replacement therapy in immunodeficiency patients to minimize infections and maintain appropriate levels of Ig with maximal benefit.

Upon completion of this session, participants should be able to: Differentiate between mast cell activation disorder, monoclonal mast cell activation syndrome and mastocytosis; Determine which objective data is useful in defining the diagnosis of each entity.

Annual Meeting Workshops Programmed by the AAAAI. Annual Meeting Workshops funded through an educational grant from Merck.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

69

MONDAY, MARCH 3 Q & A Workshop

Q & A Workshop

4805 Influenza and Pneumococcal Vaccines in Asthmatic Patients

4808 FDA: Update from the U.S. Food and Drug Administration

4:45

5:00

5:15 5:30

4:45 to 6:00 pm Convention Center, Upper Level, Ballroom 6B Credit: 1.25 CME / 1.50 CE Moderator: Pedro C. Avila, MD FAAAAI Burden of Influenza and Invasive Pneumococcal Disease in Asthmatic Patients Tina V. Hartert, MD MPH Influenza and Pneumococcal Vaccines in Asthmatic Patients: Benefits and Risks John M. Kelso, MD FAAAAI New Influenza Vaccines for the 21st Century Speaker to be announced. Question & Answer

Upon completion of this session, participants should be able to: Discuss the burden of influenza and invasive pneumococcal disease in asthmatic patients; Describe the types, benefits and risks of influenza and pneumococcal vaccines for asthmatic patients.

Year-in-Review Workshop 4806 Practical Aspects of SCID Newborn Screening

4:45 5:00 5:15 5:30

4:45 to 6:00 pm Convention Center, Upper Level, Ballroom 6CF Credit: 1.25 CME / 1.50 CE Moderator: Kathleen E. Sullivan, MD PhD FAAAAI Secondary Evaluation of SCID Screen-Positive Infants Jolan E. Walter, MD PhD PID Diagnosed Using TRECs for Newborn Screening John M. Routes, MD FAAAAI PID Cases Missed Using TRECs for Newborn Screening Jennifer M. Puck, MD Question & Answer

Upon completion of this session, participants should be able to: Review secondary evaluation of SCID screen positive infants; Identify the cases that are detected via TRECs screening; Identify PID that can be potentially missed via TRECs screening.

Q & A Workshop 4807 Standardization of Oral Food Challenges: How Golden is the Gold Standard?

4:45

5:00

5:15 5:30

4:45

5:00 5:15

5:30

4:45 to 6:00 pm Convention Center, Upper Level, Ballroom 6A Credit: 1.25 CME / 1.50 CE Moderator: F. Estelle R. Simons, MD FAAAAI Year-in-Review: An Update from the U.S. Food and Drug Administration Badrul A. Chowdhury, MD PhD FAAAAI Over-the-Counter (OTC) Marketing of Allergy Drug Products Sofia A. Chaudhry, MD Eosinophilic Asthma: Considerations for Drug Product Development Susan Lee Limb, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Review recent issues of scientific importance at FDA and their regulatory implications; Identify issues related to the over-the-counter (OTC) marketing of allergy drug products; Recognize issues in the clinical development of drug products for eosinophilic asthma.

Q & A Workshop 4809 Innate Immunity Modulators in the Lung

4:45

5:00 5:15 5:30

4:45 to 6:00 pm Convention Center, Upper Level, Room 7AB Credit: 1.25 CME / 1.50 CE Moderator: Harald E. Renz, MD Anionic Pulmonary Surfactant Phospholipids Act as a Regulator of Inflammation and Viral Infection in the Lung Dennis R. Voelker, PhD Surfactant Protein-A and D in Airway Inflamation Angela Haczku, MD PhD FAAAAI Antagonism of Toll-Like Receptor Activation in Lung Disease Anthony A. Horner, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Recognize the capacity of surfactant phospholipids in suppression of lung inflammation due to aeroallergen, bacterial infection and viral infection; Describe how surfactant protein-A suppresses lung inflammation and damage due to bacterial infection; Discuss the specificity and mechanisms of immune regulation regulated by pulmonary surfactant phospholipids and Protein-A.

4:45 to 6:00 pm Convention Center, Upper Level, Ballroom 6DE Credit: 1.25 CME / 1.50 CE Moderator: Scott H. Sicherer, MD FAAAAI The Food Challenge PRACTALL Guidelines: What are They and When Should they be Used? Hugh A. Sampson, MD FAAAAI Why do We Need to Standardize OFC Stopping Criteria: What are the Controversies? David Mark Fleischer, MD FAAAAI What is the Role of OFC in Oral Immunotherapy Trials? Kirsten Beyer, MD Question & Answer

Annual Meeting Workshops Programmed by the AAAAI. Annual Meeting Workshops funded through an educational grant from Merck.

Upon completion of this session, participants should be able to: Discuss the different methodologies for oral food challenges; Describe the controversies around objective stopping criteria and the evidence base for this; Describe how and when to use different types of challenge methodologies.

70

Allied Health Session

ticket required

fee required

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MONDAY, MARCH 3 Q & A Workshop

Q & A Workshop

4810 Allergic Inflammation: New Advances in Chemokines and Cell Signaling

4813 Stepping Down Asthma Medications: Benefits and Risks

4:45 5:00

5:15 5:30

4:45 to 6:00 pm Convention Center, Upper Level, Room 11AB Credit: 1.25 CME / 1.50 CE Moderator: David H. Broide, MB ChB FAAAAI The Role of CCL18 in Chronic Allergic Inflammation Andrew D. Luster, MD PhD Eosinophilic Esophagitis: The Role of Eotaxins and Other Chemokines Amal H. Assa’ad, MD FAAAAI Mast Cells in Chronic Allergic Inflammation Stephen J. Galli, MD Question & Answer

Upon completion of this session, participants should be able to: Discuss how chemokines such as CCL18 are important in allergic inflammation, particularly in atopic dermatitis; Identify how cytokines such as eotaxins play an important role in eosinophilic esophagitis; Describe the role of mast cells in chronic allergic inflammation and how innate mediators and Th2 inflammation exacerbate allergic disease.

4:45

5:00

5:15

5:30

4:45 to 6:00 pm Convention Center, Mezzanine Level, Room 15AB Credit: 1.25 CME / 1.50 CE Moderator: Chitra Dinakar, MD FAAAAI Which Patients May Be Good Candidates for Stepping Down Asthma Medications? Fernando D. Martinez, MD Understanding the Risks and Benefits of Stepping Down Asthma Medication John B. Hagan, MD FAAAAI Comparing Asthma Step-Down Strategies: Is “Dynamic Dosing” Ready for Prime Time? Paul M. O’Byrne, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Identify asthma patients who may be good candidates for stepping down their asthma medication; Describe the risks associated with stepping down asthma medication with the best currently available evidence; Compare and contrast different types of step down strategies.

Panel Discussion Workshop 4811 Dilemmas in the Management of Allergic Bronchopulmonary Mycosis 4:45 to 6:00 pm Convention Center, Upper Level, Room 8 Credit: 1.25 CME / 1.50 CE Moderator: Andrew J. Wardlaw, MD PhD Panelists: Leslie C. Grammer, MD FAAAAI Catherine A. Pashley, PhD Raymond G. Slavin, MD MS FAAAAI

5:00

4812 Utility of FeNO in the Diagnosis and Management of Asthma: Comparison to Other Measures

5:15 5:30

4:45 to 6:00 pm Convention Center, Mezzanine Level, Room 14AB Credit: 1.25 CME / 1.50 CE Moderator: Harold S. Nelson, MD FAAAAI The Use of FeNO in Adult Asthma Miguel J. Lanz, MD FAAAAI The Use of FeNO in Pediatric Asthma Stanley J. Szefler, MD FAAAAI Practical Implications of Implementing FeNO in Clinical Practice Joseph D. Spahn, MD Question & Answer

Upon completion of this session, participants should be able to: Describe the appropriate uses of FeNO in adults; Review the appropriate uses of FeNO in children; Discuss the practical implications of implementing FeNO in clinical practice.

Allied Health Session

5:15 5:30

Q & A Workshop

5:00

4814 Chronic Rhinosinusitis in Children

4:45

Upon completion of this session, participants should be able to: Describe which fungi can cause ABPM and how they might cause lung damage; Review the clinical spectrum of how ABPM presents; Discuss how to optimally manage ABPM.

4:45

Q & A Workshop

ticket required

fee required

4:45 to 6:00 pm Convention Center, Mezzanine Level, Room 16AB Credit: 1.25 CME / 1.50 CE Moderator: Martin Wagenmann, MD FAAAAI Pathophysiology of Chronic Rhinosinusitis in Children Daniel L. Hamilos, MD Medical Workup and Treatment of Chronic Rhinosinusitis in Children David W. Hauswirth, MD FAAAAI Surgical Treatment of Chronic Rhinosinusitis in Children Fuad M. Baroody, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Discuss the pathophysiology of CRS in children; List the workup and medical treatment of children with CRS; Review the surgical approach to CRS in children after failure of medical therapy.

Problem-Based Learning Workshop 4815 Aspirin Desensitization for Aspirin-Exacerbated Respiratory Disease: Indications, Protocols and Pitfalls 4:45 to 6:00 pm Convention Center, Upper Level, Room 31C Pre-registration and ticket required. Fee: $50. Credit: 1.25 CME / 1.50 CE PBL Facilitator: Richard W. Weber, MD FAAAAI Content Lecturer: Donald D. Stevenson, MD FAAAAI Upon completion of this session, participants should be able to: Describe indications for aspirin desensitization for aspirin exacerbated respiratory disease; Identify problems that can occur with aspirin desensitization and develop strategies for how to deal with these problems.

included in the Virtual Annual Meeting

71

MONDAY, MARCH 3 Seminars 4:45 to 5:45 pm Pre-registration and ticket required. Fee: $40. Refreshments included. Sessions and refreshments are limited to 30 people. Credit: 1.00 CME / 1.20 CE

4821 From Urticaria to Toxic Epidermal Necrolysis: Cutaneous Drug Eruptions for the Clinician Jennifer S. Kim, MD FAAAAI Peter A. Lio, MD Marriott South Tower, Level 3, Marina Ballroom Salon G

4826 Exercise-Induced Anaphylaxis and FoodDependent Exercise-Induced Anaphylaxis Anna M. Feldweg, MD Kirsi M. Jarvinen-Seppo, MD PhD Marriott South Tower, Level 1, Point Loma Upon completion of this session, participants should be able to: Review the most common clinical presentations of EIAn and typical foods that can trigger FD-EIAn; Identify recent publications relevant to EIAn and FD-EIAn; Increase understanding of treatment options for EIAn and FD-EIAn.

4827 Physical Urticarias Mario Geller, MD FAAAAI Karen S. Hsu Blatman, MD Marriott South Tower, Level 1, Solana

Upon completion of this session, participants should be able to: Evaluate cutaneous drug eruptions and render a diagnosis with confidence; Analyze evidence-based medicine to current therapeutic options for these conditions.

4822 Smoking and Asthma: Not Just Blowing Smoke Riccardo Polosa, MD PhD FAAAAI Mark F. Sands, MD FAAAAI Marriott South Tower, Level 3, Balboa

Upon completion of this session, participants should be able to: Identify physical urticarias; Evaluate and educate patients with physical uticarias; Manage and treat physical urticarias with the recent data.

4828 Advanced Coding for the Allergist

Upon completion of this session, participants should be able to: Describe the pathophysiologic consequences of tobacco smoking upon the asthmatic; Discuss the effect of tobacco smoke on the lung from fetus through adult life; Describe effective smoking cessation interventions.

4823 Gene Therapy for Primary Immunodeficiency Disorders: Where are We in 2014? Fabio Candotti, MD Matthew Porteus, MD PhD Marriott South Tower, Level 3, Mission Hills Upon completion of this session, participants should be able to: Review the primary immunodeficiency disorders for which gene therapy is a treatment option; Discuss the mechanism of gene therapy; Discuss limitations and risks associated with gene therapy.

4824 Occupational Respiratory Diseases André Cartier, MD FAAAAI Susan M. Tarlo, MBBS FAAAAI Marriott South Tower, Level 3, Cardiff Upon completion of this session, participants should be able to: Recognize the history clues pointing to potential work-related asthma; Develop familiarity with the approach needed to establish the diagnosis of occupational asthma; Compare the strengths and weaknesses of the tools available to establish work-relatedness.

4825 Asthma Management Among Minority Populations: Practical Insights for Clinicians, Researchers and Public Health Planners

Noga Askenazi, MD FAAAAI Gary N. Gross, MD FAAAAI Marriott South Tower, Level 1, Santa Rosa Upon completion of this session, participants should be able to: Discuss the use of codes pertinent to allergy/immunology practice; Describe details of coding for patients’ allergy testing and immunotherapy.

4829 Immunodeficiencies Discovered in the Last Five Years Francisco J. Espinosa-Rosales, MD Gulbu Uzel, MD Marriott South Tower, Level 4, La Costa Upon completion of this session, participants should be able to: Discuss the new primary immunodeficiency diseases with a focus on those described during the past five years; Describe the newer technologies used for discovery of these and future disorders; Identify the expanding overlap between immunodeficiency and inflammatory disorders.

4830 Management of Children and Adult Patients with Atopic Dermatitis Jon M. Hanifin, MD FAAAAI Dagmar Simon, MD Marriott South Tower, Level 4, Catalina Upon completion of this session, participants should be able to: Describe the presentation, pathophysiology and complications of atopic dermatitis; Discuss the management of these patients, including their education; Discuss possible therapeutic consequences due to new insights into the pathogenesis of atopic dermatitis.

Alan P. Baptist, MD MPH FAAAAI Christine L.M. Joseph, PhD Marriott South Tower, Level 3, Del Mar Upon completion of this session, participants should be able to: Identify the healthcare disparities that exist in asthma care; Discuss reasons why these disparities exist; Discuss effective strategies to treat minority populations, thereby decreasing health disparities in asthma.

Annual Meeting Seminars Programmed by the AAAAI. Annual Meeting Seminars funded through an educational grant from Merck.

72

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

TUESDAY, MARCH 4 Seminars

5008 Challenges of Managing Multiple Food Allergies

7:00 to 8:00 am Pre-registration and ticket required. Fee: $40. Continental breakfast included. Sessions and meals are limited to 30 people. Credit: 1.00 CME / 1.20 CE

5001 Corticosteroid Resistance in Asthma Elena Goleva, PhD Faoud T. Ishmael, MD PhD FAAAAI Marriott South Tower, Level 3, Balboa

Julie Wang, MD FAAAAI Michael C. Young, MD FAAAAI Marriott South Tower, Level 4, Catalina Upon completion of this session, participants should be able to: Identify the diagnostic and management challenges of multiple food allergies; Recognize the nutritional, feeding and social risk factors; Develop and implement a feeding plan for adequate nutrition, feeding skill and social development of children with multiple food allergies.

5009 SLIT vs. SCIT in Children

Upon completion of this session, participants should be able to: Discuss current approaches for clinical evaluation of potential insensitivity to oral and inhaled CS; Describe glucocorticoid receptor function and current understanding of the molecular pathways that lead to CS insensitivity; Explain the interaction of the glucocorticoid receptor with other steroid receptor regulated pathways, i.e. vitamin D, sex hormones, etc.; Discuss management of patients with suspected CS insensitivity and alternative therapeutic strategies for these patients.

Giovanni Passalacqua, MD David P. Skoner, MD Marriott South Tower, Level 4, Coronado Upon completion of this session, participants should be able to: Summarize experience with SLIT and compare and contrast its safety/efficacy vs. SCIT; Appreciate recent data describing SLIT; Appreciate methodologic variation in SLIT.

Q & A Workshop

5002 Rethinking Allergen Avoidance Elizabeth Matsui, MD Euan R. Tovey, PhD Marriott South Tower, Level 3, Mission Hills

5051 Glycobiology and Glycoimmunology: From Concepts to Clinical Relevance

Upon completion of this session, participants should be able to: Define current guidelines for allergen avoidance in asthma management; Describe methods of reducing allergen exposure and evidence based studies of their effectiveness; Discuss new strategies for allergen avoidance that take into account the complex interactions between allergens, the innate immune system and genetic markers.

6:45

5003 Role of Allergy in Atopic Dermatitis 7:00

Johannes Ring, MD PhD FAAAAI Marriott South Tower, Level 3, Cardiff Upon completion of this session, participants should be able to: Review practical relevance of aero-food and contact allergic reactions in triggering flairs of AD; List practical tips for management with regard to restoring disturbed barrier function in AD.

7:15

5004 Cases of Patients with Chronic Cough

7:30

6:45 to 8:00 am Convention Center, Upper Level, Room 2 Credit: 1.25 CME / 1.50 CE Moderator: Nives Zimmermann, MD FAAAAI Cell Surface Sialic Acids: The ‘Dark Matter’ of Immune Regulation Ronald L. Schnaar, PhD Induction of Tolerance by Targeting B Cell Siglecs James C. Paulson, PhD Sialic Acid Recognition is Key to Immune Regulation-Role of Siglecs Bruce S. Bochner, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Explain sialic acid biosynthesis and its role in human biology; Define the role that glycans play in immune recognition and regulation.

Mandel R. Sher, MD FAAAAI Gary J. Stadtmauer, MD FAAAAI Marriott South Tower, Level 1, Point Loma Upon completion of this session, participants should be able to describe various diagnostic and treatment techniques for patients with chronic cough.

Problem-Based Learning Workshop 5052 An Allergists' Vision of Ocular Diseases: A CaseBased Approach

5005 New Insights into IgE Biology Hannah J. Gould, PhD Marriott South Tower, Level 1, Solana Upon completion of this session, participants should be able to: Identify the regulation of IgE production in B cells; Describe the acquisition of IgE by tissue mast cells; Identify the effects of IgE activation on tissue mast cells in inflammation.

5006 Exhaled NO: Time to Clear the Air! Chitra Dinakar, MD FAAAAI Stanley J. Szefler, MD FAAAAI Marriott South Tower, Level 1, Santa Rosa Upon completion of this session, participants should be able to: Discuss the application of eNO in the context of ATS guidelines and AAAAI/ACAAI position statements; Recognize the relationship between the levels of evidence and practice guidelines for clinical eNO use; Explain potential weaknesses/strengths of eNO for managing asthmatics.

6:45 to 8:00 am Convention Center, Upper Level, Room 3 Pre-registration and ticket required. Fee: $50. Credit: 1.25 CME / 1.50 CE PBL Facilitator: Andrew M. Smith, MD FAAAAI Content Lecturer: Neal P. Barney, MD Upon completion of this session, participants should be able to: Describe the pathophysiology of ocular conditions commonly encountered in the allergy clinic; Facilitate interaction between allergists and ophthalmologists and explain how each plays a complementary role in the management of ocular allergy; Discuss allergic diseases which present in different age groups (children, young adults and elderly) and how their diagnoses and management are different.

5007 Perioperative Anaphylaxis: Which Tests and How to Interpret Gerald W. Volcheck, MD FAAAAI Marriott South Tower, Level 4, La Costa Upon completion of this session, participants should be able to explain to patients the meaning of allergy tests performed for perioperative anaphylaxis.

Allied Health Session

ticket required

fee required

Annual Meeting Workshops Programmed by the AAAAI. Annual Meeting Workshops funded through an educational grant from Merck.

included in the Virtual Annual Meeting

73

TUESDAY, MARCH 4 Q & A Workshop

Plenary

5053 Impact of Climate Change on Indoor and Outdoor Aeroallergens

5101 Bioaerosols: When Not to Take a Deep Breath at Work

6:45 7:00 7:15 7:30

6:45 to 8:00 am Convention Center, Upper Level, Room 5AB Credit: 1.25 CME / 1.50 CE Moderator: Estelle Levetin, PhD FAAAAI Overview of the Impact of Climate Change Charles S. Barnes, PhD Changing Patterns of Aeroallergens and Pollens Around the World John R. Cohn, MD FAAAAI Impacts On the Indoor Environment Jonathan A. Bernstein, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Identify two recent reports on the impact of climate change on environmental exposures; Describe changes documented to date on indoor and outdoor allergen exposures that have been related to climate change adaptation factors; Discuss future factors that might be directly or indirectly related to climate change and changes in environmental exposures; Discuss appropriate changes in allergy practice in response to changing environmental exposures.

8:15 8:45

9:15

Upon completion of this session, participants should be able to: State the health effects of bioaerosol exposure on health in office building workers; Discuss the immunologic mechanisms of respiratory disease associated with working in large animal confinement feeding operations; Describe bioaerosol sampling methods and exposure risk for health effects in textile manufacturing workers.

Posters

Q & A Workshop

7:00 am to 5:00 pm Convention Center, Ground Level, Exhibit Hall B Posters on display from 7:00 am to 5:00 pm. Authors present from 9:45 to 10:45 am. Credit: No CME / No CE Refer to pages 83 – 158 for abstracts and authors.

5054 Teaching Allergy and Immunology to Residents and Medical Students: An Achievable Goal for the Clinical Allergist

6:45 7:00 7:15 7:30

8:15 to 9:45 am Convention Center, Ground Level, Exhibit Hall A Credit: 1.50 CME / 1.80 CE Moderator: Leslie C. Grammer, MD FAAAAI Office: Building-Related Illness Jean M. Cox-Ganser, PhD Agriculture: Respiratory Illness in Large Animal Farming Environments Jill A. Poole, MD FAAAAI Factory: Occupational Illness in the Textile Industry David C. Christiani, MD

6:45 to 8:00 am Convention Center, Upper Level, Room 8 Credit: 1.25 CME / 1.50 CE Moderator: Mark H. Moss, MD The Six Core Compentencies Asriani M. Chiu, MD FAAAAI Designing a Clinical Rotation Lily Pien, MD FAAAAI Teaching from a Practitioner’s Perspective: What Works Stephen A. Tilles, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Identify the six core competencies of postgraduate medical training; Describe resources to enhance teaching of trainees in the office setting; Discuss qualities of a clinical rotation that lend value to a medical training program.

5201 5202 5203 5204 5205 5206 5207 5208 5209 5211

The Impact of Environmental Factors on Asthma Diagnostic Modalities of Asthma Basic and Translational Immunology Innate Immunity and Primary Immunodeficiencies Epidemiology and Risk Factors of Asthma Eosinophilic Gastrointestinal Diseases Drug Allergy Ocular Allergy Allergen Immunotherapy Late Breaking Poster Session

Annual Meeting Workshops Programmed by the AAAAI. Annual Meeting Workshops funded through an educational grant from Merck.

74

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

TUESDAY, MARCH 4 Symposium

Symposium

5301 The Road to Allergy: Soluble Instructions to Dendritic Cells

5304 Angioedema with Negative Family History

10:45 11:05 11:25 11:45

10:45 am to 12:00 pm Convention Center, Upper Level, Room 5AB Credit: 1.25 CME / 1.50 CE Moderator: Dawn C. Newcomb Baker, PhD Cysteinyl Leukotrienes are Endogenous Signaling Molecules Nora A. Barrett, MD FAAAAI Inhibition of Th2 Priming by the UDP Receptor P2Y6 Joshua A. Boyce, MD FAAAAI Platelets Dictate Th2 Sensitization: The Role of Serotonin Marco Idzko, MD Question & Answer

Upon completion of this session, participants should be able to: Recognize the role cysteinyl leuktrienes play as signaling molecules in dendritic cells; Identify the counterregulatory role of the purinergic 6 receptor; Identify the role of serotonin in Th2 priming.

Symposium

11:05 11:25 11:45

10:45 am to 12:00 pm Convention Center, Upper Level, Room 7AB Credit: 1.25 CME / 1.50 CE Moderator: Anju T. Peters, MD FAAAAI Is More and Longer Better? Long-Term and High-Dose Glucocorticosteroids Joaquim Mullol, MD PhD FAAAAI Treating With the Cause of Trouble: ASA-Desensitization Katharine M. Woessner, MD FAAAAI The Road to Future: Will Biologics Improve Treatment? Claus Bachert, MD PhD Question & Answer

Upon completion of this session, participants should be able to: Contrast the limitations and possibilities of high-dose or long-lasting glucocorticosteroid treatment in recurrent chronic rhinosinusitis with nasal polyps; Identify suitable patient subgroups, success rates and limitations of aspirin desensitization; Outline the pathophysiological basis and current knowledge about anti-IgE and anti-IL-5 treatment in nasal polyposis.

Symposium 5303 Atopic Dermatitis

10:45 11:05 11:25 11:45

11:05 11:25 11:45

Upon completion of this session, participants should be able to: Discuss mechanisms and clinical aspects of recurrent angioedema caused by angiotensin-converting enzyme inhibitors; Review the differential diagnosis and management issues of idiopathic angioedema; Describe the management of idiopathic angioedema.

Symposium

5302 What to Do When Everything Fails: Treatment Options for Severe Chronic Rhinosinusitis

10:45

10:45

10:45 am to 12:00 pm Convention Center, Upper Level, Room 11AB Credit: 1.25 CME / 1.50 CE Moderator: Michael M. Frank, MD FAAAAI New Developments in Angioedema Caused by AngiotensinConverting Enzyme Inhibitors Marco Cicardi, MD PhD Diagnosis of Idiopathic Angioedema Marc A. Riedl, MD MS Management of Idiopathic Angioedema Aleena Banerji, MD Question & Answer

5305 Innate Cytokines and the Regulation of Allergy

10:45

11:05

11:25

11:45

10:45 am to 12:00 pm Convention Center, Mezzanine Level, Room 14AB Credit: 1.25 CME / 1.50 CE Moderator: Zoulfia Allakhverdi, PhD FAAAAI Role of Epithelial-Derived Cytokines in the Initiation and Pathogenesis of Allergy Clare M. Lloyd, PhD Cross-Regulatory Mechanisms of Interferon and Allergic Stimulation J. David Farrar, PhD Modulation of Innate Cytokines by TLR Agonists to Achieve Tolerance Speaker to be announced. Question & Answer

Upon completion of this session, participants should be able to: Identify the key cytokines secreted by lung epithelial cells in response to infections and the role of these cytokines in priming of the allergic condition; Describe the role of type I and III interferons in the suppression of Th2 and Th17 responses and the inhibition of interferon secretion by allergic stimulation through the high affinity IgE Fc receptor; Discuss how TLR ligands, such as CpG oligonucleotides, are being used to mediate allergic suppression through the induction of cross-regulatory cytokines.

10:45 am to 12:00 pm Convention Center, Upper Level, Room 2 Credit: 1.25 CME / 1.50 CE Moderator: Lynda C. Schneider, MD FAAAAI Barrier Defects in Atopic Dermatitis Anna De Benedetto, MD Atopic Dermatitis as a Global Burden Peter Schmid-Grendelmeier, MD PhD New Treatment Modalities Mark Boguniewicz, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Discuss atopic dermatitis; Identify and use appropriate diagnostic tools; Demonstrate efficient, safe and state-of-theart treatment.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

75

TUESDAY, MARCH 4 Symposium

Course

5306 B Cells and Mucosal Immune Responses in Health and Disease

5311 Mechanisms of Allergic Inflammation

10:45

11:05

11:25 11:45

10:45 am to 12:00 pm Convention Center, Mezzanine Level, Room 15AB Credit: 1.25 CME / 1.50 CE Moderator: Atsushi Kato, PhD Mucosal Immunity: Balancing Immune Responses at the Forefront of Microbial Exposure Andrea Cerutti, MD Immunity and B Cells in the Gut: From Immune Exclusion to Food Allergy Cecilia Berin, PhD B Cells and Respiratory Immunity Kathryn E. Hulse, PhD Question & Answer

Upon completion of this session, participants should be able to: Outline how the mucosal immune system balances responses to commensal and pathogenic microbes; Describe the unique role of B cells and their antibodies in maintaining tolerance and homeostasis at mucosal sites; Identify how mucosal B cell responses may be dysregulated in allergic disease as a strategy for the development of more targeted therapeutic interventions.

Symposium

10:45 10:50

11:15 11:20

11:45 11:50 12:15 12:20 12:40

5307 Inflammasome Disorders: Here and Now

10:45 11:05 11:25 11:45

10:45 am to 12:00 pm Convention Center, Mezzanine Level, Room 16AB Credit: 1.25 CME / 1.50 CE Moderator: John W. Steinke, PhD FAAAAI Nuts and Bolts of Inflammasome Biology Daniel L. Kastner, MD Inflammasome Associated Diseases: The Old and New Monica G. Lawrence, MD Treatment Options for Inflammasome Disorders Hal M. Hoffman, MD FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Describe the basics of how the inflammasome works; Outline the current state of inflammasome disorders and what is new in the field; Discuss novel therapeutic approaches to treating inflammasome disorders.

76

12:45 1:10 1:15

1:40

10:45 am to 1:45 pm Convention Center, Upper Level, Room 4 Pre-registration and ticket required. Fee: $40. Box lunch included. Credit: 2.75 CME / 3.20 CE Moderator: Mitchell H. Grayson, MD FAAAAI Introduction: Control of Type 2 Immunity Mitchell H. Grayson, MD FAAAAI Transcriptional Cross-Regulation of Th1 and Th2 Cell Differentiation Jinfang Zhu, PhD Question & Answer Location, Location, Location: Dendritic Cells, B Cells and Th2 Development Frances E. Lund, PhD Question & Answer From Friend to Foe: T Regs Acting Th2 Prabir Ray, PhD Question & Answer Break Introduction: Novel Concepts in Immunoglobulin E and its Receptors Mitchell H. Grayson, MD FAAAAI Breaking Up is Hard to Do: Disassembly of IgE and FceRI Theodore S. Jardetzky, PhD Question & Answer Exclusivity: IgE Binding to CD23 or FceRI Hannah J. Gould, PhD Brian Sutton, MA DPhil Question & Answer

Upon completion of this session, participants should be able to: Describe mechanisms through which t-bet is able to suppress Th2 responses and discuss how dendritic cells and B cells drive Th2 development outside of the T cell zone; Review how a viral respiratory infection can induce Th2 cytokine production from regulatory T cells; Discuss how macromolecules can disrupt IgE-FcεRI complexes and how IgE interacts with CD23 and how this prevents binding to FcεRI and vice versa.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

TUESDAY, MARCH 4 Course

Course

5312 Developing Clinical Skills to Promote Adherence and Maximize Asthma Outcomes

5314 Owning the Bone: How to Minimize Glucocorticoid-Induced Osteoporosis Risk

11:15

11:45 12:15 12:30

1:00

1:30

10:45 am to 1:45 pm Convention Center, Upper Level, Room 3 Pre-registration and ticket required. Fee: $40. Box lunch included. Credit: 2.75 CME / 3.30 CE Moderator: Marcus S. Shaker, MD MS FAAAAI Clinical Management Strategies to Promote Adherence of Pediatric Asthma Patients and Families Cynthia S. Rand, PhD Methods to Diagnose Adherence Status Andrew G. Weinstein, MD FAAAAI Break Shared Decision Making: A Communication Practice Proven to Enhance Adult Asthma Patients’ Adherence and Outcomes Sandra R. Wilson, PhD The Role of Motivational Interviewing to Help Guide Patients to Favorable Asthma Management Actions Belinda Borrelli, PhD Question & Answer

Upon completion of this session, participants should be able to: Identify the reasons why patients are non-adherent with health care providers’ plans; Discuss objective means to diagnose adherence status; Demonstrate motivational interviewing and other patientcentered techniques to help patients and families follow asthma treatment plans.

10:45 11:15 11:45 12:00 12:30

1:00 1:30

10:45 am to 1:45 pm Convention Center, Upper Level, Room 8 Pre-registration and ticket required. Fee: $40. Box lunch included. Credit: 2.75 CME / 3.30 CE Moderator: Joshua A. Steinberg, MD Cellular Mechanisms of Glucocorticoid Action in Bone Ernesto Canalis, MD Bone Biomechanics and Glucocorticoid Effects Bjoern Buehring, MD Break Corticosteroids and Bone Accretion Kelan Tantisira, MD MPH Influence of Diet and Lifestyle on Glucocorticoid-Induced Osteoporosis Mary C. Tobin, MD FAAAAI Incorporating Best Bone Health Care into Allergy Practice Andrea J. Apter, MD MA MSc FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Identify known bone health risks of acute and chronic exposure to inhaled and oral glucocorticoids; Recognize differences between GIOP and post-menopausal osteoporosis pathophysiology, risk factors and screening tools; Discuss present and emerging guidelines and pharmacotherapy in the prevention and management of GIOP.

Course 5313 Mechanisms and Treatment of Exacerbations of Asthma

10:45 11:10 11:35

12:00 12:15 12:40 1:05 1:30

10:45 am to 1:45 pm Convention Center, Upper Level, Room 1AB Pre-registration and ticket required. Fee: $40. Box lunch included. Credit: 2.75 CME / 3.30 CE Moderators: James E. Gern, MD FAAAAI Daniel J. Jackson, MD Role of Viruses Eva Kathryn Miller, MD Role of Bacteria Hans Bisgaard, MD DMSci How Does Allergic Inflammation Alter the Immune Response to Viruses? Peter W. Heymann, MD Break Etiology of Exacerbations in Different Populations Malcolm R. Sears, MD FAAAAI Identifying the Exacerbation-Prone Patient Ronina A. Covar, MD Approaches to the Prevention and Treatment of Exacerbations Daniel Jackson, MD Question & Answer

Upon completion of this session, participants should be able to: List the most common viruses and bacteria associated with asthma exacerbations; Discuss mechanisms of virus-allergen interactions that promote exacerbations; List major risk factors for exacerbations of asthma.

Allied Health Session

ticket required

fee required

Pro/Con Debate 5502 Adaptive Immune Responses are Essential 12:30 to 1:30 pm Convention Center, Upper Level, Room 5AB Credit: 1.00 CME / 1.20 CE Moderator: Larry Borish, MD FAAAAI Pro Erwin W. Gelfand, MD FAAAAI Con Hirohito Kita, MD Upon completion of this session, participants should be able to discuss the increasingly important role of ILC2 lymphocytes in generating allergic airway inflammation.

Pro/Con Debate 5503 Anti-Fungals are Effective in Treating Allergic Fungal Airway Disease 12:30 to 1:30 pm Convention Center, Upper Level, Room 11AB Credit: 1.00 CME / 1.20 CE Moderator: Jeffrey G. Demain, MD FAAAAI Pro Daniel L. Hamilos, MD FAAAAI Con Andrew J. Wardlaw, MD PhD Upon completion of this session, participants should be able to: Identify the clinical trials and case series that have described the use of anti-fungals in fungal associated asthma; List the pros and cons of using anti-fungal agents in ABPA and related conditions.

included in the Virtual Annual Meeting

77

TUESDAY, MARCH 4 Pro/Con Debate

Seminars 12:30 to 1:30 pm Pre-registration and ticket required. Fee: $40. Box lunch included. Sessions and meals are limited to 30 people. Credit: 1.00 CME / 1.20 CE

5504 The Diagnosis of Asthma vs. COPD Does Not Affect Treatment 12:30 to 1:30 pm Convention Center, Mezzanine Level, Room 14AB Credit: 1.00 CME / 1.20 CE Moderator: Michael E. Manning, MD FAAAAI Pro Stephen P. Peters, MD PhD FAAAAI Con Nicola A. Hanania, MD

5521 Approach to the Evaluation of Immunodeficiency in Adults Adina Kay Knight, MD FAAAAI Joyce E. Yu, MD Marriott South Tower, Level 1, Point Loma

Upon completion of this session, participants should be able to: Describe how COPD and asthma can be differentiated; Compare and contrast treatment options and treatment expectations in COPD vs. asthma.

Upon completion of this session, participants should be able to: Discuss the workup and management of adults with suspected immunodeficiency; Compare and contrast the differential diagnosis for hypogammaglobulinemia in adult patients; List key differences between the immunodeficiency diagnostic spectrum in adults vs. adolescents and children.

5522 Office Evaluation of Patients with Multiple Antibiotic Allergies

Pro/Con Debate 5505 Epinephrine Should be Prescribed to All Allergen Immunotherapy Patients (SLIT and SCIT) 12:30 to 1:30 pm Convention Center, Mezzanine Level, Room 15AB Credit: 1.00 CME / 1.20 CE Moderator: Linda Cox, MD FAAAAI Pro Dana V. Wallace, MD FAAAAI Con John Oppenheimer, MD FAAAAI

Roland Solensky, MD FAAAAI Marriott South Tower, Level 1, Solana Upon completion of this session, participants should be able to describe how to approach patients with multiple antibiotic allergies with appropriate diagnostic testing and challenge procedures.

5523 Novel Therapies for Chronic Urticaria and Angioedema David H. Dreyfus, MD PhD FAAAAI Marriott South Tower, Level 1, Santa Rosa

Upon completion of this session, participants should be able to: Discuss the safety of SCIT with emphasis on timing and severity of reactions; Discuss safety of SLIT in the reported studies and surveys.

Upon completion of this session, participants should be able to: Discuss novel therapy for chronic urticaria and angioedema; Describe novel diagnostic testing for chronic urticaria and angioedema; Review practical considerations for application of novel therapy and diagnosis.

5524 Tree Nut and Peanut: Complexity in CrossReactivity

Pro/Con Debate

Soheila J. Maleki, PhD Suzanne S. Teuber, MD FAAAAI Marriott South Tower, Level 4, La Costa

5506 Androgens are the Best Option for Prophylactic Treatment of Hereditary Angioedema 12:30 to 1:30 pm Convention Center, Mezzanine Level, Room 16AB Credit: 1.00 CME / 1.20 CE Moderator: Bruce L. Zuraw, MD Pro Marco Cicardi, MD PhD Con Marc A. Riedl, MD MS

Upon completion of this session, participants should be able to: Distinguish between clinical cross-reactivity and in vitro cross-reactivity; List the main seed storage proteins involved in cross-reactivity; Review the closely related tree nuts that are often clinically cross-reactive.

5525 Chronic Rhinosinusitis Subtypes and Implications for Treatment

Upon completion of this session, participants should be able to: List the benefits and risks of androgens for prophylaxis in HAE; Discuss the risks and benefits of C1 inhibitor therapy for prophylaxis in HAE; Compare and contrast the use of androgens vs. C1 inhibitor therapy for prophylaxis in HAE.

Joseph K. Han, MD Amber U. Luong, MD PhD Marriott South Tower, Level 4, Catalina Upon completion of this session, participants should be able to: Describe the classification of sinusitis; Describe the clinical subtypes of chronic rhinosinusitis; Explain the different non-surgical treatment options for the different chronic rhinosinusitis subtypes.

Annual Meeting Seminars Programmed by the AAAAI. Annual Meeting Seminars funded through an educational grant from Merck.

78

Allied Health Session

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TUESDAY, MARCH 4 Oral Abstract

Oral Abstract

5601 Asthma Epidemiology and Risk Factors

5603 Environmental Risk Factors and Disease Outcomes

2:00

2:15

2:30

2:45

3:00

2:00 to 3:15 pm Convention Center, Upper Level, Room 5AB Credit: 1.25 CME / 1.50 CE Moderators: Ronina A. Covar, MD Timothy J. Craig, DO FAAAAI Exposures That Alter The Early Life Microbiome and The Risk Of Asthma Amy S. Feldman, MD Ethnic Differences Of Reported Asthma Symptoms In Urban School-Based Screening Surveys Margee Louisias, MD Year One Daycare Attendance Predicts Asthma At Age Seven: The Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS) Gang Cheng, MD PhD Determining Risk Levels Of The Composite Asthma Severity Index (CASI) Rebecca A. Zabel BMI and Asthma Severity In An Elementary and Middle School Inner City Population Christina G. Kwong, MD

2:00

2:15

2:30

2:45

3:00

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Oral Abstract 5602 Basic and Translational Immunology

2:00

2:15

2:30 2:45

3:00

2:00 to 3:15 pm Convention Center, Upper Level, Room 1AB Credit: 1.25 CME / 1.50 CE Jonathan A. Bernstein, MD FAAAAI Moderator: James. L. Sublett, MD FAAAAI Effect Of Prenatal Exposure To Indoor PM2.5 and Environmental Tobacco Smoke Affecting Lower Respiratory Tract Infection Was Modified By ROS Genes: Cocoa Study Song I. Yang, MD IgE Anti-Respiratory Syncytial Virus Antibodies In Older Asthmatic Children Mira Mandal Asthma Symptoms and Rhinovirus In A Longitudinal Children’s Cohort Euan R. Tovey, PhD Maternal Transfer Of Der p 1 and Blo t 5 Allergens and Their Respective Specific Antibodies Trough Placenta and Colostrum Patricia Macchiaverni Rhinovirus Infection Is Associated With Changes In The Airway Microbiome Kirsten Kloepfer, MD

2:00 to 3:15 pm Convention Center, Upper Level, Room 7AB Credit: 1.25 CME / 1.50 CE Moderator: TBA Novel NK Cytotoxicity Assay Enables Drug Discovery For Hemophagocytic Lymphohistiocytosis Jinzhu Li, MD PhD Exploitation Of The Host Ubiquitin System By Respiratory Syncytial Virus Nonstructural Protein 2 Jillian N. Whelan Epigenetic Regulation Of Dendritic Cell Migration Timothy P. Moran, MD PhD LRBA Subcellular Localization: Evidence Of The LRBA’s Role In Vesicle Trafficking From The Golgi To Cell Membrane and Endocytosis Michelle A. Reiser, MS Differential Role Of Dendritic Cell Subsets In Shaping T-Cell Responses To Respiratory Viruses Meera Rani Gupta, MD

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Oral Abstract 5604 Eosinophilic Gastrointestinal Diseases

2:00

2:15

2:30

2:45 3:00

2:00 to 3:15 pm Convention Center, Upper Level, Room 2 Credit: 1.25 CME / 1.50 CE Moderator: Antonella Cianferoni, MD PhD Natural History Of Esophageal Remodeling In Pediatric Eosinophilic Esophagitis Treated For Four Years Jessica Rajan, MD Diagnostic Inaccuracy Of Biopsy Evaluations In Eosinophilic Esophagitis Underscores The Value Of a Secondary Review Process Emily Stucke, BA Development Of Eosinophilic Esophagitis To Food After Development Of IgE Tolerance To The Same Food Solrun Melkorka Maggadottir, MD Mast Cells, Eosinophils and Eosinophilic Esophagitis Jay Jin, MD PhD CD3 and CD8 Cells Produce IL-9 In Pediatric Eosinophilic Esophagitis Arjun Andrew Anilkumar, BS

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

79

TUESDAY, MARCH 4 Oral Abstract

Oral Abstract

5605 Population Health and Food Allergy

5607 Mechanisms of T Cell-Mediated Allergic Disease

2:00

2:15

2:30 2:45

3:00

2:00 to 3:15 pm Convention Center, Upper Level, Room 11AB Credit: 1.25 CME / 1.50 CE Moderator: Marcus S. Shaker, MD MS FAAAAI Longitudinal Effect Of Food Allergy Education On Epinephrine Availability In Public Schools Dipika Patel, MD Population Response To Change In Infant Feeding Guidelines For Allergy Prevention Dean Tey, MD Teasing and Bullying Among Adolescents With Food Allergy Adora Lin, MD PhD Differences In Food Allergy Quality Of Life Between Caregivers In a Clinic-Based and a Caregiver-Reported Food Allergic Population Matthew J. Greenhawt, MD MBA MSc Food Allergy Management In An Urban Pediatric Population Jennifer M. Camacho, MD

2:00

2:15

2:30

2:45

3:00

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Oral Abstract

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

5606 New Forms of Immunotherapy

2:00

2:15

2:30

2:45

3:00

2:00 to 3:15 pm Convention Center, Mezzanine Level, Room 15AB Credit: 1.25 CME / 1.50 CE Moderator: Taylor A. Doherty, MD FAAAAI TSLP Induces Corticosteroid Resistance In Natural Helper Cells Via STAT5 Pathway Hiroki Kabata Impairment Of IL-27’s Differential Effect On CD4+T Cells In Asthma Zhihong Chen Profile Of Food Allergen-Specific T Cells In Allergic and Clinically Tolerant Individuals David Chiang, MS Follicular Helper T Cells Mediate IgE Antibody Production and Allergic Immune Responses in Mice Takao Kobayashi, PhD Analysis Of Circulating Rhinovirus-Specific CD4+ T Cells Using Novel MHC Class II Tetramers Reveals Marked Expansion Of Effector Memory Cells In Infected Subjects Lyndsley Muehling

2:00 to 3:15 pm Convention Center, Mezzanine Level, Room 14AB Credit: 1.25 CME / 1.50 CE Moderator: Désirée E.S. Larenas Linnemann, MD FAAAAI Persistent Treatment Effect Achieved At One Year After Four Doses Of Der p Derived Synthetic Peptide Immuno-Regulatory Epitopes In An Exposure Chamber Model Of House Dust Mite Allergy Rod Hafner, PhD Treatment With Synthetic Peptide Immuno-Regulatory Epitopes Derived From Grass Allergens Leads To a Substantial Reduction In Grass Allergy Symptoms In The Environmental Exposure Unit Anne K. Ellis, MD MSc FAAAAI Epicutaneous Immunotherapy Induces Epigenetic Changes In Sensitized Mice Lucie Mondoulet, PhD Ultra-Fast Hypoallergenic Birch Pollen Allergy Vaccine Allert Is Efficient and Safe: Results Of a Phase IIb Study Francois Spertini, MD Stable Conjugates Between A Novel Toll-Like Receptor 7 Ligand and Protein Allergens As Modulators Of Th2 Responses In Vitro and In Vivo Lucia Fili

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

Late Breaking Oral Abstract Session 5611 Clinical Sciences

2:00

2:15

2:30

2:45

3:00

2:00 to 3:15 pm Convention Center, Upper Level, Room 8 Credit: 1.25 CME / 1.50 CE Moderator: Jeffrey G. Demain, MD FAAAAI Giselle Mosnaim, MD MS FAAAAI Efficacy and Safety of Lebrikizumab in Severe Uncontrolled Asthma: Results from the Lute and Verse Phase II Randomized, Double-Blind, Placebo-Controlled Trials Nicola A. Hanania, MD Dose-Finding Efficacy and Safety Trial of House Dust Mite Sublingual Immunotherapy Tablet, MK-8237, Using an Environmental Exposure Chamber Hendrik Nolte, MD, PhD Long-Lasting Egg Consumption in Egg Allergic Children Treated with Oral Immunotherapy (OIT): Follow-up from the Consortium of Food Allergy Research (CoFAR) Study Stacie M. Jones, MD A Randomized, Double-Blind, Placebo-Controlled Trial of Omalizumab Combined with Oral Immunotherapy (OIT) in the Treatment of Cow's Milk Allergy (CMA): Safety of Dosing Jennifer S. Kim, MD Dupilumab Monotherapy in Adults with Moderate-to-Severe Atopic Dermatitis: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Study Thomas R.M. Bieber, MD PhD FAAAAI

Upon completion of this session, participants should be able to discuss recent research developments in the field of allergy/immunology.

80

Allied Health Session

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fee required

included in the Virtual Annual Meeting

TUESDAY, MARCH 4 Panel Discussion Workshop

Q & A Workshop

5801 Improving Inpatient Asthma Outcomes in Pediatrics

5804 Challenges and Interventions to Improve Adherence in Urban Minority Populations with Asthma

3:30 to 4:45 pm Convention Center, Upper Level, Room 5AB Credit: 1.25 CME / 1.50 CE Moderator: Miles M. Weinberger, MD FAAAAI Panelists: Amal H. Assa’ad, MD FAAAAI Karen M. McDowell, MD Joseph D. Spahn, MD

3:30

Upon completion of this session, participants should be able to: Utilize questionnaires that identify need in inpatient asthma care; Identify opportunities to improve outcomes for children with recurrent asthma admissions.

3:45

Panel Discussion Workshop 5802 The Ins and Outs of Managing Dietary and Corticosteroid Therapy in Eosinophilic Esophagitis

4:00

4:15

3:30 to 4:45 pm Convention Center, Upper Level, Room 4 Credit: 1.25 CME / 1.50 CE Moderator: Cynthia S. Rand, PhD Brief-Interval Telephone Surveys of Medication Adherence and Asthma Symptoms In the Chilhood Asthma Management Program Continuation Study Bruce G. Bender, PhD FAAAAI Problem Solving to Improve Adherence and Asthma Outcomes in Urban Adults with Asthma Andrea J. Apter, MD MA MSc FAAAAI Use of Mobile Technology to Improve Adherence in Low-Income Minority Adolescents with Asthma Giselle Mosnaim, MD MS FAAAAI Question & Answer

Upon completion of this session, participants should be able to: Discuss barriers to adherence in urban minority populations with asthma; Discuss the efficacy of a problem solving intervention to improve adherence in urban adults with asthma; Evaluate the efficacy of an MP3 player and peer support intervention to improve adherence in urban minority adolescents with asthma.

3:30 to 4:45 pm Convention Center, Upper Level, Room 2 Credit: 1.25 CME / 1.50 CE Moderator: Dan Atkins, MD FAAAAI Panelists: Juan Pablo Abonia, MD Seema Sharma Aceves, MD PhD FAAAAI Katrinia Jane Allen, MD PhD FAAAAI

Q & A Workshop

Upon completion of this session, participants should be able to: Identify and discuss issues in the dietary treatment and management of EoE, including the use of an elimination diet and how to reintroduce foods into the diet; Identify and discuss issues in the use of swallowed topical steroids in the treatment of EoE.

Problem-Based Learning Workshop 5803 Evaluation and Management of Patients with Recurrent Infections 3:30 to 4:45 pm Convention Center, Upper Level, Room 3 Pre-registration and ticket required. Fee: $50. Credit: 1.25 CME / 1.50 CE PBL Facilitator: Vincent R. Bonagura, MD FAAAAI Content Lecturer: Mark R. Stein, MD FAAAAI

5805 Allergic Inflammation: New Insights into Key Innate Mediators

3:30 3:45 4:00 4:15

Upon completion of this session, participants should be able to: List the susceptibility factors for recurrent infection (immunodeficiency, rhinitis, structural defects, CF); Discuss the role of the diagnostic modalities relevant to the evaluation of patients with recurrent infection; Outline IgG therapy for immunodeficiency patients.

3:30 to 4:45 pm Convention Center, Upper Level, Room 1AB Credit: 1.25 CME / 1.50 CE Moderator: Steve N. Georas, MD IL33 Dependent Allergic Inflammation via FcgRIII Signalling Anne Sperling, PhD Epithelial Cell-Derived Exosomes in Allergic Airway Inflammation Nirav Bhakta, MD PhD Innate Type 2 Cytokines and their Receptors in Human Asthma Morris Ling, MD Question & Answer

Upon completion of this session, participants should be able to: Explain the importance of type 2 innate lymphoid cells in mediating the initial steps of allergic inflammation; Review the importance of airway epithelial cells and the effect of stress on production of inflammatory exosomes in allergic airway inflammation; Recognize the importance of innate type 2 cytokines and their receptors in human asthma.

Annual Meeting Workshops Programmed by the AAAAI. Annual Meeting Workshops funded through an educational grant from Merck.

Allied Health Session

ticket required

fee required

included in the Virtual Annual Meeting

81

TUESDAY, MARCH 4 Year-in-Review Workshop

Q & A Workshop

5806 Mechanistic Basis of Food Allergy: New Frontiers

5808 Follicular Helper T Cells in Health and Disease

3:30

3:45

4:00 4:15

3:30 to 4:45 pm Convention Center, Upper Level, Room 11AB Credit: 1.25 CME / 1.50 CE Moderator: Kari C. Nadeau, MD PhD FAAAAI Environmental Sanitizers as a Potential Cause of Epidemic Food Allergy Jessica R. Savage, MD Novel iNKT Ligands in Foods: Potential Role in the Development of Allergy Patrick J. Brennan, MD PhD Role of B Cells in Food Allergy Therapy Duane R. Wesemann, MD PhD Question & Answer

Upon completion of this session, participants should be able to: Identify the possible role of sanitizing agents in the pathogenesis of food allergy; Review the importance of innate iNKT cell ligands in food allergy; List the principle of B cell receptor editing in the periphery and its potential relevance to the control of IgE responses.

3:30 3:45 4:00 4:15

3:30 to 4:45 pm Convention Center, Mezzanine Level, Room 16AB Credit: 1.25 CME / 1.50 CE Moderator: John W. Steinke, PhD FAAAAI Development of Follicular Helper T Cells Shane Crotty, PhD Vaccines and Follicular Helper T Cells Michael G. McHeyzer-Williams, PhD The Role of Follicular Helper T Cells in Autoimmunity Eric Meffre, PhD Question & Answer

Upon completion of this session, participants should be able to: Discuss how follicular helper T cells develop; Describe how vaccines can be used to modulate follicular helper T cell function; Describe the mechanisms through which follicular helper T cells participate in the development of autoimmunity.

Problem-Based Learning Workshop 5809 A Case of Chronic Severe Urticaria

Panel Discussion Workshop

3:30 to 4:45 pm Convention Center, Upper Level, Room 31C Pre-registration and ticket required. Fee: $50. Credit: 1.25 CME / 1.50 CE PBL Facilitator: Don A. Bukstein, MD Content Lecturer: Allen P. Kaplan, MD FAAAAI

5807 Rapid Desensitizations: Protocols and Management of Reactions 3:30 to 4:45 pm Convention Center, Mezzanine Level, Room 15AB Credit: 1.25 CME / 1.50 CE Moderator: Karen S. Hsu Blatman, MD David E. Sloane, MD Timothy J. Sullivan, MD Katharine M. Woessner, MD FAAAAI

Upon completion of this session, participants should be able to: Discuss the differential diagnosis of a patient with chronic severe urticaria; Debate the evaluation of urticaria, including serological, prick skin testing and biopsy interpretation; Discuss novel medical and immunomodulatory therapy.

Upon completion of this session, participants should be able to: Identify the safety and efficacy of drug desensitization protocols; Discuss the build up and progression of the available protocols for desensitization; Describe management tools for reactions during drug desensitizations.

Annual Meeting Workshops Programmed by the AAAAI. Annual Meeting Workshops funded through an educational grant from Merck.

82

Allied Health Session

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fee required

included in the Virtual Annual Meeting

Scientific Abstract Sessions Asthma Therapeutics: Advances in Biologics and Drugs 2201 Saturday, March 1st, 2014, 9:45 AM - 10:45 AM 1

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A Rare Presentation Of Surfactant Deficiency In a Term Neonate Dr. Nisha N. Shah, MD, LSU Health Sciences Center New Orleans, New Orleans, LA, Dr. Heena Shah, MD, Louisiana State University, New Orleans, LA and Dr. Kenneth Paris, MD, MPH, LSU Health Sciences Center, New Orleans, New Orleans, LA Relapse Of Severe Asthma Exacerbations After Cessation Of Omalizumab Treatment – Real Life Data Dr. Izabela R. Kuprys-Lipinska, MD, PhD and Prof. Piotr Kuna, MD, PhD, Dept. of Internal Medicine, Asthma and Allergy, Medical University in Lodz, Poland Therapeutic Equivalence Of Budesonide/Formoterol (BUD/ FM) Breath-Actuated Inhaler (BAI) Compared With Bud/FM Pressurized Metered-Dose Inhaler (pMDI) In Adults and Adolescents With Moderate To Severe Asthma Kevin R. Murphy, MD1, Rajiv Dhand, MD2, Frank Trudo, MD3, Tom Uryniak, MS3 and Ajay Aggarwal, MD3, 1Boys Town National Research Hospital, Boys Town, NE, 2Department of Medicine, University of Tennessee Graduate School of Medicine, 3 AstraZeneca LP Effects of Budesonide/Formoterol (BUD/FM) Deliverd By Pressurized Metered-Dose Inhaler (pMDI) on Symptoms In African Americans and Caucasians With Moderate and Severe Asthma With and Without Fixed Airway Obstruction (FAO) Donald P. Tashkin, MD, David Geffen School of Medicine at UCLA, Los Angeles, CA, Bradley E. Chipps, MD, Capital Allergy & Respiratory Disease Center, Sacramento, CA and Frank Trudo, MD, AstraZeneca, Wilmington, DE Long-Term Effectiveness Of Omalizumab Treatment In Thai Severe Asthmatic Patients: A Real-Life Experience Dr. Orapan Poachanukoon, MD, Thammasat University, Pathumtani, Thailand, Dr. Theerasak Kawamatawong, Ramathibodi Hospaital, Mahidol University, Taiwan, Dr. Atik Saengasapaviriya, Phramonkutklao hospital, Thailand, Dr. Chanchai Sittipunt, Chulalongkorn University, Thailand, Dr. Hiroshi Chantaphakul, MD, FAAAAI, Chutuchak District, Chulalongkorn University Hospital, Bangkok, Thailand, Prof. Kittipong Maneechotesuwan, Siriraj hospital, Mahidol university, Bangkok, Thailand, Dr. Pintip Ngamchanyaporn, Ramathibodi Hospital, Mahidol University, Thailand, Dr. Kunchit Piyavechviratana, Pramongkut Hospital, Sathorn, Thailand, Dr. Apichart Khanisap, Thammasat University Hospital, Thailand, Dr. Siwasak Juthong, Faculty of Medicine, Songklanakrin University, Thailand, Dr. Warangkana Rithirak, Songklanakarind University, Thailand, Dr. Chaicharn Pothirat, Chiangmai University, Thailand and Dr. Watchara Boonsawat, Srinagarind Hospital, Thailand Role Of Monoclonal Antibody In Sickle Cell Disease Patients With Allergic Rhinitis and Asthma Along With Raised IgE Level Dr. Abdul Rehman Syed, MD, King Fahad University Hospital Khobar, Dammam, Saudi Arabia Effects Of Long-Term Treatment With Budesonide/Formoterol (BUD/FM) Delivered By Pressurized Metered-Dose Inhaler (pMDI) On Symptoms In African-American and Caucasian

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Patients With Moderate To Severe Asthma With and Without Fixed Airway Obstruction (FAO) Randall Brown, MD, MPH, Center for Managing Chronic Disease, University of Michigan School of Public Health, Bradley E. Chipps, MD, Capitol Allergy and Respiratory Disease Center, Donald P. Tashkin, MD, David Geffen School of Medicine at UCLA, Los Angeles, CA and Frank Trudo, MD, AstraZeneca, Wilmington, DE Retrospective Observational Assessment Of Nasal Polyposis In Asthmatic Patients Treated With Omalizumab Dr. Ana Anton-Laiseca, MD, Dr. Silvia Martınez Blanco, MD, Dr. Gabriel Gonzalez Salazar, MD, Dr. Maria Carmen Dieguez Pastor, MD, Dr. Ruth Mielgo Ballesteros, MD and Dr. Consuelo Fernandez Rodrıguez, MD, PhD, Hospital Universitario 12 de Octubre, Spain FDA Guidance-Designed Study Of The Effects Of Intranasal Triamcinolone Acetonide Aqueous (TAA-AQ) On Growth Velocity (GV) Of Children With Perennial Allergic Rhinitis (PAR) Dr. David P. Skoner, MD, Temple University School of Medicine, Allegheny General Hospital, Pittsburgh, PA; West Penn Allegheny Health System, Pittsburgh, PA Extended Omalizumab Dosage Intervals and Efficacy Dr. Saraleen Benouni, MD1, Dr. Lee E. Sheinkopf, MD, FAAAAI2, Dr. LanAnh T. Do, MD, FAAAAI3, Dr. Asif Rafi, MD2 and Dr. Roger M. Katz, MD, FAAAAI2, 1UCLA, Los Angeles, CA, 2ucla, los angeles, CA, 3ucla, Los Angeles, CA Effect Of Roflumilast On Asthma Control In Moderate and Severe Asthma Patients Prof. V.A. Beloglazov1, Dr. Yuri Popenko1 and Prof. Lawrence M. DuBuske, MD, FAAAAI2, 1Crimean State Medical University, Ukraine, 2George Washington University School of Medicine, DC The Potent and Selective CRTH2 Antagonist OC000459 Is Effective In The Treatment Of Eosinophilic Asthma When Given Once Daily Dr. Roy Pettipher1, Dr. Michael Perkins1, Dr. Lisa Pearce Collins1, Dr. Mark Baillet2, Dr. Trevor Lewis3, Dr. Jan Steiner4, Prof. John Bell5, Dr. Mark Payton1 and Dr. Michael Hunter1, 1Atopix Therapeutics, Abingdon, United Kingdom, 2S-Cubed, Abingdon, United Kingdom, 3TL-Wise Consulting, Cambridge, United Kingdom, 4 Oxford Therapeutics Consulting, Brightwell-cum-Sotwell, United Kingdom, 5Medical Sciences Division, Oxford, United Kingdom Safety and Efficacy Of ARRY-502, a Potent, Selective, Oral CRTh2 Antagonist, In Patients With Mild To Moderate Th2Driven Asthma Sally E. Wenzel, MD, FAAAAI1, Robert Hopkins, Director of Clinical Operations2, Dr. Michael Saunders, MD, Senior Director of Drug Safety2, David Chantry, Senior Director of Translational Medicine and Cell Biology2, Lisa Anderson, Clinical Research Manager2, Roger Aitchison, Senior BioStatistician2, Christine Eberhardt, Research Investigator2, Stacie Bell, Director of Clinical Pharmacology2, Dr. Jeremy Cole, MD, Principal Investigator3, Dr. James Wolfe, MD, Physician/Research Investigator4, Dr. Sheldon L. Spector, MD, FAAAAI5, Dr. Lawrence D. Sher, MD, FAAAAI6, Dr. Edward M. Kerwin, MD, FAAAAI7 and Dr. Larry Burgess, PhD, Executive Director of Medicinal Chemistry2, 1University of Pittsburgh Medical Center NW, Pittsburgh, PA, 2Array BioPharma Inc., Boulder, CO, 3IPS Research Company, Oklahoma City, OK, 4 Allergy & Asthma Associates of Santa Clara County Research Center, San Jose, CA, 5California Allergy & Asthma Medical Group, Los Angeles, CA, 6Peninsula Research Associates, Rolling Hills Estates, CA, 7Allergy and Asthma Center of Southern OR, Medford, OR

SATURDAY

Abstracts AB293

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

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AB294 Abstracts

SATURDAY

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J ALLERGY CLIN IMMUNOL FEBRUARY 2014

A Phase I Assessment Of Safety and Tolerability Of RNS60, a Novel Therapeutic Containing Charge-Stabilized Nanostructures In Asthma Supurna Ghosh, PhD, Andreas Kalmes, PhD, Jarrad Mock, Jocelyn Sutherland and Richard Watson, MD, Revalesio Corporation, WA Tiotropium Respimat Add-On To Inhaled Corticosteroids Improves Lung Function In Patients With Symptomatic Mild Asthma: Results From A Phase III Trial Pierluigi Paggiaro1, Dr. David M.G. Halpin, MD2, Roland Buhl3, Dr. Michael Engel, MD4, Valentina Zubek5, Zuzana Blahova6, Dr. Petra Moroni-Zentgraf4 and Dr. Emilio Pizzichini7, 1University of Pisa, Pisa, Italy, 2Royal Devon & Exeter Hospital, Exeter, United Kingdom, 3Mainz University Hospital, Mainz, Germany, 4Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim Am Rhein, Germany, 5Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, 6Boehringer Ingelheim RCV GmbH & Co. KG, Vienna, Austria, 7NUPAIVA (Asthma Research Centre), Universidade Federal de Santa Catarina, Florianopolis, Brazil Tiotropium Respimat Add-On Therapy Reduces Airflow Obstruction In Patients With Symptomatic Moderate Asthma, Independent Of TH2 Inflammatory Status Dr. Thomas B. Casale, MD, FAAAAI1, Dr. Eric Donn Bateman, MD2, Prof. Ronald Dahl, MD3, Dr. Emilio Pizzichini4, Dr. Mark L. Vandewalker, MD5, Dr. Johann Christian Virchow6, Dr. Michael Engel, MD7, Dr. Petra Moroni-Zentgraf7, Dr. Hendrik Schmidt8 and Huib A.M. Kerstjens9, 1Univeristy Of South Florida Morsani College Of Medicine, Tampa, FL, 2University of Cape Town Lung Institute, Cape Town, South Africa, 3Odense University Hospital, Odense, Denmark, 4NUPAIVA (Asthma Research Centre), Universidade Federal de Santa Catarina, Florianopolis, Brazil, 5Clinical Research of the Ozarks, Columbia, MO, 6University Clinic Rostock, Rostock, Germany, 7Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim Am Rhein, Germany, 8Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany, 9University Medical Center Groningen, University of Groningen, Groningen, Netherlands Once-Daily Tiotropium Respimat Improves Lung Function In Patients With Severe Symptomatic Asthma Independent Of Leukotriene Modifier Use Prof. Ronald Dahl, MD1, Prof. Dennis E. Doherty2, Jonathan Corren, MD3, Dr. Jill Karpel4, Huib A. M. Kerstjens5, Dr. Michael Engel, MD6, Dr. Petra Moroni-Zentgraf6, Dr. Hendrik Schmidt7 and Dr. Shu Hashimoto, MD, PhD8, 1Odense University Hospital, Odense, Denmark, 2Lexington VA Medical Center, University of Kentucky, Lexington, KY, 3University of California, Los Angeles, CA, 4North Shore Medical Arts LLP, Great Neck, NY, 5University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 6Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim Am Rhein, Germany, 7Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany, 8Nihon University School of Medicine, Tokyo, Japan

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Test-Retest Reliability Of The ISAAC Questionnaire For a Web-Based Study Dr. Koichi Yoshida, MD1, Dr. Yuichi Adachi, MD, PhD2, Dr. Mari Sasaki, MD1, Dr. Mayumi Furukawa, MD1, Dr. Toshiko Itazawa, MD, PhD2, Dr. Koji Hashimoto, MD, PhD3, Dr. Hiroshi Odajima4 and Dr. Akira Akasawa, MD, PhD1, 1Division of Allergy, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan, 2Department of Pediatrics, University of Toyama, Toyama, Japan, 3Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan, 4Fukuoka National Hospital, Fukuoka, Japan Characteristics Of Adolescents With Undiagnosed Asthma In Rural Counties In Georgia Dr. Poneh Davoodi, MD1, Dr. Dennis Ownby, M.D. FAAAAI2, Ms. Suzanne Havstad, M.A.3, Dr. Jennifer Waller, PhD4, Dr. Christine L.M. Joseph, PhD3 and Dr. Martha Tingen, PhD4, 1Georgia Regents University, 2Division of Allergy-Immunology and Rheumatology, Georgia Regents University, Augusta, GA, 3Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, 4 Georgia Regents University, Augusta, GA Trends In Prevalence Of Asthma and Allergies In 13-14 Year Old Children Between Two ISAAC Studies In Birjand City, Iran Dr. Mohammad Fereidouni, MD, PhD, Asthma, Allergy & Immunology Research Center,Birjand University of Medical Sciences, Iran and Mrs. Shaghayeghsadat Nourani hassankiadeh, birjand university of medical sciences An Evaluation Of The Thai-Translated Version Of The Childhood Asthma Control Questionnaire (C- ACT) and The Composite Asthma Severity Index (CASI) Among Thai Asthmatic Children Dr. Benjarat Dardaranonda, MD, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, THAILAND, Bangkok, Thailand Impact Of Change In Inhaled Corticosteroids/Long-Acting Beta Agonist Combination (ICS/LABA) Use On The Risk Of Asthma Exacerbations In Asthma Patients Within a Medical Group Dr. Richard H. Stanford, PharmD, MS1, Saurabh Nagar, MS1, Dr. Xiwu Lin, PhD1 and Dr. Dick O’Connor, MD2, 1 GlaxoSmithKline, 2Sharp Rees-Stealy Medical Group, San Diego, CA HLA-DRB1 Alleles, Levels Of Total IgE and IL-13 In Patients Of Bronchial Asthma From A Local Tertiary Care Hospital In Lahore, Pakistan Mr. Khursheed Javaid, M.Phil., University of Health Sciences, Lahore, Pakistan Infectious Asthma Trigger, Acq Score and Minirqlq Score Correlations Support The One Airway Hypothesis Dr. Amy Virojanapa, MD1, Ms. Phoebe Shah2, Mr. Arthur Omondi1 and Dr. Efren L. Rael, MD, FAAAAI3, 1Penn State, Hershey Medical Center, Hershey, PA, 2UC San Diego, Vista, CA, 3Allergy/Immunology, Penn State University College of Medicine, Hershey, PA

Asthma Epidemiology 2202 Saturday, March 1st, 2014, 9:45 AM - 10:45 AM 18

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Close Correlation Between Month Of Birth and The Prevalence Of Bronchial Asthma In Schoolchildren In a Taiwanese Population Prof. Ho-Chang Kuo, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, Kaohsiung, Taiwan, Prof. Wei-Chiao Chang, Taipei Medical University, Prof. Kuender D. Yang, Show Chwan Memorial Hospital in Chang Bing, Changhua, Taiwan and Prof. Wei-Pin Chang, Yuanpei University, Taiwan

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Comprehensive Immunological and Clinical Features Of Common Variable Immunodeficiency (CVID) Dr. Varaz Bozoghlanian, MD1, Sudhanshu Agrawal, MS2 and Sudhir Gupta, MD, PhD, FAAAAI1, 1University of California, Irvine, Irvine, CA, 2University of California, Irvine

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Clinical, Immunological and Genetic Spectrum Of Novel BTK Gene Mutations In X-Linked Agammaglobulinemia Patients and Female Carriers Dr. Regan Pyle, DO1, Dr. John B. Hagan, MD, FAAAAI1, Amanda Martinez, MS1, Dr. Avni Y. Joshi, MD1, Dr. Thomas Boyce, MD1, Dr. Gerald W. Volcheck, MD, FAAAAI2, Dr. Yesim Yilmaz-Demirdag, MD3, Prof. Sami L. Bahna, MD DrPH FAAAAI4 and Dr. Roshini S. Abraham, PhD FAAAAI1, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic and Foundation, Rochester, MN, 3Columbia University, New York, NY, 4 LA State University Health Sciences Center, Shreveport, LA CD19+CD27+CD43+CD70-CD5- B-1b Cells In Children With Specific Antibody Deficiency, Specific Antibody Deficiency With Decreased IgG, and Common Variable Immunodeficiency Dr. Kathryn D. Convers, MD1,2, Barbara Kariuki, MPH1 and Dr. Alan Knutsen, MD, FAAAAI1,2, 1Saint Louis University School of Medicine, Saint Louis, MO, 2Cardinal Glennon Children’s Medical Center, Saint Louis, MO A Devastating Outcome In Undiagnosed X-Linked Agammaglobulinemia— A Call For Earlier Screening Dr. Karen Elizaeth Bruner, MD, Wilford Hall Ambulatory Surgical Center, Lackland AFB, TX and Dr. Anthony Infante, MD, PhD, UT Health Science Center San Antonio, San Antonio, TX Genetic Basis Of CVID-Like Disease Dr. Kate Welch, MD, Mt. Sinai Medical Center, Dr. Elena Resnick, MD, Mount Sinai School of Medicine, New York, NY and Dr. Charlotte Cunningham-Rundles, MD, PhD, FAAAAI, Mt. Sinai Medical Center, New York, NY A Case Of A CVID Patient and Rabies Exposure Dr. Hassan Nasir, DO, Nova Southeastern University College of Osteopathic Medicine, Davie, FL; Larkin Community Hospital, Miami, FL and Dr. Shahnaz Fatteh, Larkin Community Hospital, South Miami, FL Common Variable Immunodeficiency In The Very Old Dr. Katherine E. Gundling, MD, UCSF, San Francisco, CA Clinical Predictors Of Granulomatous Disease In Common Variable Immunodeficiency Dr. Anna R. Wolfson and Dr. Anna Kovalszki, Beth Israel Deaconess Medical Center, Boston, MA Jacobsen Syndrome With Combined Variable Immunoddeficiency (CIVD) Dr. Arnaldo C. Porto Neto, MD, PhD, FAAAAI, Dr. Julio Mella Pierezan, Student, Dr. Joao Paulo Bordin, Student, Dr. Julia Noschang, Dr. Juliana Gotardo, Student, Dr. Juliana Moro, Student, Dr. Jorge Luigi Orso, Student, Dr. Jamile Pedroni, Student and Dr. Jessica Zandona, Student, School of Medicine UPF, PASSO FUNDO, Brazil Factors Predicting Long-Term Hypogammaglobulinemia In Lymphoma Survivors Dr. Huifang Lu, MD, PhD, UT MD Anderson Cancer Center, Houston, TX and Dr. Xerxes Pundole, UT MD Anderson Cancer Center Assessment Of Benefits Of Scig Valued By Healthcare Providers and Patients: Survey Results Ms. Annette R. Zampelli, NP1, Ms. Carla M. Duff, CPNP MSN2 and Dr. Ann Bullinger, PharmD1, 1CSL Behring, LLC, King of Prussia, PA, 2University of South Florida, Tampa, FL Pneumococcal Titer Levels: Comparison Of Patients Receiving Intravenous Immunoglobulin Vs. Subcutaneous Immunoglobulin Dr. Pamella Abghari, MD1,2, Dr. Elizabeth A. Secord, MD, FAAAAI1,2 and Dr. Pavadee Poowuttikul, MD1,3, 1Children’s Hospital of Michigan Department of Allergy Immunology, Detroit, MI, 2Wayne State University, Detroit, MI, 3Pediatrics- Allergy/Immunology Division, Wayne State University School of Medicine, Detroit, MI Hypogammaglobulinemia, Multiple Sclerosis, and Treatment With Intravenous Gammaglobulin Dr. Tiffany Dy, MD, Montefiore Medical Center at Albert Einstein College of Medicine, Bronx, NY and Dr. Arye

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Rubinstein, MD, FAAAAI, Albert Einstein College of Medicine, Bronx, NY Selective IgM Deficiency Presenting As Cryptogenic Organizing Pneumonia Dr. Cory A. Lundberg, DO1, Dr. Taylor A. Banks, MD1, Dr. Cecilia Mikita, MD, MPH FAAAAI2 and Dr. Jeffrey Mikita, MD1, 1 Walter Reed National Military Medical Center, Bethesda, MD, 2 Walter Reed Army Medical Center, Bethesda, MD High Prevalence Of Bronchiolitis In Children With Primary Immunodeficies Dr. Celia Pinto Fernandez1, Dr. Marıa Dolores Gurbindo Gutierrez1, Dr. Jose Manuel Zubeldia Ortuno, MD, PhD2 and Dr. Marıa non Universitary Hospital, Elena Seoane Reula1, 1Gregorio Mara~ Madrid, Spain, 2Hospital Gregorio Maranon, Madrid, Spain Three Cases Of Good’s Syndrome Dr. Whitney M. Rassbach, MD, Mount Sinai School of Medicine, New York, NY and Dr. Charlotte Cunningham-Rundles, MD, PhD, FAAAAI, Mt. Sinai Medical Center, New York, NY Immunological Analysis Of Primary Selective IgM Deficiency In Adults Ankmalika Louis, MD, UNIVERSITY OF CALIFORNIA, IRVINE, CA, Sudhanshu Agrawal, MS, University of California, Irvine and Sudhir Gupta, MD, UNIVERSITY OF CALIFORNIA, IRVINE A Rare Case Of Helicobacter Cellulitis In a Patient With XLinked Agammaglobulinemia Dr. Nina Lakhani, MD1, Dr. Linda R. Taggart2, Dr. Henry Jakubovic3, Dr. Stephen D. Betschel, MD1 and Dr. Zafir Hussain4, 1 University of Toronto, Division of Clinical Immunology and Allergy, Toronto, ON, Canada, 2University of Toronto, Divison of Infectious Diseases, Toronto, 3University of Toronto, Division of Laboratory Medicine and Pathology, Toronto, ON, Canada, 4 University of Toronto, Division of Microbiology, Toronto, ON, Canada Neuropathy In Patients With Underlying Immunodeficiency Syndrome Dr. Robyn Kreiner, MD and Dr. Arye Rubinstein, MD, FAAAAI, Albert Einstein College of Medicine, Bronx, NY

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Abstracts AB295

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

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Allergic Sensitization and Enviromental Exposures In Amish and Hutterite Children Dr. Mark Holbreich, MD, FAAAAI1, Ms. Michelle Stein, MS2, Ms. Rebecca Anderson, MS3, Dr. Nervana Metwali, PhD4, Dr. Peter S. Thorne, PhD4, Dr. Donata Vercelli, MD5, Dr. Erika Von Mutius, MD, MSc6 and Dr. Carole Ober, PhD3, 1Allergy and Asthma Consultants, Indianapolis, IN, 2The University of Chicago, Chicago, IL, 3University of Chicago, Chicago, IL, 4 University of Iowa, Iowa City, IA, 5The University of Arizona, Tucson, AZ, 6University Children’s Hospital, Munich, Germany Association Between Asthma-Related Emergency Department Visits, Tree Pollen, Pollution and Humidity In The Bronx, 2001 - 2008 Dr. Jennifer Toh, MD1, Dr. Mili Shum, MD2,3, Dr. Gabriele De Vos, MD4, Tulsi Desai4, Priyank Patel4, Dr. Sunit Jariwala, MD1 and Dr. David L. Rosenstreich, MD, FAAAAI5, 1Albert Einstein/ Montefiore Medical Center, New York, NY, 2Montefiore Medical Center, Bronx, NY, 3Weill Cornell Medical College, New York,

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NY, 4Albert Einstein College of Medicine, Bronx, NY, 5Albert Einstein/Montefiore Medical Center, Bronx, NY Association Of Wheezing Illness With Respiratory Viruses In Hospitalized Jordanian Children Olajumoke Fadugba, MD1, Eva Kathryn Miller, MD2, Najwa Khuri-Bulos, MD, FIDSA, CIC3, Samir Faouri, MD3, Asem Shehabi, PhD4, Christopher Fonnesbeck, PhD1, Li Wang, MS1, John V. Williams, MD1 and Natasha Halasa, MD, MPH1, 1Vanderbilt University Medical Center, Nashville, TN, 2Pediatric Allergy, Immunology, and Pulmonary Medicine, Vanderbilt University Medical Center, Nashville, TN, 3Jordan University Hospital, Jordan, 4 University of Jordan, Jordan The Effect Of Obesity On Asthma Control As Measured By The Asthma Control Test Dr. Aerik A. Williams, MD, MPH1, Dr. Mark S. Dykewicz, MD, FAAAAI2 and Dr. Jason W. Caldwell, DO, FAAAAI1, 1Wake Forest University Baptist Medical Center, Winston Salem, NC, 2Saint Louis University School of Medicine, St. Louis, MO Perception Of Asthma Control Is Not Consistent With Reported Symptom Frequency In Urban Adolescents Emily C. Ledford, Johns Hopkins School of Medicine, Ms. Jean Curtin-Brosnan, MA, Johns Hopkins University, Baltimore, MD, Dr. Meredith C. McCormack, MD, The Johns Hopkins Pulmonary, Baltimore, MD and Dr. Elizabeth Matsui, MD, The Johns Hopkins University School of Medicine, Baltimore, MD Urban Residence Modifies The Association Between Atopy and Wheeze Dr. Pablo F. Endara1, Dr. Phil J. Cooper2,3, Thomas A.E. PlattsMills, MD, PhD, FAAAAI4, Lisa J. Workman, BA4, Maritza Vaca5, Dr. Martha Chico6, Mauricio L Barreto, PhD7 and Prof. Laura Rodrigues8, 1Universidad San Francisco de Quito, 2St. George’s University, London, United Kingdom, 3Pontificia Universidad Catolica del Ecuador, 4Division of Asthma, Allergy & Immunology, University of Virginia Health System, Charlottesville, VA, 5 Laboratorio de FEPIS, Quininde, Esmeraldas Province, Ecuador, 6 Laboratorio de Investigacion FEPIS, 7Instituto de Saude Coletiva, UFBa, Salvador, BA, Brazil, 8London School of Hygiene and Tropical Medicine Allergic Inflammation and Health Outcomes Of Comorbid Asthma and Obesity In Inner-City Black and Hispanic Schoolchildren Dr. Perdita Permaul, MD1,2, Dr. William J. Sheehan, MD2,3, Mr. Carter Petty, MA3, Dr. Sachin N. Baxi, MD2,3, Dr. Jonathan M. Gaffin, MD, MMSc2,3, Dr. Lianne S. Kopel, MD2,3, Dr. Watcharoot Kanchongkittiphon, MD, PhD3, Mrs. Chunxia Fu, MS4, Dr. Diane R. Gold, MD, MPH2,4 and Dr. Wanda Phipatanakul, MD, MS, FAAAAI2,3, 1Division of Pediatric Allergy/Immunology, Massachusetts General Hospital, Boston, MA, 2Harvard Medical School, Boston, MA, 3Boston Children’s Hospital, Boston, MA, 4Channing Laboratory, Brigham and Women’s Hospital, Boston, MA Targeted Education Of Adult Patients From An Inner City Population At Risk For Non-Adherence With Asthma Therapy Dr. Edan Sarid, MD, SUNY Downstate Medical Center, Center for Allergy and Asthma Research, Brooklyn, NY and Dr. Rauno Joks, MD, Center for Allergy and Asthma Research at SUNY Downstate, Brooklyn, NY Maternal Allergy and Asthma and Their Association With Breastfeeding In Inner-City Mothers In a Birth Cohort Study (URECA) Katy F. Jaffee, MS1, Dr. Cynthia Visness, PhD1, Dr. George T. O’Connor, MD2, Dr. Gordon R. Bloomberg, MD, FAAAAI3, Dr. Meyer Kattan, MD4, Robert A. Wood, MD, FAAAAI5, Dr. Peter J. Gergen, MD, MPH6 and Dr. James E. Gern, MD, FAAAAI7, 1 Rho, Inc., Chapel Hill, NC, 2Boston University School of Medicine, Boston, MA, 3Campus Box 8116, St. Louis Children’s Hospital, Saint Louis, MO, 4NewYork-Presbyterian/Columbia, New York, NY, 5Johns Hopkins University Medical Center, Baltimore,

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MD, 6AAIB\DAIT\NIH, Bethesda, MD, 7University of Wisconsin School of Medicine and Public Health, Madison, WI Genetic Determinants Of Allergic Sensitization To Cockroach Allergen In Children Priya Tripathi, PhD1, Xiumei Hong, PhD2, Deanna Caruso, MS2, Peisong Gao, MD, PhD1 and Dr. Xiaobin Wang, MD, MPH ScD2, 1 Division of Allergy & Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Johns Hopkins University School of Public Health, Baltimore, MD Exhaled Nitric Oxide (FeNO) and Dust Mite (Der p1) Exposure Are Significantly Higher In Asthmatic Children Living In Humid Environments Dr. Miguel J. Lanz, MD, FAAAAI1, Benjamin Efaw2, Mirna Gonzalez1 and Dr. Ronald J. Harbeck, PhD2, 1AAADRS Clinical Research Center, Coral Gables, FL, 2National Jewish Health, Denver, CO

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Extraordinary Alternaria Mold Counts During a Severe Drought Mr. James J. Anderson, MLT, Environmental Allergy/Oshtech, London, ON, Canada and Dr. Linda B. Ford, MD, FAAAAI, The Asthma & Allergy Center, P.C., Bellevue, NE Culture Of The House Dust Mite Euroglyphus Maynei To Produce Allergen Material Dr. Larry G. Arlian, PhD FAAAAI, DiAnn L. Vyszenski-Moher, MS, Dr. Marjorie S. Morgan, PhD and Jacqueline Neal, MS, Wright State University, Dayton, OH Emergency Department Visits For Asthma As a Function Of Pollen and Mold Spore Counts Dr. Stacey Galowitz, DO1,2, Dr. Christopher Chang, MD, PhD, FAAAAI1 and Mr. Michael R. McDowell3, 1Alfred I duPont Hospital for Children, Wilmington, DE, 2Thomas Jefferson University Hospital, Philadelphia, PA, 3Air Quality Management, New Castle, DE Daily Ragweed Pollen Forecasting Estelle Levetin, PhD FAAAAI1 and Lauren Howard, B.S.1,2, 1University of Tulsa, Tulsa, OK, 2University of Oklahoma, Oklahoma City, OK Conditions Affect Dust Mite Infestation Of Flour Samples In Tropical Area Dr. Theerapan Songnuy, Allergy and Immunology Division, Chulalongkorn University Medical School, Bangkok, Thailand Airborne Alternaria Spore Levels In Kansas City Is Associated With Climatic Changes Dr. David A. Jara, MD1, Dr. Charles Barnes, PhD2, Dr. Jay M. Portnoy, MD, FAAAAI2 and Dr. Minati Dhar, Ph.D3, 1Childrens Mercy Hospital, 2Children’s Mercy Hospital, Kansas City, MO, 3 Children’s Mercy Hospital & Clinics, Kansas City, MO Influence Of Meteorological Conditions On Mountain Cedar Pollen Landon Bunderson, PhD1,2, Peter Van De Water, PhD3, Jeffrey Luvall, PhD4 and Estelle Levetin, PhD FAAAAI2, 1Iowa State University, Ames, IA, 2University of Tulsa, Tulsa, OK, 3California State University, Fresno, Fresno, CA, 4NASA Marshall Space Flight Center, Huntsville, AL A Post-Hoc Qualitative Analysis Of Real Time Heads-Up Pollen Counting Versus Traditional Microscopic Counting In The Environmental Exposure Unit (EEU) Ms. Lisa Steacy, BSc1, Mr. Terry Walker, BA1, Mr. Barnaby Hobsbawn1, Mrs. Jenny Thiele, MSc2 and Dr. Anne K. Ellis, MD, MSc FAAAAI1,3, 1Allergy Research Unit, Kingston General Hospital,

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Kingston, ON, Canada, 2Queens University, Kingston, ON, Canada, 3 Departments of Medicine and Biomedical & Molecular Science, Queen’s University, Kingston, ON, Canada Real-Time PCR Quantification Of Virginia Live Oak (Quercus virginiana) Pollen Dr. Mark C. Glaum, MD, PhD, FAAAAI1,2, Ms. Eileen Rifkin1, Dr. Jia-Wang Wang, PhD1, Dr. Richard F. Lockey, MD1,2 and Dr. Dennis K. Ledford, MD, FAAAAI1,2, 1Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida, Morsani College of Medicine, Tampa, FL, 2James A. Haley Veterans’ Affairs Hospital, Tampa, FL Unusual Timing For The Ragweed Ambrosia Pollen Peak In Vinnitsa, Ukraine Ms. Viktoria Rodinkova1, Ms. I Motruk1, Ms. L. Slobodianiuk1, Ms. O. Mazur1, Ms. O. Palamarchuk1 and Prof. Lawrence M. DuBuske, MD, FAAAAI2, 1Vinnitsa National Pirogov Memorial Medical University, Ukraine, 2George Washington University School of Medicine, DC

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Safety and Efficacy Of a 12-Week Maintenance Interval In Patients Treated With Imported Fire Ant Immunotherapy Dr. Karla E. Adams, MD1, Dr. Shayne Stokes, MD2, Dr. Kevin M. White, MD1, Dr. Kirk H. Waibel, MD, FAAAAI3 and Dr. Michael S. Tankersley, MD, FAAAAI4, 1Wilford Hall Ambulatory Surgical Center, Joint Base San Antonio, Lackland AFB, TX, 2 Luke AFB, Glendale, AZ, 3Landstuhl RMC, 4Wilford Hall Ambulatory Surgical Center, Joint Base San Antonio, San Antonio, TX Epidemiology and Clinical Predictors Of Biphasic Reactions In Children With Anaphylaxis Waleed D. Alqurashi1, Ian Stiell2, Kevin Chan3, Gina Neto1 and George Wells4, 1Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada, 2Ottawa Hospital Research Institute, Ottawa, ON, Canada, 3 Hospital for Sick Children, Toronto, ON, Canada, 4University of Ottawa Heart Institute, Ottawa, ON, Canada Age As a Risk Factor For Fatal Food-Induced Anaphylaxis: An Analysis Of UK and Australian Fatal Food Anaphylaxis Data Dr. Paul J. Turner, FRACP PhD1,2, Dr. Vibha Sharma, FRCPCH3, Prof. Mimi L. K. Tang, MD, PhD, FAAAAI4, Ms. M. Hazel Gowland, BA5, Dr. Nigel Harper, MBChB FRCA3, Dr. Tomaz Garcez, MRCP FRCPath3, Dr. Richard Pumphrey, FRCPath3 and Dr. Robert J. Boyle, MBChB PhD1, 1Imperial College London, United Kingdom, 2University of Sydney, Australia, 3Central Manchester University Hospitals NHS Foundation Trust, United Kingdom, 4The University of Melbourne, Melbourne, Australia, 5Allergy Action, United Kingdom Dying From Allergies: A Profile Of Fatal Anaphylaxis In The United States: 1999-2010 Dr. Elina Jerschow, MD, M.Sc.1, Dr. Robert Yao-Wen Lin, FAAAAI2,3, Ms. Moira Scaperotti, Medical Student4 and Dr. Aileen McGinn, PhD4, 1Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, 2New York Downtown Hospital, New York, NY, 3New York Medical College, Valhalla, NY, 4 Albert Einstein College of Medicine, Bronx, NY Prospective Study To Determine Risk Factors and Severity Of Food-Induced Allergic Reactions In Children Dr. Angela Tsuang, MD1, Mr. Nikhil Menon, Medical student1, Ms. Natasha Setia, Medical student1, Mr. Larry Geyman, Medical student1, Ms. Christina Cherny2 and Dr. Anna H. Nowak-Wegrzyn, MD, FAAAAI3, 1Mount Sinai School of Medicine, New York, NY,

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2 Cornell University, 3Icahn School of Medicine at Mount Sinai, New York, NY Factors Associated With Increased Risk Of Anaphylaxis Aylin Altan Riedel, PhD1, Erin Buysman, MS1, Dr. Ray A. Wolf, PharmD2, Paul Cavanaugh, Jr, PhD3, Jerald Seare, MD1 and Tim Bancroft, PhD1, 1OPTUM, Prairie Eden, MN, 2Mylan Specialty L.P., New Hope, PA, 3Mylan Specialty, Basking Ridge, NJ A Face-To-Face Educational Program By Allergists Can Improve Knowledge, Attitudes, and Behaviors (KAB) Of Internal Medicine, Pediatric, and Emergency Medicine Residents Dr. Artemio M. Jongco III, MD, PhD MPH, Feinstein Institute for Medical Research, Manhasset, NY; Cohen Children’s Medical Center of New York, Great Neck, NY, Dr. Sheila Bina, MD, Stony Brook University Hospital, Stony Brook, NY, Dr. Robert Sporter, MD, Division of Allergy/Immunology, Departments of Medicine and Pediatrics, Hofstra North Shore-LIJ School of Medicine, Dr. Marie A. Cavuoto Petrizzo, MD, FAAAAI, ProHealth Care Associates LLP, Lake Success, NY, Dr. Blanka M. Kaplan, MD, FAAAAI, Department of Pediatrics, Division of Allergy & Immunology, Hofstra-North Shore-LIJ School of Medicine, Great Neck, NY and Dr. Susan Schuval, MD, FAAAAI, Stony Brook U Medical Cente, Stony Brook University Medical Center, Stony Brook, NY Anaphylaxis Management Before and After Implementation Of Guidelines In The Pediatric Emergency Department Dr. Shilpa Desai1, Dr. Rhett Lieberman1, Stephen Wisniewski, PhD2 and Dr. Todd David Green, MD, FAAAAI1, 1Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 2University of Pittsburgh Managing Anaphylaxis In Adults: A Review Of All Cases Presenting In A Single Year At An Emergency Department Dr. Yarden Yanishevsky, MD1, Dr. Ann Elaine Clarke, MD, MSc2,3, Dr. Sebastian La Vieille, MD4, Dr. Scott Delaney, MD5, Dr. Reza Alizadehfar, MD1, Mr. Christopher Mill, BSc3, Dr. Lawrence Joseph, PhD3, Dr. Judy Morris, MD, MSc6, Dr. Yuka Asai, MD3,7 and Dr. Moshe Ben-Shoshan, MD, MSc1, 1Division of Paediatric Allergy and Clinical Immunology, Department of Paediatrics, McGill University Health Center, Montreal, QC, Canada, 2Division of Allergy and Clinical Immunology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada, 3Division of Clinical Epidemiology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada, 4Food Directorate, Health Canada, Ottawa, ON, Canada, 5Department of Emergency Medicine, McGill University Health Center, Montreal, QC, Canada, 6Department of Emergency Medicine, H^ opital du Sacr!e-Cœur, Montreal, QC, Canada, 7Division of Dermatology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada Anaphylaxis Cases Presenting To Primary Care Paramedics In Quebec Ms. Nofar Kimchi1, Dr. Ann Elaine Clarke, MD, MSc2,3, Jocelyn Moisan4, Colette Lachaine5, Dr. Sebastian La Vieille, MD6, Dr. Yuka Asai, MD3,7, Dr. Lawrence Joseph, PhD3,8, Mr. Christopher Mill, BSc3 and Dr. Moshe Ben-Shoshan, MD, MSc9,10, 1Technion American Medical Students Program, Israel, 2McGill University Health Centre, Montreal, Canada, 3Division of Clinical Epidemiology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada, 4Services pr!ehospitaliers d’urgence de l’Outaouais, Quebec, Canada, QC, Canada, 5Direction adjointe de services pr!ehospitaliers d’urgence, MSSS, Quebec, Canada, QC, Canada, 6Food Directorate, Health Canada, Ottawa, ON, Canada, 7Division of Dermatology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada, 8Departments of Epidemiology and Biostatistics, McGill University, Montreal, Canada, 9Division of Paediatric Allergy and Clinical Immunology, Department of Paediatrics, McGill University Health Center, Montreal, QC, Canada, 10Montreal Children’s Hospital, Montreal, Canada

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Abstracts AB297

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

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Anaphylaxis Management In A Pediatric Emergency Department Natasha Sidhu, MD1,2, Stacie M. Jones, MD3,4, Elizabeth Storm, MD1,2, Maria Melguizo castro1,5, Todd Nick1,2 and Tonya Thompson, MD1,2, 1University of Arkansas for Medical Sciences, Little Rock, AR, 2Arkansas Children’s Hospital, 3University of Arkansas for Medical Sciences and Arkansas Children’s Hospital, Little Rock, AR, 4Arkansas Children’s Hospital Research Institute, Little Rock, AR, 5Arkansas Children’s Hospital, Little Rock, AR Characteristics Of Anaphylaxis In a Pediatric Emergency Unit Beatriz Ameiro, M.D.1, Blanca Noguerado, M.D.1, Gabriela Zambrano, M.D.1, Cristina Morales, M.D.1, Miguel Guzman, M.D.1, Marıa L. Baeza, MD, PhD2 and Alberto Alvarez-Perea, MD3, 1 Hospital General Universitario Gregorio Mara~ non, Allergy Departmen, Madrid, Spain, 2Hospital General Universitario Gregorio Mara~ non, Allergy Department, Madrid, Spain, 3Hospital Materno Infantil Gregorio Mara~ non, Pediatric Allergy Department, Madrid, Spain Characteristics Of Anaphylaxis and Angioedema In Pediatric Emergency Center Dr. Jung Hyun Kwon, Departments of Pediatrics Ewha Womans University School of Medicine, Korea, Seoul, South Korea and Dr. Hyun Sup Keum, Departments of Pediatrics Ewha Womans University School of Medicine, Korea, South Korea Anaphylaxis: Epidemiology and Treatment In The Emergency Department Dr. Judy Morris, MD, MSc1,2, Dr. Julie Lapointe1, Dr. Sebastien La Vieille, MD3, Dr. Harley Eisman, MD4,5, Dr. Reza Alizadehfar, MD6, Ms. Emma Perkins, BSc7, Mr. Christopher Mill, BSc7, Dr. Lawrence Joseph, PhD5,7, Dr. Ann Elaine Clarke, MD, MSc7,8 and Dr. Moshe Ben-Shoshan, MD, MSc5,6, 1Department of Emergency Medicine, H^ opital du Sacre-Cœur, Montreal, QC, Canada, 2 University of Montreal, Montreal, QC, Canada, 3Food Directorate, Health Canada, Ottawa, ON, Canada, 4Montreal Children’s Hospital, Montreal, QC, Canada, 5McGill University, Montreal, QC, Canada, 6Division of Paediatric Allergy and Clinical Immunology, Department of Paediatrics, McGill University Health Center, Montreal, QC, Canada, 7Division of Clinical Epidemiology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada, 8Division of Allergy and Clinical Immunology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada Anaphylaxis In An Upstate New York Emergency Department: Triggers and Treatments Dr. Britta Sundquist, Dr. Jaison Jose, Dr. John Paige, Keith Sweeney, Michael Lavelle, Dr. Daniel Pauze, Dr. Denis Pauze and Dr. Kirsi M. Jarvinen, Albany Medical College, Albany, NY The Clinical Characteristics Of Children and Adolescents With Anaphylaxis Who Visited 139 ERs In Korea In 2012 Dr. Mi-Hee Lee, Department of Pediatrics, Seoul Women’s Hospital, Incheon, South Korea, Dr. Eun-Hee Chung, Department of Pediatrics,National Medical Center, Seoul, South Korea and Dr. Young-Shil Lim, Division of Chronic Disease Surveillance, Korea Centers for Disease Control and Prevention, Osong, South Korea Pattern Of Epinephrine Use and Referral Of Emergency Department Personnel In A Korean Hospital Dr. Jae Won Jeong, Inje University Ilsan PAIK Hospital, Goyangsi, South Korea, Dr. Chansun PARK, Haeunda PAIK Hospital, South Korea and Mi Young KIM, Busan PAIK Hospital, South Korea Characterisation Of Anaphylaxis In a Large UK City With An Ethnically Diverse Population Richard J. Buka1, Richard J. Crossman2, Cathryn Derbridge1, Aarnoud P. Huissoon1, Scott Hackett1, Matthew W. Cooke1,2, Susan Dorrian1 and Mamidipudi T. Krishna1, 1Birmingham Heartlands Hospital, Birmingham, United Kingdom, 2University of Warwick, United Kingdom

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Ten Years’ Experience Of Anaphylaxis In a Single University Hospital In Korea Dr. Cheol-Woo Kim, Inha University Hospital, Incheon, South Korea and Jae Hwa Cho, Inha University Hospital, South Korea Incidence Of Anaphylaxis In a Vilnius Lithuania Hospital Applying WAO Criteria Prof. Audra Blaziene1, Dr. Neringa Buterleviciute1, Viktorija Paltarackiene2 and Prof. Lawrence M. DuBuske, MD, FAAAAI3, 1Vilnius University Medical School, Lithuania, 2Vilnius university Medical School, Lithuania, 3George Washington University School of Medicine, Washington, DC Factors Associated With a Lower Probability Of Refilling An Epipen Auto-Injector In a Timely Manner Erin Buysman, MS1, Dr. Ray A. Wolf, PharmD2, Paul Cavanaugh, Jr, PhD3, Aylin Altan Riedel, PhD1 and Tim Bancroft, PhD1, 1OPTUM, Prairie Eden, MN, 2Mylan Specialty L.P., New Hope, PA, 3 Mylan Specialty, Basking Ridge, NJ Food-Induced Anaphylaxis: Recognition and Response In Ohio Schools Dr. Erica Glancy, MD1, Dr. Peter J. Mustillo, MD, FAAAAI2, Dr. Christine B. Cho, MD3, Dr. Rekha Raveendran, MD4 and Dr. Daniel Scherzer, MD2, 1Cleveland Clinic, Cleveland, OH, 2Nationwide Children’s Hospital, Columbus, OH, 3National Jewish Health, Denver, CO, 4Asthma and Allergy Center LLC, Washington, DC Availability and Utilization Of Epinephrine In Utah Schools For The Management Of Anaphylaxis Benjamin L. Wright, MD1, Michelle Fogg, BS2, Catherine Sparks, MSN, RN, NCSN3, Brian P. Vickery, MD, FAAAAI4, Dr. Joseph L. Roberts, MD, PhD5, Yamini Virkud, MD, MA1 and Mandy Allison, MD, MSPH, M.Ed.6, 1Duke University, Durham, NC, 2Utah Food Allergy Network, Salt Lake City, UT, 3Utah Department of Health, Salt Lake City, UT, 4University of North Carolina, Chapel Hill, NC, 5Duke University Medical Center, Durham, NC, 6University of Colorado Denver, Denver, CO Induction Of Remission Of Frequent Idiopathic Anaphylaxis With Rituximab Dr. Arturo Borzutzky, MD, Division of Pediatrics, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile, Dr. Pamela S. Morales, MD, Pediatric Rheumatology, Allergy and Immunology Unit, Division of Pediatrics, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile, Dr. Veronica Mezzano, MD, Department of Rheumatology and Clinical Immunology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile, Ms. Sofia Nussbaum, Universidad de San Sebastian, Santiago, Chile and A. Wesley Burks, MD, FAAAAI, University of North Carolina, Chapel Hill, NC Evaluation Of a Diagnostic Protocol For Perioperative Anaphylaxis Due To Isosulfan Blue Dye Allergy Ms. Mary Grace Baker, University of Virginia School of Medicine, Charlottesville, VA, Julia A. Cronin, MD, University of Virginia, Division of Asthma, Allergy and Immunology, Charlottesville, VA, Dr. Larry Borish, MD, FAAAAI, Asthma and Allergic Diseases Center, Carter Center for Immunology Research, University of Virginia, Charlottesville, VA and Dr. Monica G. Lawrence, MD, University of Virginia Department of Medicine, Division of Asthma, Allergy and Immunology, Charlottesville, VA Acute Serum Tryptase Elevation In ALTE - An Atypical Manifestation Of Bullous Mastocytosis Dr. Alexander Alvarez, MD, Virginia Commonwealth University, Dr. Anne-Marie A. Irani, MD, FAAAAI, Virginia Commonwealth University Health Systems, Richmond, VA and Dr. Lawrence B. Schwartz, MD, PhD, FAAAAI, Virginia Commonwealth University, Richmond, VA Methodology For Identifying Patients Presenting With Anaphylaxis Using Administrative Claims Data Jerald Seare, MD1, Erin Buysman, MS1, Dr. Ray A. Wolf, PharmD2, Paul Cavanaugh, Jr, PhD3, Aylin Altan Riedel, PhD1

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and Tim Bancroft, PhD1, 1OPTUM, Prairie Eden, MN, 2Mylan Specialty L.P., New Hope, PA, 3Mylan Specialty, Basking Ridge, NJ Epicare (Epinephrine Pen Investigation: Compliance and Recommendations) Dr. Nisha S. Patel, MD, Thomas Jefferson University, Philadelphia, PA, Dr. Christopher Chang, MD, PhD, FAAAAI, Alfred I duPont Hospital for Children, Wilmington, DE and Dr. Gang Ye, PhD, Nemours, Orlando, FL Confusion With Substituting Epinephrine Auto-Injectors: A Focus On Medication Counseling, Dispensing, and Patient Education Sonia Dhanjal, PharmD and Stacie Lampkin, PharmD, BCACP, AE-C, D’Youville College School of Pharmacy, Buffalo, NY Omalizumab For a Case Of Monoclonal Mast Cell Activation Syndrome With Recurrent Anaphylaxis Dr. Amanda Jagdis, University of Toronto, Faculty of Medicine, Toronto, ON, Canada and Dr. Peter Vadas, MD, PhD, St. Michael’s Hospital, Toronto, ON, Canada Chlorhexidine Impregnated Central Venous Lines: A Potentially Avoidable Cause Of Severe Perioperative Anaphylaxis Dr. Aisha Ahmed, MD and Dr. Katherine E. Gundling, MD, UCSF, San Francisco, CA Food Dependent Exercise Induced Anaphylaxis Treatment With Specific Oral Tolerance Induction Using IFN-Gamma Dr. Jae Ho Lee, MD, PhD, Department of Pediatrics, Chungnam National University, Taejeon, South Korea, Dr. Sun Young You, MD, Department of Pediatrics, Taejeon, South Korea and Dr. Hye Young Han, MD, Department of Pediatrics, School of Medicine, Chungnam National University, Taejeon, South Korea Food Associated Exercise Induced Anaphylaxis Associated With Late Phase Skin Test Reactivity To Shrimp Dr. Marisol Nardi, New York Downtown Hospital, New York and Dr. Robert Yao-Wen Lin, FAAAAI, New York Downtown Hospital, New York, NY; Weill Cornell Medical College, New York, NY Idiopathic Capillary Leak Syndrome Dr. Carl B. Lauter, MD, FAAAAI, William Beaumont Hospital Comprehensive Metabolomic Analysis Identifies Uric Acid As a Critical Mediator Of Peanut Sensitization Mr. Joshua Kong1, Dr. Kenneth Chalcraft, PhD2, Dr. Rodrigo Jimenez-Saiz, PhD1, Mrs. Tina Walker-Fattouh2, Dr. Susanna Goncharova, MD, PhD2, Dr. Brian McCarry, PhD2 and Dr. Manel Jordana, MD, PhD1, 1McMaster Immunology Research Centre (MIRC), McMaster University, Hamilton, ON, Canada, 2McMaster University, Hamilton, ON, Canada Pharmacokinetics Of Berberine, a Bioactive Compound In Butanol Purified Food Allergy Herbal Formula-2 Dr. Nan Yang, PhD, MS1, Dr. Ying Song, MD1, Dr. Changda Liu, PhD1, Sool Yeon Cho, PhD2 and Dr. Xiu-Min Li, MD1, 1Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 2Hematology, Icahn School of Medicine at Mount Sinai, New York City, NY Anaphylaxis After Bitten By Domestic Hamster: A Case Report Dr. Leila Borges, MD1, Dr. Danielle Bichueti Silva, MD2, Dr. Tessa Rachel Tranquilini Gonc¸alves, MD3, Dr. Rafael Rota, MD3, Camila Gonzaga da Silva4, Dr. Danieli Hirari, MD4, Dr. Marcia Mallozi, MD5 and Prof. Dirceu Sole, MD, PhD3, 1UNIFESP, Brazil, 2Universidade Federal de S~ao Paulo, S~ao Paulo, Brazil, 3Federal University of Sao Paulo, Sao Paulo, Brazil, 4Federal University of S~ao Paulo, S~ao Paulo, Brazil, 5Federal University of S~ao Paulo, Brazil Gene Expression Profiling Of Food-Induced Anaphylaxis Associated With Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Dr. Rosa M. Munoz-Cano, MD, PhD1,2, Dr. Joan Bartra, MD, PhD2, Dr. Jorg Scheffel, PhD1, Dr. Mariona Pascal, PhD3, Dr. Barbara Dema, PhD1, Dr. Antonio Valero, MD, PhD2, Dr. Ana Olivera, PhD1, Prof. Cesar Picado, MD, PhD2 and Dr. Juan Rivera, PhD1, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS),

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National Institutes of Health, Bethesda, MD, 2Unitat d’Al.lergia. Servei de Neumologia i Al.lergia Respiratoria. Hospital Clinic. Barcelona. Institut d’Investigacions Biom!ediques August Pi i Sunyer (IDIBAPS)., Barcelona, Spain, 3Servei d’Immunologia, Centre de Diagnostic Biomedic. Hospital Clinic., Barcelona, Spain Recurrence Rates Of Anaphylaxis In Children Dr. Andrew O’Keefe, MD1,2, Dr. Yuka Asai, MD3,4, Mr. Christopher Mill, BSc3, Dr. Harley Eisman, MD5, Dr. Sebastian La Vieille, MD6, Dr. Reza Alizadehfar, MD5,7, Ms. Emma Perkins, BSc3, Dr. Lawrence Joseph, PhD3, Dr. Ann Elaine Clarke, MD, MSc3,8 and Dr. Moshe Ben-Shoshan, MD, MSc5,9, 1McGill University, Montreal, Canada, QC, Canada, 2Division of Pediatric Allergy and Clinical Immunology, Montreal Children’s Hospital, Canada, 3Division of Clinical Epidemiology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada, 4Division of Dermatology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada, 5McGill University, Montreal, QC, Canada, 6 Food Directorate, Health Canada, Ottawa, ON, Canada, 7Division of Paediatric Allergy and Clinical Immunology, Department of Paediatrics, McGill University Health Center, Montreal, QC, Canada, 8 Montreal General Hospital, 9Montreal Children’s Hospital, Montreal, Canada Sensitization To Recombinant Allergens Of Hevea Brasilensis In Patients With Latex Anaphylaxis omez Infante, MD1, Dr. J.M. Escobar Montalvo, MD1, Ms. A. G" Dr. Silvia Mart"ınez Blanco, MD2 and Dr. R. Vives Conesa, MD1, 1 Hospital Universitario 12 de Octubre, Madrid, Spain, 2Hospital Universitario 12 de Octubre, Spain Patients Monosensitised To Hev b 8 Performs Surgery Without Avoidance The Latex and Without Complications Dr. Adriano Sa, MD, Federal University of S~ao Paulo, S~ao Paulo, Brazil, Dr. Leila Borges, MD, UNIFESP, Brazil, Dr. Nathalia Barroso, Federal University of Sao Paulo, Dr. Luis Felipe C. Ensina, MD, Universidade Federal de S~ao Paulo, S~ao Paulo, Brazil, Ines Nunes, Federal University of S~ao P~aulo and Prof. Dirceu Sole, MD, PhD, Federal University of Sao Paulo, Sao Paulo, Brazil

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Home Treatment With Conestat Alfa In Attacks Of Hereditary Angioedema Due To C1-Inhibitor Deficiency Henriette Farkas, MD, PhD DSc1, Dr. Erika Szabo1, Dr. Dorottya oria Kohalmi1, Dr. Zsuzsanna Zotter1 Csuka, PhD2, Dr. Kinga, Vikt" and Dr. Lilian Varga, PhD1, 1Semmelweis University, Budapest, Hungary, 2Hungarian HAE Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary Comparison Of Plasma Kallikrein Inhibition By The Monoclonal Antibody Inhibitor DX-2930 To Endogenous C1-INH Daniel Sexton, Jon Kenniston, Ryan Faucette, Andrew Nixon, Christopher TenHoor, Yung H. Chyung and Burt Adelman, Dyax Corp. The Prophylactic Use Of C1 Esterase Inhibitor (Berinert) In HAE Patients Undergoing Invasive Procedures Rachel Harrison, BSc1, Stephanie Santucci, RN1, Genevieve Gavigan, MASc, MD2 and William H. Yang, MD1,2, 1Allergy and Asthma Research Corp., Ottawa, ON, Canada, 2University of Ottawa Medical School, Ottawa, ON, Canada Self-Administration Of a Novel Subcutaneous Bradykinin B2 Receptor Antagonist, Icatibant (Firazyr), As An Effective Treatment Option In Patients With Hereditary Angioedema (HAE) Stephanie Santucci, RN1, Hoang Pham, MD 2016, BSc, BA2, Rachel Harrison, BSc1 and William H. Yang, MD1,2, 1Allergy and

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Asthma Research Corp., Ottawa, ON, Canada, 2University of Ottawa Medical School, Ottawa, ON, Canada Current Medical Management Of Hereditary Angioedema (HAE): Follow-Up To a Large Survey Of US Physicians Dr. Marc A. Riedl, MD, MS, University of California, San Diego, La Jolla, CA, Dr. Richard G. Gower, MD, FAAAAI, Marycliff Allergy Specialists, Spokane, WA and Dr. Aleena Banerji, MD, Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA HAE In a Southern Louisiana Kindred: Novel Gene Mutations Dr. Adrian Casillas, MD, FAAAAI, Baylor College of Medicine, Houston, TX Hereditary Angioedema Without C1 Inhibitor Deficiency: Observation Of Patients Homozygous For FXII GENE Mutation Christiane Stieber1, Camila Veronez2, Nathalia Cagini2, Elisabete Cordeiro3, Dr. Anete S. Grumach3, Rosemeire Constantino-Silva3, Joao Bosco Pesquero2 and Sven Cichon4, 1Life & Brain Center and Institute of Human Genetics, University of Bonn, Germany, 2 Federal University of S~ao Paulo, Brazil, 3Faculty of Medicine ABC, Brazil, 4Division of Medical Genetics, Department of Biomedicine, University of Basel, Switzerland Hereditary Angioedema Without C1 Inhibitor Deficiency: Clinical Evaluation Of 67 Brazilian Patients Elisabete Cordeiro1, Camila Veronez2, Christiane Stieber3, Nathalia Cagini2, Rosemeire Constantino-Silva1, Rozana Gonc¸alves4, Gustavo Fusaro4, Neusa Wandalsen1, Sven Cichon5, Joao Bosco Pesquero2 and Dr. Anete S. Grumach1, 1Faculty of Medicine ABC, Brazil, 2Federal University of S~ao Paulo, Brazil, 3Life & Brain Center and Institute of Human Genetics, University of Bonn, Germany, 4Federal University of Minas Gerais, Brazil, 5Division of Medical Genetics, Department of Biomedicine, University of Basel, Switzerland Circulating Extracellular Micrornas In Hereditary Angioedema Peisong Gao, MD, PhD1, Kenneth Witwer, PhD2, Melissa McAlexander2, Priya Tripathi, PhD1, Tamara Johnson3 and Dr. Huamin Henry Li, MD, PhD, FAAAAI3, 1Division of Allergy & Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Johns Hopkins Institute for NanoBioTechnology, Baltimore, MD, 3Institute for Asthma and Allergy, Chevy Chase, MD Hereditary Angioedema In The Pediatric Patient Dr. Gregory H. Bennett, DO, Penn State Children’s Hospital, Hershey, PA and Dr. Timothy J. Craig, DO, FAAAAI, Penn State University College of Medicine, Hershey, PA Clinical Features Of Pediatric Hereditary Angioedema Shelby N. Elenburg, MD1, Amal H. Assa’ad, MD, FAAAAI2, Dr. Jonathan A. Bernstein, MD, FAAAAI3 and Maya Nanda, MD2, 1 University of Tennessee Health Science Center, Memphis, TN, 2 Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 3 Division of Immunology Allergy & Rheumatology, University of Cincinnati Medical Center, Cincinnati, OH A Case Series Of Seven Pediatric Patients Successfully Treated With Ecallantide and Icatibant For Hereditary Angioedema Heather Minto, MD1,2 and Kelly M. Maples, MD1,2, 1Eastern Virginia Medical School, Norfolk, VA, 2Children’s Hospital of The King’s Daughters, Norfolk, VA IHAE-Qol: Specific Health-Related Quality Of Life (HRQoL) Questionnaire In Hereditary Angioedema Due To C1 Inhibitor Deficiency (HAE-C1INH) Dr. Nieves Prior, MD1, Prof. Eduardo Remor2, Elia P!erez-Fern!anomez-Traseira, MD4, Dr. Magdalena Julia dez, MSc3, Dr. Carmen G! Caminoa, MD4, Francisco Gay!a5, Prof. Werner Aberer, MD6, Dr. Olga Melcina Barrera, MD7, Dr. Stephen D. Betschel, MD8, Prof. Laurence Bouillet, MD, PhD9, Prof. Anette Bygum, MD10, Henriette Farkas, MD, PhD DSc11, Dr. Anete S. Grumach12, Dr.

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Vesna Grivcheva- Panovska, MD, PhD13, Dr. Marcel Levi, MD14, Dr. Hilary Longhurst, MD15, Dr. Alejandro Malbran, MD16, Dr. Dumitru Moldovan, MD, PhD17, Dr. Gregor Porebski, MD18, Dr. Avner Reshef, MD19, Dr. Petra Staubach, MD20, Dr. Andrea Zanichelli, MD21, Dr. Yu-xiang Zhi, MD22 and Dr. Teresa Caballero, MD, PhD4,23, 1Hospital Universitario Severo Ochoa, Madrid, Spain, 2Psychology Faculty, Universidad Autonoma, Madrid, Spain, 3Hospital Universitario Fundaci!on Alcorc!on, Madrid, Spain, 4 Allergy Department, Hospital La Paz Institute for Health Research (IdiPaz), Madrid, Spain, 5Research Unit, Hospital La Paz Institute for Health Research (IdiPaz), Madrid, Spain, 6Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria, 7Institute of Pneumology and Allergy. San Fernando’s Hospital, Panama City, Panama, 8University of Toronto, Division of Clinical Immunology and Allergy, Toronto, ON, Canada, 9National Reference Centre for Angioedema, Internal Medicine Department, Grenoble University Hospital, Grenoble, France, 10 Denmark HAE Centre, Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark, 11Hungarian HAE Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary, 12Department of Dermatology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil, 13Unit of Allergology and Clinical Immunology. Department of Dermatology. Medicine School University Sts Cyril and Methodius, Skopje, Macedonia, 14Department of Internal Medicine,Academic Medical Center,University of Amsterdam., Amsterdam, Netherlands, 15Barts Health NHS Trust, London, United Kingdom, 16British Hospital of Buenos Aires, Buenos Aires, Argentina, 17Department of Allergology–Immunology, Mures County Hospital, Tirgu-Mures, Romania, 18Department of Clinical and Environmental Allergology, Jagiellonian University,, Krakow, Poland, 19 Allergy, Clinical Immunology & Angioedema Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel, 20Department of Dermatology, University Medical Center, University of Mainz, Mainz, Germany, 21Internal Medicine Department, Luigi Sacco Hospital, Milan, Italy, 22Peking Union Medical College Hospital, Beijing, China, 23Biomedical Research Network on Rare Diseases (CIBERER, U754), Madrid, Spain Relationship Between Angioedema Attacks and Health-Related Quality Of Life Outcomes In Patients With Hereditary Angioedema (HAE) Dr. Jeff Dayno, MD1, Dave P. Miller2, Ms. Emily Hautamaki, MPH3, Scott Newcomer1, David Fitts1 and Dr. William R. Lumry, MD, FAAAAI4,5, 1ViroPharma Incorporated, 2ICON Clinical Research, 3Oxford Outcomes, an ICON plc company, 4AARA Research Center, Dallas, TX, 5Allergy and Asthma Specialists, Dallas, TX Health-Related Quality Of Life (HRQoL) In Adult Patients With Hereditary Angioedema Due To C1 Inhibitor Deficiency (HAE-C1-INH) Assessed By SF-36v2 Dr. Teresa Caballero, MD, PhD1,2, Dr. Magdalena Julia Caminoa, MD1, Elia P!erez-Fern!andez, MSc3, Dr. Carmen G!omez-Traseira, MD1, Dr. Anne Aabom, MD4, Prof. Werner Aberer, MD5, Dr. Stephen D. Betschel, MD6, Prof. Anette Bygum, MD4, Dr. Dorottya Csuka, PhD7, Henriette Farkas, MD, PhD DSc7, Dr. Maria Gomide, MD8, Dr. Adriane Groffik, MD9, Dr. Anete S. Grumach8, Mrs. Iris Leivobich10, Dr. Alejandro Malbran, MD11, Dr. Eniko Mihaly, MD12, Dr. Dumitru Moldovan, MD, PhD13, Dr. Krystyna Obtulowicz, MD14, Dr. Gregor Porebski, MD15, Mrs. Celina Rayonne16, Dr. Avner Reshef, MD10, Dr. Petra Staubach, MD9, Dr. Michaela Wiednig, MD5, Maria Joao Forjaz17,18 and Dr. Nieves Prior, MD19, 1Allergy Department, Hospital La Paz Institute for Health Research (IdiPaz), Madrid, Spain, 2Biomedical Research Network on Rare Diseases (CIBERER, U754), Madrid, Spain, 3Hospital Universitario Fundaci!on Alcorc!on, Madrid, Spain, 4Denmark HAE Centre, Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark,

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Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria, 6University of Toronto, Division of Clinical Immunology and Allergy, Toronto, ON, Canada, 7Hungarian HAE Center, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary, 8Department of Dermatology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil, 9Department of Dermatology, University Medical Center, University of Mainz, Mainz, Germany, 10Allergy, Clinical Immunology & Angioedema Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel, 11British Hospital of Buenos Aires, Buenos Aires, Argentina, 12Department of Allergology–Immunology, Mures County Hospital, Tırgu-Mures, Romania, 13Department of Allergology–Immunology, Mures County Hospital, TirguMures, Romania, Tirgu-Mures, Romania, 14Department of Clinical and Enviromental Medicine, Jagiellonian University, Krakow, Poland, 15Department of Clinical and Environmental Allergology, Jagiellonian University, Krakow, Poland, 16ReSolve Research Solutions Inc., Whitby, Ontario, Canada, 17National School of Public Health, Carlos III Institute of Public Health, Madrid, Spain, 18 REDISSEC, Madrid, Spain, 19Hospital Universitario Severo Ochoa, Madrid, Spain The Icatibant Outcome Survey: Characteristics Of Patients With Hereditary Angioedema Requiring Reinjection Dr. Hilary Longhurst, MD, Barts Health NHS Trust, London, United Kingdom, Prof. Marcus Maurer, MD, Department of Dermatology and Allergy, Charit!e – Universit€atsmedizin, Berlin, Germany, Dr. Vincent Fabien, PhD, Shire, Eysins, Switzerland, Prof. Werner Aberer, MD, Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria, Prof. Laurence Bouillet, MD, PhD, National Reference Centre for Angioedema, Internal Medicine Department, Grenoble University Hospital, Grenoble, France, Dr. Andrea Zanichelli, MD, Dipartimento di Scienze Biomediche e Cliniche, Ospedale Luigi Sacco, Universita degli Studi di Milano, Milan, Italy and Dr. Teresa Caballero, MD, PhD, Allergy Department, Hospital La Paz Institute for Health Research (IdiPaz), Madrid, Spain The Icatibant Outcome Survey: Characterizing Breakthrough Hereditary Angioedema Attacks In Patients Receiving LongTerm Prophylaxis Prof. Werner Aberer, MD, Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria, Prof. Marcus Maurer, MD, Department of Dermatology and Allergy, Charit!e – Universit€atsmedizin, Berlin, Germany, Prof. Laurence Bouillet, MD, PhD, National Reference Centre for Angioedema, Internal Medicine Department, Grenoble University Hospital, Grenoble, France, Amandine Perrin, Shire, Eysins, Switzerland, Dr. Andrea Zanichelli, MD, Dipartimento di Scienze Biomediche e Cliniche, Ospedale Luigi Sacco, Universita degli Studi di Milano, Milan, Italy, Dr. Teresa Caballero, MD, PhD, Allergy Department, Hospital La Paz Institute for Health Research (IdiPaz), Madrid, Spain and Dr. Hilary Longhurst, MD, Barts Health NHS Trust, London, United Kingdom The Icatibant Outcome Survey: Rate and Impact Of Treatment By Self-Administration Dr. Dolores Hern! andez Fern! andez de Rojas, MD1, Dr. Ethel 1 Ib!a~ nez, MD , Dr. Hilary Longhurst, MD2, Prof. Marcus Maurer, MD3, Dr. Vincent Fabien, PhD4, Prof. Werner Aberer, MD5, Prof. Laurence Bouillet, MD, PhD6, Dr. Andrea Zanichelli, MD7 and Dr. Teresa Caballero, MD, PhD8, 1IIS Hospital Universitario La Fe, Valencia, Spain, 2Barts Health NHS Trust, London, United Kingdom, 3Department of Dermatology and Allergy, Charit!e – Universit€atsmedizin, Berlin, Germany, 4Shire, Eysins, Switzerland, 5 Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria, 6National Reference Centre for Angioedema, Internal Medicine Department, Grenoble University Hospital, Grenoble, France, 7Dipartimento di Scienze Biomediche e Cliniche, Ospedale Luigi Sacco, Universita degli Studi di Milano,

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Milan, Italy, 8Allergy Department, Hospital La Paz Institute for Health Research (IdiPaz), Madrid, Spain Most Hereditary Angioedema (HAE) Attacks Resolved After One Icatibant Injection: Analysis Of FAST-3 Open-Label Extension Study Dr. William R. Lumry, MD, FAAAAI, Allergy and Asthma Specialists, Dallas, TX, Jovanna Baptista, MS, Shire, Lexington, MA, Dr. Marc A. Riedl, MD, MS, University of California, San Diego, La Jolla, CA and Dr. Timothy J. Craig, DO, FAAAAI, Penn State University College of Medicine, Hershey, PA Evaluation Of Icatibant Reinjection Of Laryngeal Hereditary Angioedema Attacks: A Pooled Analysis Of Three Phase III Open-Label Extension Studies Jovanna Baptista, MS, Shire, Lexington, MA, Dr. Jonathan A. Bernstein, MD, FAAAAI, Division of Immunology Allergy & Rheumatology, University of Cincinnati Medical Center, Cincinnati, OH, Dr. William R. Lumry, MD, FAAAAI, Allergy and Asthma Specialists, Dallas, TX and Dr. Marc A. Riedl, MD, MS, University of California, San Diego, La Jolla, CA Successful and Safe Use Of Icatibant For Life-Threatening Angioedema Attack During Pregnancy In a Patient With Hereditary Angioedema Type I Dr. Karine Boufleur, MD1, Ms. Luana Delcaro1, Dr. Daniel L. Cordeiro, MD1, Dr. Priscila B. Botelho Palhas, MD1, Dr. Janaina Fernandes de Melo Sousa, MD1, Dr. Tha!ıs Mendonc¸a, MD1, Dr. Janaina Michele de Lima Melo, MD1, Dr. Gustavo Neppelenbroek, MD1, Prof. Wlly Sarti1, Dr. Adriana S. Moreno, PhD1 and Dr. Luisa Karla P. Arruda, MD, PhD, FAAAAI2, 1Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil, 2School of Medicine of Ribeirao Preto, Ribeirao Preto, Brazil Recombinant Human C1 Inhibitor Treatment Does Not Affect D-Dimer Levels and Is Not Associated With Thromboembolic Events In HAE Patients Dr. Avner Reshef, MD, Allergy, Clinical Immunology & Angioedema Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel, Dr. Andrea Zanichelli, MD, Dipartimento di Scienze Biomediche e Cliniche, Ospedale Luigi Sacco, Universita degli Studi di Milano, Milan, Italy, Dr. Hilary Longhurst, MD, Barts Health NHS Trust, London, United Kingdom, Yun Hardiman, MS, Santarus Inc., San Diego, CA, Anurag Relan, MD, Pharming Technologies BV, Leiden, Netherlands and C. Erik Hack, MD, University Medical Center Utrecht, Utrecht, Netherlands C1-Esterase Inhibitor Concentrate For Acute Attacks Of Laryngeal Edema In Hereditary Angioedema (HAE): Fixed Dosing Vs Body Weight-Adjusted Dosing Konrad Bork, MD1, Dr. Jonathan A. Bernstein, MD, FAAAAI2, Henrike Feuersenger3, Thomas Machnig3 and Dr. Timothy J. Craig, DO, FAAAAI4, 1University of Mainz, Mainz, Germany, 2Division of Immunology Allergy & Rheumatology, University of Cincinnati Medical Center, Cincinnati, OH, 3CSL Behring GmbH, Marburg, Germany, 4Penn State University College of Medicine, Hershey, PA Sustained Response Following Acute Treatment Of Hereditary Angioedema Attacks With Recombinant Human C1 Esterase Inhibitor H.Henry Li, MD, PhD, Institute for Asthma and Allergy, Chevy Chase, MD, Dr. Marc A. Riedl, MD, MS, University of California, San Diego, La Jolla, CA, Dr. Jonathan A. Bernstein, MD, FAAAAI, Division of Immunology Allergy & Rheumatology, University of Cincinnati Medical Center, Cincinnati, OH, Dr. William R. Lumry, MD, FAAAAI, AARA Research Center, Dallas, TX, Dr. Avner Reshef, MD, Allergy, Clinical Immunology & Angioedema Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel, Dr. Dumitru Moldovan, MD, PhD, Department of Allergology–Immunology, Mures County Hospital, Tirgu-Mures, Romania, Tirgu-Mures, Romania, Henriette Farkas, MD, PhD DSc, Semmelweis University, Budapest, Hungary, Dr. Gregor Porebski, MD, Department of Clinical and Environmental Allergology, Jagiellonian University,

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Krakow, Poland, Marcin Stobiecki, MD, Jagiellonian University College, Krakow, Poland, Yun Hardiman, MS, Santarus Inc., San Diego, CA, Anurag Relan, MD, Pharming Technologies BV, Leiden, Netherlands and Prof. Marco Cicardi, MD, PhD, Department of Internal Medicine, Luigi Sacco Hospital, Milan, Italy, Milan, Italy Efficacy Of C1Inhibitor Concentrate (Berinert) For Severe Angioedema Attacks Induced By Drugs Targeting The Renin-Angiotensin Aldosterone System Prof. Laurence Bouillet, Grenoble university hospital, Grenoble, France, Dr. Bernard Floccard, Lyon university hospital, Lyon, France, Dr. Isabelle Boccon-Gibod, Grenoble University Hospital, Grenoble, France, Dr. Sebastien Trouiller, Centre hospitalierd ’Aurillac, Aurillac, France, Dr. Anne Du-Than, Montpellier university hospital, Montpellier, France and Prof. Olivier Fain, Jean Verdier universty hospital, Bondy, France Professional Administration Costs In The US For On-Demand Therapy Of Hereditary Angioedema Thomas Machnig, CSL Behring GmbH, Marburg, Germany and Mr. Art Zbrozek, RPh, MSc, MBA, CSL Behring LLC, King of Prussia, PA Successful Administration Of C1Esterase Inhibitor (C1inh) In An Individual Anaphylactic To It Dr. Arthur B. Vegh, MD, FAAAAI1, Ms. Marni Sellers2, Ms. Nancy Boyden2 and Ms. Jennifer Vegh2, 1University of Washington, Tacoma, WA, 2none, Tacoma, WA Evaluation Of DX-88 (Ecallantide) For Treatment Of Angiotensin Enzyme Inhibitor Induced Angioedema In The Emergency Department Dr. Joseph Moellman, MD1, Dr. Jonathan A. Bernstein, MD, FAAAAI2, Ms. Kimberly Hart1, Dr. Sean Collins3 and Dr. Christopher Lindsell1, 1University of Cincinnati, Cincinnati, OH, 2Division of Immunology Allergy & Rheumatology, University of Cincinnati Medical Center, Cincinnati, OH, 3Vanderbilt University, Nashville, TN Ecallantide In Treatment Of Type III Hereditary Angioedema Dr. Anil Nanda, MD, Asthma and Allergy Center, Lewisville, TX; UT Southwestern Medical Center, Dallas, TX and Dr. Anita N. Wasan, MD, Allergy and Asthma Center, Lansdowne, VA BCX4161, An Oral Kallikrein Inhibitor: Safety and Pharmacokinetic Results Of a Phase 1 Study In Healthy Volunteers Dr. Phil Collis1, Dr. Melanie Cornpropst1, Dr. Jo Collier2 and Dr. William Sheridan1, 1BioCryst Pharmaceuticals, Durham, NC, 2 Quotient Clinical, Nottingham, United Kingdom Treatment Of Hereditary Angioedema At The Time Of Prodromal Symptoms: International Survey Of Physicians Dr. Neelu Kalra, MD, Penn State Hershey Medical Center, Hershey, PA and Dr. Timothy J. Craig, DO, FAAAAI, Penn State University College of Medicine, Hershey, PA Structural and Molecular Changes Caused By Mutations Thr328Lys and Thr328Arg In FXII Associated With Hereditary Angioedema With Normal C1 Inhibitor Dr. Adriana S. Moreno, PhD, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil, Dr. Helen Arcuri, PhD, Institute of Investigation in Immunology iii, School of Medicine of the University of Sao Paulo, S~ao Paulo, Brazil, Prof. Mario Palma, PhD, Biosciences Institute, State University of S~ao Paulo, Rio Claro, Brazil and Dr. Luisa Karla P. Arruda, MD, PhD, FAAAAI, School of Medicine of Ribeirao Preto, Ribeirao Preto, Brazil Ludwig’s Angina Masquerading As Angioedema Dr. Lynn A. Wiens, MD, FAAAAI, Warren Clinic, Tulsa, OK A Simple, Sensitive and Selective Fluorogenic Assay To Monitor Plasma Kallikrein Inhibitory Activity Of BCX4161 In Activated Plasma Dr. YS Babu1, Ms. Ramanda Wilson1, Dr. Jianwen Zhang1, Dr. Melanie Cornpropst2, Dr. Phil Collis2 and Dr. William Sheridan2,

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BioCryst Pharmaceuticals, Inc, Birmingham, AL, 2BioCryst Pharmaceuticals, Durham, NC Incidence and Treatment Of Angioedema In a Third Level Spanish Hospital Marta Seoane, MD, Maria Elisa Caralli, MD, Sarah Micozzi, MD, Marta Elena Rodriguez-Mazariego, MD and Mar!ıa L. Baeza, MD, PhD, Hospital General Universitario Gregorio Mara~n!on, Allergy Department, Madrid, Spain Seasonal Increase In Angioedema In An Inner City Hospital Center Helen Zhou, BS, Dr. Ashlei Mathew, MD and Dr. Rauno Joks, MD, Center for Allergy and Asthma Research, State University of New York Downstate Medical Center, Brooklyn, NY Seeming Tongue Swelling Responding To Nebulized Ipratropium In An Individual With A Diagnosis Of Type III HAE (Hereditary Angioedema) Ms. Jennifer Vegh1, Dr. Arthur B. Vegh, MD, FAAAAI2 and Ms. Nicholette Butler1, 1none, Tacoma, WA, 2University of Washington, Tacoma, WA Cytokine Expression In a Case Of Cutaneous Mastocytosis With An Unusual Presentation Prof. Young Min Ahn, MD, Department of Pediatrics, South Korea, Prof. sang-Hoon Kim, Department of Internal Medicine, South Korea, Prof. Ho-jung Lee, Department of Pathology,Eulji University School of Medicine, South Korea and Prof. Jai Youl Ro, PhD, Sungkyunkwan University School of Medicine, South Korea

Population, Health in Asthma 2208 Saturday, March 1st, 2014, 9:45 AM - 10:45 AM 148

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Aerochambers and Asthmatics: Do No Harm? Dr. Jack Leon-Max Mutnick, MD, Stevens Community Medical Center, Morris, MN Characterizing The Severe Asthma Population In The United States: Claims-Based Analysis Of Three Treatment Cohorts In The Year Prior To Treatment Escalation Dr. Patrick W. Sullivan, PhD1, Dr. Jon Campbell, PhD2, Dr. Vahram Ghushchyan, PhD2, Dr. Gary Globe, PhD3, Dr. Jeff Lange, PhD3 and Dr. J Michael Woolley, PhD3, 1Regis University, 2University of Colorado Denver, 3Amgen, Inc., Thousand Oaks, CA Impact Of Asthma On Child and Family Activities Among a Rural Cohort Dr. Allison J. Burbank1,2, Mallikarjuna Rettiganti, PhD1,2, Paige Fisher, BA3 and Tamara T. Perry, MD1,2, 1University of Arkansas for Medical Sciences, Little Rock, AR, 2Arkansas Children’s Hospital, Little Rock, AR, 3Drexel University School of Public Health, Philadelphia, PA Inhaled Asthma Medications: Highlighting The Differences In Formulations and Use Dr. Lachara Lvingston Livingston, University of South Florida Morsoni College of Medicine, Dr. Gregory Michael Cowan, MD, University of South Florida Morsani College of Medicine and Dr. Richard F. Lockey, MD, Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine and James A. Haley Veterans’ Affairs Hospital, Tampa, FL Rhinitis and Asthma Exacerbation Revealing Large Pulmonary Effusion and Pelvic Mass Dr. Jennifer Olivier, MD, Tulane University School of Medicine, New Orleans, LA and Dr. Laurianne G. Wild, MD, FAAAAI, Tulane University, New Orleans, LA

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Deprivation Is Longitudinally Associated With Incident Childhood Asthma Dr. Elinor Simons, MD, MS, FAAAAI1,2, Dr. Sharon Dell, MD2,3, Dr. Rahim Moineddin, PhD4,5 and Dr. Teresa To, PhD1,5, 1Child Health Evaluative Sciences, Hospital for Sick Children, Toronto, ON, Canada, 2Clinical Epidemiology, Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada, 3Respiratory Medicine and Child Health Evaluative Sciences, Hospital for Sick Children, Toronto, ON, Canada, 4Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada, 5Institute for Clinical Evaluative Sciences, Toronto, ON, Canada Use Of Asthma Control Indicators In Measuring Efficacy Of Inhaled Corticosteroids In Asthmatic Smokers: A Systematic Review Ms. Claire E. Hayes, MPH, CHES, AE-C and Mr. Henry Nuss, PhD, Louisiana State University Health Sciences Center School of Public Health, New Orleans, LA Evaluation Of a Medication Adherence Estimator Survey Compared To Exhaled Nitric Oxide (FeNO) Levels and Asthma Control Test In Difficult-To-Treat/Severe Pediatric Asthma Patients Jigar Patel1, Vanessa Y. Cavero, MD2, Amy Perkins, MS2, Heather Minto, MD2 and Maripaz B. Morales, MD2, 1 Department of Pediatrics, Eastern Virginia Medical School, Norfolk, VA, 2Children’s Hospital of The King’s Daughters, Norfolk, VA

Healthcare Delivery in Primary Immunodeficiency 2209 Saturday, March 1st, 2014, 9:45 AM - 10:45 AM 156

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An Assessment Of Infection Rates and Health Resource Use Among Primary Immunodeficiency Disorder (PIDD) Patients Prior To Diagnosis Dr. Chris Rabbat, PhD, Ms. Diane Ito, MA, Ms. Yan Xiong, MS and Dr. Josephine Li-McLeod, PhD, Baxter Healthcare Corporation, Westlake Village, CA A Comparison Of Costs Between Outpatient Hospital, Clinic and Home Settings For Intravenous Immunoglobulin (IVIG) Infusions Dr. Xiaolan Ye, PhD, Ms. Diane Ito, MA, Ms. Yan Xiong, MS and Dr. Josephine Li-McLeod, PhD, Baxter Healthcare Corporation, Westlake Village, CA Differences In Infection Rates Between Outpatient Hospital, Clinic and Home Infusion Settings For Patients With Primary Immunodeficiency Disorder (PIDD) Ms. Diane Ito, MA, Ms. Yan Xiong, MS, Dr. Xiaolan Ye, PhD and Dr. Josephine Li-McLeod, PhD, Baxter Healthcare Corporation, Westlake Village, CA Assessment Of The Quality Of Life and Health Resource Utilization Burden Among Patients With Primary Immunodeficiency Disorder (PIDD) Prior To Treatment Dr. John M. Routes, MD, FAAAAI1, Dr. Beatriz Tavares CostaCarvalho, MD2, Prof. Bodo Grimbacher, MD3, Dr. Kenneth Paris, MD, MPH4, Dr. Hans D. Ochs, MD5, Ms. Diane Ito, MA6, Ms. Yan Xiong, MS6, Dr. Josephine Li-McLeod, PhD6 and Dr. Richard I. Schiff, MD, PhD7, 1Medical College of Wisconsin, Milwaukee, WI, 2Federal University of Sao Paulo, Brazil, 3Royal Free Hospital & University College, London, United Kingdom, 4 LSU Health Sciences Center, New Orleans, New Orleans, LA, 5 University of Washington, Seattle, WA, 6Baxter Healthcare Corporation, Westlake Village, CA, 7Baxter BioScience, Westlake Village, CA

Diagnostics 2210 Saturday, March 1st, 2014, 9:45 AM - 10:45 AM 160

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Phadiatop - An Atopy Test With Optimal Allergen Composition Relevant For Most Geographical Regions Kerstin M. Wall1, Monica Noren1 and Dr. Cathy Van Rooyen2, 1 Thermo Fisher Scientific, ImmunoDiagnostics, Uppsala, Sweden, 2 Ampath National Reference Laboratory, Immunology, Pretoria, South Africa Histamine Skin Reactivity Increased With Body Mass Index In Korean Children Dr. Jeon Mi Lee, Dr. Ju Wan Kang and Dr. Hyung Ju Cho, Yonsei University College of Medicine The Impact Of Component Resolved Diagnosis On AllergenSpecific Immunotherapy Prescription In Children With Pollen-Related Allergic Rhinitis Dr. Paolo Matricardi, MD1, Dr. Giovanna Stringari2, Prof. Carlo Caffarelli2, Dr. Riccardo Asero, MD3, Dr. Arianna Dondi4, Dr. Salvatore Tripodi5 and The Italian Pediatric Allergy Network6, 1 Charite, Berlin, Germany, 2Pediatric Department, University of Parma, Parma, Italy, 3Clinica San Carlo, Paderno Dugnano, Italy, 4 Department of Pediatrics, University of Bologna, Bologna, Italy, 5 Pediatric Department, Ospedale Sandro Pertini, Roma, Italy, 6. Randomized Evaluation Of Ten Allergy Skin Prick Test Devices Dr. Yohalakshmi Chelladurai, MD, MPH1, Prof. Robert G. Hamilton, PhD D.ABMLI FAAAAI2 and Dr. Jody R. Tversky, MD2, 1 Johns Hopkins University Bloomberg School of Public Health, 2 Johns Hopkins University School of Medicine, Baltimore, MD Phenotypic Classification Of Allergen Polysensitization In Geriatric Adults Dr. Rohit Divekar, MBBS, PhD1, Dr. John B. Hagan, MD, FAAAAI2 and Hirohito Kita, MD2, 1Division of Allergic Diseases, Mayo Clinic, Rochester, MN, 2Mayo Clinic, Rochester, MN Analysis Of The Discordance Between Immunocap and Skin Prick Test For Common Allergens In Patients With Allergic Rhinitis Symptoms Dr. Do Yang Park1, Prof. Hyun Jun Kim1, Dr. Ju Wan Kang2, Prof. Yoo Suk Kim1 and Prof. Chang-Hoon Kim3, 1Ajou University School of Medicine, 2Yonsei University College of Medicine, 3Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea Role Of House Dust Mites In Allergic and Non Allergic Nasal Diseases Prof. Maged Refaat, MD1, Prof. Tarek Mansour1, Prof. Talaat Samny2, Prof. Ahmed Zaki3, Prof. Eman Osman1, Dr. Eman Ezzat1 and Dr. Eman Ahmed1, 1Department of Allergy and Clinical immunology,Ain Shams university, Cairo, Egypt, 2Department of ear,nose and throat diseases,Ain Shams university, Cairo, Egypt, 3Department of pathology,Ain Shams university, Cairo, Egypt Immunogenicity and IgE Blocking Capacity Of a Mixture Of Depigmented and Chemically Modified Allergens From Different Homologous Groups Dr. Victor Miguel Iraola, Mr. Jose Ramon Leonor, Dr. Marıa Morales, Dr. Raquel Moya, Dr. M. Angeles Lopez Matas, Dr. Ma Teresa Gallego and Dr. Jeronimo Carnes, Laboratorios LETI, Tres Cantos, Spain Modified Shuffled Blo t 5 Recombinant Allergen From Blomia Tropicalis Produces a Shift Of Antigenicity For Binding To IgG4 Isotype Dr. Ernesto Taketomi, MD, PhD1, Mrs. Barbara Avila, MSc1, Mrs. Karine Almeida, PhD1, Mrs. Deise Silva, PhD1, Prof. Odonırio Abrah~ao Junior, PhD2 and Prof. Jair Cunha-Junior, PhD1, 1Federal University of Uberl^andia, Uberlandia, Brazil, 2Federal University of Triangulo Mineiro, Uberaba, Brazil

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Abstracts AB303

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

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AB304 Abstracts

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Fernandez-Rivas, MD, PhD5 and Javier Martınez-Botas, PhD1,6, Hospital Universitario Ramon y Cajal. Instituto Ramon y Cajal para la Investigacion Sanitaria, Madrid, Spain, 2Hospital del Sureste, Arganda del Rey, Spain, 3Hospital Clınico San Carlos, Spain, 4 Hospital Universitario 12 de Octubre, Spain, 5Hospital Clınico San Carlos, Madrid, Spain, 6CIBER de Fisiopatologıa de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain

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Induction Of Arah2-Specific Memory B Cells Identified Using a Novel Tetramer-Based Approach Occurs Early and Transiently During Peanut Oral Immunotherapy Dr. Sarita U. Patil, MD1,2, Dr. Adebola Ogunniyi, PhD3, Mr. Alex Ma4, Ms. Alisa K. Brennan, B.S.5, Ms. Theadora Swenson, BA6, Mr. Agustin Calatroni, MA MS7, Dr. James Moon, PhD8, Dr. J.Christopher Love, PhD3 and Wayne G. Shreffler, MD, PhD, FAAAAI1,6, 1Harvard Medical School, Boston, MA, 2Allergy and Immunology, Massachusetts General Hospital, Boston, MA, 3Massachusetts Institute of Technology, Cambridge, MA, 4Massachusetts General Hospital, Charlestown, MA, 5Rush Medical College, Chicago, IL, 6Massachusetts General Hospital, Boston, MA, 7Rho, Inc., Chapel Hill, NC, 8Harvard Medical School, Charlestown, MA De Novo Generation Of Gastrointestinal Regulatory T Cells In Response To OIT and EPIT Leticia Tordesillas, PhD1, Lucie Mondoulet, PhD2, Pierre Henri Benhamou, MD2, Hugh A. Sampson, MD, FAAAAI3 and M. Cecilia Berin, PhD1, 1Icahn School of Medicine at Mount Sinai, New York, NY, 2DBV Technologies, Bagneux, France, 3Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY Long Term Protection Against New Sensitization After MilkEpit In Mice Sensitized To Milk Is Mediated By Tregs Pierre Henri Benhamou, MD1, Dr. Vincent Dioszeghy, PhD1, Mrs. Emilie Puteaux1, Mrs. Melanie Ligouis1, Mrs. Veronique Dhelft1, Mrs. Camille Plaquet1, Prof. Christophe Dupont, MD, PhD2 and Lucie Mondoulet, PhD1, 1DBV Technologies, Bagneux, France, 2Hopital Necker Enfants Malades, Paris, France Epicutaneous Immunotherapy-Induced Regulatory T Cells Could Migrate To More Various Sites Of Allergen Exposure Compared To Sublingual Or Subcutaneous Immunotherapy In Mice Sensitized To Peanut Dr. Vincent Dioszeghy, PhD1, Lucie Mondoulet, PhD1, Mrs. Veronique Dhelft1, Mrs. Melanie Ligouis1, Mrs. Emilie Puteaux1, Mrs. Camille Plaquet1, Prof. Christophe Dupont, MD, PhD2 and Pierre Henri Benhamou, MD1, 1DBV Technologies, Bagneux, France, 2Hopital Necker Enfants Malades, Paris, France Anaphylactic Reactions After Peanut Oral Immunotherapy Noam Berlin1, Dr. Amanda Jagdis1, Carly Barron2, Sean Maclachlan3, Mohana Giruparajah2, Nathan Leader4, Dennis Penn5 and Dr. Gordon L. Sussman, FAAAAI1, 1University of Toronto, Faculty of Medicine, Toronto, ON, Canada, 2Gordon Sussman Clinical Research Inc., Toronto, ON, Canada, 3University of Ottawa, Faculty of Medicine, Ottawa, ON, Canada, 4University of Melbourne, Faculty of Medicine, Melbourne, Australia, 5MastCell Pharmaceuticals, Inc., Raleigh, NC Evaluation Of The Immunological Mechanisms Involved In The Efficacy Of Sublingual Immunotherapy With Ltp (Pru p 3) In Allergic Patients Sensitized To Food By Ltps Dr. Francisca Gomez, MD, PhD1, Dr. Enrique Gomez, MD, PhD2, Dr. Maria J Torres, MD, PhD3, Mrs. Luisa Galindo, RN3, Ms. Maria Dolores Ruiz3, Dr. Inmaculada Do~ na, MD, PhD3, Mrs. Gador Bo1 gas , Dr. Paloma Campo, MD, PhD3, Dr. Teresa Posadas3, Dr. Miguel Blanca, MD, PhD3 and Dr. Cristobalina Mayorga, PhD4, 1 Allergy Service, Carlos Haya Hospital, Spain, 2Research Laboratory, Carlos Haya Hospital-FIMABIS, Spain, 3Allergy Service, Carlos Haya Hospital, Malaga, Spain, 4Research Laboratory, Carlos Haya Hospital-FIMABIS, Malaga, Spain Changes In IgE and IgG4 Epitopes After Milk Oral Immunotherapy (OIT) Belen de la Hoz Caballer, MD, PhD1, Mrs. Cristina Vlaicu1, Inmaculada Cerecedo Carballo, MD, PhD2, Monica RodrıguezAlvarez, MD3, Dr. Maria Carmen Dieguez Pastor, MD4, Montserrat

Mechanisms of Cytokines and Chemokines 2212 Saturday, March 1st, 2014, 9:45 AM - 10:45 AM 176

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IL-33 and TSLP Mediate Chronic Eosinophilic Airway Inflammation and IgE Antibody Production Induced by Multiple Airborne Allergens Koji Iijima, PhD1, Takao Kobayashi, PhD1, Kenichiro Hara, MD1,2, Gail Kephart1 and Hirohito Kita, MD1, 1Mayo Clinic, Rochester, MN, 2Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan IL-17 Enhances TNF-a-Induced, But Not IL-1b-Induced, Expression Of Neutrophil-Associated Cytokines By Human Lung Tissue Cells Dr. Akio Matsuda, PhD, Dr. Kenichiro Motomura, MD, Dr. Tetsuo Shoda, MD, Dr. Kyoko Futamura, MD, PhD, Dr. Hirohisa Saito, MD., PhD. and Dr. Kenji Matsumoto, MD, PhD, Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan Prostaglandin I2Receptor (IP) Signaling Inhibits Alternaria-Induced IL-5 and IL-13 Expression Through Group 2 Innate Lymphoid Cells (ILC2) Dr. Shinji Toki, PhD, Kasia Goleniewska, Sara Reiss, MS, Dr. Weisong Zhou, PhD and Dr. R. Stokes Peebles Jr., MD, FAAAAI, Vanderbilt University School of Medicine, Nashville, TN Local Administration Of CCL28 Is Sufficient To Drive Airway Hyper-Responsiveness and Mucous Cell Metaplasia Dr. Becky Buelow, MD, Mrs. Desire Hunter and Dr. Mitchell H. Grayson, MD, FAAAAI, Medical College of Wisconsin, Milwaukee, WI Mucosal Uric Acid Induces Interleukin 33 and Initiates Type 2 Immune Responses To Inhaled Protease Allergens Kenichiro Hara, MD1, Koji Iijima, PhD2, Takao Kobayashi, PhD2, Dr. Satoshi Seno3, Dr. Ichiro Tojima3, Gail Kephart2, Dr. Manabu Ueno1, Dr. Toshitaka Maeno1, Dr. Masahiko Kurabayashi1 and Hirohito Kita, MD2, 1Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan, 2Mayo Clinic, Rochester, MN, 3Shiga University of Medical Science, Otsu, Shiga, Japan Surrogate Biomarkers Of Eosinophilic Airway Inflammation In Asthma: Quantitation Of Major Basic Protein-1 and CharcotLeyden Crystal Protein/Galectin-10 In Induced Sputum Dr. Sharmilee M. Nyenhuis, MD, FAAAAI1,2, Mr. Preeth Alumkal, BS3, Dr. Jian Du, MD3, Brian Maybruck, PhD3, Mr. Mark Vinicky, BS3, Ms. Melissa Morales-Perez, BS3, Dr. Jerry A. Krishnan, MD, PhD4 and Dr. Steven J. Ackerman, PhD3, 1Jesse Brown VA Medical Center, Chicago, IL, 2MC 719, University of Illinois at Chicago, Chicago, IL, 3University of Illinois at Chicago, Chicago, IL, 4University of Illinois at Chicag, Chicago, IL IL-35-Producing T Cells (iTR35) Inhibit Th2 Effector Function, Induce Infectious Tolerance and Are Elevated Following Grass Pollen Sublingual Immunotherapy Dr. Mohamed H. Shamji, BSc MSc PhD1, Ms. Janice Layhadi, BSc( Hons)2, Mr. Alan Perera-web, BSc( Hons)2,3, Ms. Rachel Yan, RN4 and Prof. Stephen R. Durham, MA MD FRCP5, 1Imperial College London, South Kensington, United Kingdom, 2Imperial College London, 3Medical Research Council and Asthma UK Cen-

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tre for Allergic Mechanisms of Asthma, UK, 4Imperial College London, United Kingdom, 5Imperial College London, London, United Kingdom Th2 Cytokines Inhibit Toll-Like Receptor 2 Mediated Epidermal Barrier Repair Takeshi Yoshida, PhD1, I-Hsin Kuo, PhD1, Anna De Benedetto, MD, FAAAAI1, Donald Y.M. Leung, MD, PhD, FAAAAI2 and Lisa A. Beck, MD, FAAAAI1, 1University of Rochester Medical Center, Rochester, NY, 2National Jewish Health, Denver, CO Epicutaneous Sensitization To Food Allergens Induce IL-4-Producing Cells and T Follicular Helper (Tfh) Cells In An IL-6 and IL-1-Dependent Manner Ritobrata Goswami, PhD, Leticia Tordesillas, PhD and M. Cecilia Berin, PhD, Icahn School of Medicine at Mount Sinai, New York, NY Enhanced Thymic Stromal Lymphopoietin-Induced EosinophilBasophil Lineage Commitment In Atopic Individuals Claudia C.K. Hui, MSc1, Sina Rusta-Sallehy, BSc1, Dr. Ilan Asher, MD1, Delia Heroux, BSC1 and Judah Aryeh Denburg, MD, FRCPC, FAAAAI2, 1McMaster University, Hamilton, ON, Canada, 2Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, ON, Canada CMRF35-Like Molecule 1 (CLM-1) Is Required For IL-33-Induced Eosinophil Activation Dr. Ariel Munitz, PhD1, Mrs. Dana Shik1, Mr. Itay Moshkovits2 and Mrs. Danielle Karo-Atar1, 1Department of Clinical Microbiology and Immunology, The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel, 2Tel-Aviv University, Israel Role Of Interleukine-33 In Rhinovirus-Induced Allergic Asthma Exacerbation Dr. Marie Toussaint, DMV, PhD, Dr. Aran Singanayagam, MD, Prof. Sebastian L. Johnston, MD, PhD and Dr. Nathan Bartlett, PhD, Imperial College London, London, United Kingdom TGF-beta1 Mobilizes Mesenchymal Stem Cells In Allergic Asthma Ting Xu, MD1,2, Ling-Ling Xian, MD, PhD3, Yufeng Zhou, MD, PhD1, Beverly Plunkett, MS1, Xu Cao, PhD3, Mei Wan, MD, PhD3 and Peisong Gao, MD, PhD1, 1Division of Allergy & Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Department of Respiratory Medicine, Southern Medical University, Guangzhou, China, 3Department of Orthopedics Surgery, Johns Hopkins University School of Medicine, Baltimore, MD IL-10-Producing B Cells Are Increased After Grass Pollen Immunotherapy Compared To Untreated Grass Pollen Allergic Controls: A Blinded Cross-Sectional Study Mr. James E G Charlesworth1,2, Dr. Guy W Scadding, MD1,2, Dr. Aarif Eifan, MD2, Ms. Rachel Yan, RN2, Ms. Andrea Goldstone, RN2, Dr. Moises A. Calderon, MD, PhD1,2, Prof. Stephen R. Durham, MA MD FRCP3,4 and Dr. Mohamed H. Shamji, BSc MSc PhD5, 1 Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, United Kingdom, 2Imperial College London, United Kingdom, 3Imperial College London, London, United Kingdom, 4Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, London, United Kingdom, 5Imperial College London, South Kensington, United Kingdom Respiratory Syncytial Virus Induces IL-25 and IL-33 Production In The Lungs Matthew T. Stier1, Kasia Goleniewska2 and R. Stokes Peebles1,2, 1 Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, 2Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN Small-Molecule Inhibition Of Stat3 Prevents House-Dust-Mite (HDM)-Induced Airway Inflammation By Blocking Lung Production Of Th17 and Th2 Cytokines Dr. Aries C. Gavino, MD and Dr. David J. Tweardy, MD, Baylor College of Medicine, Houston, TX

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Differential Promoter Usage and Regulation Of The Human Interleukin-5 Receptor a (IL-5Ra) Gene In Developing Eosinophil Progenitors Kimberly G. Laffey, BSc, Dr. Jian Du, MD and Dr. Steven J. Ackerman, PhD, University of Illinois at Chicago, Chicago, IL Multiplex Cytokine Analysis Of Cord Blood Non-Adherent Mononuclear Cells From Infants With Attributable Atopic Risk Following Il-5 Stimulation Mrs. Jenny Thiele, MSc, Queens University, Kingston, ON, Canada, Ms. Vanessa N. Omana, MSc, Queen’s University, ON, Canada and Dr. Anne K. Ellis, MD, MSc FAAAAI, Allergy Research Unit, Kingston General Hospital, Kingston, ON, Canada; Departments of Medicine and Biomedical & Molecular Science, Queen’s University, Kingston, ON, Canada Association Of IL-33 With Atherogenic Cytokines: A Link Between Allergic Disease and Atherosclerosis Dr. Misu Paul, MD1, Dr. Allison B. Reiss, MD2, Dr. Steven Carsons, MD3, Dr. Luz S. Fonacier, MD, FAAAAI4 and Dr. Iryna Voloshyna, PhD2, 1Section of Allergy and Clinical Immunology, Department of Medicine, Winthrop University Hospital, mineola, NY, 2Winthrop Research Institute, Department of Medicine, Winthrop University Hospital, Mineola, NY, 3Division of Rheumatology, Allergy and Immunology, Department of Medicine, Winthrop University Hospital, Mineola, NY, 4Section of Allergy and Clinical Immunology, Department of Medicine, Winthrop University Hospital, Mineola, NY Modulation Of Human Basophil Degranulation By Geranylgeranyl Compounds Dr. Yuko Nakase1, Dr. Masao Yamaguchi1, Dr. Naoya Sugimoto1, Dr. Maho Suzukawa, MD2, Dr. Hiroyuki Tamiya1, Dr. Yasuhiro Kojima1, Dr. Hisanao Yoshihara1, Dr. Michio Kuramochi1, Dr. Hidenori Arai1, Dr. Hiroyuki Nagase1 and Dr. Ken Ohta1,2, 1Teikyo University School of Medicine, Tokyo, Japan, 2National Hospital Organization Tokyo National Hospital, Tokyo, Japan Variation In mRNA Expresion Of GATA1 and PRG2 In Umbilical Cord Blood Following IL-5 Stimulation Ms. Vanessa N. Omana, MSc, Queen’s University, ON, Canada, Mrs. Jenny Thiele, MSc, Queens University, Kingston, ON, Canada and Dr. Anne K. Ellis, MD, MSc FAAAAI, Departments of Medicine and Biomedical & Molecular Science, Queen’s University, Kingston, ON, Canada Mast Cells Drive Tissue Inflammation By Producing IL-33 That Orchestrates a Unique Basophil Phenotype Dr. Chia-Lin Hsu, PhD and Dr. Paul Bryce, PhD, Division of Allergy-Immunology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL Differential Regulation Of Pro-Inflammatory Cytokine Expression Of Airway Smooth Muscle Cells (ASM) By Insulin, Glucose, and Rosiglitazone Dr. Qura-Tul-Ain Rashid, MD, Allergy and Immunology, University of Texas Medical Branch, Dr. Lata Kaphalia, PhD, University of Texas Medical Branch, Galveston and Dr. William J. Calhoun, MD, FAAAAI, Allergy And Immunology, University of Texas Medical Branch, Galveston, TX

SATURDAY

Abstracts AB305

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

Role of Granulocytes and Mast Cells in Mechanisms of Allergic Disease 2213 Saturday, March 1st, 2014, 9:45 AM - 10:45 AM 199

An Association Between Disease Severity and Levels Of LowDensity Granulocytes In The Peripheral Blood Mononuclear Cell Fraction Of Asthma Subjects Dr. Mary C. Tobin, M.D.1,2, Dr. Jun Fu, PhD1, Ms. Paige Adeli, RN1 and Dr. Larry L. Thomas, PhD1, 1Rush University Medical

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Center, Chicago, IL, 2University Consultants in Asthma and Allergy, Chicago, IL Asthma Severity and Expression Of CLC3 On Human Peripheral Blood and Nasal Lavage Eosinophils Devendra K. Agrawal, Rohit Gaurav and Againdra K. Bewtra, Departments of Biomedical Sciences and Internal Medicine, and Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE The Interaction Of Bifidobacteria With Human Blood Leukocytes Dr. Leonid P. Titov, MD, PhD1, Dr. A.S. Murashko2, Dr. Andrei Y. Hancharou3, Dr. N.A. Golovnyova3, Dr. E.I. Kolomiets3 and Prof. Lawrence M. DuBuske, MD, FAAAAI4, 1Republican Scientific and Practical Center for Epidemiology and Microbiology, Minsk, Belarus, 2Republican Scientific And Practical Center for Epidemiology and Microbiology, Minsk, Belarus, 3Republican Scientific and Practical Center for Epidemiology and Microbiology,Minsk, Belarus, 4George Washington University School of Medicine, DC Worldwide Impact Of LAD2 Mast Cell Line On Mast Cell Biology Research Arnold S. Kirshenbaum, MD, FAAAAI1, Amy Petrik, PhD2, Rosemary Walsh, PhD2, Sury Vepa, PhD JD3 and Dean D. Metcalfe, MD, FAAAAI1, 1Laboratory of Allergic Diseases, NIAID, NIH, Bethesda, MD, 2Technology Transfer and Intellectual Property Office, NIAID, NIH, Bethesda, MD, 3Office of Technology Transfer, NIH, Rockville, MD Non c-Kit Tyrosine Kinase Expression In Mast Cell Leukemia Dr. Joseph H. Butterfield, MD, FAAAAI, Mayo Clinic, Rochester, MN Characterization Of Systemic Mastocytosis Patients Based Solely On The Minor Criteria Dr. Anupama Ravi, MD and Dr. Joseph H. Butterfield, MD, FAAAAI, Mayo Clinic, Rochester, MN Basophil Activation Is a Reliable Biomarker Of Allergic Bronchopulmonary Aspergillosis (ABPA) In CF: One Year Results Of a Longitudinal Cohort Study Dr. Yael Gernez, MD, PhD1,2, Mr. Jeffrey Waters2, Mrs. Colleen Dunn2, Zoe Davies2, Dr. Rabindra Tirouvanziam3, Mrs. Cassie Everson2, Dr. John Tamaresis2, Prof. Leonore Herzenberg4 and Dr. Richard B. Moss, MD5, 1Highland Hospital, San Francisco, 2 Stanford University School of Medicine, Stanford, CA, 3Emory University School of Medicine, Department of Pediatrics, Atlanta, GA, 4stanford, School of Medicine, stanford, 5Stanford University School of Medicine, Palo Alto, CA Exosomes Secretion By Eosinophils: A Possible Role In Asthma Pathogenesis Victoria Del Pozo, PhD1, Carla Mazzeo1, Ainara Rodriguez Marco2, Mar Del Mar fERNANDEZ-NIETO3, Maria Paz Zafra4, Veronica Sanz1 and Prof. Joaquin Sastre, MD, PhD, FAAAAI3, 1 IIS-FJD and CIBERES, 2IIS-FJD, 3Fundacion Jimenez Diaz, Madrid, Spain, 4IIS-Fundacion Jimenez Dıaz CD49d-Expressing Neutrophils Are Found In The Nasal Lavage During An Acute Upper Respiratory Illness Dr. Jerome Sigua, MD, Dr. Mitchell H. Grayson, MD, FAAAAI, Dr. Pippa Simpson, PhD, Ms. Erika Buell, Mrs. Desire Hunter and Dr. Dorothy S. Cheung, MD, FAAAAI, Medical College of Wisconsin, Milwaukee, WI Estradiol Has a Negative Impact On The Anaphylactic Response In Mice, Independent From Mast Cell Degranulation Valerie Hox, MD, PhD1,2, Avanti Desai1, Geethani Bandara, PhD1, Alasdair M. Gilfillan, PhD1, Dr. Michael Beaven, PhD3, Dr. Ana Olivera, PhD1 and Dean D. Metcalfe, MD, FAAAAI1, 1Laboratory of Allergic Diseases, NIAID, NIH, Bethesda, MD, 2Laboratory of Clinical Immunology, Department of Microbiology and Immunology, KULeuven, Leuven, Belgium, 3Laboratory of Molecular Immunology, NHLBI, NIH, Bethesda, MD

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Regulation Of Reactive Oxygen Species Production Involving Src Family Kinase In Siglec-8 Induced Eosinophil Cell Death Dr. Gen Kano, MD, PhD, Kyoto Prefectural University of Medicine, Kyoto, Japan, Bruce S. Bochner, MD, FAAAAI, Division of Allergy and Clinical Immunology, Northwestern University School of Medicine, Chicago, IL and Dr. Nives Zimmermann, MD, FAAAAI, Children’s Hospital Medical Center, Cincinnati, OH Ragweed Pollen Extract (RWPE)-Induces TLR4-Dependent Neutrophil Recruitment That Augments Allergic Airway Inflammation Dr. Koa Hosoki, MD, PhD, Dr. Leopoldo Aguilera-Aguirre, PhD, Prof. Istvan Boldogh, PhD, Dr. Qian Sun, PhD and Prof. Sanjiv Sur, MD, University of Texas Medical Branch, Galveston, TX LAMP1 and CD63 Expression In Mouse Mast Cells and Human Basophils Rendered Hyporesponsive By Antigen/IgE-Mediated Activation and Desensitization Prof. Pedro Giavina-Bianchi, MD, PhD, FAAAAI1, Dr. Matthieu Picard, MD2, Dr. Joana Caiado, MD2, Dr. Veronica Mezzano, MD2 and Dr. Mariana C. Castells, MD, PhD, FAAAAI2, 1Clinical Imunnology and Allergy Division, University of Sao Paulo, Boston, MA, 2 Division of Rheumatology, Allergy and Immunology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA Vectorial Exposure and Fusion Of Secretory Granule Content At The Mast Cell Degranulatory Synapse Dr. Nicolas Gaudenzio1, Mr. Regis Joulia2, Prof. Salvatore Valitutti2 and Dr. Eric Espinosa2, 1Stanford University, Stanford, CA, 2 INSERM U1043, Toulouse, France Airway Tissue, But Not Luminal, Eosinophilia Is Related To The Magnitude Of Airway Hyperresponsiveness In a Transgenic Murine Model Of Cat Allergy Mr. Daniel M. Moldaver1, Dr. Mantej S. Bharhani1, Ms. Jennifer Wattie1, Ms. Tarandeep Singh1, Ms. Melissa Babra1, Dr. Marianne van Hage, MD2, Dr. Mark D. Inman, MD, PhD1 and Dr. Mark Larche, PhD1, 1McMaster University, Hamilton, ON, Canada, 2Karolinska Institutet, Department of Medicina Solna, Clinical Immunology and Allergy Unit, Stockholm, Sweden IgE–Mediated Mast Cell Responses Are Inhibited By ThymolMediated Activation-Induced Cell Death Dr. Joshua B. Wechsler, MD1, Dr. Chia-Lin Hsu, PhD2 and Dr. Paul Bryce, PhD2, 1Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 2Division of Allergy-Immunology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL Mechanisms Of Non-IgE-Mediated Uptake Of Antigen By Human Mast Cells Dr. Brant Ward, MD, PhD, Ms. Sahar Lotfi-Emran and Dr. Lawrence B. Schwartz, MD, PhD, FAAAAI, Virginia Commonwealth University, Richmond, VA Human EMR1, An Eosinophil-Specific Surface Receptor Of Unknown Function, Is Modulated In Vivo and In Vitro Dr. Fanny Legrand1, Dr. Nenad Tomasevic2, Mrs. Michelle Makiya1, Dr. Christopher Bebbington2 and Dr. Amy D. Klion, MD1, 1 National Institutes of Health, Bethesda, MD, 2Allakos Cyclo-Oxygenase Inhibition Increases The Frequency Of CD49d+ Neutrophils In The Bronchoalveolar Lavage (BAL) During a Respiratory Viral Infection Ms. Jennifer A. Hass, Ms. Erika Buell, Mrs. Desire Hunter, Dr. Dorothy S. Cheung, MD, FAAAAI and Dr. Mitchell H. Grayson, MD, FAAAAI, Medical College of Wisconsin, Milwaukee, WI High Blood Eosinophils Predict Reductions In Sputum Mast Cells and Lung Function In Response To Triamcinolone In Asthma Dr. Merritt L. Fajt, MD1, Ms. Crystal Uvalle, BS1, Mr. John Trudeau, BA1 and Sally E. Wenzel, MD, FAAAAI2, 1The University of Pittsburgh Asthma Institute at UPMC and the University of Pittsburgh School of Medicine, Department of Pulmonary, Allergy

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and Critical Care Medicine, 2The University of Pittsburgh Asthma Institute at UPMC and the University of Pittsburgh School of Medicine, Department of Pulmonary, Allergy and Critical Care Medicine, Pittsburgh, PA Analyses Of IL-33-Producing Cells During Multiple Antigen Challenges In Murine Asthma Dr. Takeshi Nabe1, Mr. Hiroki Wakamori1, Ms. Anna Takiguchi1, Mrs. Haruka Kida1, Prof. Susumu Ohya1, Dr. Nobuaki Mizutani2, Prof. Shin Yoshino2 and Prof. David Chaplin3, 1Kyoto Pharmaceutical University, Kyoto, Japan, 2Kobe Pharmaceutical University, Kobe, Japan, 3University of Alabama at Birmingham, Birmingham, AL Repeat Lipopolysaccharide Exposure Is Sufficient To Impair Viral Induced Pro-Atopic, CD49d Expressing Neutrophil Recruitment To The Lung Dr. Wei An, MD1,2, Ms. Jennifer A. Hass2, Ms. Erika Buell2, Mrs. Desire Hunter2, Dr. Dorothy S. Cheung, MD, FAAAAI2 and Dr. Mitchell H. Grayson, MD, FAAAAI2, 1Froedtert Hospital, Milwaukee, WI, 2Medical College of Wisconsin, Milwaukee, WI Important Role For Mast Cells But Not Basophils In An Adjuvant-Free Model Of Active Anaphylaxis In Mice Dr. Laurent L. Reber, PhD1, Dr. Hajime Karasuyama, MD, PhD2, Dr. Mindy Tsai, DMSc1 and Dr. Stephen J. Galli, MD1, 1Stanford University School of Medicine, Stanford, CA, 2Tokyo Medical and Dentistry Graduate School, Tokyo, Japan Functional Phenotype Of CD49d-Expressing Neutrophils Differs Between Viral Infection and TLR Stimulation Dr. Dorothy S. Cheung, MD, FAAAAI, Erika Buell, Mrs. Desire Hunter and Dr. Mitchell H. Grayson, MD, FAAAAI, Medical College of Wisconsin, Milwaukee, WI Mast Cells Preferentially Migrate To Denatured Collagens Compared To Native Collagens Thomas Kaido1, Robert T. Reid1, Anthony Montgomery2 and Richard Reid1, 1The Banck Center, San Diego, CA, 2University of California San Diego, San Diego, CA Expression Of The Transcription Factor E4BP4 In Human Basophils Dr. Bettina M. Jensen, Mrs. Maria Gohr and Prof. Lars K. Poulsen, PhD FAAAAI, Allergy Clinic, Copenhagen University Hospital Gentofte, Hellerup, Denmark Cross-Talk Between Human Mast Cells and Bronchial Epithelial Cells In The Production Of Plasminogen Activator Inhibitor-1 Via TGF-b1 Dr. Seong Ho Cho, MD1, Dr. Sun Hye Lee, PhD1, Dr. Atsushi Kato, PhD2, Dr. Tetsuji Takabayashi, MD1, Dr. Soon Shin1 and Dr. Robert P. Schleimer, PhD FAAAAI1, 1Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Department of Medicine, Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL

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Hospital of Chicago, Chicago, IL; Division of Allergy & Immunology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL Epinephrine Use In Positive Oral Food Challenges Performed As Screening For Food Allergy Therapeutic Trials Ms. Sally A. Noone, RN MSN CCRC1, Jaime Ross, RN2, Hugh A. Sampson, MD, FAAAAI3 and Dr. Julie Wang, MD, FAAAAI2, 1 Icahn School of Medicine at Mount Sinai, New York, NY, 2The Icahn School of Medicine at Mount Sinai, New York, NY, 3Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY School Experience With Food Allergy Reactions Highlight The Need For Training and Availability Of Epinephrine Mrs. Katherine A. Schmeissing, MS, R.N.1, Christine Szychlinski, APN, CPNP2, Dr. Jacqueline Pongracic, MD, FAAAAI1,3 and Dr. Anne Marie Singh, MD4, 1Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 2Division of Allergy & Immunology, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 3Division of Allergy & Immunology, Department of Pediatrics,Northwestern University Feinberg School of Medicine, 4 Division of Allergy & Immunology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL Early and Significant Improvement In The Intensity Of Allergic Rhinitis Symptoms After Treatment With Intranasal Ciclesonide 200 Mcg Qd: Open Trial In Mexican Population Francisco Javier Saynes-Marin1, Araceli Arellano-Plancarte2, Jazmin Chiu-Ugalde2, Estefania Torres-Medina2, Jose Antonio Vargas-Romero2 and Juan Carlos Lopez-Alvarenga2,3, 1Hospital Angeles Metropolitano, Mexico City, Mexico, 2Medical Department, Takeda Mexico S.A. de C.V., Edo. de Mex., Mexico, 3Direccion de Investigacion, Hospital General de Mexico ‘‘Eduardo Liceaga’’, Mexico City, Mexico Viral Induced Ibuprofen Sensitivity Leading To Anaphylaxis In Preschool Aged Children Mrs. Jodi A. Shroba, RN MSN CPNP and Ms. Kathryn Chojnacki, Children’s Mercy Hospital Anthropomorphic Variations According To Clinical Pattern In Cow’s Milk Allergic Children Ms. Diana Colson1, Prof. Nicolas Kalach, MD, Ph D2, Ms. Pascale Soulaines3 and Prof. Christophe Dupont, MD, PhD3,4, 1Nutricia opital Saint Vincent de Nutrition Clinique, Saint Ouen, France, 2H^ Paul, Groupement des Hospitaux de l’Institut Catholique de Lille (GH-ICL), Lille, France, 3Hopital Necker Enfants Malades, Paris, France, 4DBV Technologies, Paris, France Development and Piloting Of a Food Allergy Education Program For Parents Of Young Children Ms. Catherine Gillespie, RN MN CAE1, Ms. Nancy Ross, RN CAE1, Dr. Nestor F. Cisneros, MD FRCPC2 and Dr. Allan Becker, MD FRCPC3, 1Children’s Hospital, Winnipeg, MB, Canada, 2University of Manitoba, Winnipeg, MB, Canada, 3University Of Manitoba, Winnipeg, MB, Canada The Proficiency Status In The Use Of Inhaler and The Effect Of Education On Inhaler Technique Eun-Jung Jo, MD1, Jung-Ha Mok, MD1, Seung-Eun Lee, MD2, Mi-Hyun Kim, MD1, Kwangha Lee, MD, PhD1, Ki-Uk Kim, MD, PhD1, Min-Ki Lee, MD, PhD1 and Hye-Kyung Park, MD, PhD1, 1Department of Internal Medicine, Pusan National University School of Medicine, Busan, South Korea, 2Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, South Korea The Natural History Of Wheat Hypersensitivity In Thai Children Dr. Nunthana Siripipattanamongkol, MD, Mahidol university, Bangkok, Thailand Development Of a Multidisciplinary Clinic To Improve Care Of Adolescent Asthmatic Patients Ms. Lila C. Kertz, MSN RN CPNP AE-C, Washington University, St. Louis, MO

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Food Allergy Herbal Formula-2 (FAHF-2) – Adherence To Treatment Jaime Ross, RN1, Suzanne K. Carlisle, RN BSN CCRP2, Maripaz Vazquez, RN, BSN, CDE3, Stacie M. Jones, MD4, Dr. Jacqueline Pongracic, MD, FAAAAI5 and Dr. Julie Wang, MD, FAAAAI1, 1The Icahn School of Medicine at Mount Sinai, New York, NY, 2University of Arkansas for Medical Sciences, Little Rock, AR, 3Division of Allergy and Immunology, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, Chicago, IL, 4Slot 512-13, University of Arkansas for Medical Sciences, Little Rock, AR, 5Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL Adapting Waiting-List For Allergy By Health Care On-Line: Coordination Between Providers and Allergist In The Public System Dr. Inmaculada Sanchez-Machın, MD1, Dr. Paloma Poza Guedes2, Dr. Ruperto gonzalez Perez1, Dr. Yvelise Barrios, MD, PhD3 and Dr. Victor Matheu, MD1, 1Hospital del Torax-Ofra, Sta Cruz de Tenerife, Spain, 2Hospital Ofra-Torax, santa cruz de tenerife, Spain, 3Hospital Universitario de Canarias, Tenerife, Spain Aerobiology Of Texas Panhandle and Efficiency Of AHPCO Technology As Air Purifier, Surface Sterilizer In Food Processing Dr. Nabarun K. Ghosh, PhD1, Dr. Constantine K. Saadeh, MD, FAAAAI2, Dr. Jeff Bennert, PhD CTN3 and Ms. Griselda Estrada, BS1, 1West Texas A&M University, Canyon, TX, 2Allergy ARTS ACCR, Amarillo, TX, 3AIR OASIS, Amarillo, TX

J ALLERGY CLIN IMMUNOL FEBRUARY 2014

L.K. Znamenska1 and Prof. Lawrence M. DuBuske, MD, FAAAAI2, 1Crimean State Medical University, Ukraine, 2George Washington University School of Medicine, DC

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IL-33 and IL1RL1 Single Nucleotide Polymorphisms and Their Association With Asthma Among Puerto Ricans Dr. Javier A. Mendez, MD, Dr. Sylvette Nazario, MD, Dr. Angel Laureano, MD, Dr. Adriana Baez, PhD and Ms. Bianca Rivera, PhDc, University of Puerto Rico School of Medicine, San Juan, PR Genetic Effect Of Single-Nucleotide Polymorphisms In The PPARGC1B Gene On Airway Hyperreactivity In Asthmatic Patients Dr. Jong-Sook Park, MD, Dr. Myung-Sin Kim, Dr. Sung-Woo Park, Dr. An-Soo Jang and Dr. Choon-Sik Park, MD, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea Polymorphisms In IL10, TGFB, TLR4, TLR8 and ADBR2 Genes Resulted Associated To Asthma In Brazilian Family Trio Study Mrs. Isabel Rugu^e Genov, MD, Federal University of S~ao Paulo, S~ao Paulo, Brazil, Mrs. Angela Falcai, PhD, ICB USP, S~ao Paulo, Brazil, Dr. Lucila Camargo, MD, UNIFESP, S~ao Paulo, Brazil, Dr. Marcia Mallozi, MD, Federal University of S~ao Paulo, Brazil, Dr. Virginia Ferriani, MD, PhD, School of Medicine of Ribeirao PretoUniversity of Sao Paulo, Brazil, Prof. Alessandra Pontillo, PhD, University of S~ao Paulo, Brazil, Prof. Antonio Condino-Neto, MD, PhD, Institute of Biomedical Sciences, Department of Immunology, University of S~ao Paulo, Sao Paulo, Brazil and Prof. Dirceu Sole, MD, PhD, Federal University of Sao Paulo, Sao Paulo, Brazil Genetic Variation Along The Histamine Pathway In Children With Allergic Vs. Non-Allergic Asthma Dr. Sara Anvari, MD1, Dr. Carrie A. Vyhlidal, PhD2, Mo Rezaiekhaligh, MS2, Dr. Hongying Dai, PhD2 and Dr. Bridgette L. Jones, MD, FAAAAI1,2, 1Children’s Mercy Hospital & Clinics, Division of Allergy, Asthma and Immunology, Kansas City, MO, 2Children’s Mercy Hospital & Clinics, Division of Pediatric Clinical Pharmacology, Kansas City, MO Association Of Polymorphism At The CD14 Promoter (CD14C159T) With Atopic and Non-Atopic Asthma In Adults From Crimea, Ukraine Dr. Yuri Bisyuk1, Prof. V.A. Beloglazov1, Dr. A.I. Dubovyi1, Dr.

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The Utility Of Anti-Pneumococcal Antibody Measurement In Patients With Primary Immunodeficiency Receiving Immunoglobulin Dr. Stephen Jolles, Dr. Adrian Heaps, Dr. Mo Moody and Dr. Rachel Jones, University Hospital of Wales, Cardiff, United Kingdom Diagnostic Immunization With Bacteriophage FX 174 In Patients With Common Variable Immunodeficiency/Hypogammaglobulinemia Dr. Lauren Smith, MD1, Dr. Rebecca H. Buckley, MD, FAAAAI1 and Dr. Patricia L. Lugar, MD, MS2, 1Department of Pediatrics, Duke University Medical Center, Durham, NC, 2Duke University Medical Center, Durham, NC Immunochip Study Reveals Regions On Chromosomes 2 and 6 May Contribute To The Spectrum Of CVID Dr. Tracy Hwangpo, MD/PhD1, Ewa Szymanksa, PhD1, Mrs. Marsha Brand1, Dr. Peter Gregerson, MD2, Dr. Peter Burrows, PhD3, Dr. Elizabeth Brown, PhD4, Dr. Richard Reynolds, PhD5 and Dr. Harry Schroeder, MD/PhD6, 1UAB, 2The Feinstein Institute for Medical Research, 3UAB, Department of Microbiology, 4UAB,Department of Epidemiology, 5UAB, Department of Medicine, 6UAB, Department of Medicine and Department of Microbiology, AL Rule Of Different Memory Cells In Common Variable Immunodeficiency and Specific Antibody Deficiency Amer M. Khojah, MD, Umm Al Qura Univirsity, Makkah, Saudi Arabia; Inova Fairfax Hospital for children, Fall Church, VA, Oral Alpan, MD, Amerimmune, LLC, VA; O&O ALPAN, LLC and Ameera Bukhari, MS, Taif University, Saudi Arabia Evaluation of a Novel Missense Activation-Induced Deaminase AID Mutation in a Child with Hyper IgM Syndrome: Is it a Pathogenic Mutation? Dr. Ottavia M. Delmonte, M.D., Pediatric Residency Program, Boston Children’s Hospital, Harvard Medical School, Boston, MA, Dr. Feilong Meng, PhD, Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine and Immune Disease Institute, Boston Children’s Hospital, Department of Genetcis, Harvard Medical School, Boston, MA, Dr. Frederick Alt, PhD, Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine and Immune Disease Institute, Boston Children’s Hospital, Department of Genetics, Harvard Medical School, Boston, MA, Dr. Luigi D. Notarangelo, MD, Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA; The Manton Center for Orphan Disease Research, Boston Children’s Hospital, Boston, MA and Dr. Jolan E. Walter, MD, PhD, Division of Allergy/Immunology, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA

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Surfactant Protein A (SP-A) Reduces Human Rhinovirus 16 (RV16)-Induced Inflammatory Responses In Bronchial Epithelial Cells and Inhibits Viral Replication In H1-HeLa Cells Sasipa Tanyaratsrisakul, PhD1, Ying Wang, MD2, Monica Kraft, MD2, Mari Nakamura, MD1 and Prof. Dennis R. Voelker, PhD1,

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Department of medicine, National Jewish Health, Denver, CO, 2Department of Medicine, Duke University Medical Center, Durham, NC The Home Microbiome and Childhood Asthma Dr. Christina E. Ciaccio, MD, FAAAAI, Mr. Kevin Kennedy, MPH CIEC, Prof. Charles S. Barnes, PhD, Dr. Jay M. Portnoy, MD, FAAAAI and Dr. Lanny J. Rosenwasser, MD, FAAAAI, Children’s Mercy Hospital, Kansas City, MO Effect Of Prenatal Antioxidant Intake On Infants’ Respiratory Infection Dr. Eun Lee1, Seo Ah Hong2, Dr. Song I Yang, MD1, Prof. Kyung Won Kim, MD, PhD3, Prof. Youn Ho Shin4, Kang Mo Ahn5, Dr. Soo-Jong Hong, MD, PhD1 and And the COCOA study group, 1Department of Pediatrics, Childhood Asthma Atopy Center, Research Center for Standization of Allergic Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, 2Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea, 3Department of Pediatrics, Severance Children’s Hospital, College of Medicine, Yonsei University, Seoul, Korea, Seoul, South Korea, 4Department of Pediatrics, CHA Medical Center, CHA University School of Medicine, Seoul, Korea, South Korea, 5 Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, South Korea Epidermal Growth Factor Receptor (EGFR) Mediates Cell Fusion and Infectivity Of Respiratory Syncytial Virus (RSV) Sujin Lee1,2, Michael G. Currier1,2, Anne L. Hotard1,2, Jia Meng1,2, Carla Pretto1,2, Ultan F. Power3, Remi Villenave3, Michael D. Shields3,4, Michael H. Chi5, R. Stokes Peebles6 and Martin L. Moore1,2, 1Department of Pediatrics, Emory University, GA, 2Children’s Healthcare of Atlanta, GA, 3Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Science, Queens University Belfast, Northern Ireland, 4The Royal Belfast Hospital for Sick Children, Northern Ireland, 5Allergy, Pulmonary, and Critical Care Medicine; Department of Medicine; Vanderbilt University School of Medicine, TN, 6Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN Cluster Analysis Of An Inner-City Cohort Of Infant Wheezers Dr. Monica B. Reddy, MD1, Andrew H. Liu, MD2, Allison Schiltz1,2, Mrs. Anna Forssen, MS2 and Dr. Mary D. Klinnert, PhD1,2, 1University of Colorado School of Medicine, 2National Jewish Health, Denver, CO

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A Randomized, Multi-Center, NIH/NIAID Funded Study To Assess The Immunogenicity Of Fluzone Intradermal and Intramuscular Vaccines In Atopic Dermatitis Donald Y.M. Leung, MD, PhD, FAAAAI1, Lisa A. Beck, MD, FAAAAI2, Dr. Jon M. Hanifin, MD, FAAAAI3, Dr. Lynda C. Schneider, MD, FAAAAI4, Dr. Amy Paller, MD5, Dr. Gloria David, PhD6, Ms. Katherine Monti6, Mr. Brett Jepson6 and Dr. Adriana Weinberg, MD7, 1National Jewish Health, Denver, CO, 2University of Rochester Medical Center, Rochester, NY, 3Oregon Health & Science University, Portland, OR, 4Boston Children’s Hospital, Boston, MA, 5Northwestern University Feinberg School of Medicine, Chicago, IL, 6Rho, Inc., Chapel Hill, NC, 7University of Colorado Heath Sci Ctr., Denver, CO Which Infants With Eczema Are At Risk Of Food Allergy? Results From A Population Based Study Dr. Jana K. Eckert, PhD1, Dr. Pamela Martin, PhD1, Dr. Adrian Lowe, PhD1,3, Dr. Jennifer Koplin, PhD1, Prof. Shyamali Dharmage, MD, PhD1,3, Prof. Lyle Gurrin, PhD1,3, Prof. Mimi L. K. Tang, MD,

PhD, FAAAAI4, Prof. Anne-Louise Ponsonby, PhD1, Dr. Melanie Matheson, PhD3, Dr. David Hill, MBBD, FRACP1 and Prof. Katrina Jane Allen, MD, PhD, FAAAAI1,5, 1Murdoch Childrens Research Institute, Victoria, Australia, 3University of Melbourne, Victoria, Australia, 4The University of Melbourne, Melbourne, Australia, 5Royal Children’s Hospital, Victoria, Australia Exome Chip Genotyping Reveals Association With PDE4C and Atopic Dermatitis In Populations Of European and African Descent Nicholas M. Rafaels1, Lili Huang, MPH1, Donald Y.M. Leung, MD, PhD, FAAAAI2, Lisa A. Beck, MD, FAAAAI3, Dr. Candelaria I. Vergara, MD, PhD1, Dr. Mark Boguniewicz, MD, FAAAAI2, Dr. Tissa Hata, MD4, Dr. Lynda C. Schneider, MD, FAAAAI5, Dr. Jon M. Hanifin, MD, FAAAAI6, Dr. Richard Gallo, MD, PhD7, Dr. Li Gao, MD, PhD1, Dr. Ingo Ruczinski, PhD8, Dr. Rasika A. Mathias, ScD1 and Dr. Kathleen C. Barnes, PhD FAAAAI1, 1Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, MD, 2National Jewish Health, Denver, CO, 3 University of Rochester Medical Center, Rochester, NY, 4University of California, San Diego, San Diego, CA, 5Boston Children’s Hospital, Boston, MA, 6Oregon Health & Science University, Portland, OR, 7Division of Dermatology, University of California, San Diego, San Diego, CA, 8Johns Hopkins University School of Public Health, Baltimore, MD Exploring a Role for Laminin Proteins in the Pathogenesis of Atopic Dermatitis Erin J. Klaffky, MD, PhD, Rachana Agrawal, PhD and Judith A. Woodfolk, MBChB, PhD, FAAAAI, University of Virginia, Charlottesville, VA Thymic Stromal Lymphopoietin and Interleukin-33 Promote Skin Inflammation and Containment Of Vaccinia Virus In A Mouse Model Of Atopic Dermatitis Dr. Michiko K. Oyoshi, PhD, MSc, Ms. Jacqueline Beaupre, Mr. Nicholas Venturelli and Raif S. Geha, MD, Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA

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Abstracts AB309

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What Really Happens In The Home: The Medication Environment Of Urban, Minority Youth Dr. Molly Martin, MD, MAPP and Andrea A Pappalardo, MD, Rush University Medical Center, Chicago, IL Young, African American Adults With Asthma: What Matters To Them? Dr. Aimee L. Speck, M.D.1, Dr. Belinda Nelson, PhD2, Mrs. S. Olivia Jefferson, MSW3 and Dr. Alan P. Baptist, MD, MPH FAAAAI1, 1University of Michigan, Division of Allergy and Clinical Immunology, Ann Arbor, MI, 2University of Michigan, Health Behavior and Health Education, School of Public Health, Ann Arbor, MI, 3University of Michigan, Department of Health Behavior and Health Education, School of Public Health, Ann Arbor, MI Language Disparities Among Minority Patients with Poor Asthma Control Dr. Jose R. Zaragoza-Buxo, MD, Penn State University College of Medicine, Hershey, PA and Dr. Efren L. Rael, MD, FAAAAI, Allergy/Immunology, Penn State University College of Medicine, Hershey, PA Race/Ethnicity and SES Are Predictors Of Allergic Sensitization To Environmental and Food Allergens Dr. Amina Abdeldaim, MD1, Dr. Supinda Bunyavanich, MD, MPH2, Ms. Sheryl Rifas-Shiman, MPH3, Thomas A.E. Platts-Mills, MD, PhD, FAAAAI4, Dr. Diane R. Gold, MD, MPH5, Dr. Carlos

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Camargo Jr., MD, DrPH6, Dr. Emily Oken, MD7, Dr. Matthew Gillman, MD, SM3 and Dr. Augusto A. Litonjua, MD, MPH8, 1Channing Division of Network Medicine, Brigham and Women’s Hospital, MA, 2Division of Pediatric Allergy & Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 3Harvard Medical School, Boston, MA, 4Division of Asthma, Allergy & Immunology, University of Virginia Health System, Charlottesville, VA, 5Channing Laboratory, Brigham and Women’s Hospital, Boston, MA, 6Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 7Harvard Medical School, 8Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA Unrecognized Allergic Rhinoconjunctivitis and Allergic Sensitization Among Latino Youth (GALA II Study) Ulysses Burley, MPH1, Dr. Joy Hsu, MD, MSCI2, Duanny Alva, MD-IMG, MPH1, Ms. Elizabeth Nguyen, BS3, Ms. Lindsey Roth, MA4, Dr. Joshua Galanter, MD4, Dr. Sam Oh, PhD, MPH4, Ms. Celeste Eng, BS4, Mr. Fred Lurmann, MS5, Dr. Rajesh Kumar, MD, MS, FAAAAI6, Dr. Harold J. Farber, MD, MSPH7, Dr. Denise Serebrisky, MD8, Dr. Luisa Borrell, DDS, PhD9, Dr. Saunak Sen, PhD10, Dr. William Rodriguez-Cintron, MD11, Dr. Jose RodriguezSantana, MD12, Dr. Esteban Gonza Burchard, MD, MPH4 and Prof. Pedro C. Avila, MD, FAAAAI1, 1Feinberg School of Medicine, Northwestern University, Chicago, IL, 2Department of Medicine, Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Department of Medicine, University of California, San Francisco, California, San Francisco, CA, 4Department of Medicine, University of California, San Francisco, San Francisco, CA, 5Sonoma Technology, Inc., Petaluma, CA, 6Pediatric allergy, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 7Baylor College of Medicine and Texas Children’s Hospital, Houston, TX, 8Pediatric Pulmonary Division, Jacobi Medical Center, Bronx, NY, 9Department of Health Sciences, Graduate Program in Public Health, Lehman College, City University of New York, Bronx, NY, 10Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 11Veterans Caribbean Health Care System, San Juan, PR, 12Centro de Neumologia Pediatrica, San Juan, PR

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Mechanisms of Steroid and Arachidonic Acid Pathways in Allergic Disease 2607 Saturday, March 1st, 2014, 2:00 PM - 3:15 PM 269

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Local Allergic Rhinitis and Non-Allergic Rhinitis 2606 Saturday, March 1st, 2014, 2:00 PM - 3:15 PM 264

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The Nasal NO Response To External Acoustic Energy: A Pilot Study Dennis Shusterman, MD, MPH, University of California, San Francisco, Richmond, CA Flagellin/Toll-Like Receptor 5 Induces Interleukin-17C In Human Nasal Epithelia Dr. Hyun Jin Min1, Dr. Tae-Hoon Kim2, Su-Yeon Choi2, Prof. JooHeon Yoon1,2 and Prof. Chang-Hoon Kim1,3, 1Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea, 2Research Center for Human Natural Defense System, Yonsei University College of Medicine, Seoul, South Korea, 3The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, South Korea Phenotyping Non-Allergic and Local Allergic Rhinitis Dr. Carmen Rondon, MD, PhD1, Dr. Paloma Campo, MD, PhD1, Dr. Esther Barrionuevo Sanchez, MD1, Ms. Cristina De Leiva Molina1, Dr. Leticia Herrero Lifona, MD, PhD1, Ms. Maria Auxiliadora Guerrero1, Dr. Francisca Gomez, MD, PhD1, Dr. Natalia BlancaLopez, MD, PhD2, Dr. Gabriela Canto, MD, PhD2 and Dr. Miguel Blanca, MD, PhD1, 1Allergy Service, Carlos Haya Hospital, Malaga, Spain, 2Allergy Service, Infanta Leonor Hospital, Madrid, Spain

Role Of Basophil Activation Test For Identifying Subjects With Local Allergic Rhinitis Dr. Paloma Campo, MD, PhD1, Dr. Carmen Rondon, MD, PhD1, Dr. Enrique Gomez, PhD2, Dr. Esther Barrionuevo Sanchez1, Mrs. Luisa Galindo, RN1, Mr. JA Huertas1, Dr. Cristobalina Mayorga, PhD2 and Dr. Miguel Blanca, MD, PhD1, 1Allergy Service, Carlos Haya Hospital, Malaga, Spain, 2Research Laboratory for Allergic Diseases, Hospital Regional Universitario de Malaga - IBIMA, Malaga, Spain Does Serum Leptin Differ Between Patients With Rhinitis Of Allergic Vs Nonallergic Aetiology? Prof. Ayse Fusun Kalpaklioglu, MD and Dr. Ayse Baccioglu, MD, Kirikkale University Faculty of Medicine Department of Allergic Diseases

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LTC4, But Not LTD4 Or LTE4, Activates Platelets Through a CysLT2R and P2Y12 Receptor-Dependent Pathway Dr. Joshua A. Boyce, MD, FAAAAI1,2, Dr. Tao Liu, PhD1,2 and Dr. Hannah Cummings, PhD1,2, 1Harvard Medical School, Boston, MA, 2Brigham and Women’s Hospital, Division of Rheumatology, Immunology and Allergy, Boston, MA Predictors Of Response To Glucocorticoids In Hypereosinophilic Syndromes Paneez Khoury, MD1, Annalise Abiodun, RN1, Kelli Williams, MD, M.P.H.1, JeanAnne Ware, CRNP1, Nicole Holland-Thomas, MSN, RN2 and Dr. Amy D. Klion, MD1, 1National Institutes of Health, Bethesda, MD, 2SAIC-Frederick Inc., Bethesda, MD Differential Proteomic Analysis Of Eosinophils From Patients With Glucocorticoid Responsive Or Resistant Hypereosinophilic Syndrome Konrad Pazdrak, MD, PhD1, Paneez Khoury, MD2, Kizhake V. Soman, PhD1, Nicole Holland-Thomas, MSN, RN3, Mrs. Michelle Makiya2, Christof Straub, PhD1, Zheng Wu, PhD1, Dr. Amy D. Klion, MD2 and Alexander Kurosky, PhD1, 1University of Texas Medical Branch, Galveston, TX, 2National Institutes of Health, Bethesda, MD, 3SAIC-Frederick Inc., Bethesda, MD Glucocorticoid Receptor-^ a Up-Regulation In C57BL/6 Diet-Induced Obese Mice With House Dust Mite-Mediated Asthma Dr. Jennifer Diaz, MD1,2, Dr. Malvika Solanki, MBBS, MPH3, Dr. Xiangying Xue, MD3, Prodyot Chatterjee, PhD3, Dr. Madhu Gupta, MBBS3, Dr. Vincent R. Bonagura, MD, FAAAAI4 and Christine Metz, PhD3, 1Feinstein Institute for Medical Research, Manhasset, NY, 2Allergy and Immunology, North Shore-LIJ Health System, Great Neck, NY, 3Feinstein Institute for Medical Research, NY, 4 Division of Allergy/Immunology, Departments of Medicine and Pediatrics, Hofstra North Shore-LIJ School of Medicine, Great Neck, NY Reduced EP2 Receptor Expression Accounts For Prostaglandin E2 Resistance In Nasal Polyp Fibroblasts From Patients With Aspirin Exacerbated Respiratory Disease; Possible Role For Histone Acetylation In Control Of EP2 Receptor Expression Dr. Katherine N. Cahill, MD1,2, Mr. Derek Thibault3, Dr. Benjamin A. Raby, MD, MPH3, Dr. Andrea Baccarelli, MD, MPH PhD4, Dr. Neil Bhattacharyya, MD2,3, Dr. Joshua A. Boyce, MD, FAAAAI1,2 and Dr. Tanya M. Laidlaw, MD, FAAAAI1,2, 1Brigham and Women’s Hospital, Division of Rheumatology, Immunology and Allergy, Boston, MA, 2Harvard Medical School, Boston, MA, 3 Brigham and Women’s Hospital, Boston, MA, 4Harvard School of Public Health, Boston, MA

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Association Between Body Mass Index (BMI) and Fraction Of Exhaled Nitric Oxide (FeNO) Levels In The National Health and Nutrition Examination Survey (NHANES) 2007-2010 Dr. Sindhura Gogineni, MD, Dr. Joseph Espiritu and Dr. Aditya Uppalapati, MD, St. Louis University, St. Louis, MO 275 Daily Global Stress Is Associated With Nocturnal Awakenings Due To Asthma In School-Age Children Dr. Caroline C. Horner, MD, FAAAAI1, Courtney Dula, MS1, Dr. Leonard B. Bacharier, MD, FAAAAI2, Dr. Jane Garbutt, MBChB1, Dr. Robert C. Strunk IV, MD, FAAAAI1, Mr. Carlos Gonzalez, MS1, Ms. Elena Deych, MS1 and Dr. William Shannon, PhD1, 1 Washington University School of Medicine, Saint Louis, MO, 2Department of Pediatrics, Washington University School of Medicine and St. Louis Children’s Hospital, Saint Louis, MO A Seven Minute High Intensity Workout Is Well Tolerated In Adults With Asthma and Results In Decreased Salivary Leukotrienes Dr. Katherine G. Conner, MD1, Dr. Meaghan Misiasz, M.D.1, Dr. Maria Talamo2, Ms. Caitlin Campion1, Julie McDaniel1, Dr. Jun Fu, PhD1 and James N Moy, MD1,2, 1Rush University Medical Center, Chicago, IL, 2John H. Stroger Hospital of Cook County, Chicago, IL Obesity and Depression Affecting Asthma Morbidity: An Analysis Of Montefiore Asthma Center’s Poorly Controlled Asthmatics Dr. Sunit Jariwala, MD1, Dr. Jennifer Toh, MD1 and Dr. Sumita Sinha, MD2, 1Albert Einstein/Montefiore Medical Center, New York, NY, 2Albert Einstein/Montefiore Medical Center, Bronx, NY Psycho Social Stresses and Asthma Morbidity In Children Dr. Ejaz Yousef, MD FAAAI, Marshfield Clinic, Marshfield, WI; Marshfield Clinic, Marshfield, WI Does The Sinusitis Affect Bronchial Hyperresponsiveness In Asthmatic Children ? Chikako Motomura, Dr. Hiroshi Odajima, Yuko Amimoto, Rintaro Ono, Keisuke Watanuki, Yoko Murakami, Naohiko Taba, Satoshi Honjho and Sankei Nishima, Fukuoka National Hospital, Fukuoka, Japan Allergic Bronchopulmonary Mycosis. Are We Overdiagnosing In Cape Town, South Africa? Dr. Tamara Kerbelker, MBChB, Red Cross War Memorial Children’s Hospital, Cape Town, South Africa Risk Factors For Postoperative Pulmonary Complications After Noncardiothoracic Surgery In Adult Asthma Patients Seung-Eun Lee, MD1,2, Eun-Jung Jo, MD2, Hye-Kyung Park, MD2, Woo-Hyeon Cho, MD1,2, Doo-Soo Jeon, MD1,2 and Prof. Yun-Seong Kim, MD1,2, 1Respiratory and allergy clinic, Pusan National University Yangsan Hospital, South Korea, 2Department of Internal Medicine, Pusan National University School of Medicine, South Korea Rates Of Comorbidities Are Related To Level Of Asthma Control Dr. Mark Stevens, MD1, Dr. Jeffrey R. Stokes, MD, FAAAAI1, Ryan Walters, M.S.2, Dr. Michael Schatz, MD, MS, FAAAAI3 and Dr. Thomas B. Casale, MD, FAAAAI4, 1Creighton University Medical Center, Omaha, NE, 2Creighton University, 3Kaiser Permanente Southern California, San Diego, CA, 4Univeristy Of South Florida Morsani College Of Medicine, Tampa, FL Rates Of Co-Morbidities Are Related To Asthma Severity Dr. Jeffrey R. Stokes, MD, FAAAAI1, Dr. Mark Stevens, MD1, Ryan Walters, M.S.2, Dr. Michael Schatz, MD, MS, FAAAAI3 and Dr. Thomas B. Casale, MD, FAAAAI4, 1Creighton University Medical Center, Omaha, NE, 2Creighton University, 3Kaiser Permanente Southern California, San Diego, CA, 4Univeristy Of South Florida Morsani College Of Medicine, Tampa, FL

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Exercise-Induced Bronchospasm In Adolescents: Characteristics Of Lung Function and Accuracy Of Symptoms Mr. Daniel Andrade Hygidio1, Ms. Beatriz Schwinden1, Dr. Paulo Freitas1 and Dr. Jane Da Silva1,2, 1University of Southern Santa Catarina - UNISUL, Tubar~ao - SC, Brazil, 2Hospital Universit!ario Polydoro Ernani de S~ao Thiago - HU/UFSC, Florian! opolis - SC, Brazil Variation Of Bronchial Hyperresponsiveness According To Age and Gender In Pediatric Population Dr. Young Ho Kim, MD1, Dr. Eun Lee, MD2, Dr. Song I Yang, MD2, Dr. Young Ho Jung, MD2, Dr. Hyung Young Kim, MD3, Dr. Ju-Hee Seo, MD4, Dr. Byoung-Ju Kim, MD, PhD5, Dr. HyoBin Kim, MD, PhD6, Prof. So Yeon Lee, MD, PhD7, Prof. Dae Jin Song, MD, PhD8, Prof. Woo Kyung Kim, MD, PhD9, Dr. Gwang Cheon Jang, MD, PhD10, Prof. Jung Yeon Shim, MD, PhD11, Prof. Jinho Yu, MD, PhD2, Prof. Soo-Jong Hong, MD. PhD12 and Dr. Ji-Won Kwon, MD13, 1Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, South Korea, South Korea, 2Childhood Asthma Atopy Center, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea, 3Department of Pediatrics, Kosin University Gospel Hospital, Kosin University College of Medicine, Seoul, South Korea, 4Department of Pediatrics, Korea Cancer Center Hospital, Seoul, South Korea, 5Department of Pediatrics, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea, 6Department of Pediatrics,Inje University Sanggye Paik Hospital, Seoul, South Korea, 7Department of Pediatrics, Hallym University College of Medicine, Seoul, South Korea, 8Department of Pediatrics, Korea University Guro Hospital, Seoul, South Korea, 9Department of Pediatrics, Seoul Paik Hospital, Inje University College of Medicine, Seoul, South Korea, 10Department of Pediatrics, National Health Insurance Corporation Ilsan Hospital, Seoul, South Korea, 11Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, South Korea, 12Research Center for Standardization of Allergic Disease, University of Ulsan College of Medicine, Seoul, Korea, 13 Department of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea Nasal Provocation Test In The Diagnosis Of Mite Allergic Rhinitis : Standard Or Rapid ? Prof. Frederic de BLAY, Dr. Celine Lutz, Dr. Mael Bellier, Prof. Jean Jacques Braun and Mrs. Brigitte Sbinne, CHRU Strasbourg, France Nocturnal Asthma In Latino Children Is Associated With Severe Disease and Allergenic Triggers (GALA II Study) Dr. Geeta Bhargave, MD1, Dr. Joy Hsu, MD, MSCI1, Ms. Elizabeth Nguyen, BS2, Ms. Lindsey Roth, MA3, Dr. Joshua Galanter, MD3, Dr. Sam Oh, PhD, MPH3, Ms. Celeste Eng, BS3, Mr. Fred Lurmann, MS4, Dr. Harold J. Farber, MD, MSPH5, Dr. Denise Serebrisky, MD6, Dr. Luisa Borrell, DDS, PhD7, Dr. Saunak Sen, PhD8, Dr. William Rodriguez-Cintron, MD9, Dr. Jose RodriguezSantana, MD10, Dr. Esteban Gonza Burchard, MD, MPH3 and Prof. Pedro C. Avila, MD, FAAAAI1, 1Feinberg School of Medicine, Northwestern University, Chicago, IL, 2Department of Medicine, University of California, San Francisco, California, San Francisco, CA, 3Department of Medicine, University of California, San Francisco, San Francisco, CA, 4Sonoma Technology, Inc., Petaluma, CA, 5Baylor College of Medicine and Texas Children’s Hospital, Houston, TX, 6Pediatric Pulmonary Division, Jacobi Medical Center, Bronx, NY, 7Department of Health Sciences, Graduate Program in Public Health, Lehman College, City University of New York, Bronx, NY, 8Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 9Veterans Caribbean Health Care System, San Juan, PR, 10Centro de Neumologia Pediatrica, San Juan, PR

SUNDAY

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Nasal Challenge With 50mgs Of L-Aspirin For Diagnosis Of ASA Exacerbated Respiratory Disease Dr. Jose Manuel Reyna Guerra, MD, National Institute Of Respiratory Diseases, Distrito Federal, Mexico Clinical Usefulness Of Bronchial Mannitol Provocation Test In Children With Asthma Symptoms Dr. Young A. Park, MD1, Hyun Bin Park, MD1, Dr. Yoon Hee Kim, MD1, Dr. Hee Seon Lee, MD1, Dr. Yoon Ki Han, MD1, Dr. Min Jung Kim, MD1, Hye Mi Jee, MD2, Prof. Kyung Won Kim, MD, PhD1, Prof. Myung Hyun Sohn, MD, PhD1 and Prof. Kyu-Earn Kim, MD, PhD1, 1Department of Pediatrics, Severance Children s Hospital, College of Medicine, Yonsei University, Seoul, Korea, Seoul, South Korea, 2Department of Pediatrics, CHA University School of Medicine, Seongnam, Korea, South Korea Salivary Alpha Amylase Activity Is a Potential Surrogate Biomarker For Inhaled Beta-2 Agonist Responsiveness Andrea A Pappalardo, MD1,2, Jamie H Kiehm, MD1, Caitlin M Campion1, Dr. Larry L. Thomas, PhD1 and James N Moy, MD1,2, 1 Rush University Medical Center, Chicago, IL, 2John H. Stroger Hospital of Cook County, Chicago, IL Feno Decreases Significantly During Improved Symptom Control In Pediatric Patients After Acute Asthma Exacerbations Necessitating Emergency Department Care Dr. Eric M. Karlin, MD, Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, Tebeb Gebretsadik, MPH, Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, and Center for Asthma and Environmental Sciences Research, Vanderbilt University School of Medicine, Nashville, TN, Dr. Emily W. Langley, MD, Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, Dr. Tina V. Hartert, MD, MPH, Vanderbilt University School of Medicine, Nashville, TN, Dr. R. Stokes Peebles Jr., MD, FAAAAI, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN and Dr. Donald H. Arnold, MD, MPH, Center for Asthma and Environmental Health Sciences Research, Vanderbilt University School of Medicine, Nashville, TN; Departments of Pediatrics and Emergency Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee Risk Factors Of High Feno Levels & Cut-Off Value Of Feno In Elementary School Children With Asthma Dr. Hyun Ju Cho, MD1, Dr. Young-Ho Ho Jung, MD1,2, Dr. Eun Lee, MD1,3, Dr. Song I Yang, MD1,4, Dr. Hyung Young Kim, MD4,5, Dr. Ju-Hee Seo, MD6,7, Dr. Ji-Won Kwon, MD4,8, Dr. Byoung-Ju Kim, MD, PhD9,10, Dr. Hyo-Bin Kim, MD, PhD11,12, Prof. So Yeon Lee, MD, PhD12,13, Prof. Dae Jin Song, MD, PhD4,14, Prof. Woo-Kyung Kim, MD, PhD2,15, Dr. Gwang Cheon Jang, MD, PhD4,16, Prof. Jung Yeon Shim, MD, PhD4,17 and Dr. Soo-Jong Hong, MD, PhD1,2, 1Childhood Asthma Atopy Center, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea, 2Research Center for Standardization of Allergic Disease, Seoul, South Korea, 3childhood Asthma atopy center , asan medical center, University of Ulsan College of Medicine, South Korea, 4Research Center for Standardization of Allergic Diseases, Seoul, South Korea, 5Department of Pediatrics, Kosin University Gospel Hospital, Kosin University College of Medicine, Seoul, South Korea, 6Department of Pediatrics, Korea Cancer Center Hospital, Seoul, South Korea, 7Department of pediatrics, Korea Cancer Center Hospital, South Korea,

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8 Department of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea, 9Department of Pediatrics, Hae-undae Paik Hospital, Inje University College of Medicine, Busan, South Korea, 10 Department of Pediatrics, Hae-undae Paik Hospital, Inje University College of Medicine, 11Department of Pediatrics,Inje University Sanggye Paik Hospital, Seoul, South Korea, 12Research Center for Standardization of Allergic Diseases, Seoul, South Korea, South Korea, 13Department of Pediatrics, Hallym University College of Medicine, Seoul, South Korea, 14Department of Pediatrics, Korea University Guro Hospital, Seoul, South Korea, 15Department of Pediatrics, Seoul Paik Hospital, Inje University College of Medicine, Seoul, South Korea, 16Department of Pediatrics, National Health Insurance Corporation Ilsan Hospital, Seoul, South Korea, 17 Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, South Korea Metabolomic Profiles Of Exhaled Breath Condensate In Asthmatics Dr. Sandra Ho, MD1, Dr. Bruce Luxon, PhD1, Dr. Wendy Baker, PhD1, Dr. Heidi Spratt, PhD1, Dr. Rohit Divekar, MBBS, PhD2, Emily Aaron1 and Dr. William J. Calhoun, MD, FAAAAI1, 1Institute of Translational Sciences, University of Texas Medical Branch, Galveston, TX, 2Division of Allergic Diseases, Mayo Clinic, Rochester, MN Extended Nitric Oxide Analysis and Bronchial Hyperresponsiveness In Children With Asthma According To Atopy Dr. Yoon Hee Kim, MD, Dr. Min Jung Kim, MD, Dr. Hee Seon Lee, MD, Dr. Yoon Ki Han, MD, Dr. Young A. Park, MD, Prof. Kyu-Earn Kim, MD, PhD, Prof. Kyung Won Kim, MD, PhD and Prof. Myung Hyun Sohn, MD, PhD, Department of Pediatrics, Severance Children’s Hospital, College of Medicine, Yonsei University, Seoul, Korea, Seoul, South Korea Reference Values and Determinants Of Fractional Concentration Of Exhaled Nitric Oxide (FeNO) In Healthy Children Dr. Young Ho Jung, MD1,2, Dr. Hyun Ju Cho, MD1, Dr. Ji-Won Kwon, MD2,3, Dr. Song I Yang, MD1,2, Dr. Eun Lee, MD1,4, Dr. Hyung Young Kim, MD2,5, Dr. Ju-Hee Seo, MD6,7, Dr. ByoungJu Kim, MD, PhD8,9, Dr. Hyo-Bin Kim, MD, PhD9,10, Prof. So Yeon Lee, MD, PhD9,11, Prof. Dae Jin Song, MD, PhD2,12, Prof. Woo Kyung Kim, MD, PhD2,13, Dr. Gwang Cheon Jang, MD, PhD2,14, Prof. Jung Yeon Shim, MD, PhD2,15 and Prof. Soo-Jong Hong, MD. PhD2,16, 1Childhood Asthma Atopy Center, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea, 2Research Center for Standardization of Allergic Diseases, Seoul, South Korea, 3Seoul National University Bundang Hospital, Seoul National University College of Medicine, 4childhood Asthma atopy center , asan medical center, University of Ulsan College of Medicine, South Korea, 5Department of Pediatrics, Kosin University Gospel Hospital, Kosin University College of Medicine, Seoul, South Korea, 6Department of Pediatrics, Korea Cancer Center Hospital, Seoul, South Korea, 7Department of pediatrics, Korea Cancer Center Hospital, South Korea, 8 Department of Pediatrics, Hae-undae Paik Hospital, Inje University College of Medicine, Busan, South Korea, 9Research Center for Standardization of Allergic Diseases, Seoul, South Korea, South Korea, 10Department of Pediatrics,Inje University Sanggye Paik Hospital, Seoul, South Korea, 11Department of Pediatrics, Hallym University College of Medicine, Seoul, South Korea, 12Department of Pediatrics, Korea University Guro Hospital, Seoul, South Korea, 13 Department of Pediatrics, Seoul Paik Hospital, Inje University College of Medicine, Seoul, South Korea, 14Department of Pediatrics, National Health Insurance Corporation Ilsan Hospital, Seoul, South Korea, 15Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, South Korea, 16Childhood Asthma Atopy Center, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, South Korea

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Improvement Of FENO In Youth With Asthma After Attending An Asthma Summer Camp Dr. Jonathan A. Olsen, DO1, Dr. Mark Stevens, MD1, Mr. Patrick Foster, B.S.2 and Dr. Russell Hopp, DO, FAAAAI3, 1Creighton University Medical Center, Omaha, NE, 2American Lung Association, Omaha, NE, 3Creighton University School Medicine, Omaha, NE Exhaled Nitric Oxide (FeNO) and T-Helper 2 Cell Biomarkers: Can They Predict Treatment Response To Dupilumab, An IL4Ra Antibody, In An Eosinophilic Asthma Population? Brian N. Swanson, PhD1, Lin Wang, PhD1, Jeffrey Ming, MD1, Jennifer D. Hamilton, PhD2, Ariel Teper, MD1, Thomas Dicioccio, PhD2, Yongtao Li, PhD1, Dr. Neil Graham, MD2, Dr. Gianluca Pirozzi, MD, PhD1 and Sally E. Wenzel, MD, FAAAAI3, 1Sanofi, Bridgewater, NJ, 2Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 3University of Pittsburgh Medical Center NW, Pittsburgh, PA Asthma Management Costs With Feno In Addition To Standard Guidelines Dr. Glenn Crater, MD1, Dr. Craig F. LaForce, MD, FAAAAI2, Ms. Nancy Herje, BSN, RN, MBA1, Dr. Elizabeth Brooks, PhD3 and Dr. Kathy Rickard, M.D.1, 1Aerocrine, Inc., Morrisville, NC, 2North Carolina Clinical Research, Raleigh, NC, 3Reimbursement Principles, Highlands Ranch, CO Developmental Assessment Of Serum Periostin As An Asthma Biomarker In Children Dr. Halie M. Anderson1, Dr. Robert F. Lemanske Jr., MD, FAAAAI2, Joseph R. Arron3, Cecile Holweg4, Ms. Victoria Rajamanickam5, Dr. James E. Gern, MD, FAAAAI2 and Dr. Daniel J. Jackson, MD6, 1University of Wisconsin, Madison, WI, 2University of Wisconsin School of Medicine and Public Health, Madison, WI, 3 Genentech, Inc., South San Francisco, CA, 4Genentech, Inc, South San Francisco, CA, 5University of Wisconsin Hospitals and Clinics, 6 Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI

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T-Cell Profiles In Bronchoalveolar Lavage (BAL) Of Wheezing Children With and Without A History Of Respiratory Syncytial Virus (RSV) Lower Respiratory Tract Infection Dr. Chang-Kuen Kim, MD, FAAAAI, Asthma & Allergy Center, Inje University Sanggye Paik Hospital, Seoul, South Korea, Dr. JinTack Kim, MD, PhD, Department of Pediatrics, Uijeongbu St. Mary’s Hospital, The Catholic University of Korea, College of Medicine, Uijeongbu, Gyeonggi-Do, South Korea, Sally E. Wenzel, MD, FAAAAI, University of Pittsburgh Medical Center NW, Pittsburgh, PA and Dr. Marzena E. Krawiec, MD, National Jewish Medical and Research Center, Denver, CO Increased Blood Th2-Like Invariant Natural Killer T Cells In Patients With Asthma Prof. Young-Il Koh, MD and Jae-Uoong Shim, Chonnam National University Medical School Establishment and Treatment Of a Steroid Resistant Asthma Model By Adoptive Transfer Of Helper T Cell Clones Dr. Akio Mori, MD, PhD1, Mr. Satoshi Kouyama, MSc1, Ms. Miyako Yamaguchi1, Ms. Yo Iijima1, Dr. Jun Itoh, MD1, Dr. Hiroaki Hayashi, MD1, Dr. Takafumi Minami, MD1, Dr. Kentaro Watarai, MD1, Dr. Chihiro Mitsui, MD1, Dr. Chiyako Oshikata, MD1, Dr. Hidenori Tanimoto, MD1, Dr. Yuma Fukutomi, MD1, Dr. Kiyoshi Sekiya, MD1, Dr. Takahiro Tsuburai, MD, PhD1, Dr. Masami Taniguchi, MD, PhD1, Dr. Yuji Maeda, MD1, Dr. Mamoru Ohtomo, MD1, Dr. Maki Hasegawa, MD, PhD1, Dr. Kazuo Akiyama,

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MD1 and Dr. Osamu Kaminuma, PhD2, 1National Hospital Organization, Sagamihara National Hospital, Sagamihara, Japan, 2Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan CD4+ T Cells From Nasal Polyp Explants Contain Abundant Th2 Cells Expressing Functional Interleukin-25 Receptors Together With Th17 Cells Mrs. Emily Lam, MSc1, Dr. Harsha H. Kariyawasam, MD, PhD2, Prof. Stephen R. Durham, MA MD FRCP3, Ms. Joanne Rimmer, FRCS(ORL-HNS)2, Dr. Valerie J. Lund, MD2, Dr. David Cousins, PhD1 and Dr. Stephen Till, MD, PhD1, 1King’s College London, London, United Kingdom, 2Royal National Throat, Nose & Ear Hospital London, University College London, London, United Kingdom, 3Imperial College London, London, United Kingdom Successful Desensitization To Paclitaxel For Stage 4 Ovarian Cancer Dr. Erica T. Gastelum, MD, UCSF Fresno, Madera, CA, Kush Das, Baz Allergy, Asthma & Sinus Center, Fresno, CA, Dr. Praveen Buddiga, MD, FAAAAI, University of California San FranciscoFresno, Fresno, CA; Baz Allergy Asthma & Sinus Center, Fresno, CA and Dr. Malik N. Baz, MD, UCSF-Fresno, Fresno, CA; Baz Allergy Asthma and Sinus Center, Fresno, CA IL-17 Plays a Major Role In Driving The Recruitment Of B Cells Into Bronchial Tissue Of Asthmatic Patients Dr. S Al-Muhsen, MD, King Saud University, College of Medicine, Riyadh, Saudi Arabia, Mrs. Mary -Angeline Pureza, King Saud University, Riyadh, Saudi Arabia, Dr. Qutayba Hamid, MD, PhD, FAAAAI, McGill University Health Centre, Montreal, QC, Canada and Dr. Rabih Halwani, PhD, King Saud University, college of Medicine, Riyadh, Saudi Arabia A Comparison Of Asthma Prevalence and Severity Among Urban and Rural African American Teenage Youth Dr. Dennis Ownby, M.D. FAAAAI1, Dr. Martha Tingen, PhD2, Ms. Suzanne Havstad, M.A.3, Dr. Jennifer Waller, PhD2, Dr. Christine Cole Johnson, PhD MPH FAAAAI3 and Dr. Christine L.M. Joseph, PhD3, 1Division of Allergy-Immunology and Rheumatology, Georgia Health Sciences University, Augusta, GA, 2Georgia Regents University, Augusta, GA, 3Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI Interleukin-4 and Transforming Growth Factor-Beta Single Nucleotide Genes Polymorphisms Confer Susceptibility To Atopic Dermatitis Dr. Nima Rezaei, MD, PhD1,2, Ms. Zahra Aryan2,3, Dr. Nasrin Behniafard, MD4, Ms. Elham Farhadi, MSc5, Dr. Soheila Sotoudeh, MD4, Dr. Mojdeh Khaledi, MD6, Dr. Maryam Mahmoudi, MD7, Prof. Asghar Aghamohammadi8, Prof. Ali Akbar Amirzargar, PhD2 and Dr. Mohammad Gharagozlou, MD4, 1Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Tehran, Iran, 2Molecular Immunology Research Center; and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, 3Student Scientific Research Center (SSRC), School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, 4Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Tehran, Iran, 5Hematology Department, School of Allied Medical Science, Tehran University of Medical Sciences, Tehran, Tehran, Iran, 6Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Tehran, Iran, 7School of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Tehran, Iran, 8Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran A Comparison Of Regulatory T-Cell Receptor Vb (3,5) Expression In Patients With Food Allergy and Atopic Dermatitis Benjamin Prince, MD1,2, Kristin A. Erickson1, Christine Szychlinski, APN, CPNP2, Miao Cai, MS2 and Dr. Anne Marie Singh, MD1,3, 1Northwestern University Feinberg School of Medicine, Chicago, IL, 2Division of Allergy & Immunology, Ann & Robert

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H. Lurie Children’s Hospital of Chicago, Chicago, IL, 3Division of Allergy & Immunology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL Correlation Between Fractional Exhaled Nitric Oxide and Asthma Exacerbation Dr. Nawinda Mahawichit, MD, Mahidol University, Bangkok, Thailand IL17RB+ Granulocytes In Asthma Patients Dr. Lin Li, MD1, Dr. Matthew A. Schaller, PhD2, Dr. Alan P. Baptist, MD, MPH FAAAAI1 and Dr. Nicholas W. Lukacs, PhD3, 1University of Michigan, Division of Allergy and Clinical Immunology, Ann Arbor, MI, 2University of Michigan, Department of Pathology, Ann Arbor, MI, 3University of Michigan, Ann Arbor, MI Pollen From Genetically Modified Bt Maize Does Not Promote Allergic Responses In Mice Mrs. Monica Andreassen1,2, Dr. Elena Rocca3, Dr. Thomas Bøhn3,4, Dr. Odd-Gunnar Wikmark3, Prof. Johnnie Van den Berg5, Prof. Martinus Lovik2, Prof. Terje Traavik3,4 and Dr. Unni C. Nygaard2, 1GenØk - Centre for Biosafety, Tromso, Norway, 2 Norwegian Institute of Public Health, Oslo, Norway, 3GenØk Centre for Biosafety, Norway, 4University of Tromsø, Norway, 5 North-West University, Potchefstroom, South Africa Effects Of rs3744262 On DNA Methylation and Symptoms In Participants With Allergic Rhinitis During Grass Pollen Exposure In The Environmental Exposure Unit (EEU) Dr. Michelle North, PhD1, Ms. Sarah Mah, BSc.2, Mr. Andrew G. Day, MSc3, Dr. Michael Kobor, PhD2,4 and Dr. Anne K. Ellis, MD, MSc FAAAAI1,5, 1Departments of Medicine and Biomedical & Molecular Science, Queen’s University, Kingston, ON, Canada, 2 Centre for Molecular Medicine & Therapeutics, Child & Family Research Institute, Vancouver, BC, Canada, 3Clinical Research Centre, Kingston General Hospital, Kingston, ON, Canada, 4University of British Columbia, Vancouver, BC, Canada, 5Allergy Research Unit, Kingston General Hospital, Kingston, ON, Canada Chronic Spontaneous Urticaria – An Evaluation Of An Indirect Immunofluorescence Method For Detecting Anti-Mast Cell IgG Antibodies Bahar Bahrani, Natasha Gattey and Peter Hull, University of Saskatchewan, Canada Protease Activity Of Per a 10 Causes CD 40 Cleavage On Dendritic Cells and Th2 Polarization Ms. Komal Agrawal, MSc, CSIR-IGIB, DELHI, India and Dr. Naveen Arora, Ph.D, CSIR Institute of Genomics and Integrative Biology, New Delhi, India Type 2 Immunity Can Have a Protective Role In Host Defense Against Venoms In Mice Dr. Thomas Marichal, DVM PhD1, Dr. Philipp Starkl, PhD1, Dr. Laurent Reber, PhD1, Dr. Janet Kalesnikoff, PhD1, Dr. Hans C. Oettgen, MD, PhD, FAAAAI2, Dr. Mindy Tsai, DMSc1, Dr. Martin Metz, MD, PhD3 and Dr. Stephen J. Galli, MD1, 1Stanford University School of Medicine, Stanford, CA, 2Boston Children’s Hospital, Boston, MA, 3Charite Campus Mitte, Berlin, Germany CD4+ and CD8+ T Cells Bearing Na€ıve and Memory Markers In Blood Of Immigrants To Brooklyn Who Develop Asthma and Allergic Disease Dr. Ashlei Mathew, MD1,2, Dr. Irina Katayeva, MD1,3, Seto Chice, MS1,4, Dr. Stephan Kohlhoff, MD1,5, Dr. Rauno O. Joks, MD, FAAAAI1,2, Dr. Helen G. Durkin, PhD1,4 and Dr. Maria-Anna Vastardi, MD1,3, 1Center for Allergy and Asthma Research, State University of New York Downstate Medical Center, Brooklyn, NY, 2 Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, NY, 3Lutheran Medical Center, Brooklyn, NY, 4Department of Pathology, State University of New York Downstate Medical Center, Brooklyn, NY, 5Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY

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17b-Estradiol Increases IL-17A Protein Expression From Mouse CD4+ Th17 Differentiated Cells Jacqueline-Yvonne Cephus, BS1, Dr. Dawn C. Newcomb Baker, PhD2, Madison Boswell1, Kasia Goleniewska3 and Dr. Ray Peebles, MD1, 1Allergy, Pulmonary, and Critical Care Medicine; Department of Medicine; Vanderbilt University School of Medicine, Nashville, TN, 2Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, Nashville, TN, 3Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 17-b Estradiol Positively Correlates With IL-17A+ CCR6+ Memory CD4+ T Cells In Patients With Severe Asthma Dr. Dawn C. Newcomb Baker, PhD1,2, Jacqueline-Yvonne Cephus, BS3, Dr. Emily W. Langley, MD4, Amy S. Feldman, MD5, Mrs. Nanalene Frey6, Ms. Kristen Cooper6, Dr. John M. Fahrenholz, MD, FAAAAI7 and R. Stokes Peebles8, 1Vanderbilt University School of Medicine, Nashville, TN, 2Medicine, Vanderbilt University Medical Center, Nashville, TN, 3Allergy, Pulmonary, and Critical Care Medicine; Department of Medicine; Vanderbilt University School of Medicine, Nashville, TN, 4Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, 5Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, and Center for Asthma and Environmental Sciences Research, Vanderbilt University School of Medicine, Nashville, TN, 6Vanderbilt University Medical Center, 7 Vanderbilt University Medical Center, Nashville, TN, 8Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN Allergic Sensitization and Determination Of Serum Eosinophil Cationic Protein and Triptase In Preschool Population In Hermosillo, Sonora, Mexico Dr. Claudia Gallego-Corella1, Dr. Guadalupe Corella2, Ms. Andrea Romo3, Prof. Antonio Rasc!on4 and Mr. Pablo Mart!ınez3, 1 Medicine Faculty, Xochicalco University, Tijuana, Mexico, 2 Health, Nutrition and Environment, Department of Chemical and Biological Sciences, University of Sonora, Mexico, Hermosillo, Mexico, 3Department of Chemical and Biological Sciences, University of Sonora, Mexico, Hermosillo, Mexico, 4Health, Nutrition and Environment, Department of Chemical and Biological Sciences,University of Sonora, Mexico, Hermosillo, Mexico Fungal Cross-Allergenicity In Specific Ige Testing Dr. Mercedes C. Amado, MD, FAAAAI1, Dr. Jay M. Portnoy, MD, FAAAAI2 and Dr. Charles Barnes, PhD2, 1Children’s Mercy Hospital, Shawnee Mission, KS, 2Children’s Mercy Hospital, Kansas City, MO Monocytes From Peanut-Allergic Patients Express Higher Levels Of RALDH2 In Response To Peanut Protein Than Monocytes From Tolerant Subjects Elizabeth Fleming, BS1, Bert Ruiter, PhD1, Barry K. Hurlburt, PhD2, Soheila J. Maleki, PhD2 and Wayne G. Shreffler, MD, PhD, FAAAAI1, 1Massachusetts General Hospital, Boston, MA, 2 USDA-ARS-SRRC, New Orleans, LA Peanut Protein Induces Expression Of RALDH2 In Human Dendritic Cells In a TLR2-Dependent Manner Bert Ruiter, PhD1, Elizabeth Fleming, BS1, Barry K. Hurlburt, PhD2, Soheila J. Maleki, PhD2 and Wayne G. Shreffler, MD, PhD, FAAAAI1, 1Massachusetts General Hospital, Boston, MA, 2 USDA-ARS-SRRC, New Orleans, LA IL-4 Receptor Alpha and STAT6 Single Nucleotide Polymorphisms Are Associated With Increased Risk Of Asthma In a Saudi Arabian Population Dr. Rabih Halwani, PhD1, Dr. Alejandro Vazquez-Tello2, Mr. Amer Jamhawi2, Dr. Hamdan Jahdali3 and Dr. Saleh Al-Muhsen, MD4, 1 King Saud University, college of Medicine, Riyadh, Saudi Arabia, 2 King Saud University, Riyadh, Saudi Arabia, 3King Saud University

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Infants With Idiopathic T Cell Lymphopenia Identified On New York State Newborn Screen: A Follow Up Report Dr. Stephanie Albin, MD1, Dr. Harshna Mehta, MD1 and Dr. Charlotte Cunningham-Rundles, MD, PhD, FAAAAI2, 1The Icahn School of Medicine at Mount Sinai, New York, NY, 2Mt. Sinai Medical Center, New York, NY Frequency Of Cellular and Humoral Immunodeficiencies In Digeorge Syndrome Patients Seen At New York Presbyterian Columbia Between 2006-2012 Dr. Collette Spalding, MD1, Dr. Kyung Hwa Jung, PhD1, Dr. Rachel L. Miller, MD, FAAAAI1 and Dr. Yesim Demirdag, MD2, 1Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, New York, NY, 2Department of Pediatric Allergy/Immunology, Columbia University, New York, NY A Novel ORAI1 Mutation Resulting In T+B+NK+ SCID With Normal Lymphocyte Proliferation Janet S. Chou, MD1, Christina S.K. Yee, MD, PhD1, Mr. Wayne Bainter, BS1, Dr. Luigi D. Notarangelo, M.D.2, Dr. Suleiman M. S. E. Al-Hammadi, MD, FAAAAI3 and Raif S. Geha, MD1, 1Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, 2Stem Cell Institute, Boston, MA, 3FMHS, UAE University, Al-Ain, United Arab Emirates Coronin-1A Oligomerization Is Critical For Host Defense Against Viral Pathogens Christina S.K. Yee, MD, PhD1, Ozden Sanal, MD2, Janet S. Chou, MD1, Raif S. Geha, MD1, Deniz Ayvaz, MD3, Caner Aytekin, MD3 and A. Nurten Akarsu, MD, PhD4, 1Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, 2Department of Pediatrics, Hacettepe University Ihsan Dogramaci Children’s Hospital, Ankara, Turkey, 3Department of Pediatric Immunology, Dr Sami Ulus Maternity and Children’s Research and Educational Hospital, Ankara, Turkey, 4Department of Medical Genetics, Hacettepe University Ihsan Dogramaci Children’s Hospital, Ankara, Turkey Newborn Screening For Severe Combined Immunodeficiency In Iowa: TREC Assay Results and Characteristics Of SCID and TCell Lymphopenic Patients Farheen Mirza, MD1, Emily Phillips, RN BSN CCRC1, Travis Henry, PhD1 and Dr. Mary Beth Fasano, MD, FAAAAI2, 1University of Iowa, 2C42-E6 GH, University of Iowa College Medicine, Iowa City, IA Thymus Graft Factors Critical For Negative Selection Of Direct Allospecific T Cells Dr. Ivan K. Chinn, MD, Dr. Ivo D. Shterev, PhD, Kristina J. Riebe and Dr. Douglas C. Rouse, DVM, Duke University Medical Center, Durham, NC Successful Hematopoietic Stem Cell Transplant For CD40 Deficiency Manifesting As Hyper-IgM Syndrome With Absent CD40 Expression and Marked Lymphocytosis Dr. Joyce Hsu, MD, Medicine, Boston Children’s Hospital, Boston, MA, Dr. Michel Massaad, PhD, Boston Children’s Hospital and Dr. Luigi D. Notarangelo, MD, Stem Cell Institute, Boston, MA IL-2 Receptor Gamma-Chain(IL2RG) Defect Can Present With Features Other Than Increased Susceptibility To Infection Dr. Bob Geng, MD1, Dr. Maria Garcia-Lloret, MD, FAAAAI2, Dr. Yen Tun Wang, MD3, Dr. Ki-Young Yoo, MD3, Dr. Raymond Barnhill, MD3, Dr. Derek Wong, MD3 and Dr. E. Richard Stiehm, MD, FAAAAI2, 1UCLA, Los Angeles, CA, 2Division of Allergy and

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Abstracts AB315

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

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Study On Air Pollution and Respiratory Health Of Children In Delhi, India Ms. Jincy Mathew, M.Tech, CSIR- Institute of Genomics and Integrative Biology, Delhi, India, Dr. Radha Goyal, Ph.D, CSIR- National Environmental Engineering Research Institute, Delhi, India, Dr. Krinshna K Taneja, Ph.D, CSIR- Istitute of Genomics and Integrative Biology,, Delhi, India and Dr. Naveen Arora, Ph.D, CSIR Institute of Genomics and Integrative Biology, New Delhi, India Trans-Generational Transmission Of Ozone – Induced Airway Dysfunction Prof. Park Choon Sik, Mr. Bae Da-Jeong, Dr. Park Jong-Sook and Dr. Jang An Soo, Soonchunhyang University Bucheon Hospital, Gyeonggi-Do, South Korea Dust Mite Allergen In Bed Dust Predicts Rhinitis Symptom Persistence In Urban Pre-Adolescent Children With Higher Elemental Carbon Particulate Matter Exposure Dr. Young Yoo, MD, PhD1,2, Dr. Luis M. Acosta, MD1, Prof. Inge Goldstein, DrPH3, Prof. Andrew Rundle, DrPH4, Omar Olmedo1,

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Adnan Divjan1, Dr. Beihzhan Yan5, Prof. Judith Jacobson, DrPH4, Dr. Rachel L. Miller, MD, FAAAAI6, Dr. Steven Chillrud5 and Prof. Matthew S. Perzanowski, PhD1, 1Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, 2Department of Pediatrics, College of Medicine, Korea University, Seoul, South Korea, 3Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 4Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 5Lamont-Doherty Earth Observatory, Columbia University, Palisades, NY, 6Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, New York, NY Associations Between Outdoor Of PM2.5 With Cough and Wheeze Symptoms In Asthmatic Children In Korea Prof. Woo Kyung Kim, MD, PhD1,2, Mrs. Young Wook Lee1 and Dr. Hae-Sun Yoon1, 1Allergy & respiratory research laboratory, Inje University College of Medicine, Seoul, South Korea, 2Department of Pediatrics, Seoul Paik Hospital, Inje University College of Medicine, Seoul, South Korea Effect Of Duration Of Residence In Brooklyn On IgE Responses Of Immigrants Dr. Edward Kleiman, MD1, Dr. Maria-Anna Vastardi, MD2,3, Dr. Irina Katayeva, MD2,3, Dr. Helen G. Durkin, PhD2 and Dr. Rauno O. Joks, MD, FAAAAI1, 1SUNY Downstate Medical Center, Center for Allergy and Asthma Research, Brooklyn, NY, 2Center for Allergy and Asthma Research, State University of New York Downstate Medical Center, Brooklyn, NY, 3Lutheran Medical Center, Brooklyn, NY Impact Of Energy Expenditure On Ozone-Induced Inflammation Dr. Krista Todoric, MD1, Dr. Michelle L. Hernandez, MD1, Dr. Haibo Zhou, PhD2 and Dr. David B. Peden, MD, MS, FAAAAI1, 1 University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 2University of North Carolina at Chapel Hill, School of Public Health Exposure Of Mice To Silica Crystals and Poly I:C Synergistically Enhances Neutrophil Infiltration and Epithelial Damage In The Airway Dr. Hirotoshi Unno, M.D., Dr. Hideaki Morita, MD., PhD., Dr. Hirohisa Saito, MD., PhD., Dr. Kenji Matsumoto, MD, PhD and Dr. Akio Matsuda, PhD, Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan Modest Effects Of Bisphenol A Exposure In Mouse Models Of Respiratory Allergy and Food Allergy Dr. Unni C. Nygaard1, Dr. Mari Samuelsen1, Dr. Nina Vinje1, Mrs. Monica Andreassen1,2, Prof. Martinus Lovik1 and Dr. Johanna Bodin1, 1Norwegian Institute of Public Health, Oslo, Norway, 2 GenØk - Centre for Biosafety, Tromso, Norway

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In Vitro Allergy Testing: Relationship Patterns Between Allergen Pairs Dr. John S. Kaptein, PhD1, C.K. Lin, PhD1 and Dr. Bruce J. Goldberg, MD, PhD, FAAAAI2, 1Southern California Permanente Medical Group, Los Angeles, CA, 2Kaiser Permanente, Los Angeles, CA Comparison Of Total Protein Profile Of Alternaria Alternata Extract Obtained From Various U.S. Allergenic Extract Manufacturers Dr. Jay E. Slater, MD1, Ms. Allison Zoch2, Ms. Shoshana Newman-Gerhardt2 and Dr. Taruna Khurana, PhD3, 1FDA/CBER/ OVRR/DBPAP, Rockville, MD, 2FDA/CBER, 3CBER FDA

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IgE Antibodies To Cat and Cat Components In Relation To Asthma In a Population Study Of 963 18 Year Olds From Six Schools In Northern Sweden Ms. Hayley James, BS1, Prof. Matthew S. Perzanowski, PhD2, Eva Ronmark, PhD3, Bo Lundback, MD, PhD3, Jillian Roper1 and Thomas A.E. Platts-Mills, MD, PhD, FAAAAI4, 1University of Virginia, Charlottesville, VA, 2Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, 3Karolinska Institutet, Stockholm, Sweden, 4Division of Asthma, Allergy & Immunology, University of Virginia Health System, Charlottesville, VA Epitope Mapping Of An Anti-Bla g 1 ScFv Used For Cockroach Allergen Quantitation Dr. Geoffrey Mueller, PhD1, Mr. John Ankney2, Dr. Lars Pedersen1, Dr. Taruna Khurana, PhD3, Dr. Jay E. Slater, MD4, Ms. Jill Glesner5, Dr. Anna Pomes, PhD FAAAAI5 and Dr. Robert London1, 1 National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, 2National Intstitute of Environmental Health Sciences, NIH, 3FDA Center for Biologics Evaluation and Research, 4FDA/CBER/OVRR/DBPAP, Rockville, MD, 5Indoor Biotechnologies, Inc., Charlottesville, VA Antigenic Analysis Of The Major Cockroach Allergen Bla g 5 and Its Dust Mite Homolog Der p 8 Ms. Jill Glesner1, Dr. Geoffrey Mueller, PhD2, Dr. Lars Pedersen2, Dr. Martin D. Chapman, PhD FAAAAI1 and Dr. Anna Pomes, PhD FAAAAI1, 1Indoor Biotechnologies, Inc., Charlottesville, VA, 2National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC Immunomodulatory Effects Of Rye Grass Pollen Allergen Lol p 5 On The Prostaglandin E2 Pathway and Kallikrein-Kinin System Of Respiratory Epithelial Cells Cecilia Tong, Alice Vrielink, Martha Ludwig and Geoffrey Stewart, University of Western Australia Development and Characterization Of a Murine Model Of Repeated Dry Exposure To Aerosolized Fungal Conidia Dr. Ajay Nayak, PhD1, Dr. Amanda Buskirk, PhD1,2, Mr. W.Travis Goldsmith3, Ms. Angela Lemons1, Dr. Justin Hettick, PhD1, Dr. Michael Kashon, PhD4, Ms. Amy Cumpston3, Mr. Jared Cumpston3, Mr. Howard Leonard3, Mr. Walter McKinney3, Dr. David Frazer, PhD3, Dr. Donald H. Beezhold, PhD FAAAAI1 and Dr. Brett J. Green, PhD1, 1CDC/NIOSH/ACIB, Morgantown, WV, 2West Virginia University, Morgantown, WV, 3CDC/NIOSH/PPRB, Morgantown, WV, 4CDC/NIOSH/BEB, Morgantown, WV Cross-Reactivity Between Recombinant Tropomyosin From Chortoglyphus and Natural Tropomyosin Of Other Extracts Dr. Jeronimo Carnes1, Dr. M. Angeles Lopez Matas1, Dr. Manuel Boquete, MD2, Dr. Raquel Moya1 and Dr. Victor Miguel Iraola1, 1 Laboratorios LETI, Tres Cantos, Spain, 2Hospital Xeral de Calde, Lugo, Spain Identification Of The Cysteine Protease Amb a x As A Novel Major Allergen From Short Ragweed Pollen (Ambrosia artemisiifolia) Dr. Philippe Moingeon, PhD1, Julien Bouley, PhD2, Maxime Le Mignon, PhD2, Veronique Baron-Bodo, PhD2, Veronique Bordas, PhD2, Laetitia Bussi!eres2, Marie-No€elle Couret3, Aurelie Lautrette, PhD2, Thierry Batard, PhD4, Rachel Groeme2, Henri Chabre, PhD2 and Emmanuel Nony2, 1Stallergenes SA, Antony, France, 2 Stallergenes, France, 3Stallergenes, 4Stallergenes, Antony, France Characterization Of The Allergenic Activity Of Tropomyosin From Aedes Aegypti Mr. Jose F. Cantillo, Complutense University of Madrid, Spain; Inmunotek S.L., Alcala de Henares, Spain, Prof. Leonardo Puerta, Institute for Immunological Research/University of Cartagena, Cartagena, Colombia, Dr. Enrique Fernandez-Caldas, Inmunotek, S.L, Spain and Dr. Sylvie Lafosse-Marin, Cabinet de Inmunoallergology, Fort de France, Martinique

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Peanut Epicutaneous Immunotherapy (EPIT) In Peanut-Allergic Children: 18 Months Treatment In The Arachild Study Prof. Christophe Dupont, MD, PhD1, Dr. Thierry Bourrier2, Prof. Frederic de BLAY3, Dr. Lydie Guenard-Bilbault3, Dr. Christine Sauvage4, Dr. Marie-Odile Cousin4, Dr. Gis!ele Kanny, MD, PhD5, Dr. Sophie Jarlot5 and Dr. Chantal Karila, MD6, 1Hopital Necker Enfants Malades, Paris, France, 2Lenval Hospital, Nice, France, 3CHRU Strasbourg, France, 4Saint Vincent de Paul Hospital, Lille, France, 5CHU Nancy Hopital Central, Nancy, France, 6 Hopital Necker, Paris, France Predictors For Allergic Symptoms During Build-Up and Maintenance Phases Of Oral Immunotherapy To Peanut Dr. Marie M. de Alwis, MD1,2, Dr. Jason Lee, MD, FAAAAI1, Dr. Mitchell R. Lester, MD, FAAAAI1, Dr. Louis M. Mendelson, MD, FAAAAI1, Dr. Glenda Nouman, MD1 and Dr. Jeffrey M. Factor, FAAAAI1, 1New England Food Allergy Treatment Center, West Hartford, CT, 2Connecticut Children’s Medical Center, Hartford, CT Quality Of Life With Sublingual Immunotherapy For Peanut Nicole Leung1, Yamini Virkud, MD, MA2, Pamela H. Steele, MSN CPNP AE-C3, Janet S. Kamilaris, RN4, Edwin Kim, MD, MS5, Brian P. Vickery, MD, FAAAAI3, Dr. Audrey Dunn Galvin6 and A. Wesley Burks, MD, FAAAAI3, 1Duke University, 2Duke University, Durham, NC, 3University of North Carolina, Chapel Hill, NC, 4Carolinas Health Care System, Charlotte, NC, 5University of North Carolina at Chapel Hill, Chapel Hill, NC, 6University College Cork, Cork, Ireland Low Dose Maintenance Peanut Oral Immunotherapy Can Produce Sustained Unresponsiveness Julia A. Cronin, MD, University of Virginia, Division of Asthma, Allergy and Immunology, Charlottesville, VA, Julia Wisniewski, MD, University of Virginia, Division of Pediatric Respiratory Medicine and Allergy, Charlottesville, VA and Scott P. Commins, MD, PhD, University of Virginia Health System, Charlottesville, VA Increases In Peanut-Specific IgA1 and IgA2 During Peanut Immunotherapy Do Not Correlate With Clinical Tolerance Adrienne L. Yancey1, Michael D. Kulis Jr., PhD1, Pamela H. Steele, MSN CPNP AE-C1, Edwin Kim, MD, MS1, Brian P. Vickery, MD, FAAAAI2 and A. Wesley Burks, MD, FAAAAI1, 1University of North Carolina School of Medicine, Chapel Hill, NC, 2 University of North Carolina, Chapel Hill, NC Peanut OIT-Induced IgG Suppresses Ex Vivo Activation Of Allergic Donor Basophils Via a Combination Of Antigen Interception and Receptor-Bound Inhibition Caitlin Burk, Michael D. Kulis Jr., PhD, Edwin Kim, MD, MS, Brian P. Vickery, MD, FAAAAI and A. Wesley Burks, MD, FAAAAI, University of North Carolina at Chapel Hill, Chapel Hill, NC Omalizumab Pretreatment Does Not Protect Against Peanut Oral Immunotherapy-Related Adverse Gastrointestinal Events Uyenphuong Le, MD1, Yamini Virkud, MD, MA2, Brian P. Vickery, MD, FAAAAI1, Pamela H. Steele, MSN CPNP AE-C1, Janet S.

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Kamilaris, RN3, Michael D. Kulis Jr., PhD1, Jelena Berglund, PhD, RAC2 and A. Wesley Burks, MD, FAAAAI1, 1University of North Carolina, Chapel Hill, NC, 2Duke University, Durham, NC, 3Carolinas Health Care System, Charlotte, NC Single Practice Five-Year Experience Treating Food Allergy With Oral Immunotherapy: Efficacy and Epinephrine Treated Reactions Mrs. Angela R. Hague, PA-C, Dr. Richard L. Wasserman, MD, PhD, FAAAAI, Dr. Stacy K. Silvers, MD and Dr. Robert W. Sugerman, MD, FAAAAI, DallasAllergyImmunology, Dallas, TX Single Practice, Five-Year Experience Treating Food Allergy With Oral Immunotherapy (FOIT): Successes and Failures Ms. Dena M. Pence, RT, Mrs. Angela R. Hague, PA-C, Dr. Richard L. Wasserman, MD, PhD, FAAAAI, Dr. Robert W. Sugerman, MD, FAAAAI and Dr. Stacy K. Silvers, MD, DallasAllergyImmunology, Dallas, TX Single Practice Five Year Experience Treating Food Allergy With Oral Immunotherapy (FOIT): Effect On Antigen Specific IgE (asIgE) Dr. Stacy K. Silvers, MD, Mrs. Angela R. Hague, PA-C, Ms. Dena M. Pence, RT, Dr. Robert W. Sugerman, MD, FAAAAI and Dr. Richard L. Wasserman, MD, PhD, FAAAAI, DallasAllergyImmunology, Dallas, TX Secondary Eosinophilic Reactions During ORAL Immunotherapy Prof. Yitzhak Katz, MD, FAAAAI1,2, Dr. Michael Goldberg, MD, PhD2, Dr. Liat Nachshon, MD2, Dr. Marc E. Rothenberg, MD, PhD, FAAAAI3,4, Dr. Miguel Leon Stein, MD, FAAAAI5, Dr. Efrat Broide6,7, Dr. Gratiana Hermann6, Dr. Arnon Elizur, MD1,2 and Dr. Michael B. Levy, MD, FAAAAI2, 1Tel Aviv University, Tel Aviv, Israel, 2Assaf Harofeh, Zerifin, Israel, 3Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 4Children’s Hospital Medical Center, Cincinnati, OH, 5Assaf Harofeh Medical Center, Rehovot, Israel, 6 Assaf Hrofeh Meducal center, Israel, 7Tel-Aviv university Rate Of Anaphylaxis Caused By Oral Immunotherapy In Children With Cow’s Milk Allergy Prof. Giovanni B. Pajno, MD, FAAAAI1, Dr. Giuseppe Crisafulli1,2, Dr. Giuseppina Salzano1,2, Dr. Roberta Vadal!a1,2, Dr. Stefania Arasi1,2, Dr. Salvatore Barberi3 and Dr. Lucia Caminiti1,2, 1 University of Messina, Messina, Italy, 2Dept of Pediatrics, Allergy Unit, University of Messina, 3Pediatric Clinic, San Paolo Hospital, University of Milan, Milan, Italy Long-Term Follow Up In Cow’s Milk Anaphylaxis After Successful Rush Oral Immunotherapy Mrs. Paloma Poza-Guedes, Dr. Ruperto Gonzalez-Perez, Dr. Inmaculada Sanchez-Machın, MD and Dr. Victor Matheu, MD, Hospital del Torax-Ofra, Sta Cruz de Tenerife, Spain Milk Oral Immunotherapy. Standard Versus Personalized Protocols: Efficiency and Safety Alberto Alvarez-Perea, MD, Dr. Elena Alonso-Lebrero, PhD, Fernanda Freire, MD, Dr. Sonsoles Infante, MD, Victoria FuentesAparicio, MD and Lydia Zapatero, MD, Hospital Materno Infantil Gregorio Mara~ non, Pediatric Allergy Department, Madrid, Spain Cross-Desensitization To Goat and Sheep Milk Protein In Cow’s Milk Protein Desensitized Patients Dr. Michael Levy, MD, FAAAAI1, Dr. Liat Nachshon, MD1, Dr. Michael Goldberg, MD, PhD1, Dr. Arnon Elizur, MD1,2 and Prof. Yitzhak Katz, MD, FAAAAI1,2, 1Assaf Harofeh, Zerifin, Israel, 2 Tel Aviv University, Tel Aviv, Israel Long Term Follow Up Of Children Who Incorporated Extensively Heated (baked milk) In The Diet Dr. Anna H. Nowak-Wegrzyn, MD, FAAAAI1, Mrs. Beth D. Strong, RN CCRC2, Ms. Diane Ananos1 and Hugh A. Sampson, MD, FAAAAI3, 1Icahn School of Medicine at Mount Sinai, New York, NY, 2Icahn School of medicine at Mount Sinia, New York, NY, 3Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY

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Abstracts AB317

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

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Baked Milk Oral Immunotherapy For Severe IgE-Mediated Cow’s Milk Protein (CMP) Allergic Patients: Interim Results Dr. Michael Goldberg, MD, PhD1, Dr. Liat Nachshon, MD1, Dr. Arnon Elizur, MD2, Dr. Moshe Appel3, Dr. Michael B. Levy, MD, FAAAAI1 and Prof. Yitzhak Katz, MD, FAAAAI1,2, 1Assaf Harofeh, Zerifin, Israel, 2Department of Pediatrics, Sackler School of Medicine, Tel Aviv, Israel, 3Assaf Harofeh, Israel Progression Towards Increasing Tolerance To Less Extensively Heat-Denatured Milk Products Hugh A. Sampson, MD, FAAAAI1, Dr. George N. Konstantinou, MD, PhD, MSc2,3, Jacob Daniel Kattan, MD4, Madhan Masilamani, PhD4, Mrs. Beth D. Strong, RN CCRC5, Mr. Tee Bahnson, BS, MPH6, Ms. Kaitie Fernandez7 and Dr. Anna H. Nowak-Wegrzyn, MD, FAAAAI4, 1Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 2424 General Military Training Hospital, Thessaloniki, Greece, 3First Pediatric Department, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece, 4Icahn School of Medicine at Mount Sinai, New York, NY, 5Icahn School of medicine at Mount Sinia, New York, NY, 6 Rho Federal Systems Division, Inc., Chapel Hill, NC, 7Rho Federal Systems Division, Inc., Chapel Hill, NC, Chapel Hill, NC Cow’s Milk Allergen Specific CD4+ T Cell Responses In Patients With Persistent Cow’s Milk Allergy Dr. Fatima S. Khan, MD, Altru, Grand Forks, ND, Nupur Bhatnagar, PhD, Benaroya Research Institute, Seattle, WA, Dr. David Robinson, Virginia Mason Medical Center and William W. Kwok, PhD, Benaroya Research Institute at Virginia Mason, Seattle, WA The Role Of Skin Prick Testing and Specific IgE To Boiled Versus Unheated Cow Milk In Cow Milk Allergic Children Dr. Anilkumar Katta, MD, Saint Louis University, Saint Louis, MO, Dr. Julie Hong, MD, St. Louis University, Portland, OR and Dr. Alan Knutsen, MD, FAAAAI, Saint Louis University School of Medicine, Saint Louis, MO Comparing The Utility Of Skin Prick Testing Using Commercial Extracts and Fresh Food In Diagnosing Peanut Allergy Dr. Carah Santos, MD, Dr. Matthew Strand, PhD, Pearlanne Zelarney, MS and David Mark Fleischer, MD, FAAAAI, National Jewish Health, Denver, CO Variability Of Major Allergens In Commercially Available Peanut Extracts For Skin Prick Testing Dr. Yong Luo, MD, PhD, Dr. Vincent R. Bonagura, MD, FAAAAI and Dr. David Rosenthal, DO, Division of Allergy/Immunology, Departments of Medicine and Pediatrics, Hofstra North Shore-LIJ School of Medicine, Great Neck, NY Ara h 2 and The Relative Risk Of Other Sensitizations Dr. James Thompson, Fellow-In-Training, ., Evans, GA, Dr. Daniel Duquette, PhD, UW La Crosse, La Crosse, WI and Dr. Brock Williams, PhD, U. of Missouri Medical School, Olathe, KS Variability Of Repeat Peanut Serum IgE Levels Tricia D. Lee, MD, Icahn School of Medicine at Mount Sinai, Jacob Daniel Kattan, MD, Icahn School of Medicine at Mount Sinai, New York, NY, Dr. Manish Ramesh, MD, PhD, Mount Sinai School of Medicine, New York, NY and Dr. Julie Wang, MD, FAAAAI, The Icahn School of Medicine at Mount Sinai, New York, NY Does Peanut Allergen Conjunctival Provocation Test Reflect Specific IgE Levels To Peanut? Helene Lindvik, MD1, Petter Mowinckel, M.Sc.2, Jesintha Navaratnam, MD3, Prof. Karin Cecilie Lødrup Carlsen, MD, PhD1,4, Prof. Magnus Borres, Md, Phd, FAAAAI5, Dr. Bente Kvenshagen, MD2 and Prof. Kai Hakon Carlsen, MD, PhD1,4, 1Department of Paediatrics, Oslo University Hospital, Oslo, Norway, 2Oslo University Hospital, Oslo, Norway, 3Department of Ophthalmology, Oslo University Hospital, Oslo, Norway, 4The Faculty of Medicine, University of Oslo, Oslo, Norway, 5Department of Womens and Childrens Health, Uppsala Univerisity, and Thermo Fisher Scientific, Uppsala, Sweden

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The Use Of The ISAC Mircroarray Platform In Food Allergic Patients Jacob Daniel Kattan, MD1, Gustavo Gimenez, BA1, Jay A. Lieberman, MD2 and Hugh A. Sampson, MD, FAAAAI3, 1Icahn School of Medicine at Mount Sinai, New York, NY, 2University of Tennessee, Memphis, TN, 3Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY IgE Antibodies To Ara h 2 and Ara h 6 By Immunocap ISAC Distinguish Peanut Anaphylaxis Children From Asymptomatic Peanut Sensitization Dr. Rumiko Shibata, MD, PhD1, Dr. Youko Murakami, MD1 and Dr. Hiroshi Odajima2, 1Department of Pediatrics, Fukuoka National Hospital, Fukuoka, Japan, 2Fukuoka National Hospital, Fukuoka, Japan Molecular Component Testing For Peanut Allergy Reactivity Differs Based On Age Dr. Michelle L. Altrich, PhD, Viracor-IBT Laboratories, Lee’s Summitt, MO CD-Sens and Component Resolved Diagnostics In Diagnosing Hazelnut Allergy Dr. Josef Brandstr€ om, MD1, Prof. Magnus Borres, Md, Phd, FAAAAI2, Prof. S. G. O. Johansson, MD, PhD, FAAAAI3, Ms. Agneta Jansson Roth1, Ms. Ann-Charlotte Sundqvist1, Dr. Gunnar Lilja, MD, PhD1, Dr. Anna Nopp, PhD3 and Dr. Caroline Nilsson, MD, PhD1, 1Department of Clinical Science and Education, S€ odersjukhuset, Karolinska Institutet and Sachs Childrens Hospital, S€ odersjukhuset, Stockholm, Sweden, 2Department of Womens and Childrens Health, Uppsala Univerisity, and Thermo Fisher Scientific, Uppsala, Sweden, 3Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institutet, Stockholm, Sweden Effect Of Oleic Acid On The Allergenic Properties Of Peanut and Cashew Allergens Si-Yin Chung, PhD1, Christopher P. Mattison, PhD1, Shawndrika Reed1, Dr. Richard L. Wasserman, MD, PhD, FAAAAI2 and Wendy A. Desormeaux1, 1USDA-ARS-SRRC, New Orleans, LA, 2Allergy/ Immunology Research Center of North Texas, Dallas, TX Identification Of Conformational IgE Epitopes Of Ara h 2 and Ara h 6 Dr. Xueni Chen, University of Colorado, Aurora, CO and Dr. Stephen C. Dreskin, MD, PhD, FAAAAI, University of Colorado Denver, Aurora, CO Basophil Response To Storage Proteins and Oleosins From Sunflower Seed Maria Luisa Macias1, Dr. Francisca Gomez, MD, PhD2, Araceli Diaz3, Dr. Cristobalina Mayorga, PhD1, Dr. Ana Aranda, PhD1, Miguel Gonzalez1, Dr. Natalia Blanca-Lopez, MD, PhD4, Dr. Gabriela Canto, MD, PhD4, Ms. Miriam Osorio1, Dr. Maria Garrido, PhD3, Dr. Maria J Torres, MD, PhD2 and Dr. Miguel Blanca, MD, PhD2, 1Research Laboratory, Carlos Haya Hospital-FIMABIS, Malaga, Spain, 2Allergy Service, Carlos Haya Hospital, Malaga, Spain, 3Plant Biotechnology Institute (UPM-INIA), Madrid, Spain, 4 Allergy Service, Infanta Leonor Hospital, Madrid, Spain Utility Of Ovomucoid Specific IgE In Predicting Unheated Egg Food Challenge Outcomes Dr. Katherine S. Larabee, MD1, Dr. William J. Sheehan, MD2,3, Dr. Lisa M. Bartnikas, MD2,3, Mr. Carter Petty, MA3, Dr. Lynda C. Schneider, MD, FAAAAI2,3 and Dr. Wanda Phipatanakul, MD, MS, FAAAAI2,3, 1Massachusetts General Hospital for Children, Boston, MA, 2Harvard Medical School, Boston, MA, 3Boston Children’s Hospital, Boston, MA Allergy Testing In Childhood: Agreement Between Skin Prick Test and Specific IgE In Preschool Children Ann-Marie M. Schoos, MD, Bo Chawes, MD, Nilofar Følsgaard, MD, Nasim Samandari, MD, Klaus Bønnelykke, MD and Dr. Hans Bisgaard, MD DMSci, Danish Pediatric Asthma Center, Gentofte, Denmark

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Measurement Of Allergenic Components For Predicting Clinically Relevant Shrimp Allergy In House Dust Mite Sensitized Children Prof. Man-Yong Han, MD, PhD, Department of Pediatrics, CHA University School of Medicine, Seongnam, South Korea, Prof. Heysung Baek, MD, PhD, Department of Pediatrics, Hallym University College of Medicine, Seoul, South Korea and Prof. Ha-Baik Lee, MD, PhD, Department of Pediatrics, Hanyang University School of Medicine, Seoul, South Korea Cross Reactivity Of Alpha Gal Allergy With An Extended Red Meat Panel Dr. Linda Flebbe-Rehwaldt, PhD, Viracor-IBT Laboratories, Lee’s Summit, MO and Dr. Michelle L. Altrich, PhD, ViracorIBT Laboratories, Lee’s Summitt, MO Prediction Of Tolerance To Food Allergens By The AllergenSpecific IgE/Total IgE Ratio Ms. Claudia Lau1, Dr. Ruchi Gupta, MD, MPH1,2, Dr. Aaron Donnell, MD3, Prof. Robert G. Hamilton, PhD D.ABMLI FAAAAI4 and Dr. Kelly Newhall, MD3, 1Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 2Northwestern University Feinberg School of Medicine, Chicago, IL, 3Chicago Family Asthma & Allergy, Chicago, IL, 4Johns Hopkins University School of Medicine, Baltimore, MD T Regulatory Cells and Food Specific Responses In Peanut and Egg Allergic Children Nashmia Qamar, DO, Anna B. Fishbein, Kristin A. Erickson, Miao Cai, MS, Christine Szychlinski, MS, APN, CPNP, Ramsay L. Fuleihan, MD and Dr. Anne Marie Singh, MD, Division of Allergy & Immunology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL Surveillance Of Persistent Nut Allergy Including The Use Of Basophil Activation Test In Pediatric Patients Dr. Ashleigh A. Olson, MD1, Kristin A. Erickson2, Miao Cai, MS2, Ms. Christine Szychlinski, APN, CPNP3 and Dr. Anne Marie Singh, MD2, 1Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 2Division of Allergy & Immunology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 3Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL Assessment Of a Modified Basophil Activation Test In The Diagnosis Of Peanut Allergy Dr. Monika Saeedian, MD, University of California, Los Angeles and Dr. Maria Garcia-Lloret, MD, UCLA Utility Of Probability Curves Using 3gAllergy For Diagnosis Of Wheat Allergy Sakura Sato1, Kiyotake Ogura1, Yasunori Sato2 and Motohiro Ebisawa, MD, PhD, FAAAAI1, 1Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan, 2Department of Biostatistics, Clinical Research Center Chiba University Skin Prick Test and Specific IgE To Purified Peanut Allergens Are Related To The Age Of Onset Of Sympstons Dr. Maria Salas, MD, PhD1, Dr. Francisca Gomez, MD, PhD2, Dr. Ana Aranda, PhD3, Dr. Carmen Rondon, MD, PhD1, Dr. Natalia Blanca-L! opez, MD, PhD4, Dr. Gabriela Canto, MD, PhD4, Dr. Maria J Torres, MD, PhD1, Dr. Cristobalina Mayorga, PhD3, Dr. Miguel Blanca, MD, PhD1 and Maria Isabel S!anchez Rivas5, 1 Allergy Service, Carlos Haya Hospital, M!alaga, Spain, 2Allergy Service, Carlos Haya Hospital, Spain, 3Research Laboratory, Carlos Haya Hospital-FIMABIS, M!alaga, Spain, 4Allergy Service, Infanta Leonor Hospital, Madrid, Spain, 5Allergy Service Carlos Haya Hospital, Malaga, Spain

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The Relationship Between Mitochondrial Haplogroups Variant on Children with Cow Milk Allergy Expressed As Atopic Dermatitis and Gastrointestinal Disease Dr. Juan Carlos Muino, MD, PhD, FAAAAI1, Dr. Raul Boudet1, Dr. Maria Chaig1, Dr. Roberto Chaig1, Prof. Nelida Gerez2 and Prof. Juan Carlos Copioli1, 1FAC CS MED UNC, Cordoba, Argenordoba, Argentina tina, 2FAC CS MED UNC, C! Detection Of Peanut Allergens In Breast Milk and Saliva Dr. Kelli M. Rose, MD1, Christian Plaisance2, Casey C. Grimm, PhD2, Hsiaopo Cheng, M.S.2, Tysheena Charles, MS2, Saeed A. Jortani3 and Soheila J. Maleki, PhD2, 1Tulane University, New Orleans, LA, 2USDA-ARS-SRRC, New Orleans, LA, 3University of Louisville, Louisville, KY Importance Of High Molecular Weight Proteins In Walnut Allergy Melanie L. Downs, M.S.1,2, Dr. Aida Semic-Jusufagic, MD2, Dr. Angela Simpson, MD2, Prof. Adnan Custovic, MD, PhD, FAAAAI2, Dr. Savas Savatianos, MD3, Dr. Nikolaos G. Papadopoulos, MD, FAAAAI3, Dr. Joan Bartra, MD, PhD4, Dr. Montserrat Fernandez-Rivas5, Joe L. Baumert1, Steve L. Taylor, PhD1 and Prof. E.N. Clare Mills, BSc PhD2, 1Food Allergy Research and Resource Program, University of Nebraska-Lincoln, Lincoln, NE, 2Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, 3Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece, 4Allergy Unit, Service of Pneumology and Respiratory Allergy, Hospital Clinic (ICT), Barcelona, Spain, 5Allergy Department, Hospital Clinico San Carlos, IdISSC, Madrid, Spain Characterizing The Effect Of Sodium Sulfite On Cashew Allergens Christopher P. Mattison, PhD1, Wendy A. Desormeaux1, Dr. Richard L. Wasserman, MD, PhD, FAAAAI2 and Casey C. Grimm, PhD1, 1USDA-ARS-SRRC, New Orleans, LA, 2Allergy/Immunology Research Center of North Texas, Dallas, TX Cross-Sensitization To Rosaceae Fruits and Their Molecular Components In Japanese School Children Dr. Junya Hirayama1, Dr. Atsushi Yamashita1, Dr. Mizuho Nagao, MD1, Dr. Reiko Tokuda1,2, Dr. Keigo Kainuma, MD1 and Dr. Takao Fujisawa, MD, FAAAAI1, 1Institute for Clinical Research, Mie National Hospital, 2Tokuda Family Clinic Food-Specific IgE Panel Testing Commonly Results In Misdiagnosis and Inappropriate Dietary Exclusion Dr. Maryam Saifi, MD, University of Texas Southwestern Medical Center, Dallas, Mrs. Maria G. Crain, CPNP AE-C, Children’s Medical Center Dallas, Dallas, TX, Dr. Pooja Varshney, MD, Dell Children’s Medical Center, ’Specially for Children, Austin, TX and Dr. J. Andrew Bird, MD, FAAAAI, UT Southwestern Medical Center, Dallas, TX Epitope Mapping The Peanut Panallergen Ara h 8 Barry K. Hurlburt, PhD1, Hsiaopo Cheng, M.S.1, Dr. Lesa Offermann2, Dr. Maksymilian Chruszcz, PhD3, Dr. Alexandra F. Santos, MD, MSc4, Prof. Gideon Lack, MD FRCPCH5 and Soheila J. Maleki, PhD1, 1USDA-ARS-SRRC, New Orleans, LA, 2university of south carolina, columbia, SC, 3University of South Carolina, Columbia, SC, 4King’s College London, London, United Kingdom, 5 St Thomas’ Hospital, St Thomas’ Hospital, London, United Kingdom Simulated Roasting Affects Patient IgE Binding To Ara h 2 Tysheena Charles, MS1,2, Casey C. Grimm, PhD2, Jane McBride2, Samuel Landry, PhD1 and Soheila J. Maleki, PhD2, 1Tulane University Health Sciences Center, New Orleans, LA, 2USDA-ARSSRRC, New Orleans, LA Transfer Of Peanut IgE Sensitization Following Kidney and Pancreas Transplant Alalia Berry, M.D., University of Utah, Department of Medicine, Salt Lake City, UT, Dr. Rafael Firszt, MD, MBA, Pediatrics, University of Utah, Salt Lake City, UT, Dr. Fuad Shihab, MD,

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Abstracts AB319

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

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University of Utah,Division of Nephrology, Salt Lake City, UT, Dr. Jeffrey Campsen, M.D. FACS, University of Utah, Division of Transplant Surgery, Salt Lake City, UT and Craig Myrick, R.N., Intermountain Donor Services, Salt Lake City, UT

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Urticaria 3208 Sunday, March 2nd, 2014, 9:45 AM - 10:45 AM 409

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Outcome Measures Of Challenge Testing In Patients With Physically Induced-Urticaria Dr. Dean D. Metcalfe, MD1, Sarah Arceo, RN1, Michael L. Young, RN MPH2, Celeste Nelson, NP1 and Dr. Hirsh D. Komarow, MD3, 1 NIH/NIAID/Laboratory of Allergic Diseases, Bethesda, MD, 2 2Clinical Research Directorate/CMRP, SAIC-Frederick Inc, Frederick National Laboratory for Clinic Research, Frederick, MD, 3 Laboratory of Allergic Diseases, NIAID/NIH, Bethesda, MD Whole Blood Histamine Concentration Response To Omalizumab In Patients With Chronic Idiopathic/Spontaneous Urticaria: Post Hoc Analysis Of Asteria I, Asteria II and Glacial Studies Dr. Sarbjit S. Saini, MD, FAAAAI1, Dr. Karin Rosen, MD, PhD2, Dr. Hsin-Ju Hsieh, PhD2, Ms. Patricia M. Sterba, MS1, Mr. JohnPaul Courneya, MS1, Dr. Henry Hulter2 and Dr. Hubert Chen2, 1 Johns Hopkins University, Baltimore, MD, 2Genentech, Inc., South San Francisco, CA Efficacy Of Omalizumab In Patients With Chronic Idiopathic/ Spontaneous Urticaria With Different Background Therapy: Post Hoc Analysis Of Asteria I, Asteria II, and Glacial Studies Dr. Jonathan A. Bernstein, MD, FAAAAI1, Dr. Sarbjit S. Saini, MD, FAAAAI2, Prof. Marcus Maurer, MD3, Dr. Hsin-Ju Hsieh, PhD4, Dr. Hubert Chen4, Dr. Janice Canvin, MD, FRCPC5, Dr. Thomas B. Casale, MD, FAAAAI6, Dr. Allen P. Kaplan, MD, FAAAAI7 and Dr. Karin Rosen, MD, PhD4, 1Division of Immunology Allergy & Rheumatology, University of Cincinnati Medical Center, Cincinnati, OH, 2Johns Hopkins University, Baltimore, MD, 3Department of Dermatology and Allergy, Charite – Universit€atsmedizin, Berlin, Germany, 4Genentech, Inc., South San Francisco, CA, 5Novartis Pharmaceuticals UK Limited, Horsham, West Sussex, United Kingdom, 6Univeristy Of South Florida Morsani College Of Medicine, Tampa, FL, 7Medical University of South Carolina, Charleston, SC Angioedema and Angioedema Management From Asteria I and Asteria II: Phase III Studies To Evaluate The Efficacy and Safety Of Omalizumab In Patients With Chronic Idiopathic/ Spontaneous Urticaria Who Remain Symptomatic Despite H1 Antihistamine Treatment Dr. James Zazzali, PhD, Dr. Karin Rosen, MD, PhD, Mary S. Bradley, MS and Karina Raimundo, BPharm, MS, Genentech, Inc., South San Francisco, CA Improvements In Health-Related Quality Of Life From Asteria I & II: Phase III Studies To Evaluate The Efficacy and Safety Of Omalizumab In Patients With Chronic Idiopathic/Spontaneous Urticaria Who Remain Symptomatic Despite H1 Antihistamine Treatment Karina Raimundo, BPharm, MS, Dr. James Zazzali, PhD, Benjamin Trzaskoma and Dr. Karin Rosen, MD, PhD, Genentech, Inc., South San Francisco, CA Estimating The Minimal Important Difference (MID) Of The Measures In The Urticaria Patient Daily Diary (UPDD): Updated Findings Using Data From The Asteria I, Asteria II, and Glacial Studies Of Omalizumab In Chronic Idiopathic/ Spontaneous Urticaria Susan Mathias1, Dr. Ross D. Crosby2, Dr. Karin Rosen, MD, PhD3 and Dr. James Zazzali, PhD3, 1Health Outcomes Solutions,

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2 Neuropsychiatric Research Institute, Fargo, 3Genentech, Inc., South San Francisco, CA Treatment With Off-Label Omalizumab In Chronic Idiopathic Histaminergic Urticaria - Angioedema Resistant To Conventional Treatment Dr. Y. V. Rijo, MD1, Dr. P. Palao, MD1, Dr. N. Prior, MD2, Dr. A. Fiandor, MD1, Dr. M.C. Lopez-serrano, MD, PhD1, Dr. S. Olalde, MD1, Mrs. M.C. Torres1, Dr. S. Quirce, MD, PhD1 and Dr. T. Caballero, MD, PhD1, 1Hospital La Paz Institute for Health Research (IdiPaz), Allergy department., Madrid, Spain, 2Hospital Severo Ochoa, Madrid, Spain Real-Life Experiences With Omalizumab For The Treatment Of Severe Refractory Chronic Urticaria (SRCIU) Carly Barron1, Dr. Gordon L. Sussman, FAAAAI1,2, Dr. Jacques Hebert, MD3,4, Jiayi Bian1, Rose-Marie Caron-Guay4, Stephanie Laflamme4 and Simon Stern1, 1Gordon Sussman Clinical Research Inc., Toronto, ON, Canada, 2University of Toronto, Faculty of Medicine, Toronto, ON, Canada, 3University Laval Center Hospital, Quebec City, QC, Canada, 4Centre de Recherche Appliquee en Allergie de Quebec, Quebec City, QC, Canada Outcomes Of Chronic Urticaria Patients Treated With Hydroxychloroquine Dr. Jacqueline Eastman, Dr. Nicole Wilde and Dr. Maya R. Jerath, MD, PhD, University of North Carolina, Chapel Hill, NC Polymorphisms Of Genes Encoding Interleukin-4 and Its Receptor Are Associated With Chronic Idiopathic Urticaria Ms. Zahra Aryan1,2, Dr. Marzieh Tavakol3,4, Prof. Ali Akbar Amirzargar, PhD1, Prof. Masoud Movahedi3, Dr. Alireza Zare bidoki3, Dr. Mohammad Gharagozlou, MD3, Prof. Asghar Aghamohammadi5, Dr. Mohammad Nabavi6, Mr. Alireza Ahmadvand3, Dr. Nasrin Behniafard, MD3, Ms. Kimia Heidari3, Ms. Samaneh Soltani3 and Dr. Nima Rezaei, MD, PhD1, 1Molecular Immunology Research Center; and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, 2National elites foundation, Iran., 3Molecular Immunology Research Center; and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, Iran, 4Student Scientific Research Center (SSRC), School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, 5Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran, 6Department of Allergy and Immunology, Rasool-e-Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran, Iran Chronic Idiopathic Urticaria Index (CIUI) As a Tool For Predicting Response To Cyclosporine In Pediatric Patients With Refractory Autoimmune Urticaria Dr. Moira E. Breslin, MD, MSc, Pediatrics, UCLA Medical Center, Los Angeles, CA, Dr. Bob Geng, MD, UCLA, Los Angeles, CA and Dr. Robert Roberts, MD, PhD, UCLA Cholinergic Urticaria: Case Report Of Urticaria Induced By Acquired Seasonal Hypohidrosis Dr. Yuriy Zgherea, MD, Dr. Muhammad Imran, MD, Dr. Jaron T. Abbott, MD, Dr. Aaron K. Pinion, DO, Dr. Selina Gierer, DO and Dr. John D. Martinez, MD, University of Kansas Medical Center Relation Between Environmental Allergen Exposure and Chronic Urticaria Dr. Denisa Ferastraoaru, MD, MSc, Allergy - Immunology, Albert Einstein College of Medicine / Montefiore Medical Center, Bronx, NY, Dr. Sunit Jariwala, MD, Albert Einstein/Montefiore Medical Center, New York, NY, Dr. Golda Hudes, MD, PhD, Albert Einstein/ Montefiore Medical Center, New York, NY and Dr. David L. Rosenstreich, MD, FAAAAI, Albert Einstein/Montefiore Medical Center, Bronx, NY Relationship Of Clinical Characteristics Of Chronic Urticaria In Children To Treatment Outcome Lisa Neverman, B.S. and Prof. Miles M. Weinberger, MD, FAAAAI, University of Iowa, Iowa City, IA

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Clinical Characteristics Of Elderly Chronic Urticaria Dr. Ga Young Ban, MD1, Ji Hye Kim, MD2, Mi-Yea Kim, MD1, Dr. Hye-Soo Yoo, MD1, Dong-Ho Nahm, MD, PhD1, Dr. Young Min Min Ye, MD1, Yoo Seob Shin, MD, PhD1 and Prof. HaeSim Park, MD, PhD1, 1Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea, 2 Department of Internal medicine, Konyang University College of Medicine, Daejeon, South Korea Decreased Serum Vitamin D Level In Patients With Chronic Spontaneous Urticaria Dr. Tadech Boonpiyathad, MD, Dr. Panitan Pradappongsa and Dr. Atik Sangasapaviriya, Phramonkutklao Hospital, Bangkok, Thailand Supplementation With Vitamin D In a Cohort Of Patients With Chronic Urticaria Results In Clinical Improvement Dr. Anastasiya Kleva, MD, Dr. Sherry Farzan, MD and Dr. Blanka M. Kaplan, MD, FAAAAI, Department of Pediatrics, Division of Allergy & Immunology, Hofstra-North Shore-LIJ School of Medicine, Great Neck, NY Clinical and Laboratory Features Of Chronic Urticaria Dr. Koji Masuda, Kyoto Prefectural University of Medicine, Kyoto, Japan Serum Specific IgE Response To Thyroid Autoantigens In Aspirin Intolerant Urticaria Patients Dr. Yoo Seob Seob Shin, MD, PhD, Dr. Hye-Soo Yoo, MD, Dr. Ga Young Ban, MD, Dr. Young Min Min Ye, MD and Prof. HaeSim Park, MD, PhD, Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea Basophil Receptor Profiles In Chronic Idiopathic Urticaria Dr. Eric Oliver, MD, Ms. Patricia M. Sterba, MS and Dr. Sarbjit S. Saini, MD, FAAAAI, Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD Altered Systemic Adipokine Levels In Patients With Chronic Idiopathic Urticaria Dr. Young Min Ye, MD, Dr. Ga Young Ban, MD, Eun-Mi Yang, Dr. Hye-Soo Yoo, MD, Yoo Seob Shin, MD, PhD and Prof. HaeSim Park, MD, PhD, Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea Predicting Clinical Responsiveness To Dapsone In The Treatment Of Chronic Idiopathic Urticaria (CIU) Dr. Ryan A. Steele, DO, MS1, Dr. Janelle Sher, MD2, Dr. Mark Davis-Lorton, MD, FAAAAI2, Dr. Marcella R. Aquino, MD, FAAAAI2 and Dr. Luz S. Fonacier, MD, FAAAAI3, 1Allergy & Immunology, Winthrop University Hospital, Mineola, NY, 2Winthrop University Hospital, Allergy & Immunology, Mineola, NY, 3Section of Allergy and Clinical Immunology, Department of Medicine, Winthrop University Hospital, Mineola, NY Chronic Urticaria/Angioedema and Auto-Immunity: Diagnostic Profile Among Patients Attending a Reference Clinic In Brazil Dr. Daniel L. Cordeiro, MD1, Dr. Janaina Fernandes de Melo Sousa, MD1, Dr. Karine Boufleur, MD1, Dr. Priscila Botelho Palhas, MD1, Dr. Tha!ıs Mendonc¸a, MD1, Dr. Janaina Michele de Lima Melo, MD1 and Dr. Luisa Karla P. Arruda, MD, PhD, FAAAAI2, 1 Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil, 2School of Medicine of Ribeirao Preto, Ribeirao Preto, Brazil Chronic Spontaneous Urticaria-The Saskatchewan Experience and Questionnaire Survey Ms. Natasha Gattey, University of Saskatchewan, Saskatoon, SK, Canada A Case Of Incontinentia Pigmenti Masquerading As Urticaria Pigmentosa Dr. Erin C. Donahue, MD and Dr. Sonal R. Patel, MD, White Memorial Medical Center, Los Angeles, CA

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Acute Urticaria Caused By Infection In 72 Chinese Patients Prof. Ting Xiao, The First Affiliated Hospital, China Medical University, Shenyang, China and Dr. Lin Zhu, The First Affiliated Hospital, China Medical University Assessment Of Acute Urticaria In Pediatric Emergency Department Dr. Raquel Reis Pitchon, Clinical Research1, Mr. Daniel Reis, Medical Student2, Ms. Adriana Reis, Medical Student3, Mr. Andr!e Chuster, Medical Student3, Prof. Teresa Mohallen, Professor2, Dr. Jos!e Ribeiro, Pediatrician4, Dr. N!ıvea Claret, Pediatrician4, Dr. Giane Chaves, Pediatrician4, Dr. Virgilio Aleixo, Pediatrician4, Dr. Maria do Socorro Fernandes, Pediatrician4 and Dr. Fausto Pacheco, Pediatrician4, 1Mater Dei Hospital, BELO HORIZONTE, Brazil, 2Universidade Federal de Minas Gerais, BELO HORIZONTE, Brazil, 3Faculdade de Ciencias M!edicas, BELO HORIZONTE, Brazil, 4Hospital Mater Dei, BELO HORIZONTE, Brazil OTC Pills and Severe Urticaria Ivan Cherrez1, Enrique Loayza2, Leonardo Greiding3, Jose M. Vilema4, Juan Calderon4, Erick Calero4 and Gabriela Martinetti4, 1 Respiralab - Hospital Kennedy, Guayaquil, Ecuador, 2Respiralab - Hospital Luis Vernaza, Guayaquil, Ecuador, 3Instituto Argentino de Alergia e Inmunologia, Buenos Aires, Argentina, 4Respiralab, Guayaquil, Ecuador Hypocomplementemic Urticarial Vasculitis With Elevated Immune Complexes and Nasal Polyposis Dr. Khrystyna Lishchuk-Yakymovych, MD, Medical University, Lviv, Ukraine, Dr. Roman Pukalyak, Danylo Halytskyy Lviv National Medical University, Ukraine and Prof. Lawrence M. DuBuske, MD, FAAAAI, George Washington University School of Medicine, DC

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Abstracts AB321

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

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Nannies Knowledge, Attitude and Management Of Food Allergies In Children; An Online Survey Dr. Justin C. Greiwe, MD1, Dr. Lisanne P. Newton, MD2, Dr. Fouseena Pazheri, MD3 and Dr. Brian C. Schroer, MD2, 1Cleveland Clinic, Cleveland, OH, 2Cleveland Clinic Foundation, Cleveland, OH, 3Cleveland Clinic Does Omega-3 Fatty Acid Supplementation During Pregnancy Prevent Childhood Atopic Disease? Dr. Manika Girdhar, DO, Children’s Mercy Hospital & Clinics, Kansas City, MO and Dr. Christina E. Ciaccio, MD, FAAAAI, Children’s Mercy Hospital, Kansas City, MO Helping Children Cope With Discomfort Associated With Skin Prick Testing In a Pediatric Setting: A Quality Improvement Report Ms. Amanda Troger, BSN, RN1, Ms. Humaira Robinson, BSN RN1, Ms. Sonia C. Mancia, RN2, Dr. Hemant P. Sharma, MD MHS FAAAAI3 and Dr. Katherine Kelly, PhD, RN1, 1Children’s National Medical Center, Washington, DC, 2Children’s National Medical Center, Fairfax, VA, 3Children’s National Medical Center Are Total Serum IgE Levels Good Predictors Of Allergies In Children? Dr. Stephanie Barnes-Mercado1, Dr. Vylma Velazquez, MD2 and Dr. Annette Pietri-Ramirez1, 1Hospital Episcopal San Lucas-Ponce, 2 Hospital Episcopal San Lucas, Ponce, PR Relationship Between Maternal Fat During Pregnancy and Risks Of Allergic and Respiratory Diseases In Early Childhood: The Mothers and Children’s Environmental Health Study Prof. Ja Hyeong Kim, MD1, Prof. Eun-Hee Ha, MD2, Prof. Hye sook Park, MD2, Prof. Mina Ha, MD3, Prof. Yun-Chul Hong,

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MD4, Prof. Yangho Kim, MD5, Mr. Min-ho Kim, PhD6, Prof. Jin-A Jung, MD7 and Prof. NamSoo Chang, PhD8, 1Ulsan University Hospital, Ulsan, South Korea, 2Department of Preventive Medicine, School of Medicine, Ewha Womans University, South Korea, 3Department of Preventive Medicine, Dankook University College of Medicine, 4Department of Preventive Medicine, Seoul National University College of Medicine, South Korea, 5Department of Occupational and Environmental Medicine, University of Ulsan, Collage of Medicine, Ulsan University Hospital, South Korea, 6Ulsan University Hospital, South Korea, 7Dong-A University College of Medicine, Busan, 8Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Korea, South Korea The Efficacy Of Training School and Nursery Personnel On Epinephrine Autoinjector Use Dr. Mari Sasaki, MD, Dr. Mayumi Furukawa, MD, Dr. Koichi Yoshida, MD and Dr. Akira Akasawa, MD, PhD, Division of Allergy, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan Referral Patterns To An Outpatient Allergy/Immunology Clinic At a Tertiary Care Pediatric Academic Center Kasey Strothman, MD1,2, David R. Stukus, MD, FAAAAI1 and Rebecca Scherzer, MD, FAAAAI1, 1Nationwide Children’s Hospital, Columbus, OH, 2Wexner Medical Center at The Ohio State University, Columbus, OH Food Allergy Education Significantly Improves School Personnel Food Allergy Knowledge and Bullying Attitudes Niti Y. Chokshi, MD1, Kristin H. Dillard, MD1, Danielle Guffey, MS2, Charles Minard, PhD2 and Carla M. Davis, MD1, 1Baylor College of Medicine and Texas Children’s Hospital, Section of Immunology, Allergy and Rheumatology, Houston, TX, 2Baylor College of Medicine, Houston, TX

Health Information Technology

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Chronic Rhinosinusitis and Polyps 3211 Sunday, March 2nd, 2014, 9:45 AM - 10:45 AM 452

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How Patients Rate Their Allergists Online: Analysis Of Physician-Review Websites Xiao C. Wan, M.D., University of Chicago, Department of Internal Medicine, Chicago, IL and Ves Dimov, MD, Section of Allergy, Asthma and Immunology, Department of Pediatrics, Department of Medicine, University of Chicago, Chicago, IL Improving Allergy and Immunology Education For The Internal Medicine Resident Through Internet-Based Learning Modules Dr. Michelle C. Fox, MD1,2, Dr. Paige G. Wickner, MD3 and Dr. Mariana C. Castells, MD, PhD, FAAAAI4, 1Brigham and Women’s Hospital, 2Harvard Medical School, 3Brigham & Women’s Hospital, Chestnut Hill, MA, 4Division of Rheumatology, Allergy and Immunology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA Electronic Patient Data Acquisition Tablet (ePDAT) Provides Customized, Flexible Scheduling For Collecting Patient Reported Outcomes (ePRO) With High Usability and Compliance Ideal For Use In Single and Multicenter Environmental Exposure Chamber Studies Mr. Dan Wilson, Dr. Piyush Patel, MD, FRCP, Konrad Boczula and Dr. AnneMarie Salapatek, PhD, Inflamax Research, Mississauga, ON, Canada Feasibility and Acceptability Of a Novel Asthma Self-Management Smartphone Application For Children and Adolescents Nabeel Farooqui, MD1,2, Gary Phillips, M.A.S.2 and David R. Stukus, MD, FAAAAI1,2, 1Nationwide Children’s Hospital, Columbus, OH, 2Wexner Medical Center at The Ohio State University, Columbus, OH

Experience In The Development Of a Mobile Diagnosis Support System For Asthma: Intelimed Prof. Silvia Wanick Sarinho Sr., Prof.Dr.1, Prof. Julio Ven^ancio Menezes Junior1, Prof. Cristine Gusm~ao1 and Nilza R S Lyra, MD2, 1Universidade Federal de Pernambuco, 2Universidade Federal de Pernambuco, Recife PE, Brazil An Assessment Of Food Allergy Knowledge Among Parents Of Children With Food Allergy and The Role Of An Educational Website Jamee Castillo, MD1, Neha Mehrotra, MD1, Raoul L. Wolf, MD, FAAAAI2 and Ves Dimov, MD3, 1Internal Medicine Residency Program, Department of Medicine, University of Chicago, Chicago, IL, 2 Section of Allergy, Asthma and Immunology, Department of Pediatrics, Department of Medicine, University of Chicago, Chicago, IL, 3University of Chicago Medicine, Chicago, IL

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The Differences Of TNF-a, Rantes, Interleukin-5 Levels In Nasal Polyps With Allergic, Local Allergic, and Non-Allergic Rhinitis Prof. Jae-Won Oh, MD, PhD, FAAAAI, Hanyang University Guri Hospital, Seoul, Dr. Joo-Hwa Kim, MD, Hanyang University Guri Hospital, Seoul, South Korea and Dr. JIn-Hyuk Cheong, Hanygang University Guri Hospital, Guri, South Korea Cigarette Smoke Promotes Eosinophilic Inflammation, Airway Remodeling and Nasal Polyps In a Murine Polyp Model Dr. Ji-Hun Mo, Department of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, South Korea and Ki-Il Lee, Dankook university, South Korea Evaluation Of Oral Antibiotics Versus Placebo For The Treatment Of Rhinosinusitits With Neutrophilia On Nasal Cytology Manar Abdalgani, MD1, Dr. Joud Hajjar, MD2, Krista Edelman, MD1 and Dr. Lawrence B. Schwartz, MD, PhD, FAAAAI1, 1Virginia Commonwealth University, Richmond, VA, 2Baylor Colleage of Medicine, Houston, TX Pediatric Allergic Fungal Otomastoiditis Improved With AntiIgE Therapy Dr. Diana K. Bayer, DO1, Dr. Ankhi Dutta, MD, MPH2,3, Dr. Robert Williamson, MD4, Dr. Andrew deJong, MD3,5, Dr. Keith Paull, MD3,6, Dr. I. Celine Hanson, MD, FAAAAI1 and Dr. Lisa R. Forbes, MD1, 1Baylor College of Medicine-Texas Children’s Hospital, Section of Immunology, Allergy, and Rheumatology, Houston, TX, 2 Health Point ABC Clinic, College Station, TX, 3Texas A&M Health Science Center, Bryan, TX, 4Texas Children’s Hospital-Baylor College of Medicine, Department of Surgery, Otolaryngology, Houston, TX, 5Texas ENT and Allergy, Bryan, TX, 6The Paull Allergy and Asthma Clinic, Bryan, TX Measurement Of Nasal and Exhaled Nitric Oxide In Chronic Rhinosinusitis and Its Comparison According To The Presence Of Nasal Polyps Dr. Woo Yong Bae, MD, Department of Otorhinolaryngology, College of Medicine, Dong-A University, Busan, South Korea, Prof. Jin-A Jung, MD, Dong-A University College of Medicine, Busan and Dr. Young-Hee Nam, MD, Department of Internal Medicine, College of Medicine, Dong-A University, Busan, South Korea Post-Translational Modification By Serine Proteases Controls The CCL23 Activity In Nasal Polyps Of Chronic Rhinosinusitis Dr. Atsushi Kato, PhD1, Dr. Anjeni Keswani, MD1, Dr. Julie Kim, M.D.1, Ms. Julie Poposki, MS1, Dr. Sarah Peterson, MD1, Ms. Lydia Suh, BSc1, Mr. James Norton, MS1, Dr. Anju T. Peters, MD, FAAAAI1, Dr. Kathryn E. Hulse, PhD2, Dr. Leslie C. Grammer,

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MD, FAAAAI1, Dr. Bruce K. Tan, MD3, Dr. Rakesh Chandra, MD2, Dr. David Conley, MD3, Dr. Juan Jaen, PhD4, Dr. Thomas Schall, PhD4, Dr. Robert C. Kern, MD1,3 and Dr. Robert P. Schleimer, PhD FAAAAI5, 1Department of Medicine, Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Northwestern University, Chicago, IL, 3 Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, 4Chemocentryx Inc, Mountain View, CA, 5Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL Sinusitis In Latino Children Is Associated With Allergic Respiratory Diseases and Inversely Related To Native American Ancestry (GALA II Study) Dr. Jennifer A. Regan, MD, PhD1, Dr. Joy Hsu, MD, MSCI2, Ms. Elizabeth Nguyen, BS3, Ms. Lindsey Roth, MA4, Dr. Joshua Galanter, MD4, Dr. Sam Oh, PhD, MPH4, Ms. Celeste Eng, BS4, Mr. Fred Lurmann, MS5, Dr. Rajesh Kumar, MD, MS, FAAAAI6, Dr. Harold J. Farber, MD, MSPH7, Dr. Denise Serebrisky, MD8, Dr. Luisa Borrell, DDS, PhD9, Dr. Saunak Sen, PhD10, Dr. William Rodriguez-Cintron, MD11, Dr. Jose Rodriguez-Santana, MD12, Dr. Esteban Gonza Burchard, MD, MPH4 and Prof. Pedro C. Avila, MD, FAAAAI1, 1Feinberg School of Medicine, Northwestern University, Chicago, IL, 2Department of Medicine, Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Department of Medicine, University of California, San Francisco, California, San Francisco, CA, 4Department of Medicine, University of California, San Francisco, San Francisco, CA, 5Sonoma Technology, Inc., Petaluma, CA, 6Pediatric allergy, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 7Baylor College of Medicine and Texas Children’s Hospital, Houston, TX, 8Pediatric Pulmonary Division, Jacobi Medical Center, Bronx, NY, 9Department of Health Sciences, Graduate Program in Public Health, Lehman College, City University of New York, Bronx, NY, 10Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 11Veterans Caribbean Health Care System, San Juan, PR, 12Centro de Neumologia Pediatrica, San Juan, PR Evaluation Of Olfactory Function In Patients With Chronic Rhinitis Dr. Idalia V. Yanez-Perez, MD, Dr. Sandra N. Gonzalez-Diaz, MD, PhD, FAAAAI, Dr. Alejandra Macias-Weinmann, Dr. Alfredo Arias-Cruz, Dr. Lorena Rangel-Garza, Dr. Hilda Hernandez-Sanchez, MD, Dr. Rafael Perez-Vanzzini and Dr. Karla Mejia-Salas, Regional Center of Allergy and Clinical Immunology. University Hospital ‘‘Dr. Jose Eleuterio Gonzalez’’., Monterrey, Mexico A Method For Assessing Regional Determinants Of Eosinophilia In Chronic Rhinosinusitis Dr. Bruce K. Tan, MD1, Ms. Erin Rocci, BS2, Dr. Kent Lam, MD1, Ms. He Huang, MS1, Ms. Lydia Suh, BSc3, Mr. Avesh Thuluvath, BA4, Ms. Alcina K. Lidder, BA1, Dr. Rakesh Chandra, MD5, Dr. David Conley, MD1, Dr. Stephanie Shintani-Smith, MD1, Dr. Kathryn E. Hulse, PhD5, Dr. Atsushi Kato, PhD3, Dr. Anju T. Peters, MD, FAAAAI3, Dr. Leslie C. Grammer, MD, FAAAAI3, Dr. Robert C. Kern, MD1 and Dr. Robert P. Schleimer, PhD FAAAAI6, 1Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Loyola University Stritch School of Medicine, Chicago, IL, 3Department of Medicine, Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 4Northwestern University- Feinberg School of Medicine, Chicago, IL, 5Northwestern University, Chicago, IL, 6Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL The Prevalence Of AERD In a Tertiary Care Center Dr. Whitney Wyatt Stevens, MD, PhD1, Dr. Anju T. Peters, MD, FAAAAI1, Dr. Kathryn E. Hulse, PhD2, Dr. Leslie C. Grammer,

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MD, FAAAAI1, Dr. Joy Hsu, MD, MSCI1, Prof. Pedro C. Avila, MD, FAAAAI1, Mr. James Norton, MS1, Ms. Lydia Suh, BSc1, Dr. Rakesh Chandra, MD2, Dr. David Conley, MD3, Dr. Robert C. Kern, MD3, Dr. Bruce K. Tan, MD3 and Dr. Robert P. Schleimer, PhD FAAAAI4, 1Department of Medicine, Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Northwestern University, Chicago, IL, 3Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, 4Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL Expression Of Hypoxia-Inducible Factor 1alpha In Regulatory T Cells Is Associated With Nasal Polypogenesis Prof. Yong Min Kim1, Dr. Jun Jin2, Dr. Dong-Yeop Chang3, Sung Ha Kim4 and Ki-Sang Rha4, 1Chungnam National University School of Medicine, Daejeon, South Korea, 2Chungnam National University School of Medicine, 3Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, South Korea, 4Chungnam National University School of Medicine, South Korea Prognoistic Factors For Olfaction After Endoscopic Sinus Surgery In Chronic Sinusitis With Or Without Allergy Dr. Byung Guk KIM1, Jihyun SHIN2, Chan Soon PARK2, Dr. Soo Whan Kim3, JUN Myung Kang2 and So Young PARK2, 1The Catholic University Of Korea, Seoul, Korea, South Korea, 2The Catholic University Of Korea, Seoul, Korea, 3The Catholic University of Korea

SUNDAY

Abstracts AB323

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

Rhinitis 3212 Sunday, March 2nd, 2014, 9:45 AM - 10:45 AM 464

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The Association Between Two SNPs GATA3 (rs1269486, rs2229360) Gene and Allergic Rhinitis Prof. Reza Farid, MD, FAAAAI, Allergy Research Center, Mashhad University of Medical Sciences, Iran, Prof. mohammad Raza Abbaszadegan, 1. Genetic Research Center,Mashhsd University of Medical Science, mashhad, Iran, Prof. Farahzad Jabbari, Allergy research center, Mashhsd University of Medical Science, Mashhad, Iran, Prof. Mehran Gholamin, Immunology Research Center,1. Mashhsd University of Medical Science, mashhad, Iran, Dr. Afshin Shirkani, MD, Bushehr University of Medical Science, Mashhad, Iran, Mrs. Hadis Yousefzadeh, allergy Research Center. Mashhsd University of Medical Science, mashhad, Iran and Ms. Atena Mansouri, buoshar university, Iran Impacts Of Adolescents’ Allergic Rhinitis On School Achievement and Quality Of Life Prof. Sun-Hee Choi, MD, PhD1, Dr. Kyung Suk Lee, MD, PhD2 and Prof. Yeong-Ho Rha, MD, PhD2, 1Gangdong Kyung Hee University Hospital, Seoul, South Korea, 2Kyung Hee University Hospital Allergic Rhinitis (AR) Is Sub-Optimally Controlled: The Need For a More Effective Treatment Option Dr. Phillip L. Lieberman, MD, FAAAAI, Allergy and Asthma Associates, Germantown, TN and Prof. David Price, FRCGP, MRCGP, DRCOG, Research In Real Life, Cambridge, United Kingdom Short and Long-Term Safety Of MP29-02 In The Treatment Of Allergic Rhinitis Dr. William Berger, MD, Allergy & Asthma Associates of Southern California, Mission Viejo, CA, Dr. Jonathan A. Bernstein, MD, FAAAAI, Division of Immunology Allergy & Rheumatology, University of Cincinnati Medical Center, Cincinnati, OH, Dr. Nancy Ruiz, MD, MEDA Pharmaceuticals, Somerset, NJ and Dr. Warner W. Carr, MD, FAAAAI, Allergy and Asthma Associates of SCs, Mission Viejo, CA

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Anti-Allergic Effect Of Intranasal 1,25-Dihydroxyvitamin D3 Treatment In Allergic Rhinitis Mouse Model Dr. Dong-Young Kim, Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL; Department of otorhinolaryngology, Seoul national university college of medicine, Seoul, Korea and Dr. JaeMin Shin, Department of Otorhinolaryngology-Head and Neck Surgery, Soon Chun Hyang University Hospital, Seoul, South Korea B-Cells In Allergic Airways Disease: Inhibition Of Epsilon Transcription By Omalizumab Dr. Marylin Desjardins, MD1,2, Dr. Jean-Philippe Drolet, MD3, Ms. Marianne Beland2, Dr. Sam Daniel, MD1 and Dr. Bruce D. Mazer, MD, FAAAAI1,4, 1Montreal Children’s Hospital, Montreal, QC, Canada, 2Meakins-Christie Laboratories, Montreal, QC, Canada, 3Centre Hospitalier Universitaire de Quebec, Quebec, QC, Canada, 4Meakins-Christie Laboratories, Research Institute McGill University Health Centre, Montreal, QC, Canada Early Childhood Allergic Phenotypes Are Associated With Internalizing Disorders Maya Nanda, MD1, Linda Levin, PhD2, Grace K. LeMasters, PhD2, Amal H. Assa’ad, MD, FAAAAI1, Nicholas Newman, DO, MS1 and Patrick Ryan, PhD1, 1Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2University of Cincinnati, Cincinnati, OH Allergic Rhinitis In Puerto Rican Children: Under-Diagnosis and Risk Factors Dr. Tammy S. Jacobs, MD, MA, Dr. Erick Forno, MD, MPH, Dr. John M. Brehm, MD, MPH, Dr. Yueh-Ying Han, PhD, MS and Dr. Juan C. Celedon, MD, DrPH, FAAAAI, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA Hematopoietic Prostaglandin D Synthase Is a Useful Target For Treating Nasal Obstruction In Guinea Pigs With Allergic Rhinitis Daisuke Kajiwara, Hiroki Aoyagi, Kazuhiko Shigeno, Katsunao Tanaka, Eiji Sasaki and Teruhiro Utsugi, Tsukuba Research Center, TAIHO PHARMACEUTICAL CO.,LTD. Efficacy Of MP29-02 In The Treatment Of Nasal and Ocular Symptoms Of Seasonal Allergic Rhinitis (SAR) Dr. Paul H. Ratner, MD, FAAAAI, Sylvana Research, San Antonio, TX, Dr. Frank Hampel, MD, Central Texas Health Research, Dr. Julius Van Bavel, MD, Allergy and Asthma Research Associates, Austin, TX and Dr. Nancy Ruiz, MD, MEDA Pharmaceuticals, Somerset, NJ Atypical Symptoms Of Chronic Rhinitis and The Impact On Quality Of Life Jettanong Klaewsongkram, Chulalongkorn University, Bangkok, Thailand and Pungjai Mongkolpathumrat, King Chulalongkorn Memorial Hospital, Bangkok, Thailand Clinical Characteristics Of Allergic and Nonallergic Rhinitis In Children Dr. Yong Ju Lee, MD1, Prof. Kyung Won Kim, MD, PhD2, Prof. Myung Hyun Sohn, MD, PhD2, Prof. Kyu-Earn Kim, MD, PhD2 and Prof. Hae-Ran Lee, MD, PhD3, 1Hallym University Kangnam Sacred Heart Hospital, Seoul, South Korea, 2Department of Pediatrics, Severance Children’s Hospital, College of Medicine, Yonsei University, Seoul, Korea, Seoul, South Korea, 3Hallym University Sacred Heart Hospital, Anyang-si, Gyeonggi-do, South Korea

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MD4, Dr. Kelly Bethel5, Ms. Rachel Baum, B.S.4, Mr. Sean Lund, B.S.6, Naseem Khorram, M.S.6, Dr. David R. Scott, M.D.7, Dr. David H. Broide, MB ChB FAAAAI8 and Dr. Taylor A. Doherty, MD, FAAAAI9, 1University of California, San Diego, San Diego, CA, 2Scripps Clinic Medical Group, San Diego, CA, 3 Scripps Clinic, San Diego, CA, 4University of California, San Diego, 5Scripps Green Hospital, 6University of California, San Diego, La Jolla, CA, 7Allergy and Asthma Center of Western Colorado, 8Department of Medicine, San Diego, CA, 9Medicine, University of California, San Diego, San Diego, CA Innate and Adaptive Lymphocyte Responses In a Mouse Model Of Rhinovirus-Induced Asthma Exacerbation Dr. Annabelle Jayaraman, PhD, Dr. Nathan Bartlett, PhD and Prof. Sebastian L. Johnston, MD, PhD, Imperial College London, London, United Kingdom Aspergillus Fumigatus May Promote Th2 Activation By Suppression Of Interferon Signaling Dr. Tetsuya Homma, MD1,2, Mr. Bharat Bhushan1,3, Dr. Atsushi Kato, PhD1, Mr. James Norton, MS1, Ms. Lydia Suh, BSc1, Dr. Quan Sha, MD, PhD4, Dr. Dave S. Gupta, MD5 and Dr. Robert P. Schleimer, PhD FAAAAI6, 1Department of Medicine, Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Department of Internal Medicine, Division of Respiratory Medicine and Allergology, Showa University School of Medicine, Tokyo, Japan, 3Division of OtolaryngologyHead and Neck Surgery, Ann & Robert H. Lurie Children’s Hospital of Chicago, 4Allergy and Immunology research center, Anhui Medical University, China, 5Department of Allergy Immunology, National Jewish Health, Denver, CO, 6Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL Heterogeneity Of Specific CD4+ T Cell Responses To Peanut Allergic Components: Prospects For Specific Immunotherapy Dr. Erik R. Wambre, PhD, Benaroya Research Institute, Seattle, WA, William W. Kwok, PhD, Benaroya Research Institute at Virginia Mason, Seattle, WA and Dr. David Robinson, Virginia Mason Medical Center Vitamin D Supplementation Reduces Th17 Cells In The Lung and Spleen Of CRA-Sensitized and Challenged Mice Ankita Aggarwal1, Greg Perry1, Vikash Kansal2, Min-Jung Kim1 and Devendra K. Agrawal1, 1Department of Medical Microbiology & Immunology and Center for Clinical & Translational Science, Creighton University School of Medicine, Omaha, NE, 2Center for Clinical and Translational Science and Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE Distinct Patterns and Magnitude Of T Cell Responses Are Associated With Seasonal Exposure To Timothy Grass Allergens Dr. Pearl Bakhru1, Carla Oseroff1, Dr. Veronique M. Schulten1, Dr. Denise Hinz1, Victoria Tripple1, Rafeul Alam, MD, PhD, FAAAAI2, Dr. David H. Broide, MB ChB FAAAAI3, Dr. April Frazier1, John Sidney1, Dr. Bjoern Peters1, Dr. Howard Grey1 and Dr. Alessandro Sette, Dr. Biol. Sci.1, 1La Jolla Institute for Allergy and Immunology, La Jolla, CA, 2National Jewish Health, Denver, CO, 3Department of Medicine, San Diego, CA IgE Production In B Cells Through Up-Regulating CD40L Expression and Mediator Release Via CD1d Expressed In Surface Of Mast Cells Related To Allergic Asthma In Mice Jai Youl Ro1, Gwan Ui Hong1, Nam Goo Kim1 and Young Min Ahn2, 1Sungkyunkwan University School of Medicine, 2Eulji University School of Medicine FOXP3 Epigenetic Signature To Distinguish Between Thymicand Peripherally-Derived Regulatory T Cells During In Vivo Induction Of Immune Tolerance Dr. Philippe Begin, MD, MSc FRCPC1,2, Dr. Udo Baron, PhD3, Dr. Sven Olek, PhD3, Dr. Rosa Bacchetta, MD, PhD1,4 and Dr. Kari C. Nadeau, MD, PhD, FAAAAI5, 1Stanford University,

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Pediatric Allergy and Immunology, 2Centre Hospitalier Universitaire Ste-Justine, Montreal, QC, Canada, 3Epiontis GmbH, Berlin, Germany, 4San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Milan, Italy, 5Pediatric Allergy Immunology, Stanford University, Stanford, CA CD4+ and CD8+ T Cells Of Allergic Humans Express Increased Phosphorylated p38 MAP Kinase (p38MAPK), Substance P Suppresses T Cell Expression Of p38MAPK and Memory IgE Responses Bryan McCarthy, BS1, Jonathan I Silverberg, MD, PhD, MPH1, Seto M Chice, MS1, Ankuri Desai, BS1, Dr. Tamar A. Smith-Norowitz, PhD1, Mark Stewart, MD, PhD1, Dr. Rauno Joks, MD2 and Helen G Durkin, PhD1, 1Center for Allergy and Asthma Research at SUNY Downstate, Brooklyn, NY, 2Center for Allergy and Asthma Research, State University of New York Downstate Medical Center, Brooklyn, NY Novel Mechanisms Of Immune Modulation By Alpha-1-Antitrypsin Louise V. Rice1, Sarah Dimeloe1, Mun Peak Nyon2, Imran Haq3, James Irving3, James McDonnell4, Bibek Gooptu2,5, Claudia Kemper6 and Catherine M. Hawrylowicz4, 1MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, King’s College London, London, United Kingdom, 2Institute of Structural and Molecular Biology/Crystallography, London, United Kingdom, 3Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom, 4MRC and Asthma UK Centre for Allergic Mechanisms of Asthma, King’s College London, London, United Kingdom, 5Division of Asthma, Allergy and Lung Biology, King’s College London, London, United Kingdom, 6MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King’s College London, london, United Kingdom Prevalence Of Allergic Diseases and/Or Allergic Sensitization In Children and Adolescents With Type 1 Diabetes Mellitus Dr. Hadley Vila-Nova, MD1, Prof. Angela Spinola-Castro, MD, PhD1, Dr. Fabıola E. Garcia, MD2 and Prof. Dirceu Sole, MD, PhD3, 1Federal University of S~ao Paulo, S~ao Paulo, Brazil, 2Federal UNiversity of S~ao Paulo, S~ao Paulo, Brazil, 3Federal University of Sao Paulo, Sao Paulo, Brazil Microcytosis: A Risk Factor For Asthma and Pulmonary Inflammation? Dr. Emily Brigham, MD, Dr. Meredith C. McCormack, MD, Dr. Clifford Takemoto, MD and Dr. Elizabeth Matsui, MD, The Johns Hopkins University School of Medicine, Baltimore, MD Identification and Cloning Of Active CLC3 Promoter Rohit Gaurav and Devendra K. Agrawal, Department of Biomedical Sciences and Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE

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Airway Epithelial Cells Exposed To Alternaria Release IL-18 Independent Of NALP3/Caspase-1 Pathway By Inducing Autophagy and Nf-Kb Activation Hiroki Murai, MD, PhD1, Shintaro Okazaki, MD1, Hisako Hayashi, MD1, Akiko Kawakita, MD1, Motoko Yasutomi, MD, PhD1, Mitsufumi Mayumi, MD, PhD1, Prof. Sanjiv Sur, MD2 and Yusei Ohshima, MD, PhD1, 1University of Fukui, Fukui, Japan, 2University of Texas Medical Branch, Galveston, TX Generation Of Human Hybridomas Secreting Naturally-Occurring IgE MAbs Using Memory B-Cells From Atopic and Asthmatic Patients Dr. Scott A. Smith, MD, PhD1, Dr. Dennis Horvath, PhD1, Dr. Charles Steven Smith, MD, FAAAAI2, Dr. Dawn C. Newcomb

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Baker, PhD3 and Dr. Ray Peebles, MD4, 1Infectious Diseases; Department of Medicine; Vanderbilt University School of Medicine, Nashville, TN, 2Accredited Asthma and Allergy Care, PCS, Louisville, KY, 3Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, Nashville, TN, 4Allergy, Pulmonary, and Critical Care Medicine; Department of Medicine; Vanderbilt University School of Medicine, Nashville, TN Anti-Viral Innate Immunity Varies Across Different Asthma Inflammatory Phenotypes Prof. John W. Upham, MD, PhD, FAAAAI1, Mrs. Melanie Carroll, BSc1, Prof. Peter Gibson, MD/PhD2,3, Prof. Ian A. Yang, MBBS (Hons) PhD4 and Dr. Jodie Simpson, PhD2, 1University of Queensland, Brisbane, Australia, 2University of Newcastle, Newcastle, Australia, 3John Hunter Hospital, Newcastle, Australia, 4 The University of Queensland Effect Of siRNA Inhibition Of Sialyltransferases and Fucosyltransferases On Siglec-F Ligand Expression By Epithelial Cells In Vitro Dr. Maho Suzukawa, MD, National Hospital Oranization, Tokyo Hospital, Dr. Ken Ohta, National Hospital Organization Tokyo National Hospital, Tokyo, Japan and David Broide, MB ChB, University of California San Diego, Department of Medicine, Division of Allergy and Immunology Allergic Airway Inflammation Can Be Regulated By Semaphorin 4C Through Controlling B-Cell Migration Ms. Di Xue, Mcgill university, Montreal, QC, Canada, Dr. Marylin Desjardins, MD, Division of Allergy and Clinical Immunology, Department of Paediatrics, McGill University Health Centre, Montreal, QC, Canada, Dr. Bruce D. Mazer, MD, FAAAAI, Montreal Children’s Hospital, Montreal, QC, Canada, Dr. Amir Hossein Massoud, PhD, McGill University Health Centre, Montreal, QC, Canada and Ms. Marianne Beland, MUHC, Montreal, QC, Canada Mouse Bone Marrow Derived Mesenchymal Stem Cells Supress Airway Inflammation In Both Chronic and Acute Murine Asthma Model Dr. Tunc Akkoc, PhD1, Mr. Ismail Ogulur, MSc.1, Ms. Gulben Gurhan1, Ms. Ayca Aksoy, MSc.2, Dr. Gokhan Duruksu, PhD2, Dr. Deniz Filinte, MD3, Dr. Erdem Kombak3, Prof. Isil B. Barlan, MD1 and Prof. Erdal Karaoz, PhD2, 1Marmara University Division of Pediatric Allergy-Immunology, 2Kocaeli University Center for Stem Cell and Gene Therapies Research and Practise, 3Marmara University Department of Pathology Profiling Eicosanoids In Breath Condensates Of Asthmatic and Healthy Children Dr. Li-chen Chen1,2, Prof. Jing-Long Huang1,2, Mrs. AI-Hsuan Wu1, Prof. Ming-ling Kuo3 and Prof. Shau-ku Huang4,5, 1ChangGung Memorial Hospital, Taoyuan, Taiwan, 2Chang-Gung University, Taoyuan, Taiwan, 3Department of Microbiology and Immunology, Institute of Basic Medical Science, Taoyuan, Taiwan, 4 Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan, 5Johns Hopkins Asthma and Allergy Center, Baltimore, MD Increased IP-10 Expressions In Nasal Fibroblasts From Patients With Refractory Chronic Rhinosinusitis and Asthma Dr. Mamoru Yoshikawa, MD1, Dr. Kota Wada, MD1, Dr. Tsuyoshi Yoshimura, MD2, Dr. Daiya Asaka, MD2 and Prof. Hiroshi Moriyama, MD2, 1Department of Otorhinolaryngology, Toho University School of Medicine, Tokyo, Japan, 2Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan Vitamin D Regulating TGF-b Induced Epithelial-Mesenchymal Transition Ms. Kimberly Fischer, Creighton University, Omaha and Devendra K. Agrawal, Department of Biomedical Sciences and Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE

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Abstracts AB325

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Macrophage-Derived Chemokine In Nasal Washes Is Associated With Asthma Exacerbations and Infections With Rhinovirus In Children Carolyn R. Word, MD1, Holliday T. Carper, BS1, Patricia Jorge, MD1, Joshua L. Kennedy, MD2, Deborah D. Murphy, RN1, Thomas A.E. Platts-Mills, MD, PhD, FAAAAI3 and Peter W. Heymann, MD1, 1University of Virginia, Charlottesville, VA, 2Arkansas Children’s Hospital Research Institute, Little Rock, AR, 3Division of Asthma, Allergy & Immunology, University of Virginia Health System, Charlottesville, VA Application Of Isoraft Single Cell Isolation For Analysis Of Pediatric Bal Macrophages Dr. Neil Alexis, PhD1, Ms. Heather Wells2, Dr. Yogesh Saini, PhD3, Ms. Louisa Brighton2, Dr. Nancy Allbritton, MD, PhD4 and Dr. Marianne Muhlebach, MD2, 1Center Environmental Med. Asthma/Lung Biology, Chapel Hill, NC, 2Center for Environmental Medicine Asthma and Lung Biology, Chapel Hill, NC, 3CF Center UNC Chapel Hill, Chapel Hill, NC, 4Department of Chemistry UNC Chapel Hill, Chapel Hill, NC 7, 4’-Dihydroxyflavone Isolated From Glycyrrhiza Uralensis a Constituent Of ASHMITM Prevents Dexamethasone Enhancement Of Eotaxin-1 Secretion By Human Lung Fibroblasts Dr. Changda Liu, PhD1, Dr. Nan Yang, PhD, MS1, Mr. Ryan P. Robalino2, Dana Greene2, Janaki Patel2, Jiachen Zi3, Shuwei Zhang3, Dr. Joseph Goldfarb2, Hugh A. Sampson, MD, FAAAAI1, Dr. Jixun Zhan3 and Dr. Xiu-Min Li, MD1, 1Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 2Icahn School of Medicine at Mount Sinai, New York, NY, 3Utah State University Allergen Sensitivities and Obstruction Indices Among Inner City Asthmatic Patients with High IgE (30-700 IU/ml) Vs Ultra-High IgE Levels (>700 IU/ml) Jamie Zacharias, MD1, Dr. Edward S. Schulman, MD, FAAAAI2, Rebanta Chakraborty, MD2, Rozina Ali, DO1 and Natasha Mehta, MD1, 1Division of Internal Medicine, Drexel University College of Medicine, Philadelphia, PA, 2Division of Pulmonary, Critical Care and Sleep Medicine, Drexel University College of Medicine, Philadelphia, PA Alcohol Exposure and Airway Hyperresponsiveness Dr. Christina Cruz, MD1, Dr. Thomas B. Casale, MD, FAAAAI2 and Peter Oldenburg, PhD1, 1Creighton University School of Medicine, Omaha, NE, 2Univeristy Of South Florida Morsani College Of Medicine, Tampa, FL Ragweed Or Dust Mite Antigen-Stimulated Human Primary Bronchial Epithelial Cells Differentially Express Cytokines In Response To Formoterol Or Mometasone Or Their Combination Dr. Anthony Szema, MD, FAAAAI, SUNY Stony Brook School of Medicine, East Setauket, NY; Stony Brook University, Stony Brook, NY, Dr. Sayyed Hamidi, Stony Brook University School of Medicine, Stony Brook, NY, Dr. Ken-Ichi Takemaru, State Univeristy of New York @ Stony Brook, Stony Brook, NY and Marianne Frieri, MD, PhD, FAAAAI, Medicine and Pediatrics, Nassau University Medical Center, East Meadow, NY; State University of NY @ Stony brook, Stony Brook, NY Release Kinetics Of Soluble ST2 and Proinflammatory Cytokines In Allergic Rhinits Mr. Igor Stenin1, Mr. Ralf Baumann1, Mr. Matthaeus Rabaszowski1, Dr. Kathrin I. M. Scheckenbach, MD1, Mr. Pascal Werminghaus1 and Dr. Martin Wagenmann, MD, FAAAAI2, 1Department of Otorhinolaryngology, Head and Neck Surgery, Heinrich-HeineUniversity Duesseldorf, Germany, 2Henrich Heine University, D€ usseldorf, Germany Interaction Between Dietary Antioxidants and Passive Smoking On The Risk Of Asthma Modified By GSTP1(rs1695) Polymorphism Dr. Young-Hwa Song, MD, MPH Candidate1, Hye Lim Shin2, Seo Ah Hong3, Sung-Ok Kwon4, Dr. Young Ho Jung, MD5, Dr.

J ALLERGY CLIN IMMUNOL FEBRUARY 2014

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Eun Lee, MD6, Dr. Song I Yang, MD7, Dr. Ji-Won Kwon, MD8, Dr. Hyung Young Kim, MD9, Dr. Ju-Hee Seo, MD10, Dr. Byoung-Ju Kim, MD, PhD11, Dr. Hyo-Bin Kim, MD, PhD12, SeYoung Oh4, Dr. Soo-Jong Hong, MD, PhD7 and Dr. Bong-Seong Kim, MD13, 1Johns Hopkins Bloomberg School of Public Health, 2 Research Center for Standardization of Allergic Diseases, Asan Institute for Life Sciences, University of ulsan College of Medicine, 3Research Center for Standardization of Allergic Diseases, Asan Institute for Life Sciences, University of ulsan College of Medicine, South Korea, 4Department of Food and Nutrition, College of Human Ecology, Kyung Hee University, 5Childhood Asthma Atopy Center, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, South Korea, 6 Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea, 7Department of Pediatrics, Childhood Asthma Atopy Center, Research Center for Standization of Allergic Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, 8Department of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea, 9Department of Pediatrics, Kosin University Gospel Hospital, Kosin University College of Medicine, Seoul, South Korea, 10Department of Pediatrics, Korea Cancer Center Hospital, 11Department of Pediatrics, Hae-undae Paik Hospital, Inje University College of Medicine, Busan, South Korea, 12Department of Pediatrics,Inje University Sanggye Paik Hospital, Seoul, South Korea, 13Department of Pediatrics, Gangneung Asan Hospital, University of Ulsan College of Medicine Longitudinal Trends Of Food and Environmental Allergen-Specific IgE In Asthmatic Inner-City Children < 4 Years Of Age Dr. Keshav Achar, M.B.B.S1, Yikania Pichardo2, Margaret A. Chin, NP3, Dr. Ramin Nazari, MD4, Dr. Andrew A. Wiznia, MD4 and Dr. Gabriele De Vos, MD5, 1Albert Einstein College of Medicine, NY, 2Jacobi Medical Center, New York, NY, 3Jacobi Medical Center, NY, 4Albert Einstein College of Medicine, 5Albert Einstein College of Medicine, Bronx, NY The Effect Of Human Placental Extract In a Mouse Model Of Allergic Rhinitis Dr. Soo Whan Kim and Dr. Suk-Woo Yang, The Catholic University of Korea Induced Long-Lived Mucosal Mast Cells In The Airways Arise From Circulating Mast Cell Progenitors Dr. Lora Georgieva Bankova, Rheumatology/Immunology/Allergy, Brigham and Women’s Hospital, Boston, MA, Daniel Dwyer, Brigham and Women’s Hospital, Dr. Anne Y. Liu, MD, Stanford University School of Medicine, Palo Alto, CA, Dr. Tatiana Jones, College of Health Science University of Massachusetts, Lowell, MA, Dr. K. Frank Austen, MD, FAAAAI, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA and Dr. Michael Gurish, Brigham and Women’s Hospital/Harvard Medical School, Boston, MA Despite Inflammation, No Structural Upper Airway Remodelling In Severe Allergic Rhinitis Dr. Aarif Eifan, MD1, Dr. Nara Orban, MD2, Dr. Mikila Jacobson, PhD2 and Prof. Stephen R. Durham, MA MD FRCP2, 1Imperial College London, United Kingdom, 2Imperial College London, London, United Kingdom Ozone Inhalation Induces Epithelial IL-33 and Thymic Stromal Lymphopoietin (TSLP) and Leads To Eosinophilic Airway Inflammation Stephanie Kubala1,2, Moyar Q. Ge2, Imre Redai2, Monica Soni2,3, Dr. Bei Chen, MD2, Dr. Qi Yang, PhD2, Dr. Avinash Bhandoola, MBBS PhD2, Dr. Noam A. Cohen, MD, PhD2 and Dr. Angela Haczku, MD, PhD, FAAAAI2, 1Temple University School of Medicine, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA, 3Georgetown University

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Clinical Efficacy Of Subcutaneous and Sublingual Immunotherapy In Asthma and Rhinitis Children Sensitized To House Dust Mite Min-Ju Kim1,2, Eun Lee1,3, Keun-Mi Park1, Keum-Hee Hwang1, Young-Ho Jung1,3, Song-Yi Yang1,4, Jae-Eun Lee2, HeeKyeong Kim2, Hye-yeong Lee2, Jin-ho Yu1 and Prof. Soo-Jong Hong, MD. PhD1,3, 1Childhood Asthma Atopy Center, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, South Korea, 2Department of Children’s Hospital Nursing, Asan Medical Center, South Korea, 3Research Center for Standardization of Allergic Disease, University of Ulsan College of Medicine, Seoul, Korea, 4Research Center for Standardization of Allergic Disease, University of Ulsan College of Medicine, Seoul, Korea, South Korea A Patient-Reported Symptom-Based Predictor Of Objective Sinus Inflammation Ms. Alcina K. Lidder, BA1, Dr. Rakesh Chandra, MD2, Dr. David Conley, MD1, Dr. Stephanie Shintani-Smith, MD1, Dr. Anju T. Peters, MD, FAAAAI3, Dr. Leslie C. Grammer, MD, FAAAAI3, Dr. Robert C. Kern, MD1, Dr. Brian Schwartz, MD4,5 and Dr. Bruce K. Tan, MD1, 1Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Northwestern University, Chicago, IL, 3Department of Medicine, Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 4Center for Health Research, Geisinger Clinic, Danville, PA, 5Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Healthcare Providers’ Perception Versus Reality In Patient Concerns About Starting Subcutaneous Immunoglobulin Ms. Carla M. Duff, CPNP MSN1, Ms. Annette R. Zampelli, NP2 and Dr. Ann Bullinger, PharmD2, 1University of South Florida, Tampa, FL, 2CSL Behring, LLC, King of Prussia, PA Anaphylaxis During Obstetric Surgery In Latex Allergic Patients Dr. Nana Jinjolava, MD1, Dr. *Mili Shum, MD2, Dr. Keshav Achar1, Dr. Ren Zhen1 and Dr. Elina Jerschow, MD, M.Sc.3, 1Albert Einstein College of Medicinen, 2Montefiore Medical Center, Bronx, NY, 3Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY The Impact Of Legislation On Illinois School Nurses Ms. Christine Szychlinski, APN, CPNP1, Mrs. Katherine A. Schmeissing, MS, R.N.2, Dr. Jacqueline Pongracic, MD, FAAAAI2 and Dr. Anne Marie Singh, MD3, 1Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 2Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 3Division of Allergy & Immunology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL

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Socio-Demographic and Environmental Correlates Of Exhaled Nitric Oxide Levels Dr. Lakiea S Wright, MD MAT, Brigham and Women’s Hospital Division of Rhematology, Immunology & Allergy, Boston, MA; Boston Children’s Hospital Division of Allergy and Immunology, Boston, MA, Dr. Wanda Phipatanakul, MD, MS, FAAAAI, Boston Children’s Hospital, Boston, MA and Jessica Rabe Savage, MD ,

Brigham and Women’s Hospital, Division of Rheumatology, Immunology and Allergy, Boston, MA Relationships Between The New Biomarkers Induced By Interleukin-13 and Bronchial Hyperresponsiveness In Asthmatic Children: Periostin and Squamous Cell Carcinoma-Related Antigens Prof. Heysung Baek, MD, PhD1, Prof. Kenji Izuhara, MD, PhD2 and Dr. Jeong-Sub Yoo1, 1Department of Pediatrics, Hallym University College of Medicine, Seoul, South Korea, 2Saga Medical School, Saga, Japan Exhaled Nitric Oxide Performance Compared To Methacholine Challenge In Asthma Andrew Nickels, MD, Dr. Kaiser G. Lim, MD, FAAAAI, Dr. Paul Scanlon, MD and Kenneth Parker, Mayo Clinic, Rochester, MN Serum Interleukin 13 (IL-13) and Surfactant Protein D (SP-D) Expression Is Differentially Associated With Disease Status In Pediatric Asthma Patients Dr. Vasiliki Gemou-Engesaeth, MD, PhD1, Dr. N Laliotou, MD1, Prof. Chris J. Corrigan, MD, PhD, FAAAAI2, Prof. George P. Chrousos, MD, PhD1 and Dr. Angela Haczku, MD, PhD, FAAAAI3, 1 National & Kapodistrian University of Athens, Greece, 2King’s College London School of Medicine, London, United Kingdom, 3 University of Pennsylvania, Philadelphia, PA Correlation Of Exhaled Breath Temperature With Age In Chronic Respiratory Diseases Dr. Radoslaw Gawlik, MD1, Dr. Malgorzata Rajzer-Wrobel2, Dr. Dariusz Ziora2 and Prof. Lawrence M. DuBuske, MD, FAAAAI3, 1 Silesian Medical University, Katowice, Poland, 2Silesian Medical University, Poland, 3George Washington University School of Medicine, Washington, DC

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Abstracts AB327

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

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Peripherally Induced Foxp3+ Regulatory T Cells Mediates The Immunomodulatory Effect Of Intravenous Immunoglobulin In An Experimental Model Of Allergic Airway Disease Dr. Amir Hossein Massoud, PhD1,2, Mr. Gabriel N. Kaufman, MSc1,2, Dr. Ciriaco Piccirillo, PhD2 and Dr. Bruce D. Mazer, MD, FAAAAI1,3, 1Meakins-Christie Laboratories, Research Institute - McGill University Health Centre, Montreal, QC, Canada, 2 McGill University Health Centre, Montreal, QC, Canada, 3Montreal Children’s Hospital, Montreal, QC, Canada Differential DNA Methylation In Mothers Increases The Prevalence Of Atopic Dermatitis In Their Offspring Dr. Pia J. Hauk, MD1, Mrs. Anna Forssen, MS1, Dr. Brent Pedersen, PhD2, Dr. Matthew Strand, PhD1, Mrs. Lindsay Munoz, BA1, Dr. Michaela Schedel, PhD1, Dr. Anne Lynch, MD, MSPH2, Dr. Virginia Winn, MD, PhD2, David A. Schwartz, MD3 and Dr. Erwin W. Gelfand, MD, FAAAAI1, 1National Jewish Health, Denver, CO, 2 University of Colorado Denver, Aurora, CO, 3University of Colorado Denver School of Medicine, Aurora, CO Hypereosinophilia In Children and Adults: A Retrospective Comparison Kelli Williams, MD, M.P.H., JeanAnne Ware, CRNP, Annalise Abiodun, RN, Paneez Khoury, MD and Dr. Amy D. Klion, MD, National Institutes of Health, Bethesda, MD Interleukin 35 Modulates TSLP, IL-25 and IL-33 Primed Dendritic Cells and Inhibits Naive T Cell Differentiation and Grass Pollen-Specific T Cell Proliferation Natalia C Couto-Francisco1, Dr. Tomokazu Matsuoka2,3, Ms. Rachel Yan, RN3, Prof. Stephen R. Durham, MA MD FRCP1 and Dr. Mohamed H. Shamji, BSc MSc PhD4, 1Imperial College London,

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London, United Kingdom, 2Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, UK, United Kingdom, 3Imperial College London, United Kingdom, 4Imperial College London, South Kensington, United Kingdom Fc-Gamma-Receptor-IIb Is Required For The Immunomodulatory Actions Of Intravenous Immune Globulin In An AntigenDriven Murine Model Of Allergic Airways Disease Mr. Gabriel N. Kaufman, MSc1, Dr. Amir Hossein Massoud, PhD1, Dr. Ciriaco A. Piccirillo, PhD2 and Dr. Bruce D. Mazer, MD, FAAAAI1,3, 1Meakins-Christie Laboratories, Research Institute - McGill University Health Centre, Montreal, QC, Canada, 2 Centre for the Study of Host Resistance, Research Institute McGill University Health Centre, Montreal, QC, Canada, 3Montreal Children’s Hospital, Montreal, QC, Canada

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Endotoxin In Size-Specific Airborne Particles Induces Differential Nitrative Stress In Human Bronchoepithelial Cells Umesh Singh1, Dr. Jonathan A. Bernstein, MD, FAAAAI1, Kristin Luther2, Lauren Haar2 and Dr. W. Keith Jones, PhD2, 1Division of Immunology Allergy & Rheumatology, University of Cincinnati Medical Center, Cincinnati, OH, 2Department of Medicine and Pharmacology & Cell Biophysics, University of Cincinnati Medical Center, Cincinnati, OH High Rates Of Sensitization To Selected Metals and Bone Cement In Joint Replacement Failure Patients and Preoperative Evaluations Dr. Karin A. Pacheco, MD, MSPH FAAAAI, Dr. Annyce Mayer, MD, MSPH, Ms. Samantha Erb, MS, Dr. Lata Shirname-More, PhD and Dr. Lisa A. Maier, MD, MSPH FCCP, National Jewish Health, Denver, CO Component Resolved Diagnosis In Baker’s Asthma Ms. Cristina Gomez-Casado1, Dr. Paloma Campo, MD, PhD2, Dr. Maria Garrido, PhD3, Ms. C Pereira4, Dr. Arantxa Palacin, PhD1, Dr. La Rivas4, Dr. M Catarino5, Dr. Ana Aranda, PhD6, Maria Luisa Macias6, Dr. Alicia Armentia, MD, PhD7, Dr. S. Quirce, MD, PhD8, Dr. Miguel Blanca, MD, PhD2 and Araceli Diaz Perales1, 1Centre for Plant Biotechnology and Genomics (UPM-INIA), Madrid, Spain, 2Allergy Service, Carlos Haya Hospital, Malaga, Spain, 3 Plant Biotechnology Institute (UPM-INIA), Madrid, Spain, 4Molecular Evolution Laboratory, Astrobiology Centre (INTA-CSIC), Madrid, Spain, 5Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal, 6Research Laboratory, Carlos Haya Hospital-FIMABIS, Malaga, Spain, 7Valladolid University, Valladolid, Spain, 8Hospital La Paz Institute for Health Research (IdiPaz), Allergy department., Madrid, Spain Endotoxin Exposure May Protect Against The Development Of Rhinoconjunctivitis and Respiratory Symptoms In Non-Atopic Individuals With Occupational Exposure To Mice Dr. Sharon K. Ahluwalia, MD1,2, Dr. Roger Peng, PhD3, Mr. Charles Aloe, MPH2, Wayne G. Shreffler, MD, PhD, FAAAAI4,5, Mary Krevans, RN6, Karol A. Hagberg, BSN FNP6, Dr. Peter S. Thorne, PhD7, Kenneth Walsh8 and Dr. Elizabeth Matsui, MD9, 1 Children’s National Medical Center, Washington, DC, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3Johns Hopkins School of Public Health, Baltimore, MD, 4Massachusetts General Hospital, Boston, MA, 5Harvard Medical School, Boston, MA, 6The Jackson Laboratory, Bar Harbor, ME, 7 University of Iowa, Iowa City, IA, 8The Jackson Laboratories, ME, 9The Johns Hopkins University School of Medicine, Baltimore, MD

Sensitization To Occupational Allergens and Allergic Diseases In Workers Of 5 Havana Bakeries Dr. Mirta Alvarez, MD1, Dr. Alexis Labrada, PhD2, Raul Lazaro Castro Almarales, MD3, Mrs. Yaquelın Leyva1, Mr. Victor R Meli4, Dr. Humberto Barata4 and Dr. Miguel Hinojosa5, 1Calixto Garcıa University Hospital, Cuba, 2National Center of Bioproducts, Havana, Cuba, 3National Center of Bioproducts, Cuba, 4Diater Laboratories, Argentina, 5Ramon y Cajal Hospital, Spain

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Safety Of Propofol Use In Patients With Food Allergies Dr. Harshna Mehta, MD, The Icahn School of Medicine at Mount Sinai, New York, NY and Dr. Mirna Chehade, MD, MPH, Icahn School of Medicine at Mount Sinai, New York, NY; Mount Sinai Center of Eosinophilic Disorders, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY Risk Stratification Protocol For Carboplatin and Oxaliplatin Hypersensitivity Reactions With Repeat Skin Testing Improves Care Dr. Alberta L. Wang, MD1, Dr. Sarita U. Patil, MD2, Dr. Aidan Long, MD, FAAAAI2 and Dr. Aleena Banerji, MD2, 1Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA Added Value Of Skin Testing In Hypersensitivity Reactions To Taxanes Dr. Matthieu Picard, MD1, Dr. Leyla Pur, MD1, Dr. Joana Caiado, MD1, Prof. Pedro Giavina-Bianchi, MD, PhD, FAAAAI2, Dr. Violeta Galv~ao, MD1 and Dr. Mariana C. Castells, MD, PhD, FAAAAI1, 1Division of Rheumatology, Allergy and Immunology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 2Clinical Imunnology and Allergy Division, University of Sao Paulo, Boston, MA Risk Stratification For Paclitaxel-Induced Hypersensitivity Reactions Improves Quality Of Care Dr. Timothy P. Lax, MD, Dr. Aleena Banerji, MD, Dr. Johnson T. Wong, MD, FAAAAI, Dr. Michael T. Wilson, MD, PhD and Dr. Aidan Long, MD, FAAAAI, Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA Healthcare Utilization and Serious Infection Prevalence Associated With Penicillin ‘‘Allergy’’ In Hospitalized Patients: A Cohort Study Dr. Eric M. Macy, MD, FAAAAI, 5th Floor, SCPMG-Kaiser Permanente San Diego, San Diego, CA and Richard Contreras, MS, Kaiser Permanente Health Care Program, Department of Research and Evaluation, Pasadena, CA

Oral Immunotherapy for Food Allergy 3605 Sunday, March 2nd, 2014, 2:45 PM - 4:00 PM 536

Length Of Avoidance Period Following Peanut Oral Immunotherapy Influences Effector Cell Suppression and Clinical Outcomes Michael D. Kulis Jr., PhD, Dr. Rishu Guo, PhD, Brian P. Vickery, MD, FAAAAI, Pamela H. Steele, MSN CPNP AE-C, Edwin Kim, MD, MS and A. Wesley Burks, MD, FAAAAI, University of North Carolina at Chapel Hill, Chapel Hill, NC

Abstracts AB329

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

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Basophil Hyporesponsiveness To Peanut Following Immunotherapy May Be Transient and Correlates With Clinical Response Dr. Mark Gorelik, MD1, Dr. Satya Narisety, MD1, Kristin Chichester, MS1, Anja Bieneman, BS1, Corinne Keet, MD, MS2, Robert A. Wood, MD, FAAAAI2, Dr. John T. Schroeder, PhD1 and Pamela Frischmeyer Guerrerio1, 1Johns Hopkins University School of Medicine, 2Johns Hopkins University Medical Center, Baltimore, MD Safety Of Pediatric Peanut Oral Immunotherapy Is Complicated By High Adverse Event Rates Yamini Virkud, MD, MA1, Brian P. Vickery, MD, FAAAAI2, Pamela H. Steele, MSN CPNP AE-C2, Janet S. Kamilaris, RN3 and A. Wesley Burks, MD, FAAAAI2, 1Duke University, Durham, NC, 2 University of North Carolina, Chapel Hill, NC, 3Carolinas Health Care System, Charlotte, NC Course and Outcome Of Patients With Asthma During Oral Immunotherapy To Cow’s Milk Protein Dr. Arnon Elizur, MD1,2, Dr. Michael Goldberg, MD, PhD1, Dr. Michael Levy, MD, FAAAAI1, Dr. Liat Nachshon, MD1 and Prof. Yitzhak Katz, MD, FAAAAI1,2, 1Assaf Harofeh, Zerifin, Israel, 2 Tel Aviv University, Tel Aviv, Israel B-Fahf-2 Pretreatment Reduces OIT Adverse Reactions and Improves Outcomes In a Murine Model Of Multiple Nut Allergy Dr. Xiu-Min Li, MD, Dr. Ying Song, MD, Dr. Changda Liu, PhD, Mr. Ilan Goldberg, Hugh A. Sampson, MD, FAAAAI and Dr. Kamal D. Srivastava, PhD, Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY

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Adherence 3606 Sunday, March 2nd, 2014, 2:45 PM - 4:00 PM 541

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Adherence Documentation During Asthma Encounters At a Pediatric Tertiary Care Referral Center Kara J. Wada, MD, Nationwide Children’s Hospital and The Ohio State University, Columbus and David R. Stukus, MD, FAAAAI, Nationwide Children’s Hospital, Columbus, OH High-Risk Asthma Multidisciplinary Care Clinic Adherence Linked To Asthma Control Test (ACT) Score Improvement Dr. Bradley A. Locke, DO1, Dr. Pippa Simpson, PhD1, Mrs. Tina Bromberger, RN, BSN, AE-C2, Mrs. Melodee Nugent, MA1, Mrs. Sara A. Lowe, NP1, Dr. Juan Ruiz, MD1, Dr. Patricia Marik, PsyD2, Dr. Jacquelyn Smith, PhD2, Dr. Joshua A. Steinberg, MD1 and Dr. Dorothy S. Cheung, MD, FAAAAI1, 1Medical College of Wisconsin, Milwaukee, WI, 2Children’s Hospital of Wisconsin, Milwaukee, WI Understanding Asthma Medical Nonadherence In Adult and Pediatric Populations Joyce Xiang Wu Lee, MD1, Henry Wojtczak, MD2, Allan M. Wachter, MD3, Martin Lee, PhD4, Lisa Burns, RN3, Diana Chen3 and Joseph S. Yusin, MD, FAAAAI5, 1Allergy/Immunology, VA Greater Los Angeles Health Care System, Los Angeles, CA, 2Naval Medical Center San Diego, San Diego, CA, 3Foundation for Asthma Research and Intervention, Phoenix, AZ, 4UCLA School of Public Health, Los Angeles, CA, 5VA Greater Los Angeles Health Care System, Los Angeles, CA Improved Education and Self-Management In Children and Adolescents With Asthma Using a Personalized Smartphone Application David R. Stukus, MD, FAAAAI1,2, Gary Phillips, M.A.S.1 and Nabeel Farooqui, MD1,2, 1Wexner Medical Center at The Ohio State University, Columbus, OH, 2Nationwide Children’s Hospital, Columbus, OH

Misuse Of Medical Devices Among Patients In a Tertiary Care Allergy/Immunology Practice Dr. Rana S. Bonds, MD, FAAAAI, University of Texas Medical Branch, Galveston, TX and Dr. Aasia I. Ghazi, MD, Allergy and Asthma Specialists, Plano, TX

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B Cells and Plasma Cells Populations Suffer Changes Along The Time After Dermatophagoides Pteronyssinus Specific Immunotherapy Dr. Enrique G! omez, PhD1, Dr. Tah!ıa Fern!andez, PhD2, Dr. Inmacuomez, MD, PhD3, Mrs. Luisa lada Do~ na, MD, PhD3, Dr. Francisca G! 3 Galindo, RN , Ms. Lidia Melendez, Lab. Tech.4, Dr. Miguel Blanca, MD, PhD3, Dr. Cristobalina Mayorga, PhD5 and Dr. Maria Jos!e Jose Torres, MD, PhD3, 1Research Laboratory for Allergic Diseases, Hospital Regional Universitario de Malaga - IBIMA, M!alaga, Spain, 2Research Laboratory - FIMABIS Foundation, M!alaga, Spain, 3Allergy Service, Carlos Haya Hospital, M!alaga, Spain, 4Research Laboratory, Carlos Haya Hospital-FIMABIS, Malaga, Spain, 5Research Laboratory, Carlos Haya Hospital-FIMABIS, M!alaga, Spain A Subset Of Novel Timothy Grass Antigens Is Associated With Marked Th1/Th2 Shifts Following Specific Immunotherapy Dr. Veronique M. Schulten1, Victoria Tripple1, John Sidney1, Dr. Jason Greenbaum1, Dr. April Frazier1, Rafeul Alam, MD, PhD, FAAAAI2, Dr. David H. Broide, MB ChB FAAAAI3, Dr. Howard Grey1, Dr. Bjoern Peters1 and Dr. Alessandro Sette, Dr. Biol. Sci.1, 1La Jolla Institute for Allergy and Immunology, La Jolla, CA, 2National Jewish Health, Denver, CO, 3Department of Medicine, San Diego, CA Interleukin IL-27+ Dendritic Cells Modulate Ex-Vivo Th2 Responses In a Pdl-1-Dependent Manner and Increase In-Vivo Following Grass Pollen Immunotherapy Dr. Tomokazu Matsuoka1, Ms. Rachel Yan, RN2, Dr. Guy W Scadding, MD2, Prof. Stephen R. Durham, MA MD FRCP3 and Dr. Mohamed H. Shamji, BSc MSc PhD4, 1Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, UK, United Kingdom, 2Imperial College London, United Kingdom, 3Imperial College London, London, United Kingdom, 4 Imperial College London, South Kensington, United Kingdom Local ‘Protective’ IgG4 Antibodies In Nasal Fluid Are Elevated Following Grass Pollen Immunotherapy Jinjin Zhang1, Dr. Esther Steveling2, Ms. Rachel Yan, RN2, Dr. Aarif Eifan, MD2, Rebecca Parkin3, Dr. Guy W Scadding, MD2, Dr. Mohamed H. Shamji, BSc MSc PhD4 and Prof. Stephen R. Durham, MA MD FRCP1, 1Imperial College London, London, United Kingdom, 2Imperial College London, United Kingdom, 3Imperial College London, London, 4Imperial College London, South Kensington, United Kingdom Grass Pollen Immunotherapy: Impaired Allergen-Induced Nasal and Cutaneous Responses Correlate With Overall Seasonal Symptom Scores and Are Associated With Suppressed Local Th2 Cytokines In Nasal Fluid Dr. Guy W Scadding, MD1, Dr. Aarif Eifan, MD1, Dr. Mongkol Lao-Araya, MD1, Dr. Martin J. Penagos Paniagua, MD1, Ms. Shun Yan Poon1, Dr. Esther Steveling1, Ms. Andrea Goldstone, RN1, Ms. Rachel Yan, RN1, Ms. Amy Switzer1, Dr. Deborah Phippard2, Dr. Mohamed H. Shamji, BSc MSc PhD3 and Prof. Stephen R. Durham, MA MD FRCP4, 1Imperial College London, United Kingdom, 2Immune Tolerance Network, 3Imperial College London, South Kensington, United Kingdom, 4Imperial College London, London, United Kingdom

SUNDAY

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J ALLERGY CLIN IMMUNOL FEBRUARY 2014

Mechanisms of Eosinophil-Driven Disease

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IL-4 and IL-13 Differentially Regulate TLR-Induced Eosinophil-Basophil Differentiation Of Cord Blood CD34+ Progenitor Cells Dr. Pia Reece, PhD1, Dr. Roma Sehmi, PhD FAAAAI1 and Judah Aryeh Denburg, MD, FRCPC, FAAAAI2, 1McMaster University, Hamilton, ON, Canada, 2Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, ON, Canada Basophils Act As a Cellular Switch to Drive Eosinophilic Inflammation after IgE Activation Dr. Laurence E. Cheng, MD, PhD, University of California, San Francisco Medical Center, San Francisco, CA and Prof. Richard M. Locksley, MD, University of California, San Francisco, HHMI, San Francisco, CA The SNARE VAMP-7 Contributes To Eosinophil Degranulation, In Vivo Dr. Paige Lacy, PhD FAAAAI1, Dr. Lian Willetts, PhD1, Dr. Elizabeth Jacobsen, PhD2, Dr. Rachel Condjella, PhD2, Ms. Katie Zellner2, Dr. Sergei Ochkur, PhD2, Mr. Hui Lou2, Mr. Will LeSuer2, Mr. John Kim, MSc1, Ms. Cheryl Protheroe2, Mr. Ralph Pero2, Dr. James J. Lee, PhD3, Dr. Nancy A. Lee, PhD2 and Dr. Redwan Moqbel, PhD FRCPath FAAAAI4, 1University of Alberta, Edmonton, AB, Canada, 2 Mayo Clinic Arizona, Scottsdale, AZ, 3Mayo Clinic of Arizona, Scottsdale, AZ, 4University of Manitoba, Winnipeg, MB, Canada Microbiota Regulates Eosinophils In The Small Intestine Dr. Rodrigo Jimenez-Saiz, PhD1, Mrs. Tina Walker-Fattouh1, Mrs. Melissa E. Gordon, MSc1, Mr. Waleed S. Ahmed1, Ms. Breanne Dale1, Mr. Talveer S. Mandur1, Mr. Joshua Kong1, Mr. Derek K. Chu1, Dr. Roland Kolbeck, PhD2, Dr. Alison A. Humbles, PhD2, Dr. Elena F. Verdu, MD, PhD3 and Dr. Manel Jordana, MD, PhD1, 1McMaster Immunology Research Centre (MIRC), McMaster University, Hamilton, ON, Canada, 2Medimmune LCC, Gaithersburg, MD, 3Farcombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada The Airway Mucins Muc5b and Muc4 Are Endogenous Ligands For Siglec-F and Induce Mouse Eosinophil Death Takumi Kiwamoto, MD, PhD1, Toshihiko Katoh, PhD2, Christopher Evans, PhD3, Mary E. Brummet, MS1, Sherry Hudson, MS1, Zhou Zhu, MD, PhD1, Michael Tiemeyer, PhD2 and Bruce S. Bochner, MD, FAAAAI1, 1Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, 2 Complex Carbohydrate Research Center, University of Georgia, Athens, GA, 3Division of Pulmonary Medicine, University of Colorado School of Medicine, Denver, CO

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Featured Poster Session Best of ADT 3801 Sunday, March 2nd, 2014, 4:00 PM - 6:00 PM 556

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Impact Of Asthma Exacerbations On Lung Function In a Large Cohort Of Patients With Severe Or Difficult-To-Treat Asthma Dr. Theodore A. Omachi1, Dr. Tmirah Haselkorn1, Dave P. Miller2 and Dr. William J. Calhoun, MD, FAAAAI3, 1Genentech, Inc., South San Francisco, CA, 2ICON Clinical Research, 3Allergy And Immunology, University of Texas Medical Branch, Galveston, TX

Analysis Of Severe Asthma Phenotypes By Using High-Resolution Computed Tomography: Relation To Clinical Assessment Sujeong Kim1, Kwang-Nam Jin2, Chang Hyun Lee2, Prof. So-Hee Lee3, Jae-Won Jung4, Prof. Woo-Jung Song, M.D.1, Prof. HyeRyun Kang1, Kyung-Up Min1 and Prof. Sang Heon Cho, MD, PhD3, 1Department of Allergy and Clinical Immunology, Seoul National University College of Medicine, Seoul, South Korea, 2Department of Radiology, Seoul National University College of Medicine, Seoul, South Korea, 3Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, 4Inje university ilsan paik hospital, Seoul, South Korea Associations Between The Expression Of Corticosteroid Regulated Genes By Peripheral Blood Mononuclear Cells (PBMCs) In Children From The NIH/NIAID Sponsored Asthma Phenotypes In The Inner City (APIC) Study Dr. Elena Goleva, PhD1, Leisa P. Jackson, BS1, Baomei Shao, BS2, Zheng Hu, BS2, Dr. Michelle A. Gill, MD, PhD2, Andrew H. Liu, MD1 and Donald Y.M. Leung, MD, PhD, FAAAAI1, 1National Jewish Health, Denver, CO, 2UT Southwestern Medical Center, Dallas, TX Bronchial Mast Cell Markers and Clinical Asthma Severity In Steroid Refractory Asthmatics Dr. Mandeep Hundal, M.D.1, Dr. Katherine N. Cahill, MD2, Robert Pedicini1, Allison Crosby-Thompson1, Stefanie Dutile1, Usha Govindarajulu, PhD2, Dr. Kartik Shenoy, M.D.3, Dr. Mark Dransfield4, Dr. Emily DiMango5, Dr. Serpil C. Erzurum, M.D.6, Dr. Mario Castro, MD, MPH7, Dr. Nizar N. Jarjour, MD8, Dr. Howard Katz, PhD2, Dr. Joshua A. Boyce, MD, FAAAAI2 and Dr. Elliot Israel, MD, FAAAAI1, 1Brigham and Women’s Hospital, Boston, MA, 2Brigham and Women’s Hospital, Division of Rheumatology, Immunology and Allergy, Boston, MA, 3Temple University School of Medicine, 4University of Alabama School of Medicine, AL, 5Columbia University, New York, NY, 6Department of Pathobiology, Cleveland Clinic, 7Washington University School of Medicine, St. Louis, MO, 8University of Wisconsin School of Medicine and Public Health, Madison, WI Antagonistic Effects Of Ozone (O3) Exposure and Glucocorticoid Treatment On Airway Hyperresponsiveness (AHR) and Surfactant Protein D (SP-D) Production In Mice Moyar Q. Ge1,2, Monica Soni1, Imre Redai1, Blerina Kokalari1, Dr. Angela Haczku, MD, PhD, FAAAAI1 and Zhilong Jiang1, 1University of Pennsylvania, Philadelphia, PA, 2National University of Singapore, Singapore, Singapore

Impaired Glycosylation Due To Autosomal Recessive PGM3 Mutations Results In Atopy, Immune Deficiency, Autoimmunity, and Neurocognitive Impairment Dr. Joshua D. Milner, MD1, Dr. Jonathan J. Lyons, MD1, Dr. Yu Zhang, PhD2, Dr. Xiaomin Yu, PhD1, Dr. Shrimati Datta, PhD1, Ian T. Lamborn, BSc2, Matthew R. Biancalana, BSc3, Lynne A. Wolfe, CRNP4, Thomas DiMaggio, BSN2, Helen F. Matthews, BSN3, Dr. Sarah M. Kranick, MD5, Dr. Kelly D. Stone, MD, PhD, FAAAAI1, Dr. Steven M. Holland, MD6, Dr. Daniel S. Reich, MD, PhD7, Dr. Jason D. Hughes, PhD8, Dr. Huseyin Mehmet, PhD8, Dr. Joshua McElwee, PhD8, Dr. Hudson H. Freeze, PhD9, Dr. Alexandra F. F. Freeman, MD6 and Dr. Helen C. Su, MD, PhD2, 1Laboratory of Allergic Diseases, NIAID/NIH, Bethesda, MD, 2Laboratory of Host Defenses, NIAID/NIH, Bethesda, MD, 3 Laboratory of Immunology, NIAID/NIH, Bethesda, MD, 4Undiagnosed Diseases Program, NHGRI/NHI, Bethesda, MD, 5Medical

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Neurology Branch, NINDS/NIH, Bethesda, MD, 6Laboratory of Clinical Infectious Diseases, NIAID/NIH, Bethesda, MD, 7Neuroimmunology Branch, NINDS/NIH, Bethesda, MD, 8Merck Research Laboratories, Merck & Co. Inc., Boston, MA, 9Sanford Burnham Medical Research Institute, La Jolla, CA Expansion Of Circulating T Follicular Helper Cells In CVID Patients With Autoimmune Cytopenias Dr. Neil D. Romberg, MD1, Dr. Ida Hsu, MD1, Dr. Christina C. Price, MD1, Dr. Charlotte Cunningham-Rundles, MD, PhD, FAAAAI2 and Dr. Eric Meffre, PhD1, 1Yale University School of Medicine, New Haven, CT, 2Mt. Sinai Medical Center, New York, NY Treatment Of Murine Chronic Granulomatous Disease (CGD) With The PPARg Agonist Pioglitazone Enhances Phagocyte Mitochondrial Reactive Oxygen Species (ROS) Production and Antimicrobial Responses Dr. Donna Bratton, MD, Dr. S. Courtney Frasch, PhD, Dr. Kenneth Malcolm, PhD and Dr. Ruby Fernandez-Boyanapalli, PhD, National Jewish Health, Denver, CO Patient Specific Targeted Gene Therapy In The Treatment Of X-Linked Hyper-IgM Syndrome Caroline Y. Kuo, M.D., Division of Allergy and Immunology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, Alok Joglekar, PhD, Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA and Donald B. Kohn, MD, Department of Pediatrics and Department of Microbiology, Immunology, and Molecular GeneticsUniversity of California, Los Angeles, Los Angeles, CA Digeorge Syndrome Found By SCID Newborn Screening In California Dr. Kiran P. Patel, MD, MS1, Dr. Antonia Kwan, PhD, MRCPCH1, Mica Muskat, MSN1, Dr. Joseph A. Church, MD, FAAAAI2, Dr. Morna J. Dorsey, MD MMSc FAAAAI1 and Dr. Jennifer M. Puck, MD1, 1Department of Pediatrics, University of California San Francisco and UCSF Benioff Children’s Hospital, San Francisco, CA, 2 Department of Pediatrics, University of Southern California and Children’s Hospital Los Angeles, Los Angeles, CA

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Urinary Levels Of Phytoestrogens Are Inversely Associated With Wheezing, Asthma, and Atopy Juan-Carlos Cardet, MD, Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, Christina Johns, BA, Brigham and Women’s Hospital, Boston, MA and Jessica Rabe Savage, MD , Brigham and Women’s Hospital, Division of Rheumatology, Immunology and Allergy, Boston, MA Vitamin D Treatment Is Protective Of Inhalant Organic DustInduced Bone Loss Dr. Jill A. Poole, MD, FAAAAI1, Anand Dusad1, Dr. Todd Wyatt, PhD2, Angela Gleason, MA1, Michael Duryee1, Elizabeth Klein1, Christopher Bauer1, Dr. Lynell Klassen, MD1, Dr. Ted Mikuls, MD1, Dr. William West, MD1, Dr. Debra Romberger, MD2 and Dr. Geoffrey Thiele, PhD1, 1University of Nebraska Medical Center, Omaha, NE, 2UNMC, Omaha, NE Antigenic Determinants On Der p 1 Identified By Mutagenesis Analysis Based On The Structure Of Allergen-Antibody Complexes Dr. Anna Pomes, PhD FAAAAI1, Ms. Jill Glesner1, Ms. Lisa D. Vailes1, Dr. Wladek Minor, PhD2, Dr. Maksymilian Chruszcz, PhD3 and Dr. Martin D. Chapman, PhD FAAAAI1, 1Indoor

Biotechnologies, Inc., Charlottesville, VA, 2University of Virginia, Charlottesville, VA, 3University of South Carolina, Columbia, SC Development Of IgE Against a Cimex Lectularius Allergen After Being Bitten By Bed Bugs Was Common Among Children In NYC Adnan Divjan1, Dr. Jason B. Price, MD2, Dr. Luis M. Acosta, MD1, Prof. Andrew Rundle, DrPH3, Prof. Inge Goldstein, DrPH4, Prof. Judith Jacobson, DrPH3, Prof. William R. Montfort, PhD5, Prof. Greg Freyer, PhD6 and Prof. Matthew S. Perzanowski, PhD1, 1Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, 2Division of Pediatrics, Department of Medicine, College of Physician & Surgeons, Columbia University, New York, NY, 3Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 4Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 5Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, 61Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York Divergent Effects Of Endotoxin and Mold Exposure On Asthma Exacerbations In The Childhood Asthma Management Program (CAMP) Dr. Ronina A. Covar, MD1, Mrs. Anna Forssen, MS1, Dr. Stanley J. Szefler, MD, FAAAAI2,3, David A. Schwartz, MD4 and Andrew H. Liu, MD1, 1National Jewish Health, Denver, CO, 2University of Colorado Denver School of Medicine, Denver, CO, 3Children’s Hospital Colorado, Denver, CO, 4University of Colorado Denver School of Medicine, Aurora, CO

SUNDAY

Abstracts AB331

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

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Inhibition Of Epidermal Tight Junction Function By Histamine Is Mediated By H1 and H4 Receptors Lisa A. Beck, MD, FAAAAI1, Takeshi Yoshida, PhD1, Sade Fridy1, I-Hsin Kuo, PhD1, Donald Y.M. Leung, MD, PhD, FAAAAI2 and Anna De Benedetto, MD, FAAAAI1, 1University of Rochester Medical Center, Rochester, NY, 2National Jewish Health, Denver, CO The Natural History and Clinical Predictors Of Egg Allergy In The First 2 Years Of Life: A Prospective, Population-Based, Cohort Study Ms. Rachel Peters, MPH1,2, Prof. Shyamali Dharmage, MD, PhD1,2, Prof. Lyle Gurrin, PhD2, Dr. Jennifer Koplin, PhD1, Prof. Anne-Louise Ponsonby, PhD1, Dr. Adrian Lowe, PhD2, Prof. Mimi L. K. Tang, MD, PhD, FAAAAI3, Dr. Dean Tey, MD1,4, Dr. David Hill, MBBD, FRACP1, Dr. Marnie Robinson, MBBD, FRACP5, Ms. Helen Czech, B.Nurs1, Ms. Leone Thiele, MNSc1, Dr. Nicholas Osborne, PhD6 and Prof. Katrina Jane Allen, MD, PhD, FAAAAI1,4, 1Murdoch Childrens Research Institute, Victoria, Australia, 2University of Melbourne, Victoria, Australia, 3The University of Melbourne, Melbourne, Australia, 4Royal Children’s Hospital, Victoria, Australia, 5Royal Children’s Hospital, Parkville, Australia, 6Royal Cornwall Hospital, Truro, United Kingdom Mendelian Inheritance Of Elevated Tryptase Associated With Atopy and Connective Tissue Abnormalities Dr. Jonathan J. Lyons, MD1, Dr. Guangping Sun, MD1, Dr. Kelly D. Stone, MD, PhD, FAAAAI1, Celeste Nelson, NP1, Laura Wisch, MSN1, Michelle O’Brien, RN, BSN1, Nina Jones, RN, BSN2, Dr. Andrew W. Lindsley, MD, PhD3, Dr. Hirsh D. Komarow, MD1, Yun Bai, MS1, Linda M. Scott, MS, CRNP1, Daly Cantave, MSN4, Dr. Irina Maric, MD5, Dr. J. Pablo Abonia, MD3, Dr. Marc E. Rothenberg, MD, PhD, FAAAAI3, Dr. Lawrence B.

121

AB332 Abstracts

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Schwartz, MD, PhD, FAAAAI6, Dr. Todd M. Wilson, DO1 and Dr. Joshua D. Milner, MD1, 1Laboratory of Allergic Diseases, NIAID/ NIH, Bethesda, MD, 2Frederick National Laboratory for Clinical Research, Frederick, MD, 3Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 4Clinical Center, National Institutes of Health, Bethesda, MD, 5Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD, 6Virginia Commonwealth University, Richmond, VA Expression Of TSLP and TSLP-R In Chronic Idiopathic Urticaria Ms. Patricia M. Sterba, MS1, Allen Myers, Ph.D2 and Dr. Sarbjit S. Saini, MD, FAAAAI1, 1Johns Hopkins University, Baltimore, MD, 2Division of Allergy & Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD Preclinical Study Of Rapidly-Disintegrating Sublingual Tablets (RDST): Effect Of Epinephrine (E) Incorporated As NanoCrystals Dr. Keith Simons, PhD1, Dr. Ousama Rachid, PhD1, Dr. Mutasem Rawas-Qalaji, PhD2, Dr. Belacryst Mendez, PhD3, Ms. Annette Losada3 and Dr. F. Estelle R. Simons, MD, FAAAAI1, 1University of Manitoba, Winnipeg, MB, Canada, 2Nova Southeastern University, F. Lauderdale, FL, 3Nova Southeastern University, Ft. Lauderdale, FL

Chronic Rhinosinusitis and Polyps 3806 Sunday, March 2nd, 2014, 4:00 PM - 6:00 PM 581

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A 24-Month Randomized, Controlled Trial Of An Automated Speech Recognition Program To Improve Adherence In Pediatric Asthma Bruce G. Bender, PhD FAAAAI1, Peter Cvietusa2, Glenn Goodrich2, C. Ryan Lowe2, Heather Nuanes2, Susan Shetterly2, Cathy R. Tacinas2, Nicole Wagner2, Frederick S. Wamboldt1, Stan Xu2 and David Magid2, 1National Jewish Health, Denver, CO, 2Kaiser Permanente Colorado, Denver, CO Asthma Carepartners: A Home-Based Asthma Intervention Embedded Within Medicaid Managed Care Ms. Julie Kuhn, MSW1, Ms. Helen Margellos-Anast, MPH1, Ms. Tala Alhajj Schwindt, MPH1, Ms. Lourdes Reyes2, Ms. Barbara Hay, M.A.2, Ms. Sheena Freeman, B.A.1 and Ms. Gloria Seals1, 1Sinai Urban Health Institute, Chicago, IL, 2Family Health Network, Chicago, IL The Osia Platform: An Extensible Tool For Improving Individual Allergy and Asthma Control and Understanding Environmental Drivers Dr. Richard W Lucas, PhD1, Mr. Josh Dees2, Mr. Rob Reynolds2, Mr. Bryn Rhodes3 and Dr. Richard W Hendershot, MD4, 1Swedish University of Agricultural Sciences, Umea, Sweden, 2OSIA Medical, Sandy, UT, 3Database Consulting Group, Orem, UT, 4Intermountain Health Care, Salt Lake City, UT Allergy Immunotherapy Significantly Reduces Outpatient Services Use For Allergy and Respiratory Conditions In Patients With Newly-Diagnosed Allergic Rhinitis Dr. Cheryl S. Hankin, PhD1, Dr. Linda Cox, MD, FAAAAI2, Dr. Amy Bronstone, PhD1 and Ms. Zhaohui Wang, M.S.1, 1BioMedEcon, LLC, Moss Beach, CA, 2Allergy & Asthma Center, Fort Lauderdale, FL Real-Time Asthma Outreach Reduces Excessive Short-Acting Beta-Agonist (SABA) Canister-Dispensing: A Randomized Study Dr. Robert S. Zeiger, MD, PhD, FAAAAI1, Dr. Michael Schatz, MD, MS, FAAAAI1, Qiaowu Li, M.S.2, Dr. James Zazzali, PhD3 and Wansu Chen, M.S.2, 1Kaiser Permanente Southern California, San Diego, CA, 2Kaiser Permanente Southern California, Pasadena, CA, 3Genentech, Inc., South San Francisco, CA

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Activation Of TLR4 Induces VEGF Expression Via Akt Pathway In Nasal Polyps Mrs. Jung-Sun Cho1, Mr. Ju-Hyung Kang1, Ms. In-Hye Han1, Mrs. Ji-Young Um1, Prof. Il-Ho Park2 and Prof. Heung-Man Lee2,3, 1Department of Biomedical Sciences, Korea University Graduate School, Seoul, South Korea, 2Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, South Korea, 3Medical Devices Clinical Trial Center, Guro Hospital, Korea University, Seoul, South Korea Non-Eosinophilic Nasal Polyps In Second-Generation Asian Patients In The U.S. With Chronic Rhinosinusitis; Evidence For Genetic Influence On Eosinophilia Dr. Mahboobeh Mahdavinia, MD, PhD1, Ms. Lydia Suh, BSc2, Mr. James Norton, MS2, Mr. Roderick Carter, BSc2, Dr. Atsushi Kato, PhD2, Dr. Anju T. Peters, MD, FAAAAI2, Dr. Rakesh Chandra, MD3, Dr. Bruce K. Tan, MD4, Dr. David Conley, MD4, Dr. Robert C. Kern, MD4, Dr. Leslie C. Grammer, MD, FAAAAI2 and Dr. Robert P. Schleimer, PhD FAAAAI5, 1Department of Medicine, Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, chicago, IL, 2 Department of Medicine, Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Northwestern University, Chicago, IL, 4Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, 5Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL Regulation Of Expression Of Pendrin Protein In CRS With Nasal Polyps and In Airway Epithelial Cells Dr. Sudarshan Seshadri, PhD1, Dr. Xiang Lu, MD, PhD1, Mr. Matthew Purkey, BS1, Dr. Tetsuya Homma, MD1, Mr. Andrew Choi1, Mr. Roderick Carter, BSc1, Mr. James Norton, MS1, Ms. Lydia Suh, BSc1, Dr. Atsushi Kato, PhD1, Prof. Pedro C. Avila, MD, FAAAAI1, Dr. Anju T. Peters, MD, FAAAAI1, Dr. David Conley, MD2, Dr. Rakesh Chandra, MD3, Dr. Bruce K. Tan, MD2, Dr. Leslie C. Grammer, MD, FAAAAI1, Dr. Robert C. Kern, MD2 and Dr. Robert P. Schleimer, PhD FAAAAI4, 1Department of Medicine, Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Northwestern University, Chicago, IL, 4Division of AllergyImmunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL Sex-Specific Differences In Disease Severity In Patients With Chronic Rhinosinusitis With Nasal Polyps Dr. Kathryn E. Hulse, PhD1, Dr. Whitney Wyatt Stevens, MD, PhD2, Dr. Bruce K. Tan, MD3, Mr. James Norton, MS2, Ms. Lydia Suh, BSc2, Dr. Robert C. Kern, MD3, Dr. David Conley, MD3, Dr. Rakesh Chandra, MD1, Dr. Anju T. Peters, MD, FAAAAI2, Dr. Leslie C. Grammer, MD, FAAAAI2, Ms. Kathleen E. Harris, BSc2, Mr. Roderick Carter, BSc2, Dr. Atsushi Kato, PhD2, Dr. Margrit Urbanek, PhD4 and Dr. Robert P. Schleimer, PhD FAAAAI5, 1Northwestern University, Chicago, IL, 2Department of Medicine, Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3 Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, 43Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, 5Division of AllergyImmunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL

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The Role Of Innate Cytokine In Non-Asthmatic, Non-Eosinophilic Nasal Polyps: IL-25, IL-33 and TSLP Dr. Dong-Kyu Kim1, Dr. Hyun-Woo Shin2, Dr. Jong-Wan Park2, Dr. Min-Suk Yang3 and Dr. Dae Woo Kim3, 1Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, South Korea, 2Seoul National University College of Medicine, Pharmacology and Biomedical Science, Ischemic/Hypoxic Disease Institute, South Korea, 3Seoul National University Hospital and Boramae Medical Center, South Korea

The Redwan Moqbel Memorial MAAI Featured Poster Session

Johns Hopkins University School of Medicine, Baltimore, MD, Johns Hopkins University School of Medicine, 3Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, 4Geisinger Community Medical Center., Scranton, PA, 5Johns Hopkins University Medical Center, Baltimore, MD 2

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IL33 and Type 2 Innate Lymphoid Cells (ILC2) But Not Th2 Cells Are Essential For Persistence Of Chronic Experimental Asthma Dr. Christina Christianson, PhD, Ms. Chaoyu Irvin, MS, Magdalena Gorska, MD, PhD and Rafeul Alam, MD, PhD, FAAAAI, National Jewish Health, Denver, CO PGE2 Deficiency Causes a Phenotype Of Aspirin Sensitive Asthma That Depends On Platelets and Cysteinyl Leukotrienes Dr. Tao Liu, PhD1,2, Dr. Joshua A. Boyce, MD, FAAAAI1,2, Dr. Tanya M. Laidlaw, MD, FAAAAI1,2 and Dr. Howard Katz, PhD1,2, 1Brigham and Women’s Hospital, Division of Rheumatology, Immunology and Allergy, Boston, MA, 2Harvard Medical School, Boston, MA CCR8 Is a Receptor For CCL18 On Human Th2 Cells Dr. Morris Ling, MD1, Dr. Sabina Islam, MD1,2, Dr. John Leung, MD3, Wayne G. Shreffler, MD, PhD, FAAAAI1,2 and Dr. Andrew D. Luster, MD, PhD4,5, 1Massachusetts General Hospital, Boston, MA, 2Harvard Medical School, Boston, MA, 3Tufts Medical Center, Boston, MA, 4Massachusetts General Hospital, Charlestown, MA, 5Harvard Medical School, Charlestown, MA Increased Frequency Of Dual Positive Th2/Th17 Cells In Bronchoalveolar Lavage Characterizes a Population Of Severe Asthmatic Patients Rafeul Alam, MD, PhD, FAAAAI, Ms. Chaoyu Irvin, MS, Dr. James Good, MD, Dr. Donald Rollins, MD, Dr. Christina Christianson, PhD, Ms. Iram Zafar, MS, Magdalena Gorska, MD, PhD and Dr. Richard J. Martin, MD, National Jewish Health, Denver, CO Cmrf-35-Like Molecule 1 (CLM-1) Is Required For IL-4-Induced Cellular Responses and Development Of Allergic Airway Inflammation Mr. Itay Moshkovits1, Mrs. Danielle Karo-Atar1, Mrs. Dana Shik1, Dr. Alon Hershko, MD, PhD2 and Dr. Ariel Munitz, PhD1, 1Department of Clinical Microbiology and Immunology, The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel, 2Laboratory of Allergy and Clinical Immunology, Department of Medicine,The Herbert Center of Mast Cell Disorders, Meir Medical Center, Kfar Saba, Israel

Allied Health Featured Poster 3811 Sunday, March 2nd, 2014, 4:00 PM - 6:00 PM 591

Quality Of Life Improves In Children Undergoing Peanut Immunotherapy Ms. Shannon Seopaul, BS1, Dr. Satya Narisety, MD2, Corinne Keet, MD, MS3, Ms. Kim E. Mudd, RN MSN CCRP1, Ms. Sarah D. Knorr, RN MPH CCRP4 and Robert A. Wood, MD, FAAAAI5,

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Asthma In The Elderly: The Role Of Vitamin D Dr. Michele Columbo, MD, FAAAAI, Asthma, Allergy and Immunology Specialists, Bryn Mawr, PA, Dr. Reynold A. Panettieri Jr., MD, University of Pennsylvania, Philadelphia, PA and Dr. Albert S. Rohr, MD, FAAAAI, Rohr and Columbo Asthma, Allergy and Immunology Specialists, Bryn Mawr, PA A Preliminary Randomized Controlled Trial:Educational Intervention For Treatment Of Hispanic and African American Adults With Asthma: Allergen Triggers, Peak Flow, and Spirometry Reenal Patel, MD, UMDNJ, Newark, NJ, Josha Fogel, PhD, Nassau University Medical Center, East Meadow, NY and Marianne Frieri, MD, PhD, FAAAAI, State University of NY @ Stony brook, Stony Brook, NY Assessment Of Asthma Education and Teaching Practices Among Allergists Natalia Vernon, M.D., Penn State Hershey Medical Center, Hershey, PA and Dr. Timothy Craig, D.O., Penn State University, Hershey, PA Comparison Of Asthma-Related ED Visits In Public Versus Private Hospitals In The Bronx Dr. Mili Shum, MD, Weill Cornell Medical College, New York, NY; Montefiore Medical Center, Bronx, NY, Dr. David L. Rosenstreich, MD, FAAAAI, Albert Einstein/Montefiore Medical Center, Bronx, NY and Dr. Sunit Jariwala, MD, Albert Einstein/ Montefiore Medical Center, New York, NY Comparison Of Pre- and Post-Pubertal Gender Differences In Markers Of Angiogenesis and Asthma Outcomes Dr. Amy Thomas, MD1, Mark DeVries2, Mr. Christopher J. Tisler, MT2, Ms. Victoria Rajamanickam3, Dr. James E. Gern, MD, FAAAAI2, Dr. Robert F. Lemanske Jr., MD, FAAAAI2 and Dr. Daniel J. Jackson, MD4, 1University of Wisconsin Hospitals and Clinics, Madison, WI, 2University of Wisconsin School of Medicine and Public Health, Madison, WI, 3University of Wisconsin Hospitals and Clinics, 4Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI Asthma Exacerbation In U.S. Adults: Who Are The Frequent Utilizers Of The Emergency Department? Dr. Kohei Hasegawa, MD, MPH1,2, Ashley Sullivan, MPH, MS1, Stuart Turner, BPharm, MPH3, Susan Massaro, PharmD, MPH4 and Dr. Carlos Camargo Jr., MD, DrPH1,2, 1Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, 2Harvard Medical School, Boston, MA, 3Novartis Pharmaceuticals Corporation, East Hanover, NJ, 4Novartis Pharmaceuticals The Relationship Of The Serum Vitamin D Levels With Asthmatic Severity Responses In Asthmatic Children Dr. Julio Orellana1, Dr. Telma Varela2, Dr. Ana Romero Boni1, Dr. on Ofelia Mi~ no1, Dr. Estela Pautasso1, Dr. Susana Rivolta1, Dr. Ram! Pogonza3 and Dr. Juan Carlos Muino, MD, PhD, FAAAAI4, 1Nuevo Hospital de Ni~ nos de la Santisima Trinidad Cordoba Argentina, nos de la Santisima TriCordoba, Argentina, 2Nuevo Hospital de Ni~ nidad Cordoba Argentina, C! ordoba, Argentina, 3Nuevo Hospital de Ni~ nos de la Santisima Trinidad Cordoba Argentina - CIU, Cordoba, Argentina, 4FAC CS MED UNC, Cordoba, Argentina

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Newly Diagnosed Asthma In The Elderly: Is It Really Different? Prof. Bilun Gemicioglu, MD, PhD, Istanbul Univ. Cerrahpasa Faculty of Medicine, Istanbul, Turkey, Prof. Oznur Abadoglu, MD, Cumhuriyet Univ. Faculty of Medicine, Sivas, Turkey, Dr. Levent Akyildiz, MD, Mardin Medical Park Hospital, Mardin, Turkey, Prof. Hasan Bayram, MD, PhD, University of Gaziantep, Gaziantep, Turkey, Prof. Aykut Cilli, MD, Akdeniz Univ. Faculty of Medicine, Antalya, Turkey, Prof. Arif Cimrin, MD, Dokuz Eylul Univ. Faculty of Medicine, Izmir, Turkey, Prof. Hakan Gunen, MD, Sureyyapasa Pulmonary Diseases Hospital and Research Center, Istanbul, Turkey, Prof. Zeynep Misirligil, MD, Ankara Univ. Faculty of Medicine, Ankara, Turkey, Prof. Tevfik Ozlu, MD, Karadeniz Teknik Univ. Faculty of Medicine, Trabzon, Turkey, Prof. Mecit Suerdem, MD, Selcuk Univ. Faculty of Medicine, Konya, Turkey and Prof. Esra Uzaslan, MD, Bursa Univ. Faculty of Medicine, Bursa, Turkey Risk Factors For Acute Asthma In The City Of Esmeraldas, Ecuador Dr. Cristina Ardura-Garcia1, Gisela Oviedo2, Maritza Vaca2, Carlos Sandoval2, Stefanie Menzies2, Lisa J. Workman, BA3, Prof. Matthew S. Perzanowski, PhD4, Maria Jose Rosa5, Thomas A.E. Platts-Mills, MD, PhD, FAAAAI3 and Dr. Phil J. Cooper2,6, 1University of Liverpool, Wellcome Trust PhD Fellow, Liverpool, United Kingdom, 2Laboratorio de FEPIS, Quinind!e, Esmeraldas Province, Ecuador, 3Division of Asthma, Allergy & Immunology, University of Virginia Health System, Charlottesville, VA, 4Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, 5Columbia University, New York, NY, 6St. George’s University, London, United Kingdom Serum Vitamin D Levels and Clinical Features Of The Disease In Children With Asthma Aged 5 –To 18 Years Old Dr. Zeynep Tamay, MD, Associate Professor of Pediatrics, Istanbul University, Istanbul School of Medicine, Department of Pediatrics, Division of Pediatric Allergy, Istanbul, Turkey, Dr. Nurhan Ozcan, Ege Medical Faculty, Department of Pediatrics, Prof. Firdevs Bas, Istanbul University, Istanbul School of Medicine, Department of Pediatrics; Division of Pediatric Endocrinology, Prof. Umit Turkoglu, Istanbul University, Istanbul School of Medicine, Department of Pediatrics, Division of Biochemistry and Prof. Nermin Guler, MD, Istanbul University, Istanbul School of Medicine, Department of Pediatrics, Division of Pediatric Allergy, Turkey Effectiveness Of Specific Immunotherapy Against Alternaria Alternata In Patients With Asthma and Or Allergic Rhinitis Dr. Silvia Mart!ınez Blanco, MD1, Dr. Ana Ant!on-Laiseca, MD1, Dr. R. Mielgo Ballesteros, MD1, Dr. Consuelo Fern!andez Rodr!ıguez, MD, PhD1, Dr. Ruth Barranco Jim!enez, MD1 and Dr. R. Vives Conesa, MD2, 1Hospital Universitario 12 de Octubre, Spain, 2Hospital Universitario 12 de Octubre, Madrid, Spain Vitamin D Levels As Related To Severity and Ethnicity In Asthmatics Dr. Patricia H. Stewart, MD1, Dr. Thomas Pressley, PharmD1, Dr. Deborah Minor, PharmD1 and Prof. Gailen D. Marshall Jr., MD, PhD, FAAAAI2, 1University of Mississippi Medical Center, 2University of Mississippi Medical Center, Jackson, MS Real Life Study Of Safety and Efficacy Of Subcutaneous Immunotherapy With Cat and Dog Extracts Ms. Silvia Uriarte and Prof. Joaquin Sastre, MD, PhD, FAAAAI, Fundaci! on Jim!enez D!ıaz, Madrid, Spain Improvement In Quality Of Life In Parents Of Asthmatic Children Aged < 4 Years Receiving Subcutaneous Allergy Immunotherapy Yurydia Jorge1, Yikania Pichardo1, Paola Polanco, MD2, Xin Zheng, PhD3, Jose Adames, BS3, Dr. Andrew A. Wiznia, MD3, Dr. David L. Rosenstreich, MD, FAAAAI4 and Dr. Gabriele De Vos, MD5, 1Jacobi Medical Center, New York, NY, 2Jacobi Medical Center, 3Albert Einstein College of Medicine, 4Albert Einstein/

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Montefiore Medical Center, Bronx, NY, 5Albert Einstein College of Medicine, Bronx, NY Ashmi Suppresses Neutrophil Pulmonary Inflammation In a Ragweed Allergic Asthma Model That Is Associated With Modulation Of Innate and Adaptive Immune Responses Dr. Kamal D. Srivastava, PhD1, Dr. David Dunkin, MD2, Dr. Nan Yang, PhD, MS1, Dr. Changda Liu, PhD1, Dr. Rachel L. Miller, MD, FAAAAI3 and Dr. Xiu-Min Li, MD1, 1Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 2Icahn School of Medicine at Mount Sinai, New York, NY, 3Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, New York, NY Longitudinal Characteristics Of Viral and Non-Viral Exacerbations Of Childhood Asthma Dr. Amaziah Coleman, MD1, Dr. Daniel J. Jackson, MD2, Dr. Ronald E. Gangnon, PhD1, Mr. Michael D. Evans, MS1, Dr. Robert F. Lemanske Jr., MD, FAAAAI1 and Dr. James E. Gern, MD, FAAAAI1, 1University of Wisconsin School of Medicine and Public Health, Madison, WI, 2Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI

Biomarkers and Asthma Control II 4202 Monday, March 3rd, 2014, 9:45 AM - 10:45 AM 608

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Bronchial Epithelial Cell Gene Expression In Relation To Exhaled Nitric Oxide Identifies New Molecular Asthma Phenotypes Dr. Brian D. Modena, MD1, Dr. John Tedrow, MD1, Dr. Jadranka Milosevic, PhD1, Dr. Naftali Kaminski, MD2 and Sally E. Wenzel, MD, FAAAAI1, 1University of Pittsburgh Medical Center NW, Pittsburgh, PA, 2Yale-New Haven Hospital, New Haven, CT How Common Is The Phenotype Reflected By ‘‘The Atopic March’’? Results At Two Years Of Age In a General Risk Multi-Racial Birth Cohort Dr. Christine Cole Johnson, PhD MPH FAAAAI1, Ms. Suzanne Havstad, M.A.1, Dr. Dennis Ownby, M.D. FAAAAI2, Dr. Christine L.M. Joseph, PhD1, Dr. Haejin Kim, MD3, Kimberley J. Woodcroft, PhD1, Dr. Edward M. Zoratti, MD, FAAAAI4 and Ganesa Wegienka, PhD1, 1Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, 2Department of Pediatrics Georgia Regents University, Augusta, GA, 3Division of Allergy and Clinical Immunology, Henry Ford Hospital, Detroit, MI, 4Henry Ford Health System, Detroit, MI Is Asthma Predictive Index Feasible For A Retrospective Study? Dr. Chung I. Wi, MD1, Dr. Miguel A. Park, MD2 and Dr. Young J. Juhn, MD, MPH1, 1Dept of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, 2Department of Internal Medicine: Division of Allergic Diseases, Mayo Clinic, Rochester, MN Comparison Of Rates Of Prescribing Oral Corticosteroids For Asthma Exacerbations Between Step-Down Therapy Approaches Among Initiators Of Inhaled Corticosteroids and Long-Acting Beta-Agonist Combination Therapy Ayad K. Ali, PhD1,2, Almut Winterstein, PhD2, Leslie Hendeles, PharmD2, Xiaomin Lu, PhD3, Richard Segal, PhD2 and Abraham Hartzema, PhD2, 1Eli Lilly and Company, Indianapolis, IN, 2College of Pharmacy, University of Florida, Gainesville, FL, 3College of Public Health and Health Professions, College of Medicine, University of Florida, Gainesville, FL The Good, The Bad and The Ugly Of The Naepp EPR3 Guidelines Dr. Priyanka Lall, MD, Emory University, Atlanta, Dr. Karen A. DeMuth, MD, FAAAAI, Emory University, Atlanta, GA and Dr. Morton Galina, Emory University

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Fibrin Complexes From The Sputum Of Human Asthmatics Contain Viable Fungi Dr. Rani Maskatia, MD1, Cameron Landers, B.S1, Dr. Evan Li, M.D.1, Dr. Roger Rossen, M.D.1,2, Dr. Frank M. Orson, MD, FAAAAI1,2 and Dr. David B. Corry, MD1, 1Baylor College of Medicine, Houston, TX, 2Veterans Affairs Medical Center, Houston, TX Proteomic Identification Of S100A8 As a Potential Effector Protein Of Acupuncture In Asthma Treatment Yu-Dong Xu1,2, Yu Wang1, Ying Wei1, Lei-Miao Yin1, Jun Ran1 and Yong-Qing Yang1,2, 1Molecular Biology Laboratory, Shanghai Research Institute of Acupuncture and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai, China, 2Yue Yang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China Are Asthma Specialists and Non-Specialists Familiar With Inhaled Corticosteroid (ICS) Dosing Recommendations and Side Effects In Children With Asthma? Dr. Jonathan Drori, West Penn Allegheny Health System, Pittsburgh, PA Medication Remaining In Discarded Metered Dose Inhalers Of Asthmatic Children Dr. Wantida Dampanrat, MD, Prince Of Songkla University, Hatyai, Thailand, Dr. Pasuree Sangsupawanich, MD, Prince Songkhlanagarind hospital, Hadyai, Thailand and Dr. Araya Yuenyongviwat, MD, Prince of Songkla University, Songkhla, Thailand Defining Severe Asthma In Childhood: A Descriptive Multicenter Study In Turkey Bulent Enis Sekerel1, Dr. Ozge Soyer2, Fatih Celmeli3, Yakup Canitez3, Ozlem Keskin3, Demet Can3, Ferhat Catal3, Mehtap Kilic3, Burcin Nalbantoglu3, Nail Yologlu3, Suleyman T. Yavuz3, Belgin Guc3, Fadil Ozturk3, Gulbin Karakoc3, Suna Asilsoy3, Mehmet Kilic3, Cem Razi3, Dost Zeyrek3, Semanur Kuyucu3, Hasan Yuksel3, Omer Cevit3, Aysen Bingol3, Mehtap G. Yazicioglu3 and Ayse Yenigun3, 1Hacettepe University, Pediatric Allergy Unit, Ankara, Turkey, 2Hacettepe University School of Medicine, Ankara, Turkey, 3TURPEDAS, Turkey The Pediatric Diagnostic Conundrum Of Chronic Respiratory Symptoms Zainab Kagen, MD, University of Tennesee College of MedicineChattanooga, TN, Joel Ledbetter, MD, University of Tennessee College of Medicine-Chattanooga, TN, Jennifer Hamm, MD, University of Tennesee College of Medicine-Chattanooga and Esther Wilson, MD, University of Tennessee College of Medicine-Chattanooga

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IVIG and Other Therapeutics 4203 Monday, March 3rd, 2014, 9:45 AM - 10:45 AM 619

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Quantification Of The Wear-Off Effect Towards The End Of The Intravenous Immunoglobulin Infusion Interval: Pooled Data Analysis Mr. John-Philip Lawo, CSL Behring GmbH, Marburg, Germany, Dr. Alphonse Hubsch, CSL Behring AG, Berne, Switzerland and Dr. Mikhail Rojavin, PhD, Clinical Research and Development, CSL Behring LLC, King of Prussia, PA Safety and Efficacy Of Biweekly Hizentra Administration In Patients With Primary Immunodeficiency Diseases: A Retrospective Single-Center Study Clare Malcolmson and Dr. Alison Jones, Great Ormond Street Hospital, London, United Kingdom Long-Term Tolerability and Safety Of Facilitated-Subcutaneous Infusion Of Human Immune Globulin G (IgG), 10%, and Recombinant Human Hyaluronidase (rHuPH20) (IGHy): A Phase 3 Extension Study In Patients With Primary Immunodeficiencies (PIs)

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Dr. Isaac Reuven Melamed, MD1, Dr. Richard L. Wasserman, MD, PhD, FAAAAI2, Dr. Mark Stein, MD, FAAAAI3, Dr. Arye Rubinstein, MD, FAAAAI4, Dr. Jennifer M. Puck, MD5, Sudhir Gupta, MD, PhD, FAAAAI6, Werner Engl7, Dr. Heinz Leibl, PhD7, Dr. Leman Yel, MD, FAAAAI8 and Dr. Richard I. Schiff, MD, PhD8, 1IMMUNOe Health Centers, Centennial, CO, 2DallasAllergyImmunology, Dallas, TX, 3 Allergy Associates of the Palm Beaches, North Palm Beach, FL, 4Albert Einstein College of Medicine, Bronx, NY, 5Department of Pediatrics, University of California San Francisco and UCSF Benioff Children’s Hospital, San Francisco, CA, 6University of California, Irvine, Irvine, CA, 7Baxter BioScience, Vienna, Austria, 8Baxter BioScience, Westlake Village, CA Health-Related Quality Of Life Of Japanese Patients With Primary Immunodeficiency Diseases Receiving IgPro20, a 20% Liquid Subcutaneous Immunoglobulin (Hizentra) Prof. Hirokazu Kanegane, MD, PhD1, Prof. Kohsuke Imai, MD, PhD2, Prof. Masafumi Yamada, MD, PhD3, Prof. Hidetoshi Takada, MD, PhD4, Prof. Tadashi Ariga, MD, PhD3, Prof. Ataru Igarashi, PhD5, Prof. Kiichiro Tsutani, MD, PhD5, Dr. Martin Bexon, MD6, Dr. Mikhail Rojavin, PhD7, Ms. Midori Kobayashi, BSPharm, MBA8, Dr. John-Philip Lawo, PhD9, Mr. Art Zbrozek, RPh, MSc, MBA10, Prof. Shigeaki Nonoyama, MD, PhD11, Prof. Toshiro Hara, MD, PhD4 and Prof. Toshio Miyawaki, MD, PhD1, 1Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan, 2Department of Community Pediatrics, Perinatal and Maternal Medicine, Tokyo Medical and Dental University, Tokyo, Japan, 3Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 4Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 5Department of Drug Policy and Management, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan, 6Clinical Research and Development, CSL Behring AG, Berne, Switzerland, 7Clinical Research and Development, CSL Behring LLC, King of Prussia, PA, 8Research and Development, CSL Behring K.K., Tokyo, Japan, 9 CSL Behring GmbH, Marburg, Germany, 10CSL Behring LLC, King of Prussia, PA, 11Department of Pediatrics, National Defense Medical College, Tokorozawa, Japan Efficacy and Tolerability Of Privigen In Clinical Practice Dr. Morna J. Dorsey, MD MMSc FAAAAI1, Viet Ho2, Dr. Mohsen I. Mabudian, MD3, Pere Soler-Palacın4, Nerea Domınguez-Pinilla5, Dr. Robert W. Hellmers, MD, FAAAAI6, Dr. Radha Gandhi Rishi, MD, FAAAAI6, Rahul Rishi7, Dr. Duane W. Wong, MD6, Dr. Mikhail Rojavin, PhD8, Dr. Alphonse Hubsch9 and Dr. Melvin Berger, MD, PhD, FAAAAI8, 1Department of Pediatrics, University of California, San Francisco, San Francisco, CA, 2Moffitt Cancer Hospital, FL, 3Beaver Medical Group, Inc., Department of Allergy and Clinical Immunology, Redlands, CA, 44Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d’Hebron, Barcelona, Spain, 55Department of Pediatrics, Hospital 12 de Octubre, Madrid, Spain, 6Arizona Allergy Associates, Chandler, AZ, 7Arizona Allergy Associates, Phoenix, AZ, 8 Clinical Research and Development, CSL Behring LLC, King of Prussia, PA, 9CSL Behring AG, Berne, Switzerland Safety and Tolerability Of An Intravenously Administered Alpha1-Proteinase Inhibitor (A1PI) At An Increased Infusion Rate: A Randomized, Rate Control, Placebo-Masked, Crossover Study In Healthy Adults Adam Haeberle1, Leock Ngo1, Neil Inhaber1, David Gelmont1 and Dr. Leman Yel, MD, FAAAAI2, 1Baxter BioScience, 2Baxter BioScience, Westlake Village, CA Pharmacokinetic Modeling Predicts Different IgG Exposures Using Different IVIG-Scig Dose Conversion Factors In Patients With Primary Immune Deficiency Dr. Jagdev S. Sidhu, PhD1, Dr. Mikhail Rojavin, PhD2, Dr. Melvin Berger, MD, PhD, FAAAAI2, Dr. Martin Bexton3 and Dr. Jonathan M. Edelman, MD2, 1Clinical Pharmacology & Early Development,

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CSL Ltd, Parkville, Australia, 2Clinical Research and Development, CSL Behring LLC, King of Prussia, PA, 3CSL Behring AG, Berne, Switzerland Flexible Dosing For Hizentra: Pharmacokinetic Simulations Of Various Subcutaneous Dosing Regimens and Compliance In Patients With Primary Immunodeficiency Dr. Mikhail Rojavin, PhD1, Dr. Jagdev S. Sidhu, PhD2, Dr. Martin Bexon, MD3 and Dr. Jonathan M. Edelman, MD1, 1Clinical Research and Development, CSL Behring LLC, King of Prussia, PA, 2Clinical Pharmacology & Early Development, CSL Ltd, Parkville, Australia, 3Clinical Research and Development, CSL Behring AG, Berne, Switzerland Effect Of Synthetic Steroids and Hydroxychloroquine On BCell IgE Production Dr. Ahila Subramanian, MD, MPH, Yingchun Han and Dr. Fred H. Hsieh, MD, Cleveland Clinic Foundation, Cleveland, OH Safety, Tolerability, and Efficacy Of Hizentra In Japanese Patients With Primary Immunodeficiency Over 48 Weeks Prof. Kohsuke Imai, MD, PhD1, Prof. Hirokazu Kanegane, MD, PhD2, Prof. Masafumi Yamada, MD, PhD3, Prof. Hidetoshi Takada, MD, PhD4, Prof. Tadashi Ariga, MD, PhD3, Ms. Midori Kobayashi, BSPharm, MBA5, Dr. Mikhail Rojavin, PhD6, Dr. Martin Bexon, MD7, Prof. Shigeaki Nonoyama, MD, PhD8, Prof. Toshiro Hara, MD, PhD4 and Prof. Toshio Miyawaki, MD, PhD2, 1Department of Community Pediatrics, Perinatal and Maternal Medicine, Tokyo Medical and Dental University, Tokyo, Japan, 2Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan, 3Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 4Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 5Research and Development, CSL Behring K.K., Tokyo, Japan, 6Clinical Research and Development, CSL Behring LLC, King of Prussia, PA, 7Clinical Research and Development, CSL Behring AG, Berne, Switzerland, 8Department of Pediatrics, National Defense Medical College, Tokorozawa, Japan In Vitro Effect Of Intravenous Immunoglobulin (IVIG) On Natural Antibody Producing Human B1 Cells Kevin A. Cook, MD1, Sudhanshu Agrawal, MS1 and Sudhir Gupta, MD, PhD, FAAAAI2, 1University of California, Irvine, 2University of California, Irvine, Irvine, CA Effect Of A Novel, Oral Histamine H4R Antagonist On Histamine-Induced Pruritus In Healthy Subjects Dr. Alexa P. Kollmeier, MD1, Paul Dunford, MSc1, Xie Xu, PhD1, Andrew Greenspan, MD1, Yichuan Xia, PhD2, Bei Zhou, PhD2, Klaus Francke, MD, PhD3 and Dr. Robin L. Thurmond, PhD1, 1 Janssen Research & Development, LLC, La Jolla, CA, 2Janssen Research & Development, LLC, Spring House, PA, 3Parexel International, London, United Kingdom Decreasing Risk Of Infection and Severity Of Infections Resulting In Hospitalizations In Patients With Primary Immunodeficiency Disease Changing From IVIG To Scig Therapy Mr. Art Zbrozek, RPh, MSc, MBA1, Ms. Sonam Mehta2, Dr. Dipen A. Patel2 and Mr. Marc Botteman, MSc2, 1CSL Behring LLC, King of Prussia, PA, 2Pharmerit International, Bethesda, MD A Multicenter Non-Interventional Study On The Efficacy and Tolerability Of The Polyvalent Intravenous Immunoglobulin Privigen Dr. Rainer Hoffmann, MD1, Dr. Peer Lotichius, PhD2 and Dr. Dietmar Pfruender, MD2, 11Praxis f€ ur Neurologie und Psychiatrie, Berlin, Germany, 2CSL Behring, Hattersheim, Germany The Immunoglobulin Diagnosis, Evaluation, and Key Learnings (IDEaL) Patient Registry: Analysis Of Ig Dosing, Infection Control, and Quality-Of-Life Assessments In Our Primary Immunodeficiency Population Sean Kearns, Ph.D1, Keith Crawford1, Loretta Kristofek, RN1, Robbyn Kirylo1 and Dr. Luqman Seidu, MD2, 1Coram Clinical Trials, Denver, CO, 2Allergy and Asthma of Atlanta, LLC, Atlanta, GA

J ALLERGY CLIN IMMUNOL FEBRUARY 2014

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Retrospective Analysis Of The Clinical Utility Of Biweekly Dosing With High-Concentration Subcutaneous Immunoglobulin In 10 Patients With Primary Immunodeficiency Dr. Richard L. Wasserman, MD, PhD, FAAAAI1, Dr. Shahnaz Fatteh2, Dr. Javaid M. Khan, DO2 and Dr. Elie Haddad, MD3, 1 Medical City Children’s Hospital, Dallas, TX, 2Larkin Community Hospital, South Miami, FL, 3CHU Sainte-Justine, Montreal, QC, Canada

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Concomitant FMF and TRAPS Mutation In a Periodic Fever Patient Dr. Adrianne C. Netterville, MD1, Dr. Victoria Dimitriades, MD1 and Dr. Paul D. Niolet, MD2, 1Louisiana State University Department of Pediatrics, New Orleans, LA, 2Allergy Asthma and Immunology, Ocean Springs, MS Association Of Interleukin-23 Receptor Single Nucleotide Polymorphisms With Ulcerative Colitis Dr. Mona Hedayat, MD, Boston Children’s Hospital, Boston, MA, Dr. Nasser Ebrahimi Daryani, Department of Gastroenterology and Hepatology, Tehran University of Medical Sciences, Dr. Farnaz Najmi Varzaneh, Molecular Immunology Research Center, Department of Immunology, Tehran University of Medical Sciences and Dr. Nima Rezaei, MD, PhD, Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Tehran, Iran A Novel Immunoablative Regimen Utilized In The Successful Remission Of Pulmonary Hemorrhage In An Adolescent Female With Systemic Lupus Erythematosus Ms. Vivian E. Cino, MSN ARNP-BC PNP1, Alexander Constantinescu, MD2, Kristina Deeter, MD2, Faina Shenderov, PharmD2, Joan Spiro, PharmD2 and Dr. Gary I. Kleiner, MD, PhD, FAAAAI2, 1 Joe Dimaggio Children’s Hospital, Hollywood, FL, 2Joe Dimaggio Children’s Hospital Haptoglobin Deficiency and Autoimmune Manifestations; A Case Series Dr. Anna Kochin, MD1, Dr. Jenny Shliozberg, MD, FAAAAI1 and Dr. Arye Rubinstein, MD, FAAAAI2, 1Montefiore Medical Center, Bronx, NY, 2Albert Einstein College of Medicine, Bronx, NY Immunogenicity Analysis Of Two Anti-TNF (Infliximab vs Etanercept) Therapies In Rheumatologic Patients Dr. Yvelise Barrios, MD, PhD1, Dr. Victor Matheu, MD2, Dr. Andres Franco, MD1, Dr. Esmeralda Delgado, MD3 and Dr. Sagrario Bustabad, MD3, 1Immunology, Hospital Universitario de Canarias, LA LAGUNA, Spain, 2Allergy Section, Hospital Ofra, Tenerife, Spain, 3Rheumatology, Hospital Universitario de Canarias, LA LAGUNA, Spain Circulating Endothelial and Platelet Microparticles For Diagnosis and Monitoring Vasculitis Prof. El-Desouki E. Fouda, MD, FAAAAI, Al-Azhar university Allergy & Immunology Cr., Cairo, Egypt, Dr. Marwa Ahmed, Alazhar Allergy&Immunology Cr., Cairo, Egypt and Prof. Mona Alrayes, Al-Azhar Allergy& Immunology Cr.,, Cairo, Egypt Mistaken Identity: Misdiagnosis Based On Auto-Antibodies In IVIG Dr. Kristyn E. Anthony, MD, Tulane University, New Orleans, LA and Dr. Jane M. El-Dahr, MD, Tulane University School of Medicine, New Orleans, LA Th-17 Cytokines In Oral Lichen Planus Prof. G.N. Drannik1, Prof. A.I. Kurchenko1, Dr. R.A. Rehuretska1, Dr. A.G. Drannik2 and Prof. Lawrence M. DuBuske, MD,

Abstracts AB337

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

FAAAAI3, 1National Medical University, Kiev, Ukraine, 2National medical University, Kiev, Ukraine, 3George Washington University School of Medicine, DC 652

Airborne Allergen Exposures

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A Study On Allergy Sensitization Of Dense Urban Dwellers To Dog and Cat Allergens Using The Skin Prick Test Dr. Racquel Joy Y. So, Dr. Florecita Padua and Dr. Shirley Kwong, Fe Del Mundo Medical Center, Quezon City Rhinix Nasal Filters For The Treatment Of Allergic Rhinitis: A Randomized, Double-Blinded Placebo-Controlled Crossover Clinical Trial Peter Kenney, BSc1, Ole Hilberg, MD, DMSc2, Henrik Pedersen, PhD3, Ole Bækgaard Nielsen, PhD4 and Torben Sigsgaard, MD, PhD1, 1Department of Public Health, Aarhus University, Aarhus, Denmark, 2Department of Respiratory Diseases and Allergology, Aarhus University Hospital, Aarhus, Denmark, 3Department of Engineering - Signal Processing, Aarhus University, Aarhus, Denmark, 4Department of Biomedicine, Aarhus University, Aarhus Airborne Allergen Exposure As a Quantum Phenomenon Dr. Gert Doekes, PhD, Institute for Risk Assessment Sciences, University Utrecht, NL, Utrecht, Netherlands, Dr. Peter S. Thorne, PhD, University of Iowa, Iowa City, IA, Dr. Ingrid Sander, PhD, Institute for Prevention and Occupational Medicine, Ruhr-University Bochum, Bochum, Germany, Dr. Inge Wouters, PhD, Institute for Risk Assessment Sciences, University Utrecht, Utrecht, Netherlands, Dr. Wijnand Eduard, PhD, National Institute of Occupational Health, Oslo, Norway and Dr. Dick Heederik, PhD, Institute for Risk Assessment Sciences, Utrecht, Netherlands Computer-Aided Design Of An Allergen Challenge Theatre William H. Yang, MD, Jimmy Yang, MBA, Robert Perrins, P.Eng, Suzanne Kelly, PhD and Jacob Karsh, MD, Red Maple Trials Inc., Ottawa, ON, Canada Evaluation Of a Compact Ionic Capture Device For Airborne Allergens In Inner City Schools Dr. Julian Gordon, PhD1, Ms. Prasanthi Gandhi, MBA MPH1, Dr. Gajendra Shekhawat, PhD2, Ms. Ann Bailey, BA3 and Dr. Wanda Phipatanakul, MD, MS, FAAAAI4, 1Inspirotec LLC, Chicago, IL, 2 Northwestern University, Evanston, IL, 3Channing Laboratory, Boston, MA, 4Boston Children’s Hospital, Boston, MA Relevance Of Sensitization To Blomia Tropicalis, Dermatophagoides and Tropomyosin- Containing Antigens Among Atopics Living In a Tropical Region Dr. Beverly K. Di Giorgi, MD, Dr. Sylvette Nazario, MD, Dr. Fernando J. Lopez, MD and Dr. Javier A. Mendez, MD, University of Puerto Rico School of Medicine, San Juan, PR Update In The Prevalence Of Atopic Conditions, IgE Levels and Skin Test Sensitization To Aeroallergens In Northern Puerto Rico Dr. Rafael H. Zaragoza, MD, PhD, Doral Bank Center, San Juan, PR; University of Puerto Rico School of Medicine, San Juan, PR Stability Of Immunoassay Analytes and Test Kits Used For Monitoring Environmental Allergen Exposure Bryan Smith, Denise Block, Stephanie Filep, Dr. Martin D. Chapman, PhD FAAAAI and Dr. Eva-Maria King, PhD, Indoor Biotechnologies, Inc., Charlottesville, VA Factors Affecting Pollen Rupture and Protein Release From Allergenic Pollens Ms. Umaporn Siriwattanakul, Master of Science Program in Plant Science, Department of Plant Science, Faculty of Science and Department of Pharmaceutical Botany, Faculty of Pharmacy, Mahidol

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Cytokine Profiles In Bronchoalveolar Lavage In a Mouse Model Of Bronchial Asthma During A(H1N1)pdm09 and Seasonal H1N1 Infection Dr. Shunji Hasegawa1, Dr. Seigo Okada2, Dr. Hiroyuki Wakiguchi2, Dr. Hideki Hasegawa3, Dr. Akira Ainai4, Dr. Komei Shirabe5, Dr. Shoichi Toda5, Dr. Ryo Atsuta6, Dr. Akihiro Hasegawa7 and Dr. Takashi Ichiyama1, 1Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan, 2Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 3Department of Pathology, National Institute of Infectious Diseases, 4 Influenza Virus Research Center, National Institute of Infectious Diseases, 5Yamaguchi Prefectural Institute of Public Health and Environment, 6Department of Respiratory Medicine, Juntendo University School of Medicine, 7Department of Microbiology and Immunology, Yamaguchi University Graduate School of Medicine In Vitro Tumor Necrotic Factor Alpha Responses To Persistent Chlamydia Pneumoniae Infection From PBMC Of Asthmatic Children Dr. Kobkul Chotikanatis, MD1, Dr. Diana Weaver, MD2, Danielle Lent3, Eva Estrella3, Dr. Margaret R. Hammerschlag, MD3, Dr. Rauno O. Joks, MD, FAAAAI1,4 and Dr. Stephan Kohlhoff, MD5,6, 1 SUNY Downstate Medical Center, Center for Allergy and Asthma Research, Brooklyn, NY, 2Kings County Hospital Center, Brooklyn, NY, 3SUNY Downstate Medical Center, Brooklyn, NY, 4Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, NY, 5Center for Allergy and Asthma Research, State University of New York Downstate Medical Center, Brooklyn, NY, 6 Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY Human Rhinoviruses/Enteroviruses Associated Wheezing In Children Anyarat Wanitchakorn, MD1, Dr. Wiparat Manuyakorn, MD1, Wasu Kamchaisatian, MD1, Dr. Wasun Chantratita2, Kanjana Premchaiporn2 and Suwat Benjaponpitak, MD1, 1Division of Pediatric Allergy/Immunology/Rheumatology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 2Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Study Of Montelukast For The Treatment Of Acute and Post Viral-Induced Wheezing Sirirak Kanchanateeraphong, MD, Gun Phongsamart, MD, Tassalapa Dangsuwan, MD and Mukda Vangveeravong, MD, Queen Sirikit National Institute of Child Health(Children Hospital), Bangkok, Thailand

MONDAY

4205 Monday, March 3rd, 2014, 9:45 AM - 10:45 AM

University, Bangkok, Thailand and Dr. Wisuwat Songnuan, Department of Plant Science, Faculty of Science, Mahidol University, Bangkok, Thailand Attitudes and Behaviors Among Patients With Confirmed Pet Allergy Dr. Timothy J. Campbell, MD, Dr. Asaf Klein, MD, Xiaofeng Wang, PhD, Qi Zhang, M.S. and Dr. Roxana Siles, MD, Cleveland Clinic Uniformed Distribution Of Aerosolized Dust Mite Allergen In The Allergen Biocube (ABC) Keith Lane, Ora Inc., MA, Paul Gomes, Ora Inc., Endri Angjeli, Ora, Inc, Andover, MA and Dr. Anne K. Ellis, MD, MSc FAAAAI, Allergy Research Unit, Kingston General Hospital, Kingston, ON, Canada; Departments of Medicine and Biomedical & Molecular Science, Queen’s University, Kingston, ON, Canada

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Prevalence Of Toxocara Infection In Subjects With Suspected Allergies Dr. Rosanna M. Qualizza, Istituti Clinici di Perfezionamento, Milano, Italy, Dr. Cristoforo Incorvaia, Istituti Clinici di perfezionamento, Milano, Italy and Dr. Anna Maraschini, IRCCS Fondazione Ca’Granda Policlinico, Milano, Italy The Effects Of Dexamethasone On Community-Acquired Pneumonia In Children Prof. Youn Ho Shin, Department of Pediatrics, CHA Medical Center, CHA University School of Medicine, Seoul, Korea, South Korea, Dr. Jun Hwan Kim, Department of Pediatrics, CHA University School of Medicine, South Korea, Dr. Jung Won Yoon, Department of Pediatrics, Myongji Hospital, Gyeonggi-do, South Korea, Prof. Sun-Hee Choi, MD, PhD, Gangdong Kyung Hee University Hospital, Seoul, South Korea, Dr. Hyeung Yoon Kim, Department of Pediatrics, Bundang Jaesaeng Hospital, Seongnam, South Korea, Hye Mi Jee, MD, Department of Pediatrics, CHA University School of Medicine, Seongnam, Korea, South Korea, Prof. Man-Yong Han, MD, PhD, Department of Pediatrics, CHA University School of Medicine, Seongnam, South Korea and Dr. Jin-Tack Kim, MD, PhD, Department of Pediatrics, Uijeongbu St. Mary’s Hospital, The Catholic University of Korea, College of Medicine, Uijeongbu, Gyeonggi-Do, South Korea The Association Between Strongyloides Stercoralis Infection and Allergic Skin Diseases Dr. Lahari Rampur, MD, Albert Einstein/Jacobi medical centre, Bronx, NY, Dr. Gabriele De Vos, MD, Albert Einstein College of Medicine, Bronx, NY, Dr. Golda Hudes, MD, PhD, Albert Einstein/ Montefiore Medical Center, New York, NY and Dr. Sunit Jariwala, MD, Albert Einstein/Montefiore Medical Center, New York, NY Effects Of Human Rhinovirus Species On Cytokine Production and Cellular Cytotoxicity In Differentiated Sinus Epithelial Cells Dr. Kazuyuki Nakagome, MD1,2, Dr. Yury Bochkov, PhD1, Dr. Shamaila Ashraf, PhD1, Ms. Rebecca Brockman-Schneider, MS1 and Dr. James E. Gern, MD, FAAAAI1, 1University of Wisconsin School of Medicine and Public Health, Madison, WI, 2Saitama Medical University, Saitama, Japan Human Rhinovirus Bronchiolitis Predominant In Very Low Birthweight Infants In Argentina Dr. Jodell E Linder-Jackson, PhD1, Tatyana E Plachco2, Lucrecia Bossi3, Gabriela Bauer2, Fernando P Polack4, Romina P Libster5 and Eva K Kathryn Miller, MD, MPH6, 1Vanderbilt, TN, 2Hospital de Pediatrıa Garrahan, Argentina, 3Maternidad Sarda, Argentina, 4 Fundacion Infant, Vanderbilt University, Argentina, 5Fundacion Infant, Argentina, 6Vanderbilt University Medical Center, Nashville, TN Association Of Vitamin D Status With Recurrent Wheezers and Lower Respiratory Infection In Pre-School Children Prof. Jin-A Jung, MD, Dong-A University College of Medicine, Busan, Prof. Ja Hyeong Kim, MD, Ulsan University Hospital, Ulsan, South Korea and Prof. Ju-Suk Lee, MD, PhD, Sungkyunkwan university, Changwon, South Korea

Immune Mediated Skin Diseases 4207 Monday, March 3rd, 2014, 9:45 AM - 10:45 AM 664

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Safety and Efficacy Of Dupilumab Versus Placebo For Moderate-To-Severe Atopic Dermatitis In Patients Using Topical Corticosteroids (TCS): Greater Efficacy Observed With Concomitant Therapy Compared To TCS Alone Dr. Diamant Thaci, MD1, Dr. Margitta Worm, MD2, Dr. Haobo Ren, PhD3, Dr. Steven Weinstein, MD, PhD4, Dr. Neil Graham,

J ALLERGY CLIN IMMUNOL FEBRUARY 2014

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MD4, Dr. Gianluca Pirozzi, MD, PhD5, Warren Brooks, PhD4 and Dr. Marius Ardeleanu, MD4, 1Universit€at zu L€ ubeck, Lubeck, Germany, 2Charite - Universit€atsmedizin Berlin, Berlin, Germany, 3Regeneron Pharmaceuticals, Inc., Basking Ridge, NJ, 4 Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 5Sanofi, Bridgewater, NJ A Lipid Plant Extract From Chamaecyparis Obtusa Induces Filaggrin and Human Beta-Defensin -3 Mr. Byung Eui Kim, MD, PhD1, Mr. Gwui Cheol Kim, PhD2, Ms. Hee Jin Kim2 and Donald Y.M. Leung, MD, PhD, FAAAAI1, 1National Jewish Health, Denver, CO, 2Jeonnam Nano Bio Research Center Identification Of Novel Gene Signatures In Atopic Dermatitis Complicated By Eczema Herpeticum Dr. Lianghua Bin, MD, PhD1, Dr. Michael G Edwards2, Dr. Ryan Heiser, PhD1, Mrs. Joanne Streib, BA1, Ms. Brittany Richers1 and Donald Y.M. Leung, MD, PhD, FAAAAI1, 1National Jewish Health, Denver, CO, 2University of Colorado at Denver Topical Application Of Rapamycin Ointment Inhibits Dermatophagoides Farinae Body (Dfb) Extract Antigen-Induced Dermatitis In NC/Nga Mice Mr. Fei Yang1, Dr. Lingli Yang1, Dr. Mari Tanaka1, Dr. Mari Wataya-Kaneda1, Ayumi Nakamura2, Shoji Matsumoto2, Dr. Mostafa Attia3, Dr. Hiroyuki Murota1 and Prof. Ichiro Katayama1, 1Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan, Osaka, Japan, 2Osaka University Hospital, Department of Pharmacy, Osaka, Japan, 3Dermatology, Cairo University, Cairo, Egypt, Cairo, Egypt Therapeutic Effects Of Recombinant Salmonella Typhimurium Expressing TLR8 miRNA On Atopic Dermatitis Dr. Wonsuck Yoon, Department of Life Science and Biotechnology, Seoul, South Korea, Prof. Ji Tae Choung, MD, Korea Univ. Medical Center, Seoul and Dr. Young Yoo, MD, PhD, Department of Pediatrics, College of Medicine, Korea University, Seoul, South Korea Correlation Between Serum 25-Hydroxyvitamin D Levels and Severity Of Allergic Atopic Dermatitis In Children Dr. Sung Soon, BUSAN MARY, BUSAN, South Korea Association Between Prenatal and Early Life Vitamin D Levels and Allergic Outcome At Age 2 Years Ganesa Wegienka, PhD1, Ms. Suzanne Havstad, M.A.1, Kimberley J. Woodcroft, PhD1, Dr. Dennis Ownby, M.D. FAAAAI2, Dr. Edward M. Zoratti, MD, FAAAAI3 and Dr. Christine Cole Johnson, PhD MPH FAAAAI1, 1Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, 2Department of Pediatrics Georgia Regents University, Augusta, GA, 3Henry Ford Health System, Detroit, MI Association Between Sun Exposure During The First 6 Months Of Life and The Cumulative Incidence Of Atopic Dermatitis In Infants Dr. Miwa Shinohara, MD, PhD, Department of Pediatric Allergy and Clinical Research, Shimoshizu National Hospital, Yotsukaido, Japan and Dr. Kenji Matsumoto, MD, PhD, Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan Dampness In The Water-Damaged Homes Affects The Severity Of Atopic Dermatitis In Children Prof. Sungchul Seo, The Enviornmental Health Center for Asthma, Korea University, Seoul, Prof. Ji Tae Choung, MD, Korea Univ. Medical Center, Seoul, Dr. Young Yoo, MD, PhD, Department of Pediatrics, College of Medicine, Korea University, Seoul, South Korea, Dr. Wonsuck Yoon, Department of Life Science and Biotechnology, Seoul, South Korea, Prof. Kangmo Ahn, MD, PhD, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea and Dr. Jihyun Kim, MD, Samsung Medical Center, Seoul

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Mycotoxin Aggravates Atopic Dermatitis Via TSLP Induced Th2 Inflammation Ms. Seung-Hwa Lee1, Ms. Ha-Jung Kim1 and Prof. Soo-Jong Hong, MD. PhD2,3, 1Asan Institute for Life Sciences, University of Ulsan College of Medicine, 2Department of Pediatrics, Asan Medical Center, Childhood Asthma Atopy Center, South Korea, 3 Research Center for Standardization of Allergic Disease, University of Ulsan College of Medicine, Seoul, Korea Early Skin Care By ‘‘Experienced Mothers’’ May Prevent Sensitization In Infants With Atopic Dermatitis Dr. Atsushi Yamashita, Dr. Mizuho Nagao, MD, Ms. Kanae Furuya, Dr. Junya Hirayama, Dr. Keigo Kainuma, MD and Dr. Takao Fujisawa, MD, FAAAAI, Institute for Clinical Research, Mie National Hospital Association Of Bathing Habits To Pruritus and Allergic Disease Dr. Kanwaljit K. Brar, MD1, Dr. Rauno O. Joks, MD, FAAAAI2 and Dr. Hamid Moallem, MD1, 1SUNY Downstate Medical Center, Brooklyn, NY, 2Center for Allergy and Asthma Research, State University of New York Downstate Medical Center, Brooklyn, NY A Molecular Mechanism Underlying Atopic Dermatitis In Hyper-IgE Syndrome Masako Saito, PhD, Division of Molecular Medicine, Institute for Genome Research, The University of Tokushima, Tokushima, Japan, Dr. Hajime Karasuyama, MD, PhD, Tokyo Medical and Dentistry Graduate School, Tokyo, Japan and Dr. Yoshiyuki Minegishi, MD and PhD, Division of Molecular Medicine, Institute for Genome Research, The University of Tokushima Racial Differences In The Relationship Of Total and Food-Specific IgE To Atopic Dermatitis In Childhood Dr. Gillian Bassirpour, MD1, Dr. Edward M. Zoratti, MD, FAAAAI2, Ganesa Wegienka, PhD3, Ms. Suzanne Havstad, M.A.3, Alexandra Sitarik, M.S.3, Dr. Haejin Kim, MD1, Dr. Dennis Ownby, M.D. FAAAAI4 and Dr. Christine Cole Johnson, PhD MPH FAAAAI3, 1Division of Allergy and Clinical Immunology, Henry Ford Hospital, Detroit, MI, 2Henry Ford Health System, Detroit, MI, 3Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, 4Department of Pediatrics Georgia Regents University, Augusta, GA Major Culprit Allergen Sensitization Patterns According To Age In Korean Atopic Dermatitis Patients Hye Jung Park1, Jae-Hyun Lee1,2, Kyung-Yong Jeong2, KyungHee Park1,2, Yoon-Ju Kim2 and Jung-Won Park1,2, 1Division of Allergy and Clinical Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 2Institute of Allergy, Yonsei University College of Medicine, Seoul, South Korea Protein Microarray: IgE-Profiling Of Brazilians With Atopic Dermatitis Lucila Camargo Lopes de Oliveira1, Roberta Faria Camilo-Araujo1, Isabel Rugue Genov1, Dr. Renata R. Cocco2, Dr. Marcia Mallozi, MD3, Prof. Nelson A. Rosario, MD, PhD, FAAAAI4 and Prof. Dirceu Sole, MD, PhD5, 1UNIFESP, 2Federal University of S~ao Paulo, 3Federal University of S~ao Paulo, Brazil, 4Federal University of Parana, Curitiba, Brazil, 5Federal University of Sao Paulo, Sao Paulo, Brazil Relationship Between Dietary Food and Nutrient Intakes and Bone Mineral Density In Childhood Eczema Dr. Ting Fan Leung, MD FRCPCH FAAAAI, Ms. Flora Yin-ying Kwok, MPhil, Dr. Yvonne Yi-fong Ho, MPhil, Dr. Susan Shuxin Wang, PhD, Ms. Patty Pui-pui Tse, MSc, Prof. Gary Wing-kin Wong, MD, FRCPC and Dr. Kam Lun Ellis Hon, MD, FAAP, Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong Change Of Caregiver’s Perception Regarding Atopic Dermatitis From 2006 To 2013 Dr. Kyung Suk Lee, MD, PhD1, Prof. Yeong-Ho Rha, MD, PhD1 and Prof. Sun-Hee Choi, MD, PhD2, 1Kyung Hee University

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Hospital, 2Gangdong Kyung Hee University Hospital, Seoul, South Korea Excellent Agreement Between Dermatology and Pediatric Researchers In Severity Scoring Of Atopic Dermatitis (SCORAD) Index In Children Dr. Rodrigo Hoyos Bachiloglu, MD1, Dr. Cristian Navarrete, MD2, Dr. Cristian Vera, MD2, Dr. Sergio Silva, MD2, Dr. Lorena Cifuentes, MD1, Mrs. Carolina Iturriaga, RN1, Ms. Francisca Cristi, MSc1 and Dr. Arturo Borzutzky, MD1, 1Division of Pediatrics, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile, 2Department of Dermatology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile A Case Of Recurrent Severe Poison Ivy Contact Dermatitis, Treated Successfully With Seasonal Cyclosporine Dr. Jaron T. Abbott, MD, Dr. Yuriy Zgherea, MD and Dr. Selina Gierer, DO, University of Kansas Medical Center Allergic Contact Stomatitis From Orthodontic Adhesives Dr. Priscilla H. Wong, MD1, Dr. Scott D. Dickson, DO2 and Dr. Christopher A. Coop, MD1, 1Wilford Hall Ambulatory Surgical Center, Lackland AFB, TX, 256th Medical Group, Luke AFB, AZ Contact Dermatitis Due To Topical Amorolfine Dr. Ruperto Gonzalez Perez, Mrs. Paloma Poza-Guedes, Mrs. Inmaculada Sanchez Machın and Dr. Victor Matheu, MD, Hospital del Torax-Ofra, Sta Cruz de Tenerife, Spain Sweet’s Syndrome By A Show Of Hands Dr. Syeda Hamadani, Dr. Anita Ravi, Dr. Seth Politano, Dr. Eric Hsieh and Dr. Gina Rossetti, USC, Los Angeles, CA Mango, Pulp Fiction? Dr. Alexander S. Kim, MD, University of California San Diego, La Jolla, CA and Dr. Sandra C. Christiansen, MD, FAAAAI, Southern CA Permanente Med Grp, San Diego, CA Preoperative Patch Testing In Patients Undergoing Pectus Excavatum Repair Dr. Laura Helfner, MD1, Dr. David Rosenthal, DO1, Dr. Blanka M. Kaplan, MD, FAAAAI2 and Dr. Punita Ponda, MD, FAAAAI3, 1 Division of Allergy/Immunology, Departments of Medicine and Pediatrics, Hofstra North Shore-LIJ School of Medicine, Great Neck, NY, 2Department of Pediatrics, Division of Allergy & Immunology, Hofstra-North Shore-LIJ School of Medicine, Great Neck, NY, 3Allergy and Immunology, North Shore LIJ Health System, Great Neck, NY

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Abstracts AB339

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

Oral Allergy Syndrome - a Spectrum Of Presentations Dr. Parwinder Gill1, Dr. Gordon L. Sussman, FAAAAI2, Jiayi Bian1 and Ms. Carly Barron3, 1University of Toronto, Toronto, ON, Canada, 2University of Toronto, Faculty of Medicine, Toronto, ON, Canada, 3Gordon Sussman Clinical Research Inc., Toronto, ON, Canada Allergy To Sheep Milk With Or Without Allergy To Cow Milk Dr. Fouseena Pazheri1, Dr. Alton Lee Melton Jr., MD2, Dr. Earl Poptic1 and Dr. Belinda Willard1, 1Cleveland CLinic, Cleveland, OH, 2Cleveland Clinic, Cleveland, OH Genome-Wide Study Of Interaction Between Season Of Birth and Peanut Allergy Identifies a Region On Chromosome 3 As a Genetic Risk Factor Corinne Keet, MD, MS1, Xiumei Hong, PhD2, Dr. Ingo Ruczinski, PhD2, Dr. Terri H Beaty, PhD2, Dr. Jacqueline Pongracic, MD, FAAAAI3 and Dr. Xiaobin Wang, MD, MPH ScD4, 1Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, 2 Johns Hopkins University School of Public Health, Baltimore,

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MD, 3Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 4Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD Orofecal Infections and Risk Of Food Allergy In Children Dr. Gary Wong, MD1, Dr. Jing Li, MD, MSc2, Dr. Ting Fan Leung, MD FRCPCH FAAAAI3 and Prof. Nanshan Zhong2, 1Chinese University of Hong Kong, Shatin, Hong Kong, 2The First Affiliated Hospital of Guangzhou Medical College, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, Guangzhou, China, 3Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong Peanut, Milk, and Wheat Intake During Pregnancy Is Associated With Reduced Allergy and Asthma In Children Dr. Supinda Bunyavanich, MD, MPH1, Ms. Sheryl Rifas-Shiman, MPH2, Thomas A.E. Platts-Mills, MD, PhD, FAAAAI3, Lisa J. Workman, BA3, Dr. Joanne Sordillo, ScD4, Dr. Carlos Camargo Jr., MD, DrPH5, Dr. Matthew Gillman, MD, SM2, Dr. Diane R. Gold, MD, MPH6 and Dr. Augusto A. Litonjua, MD, MPH4, 1Division of Pediatric Allergy & Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 2Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA, 3Division of Asthma, Allergy & Immunology, University of Virginia Health System, Charlottesville, VA, 4Channing Division of Network Medicine, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, 5Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 6Channing Laboratory, Brigham and Women’s Hospital, Boston, MA The Prevalence Of Food Sensitization and Food Allergy In An Inner City Birth Cohort Robert A. Wood, MD, FAAAAI, Johns Hopkins University Medical Center, Baltimore, MD, Dr. Emily C. McGowan, MD, Johns Hopkins University School of Medicine, Baltimore, MD, Dr. Gordon R. Bloomberg, MD, FAAAAI, Campus Box 8116, St. Louis Children’s Hospital, Saint Louis, MO, Dr. Peter J. Gergen, MD, MPH, AAIB\DAIT\NIH, Bethesda, MD, Dr. Cynthia Visness, PhD, Rho Federal Systems Division, Inc., Chapel Hill, NC, Katy Jaffee, MS, Rho, Inc., Chapel Hill, NC, Dr. George T. O’Connor, MD, Boston University School of Medicine, Boston, MA, Dr. Meyer Kattan, MD, NewYork-Presbyterian/Columbia, New York, NY and Dr. James E. Gern, MD, FAAAAI, University of Wisconsin School of Medicine and Public Health, Madison, WI Food Allergy Prevalence In Parents Of Food-Allergic Children Based On Self-Report, Serologic Testing and Physician Diagnosis Melanie M. Makhija, MD1,2, Dr. Rachel Glick Robison2,3, Deanna Caruso, MS4, Miao Cai, MS5, Dr. Xiaobin Wang, MD, MPH ScD4 and Dr. Jacqueline Pongracic, MD, FAAAAI3,6, 1Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 2Division of Allergy & Immunology, Department of Pediatrics,Northwestern University Feinberg School of Medicine, Chicago, IL, 3Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 4Johns Hopkins University School of Public Health, Baltimore, MD, 5Division of Allergy & Immunology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 6Division of Allergy & Immunology, Department of Pediatrics,Northwestern University Feinberg School of Medicine The Effect Of Neighborhood Level Poverty and Urbanization On The Prevalence Of Food Allergy In The National Health Interview Survey (NHIS) Dr. Emily C. McGowan, MD1, Dr. Meredith C. McCormack, MD2, Dr. Roger Peng, PhD3, Dr. Elizabeth Matsui, MD2 and Corinne Keet, MD, MS4, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2The Johns Hopkins University School of Medicine, Baltimore, MD, 3Johns Hopkins School of Public Health,

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Baltimore, MD, 4Johns Hopkins University Medical Center, Baltimore, MD Prevalence Of IgE-Mediated Food Sensitisation and Food Allergy In Unselected 12-36 Month Old South African Children Dr. Maresa Botha, MBChB, FCPaed1 and Prof. Michael E. Levin, MBChB, FCPaed, Dip Allergology, MMed(Paeds), PhD, EAACI allergy exam (UEMS), Certificate Allergology, FAAAAI1,2, 1University of Cape Town, Cape Town, South Africa, 2Red Cross War Memorial Children’s Hospital, Cape Town, South Africa Evaluation Of Peanut Allergy In a Birth Cohort Dr. Hiba Bashir, MD1, Mr. Christopher J. Tisler, MT1, Dr. Elizabeth L. Anderson1, Dr. Theresa Kang, PhD1, Lisa Salazar, BS1, Mr. Michael D. Evans, MS1, Dr. Ronald E. Gangnon, PhD1, Dr. Daniel J. Jackson, MD2, Dr. Robert F. Lemanske Jr., MD, FAAAAI1 and Dr. James E. Gern, MD, FAAAAI1, 1University of Wisconsin School of Medicine and Public Health, Madison, WI, 2Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI Prevalence Of Peanut Allergy: A Systematic Review Dr. Heather Mackenzie1, Dr. Carina Venter, PhD RD2, Dr. Sally Kilburn1, Ms. Harriet R. Moonesinghe1, Ms. Kellyn Lee1 and Prof. Taraneh Dean1,3, 1University of Portsmouth, School of Health Sci, Portsmouth, United Kingdom, 2The David Hide Asthma and Allergy Research Center, Isle of Wight, United Kingdom, 3The David Hide Asthma and Allergy Centre, Newport Prevalence Of Fish and Shellfish Allergy- A Systematic Review Ms. Harriet R. Moonesinghe1, Dr. Sally Kilburn1, Dr. Heather Mackenzie1, Dr. Paul J. Turner, FRACP PhD2, Dr. Carina Venter, PhD RD3, Ms. Kellyn Lee1 and Prof. Taraneh Dean1, 1University of Portsmouth, School of Health Sci, Portsmouth, United Kingdom, 2 Imperial College London, United Kingdom, 3The David Hide Asthma and Allergy Research Center, Isle of Wight, United Kingdom Prevalence Of Food Allergy To Uncommon Foods Based On Oral Food Challenges Dr. Gita Ram1, Christina Gustafson1, Dr. Jonathan M. Spergel, MD, PhD, FAAAAI2 and Dr. Antonella Cianferoni, MD, PhD3, 1 Children’s Hospital of Philadelphia, Philadelphia, PA, 2The Children’s Hospital of Philadelphia, Philadelphia, PA, 33615 Civic Center Boulevard, The Children’s Hospital of Philadelphia, Philadelphia, PA Prevalence Of Food Allergy In Patients With Irritable Bowel Syndrome Erin L. Reigh, MD, MS1, Dr. Javed Sheikh, MD, FAAAAI2 and Anna Kovalszki, MD1, 1Beth Israel Deaconess Medical Center, Boston, MA, 2Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA Clinical Characteristics Of Seafood Allergy In Canadian Children Dr. Victoria Cook, Department of Pediatrics, University of British Columbia, BC Children’s Hospital, Vancouver, BC, Canada, Dr. Edmond S. Chan, MD, FAAAAI, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Dr. Ann Elaine Clarke, MD, MSc, Division of Allergy and Clinical Immunology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada; Division of Clinical Epidemiology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada, Mr. Greg Shand, Department of Medicine, Division of Clinical Epidemiology, McGill University Health Center, Montreal, QC, Canada and Dr. Moshe Ben-Shoshan, MD, MSc, Division of Paediatric Allergy and Clinical Immunology, Department of Paediatrics, McGill University Health Center, Montreal, QC, Canada Changes In Total IgE Levels To Predic Food Challenge Test Outcomes Dr. Kenta Horimukai, Jikei University Katsushika Medical Center, Tokyo, Japan, Dr. Masami Narita, MD, PhD, National Center for Child Health and Development, Tokyo, Japan, Dr. Ichiro

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Nomura, MD, PhD, National Center for Child Health and Development, Setagayaku, Japan, Dr. Kenji Matsumoto, MD, PhD, Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan and Dr. Yukihiro Ohya, MD, PhD, Division of Allergy, National Center for Child Health and Development, Tokyo, Japan Situational and Environmental Factors Associated With a Child’s Willingness To Use An Epinephrine Auto-Injector Amanda Tantleff, Byram Hills High School and Dr. Anna H. Nowak-Wegrzyn, MD, FAAAAI, Icahn School of Medicine at Mount Sinai, New York, NY Possession Of Epinephrine Auto-Injectors (EAI) In a Vulnerable Canadian Population With Food Allergies Dr. Sabrine Cherkaoui, M.D1, Ms. Lianne Soller, MSc2, Dr. Moshe Ben-Shoshan, MD, MSc3, Daniel Harrington, MA, PhD4, Dr. Sebastien La Vieille, MD5, Dr. Joseph Fragapane, MD6, Dr. Lawrence Joseph, PhD7, Mr. Yvan St-Pierre, MSc8, Prof. Susan Elliott, PhD9 and Dr. Ann Elaine Clarke, MD, MSc7,10, 1Division of Internal Medicine, Department of Medicine, University of Montreal, Montreal, QC, Canada, 2Division of Clinical Epidemiology, Department of Medicine, McGill University Health Center, Montreal, QC, Canada, 3Division of Paediatric Allergy and Clinical Immunology, Department of Paediatrics, McGill University Health Center, Montreal, QC, Canada, 4McMaster University - School of Geography, Hamilton, ON, Canada, 5Food Directorate, Health Canada, Ottawa, ON, Canada, 6McGill University, Dorval, QC, Canada, 7 Division of Clinical Epidemiology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada, 8Division of Clinical Epidemiology, Department of Medicine, McGill University Health Center, Canada, 9Applied Health Sciences, University of Waterloo, ON, Canada, 10Division of Allergy and Clinical Immunology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada Food Allergy In Daycare Centers: Prevalence, Management, and Knowledge Of Directors Dr. Lisanne Newton, M.D. and Dr. Brian Schroer, MD, Cleveland Clinic, Cleveland, OH Assessment Of Food Insecurity and Health Literacy In a Tertiary Care Pediatric Allergy Population Dr. Meredith A. Dilley, MD1,2, Ms. G. Lynn Christie, MS RD2, Ms. Mary Price2, Ms. Connelly Weeks2, Mallikarjuna Rettiganti, PhD1,2, Maria Melguizo Castro1,2, Dr. Amy M. Scurlock, MD3,4, Dr. Tamara T. Perry, MD1,2, Dr. Robbie D. Pesek1,2, Dr. Matthew C. Bell, MD1,2, Joshua L. Kennedy, MD5, Ms. Erin O’Brien1,2, Ms. Sklar McGrath2, Mr. Jared Hogan2, Megan Patterson1, Julia Aronson1, Dr. Patrick Casey, MD1,2 and Stacie M. Jones, MD3,5, 1University of Arkansas for Medical Sciences, Little Rock, AR, 2 Arkansas Children’s Hospital, Little Rock, AR, 3University of Arkansas for Medical Sciences and Arkansas Children’s Hospital, Little Rock, AR, 4University of Arkansas for Medical Sciences/ Arkansas Children’s Hospital, Little Rock, AR, 5Arkansas Children’s Hospital Research Institute, Little Rock, AR Environmental and Sociodemographic Factors Associated With Food Allergy: A Nested Case-Control Study Dr. Moshe Ben-Shoshan, MD, MSc1,2, Ms. Lianne Soller, MSc3, Daniel Harrington, MA, PhD4, Ms. Megan Knoll, MSc5, Dr. Sebastian La Vieille, MD6, Dr. Joseph Fragapane, MD7, Dr. Lawrence Joseph, PhD8,9, Mr. Yvan St. Pierre, MSc10, Dr. Kathi Wilson11, Prof. Susan Elliott, PhD12 and Dr. Ann Elaine Clarke, MD, MSc8,13, 1Division of Paediatric Allergy and Clinical Immunology, Department of Paediatrics, McGill University Health Center, Montreal, QC, Canada, 2Montreal Children’s Hospital, Montreal, Canada, 3Division of Clinical Epidemiology, Department of Medicine, McGill University Health Center, Montreal, QC, Canada, 4McMaster University - School of Geography, Hamilton, ON, Canada, 5Division of Clinical Epidemiology, Department of Medicine, McGill University Health Center, Canada, 6Food

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Directorate, Health Canada, Ottawa, ON, Canada, 7McGill University, Dorval, QC, Canada, 8Division of Clinical Epidemiology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada, 9McGill University, Montreal, QC, Canada, 10Division of Clinical Epidemiology, Department of Medicine, McGill University Health Center, QC, Canada, 11Department of Geography, University of Toronto, Toronto, ON, Canada, ON, Canada, 12 Applied Health Sciences, University of Waterloo, ON, Canada, 13 McGill University Health Centre, Montreal, Canada Differences In Empowerment and Quality Of Life Among Mothers and Fathers Of Children With Food Allergy Mr. Christopher Warren, BA1, Dr. Ruchi Gupta, MD, MPH2, Mr. Namit Lal3, Dr. Min-Woong Sohn, PhD4, Dr. Craig Garfield, MD4, Dr. Jacqueline Pongracic, MD, FAAAAI2 and Dr. Xiaobin Wang, MD, MPH ScD5, 1University of Southern California, Los Angeles, CA, 2Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 3University of Michigan, Ann Arbor, MI, 4Northwestern University, Chicago, IL, 5Johns Hopkins, Chicago, IL Prevalence Of Misconceptions Regarding Egg Allergy and Measles Mumos and Rubella Vaccine Contraindications Dr. Vylma Velazquez, MD, Dr. Carmen Rivera and Dr. Monique Adorno, Hospital Episcopal San Lucas, Ponce, PR Prenatal and Postnatal Factors Associated With IgE-Mediated Wheat Allergy In Infants: A Study In Asian Population Dr. Suparat Sirivimonpan, MD, Chulalongkorn University, Bangkok, Thailand Maternal Healthy Diet and Development Of Allergic Disease Dr. Carina Venter, PhD RD1, Ms. Harriet R. Moonesinghe2, Prof. Hasan Arshad3,4, Prof. Taraneh Dean2,5, Mrs. Jane Grundy3, Mrs. Gill Glasbey3 and Dr. Veeresh Patil3,4, 1The David Hide Asthma and Allergy Research Center, Isle of Wight, United Kingdom, 2University of Portsmouth, School of Health Sci, Portsmouth, United Kingdom, 3 The David Hide Asthma and Allergy Centre, Newport, United Kingdom, 4University of Southampton, Southampton, United Kingdom, 5 The David Hide Asthma and Allergy Centre, Newport Effect Of Annual Income On Parental/Family Burden Of Food Allergy Dr. David A. Petty, DO, University of Tennessee Allergy fellowship program, Memphis, TN, Jay A. Lieberman, MD, University of Tennessee, Memphis, TN and Nhu Quynh Tran, PhD, University of Tennessee Department of Preventative Medicine Food Allergy and Anaphylaxis Educational Needs Assessment, Training Curriculum and Assessment Of Knowledge Of Urban Child Care Center Workers Dr. Bruce J. Lanser, MD1, Dr. Ronina A. Covar, MD1, David Mark Fleischer, MD, FAAAAI1 and Dr. J. Andrew Bird, MD, FAAAAI2, 1National Jewish Health, Denver, CO, 2UT Southwestern Medical Center, Dallas, TX Food Allergy Survey Among Food Service Workers Bruce M. Prenner, MD1, John Hollingsworth, PA2, Ron Oliver3 and Linnet Brew, LVN1, 1Allergy Partners of San Diego, San Diego, CA, 2Scripps Clinic, 3The Marine Room, La Jolla, CA Bullying and Food Allergy – Longitudinal Follow-Up Scott H. Sicherer, MD, FAAAAI1, Melissa Rubes2, Chloe Mullarkey2, Mordechai Ambrose3, Noga Ravid2, Kelley Chuang3, Rachel Annunziato2 and Eyal Shemesh3, 1Mount Sinai School of Medicine, New York, NY, 2Fordham University, NY, 3Icahn School of Medicine at Mount Sinai, NY Prevalence and Characteristics of Consumer-Reported Food Allergic and Anaphylactic Events in CAERS, 2007-2011 Ms. Taiye M Oladipo, MPH and Dr. Stefano Luccioli, MD, FAAAAI, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD Impact Of School Peanut-Free Guidelines On Epinephrine Administration Dr. Lisa M. Bartnikas, MD1,2, Dr. Michelle F. Huffaker, MD1,3, Dr. William J. Sheehan, MD1,2, Dr. Watcharoot Kanchongkittiphon,

MONDAY

Abstracts AB341

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MD, PhD1,2, Mr. Carter Petty, MA2, Ms. Anne Sheetz, RN, BSN, MPH4, Dr. Robert Leibowitz, PhD4, Dr. Michael C. Young, MD, FAAAAI1,2 and Dr. Wanda Phipatanakul, MD, MS, FAAAAI1,2, 1 Harvard Medical School, Boston, MA, 2Boston Children’s Hospital, Boston, MA, 3Brigham and Women’s Hospital, Boston, MA, 4 Massachusetts Department of Public Health, Boston, MA Comparison Of Germfree and Conventional Mice For Evaluating The Potential Allergenicity Of Dietary Proteins Using Model Allergenic and Non-Allergenic Proteins Nathan L. Marsteller1,2, Mr. Kwame Andoh-Kumi1, Daniel A. Peterson3, Richard E. Goodman1 and Joe L. Baumert1, 1Food Allergy Research and Resource Program, University of Nebraska-Lincoln, Lincoln, NE, 2School of Biological Sciences, University of Nebraska-Lincoln, 3Johns Hopkins School of Medicine, Baltimore, MD The Role Of Lipopolysaccharide In Skewing The Sensitization Potential Of Purified b-Lactoglobulin In a Mouse Model Mr. Kwame Andoh-Kumi1, Richard E. Goodman1, Daniel A. Peterson2, Joe L. Baumert1 and Nathan L. Marsteller1,3, 1Food Allergy Research and Resource Program, University of Nebraska-Lincoln, Lincoln, NE, 2Johns Hopkins School of Medicine, Baltimore, MD, 3 School of Biological Sciences, University of Nebraska-Lincoln Oral Co-Administration Of Peanut and Cholera Toxin Subunit B During Pregnancy and Lactation Blocks Anaphylaxis and Induces Epigenetic Modifications In Peanut Allergic Murine Mothers Dr. Ying Song, MD1, Dr. ChangDa Liu1, Dr. Kamal D. Srivastava, PhD1, Dr. Jia Chen, ScD1,2, Dr. Rachel L. Miller, MD, FAAAAI3 and Dr. Xiu-Min Li, MD1, 1Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 2Prevention, Icahn School of Medicine at Mount Sinai, NY, 3Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, New York, NY Worsened Reaction Severity In Oral Food Challenges Confirms Need For In-Office Procedure Dr. Annie Esquivel, Dr. Girish V. Vitalpur, MD, FAAAAI, Dr. Kirsten Kloepfer, MD and Dr. Frederick E. Leickly, MD, MPH FAAAAI, Riley Hospital for Children at Indiana University Health, Indianapolis, IN Oral Food Challenge Outcome Among Children With a Negative Skin Prick Test Result Dr. Wipa Jessadapakorn, MD, Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat-Yai, Songkhla, Thailand, Dr. Prapasri Kulalert, MD, Prince of Songkla University, Songkla, Thailand, Dr. Araya Yuenyongviwat, MD, Prince of Songkla University, Songkhla, Thailand and Dr. Pasuree Sangsupawanich, MD, Prince Songkhlanagarind hospital, Hadyai, Thailand Abbreviated Oral Food Challenge As a Safe and Effective Alternative For Diagnosing Food Allergy In a Pediatric Clinic April L. Goolsby, BS1, Heather Minto, MD1,2, Amy Perkins, MS1,2 and Kelly M. Maples, MD1,2, 1Eastern Virginia Medical School, Norfolk, VA, 2Children’s Hospital of The King’s Daughters, Norfolk, VA Safety Of Ungraded Oral Food Challenges In Ruling Out Peanut Allergy In Children Dr. Darlene Kassab Mansoor, MD, MS1, Amit Singal, BS2, Shweta Bansil, BS2 and Dr. Hemant P. Sharma, MD MHS FAAAAI1, 1Children’s National Medical Center, 2George Washington University School of Medicine Safety Of Oral Food Challenges To Extensively Heated Egg In Children Dr. Cindy Nguyen, MD1, Shweta Bansil, BS2, Amit Singal, BS2 and Dr. Hemant P. Sharma, MD MHS FAAAAI3, 1Children’s National Medical Center, Division of Allergy and Immunology, Washington, DC, 2George Washington University School of Medicine, 3 Children’s National Medical Center, Division of Allergy and Immunology, DC

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Banana Allergy In Children Evaluated Using Double Blind Placebo Controlled Food Challenge Aysen Bingol, TURPEDAS, Turkey, Dilara Kocacik Uygun, AKDENIZ UNIVERSITY MEDICAL FACULTY DEPT OF PEDIATRIC ALLERGY IMMMUNOLOGY, Dr. Serkan Filiz, AKDENIZ UNIVERSITY MEDICAL FACULTY DEPT OF PEDIATRIC ALLERGY IMMUNOLOGY, ANTALYA, Turkey and Olcay Yegin, AKDENIZ UNIVERSITY MEDICAL FACULTY DEPT OF PEDIATRIC ALLERGY IMMUNOLOGY, Antalya, Turkey Risk Of Oral Food Challenges In Children - a Prospective Multicenter Study Dr. Toshiko Itazawa, MD, PhD1, Dr. Motokazu Nakabayashi, MD, PhD1, Dr. Yasunori Ito, MD, PhD1, Dr. Yoshie Okabe, MD, PhD1, Dr. Yoko S Adachi, MD, PhD1, Dr. Yuichi Adachi, MD, PhD1, Dr. Komei Ito, MD, PhD2 and Motohiro Ebisawa, MD, PhD, FAAAAI3, 1 Department of Pediatrics, University of Toyama, Toyama, Japan, 2 Aichi Children’s Health and Medical Center, Obu, Aichi, Japan, 3 Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan A Double-Blind Randomized Controlled Trial Of A Thickened Amino-Acid-Based Formula In Children Allergic To Cow’s Milk and To Protein Hydrolyzates Prof. Nicolas Kalach, MD, Ph D1, Dr. Elena Bradatan2, Prof. Alain Lachaux3, Dr. Francois Payot3, Prof. Frederic de BLAY4, Dr. Lydie Guenard-Bilbault5,6, Dr. Riad Hatahet7, Dr. Sandra Mulier8 and Prof. Christophe Dupont, MD, PhD9, 1H^opital Saint Vincent de Paul, Groupement des Hospitaux de l’Institut Catholique de Lille (GH-ICL), Lille, France, 2Department of Pediatrics, Regional Hospital, Namur, Belgium, 3Gastroenterology, Hepatology and Nutrition Unit, University and Pediatric Hospital of Lyon, France, 4 CHRU Strasbourg, France, 5Regional University Hospital, Strasbourg, Strasbourg, France, 6Allergologist, Illkirch-Graffenstaden, France, 7Pediatrician Allergologist, Forbach, France, 8Queen Fabiola Children’s, University Hospital, Brussels, Brussels, Belgium, 9 Hopital Necker Enfants Malades, Paris, France Impact Of Formula Containing Docosahexaenoic Acid, Prebiotics, and Beta-Glucan On Allergic Manifestations In Young Children Dr. Deolinda Scalabrin, MD, PhD1, Suzanne Stolz1, Weihong Zhuang1, Mariana Pontes2, Angela de Mattos2, Indhira Almeida2, Carolina Godoy2, Sara Gatto2, Vivian Leal2, Gabriela Cabral2, Tereza Ribeiro2 and Hugo Ribeiro2, 1Mead Johnson Nutrition, Evansville, IN, 2Federal University of Bahia, Brazil Parents’ Perception Of The Likelihood Of Future Life-Threatening Events In Their Children With Food Allergies Dr. Peter Arkwright, MD, PhD, FAAAAI1, Ms. Jennifer Ogg1, Dr. Naomi Davis2 and Dr. Ming Wan1, 1University of Manchester, Manchester, United Kingdom, 2Royal Manchester Children’s Hospital, United Kingdom Can Training Improve Allergists’ Ability To Accurately Identify Anxiety In Children With Food Allergy? Melissa Rubes1, Anna Podolsky2, Nicole Caso1, Rachel Annunziato1, Dr. Amanda L. Cox, MD2, Dr. Jennifer S. Kim, MD, FAAAAI2, Dr. Anna H. Nowak-Wegrzyn, MD, FAAAAI2, Dr. Julie Wang, MD, FAAAAI2, Scott H. Sicherer, MD, FAAAAI3 and Eyal Shemesh2, 1Fordham University, NY, 2Icahn School of Medicine at Mount Sinai, NY, 3Mount Sinai School of Medicine, New York, NY Nutritional Status Impairment In Patients With Food Allergies Dr. Gesmar Segundo, Mrs. Larissa Costa and Mrs. Erica Rezende, Universidade Federal de Uberlandia, Uberlandia, Brazil Everyday Life Impact On Food Allergy Spanish Children.Caregivers Perception Dr. Elena Alonso-Lebrero, PhD, Hospital Materno Infantil Gregorio Mara~non Pediatric Allergy Section, Madrid, Spain, Mr. Julio Monleon, MS, Santa Barbara, Madrid, Spain and Alberto AlvarezPerea, MD, Hospital Materno Infantil Gregorio Mara~non, Pediatric Allergy Department, Madrid, Spain

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The First 4 Central American Cases Of Delayed Meat Allergy With Galactose-Alpha-1,3-Galactose Positivity Clustered Among Field Biologists In Panama Dr. Paige G. Wickner, MD, Brigham and Women’s Hospital, Division of Rheumatology, Immunology and Allergy, Chesnut Hill, MA and Scott P. Commins, MD, PhD, University of Virginia Health System, Charlottesville, VA Incidence Of New Onset Food Allergy In Renal, Cardiac, and Hepatic Transplant Recipients and Correlation With Immunosuppression Protocol Franc¸ois Graham, MD, MSc1, Frederic Racicot2, Luminita Iuliana Jamali, MD2, Marie-Jeanne Lebel, MD2, Hugo Chapdelaine, MD2, Fernando Alvarez, MD2, Veronique Phan Cong, MD2, Marie-Josee Raboisson, MD2, Louis P. Paradis, MD FRCPC FAAAAI2 and Anne M. Des Roches, MD FRCPC FAAAAI2, 1 CHUM, H^ opital Notre-Dame, Montreal, QC, Canada, 2Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada Late and Secondary Onset Food Allergy Dr. Liat Nachshon, MD1, Dr. Michael Goldberg, MD, PhD1, Dr. Arnon Elizur, MD1,2, Dr. Michael B. Levy, MD, FAAAAI1 and Prof. Yitzhak Katz, MD, FAAAAI1,2, 1Assaf Harofeh, Zerifin, Israel, 2Tel Aviv University, Tel Aviv, Israel Food Allergy Testing Practices Of Primary Care Pediatricians In Illinois Hector Rodriguez, MD1,2, Ms. Claudia Lau1, Dr. Ruchi Gupta, MD, MPH1,2 and Melanie M. Makhija, MD1,3, 1Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 2Northwestern University Feinberg School of Medicine, Chicago, IL, 3Division of Allergy & Immunology, Department of Pediatrics,Northwestern University Feinberg School of Medicine, Chicago, IL Understanding The Role Of Online Resources For Childhood Food Allergies David Goese, University of Chicago Pritzker School of Medicine, Chicago, IL and Ves Dimov, MD, University of Chicago Medicine, Chicago, IL; Section of Allergy, Asthma and Immunology, Department of Pediatrics, Department of Medicine, University of Chicago, Chicago, IL Clinical Features, Diagnosis, Management and Natural History Of Food Protein-Induced Enterocolitis Syndrome In a National Cohort Dr. Todd David Green, MD, FAAAAI1, Dr. Matthew J. Greenhawt, MD, MBA, MSc2, Dr. Tammy S. Jacobs, MD, MA1 and Fallon Schultz3, 1Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 2Department of Internal Medicine, The University of Michigan Medical School, Division of Allergy and Clinical Immunology, Ann Arbor, MI, 3International Association for Food Protein Enterocolitis (IAFFPE)

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Health Literacy Is Associated With Medication Adherence In Adolescents and Young Adults With HIV-1 Infection Dr. Amrita Khokhar, MD, Department of Medicine, Hofstra North Shore-LIJ School of Medicine, Dr. Robert Sporter, MD, Division of Allergy/Immunology, Departments of Medicine and Pediatrics, Hofstra North Shore-LIJ School of Medicine, Kathryn Kilkenny, Division of Allergy/Immunology, Departments of Medicine and Pediatrics, Hofstra North Shore-LIJ School of Medicine and Dr. David Rosenthal, DO, Division of Allergy/Immunology, Departments of Medicine and Pediatrics, Hofstra North Shore-LIJ School of Medicine, Great Neck, NY

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Variability In Measurement Of Allergen Skin Testing Results Among Allergy-Immunology Specialists Dr. Tiffany Jean1, Dr. Kenny Y. Kwong1 and Dr. Nasser Redjal, MD, FAAAAI2, 1Harbor-UCLA Medical Center, 2Harbor-UCLA Medical Center, Torrance, CA Serologic Specific IgE (sIgE) Testing In a Closed Healthcare System Dr. Daniel A. Steigelman, MD and Dr. Tonya S. Rans, MD, Wilford Hall Ambulatory Surgical Center, Joint Base San Antonio Lackland AFB, TX Outcomes After Implementation Of An Inpatient Antibiotic Prescribing Pathway For Patients With Penicillin Or Cephalosporin Allergy Dr. Kimberly Blumenthal, MD, Allergy and Immunology, Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, Dr. Erica Shenoy, MD, PhD, Division of Infectious Disease and Infection Control Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, Ms. Christy Varughese, Pharm.D., Department of Pharmacy, Infection Control Unit, Massachusetts General Hospital, Boston, MA, Dr. David Hooper, MD, PhD, Division of Infectious Disease and Infection Control Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA and Dr. Aleena Banerji, MD, Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA The Effect Of Panel Ordering On Utilization Of In Vitro Specific IgE Testing By Primary Care Physicians In a Large HMO Dr. Bruce J. Goldberg, MD, PhD, FAAAAI, Kaiser Permanente, Los Angeles, CA and Dr. John S. Kaptein, PhD, Southern California Permanente Medical Group, Los Angeles, CA Premature Discontinuation Of Allergy Immunotherapy-Inadequate Reimbursement By Health Insurers A Major Factor Dr. Surender K. Vaswani, MD, FAAAAI, Allergy & Asthma Clinical Center, Columbia, MD, Ravi Vaswani, New York University School of Medicine, Dr. Njideka Udochi, Howard County General Hospital/Johns Hopkins, Rajiv Karani, University of Cincinnati School of Medicine and Dr. Leena Parikh, St.Agnes Hospital Adherence To Labeling Guidelines Of Inhalant Allergen Immunotherapy Practice Parameter 2011 At The University Of Michigan Health Service Dr. Marilyn Karam, MD1, Kiela Samuels2, Cynthia Hernandez, RN2, Dr. Christine L. Holland, MD1 and Dr. Matthew J. Greenhawt, MD, MBA, MSc3, 1The University of Michigan, Division of Allergy and Clinical Immunology, Ann Arbor, MI, 2University of Michigan Health System, Ann Arbor, MI, 3Department of Internal Medicine, The University of Michigan Medical School, Division of Allergy and Clinical Immunology, Ann Arbor, MI The Prevalence Of Allergic Rhinitis Among High- School Male Military Recruits In Jordan Dr. Mansour Fuad Karadsheh, MD and Dr. Suleiman Soudi, Royal Medical Services, Madaba, Jordan Allergen Sensitivity Patterns Among Atopic Individuals At A Tertiary Allergy Center Dr. Lukena U. Karkhanis, MD, Dr. Sarena Sawlani, MD and Dr. Andrew Kau, MD, PhD, Washington University School of Medicine, St. Louis, MO Assessing Quality Of Life In Patients With AERD After Aspirin Desensitization Dr. Melissa Iammatteo, MD1, Dr. Autumn Chandler Guyer, MD2, Dr. Rebecca Saff, MD, PhD3, Dr. Eric Holbrook, MD4, Dr. Stacey Gray, MD4, Dr. Aidan Long, MD, FAAAAI5 and Dr. Aleena Banerji, MD5, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Harvard Medical School, Boston, MA, 3 Allergy and Clinical Immunology, Massachusetts General Hospital, Boston, MA, 4Massachusetts Eye and Ear Infirmary, Boston,

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MA, 5Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA Published Findings On Dust Allergens May Be Inaccurate Due To Improper Handling Of Values Below The Lower Limit Of Detection Henry Lynn, Mr. Agustin Calatroni, MA MS, Katy Jaffee, MS, Rebecca A. Zabel and Samuel J. Arbes Jr., Rho, Inc., Chapel Hill, NC Patient-Reported Factors That Influence Diphenhydramine Use In Children and Adults In An Allergy Specialty Practice Dr. Prakash Navaratnam1, Dr. Robert Anolik, MD, FAAAAI2, Dr. Howard Friedman, MS, PhD1 and Dr. Eduardo Urdaneta, MD3, 1 DataMed Solutions LLC, New York, NY, 2Allergy and Asthma Specialists, PC, Blue Bell, PA, 3McNeil Consumer Healthcare, Fort Washington, PA

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Allergen Extracts and Immunotherapy 4210 Monday, March 3rd, 2014, 9:45 AM - 10:45 AM 754

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The Efficacy and Safety Of The Short Ragweed Sublingual Immunotherapy Tablet MK-3641 Is Similar In Asthmatic and Nonasthmatic Subjects Treated For Allergic Rhinitis With/ Without Conjunctivitis (AR/C) Dr. Jennifer Maloney, MD1, Dr. David I. Bernstein, MD, FAAAAI2, Dr. Jacques H!ebert, MD3, Dr. Martha White, MD4, Dr. Robert Fisher, MD5, Dr. Thomas B. Casale, MD, FAAAAI6, Dr. Amarjot Kaur, PhD1 and Dr. Hendrik Nolte, MD, PhD1, 1Merck, Whitehouse Station, NJ, 2Bernstein Allergy Group, Cincinnati, OH, 3Centre de Recherche Appliqu!ee en Allergie de Qu!ebec, Qu!ebec City, QC, Canada, 4Institute for Asthma & Allergy, Wheaton, MD, 5Allergy Research & Care, Milwaukee, WI, 6Univeristy Of South Florida Morsani College Of Medicine, Tampa, FL Compliance With Guidelines In The Use Of Allergen Immunotherapy Dr. Pudupakkam K Vedanthan, MD1, Ms. Christina Cutter, MSc, BA2, Ms. Phuong Dinh, BS2 and Mr. Peter DeWitt, MS2, 1University of Colorado, Lakewood, CO, 2University of Colorado - Anschutz Medical Campus, Aurora, CO Efficacy Of Short Ragweed Sublingual Immunotherapy Tablet (SLIT-T) In Mono-Sensitized and Poly-Sensitized Subjects Dr. David I. Bernstein, MD, FAAAAI1, Kevin R. Murphy, MD2, Dr. Hendrik Nolte, MD, PhD3, Dr. Amarjot Kaur, PhD3 and Dr. Jennifer Maloney, MD3, 1Bernstein Allergy Group, Cincinnati, OH, 2 Boys Town National Research Hospital, Boys Town, NE, 3Merck, Whitehouse Station, NJ Trends In Prescribing Of Specific Immunotherapy For Grass Pollen Allergy In Germany: 2005-2012 Prof. Ulrich Wahn, Prof Dr Med1, Amanda McDonnell2, Catrina Richards2, Dr. Felicia C. Allen-Ramey, PhD3, Mr. Jakob N. Andreasen4, Charles Hawes2 and Dirk Demuth2, 1Charite, Berlin, Germany, 2IMSHealth, United Kingdom, 3Merck & Co, Inc, West Point, PA, 4ALK, Denmark Efficacy Of 300IR 5-Grass Pollen Sublingual Tablets In The Treatment Of Rhinitis Symptoms In Patients With Grass Pollen-Induced Allergic Rhinoconjunctivitis Prof. Claus Bachert, MD, PhD1, Prof. Alain Didier, MD, PhD2, Ms. Laurence Ambroisine, Msc3, Dr. Kathy Abiteboul, PharmD3 and Dr. Robert K. Zeldin, MD3, 1Universitair Ziekenhuis Gent, Ghent, Belgium, 2Larrey Hospital, CHU, Toulouse, France, 3Stallergenes S.A., Antony, France Allergen Immunotherapy Safety While Using ‘‘High Risk’’ Medication: A Survey Of AAAAI Members Dr. Matthew A. Rank, MD, FAAAAI, Mayo Clinic, Scottsdale,

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AZ, Dr. David W. Hauswirth, MD, FAAAAI, Nationwide Children’s Hospital, Columbus, OH, Dr. Christopher W. Calabria, MD, Dilley Allergy and Asthma Specialists, San Antonio, TX, Dr. Lawrence D. Sher, MD, FAAAAI, Peninsula Research Associates, Rolling Hills Estates, CA and Dr. D!esir!ee E.S. Larenas Linnemann, MD, FAAAAI, Hospital Medica Sur, Mexico D.F., Mexico Venom Immunotherapy Use With Contraindicated Medication: A Survey Of AAAAI Member’s Experience Dr. David W. Hauswirth, MD, FAAAAI, Buckeye Allergy, Columbus, OH; Nationwide Children’s Hospital, Columbus, OH, Dr. Matthew A. Rank, MD, FAAAAI, Mayo Clinic, Scottsdale, AZ, Dr. D!esir!ee E.S. Larenas Linnemann, MD, FAAAAI, Hospital Medica Sur, Mexico D.F., Mexico, Dr. Lawrence D. Sher, MD, FAAAAI, Peninsula Research Associates, Rolling Hills Estates, CA and Dr. Christopher W. Calabria, MD, Dilley Allergy and Asthma Specialists, San Antonio, TX Simultaneous Measurement Of Multiple Proteins In Blattella Germanica Extract Using Antibody-Based Multiplex Assay Dr. Taruna Khurana, PhD1, Ms. Maggie Collison1 and Dr. Jay E. Slater, MD2, 1CBER FDA, 2FDA/CBER/OVRR/DBPAP, Rockville, MD Characterization and Protein Composition Of Food Allergen Extracts Dr. Greg A. Plunkett, PhD and Dr. Tricia Moore, PhD, ALKAbell! o, Inc, Round Rock, TX Stability and Compatibility Of Cat, Dog, Dust Mite, and Cockroach Extracts In Indoor Allergen Mixtures and Dilutions For Immunotherapy Dr. Silvia Huebner, MD1, Dr. Satyen Manilal Gada, MD2, Dawn Hall, BS3 and Dr. Thomas Grier, MD3, 1Evans Army Community Hospital, Fort Carson, CO, 2Walter Reed National Military Medical Center, Bethesda, MD, 3Greer Labs Interest Of Mass Spectrometry-Based Quantification Of Relevant Allergens To Improve The Standardization Of Allergen Extracts Thierry Batard, PhD1, Emmanuel Nony2, Christel Dayang, PhD2, Julien Bouley, PhD2, Maxime Le Mignon, PhD2, Christelle Berrouet2, Aur!elie Lautrette, PhD2, Marie Naveau, PhD2, Henri Chabre, PhD2 and Dr. Philippe Moingeon, PhD3, 1Stallergenes, Antony, France, 2Stallergenes, France, 3Stallergenes SA, Antony, France

Outcome Measures and Challenge Testing with Immunotherapy 4211 Monday, March 3rd, 2014, 9:45 AM - 10:45 AM 765

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Baseline Predictors Of Symptom Severity Following Exposure To House Dust Mite In An Antigen Challenge Chamber (ACC) Daniel Ramirez, MD1, Robert L. Jacobs, MD1, Cynthia Rather, CCRC1, Andrew Carrillo, BS2,3, Weijing He, MD2,3, Nathan Harper, BS2,3, Charles Andrews, MD1 and Sunil K. Ahuja, MD2,3, 1Biogenics Research Chamber, San Antonio, TX, 2Department of Medicine, University of Texas Health Science Center, San Antonio, TX, 3Veterans Administration Center for Personalized Medicine, South Texas Veterans Health Care System, San Antonio, TX Validation Of Biogenics Research Chamber For Elicitation Of Symptoms To Dust Mite Antigen (Der p1) Robert L. Jacobs, MD1, Cynthia Rather, CCRC1, Fabio Jimenez, BS2,3, Hernan Martinez, MD2,3, Weijing He, MD2,3, Daniel Ramirez, MD1, Charles Andrews, MD1 and Sunil K. Ahuja, MD2,3, 1Biogenics Research Chamber, San Antonio, TX, 2Department of Medicine, University of Texas Health Science Center, San Antonio,

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J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

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Tcheurekdjian, MD, FAAAAI4, 1University Hospitals, South Euclid, OH, 2Rainbow Babies and Children’s Hospital, Cleveland, OH, 3Case Western Reserve University School of Medicine, Cleveland, OH, 4Allergy/Immunology Associates, Inc., South Euclid, OH

Mechanistic Insight into Pollens and Other Antigens 4212 Monday, March 3rd, 2014, 9:45 AM - 10:45 AM 775

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Protease Inhibitor Reduces Airway Response and Inflammation In Mouse Model Of Cockroach Allergy Mr. Sanjay Saw, M.Sc. and Dr. Naveen Arora, Ph.D, CSIR Institute of Genomics and Integrative Biology, New Delhi, India Aryl Hydrocarbon Receptor (AhR) Modulates Cockroach Allergen Induced TGF Beta 1 Secretion In Fibroblasts Sarah Mirza1,2, Yufeng Zhou, MD, PhD1, Priya Tripathi, PhD1, Liang Yuan1, Beverly Plunkett, MS1, Allen Myers, Ph.D1 and Peisong Gao, MD, PhD1, 1Division of Allergy & Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, 2 Sher-I-Kashmir Institute of Medical Sciences, Jammu and Kashmir, India Effect Of Peanut Allergens On Intestinal Barrier Permeability and Tight Junction Localisation In Caco-2 Cell Cultures Prof. Cenk Suphioglu, PhD1, Ms. Dwan Price, BSc Hons1, Prof. Leigh Ackland, PhD2, A. Wesley Burks, MD, FAAAAI3 and Dr. Matthew Knight, PhD4, 1Deakin University, Australia, 2Deakin Universisty, Australia, 3University of North Carolina, Chapel Hill, NC, 4Department of Primary Industries, Australia Synergistic Effect Of Dermatophagoides Pteronyssinus Allergens and Dexamethasone On Expression Of CD163 By Peripheral Blood Mononuclear Cells Of Allergic Asthma Patients Prof. Krzysztof Kowal, MD, PhD1, Pawel Bernatowicz, MD, PhD2, Prof. Lech Chyczewski, MD, PhD2 and Prof. Anna Bodzenta-Lukaszyk, MD, PhD3, 1Medical University of Bialystok, Bialystok, Poland, 2Medical University of Bialystok, 3Medical University of Bialystok, Poland IgE Antibodies and FceRI Are Critical For Acquired Resistance Against Honeybee Venom In Mice Dr. Philipp Starkl, PhD1, Dr. Thomas Marichal, DVM PhD1, Dr. Laurent L. Reber, PhD1, Dr. Janet Kalesnikoff, PhD1, Dr. Hans C. Oettgen, MD, PhD, FAAAAI2, Dr. Martin Metz, MD, PhD3 and Dr. Stephen J. Galli, MD1, 1Stanford University School of Medicine, Stanford, CA, 2Boston Children’s Hospital, Boston, MA, 3 Charite Campus Mitte, Berlin, Germany Ragweed Pollen Proteins Bind TLR4/MD2, and Rapidly Recruit MyD88 and TRAF6 To The Signaling Complex Dr. Qian Sun, PhD, Dr. Koa Hosoki, MD, PhD, Dr. Leopoldo Aguilera-Aguirre, PhD, Prof. Istvan Boldogh, PhD and Prof. Sanjiv Sur, MD, University of Texas Medical Branch, Galveston, TX Sensitization To Silkworm Moth (Bombyx mori) Allergen In Patients With Respiratory Allergy Mrs. Laura ML Araujo, Federal University of Parana, Brazil and Prof. Nelson A. Rosario, MD, PhD, FAAAAI, Federal University of Parana, Curitiba, Brazil Balsam Of Peru, a Common Contact Dermatitis Allergen, Is a CD1a Antigen Sarah Nicolai, MD1,2, Tan-Yun Cheng, PhD1,2, Elvire A. Bourgeois, PhD1,2, Annemieke de Jong, PhD3 and D. Branch Moody, MD1,2, 1Brigham and Women’s Hospital, Division of Rheumatology, Immunology and Allergy, Boston, MA, 2Harvard Medical School, Boston, MA, 3Columbia University Medical Center, Department of Dermatology, New York, NY

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TX, 3Veterans Administration Center for Personalized Medicine, South Texas Veterans Health Care System, San Antonio, TX Magnitude Of Changes In Patient Symptom and Medication Scores In Grass Allergy Immunotherapy Trials: Dependency On Levels Of Pollen Exposure Dr. Hendrik Nolte, MD, PhD1, Prof. Stephen R. Durham, MA MD FRCP2, Dr. Harold S. Nelson, MD, FAAAAI3, Dr. David I. Bernstein, MD, FAAAAI4, Dr. Peter S. Creticos, MD, FAAAAI5, Dr. Ziliang Li, PhD1 and Dr. Jens Andersen, PhD6, 1 Merck, Whitehouse Station, NJ, 2Imperial College London, London, United Kingdom, 3National Jewish Health, Denver, CO, 4 Bernstein Allergy Group, Cincinnati, OH, 5Johns Hopkins Division of Allergy & Clinical Immunology, 6ALK-Abello, Hørsholm, Denmark Evaluation Of Acoustic Rhinometry In Histamine Nasal Provocation Test In Children and Adolescents Dr. Fausto Y. Matsumoto, Federal University of S~ao Paulo, S~ao Paulo, Brazil, Dr. Gustavo Wandalsen, MD, UNIFESP, Sao Paulo, Brazil, Dr. Aline Mendes, Federal University of S~ao Paulo, Brazil. and Prof. Dirceu Sole, MD, PhD, Federal University of Sao Paulo, Sao Paulo, Brazil EQ-5D Health Utility Values In The Treatment Of Seasonal Grass Pollen Induced Rhinoconjunctivitis Mr. Jakob N. Andreasen1, Dr. Chris Poole2, Dr. Christian Bannister3, Dr. Jens Andersen, PhD4 and Mr. Niels Serup-Hansen1, 1ALK, Denmark, 2Cardiff University, Cardiff, Wales, 3Cardiff University, 4 ALK-Abello, Hørsholm, Denmark Ex-Vivo Allergen Stimulation In Whole Blood: A Novel Approach For Evaluating Mechanisms Of Action Of Synthetic Peptide Immuno-Regulatory Epitopes Dr. Pascal LC Hickey, BPharm PhD1, Dr. Mark Larche, PhD2, Dr. Rod Hafner, PhD3, Ms. Kristen Armstrong, M.Sc.4, Ms. Eileen Lee, BA (Hons)5, Dr. Elaine Lee, PhD5 and Dr. Stephen A. Kilfeather, PhD5, 1Adiga Life Sciences, Hamilton, Canada, 2McMaster University, Hamilton, ON, Canada, 3Circassia Ltd, Oxford, United Kingdom, 4Adiga Life Sciences Inc., Hamilton, ON, Canada, 5Aeirtec Limited, Newcastle upon Tyne, United Kingdom Efficacy Of 300IR 5-Grass Pollen Sublingual Tablets In Grass Pollen-Induced Allergic Rhinoconjunctivitis: Pooled Analysis By Age Dr. Robert K. Zeldin, MD1, Prof. Ulrich Wahn, Prof Dr Med2, Prof. Alain Didier, MD, PhD3, Mrs. Armelle Montagut1 and Dr. Marie-Pierre Furrer, PhD1, 1Stallergenes S.A., Antony, France, 2 Charite, Berlin, Germany, 3Larrey Hospital, CHU, Toulouse, France Characterization Of Allergic Rhinitis Symptomotology Induced By a Nasal Allergen Challenge (NAC) Titration In a Dust Mite Sensitize Population Mr. Paul Gomes1, Endri Angjeli2, Mr. Keith Lane2 and Dr. Paul H. Ratner, MD, FAAAAI3, 1ORA. Inc, Andover, MA, 2Ora, Inc, Andover, MA, 3Sylvana Research, San Antonio, TX Atopic and Non-Atopic Individuals Manifest Partly Concordant Clinical and Leukocyte Responses Following Exposure To House Dust Mite In An Antigen Challenge Chamber (ACC) Weijing He, MD1,2, Nathan Harper, BS1,2, Andrew Carrillo, BS1,2, Charles Andrews, MD3, Cynthia Rather, CCRC3, Daniel Ramirez, MD3, Robert L. Jacobs, MD3 and Sunil K. Ahuja, MD1,2, 1Department of Medicine, University of Texas Health Science Center, San Antonio, TX, 2Veterans Administration Center for Personalized Medicine, South Texas Veterans Health Care System, San Antonio, TX, 3Biogenics Research Chamber, San Antonio, TX The Effects Of Pollen Season On Reactions To Subcutaneous Immunotherapy Dr. Devi Jhaveri, DO1, Dr. Julie Abraham, M.D.2, Megan Betteley, B.S.3, Dr. Mary Ann O’Riordan, PhD2, Dr. Theodore H. Sher, MD, FAAAAI4, Dr. Robert W. Hostoffer, DO4 and Dr. Haig

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Cellular Infiltrate Induced By Bites From The Tick Amblyomma Americanum In Subjects With Or Without IgE To Galactose-Alpha-1,3-Galactose (Alpha-gal) Dr. Nikhila Schroeder, MD1, Mr. Jake Eccles2, Erin J. Klaffky, MD, PhD1 and Thomas A.E. Platts-Mills, MD, PhD, FAAAAI1, 1 Division of Asthma, Allergy & Immunology, University of Virginia Health System, 2University of Virginia School of Medicine Duox2 and Mitochondria-Induced Antiviral Innate Immune Response After Influenza A Virus Infection In Human Nasal Epithelium Prof. Hyun Jik Kim1,2, Prof. Chang-Hoon Kim3,4, Dr. Sung-Shik Kim5 and Prof. Joo-Heon Yoon3,6, 1Chung-Ang University College of Medicine, Seoul, South Korea, 2Airway Mucus Institute, Seoul, South Korea, 3Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea, 4The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, South Korea, 5Koenko Nose Infirmary, Seongnam, South Korea, 6Research Center for Human Natural Defense System, Yonsei University College of Medicine, Seoul, South Korea Persistent Endothelial Damage After Intravenous Immunoglobulin Therapy In Kawasaki Disease Dr. Yoshihiko Sakurai1,2, Dr. Hideo Takatsuka1, Dr. Mutsuzo Takada1 and Dr. Masato Nishino1, 1Nara Prefectural Mimuro Hospital, Sango, Japan, 2Matsubara Tokushukai Hospital, Matsubara, Japan Prevalence Of Toxocariasis In General Population Based On Serologic Test Prof. Byung-Jae Lee, MD1, Dr. Jin-Young Lee, MD1, Dr. Mi-Jung Oh, MD2 and Prof. Dong-Chull Choi, MD1, 1Samsung Medical Center, 2Bundang Jesaeng General Hospital Vitamin D Levels and Sensitization To Indoor Inhalant Allergens In Korea Dr. Kyung-Hwan Lim1,2, Dr. Min-Gyu Kang1,2, Dr. Han-Ki Park1, Prof. So-Hee Lee1, Prof. Min-Suk Yang1,3, Prof. Woo-Jung Song, M.D.1, Prof. Hye-Ryun Kang1, Prof. Heung-Woo Park, MD, PhD1, Prof. Sun-Sin Kim1, Prof. Yoon-Seok Chang1,2, Prof. Sang Heon Cho, MD, PhD1, Prof. Kyung-Up Min, MD, PhD1 and Prof. Sae-Hoon Kim1,2, 1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, 2Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea, 3SMG-SNU Boramae Medical Center, Seoul, South Korea Measuring Vascular Leak During Respiratory Viral Infections Dr. Brian T. Kelly, MD, Mrs. Desire Hunter and Dr. Mitchell H. Grayson, MD, FAAAAI, Medical College of Wisconsin, Milwaukee, WI Effects Of Rhinovirus (RV) 39 Infection On Airway Hyper-Reactivity (AHR) To Histamine and Carbachol In Human Airways Joshua L. Kennedy, MD1, Stacie M. Jones, MD1,2, Ms. Megan Kurten1,3, Ms. Suzanne House1,3 and Richard Kurten, PhD1,3, 1Arkansas Children’s Hospital Research Institute, Little Rock, AR, 2 University of Arkansas for Medical Sciences and Arkansas Children’s Hospital, Little Rock, AR, 3University of Arkansas for Medical Sciences, Little Rock, AR

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Bone Marrow Transplantation in Primary Immunodeficiencies 4602 Monday, March 3rd, 2014, 2:00 PM - 3:15 PM 795

Adherence 4601 Monday, March 3rd, 2014, 2:00 PM - 3:15 PM 790

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Poor Asthma Control In Older Adults Is Associated With Reduced Adherence To Controller Therapies and Inability To Afford Medications Dr. Jessica Tan, MD, MPH1, Dr. David I. Bernstein, MD, FAAAAI2, Ms. Cheryl Koff Bernstein, RN BSN CCRC3, Dr. Patrick Ryan, PhD4, Dr. Jonathan A. Bernstein, MD, FAAAAI5, Ms. Banu Kesavalu6, Dr. Manuel S. Villareal, MD, FAAAAI1,7, Dr.

Andrew M. Smith, MD, FAAAAI8, Dr. Peter Lenz9 and Dr. Tolly Epstein, MD, MS10, 1University of Cincinnati Medical Center, Cincinnati, OH, 2Bernstein Allergy Group, Cincinnati, OH, 3Bernstein Clinical Research Center, LLC, Cincinnati, OH, 4Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 5Division of Immunology Allergy & Rheumatology, University of Cincinnati Medical Center, Cincinnati, OH, 6University of Cincinnati, 7University of Cincinnati, Cincinnati, OH, 83255 Eden Ave., HPB 350, University of Cincinnati Medical Center, Cincinnati, OH, 9 The University of Cincinnati Medical Center, 10Allergy Partners of Central Indiana, Indianapolis, IN Texting Medication Reminders For Better Asthma Control In Children and Teens Dr. Humaa M. Bhatti, DO1, Ms. Wafa Alame, RN1, Mr. Joseph Adams2, Dr. Jenny M. Montejo, MD1, Dr. Milind V. Pansare, MD, FAAAAI1, Dr. Pavadee Poowuttikul, MD1 and Dr. Elizabeth A. Secord, MD, FAAAAI2, 1Children’s Hospital of Michigan, Detroit, MI, 2Wayne State University, Detroit, MI Adherence To Prescribed Controller Therapy and Effects On Asthma Control In The Hispanic Population Of a Pediatric Disease Management Program Dr. Lyne G. Scott, MD1, Tricia Morphew2, Marilyn Li1 and Dr. Salima A. Thobani, MD1, 1University of Southern California, 2 Morphew Consulting, LLC, CA Correlation Between Emergency Department Visits For Asthma Exacerbation and No Show Visits To Primary Care Provider In a Pediatric Population Dr. Margaret Redmond, M.D. and David R. Stukus, MD, FAAAAI, Nationwide Children’s Hospital, Columbus, OH Choosing Wisely: Adherence By Allergists To Recommended Use Of Spirometry In The Diagnosis and Management Of Adult Asthma Dr. Kristin C. Sokol, MD, MPH, Dr. Gregg Wilkinson, PhD, Ms. Karen Pierson, MA and Dr. Randall M. Goldblum, MD, University of Texas Medical Branch, Galveston, TX

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G Protein-Coupled Receptor Kinase-3 (GRK-3) In Bone Marrow Niche Interactions and Transplantation Jaime M. Brozowski1,2, Roman Timoshchenko2, Jessica Koontz3, Janet Rubin3,4, Matthew Billard2 and Teresa K. Tarrant2,3, 1Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA, 2Thurston Arthritis Research Center and Department of Medicine, Division of Rheumatology, Allergy, and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA, 3School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA, 4Pediatrics and Pharmacology and Department of Medicine, Division of Endocrinology and Metabolism, University of North Carolina, Chapel Hill, NC 27599, USA Allogeneic Hematopoietic Stem Cell Transplantation For Immune Dysregulation, Polyendocrinopathy, X-Linked (IPEX) Syndrome Resolves Enteropathy and Autoimmunity: A Single Institution Experience Dr. Zeynep Yesim Yesim Kucuk, MD, Dr. Jack J.H. Bleesing, MD, PhD, Dr. Rebecca A. Marsh, MD, Dr. Kejian Zhang, MD, Dr. Stella Davies, MBBS, PhD and Dr. Alexandra H. Filipovich, MD, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

Abstracts AB347

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

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Natural Killer Cell Immunoglobulin Like Receptor (KIR) Genetic Profile Is a Strong Predictor Of Allogeneic Hematopoietic Cell Transplant Outcomes Dr. Rehan M. Faridi, PhD1, Taylor Kemp1, Dr. Poonam Dharmani, PhD1, Dr. Victor Lewis, MD2, Dr. Noureddine Berka, PhD3, Dr. Jan Storek, MD, PhD1 and Dr. Faisal Khan, PhD1, 1University of Calgary, Calgary, AB, Canada, 2Alberta Children’s Hospital, Calgary, AB, Canada, 3Calgary Laboratory Services, Calgary, AB, Canada Transient Lymphopenia Of Infancy: A Previously Unrecognized Entity Dr. Robert Sporter, MD, Division of Allergy/Immunology, Departments of Medicine and Pediatrics, Hofstra North Shore-LIJ School of Medicine, Dr. Catherine Capo, MD, Department of Medicine, Hofstra North Shore-LIJ School of Medicine, Manhasset, NY and Dr. Vincent R. Bonagura, MD, FAAAAI, Division of Allergy/ Immunology, Departments of Medicine and Pediatrics, Hofstra North Shore-LIJ School of Medicine, Great Neck, NY

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FAAAAI3, 1Department of Pediatric Allergy and Immunology, Stanford University, Stanford, CA, 2Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, 3Pediatric Allergy Immunology, Stanford University, Stanford, CA Impact Of BMI On Ozone-Induced IL-1b In The Airways Of Human Volunteers Dr. Michelle L. Hernandez, MD1, Dr. Krista Todoric, MD1, Ms. Katherine Mills, BA2, Dr. Haibo Zhou, PhD3 and Dr. David B. Peden, MD, MS, FAAAAI4, 1University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 2University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC, 3University of North Carolina at Chapel Hill, School of Public Health, 4 Office #544, Campus Box 7310, University of North Carolina at Chapel Hill School Medicine, NC Group-2 Innate Lymphoid Cells Promote Air-Pollutant Induced Airway Inflammation and Hyperresponsiveness (AHR) Dr. Qi Yang, PhD, Moyar Q. Ge, Blerina Kokalari, Imre G Redai, Xinxin Wang, Dr. Avinash Bhandoola, MBBS PhD and Dr. Angela Haczku, MD, PhD, FAAAAI, University of Pennsylvania, Philadelphia, PA

Air Pollution/Allergens/Air Quality 4603 Monday, March 3rd, 2014, 2:00 PM - 3:15 PM

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Associations Among Volatile Organic Compounds, Allergic Sensitization, and Respiratory Illness In Children With Asthma Enrolled In a Study Of Low-Income, Green Eco-Friendly Housing (The Green Housing Study) Dr. Joy Hsu, MD, MSCI1, Sandra Chaves, MD, MSc2, Marika Iwane, PhD, MPH2, Yang Qiu, ScM3, Christopher Schaffer, BS4, Marty Alvarez-Reeves, MS3, Prof. Tiina Reponen, PhD4, Dr. Gary Adamkiewicz, PhD3, Dr. Patrick Ryan, PhD5, Doug Brugge, PhD6, David Turcotte, ScD7, Fuyuen Yip, PhD, MPH8, Kanta Sircar, PhD, MPH8, Benjamin Blount, PhD9, K. Udeni Alwis, PhD9, Connie Sosnoff, MA9, Peter Ashley, DrPH10, Curtis Hedman, PhD11, Steve Strebel, BS11, Behrooz Behbod, MBChB, MSc, ScD1, Matthew Lozier, PhD, MPH1 and Dr. Ginger L. Chew, ScD, MSPH8, 1Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, 2National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, 3Harvard School of Public Health, Boston, MA, 4University of Cincinnati, Cincinnati, OH, 5Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 6Tufts University Health Sciences, Boston, MA, 7Center for Family, Work and Community, University of Massachusetts Lowell, Lowell, MA, 8Air Pollution and Respiratory Health Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, 9 Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, 10Office of Healthy Homes and Lead Hazard Control, U.S. Department of Housing and Urban Development, Washington, DC, 11 Wisconsin State Lab of Hygiene, Madison, WI A Systematic Analysis Of Pollen Transcriptomes From Plant Allergens Reveals Conserved Targets Of Immune Responses Dr. Bjoern Peters1, Dr. Jason Greenbaum1, Dr. Veronique M. Schulten1, Dr. Denise Baker1, Dr. April Frazier1, Dr. Alessandro Sette, Dr. Biol. Sci.1, Dr. Michael Wallner 2 and Mrs. Heidi Hofer2, 1 La Jolla Institute for Allergy and Immunology, La Jolla, CA, 2University of Salzburg, Salzburg, Austria Urinary Polycyclic Aromatic Hydrocarbon Metabolites and Th2 Immunity In Children Kinjal M. Hew, PhD1, Annett I. Walker, MD1, Arunima Kohli1, Aleena Syed1, Cameron McDonald-Hyman1, Zheng Li, PhD, MPH2, Andreas Sjodin, PhD2 and Dr. Kari C. Nadeau, MD, PhD,

4604 Monday, March 3rd, 2014, 2:00 PM - 3:15 PM 804

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Peanut T Cell Epitope Discovery: Ara h1 and Ara h3 Dr. Manish Ramesh, MD, PhD1, Madhan Masilamani, PhD2, Dr. George N. Konstantinou, MD, PhD, MSc3,4, Jay A. Lieberman, MD5, Hugh A. Sampson, MD, FAAAAI6, Dr. Madhundra Sivakumar1, Dr. Araya Yuenyongviwat, MD7 and Dr. Mariona Pascal, PhD8, 1Mount Sinai School of Medicine, New York, NY, 2Icahn School of Medicine at Mount Sinai, New York, NY, 3424 General Military Training Hospital, Thessaloniki, Greece, 4First Pediatric Department, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece, 5University of Tennessee, Memphis, TN, 6Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 7Prince of Songkla University, Songkhla, Thailand, 8Servei d’Immunologia, Centre de Diagnostic Biomedic. Hospital Clinic., Barcelona, Spain Microparticles Encapsulated With Antigen Protect Against Sensitization and Reduce Anaphylactic Reactivity In a Food Allergy Model Dr. Karen B. Chien, PhD, Northwestern University, Chicago, IL and Dr. Paul Bryce, PhD, Division of Allergy-Immunology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL Over-The-Counter Dietary Supplements Genistein and Ipriflavone Suppress Peanut Allergy Symptoms Ms. Lisa Chang, BS1, Ms. Mohanapriya Kamalakannan, MS1, Mr. Matthew Stadler1, Hugh A. Sampson, MD, FAAAAI2 and Madhan Masilamani, PhD1, 1Icahn School of Medicine at Mount Sinai, New York, NY, 2Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY Analyzing Casein-Specific IL-4 and IL-13 Secreting T-Cells: A Reliable Tool For Diagnosis Of Cow’s Milk Allergy Dr. Benedicte Michaud, MD, PhD1,2, Dr. Joseph Aroulandom, MD3, Mrs. Nour Ba€ız, PhD4, Dr. Flore Amat, MD3, Dr. Rahel!e Gouvis-Echraghi, MD3, Dr. Sophie Candon, MD, PhD1,2, Mr. Remy Couderc, PhD PharmaD5, Prof. Jean-Francois Bach, MD, PhD1,2, Prof. Lucienne Chatenoud, MD, PhD1,2 and Prof. Jocelyne Just, MD, PhD3,4, 1Universit!e Paris Descartes, Sorbonne Paris Cit!e, France, 2Institut national de la sant!e et de la recherche m!edicale, Unit!e U1013, Paris, France, 3Allergology department, Trousseau

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hospital AP-HP–UPMC Paris 6, France, 4EPidemiology of Allergic and Respiratory diseases (EPAR) Department, UMR-S 707 INSERM, UPMC Paris 6, France, 5Service de Biochimie et Biologie Moleculaire, Trousseau hospital AP-HP, Paris, France Growth Of Children Aged 2-17 With Cow’s Milk, Peanut, and Egg Allergy In NHANES Dr. Karen Robbins, MD1, Robert A. Wood, MD, FAAAAI2 and Corinne Keet, MD, MS2, 1Johns Hopkins University School of Medicine, 2Johns Hopkins University Medical Center, Baltimore, MD

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Allergic Causes Of Death In The United States Dr. Susan J. Kim, MD, Kaiser Permanente Southern California, Los Angeles, CA and Dr. Jordan C. Brooks, PhD, MPH, Life Expectancy Project, San Francisco, CA Death From Anaphylaxis Is a Reassuringly Unusual Outcome Dr. Larry Borish, MD, FAAAAI1, Dr. Theodore Danoff, MD, PhD2 and Dr. Liyuan (Larry) Ma, PhD2, 1Asthma and Allergic Diseases Center, Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, 2Endo Pharmaceuticals Inc. Allergic Rhinitis, Asthma and Cardiovascular Disease Dr. Angelina M. Crans Yoon, MD1, Dr. Anne M. Staveren, MD1, Dr. Michael S. Kaplan, MD, FAAAAI1, Dr. Javed Sheikh, MD, FAAAAI2 and Dr. Bruce J. Goldberg, MD, PhD, FAAAAI1, 1Kaiser Permanente, Los Angeles, CA, 2Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA Pre-Natal and Early Life Predictors Of Atopy In Canadian Children: Results Of The Family Study Tahira Batool, MBBS, FRCPC1, Michael M. Cyr, MD, FRCPC1, Judah Aryeh Denburg, MD, FRCPC, FAAAAI1, Ms. Karleen Schulze, MMath2, Sonia Anand, MD, FRCPC2, Koon Teo, MD, FRCPC2 and Family Investigators2, 1Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, ON, Canada, 2Population Health Research Institute, Department of Medicine, McMaster University, ON, Canada Association Between Antibiotic Treatment In The First Six Months Of Life and Clinical Allergic Outcomes At Ages 2 To 3 Years Kyra Jones, MEd1, Alexandra Sitarik, M.S.1, Ms. Suzanne Havstad, M.A.1, Ganesa Wegienka, PhD1, Dr. Dennis Ownby, M.D. FAAAAI2, Dr. Edward M. Zoratti, MD, FAAAAI3 and Dr. Christine Cole Johnson, PhD MPH FAAAAI1, 1Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, 2Division of Allergy-Immunology and Rheumatology, Georgia Health Sciences University, Augusta, GA, 3Henry Ford Health System, Detroit, MI

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Chronic Rhinosinusitis 4606 Monday, March 3rd, 2014, 2:00 PM - 3:15 PM 814

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The Clinical Significance Of Specific Antibody Deficiency (SAD) Severity In Chronic Rhinosinusitis (CRS) Dr. Anjeni Keswani, MD1, Neha Mehrotra, MD2, Dr. Angelica Manzur3, Dr. Rakesh Chandra, MD4, Dr. David Conley, MD5, Dr. Bruce K. Tan, MD5, Dr. Leslie C. Grammer, MD, FAAAAI1, Dr. Robert C. Kern, MD5, Dr. Robert P. Schleimer, PhD FAAAAI6

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and Dr. Anju T. Peters, MD, FAAAAI1, 1Department of Medicine, Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2University of Chicago, IL, 3Department of Medicine, Northwestern University Feinberg School of Medicine, 4Northwestern University, Chicago, IL, 5Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, 6Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL Meta-Analysis Of Gene Expression Microarrays Reveals Novel Biomarkers Consistent With Altered Functionality Of Mucosal Barrier In Patients With Chronic Rhinosinusitis Dr. Sergejs Berdnikovs, PhD1, Dr. Atsushi Kato, PhD2, Mr. James Norton, MS2, Ms. Lydia Suh, BSc2, Dr. Robert C. Kern, MD3, Dr. David Conley, MD3, Dr. Rakesh Chandra, MD4, Dr. Anju T. Peters, MD, FAAAAI2, Dr. Leslie C. Grammer, MD, FAAAAI2, Ms. Kathleen E. Harris, BSc2, Dr. Michael Platt, MD5, Dr. Ralph Metson, MD6 and Dr. Robert P. Schleimer, PhD FAAAAI7, 1Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Department of Medicine, Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, 4Northwestern University, Chicago, IL, 5Department of Otolaryngology, Boston Medical Center, Boston University, Boston, MA, 6Department of Otology and Laryngology, Harvard Medical School, Boston, MA, 7Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL Evidence For Immunoglobulin D In Patients With Chronic Rhinosinusitis Dr. Jin Young Min, MD, PhD1, Dr. Robert C. Kern, MD1, Dr. Kathryn E. Hulse, PhD2, Dr. Rakesh Chandra, MD2, Dr. David Conley, MD1, Ms. Lydia Suh, BSc3, Mr. Roderick Carter, BSc3, Mr. James Norton, MS3, Julia H. Huang1, Dr. Atsushi Kato, PhD3, Dr. Robert P. Schleimer, PhD FAAAAI4 and Dr. Bruce K. Tan, MD1, 1Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2 Northwestern University, Chicago, IL, 3Department of Medicine, Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 4Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL Oncostatin M Is Elevated In Chronic Rhinosinusitis and Decreases Barrier Function In Human Airway Epithelium Ms. Kathryn L. Pothoven1,2, Mr. James Norton, MS2, Dr. Christopher Ocampo, MD, PhD2, Ms. Lydia Suh, BSc2, Mr. Roderick Carter, BSc2, Dr. Kathryn E. Hulse, PhD3, Dr. Sudarshan Seshadri, PhD2, Dr. Bruce K. Tan, MD4, Dr. Rakesh Chandra, MD3, Dr. Anju T. Peters, MD, FAAAAI2, Ms. Kathleen E. Harris, BSc2, Dr. David Conley, MD4, Dr. Leslie C. Grammer, MD, FAAAAI2, Dr. Robert C. Kern, MD4 and Dr. Robert P. Schleimer, PhD FAAAAI5, 1Driskill Graduate Program, Northwestern University, Chicago, IL, 2Department of Medicine, Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Northwestern University, Chicago, IL, 4Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, 5Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL Immunologic Changes During Chronic Rhinosinusitis Exacerbations Compared To Controls Dr. Shefali Samant, MD1, Dr. Matthew A. Rank, MD, FAAAAI2, Dr. John B. Hagan, MD, FAAAAI1, Dr. Erin O’Brien1, Dr. Devyani Lal3 and Hirohito Kita, MD1, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic, Scottsdale, AZ, 3Mayo Clinic, Phoenix, AZ

Mechanisms of Asthma and Allergic Disease 4607 Monday, March 3rd, 2014, 2:00 PM - 3:15 PM 819

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Allergen Challenge Increases Peripheral Blood CD84+ ILC2 In Allergic Rhinitis Dr. David R. Scott, M.D.1, Dr. Taylor A. Doherty, MD, FAAAAI2, Naseem Khorram, M.S.3, Mr. Sean Lund, B.S.3, Ms. Rachel Baum, B.S.3, Jinny Chang, M.D.4, Mr. Peter Rosenthal, B.S.3, Mr. Andrew Beppu, B.S.3, Dr. Marina Miller, MD, PhD3 and Dr. David H. Broide, MB ChB FAAAAI5, 1Allergy and Asthma Center of Western Colorado, 2Medicine, University of California, San Diego, San Diego, CA, 3University of California San Diego, 4Sansum Clinic, Santa Barbara, 5Department of Medicine, San Diego, CA Asthma Susceptibility Due To Environmental Programming Of Innate Immunity In Utero Sarah Manners, BS1, Rafeul Alam, MD, PhD, FAAAAI1, David A. Schwartz, MD2 and Magdalena M. Gorska, MD, PhD1, 1National Jewish Health, Denver, CO, 2University of Colorado Denver School of Medicine, Aurora, CO Rhinovirus Challenge Augments Allergen Responsiveness In Basophils Of Atopic Asthmatics Rachana Agrawal, PhD, Thomas A.E. Platts-Mills, MD, PhD, FAAAAI, Peter W. Heymann, MD and Judith A. Woodfolk, MBChB, PhD, FAAAAI, University of Virginia, Charlottesville, VA Der p 3 Allergen Activated Ano-1 Channel On Afferent Airway Nerves Regulates Th2 Cell Responses Mr. Mayur Patil, MS1, Dr. Edward G. Brooks, MD2, Dr. Michael Henry, D.D.S, PhD1 and Dr. Armen Akopian, PhD3, 1UTHSCSA, san antonio, TX, 2Univ. Texas Health Science Center San Antonio, San Antonio, TX, 3UTHSCSA, San Antonio, TX Increased Serum Soluble ST2 In Asthmatic Children and Recurrent Early Wheezers Prof. Hai Lee Chung, MD, PhD and Dr. Eun Joo Lee, Catholic University of Taegu, Taegu, South Korea

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The Impact of Environmental Factors on Asthma 5201 Tuesday, March 4th, 2014, 9:45 AM - 10:45 AM 824

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High Traffic Pollution Exposure Is Significantly Associated With Poorer Asthma-Related Quality Of Life In Older Asthmatics Dr. Jennifer A. Kannan1, Dr. David I. Bernstein, MD, FAAAAI2, Ms. Cheryl Koff Bernstein, RN BSN CCRC3, Dr. Patrick Ryan, PhD1,4, Dr. Jonathan A. Bernstein, MD, FAAAAI5, Dr. Manuel S. Villareal, MD, FAAAAI1, Dr. Andrew M. Smith, MD, FAAAAI6, Dr. Peter Lenz1 and Dr. Tolly Epstein, MD, MS7, 1University of Cincinnati Medical Center, Cincinnati, OH, 2Bernstein Allergy Group, Cincinnati, OH, 3Bernstein Clinical Research Center, LLC, Cincinnati, OH, 4Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 5Division of Immunology Allergy & Rheumatology, University of Cincinnati Medical Center, Cincinnati, OH, 6 3255 Eden Ave., HPB 350, University of Cincinnati Medical Center, Cincinnati, OH, 7Allergy Partners of Central Indiana, Indianapolis, IN Effect Of Early Exposure To Traffic Related Air Pollution On The Asthma Predictive Index and Asthma At Age 7 Dr. Priyal Amin, DO, University of Cincinnati, College of Medicine, Cincinnati, OH, Afghanistan, Prof. Linda Levin, PhD, University of Cincinnati, Cincinnati, OH, Dr. Tolly Epstein, MD, MS, Allergy Partners of Central Indiana, Indianapolis, IN, Dr. Patrick Ryan, PhD, Cincinnati Children’s Hospital Medical Center,

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Cincinnati, OH and Dr. David I. Bernstein, MD, FAAAAI, Bernstein Allergy Group, Cincinnati, OH Twins’ Increased Risk Of Asthma Compared To Singletons Is Mediated By Gestational Age Vilhelmina Ullemar1, Cecilia Lundholm, MSc1 and Prof. Catarina Almqvist, MD, PhD1,2, 1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, 2Department of Women’s and Children’s Health, Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden Viral Etiology Of Early Life Wheezing Illnesses Differentially Predict Persistence Of Asthma In High-Risk Children Dr. Frederick Rubner, MD1, Dr. Daniel J. Jackson, MD2, Mr. Michael D. Evans, MS1, Dr. James E. Gern, MD, FAAAAI1 and Dr. Robert F. Lemanske Jr., MD, FAAAAI1, 1University of Wisconsin School of Medicine and Public Health, Madison, WI, 2Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI Prevalence and Severity Of Wheezing In The First Year Of Life Among Infants With Low Birth Weight Dr. Nathalia Barroso1, Dr. Leila Borges, MD1, Dr. Gustavo Wandalsen, MD2, Dr. Elaine Prestes3, Prof. Herberto J. Chong Neto, MD, PhD, FAAAAI4, Prof. Nelson A. Rosario, MD, PhD, FAAAAI5, Dr. Ana Carolina Dela Bianca6, Dr. Carolina Aranda7, Dr. Decio Medeiros6, Prof. Emanuel Sarinho, Prof. PHD8, Dr. Lillian SANCHEZ LACERDA Moraes, MD, MSc9, Dr. Javier Mallol10 and Prof. Dirceu Sole, MD, PhD7, 1UNIFESP, Brazil, 2 UNIFESP, Sao Paulo, Brazil, 3State University of Para, 4Federal University of Parana, Brazil, 5Federal University of Parana, Curitiba, Brazil, 6Federal University of Pernambuco, 7Federal University of Sao Paulo, Sao Paulo, Brazil, 8UFPE, Universidade Federal de Pernambuco, Brazil, 9Federal University of Mato Grosso, 10University of Santiago de Chile Interactive Exploration Of Microbial Exposure, Asthma and Allergy Using a Web-Based Tool Jeremy Wildfire1, Mr. Agustin Calatroni, MA MS1, Dr. Susan V. Lynch, PhD2, Dr. Homer A. Boushey Jr., MD, FAAAAI3, Dr. Kei Fujimura, PhD2, Dr. Marcus Rauch, PhD2 and Henry Lynn1, 1 Rho, Inc., Chapel Hill, NC, 2University of California San Francisco, San Francisco, CA, 3University of California, San Francisco, San Francisco, CA Is There a Link Between Uncontrolled Asthma and Sensitization To Inhalant Allergens? Dr. Majdy Qutub, MD1, Prof. Emad Abdulkader Koshak, MD1, Dr. Moufag Tayeb2 and Dr. Mohammed Alrabea1, 1King Abdul Aziz University, Jeddah, Saudi Arabia, 2King Abdul Aziz University, Rabigh, Saudi Arabia Allergy To Cockroaches: The Need For Standardization Of Extracts For Clinical Practice Prof. Emanuel Sarinho, Prof. PHD, UFPE, Universidade Federal de Pernambuco, Brazil, Dr. Filipe Wanick Sarinho, Md, IMIP, Brazil, Prof. Dirceu Sole, MD, PhD, Federal University of Sao Paulo, Sao Paulo, Brazil and Dr. Isabela Londres, UFPE Are Environmental Factors More Important Than Genetic Factors In Incident Asthma? Dr. Efren L. Rael, MD, FAAAAI, Allergy/Immunology, Penn State University College of Medicine, Hershey, PA Sensitization In Patients With Allergic Difficult-To-Control Asthma Dr. Rosana C. Agondi, MD, PhD1, Dr. Bruna Saliba2, Dr. Carla Bisaccioni, MD1, Dr. Marcelo Vivolo Aun, MD1, Prof. Jorge Kalil, MD, PhD1 and Prof. Pedro Giavina-Bianchi, MD, PhD, FAAAAI1,3, 1Clinical Immunology and Allergy Division, University of Sao Paulo, Sao Paulo, Brazil, 2Clinical Immunology and Allergy Division University of S^ao Paulo, Brazil, Brazil, 3Clinical Imunnology and Allergy Division, University of Sao Paulo, Boston, MA

TUESDAY

Abstracts AB349

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

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Sensitization To Inhalant Allergens In Elderly Patients Of An Allergy Clinic In Rio De Janeiro Dr. Jose Luiz M. Rios, MD, PhD, Dr. Luiz C G Arcanjo, Fabio C Kuschnir, Joao BM Rios and Ana CS Oliveira, Policlinica Geral do Rio de Janeiro, Brazil

J ALLERGY CLIN IMMUNOL FEBRUARY 2014

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Diagnostic Modalities of Asthma 5202 Tuesday, March 4th, 2014, 9:45 AM - 10:45 AM 835

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The Evaluation Of Airway Obstruction By Lung Sound Analysis In The Patients With Asthma Dr. Terufumi Shimoda, MD1, Dr. Yukio Nagasaka, MD2, Dr. Yasushi Obase, MD3, Dr. Michiyoshi Imaoka, MD1, Dr. Tomoaki Iwanaga, MD1 and Dr. Reiko T. Kishikawa, MD1, 1Fukuoka National Hospital, Fukuoka, Japan, 2Kyoto Respiratory Center, Otowa Hospital, Kyoto, Japan, 3Kawasaki Medical School, Kurashiki, Japan IOS Is Useful In Younger Children Who Cannot Perform Spirometry Dr. Shintaro Okazaki, MD, Hiroki Murai, MD, PhD, Hisako Hayashi, MD, Akiko Kawakita, MD, Motoko Yasutomi, MD, PhD, Mitsufumi Mayumi, MD, PhD and Yusei Ohshima, MD, PhD, University of Fukui, Fukui, Japan The Association Of Spirometry With Asthma Control and Asthma Morbidity In Inner City Schoolchildren With Asthma Dr. Watcharoot Kanchongkittiphon, MD, PhD1,2, Dr. Jonathan M. Gaffin, MD, MMSc1,3, Dr. Lianne S. Kopel, MD1,3, Dr. William J. Sheehan, MD1,3, Dr. Sachin N. Baxi, MD1,3, Dr. Perdita Permaul, MD3,4, Dr. Diane R. Gold, MD, MPH3,5 and Dr. Wanda Phipatanakul, MD, MS, FAAAAI1,3, 1Boston Children’s Hospital, Boston, MA, 2Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 3Harvard Medical School, Boston, MA, 4Division of Pediatric Allergy/Immunology, Massachusetts General Hospital, Boston, MA, 5Channing Laboratory, Brigham and Women’s Hospital, Boston, MA Impulse Oscillometry (IOS) Is Easier Than Spirometry For Older Asthmatic and Non-Asthmatic Subjects Dr. Michael C. Balduzzi, MD1, Dr. Adam Updegraff, DO1, Dr. Kerri Rawson, Ph.D, MS2, Dr. Brice Taylor, MD3, Dr. Monroe J. King, DO, FAAAAI4 and Dr. Richard F. Lockey, MD5, 1University of South Florida, Tampa, FL, 2Washington University School of Medicine of Medicine, St. Louis,, MO, 3Morsani College of Medicine, University of South FLorida, Tampa, FL, 4University of South Florida, Largo, FL, 5Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine and James A. Haley Veterans’ Affairs Hospital, Tampa, FL Clinical and Spirometric Characteristics In Young Patients With Intermittent and Mild Persistent Atopic Asthma Prof. Vera Tsybulkina1, Dr. N. Kurmaeva1, Dr. Nicolai Tsybulkin1 and Prof. Lawrence M. DuBuske, MD, FAAAAI2, 1Kazan State Medical University, Russia, 2George Washington University School of Medicine, DC Clinical Impact Of Molecular Diagnosis In Dog Allergy Prof. Joaquin Sastre, MD, PhD, FAAAAI and Ms. Silvia Uriarte, Fundacion Jimenez Dıaz, Madrid, Spain Asthma As An Unrecognized Risk Factor For Herpes Zoster In Adults: A Population-Based Case-Control Study Dr. Young J. Juhn, MD, MPH1, Dr. Hyo-Jin Kwon1, Dr. Duk Won Bang1, Dr. Eun Na Kim1, Peter Wollan2 and Mr. Brian Lahr2, 1Dept of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, 2Mayo Clinic, Rochester, MN

The Simplified Method For Eucapnic Voluntary Hyperventilation (EVH) May Be Useful To Discriminate Between Hyperventilation and Gastroesophageal Reflux Disease (GERD) Induced Bronchospasm Dr. Richard R. Rosenthal, MD1,2, Mr. Harvey Howe, BS3 and Mr. Paul Knause, BS3, 1Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, 2INOVA Fairfax Hospital, Fairfax, VA, 3Self A Young Adult With Increased Variability Of FEF25-75 Relative To FEV1 Post-Bronchial Thermoplasty Dr. Amy M. CaJacob, MD1, Dr. Mark H. Kalenian, MD, FAAAAI2, Dr. John T. Anderson, MD1, Dr. Mark Dransfield3 and Dr. Jennifer Trevor, MD1, 1University of Alabama at Birmingham, Birmingham, AL, 2Alabama Asthma and Allergy, PC, Dothan, AL, 3 University of Alabama School of Medicine, AL

Basic and Translational Immunology 5203 Tuesday, March 4th, 2014, 9:45 AM - 10:45 AM 844

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Interferon-~ a-Release Assay Prevents Unnecessary Tuberculosis Therapy In Individuals With Positive Tuberculin Skin Test Dr. Vered Schichter-konfino and Prof. Elias Toubi, Bnai-Zion Medical Center, Rappaport Faculty of Medicine, Technion, HaifaIsrael, Haifa, Israel High Dimensional Single-Cell Mass Cytometry Demonstrates Conserved Human Toll-Like-Receptor Activation Signatures Dr. Elena Hsieh, MD1, Dr. William O’Gorman, PhD2, Ms. Erica Savig2, Dr. Pier Federico Gherardini, PhD2, Prof. Mark Davis, PhD2 and Prof. Garry Nolan, PhD2, 1Allergy and Immunology, Stanford University, Stanford, CA, 2Stanford University-Microbiology & Immunology, Stanford, CA Heterogenous Nuclear Ribonucleoprotein L Regulates The Selective Expression Of Glucocorticoid Receptor Translational Isoforms In HL-60 Cells Newton Li, MD, Ingrid Bender and Nick Lu, PhD, Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL Dendrimeric Silica Particle Composites For IgE Determination In Patients Allergic To Amoxicillin Dr. Maria Isabel Monta~ nez, PhD1,2, Dr. Yolanda Vida, PhD2,3, Dr. 1 Adriana Ariza, PhD , Dr. Cristobalina Mayorga, PhD1, Dr. Maria Salas, MD, PhD4, Dr. Miguel Blanca, MD, PhD4, Dr. Ezequiel Perez-Inestrosa, PhD2,3 and Dr. Marıa Jose Torres, MD, PhD4, 1Research Laboratory for Allergic Diseases, Hospital Regional Universitario de Malaga - FIMABIS-IBIMA, Malaga, Spain, 2Andalusian Centre for Nanomedicine and Biotechnology, BIONAND, Malaga, Spain, 3Organic Chemistry, University of Malaga, Malaga, Spain, 4 Allergy Service, Carlos Haya Hospital, Malaga, Spain Murine Splenocytes From Peanut-Allergic Donors Transfer Peanut Allergy To Na€ıve, Irradiated Recipient Mice Daphne Moutsoglou, BS and Dr. Stephen C. Dreskin, MD, PhD, FAAAAI, University of Colorado Denver, Aurora, CO Alternaria-Induced Releases Of IL-1 Alpha and IL-1 Beta From Airway Epithelial Cells Through Syk and PKC Signaling Pathways Dr. Yonghan Sun, gil hospital, Incheon, South Korea and Hirohito Kita, MD, Mayo Clinic Rochester, Rochester, MN Transmaternal Bisphenol A Exposure Accelerates Diabetes Type 1 Development In NOD Mice Dr. Johanna Bodin1, Dr. Anette Kocbach Bølling1, Dr. Rune Becher1, Prof. Frieke Kuper2, Prof. Martinus Lovik1 and Dr. Unni C. Nygaard1, 1Norwegian Institute of Public Health, Oslo, Norway, 2 TNO Nutrition and Food Research, Zeist, Netherlands

Abstracts AB351

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

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Soluble Type I Interferon Receptor 2 and Soluble Type II Interferon Receptor 1 Are Independently Regulated Thomas B. Lavoie, PhD, Taher Fatakdawala, Xiao-Hong Lin, Michael Skawinski, Jonathan Ferriera and Tara Stauffer, PBL Assay Science Regulation Of Innate Immune Recognition Of Viral Infection By Epigallocatechin Gallate Dr. Christina L. Nance, PhD1,2, Melinda Mata, B.S.1, Ashley McMullen, B.S.1, Sean McMaster, B.S.1 and Dr. William T. Shearer, MD, PhD, FAAAAI1,2, 1Baylor College of Medicine, 2 Texas Children’s Hospital Prostaglandin I2 (PGI2) Inhibits IL-33-Induced Type 2 Cytokine Responses By Mouse CD4 T Cells Weisong Zhou, PhD1, Jian Zhang, MS1, Kasia Goleniewska2 and Dr. R. Stokes Peebles Jr., MD, FAAAAI1, 1Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, 2Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN Sequencing Of The ST2 Gene and The Identification Of Genetic Determinants Of Serum Total ST2 Levels: Strong Evidence For Replication Across European and African American Populations Dr. Rasika A. Mathias, ScD1, Lili Huang, MPH1, Dr. Candelaria I. Vergara, MD, PhD1, Dr. Li Gao, MD, PhD1, Nicholas M. Rafaels1, Joseph Potee1, Mrs. Monica Campbell1, Dr. Hironori Masuko, MD, PhD1, Justyna Fert-Bober2, James Snider3, Dr. Margaret Taub, PhD4, Dr. Ingo Ruczinski, PhD4, Dr. Terri H Beaty, PhD4, Dr. Jennifer E. Van Eyk, PhD2 and Dr. Kathleen C. Barnes, PhD FAAAAI1, 1Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, MD, 2Department of Medicine, Johns Hopkins University, Baltimore, MD, 3 Critical Diagnostics, San Diego, CA, 4Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD Salmonella Typhimurium Impedes Innate Immunity With a Mast Cell-Suppressing Tyrosine Phosphatase Sptp Hae Woong Choi1, Rhea Brooking, PhD1, Subham Neupane1, Chul-Jin Lee, PhD1, Dr. Edward Miao, MD, PhD2, Dr. Herman F. Staats, PhD1 and Dr. Soman N. Abraham, PhD1,3, 1Duke University Medical Center, Durham, NC, 2University of North Carolina at Chapel Hill, Chapel Hill, 3Duke-National University of Singapore, Singapore, Singapore The Role Of Semaphorin 7A In Alternatively Activation Of Macrophages Prof. Hye-Ryun Kang, MD, PhD, Dr. Hyun Seung Lee, PhD, Ms. Da Eun Park, B.A., Ms. Ji Won Lee, B.A., Prof. Woo-Jung Song, MD, Prof. Heung-Woo Park, MD, PhD, Prof. Sang Heon Cho, MD, PhD and Prof. Kyung-Up Min, MD, PhD, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea Immune Perturbation In Patients With Tgfbeta Pathway Defects Dr. Dat Q. Tran, MD1, Mrs. Ellen Regalado2 and Dr. Dianna Milewicz2, 1University of Texas Medical School at Houston, Houston, TX, 2UTHealth Chemokine Receptors On Regulatory T Cell Surface, Surrogate Markers For Intracellular Th1 and Th2 Cytokines Mr. Satoru Watanabe1,2, Dr. Yoshiyuki Yamada1 and Prof. Hirokazu Murakami2, 1Gunma Children’s Medical Center, Shibukawa, Gunma, Japan, 2Gunma University Faculty of Medicine School of Health Science, Maebashi, Gunma, Japan IL-4 Signaling Attenuates gd T Cell IL-17A Protein Expression Melissa T. Harintho, BS1, Dr. Dawn C. Newcomb Baker, PhD2, Jacqueline-Yvonne Cephus, BS2, Kasia Goleniewska3 and Dr. R. Stokes Peebles Jr., MD, FAAAAI2, 1Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, 2Division of Allergy, Pulmonary and Critical Care Medicine,

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Vanderbilt University School of Medicine, Nashville, TN, 3Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN Influence Of Dietary Fiber On Cellular Immunity In Experimental Vitamin Deficiency Dr. Roman Khanferyan, MD, PhD1, Dr. E.N. Trushina2, O.K. Mustafina3, V.M. Kodentzova2 and Prof. Lawrence M. DuBuske, MD, FAAAAI4, 1Insitute of Nutrition, Russian Academy of medical Sciences, Moscow, Russia, 2Insitute of Nutrition Russian Academy of Sciences, Russia, 3Institute of Nutrition Russian Academy of Sciences, Russia, 4George Washington University School of Medicine, DC Evaluation Of Cytokine Levels In Patients With Active Pulmonary Tuberculosis Their Household Contacts-A Follow Up Study Ms. Ramya Sivangala1, Ms. Meenakshi Ponnana1, Ms. Shruthi Thada1, Mrs. Lavanya Joshi1, Dr. Vijayalakshmi Valluri1,2 and Dr. Sumanlatha Gaddam1, 1Bhagwan mahavir medical research center, Hyderabad, India, 2LEPRA India—Blue Peter Public Health & Research Centre, Hyderabad, India Semaphorin 4C Is An Intrinsic Regulator Of Cell-Cell Interaction In Th2 Stimulated Memory-B-Cells Ms. Marianne Beland1, Dr. Marylin Desjardins, MD1,2, Ms. Di Xue3 and Dr. Bruce D. Mazer, MD, FAAAAI4,5, 1Meakins-Christie Laboratories, Montreal, QC, Canada, 2Division of Allergy and Clinical Immunology, Department of Paediatrics, McGill University Health Centre, Montreal, QC, Canada, 3Mcgill university, Montreal, QC, Canada, 4Montreal Children’s Hospital, Montreal, QC, Canada, 5Meakins-Christie Laboratories, Research Institute - McGill University Health Centre, Montreal, QC, Canada

Innate Immunity and Primary Immunodeficiencies 5204 Tuesday, March 4th, 2014, 9:45 AM - 10:45 AM 863

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A Patient With a Novel Leukocyte Adhesion Deficiency and Pyoderma Gangrenosum-Like Disease Dr. Jared I. Darveaux, MD1, Dr. Anna Huttenlocher2, Dr. Daniel Bennett3, Dr. Judith Smith3, Dr. Christine M. Seroogy, MD, FAAAAI3 and Dr. James E. Gern, MD, FAAAAI4, 1University of Wisoconsin, Madison, WI, 2University of Wisconsin, Madison, Madison, WI, 3University of Wisconsin, Madison, WI, 4University of Wisconsin School of Medicine and Public Health, Madison, WI Reduced Macrophages IL-12 Production After Stimulation By BCG/INF-Gamma Suggestive Of Impaired INF-Gamma Pathway Signalling In a Child With Disseminated Atypical Mycobacterial Infection and History Of Chemotherapy For Langerhans Cell Histiocytosis Dr. Eliska Furlong, MD, PhD, Dr. Richard K.S. Loh, MD, FAAAAI, Dr. Grace Wooi Kee Gong, MD and Dr. Andrew McLean-Tooke, MBChB, Princess Margaret Hospital for Children, Perth, Australia Sporadic Case Of Chronic Mucocutaneous Candidiasis (CMC) Due To a Gain-Of-Function Mutation In STAT1 In a 13 Year Old Female Dr. Aimee E. Baer Ellington, MD and Dr. Jennifer A. Shih, MD, Emory University, Atlanta, GA A Young Boy With a Novel, Autosomal-Dominant Signal Transducer and Activator Of Transcription 1 (STAT1) Hypermorphic Mutation Presenting With Pneumocystis Jirovecii Pneumonia (PJP), Chronic Mucocutaneous Candidiasis (CMC), and Combined Immunodeficiency Dr. Matthew C. Altman, MD1, Dr. David Hagin, MD1, Dr. David Buchbinder, MD2, Dr. Suzanne Skoda-Smith, MD3, Dr. Hans D.

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Ochs, MD1 and Dr. Troy R. Torgerson, MD, PhD1, 1University of Washington, Seattle, WA, 2Children’s of Orange County, 3Seattle Childrens Hospital, Seattle, WA 867 Infections In Mannose-Binding Lectin Deficiency Patients Dr. Mary K. Paul, MD1,2, Dr. Christopher Chang, MD, PhD, FAAAAI2, Dr. Magee DeFelice, MD3, Dr. Gang Ye, PhD4 and Dr. Sam Soundar, PhD5, 1Thomas Jefferson University Hospital, Philadelphia, PA, 2Alfred I duPont Hospital for Children, Wilmington, DE, 3Nemours/AI duPont Hospital for Children, Philadelphia, PA, 4Nemours, Orlando, FL, 5Nemours 868 LRBA Causes Immunodeficiency and Autoimmunity By Deregulating NFkB-Mediated Multiple Immune Effectors Critical For B Cell Activation Dr. Jia-Wang Wang, PhD1, Mrs. Michelle A. Reiser, MS1, Mrs. Kunyu Li, BS1, Ms. Eileen Rifkin1, Ms. Bangmei Wang1, Dr. Narasaiah Kolliputi, PhD1 and Dr. Richard F. Lockey, MD1,2, 1Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida, Morsani College of Medicine, Tampa, FL, 2 James A. Haley Veterans’ Affairs Hospital, Tampa, FL 869 Giscelli Syndrome: A Case Treated With a Hematopoietic Stems Cells From a Cord Blood Dr. Marisol Rico-Arroyo, Instituto Mexicano del Seguro Social 870 Fungal Granuloma and Chronic Mucocutaneous Candidiasis Due To Autosomal Dominant Gain Of Function STAT1 Mutation Dr. Nauman Salim, MBBS , MD, University of South Florida, Tampa, FL and Dr. Jennifer Leiding, MD, University of South Florida, St. Petersburg, FL 871 Impaired T-Independent IgM Responses Due To Irak-4-, MyD88 Deficiency Or Splenectomy Dr. Paul J. Maglione, MD, PhD1, Lin Radigan1, Sam Black1, Jessica Overbey1, Dr. Emelia Bagiella1, Dr. Isabelle Meyts2, Prof. Jean-Laurent Casanova, MD, PhD3,4, Dr. Capucine Picard, MD, PhD3 and Dr. Charlotte Cunningham-Rundles, MD, PhD, FAAAAI1, 1Mount Sinai Medical Center, New York, NY, 2University Hospitals Leuven, Belgium, 3Hopital Necker-Enfants Malades, Paris, France, 4Rockefeller University, New York, NY 872 Intestinal Perforation and Non-Tuberculous Mycobacterial Peritonitis In a Patient With Interleukin-1 Receptor Associated Kinase 4 Deficiency Dr. Hana B. Niebur, MD, Dr. Nathan Tang, MD, FAAAAI and Dr. Jennifer Leiding, MD, University of South Florida, St. Petersburg, FL 873 Suspected Non-Infectious Prosthetic Valve Inflammatory Dehiscence In X-Linked Chronic Granulomatous Disease Dr. Monica Bhagat, MD1, Dr. Joshua A. Steinberg, MD2, Dr. Frank Silvestry, MD3, Dr. Lea Surrey, MD3, Dr. Andrea J. Apter, MD MA MSc FAAAAI1, Dr. Patricia A. Takach, MD, FAAAAI1 and Dr. Benjamin P. Soule, MD1, 1University of Pennsylvania, Philadelphia, PA, 2Medical College of Wisconsin, Milwaukee, WI, 3 UPENN, Philadelphia, PA 873A The Effects Of Anti-Seizure Medications On Patients With Antibody Deficiency Syndrome Dr. Tatyana Gavrilova, MD and Dr. Harumi Jyonouchi, MD, Rutgers University of Medicine and Dentistry, Newark, NJ

J ALLERGY CLIN IMMUNOL FEBRUARY 2014

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Epidemiology and Risk Factors of Asthma 5205 Tuesday, March 4th, 2014, 9:45 AM - 10:45 AM 874

Risk Factors Associated With The Development Of Asthma and Allergic Rhinitis Among Adolescents Living In S~ ao Paulo – Brazil Dr. Fernanda Patini Furlan1, Dr. Djanira Andrade2, Danielli Christinni Bichuete-Silva, MD3, Dr. Tessa Rachel Tranquilini

Gonc¸alves, MD3, Dr. In^es Camelo Nunes2 and Prof. Dirceu Sole, MD, PhD3, 1Division of Allergy and Clinical Immunology, Dept of Pediatrics, Escola Paulista de Medicina, Federal University of S~ao Paulo, S~ao Paulo, Brazil, S~ao Paulo, Brazil, 2Universidade Federal de S~ao Paulo, S~ao Paulo, Brazil, 3Federal University of Sao Paulo, Sao Paulo, Brazil Atopic Associations In Asthmatic Patients Readmitted Within 30 Days To The Hospital Dr. Larisa Buyantseva, MD, MS, Dr. Melissa Rossi, Prof. Jason Liao, PhD and Dr. Timothy Craig, D.O., Penn State University, Hershey, PA Pediatric Asthma Associated With Fungal Exposure Dr. Cecilia Nguyen, MD1, Dr. Christina E. Ciaccio, MD, FAAAAI2 and Dr. Charles Barnes, PhD2, 1Children’s Mercy Hospitals and Clinics, 2Children’s Mercy Hospital, Kansas City, MO Assessment Of Factors Associated With PPV23 Vaccine Uptake Among Young Adults With Asthma In Olmsted County, MN Maria J. Bachman, Medical Student1, Joshua Gauger, Medical Student2, Dr. Chriss Derauf, MD3, Dr. Slavica Katusic, MD3, Jen Rand-Weaver3, YuBin Choi3, Elizabeth Krusemark3 and Dr. Young J. Juhn, MD, MPH3, 1Mayo Medical School, Rochester, MN, 2 Mayo Medical School, 3Dept of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN Clinical Effectiveness In Allergic Airway Disease Of Oriton IgE Chemiphar TM: A Rapid Determination System Of AllergenSpecific IgE Dr. Tomoyuki Soma, MD1,2, Dr. Ai Masumoto2, Dr. Takehito Kobayashi, MD2, Dr. Atsushi Kamijyo, MD2, Dr. Yoshitaka Uchida1,2, Prof. Kouichi Hagiwara, MD1, Prof. Minoru Kanazawa, MD1 and Prof. Makoto Nagata, MD1,2, 1Department of Respiratory Disease, Saitama Medical University, Japan, 2Allergy Center, Saitama Medical University, Japan Gender Differentially Contributes To Airway Hyperresponsiveness In Adult Asthmatics Dr. Jeong-Hee Choi, MD1, Dr. Cheol-Hong Kim, MD2, Prof. In-Gyu Hyun, MD3, Dr. Joo-Hee Kim, MD4, Dr. Tae-Rim Shin, MD5 and Dr. Sang-Myeon Park, MD5, 1Dept. of Pulmonology and Allergy, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, South Korea, 2Dept. of pulmonology and Allergy, Hallym University Dongtan Sacred Heart Hospital, 3Hallym University Dongtan Sacred Heart Hospital, 4Hallym University School of Medicine, Anyang, 5Hallym University Kangnam Sacred Heart Hospital Prevalence Of Sleep Disorders In Children With Asthma and Its Association With The Level Of Control Of The Disease, Smoking and Obesity Dr. Lorena Rangel-Garza, MD1, Prof. Sandra N. Gonzalez-Diaz, MD, PhD, FAAAAI1, Dr. Alejandra Macias-Weinmann, MD2, Prof. Alfredo Arias-Cruz, MD, FAAAAI1, Dr. Maria Del Carmen ZarateHernandez, MD3, Dr. Idalia V. Yanez-Perez, MD4 and Dr. Hilda Hernandez-Sanchez, MD4, 1University Hospital Dr. Jose Eleuterio Gonzalez, UANL, Monterrey, Mexico, 2Hospital Universitario UANL, Monterrey, N.L., Mexico, 3University Hospital, Monterrey, Mexico, 4Regional Center of Allergy and Clinical Immunology. University Hospital ‘‘Dr. Jose Eleuterio Gonzalez’’., Monterrey, Mexico Asthma and Allergic Diseases Of Preschool Children In Korea: Findings From The Pilot Study For The Korean Surveillance Survey For Childhood Asthma Prof. Ji Tae Choung, MD, Korea Univ. Medical Center, Seoul, Prof. Sungchul Seo, The Enviornmental Health Center for Asthma, Korea University, Seoul, Dr. YongMin Cho, The environmental health center for asthma, Dr. Young Yoo, MD, PhD, Department of Pediatrics, College of Medicine, Korea University, Seoul, South Korea; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY and Dr. Wonsuck Yoon, Department of Life Science and Biotechnology, Seoul, South Korea

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Atopic Characteristics Of Patients With Paroxysmal Vocal Cord Dysfunction Casey Curtis, MD1,2, Meagan W. Shepherd, MD1,2, Gary Phillips, M.A.S.3 and Princess U. Ogbogu, MD, FAAAAI1,2, 1Wexner Medical Center at the Ohio State University, Columbus, OH, 2Nationwide Children’s Hospital, Columbus, OH, 3Wexner Medical Center at The Ohio State University, Columbus, OH Relationship Of Allergen Sensitization and LUNG Function In Adults Patients With Asthma In Allergy Clinic In Monterrey, Mexico Dr. Hilda Hernandez Sanchez, MD, Prof. Sandra N. GonzalezDiaz, MD, PhD, FAAAAI, Prof. Alejandra Macias-Weinmann, MD, Prof. Alfredo Arias-Cruz, MD, FAAAAI, Dr. Idalia Vanessa Yanez-Perez, MD and Dr. Lorena Rangel-Garza, MD, University Hospital Dr. Jose Eleuterio Gonzalez, UANL, Monterrey, Mexico Targeting Patient Eduation: Correlating Fluctuating Pollen Counts With Patient Online Inquiries Into Asthma and Allergic Rhinitis Dr. John M. Kern, D.O.1, Dr. Leonard Bielory, MD, FAAAAI2,3 and Mr. Spencer H. Luster3,4, 1Rutgers University - NJMS, oceanport, NJ, 2Robert Wood Johnson University Hospital, New Brunswick, NJ, 3STARx Allergy and Asthma Center, Springfield, NJ, 4 University of Pennsylvania, Philadelphia, PA

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Eosinophilic Gastrointestinal Diseases 5206 Tuesday, March 4th, 2014, 9:45 AM - 10:45 AM 886

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Elevated Exhaled Nitric Oxide Levels In Eosinophilic Esophagitis Patients With and Without Atopy Michael Kagen, M.D.1, Zainab Kagen, MD2, Prof. Steve L. Kagen, MD, FAAAAI3 and Joe Zondlo, M.D.3, 1University of Tennessee College of Medicine-Chattanooga, Chattanooga, TN, 2University of Tennesee College of Medicine-Chattanooga, TN, 3Kagen Allergy Clinic, Appleton, WI Older Mice Intranasally Sensitized with Aspergillus Fumigatus Develop Stronger Eosinophilic Esophageal Inflammation Compared to Their Younger Counterparts Dr. Antonella Cianferoni, MD, PhD1, Simona Barni, MD2, Cara Smith, BS3, Valsamma Abraham, PhD4, Peng Guan, BS3, Dr. Francesca Saretta, MD5, Katie Ruyman, BS3, Hamid Bassiri, MD, PhD3, Dr. Kim E. Nichols, MD6 and Dr. Jonathan M. Spergel, MD, PhD, FAAAAI3,7, 1The Children’s Hospital of Philadelphia, 2University of Florence Italy, Italy, 3Children’s Hospital of Philadelphia, 4University of Pennsylvania, 5Ospedale Di Palmanova, ASS 5 Bassa Friulana, Pagnacco, Italy, 6CChildren’s Hospital of Philadelphia, Philadelphia, PA, 7 The Children’s Hospital of Philadelphia, Philadelphia, PA Cripto-1 Is Elevated In Pediatric Subjects With Eosinophilic Esophagitis Lisa Beppu, BS1, Arjun Andrew Anilkumar, BS2, Richard Kurten, PhD3, Ranjan Dohil, MD4, David Broide, MB ChB2 and Seema Sharma Aceves, MD, PhD, FAAAAI5, 1University of California San Diego, Department of Pediatrics, Division of Allergy and Immunology, 2University of California San Diego, Department of Medicine, Division of Allergy and Immunology, 3University of Arkansas for Medical Sciences, Little Rock, AR, 4University of California San Diego, Rady Children’s Hospital, Department of Pediatrics, Division of Gastroenterology, 5Pediatrics, University of California San Diego, La Jolla, CA Interleukin-33 and Thymic Stromal Lymphopoietin Are Preferentially Elevated In The Sera Of Infants With Eosinophilic Gastroenteritis Dr. Ichiro Nomura, MD, PhD1,2, Dr. Akio Matsuda, PhD2, Dr. Tetsuo Shoda, MD2, Dr. Hideaki Morita, MD., PhD.2, Dr. Katsuhiro

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Arai, MD3, Dr. Hirotaka Shimizu, MD3, Dr. Yoshiyuki Yamada, MD, PhD4, Dr. Yukihiro Ohya, MD, PhD1, Dr. Hirohisa Saito, MD., PhD.2 and Dr. Kenji Matsumoto, MD, PhD2, 1Division of Allergy, National Center for Child Health and Development, Tokyo, Japan, 2Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan, 3Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan, 4Gunma Children’s Medical Center, Shibukawa, Japan Comprehensive Analysis Of Offending Milk Protein Components In Non-IgE-Mediated Gastrointestinal Food Allergies By Antigen-Specific Lymphocyte Proliferation Test Dr. Tetsuo Shoda, M.D., Dr. Ichiro Nomura, MD, PhD, Dr. Hideaki Morita, MD., PhD., Dr. Akio Matsuda, PhD, Dr. Hirohisa Saito, MD., PhD. and Dr. Kenji Matsumoto, MD, PhD, Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan Milk Elimination Diet For Treatment Of Eosinophilic Esophagitis Elizabeth Erwin, MD1, Patrice Kruszewski2, Dr. John Russo, M.D.1 and Thomas A.E. Platts-Mills, MD, PhD, FAAAAI3, 1Nationwide Children’s Hospital, Columbus, OH, 2Nationwide Children’s Hospital, 3Division of Asthma, Allergy & Immunology, University of Virginia Health System, Charlottesville, VA Pediatric Eosinophilic Esophagitis: A 10-Year Experience At a Canadian Tertiary Care Centre Dr. Jason A. Ohayon, MD1, Perri R. Tutelman2, Dr. Jefferson Terry, MD, PhD3 and Dr. Mary E. Sherlock, MB BCh, BAO, PhD2, 1Department of Pediatrics, McMaster Children’s Hospital, McMaster University, Hamilton, ON, Canada, 2Department of Pediatric Gastroenterology and Nutrition, McMaster Children’s Hospital, McMaster University, Hamilton, ON, Canada, 3Department of Pathology and Molecular Medicine, McMaster Children’s Hospital, McMaster University, Hamilton, ON, Canada Clinical Characteristics Of Eosinophilic Esophagitis - a Case Series Of 30 Patients oes1,3, Dr. Susana D. Piedade1, Dr. Diana Silva1,2, Dr. Bruno Sim~ 1 4 ^ Dr. Angela Gaspar , Dr. Sandra Morgado , Dr. Filipa Santos5 and Dr. M"ario Morais-Almeida1, 1Immunoallergy Department, Hospital CUF Descobertas, Lisbon, Portugal, 2Immunoallergy Department, Hospital S~ao Jo~ao, Oporto, Portugal, 3Pediatrics Department, Hospital Faro, Faro, Portugal, 4Gastroenterology Unit, Hospital CUF Descobertas, Lisbon, Portugal, 5Pediatrics Department, Hospital CUF Descobertas, Lisbon, Portugal Characteristics Of Eosinophilic Esophagitis Among Children Living In Rural, Southern United States Ms. Erin O’Brien1,2, Dr. Troy Gibbons, MD1,2, Dr. Amy M. Scurlock, MD3, Dr. Jennifer Olivier, MD1,2, Mallikarjuna Rettiganti, PhD1,2, Maria Melguizo Castro1,2, Ms. Peggy L. Chandler, APN1,2, Audrey Fendley, RD2, Dr. Helen Casteel, MD1,2, Dr. Maryelle VonLanthen, MD1,2, Dr. Stephen Fiedorek, MD1,2, Dr. Tamara T. Perry, MD1,2, Stacie M. Jones, MD3,4 and Dr. Robbie D. Pesek1,2, 1 University of Arkansas for Medical Sciences, Little Rock, AR, 2 Arkansas Children’s Hospital, Little Rock, AR, 3University of Arkansas for Medical Sciences and Arkansas Children’s Hospital, Little Rock, AR, 4Arkansas Children’s Hospital Research Institute, Little Rock, AR Failure To Thrive In a Pediatric Cohort With Eosinophilic Esophagitis Dr. Brenda Paquet, MD, FRCPC1, Dr. Philippe B"egin, MD, MSc FRCPC1, Louis P. Paradis, MD FRCPC FAAAAI2, Dr. Eric Drouin, MD FRCPC1 and Anne M. Des Roches, MD FRCPC FAAAAI2, 1 Centre Hospitalier Universitaire Ste-Justine, Montreal, QC, Canada, 2Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada

TUESDAY

Abstracts AB353

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

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J ALLERGY CLIN IMMUNOL FEBRUARY 2014

Eosinophilic Esophagitis In The Puerto Rican Pediatric Population Dr. Carmen M. Pimentel, MD, Dr. Angel M. Rivera, MD, Dr. Iona K. Malinow, MD, Dr. Cristina J. Ramos, MD, Dr. Anardi AgostoMujica, MD, Dr. Rita Diaz, MD and Dr. Sylvette Nazario, MD, University of Puerto Rico School of Medicine, San Juan, PR Challenges With Measurement Of IgE Antibodies To Minor Components In Food Allergy: Eosinophilic Esophagitis, Peanut Allergy, and Delayed Anaphylaxis To Mammalian Meat Anubha Tripathi, MD1, Lisa J. Workman, BA1, Scott Commins, MD, PhD1, Barrett Barnes, MD2, Prof. Robert G. Hamilton, PhD D.ABMLI FAAAAI3, Thomas A.E. Platts-Mills, MD, PhD, FAAAAI1 and Elizabeth Erwin, MD4, 1Division of Asthma, Allergy & Immunology, University of Virginia Health System, Charlottesville, VA, 2Division of Pediatric Gastroenterology, University of Virginia Health System, Charlottesville, VA, 3Johns Hopkins University School of Medicine, Baltimore, MD, 4Nationwide Children’s Hospital, Columbus, OH Serum IgE To Allergen Components In Patients With Eosinophilic Esophagitis Maria Slack, MD1, Princess U. Ogbogu, MD, FAAAAI2, Anubha Tripathi, MD3, Lisa J. Workman, BA3, Thomas A.E. Platts-Mills, MD, PhD, FAAAAI3 and Elizabeth Erwin, MD4, 1Nationwide Children’s Hospital, Columbus, OH, 2Wexner Medical Center at the Ohio State University, Columbus, OH, 3Division of Asthma, Allergy & Immunology, University of Virginia Health System, Charlottesville, VA, 4Nationwide Children’s Hospital Eosinophilic Gastroenteritis Due To Egg Allergy Presenting As Acute Pancreatitis Dr. Kevin Tse, MD, UCSD and Dr. Sandra C. Christiansen, MD, FAAAAI, Southern CA Permanente Med Grp, San Diego, CA Patient Ratings Of Various Eosinophilic Esophagitis Treatment Options Dr. Samantha K. Lin, MD, Dr. Neelu Kalra, MD and Dr. Gisoo Ghaffari, MD, FAAAAI, Penn State Hershey Medical Center, Hershey, PA Eosinophilic Esophagitis and Serum Eotaxin-3 Levels: A NonInvasive Method To Monitor Disease Activity Dr. Cristina Jimenez-Aponte1, Dr. Jose Torres-Silva1, Dr. Eric Gonzalez-Hernandez1, Dr. Liza Gonzalez-Benitez1, Dr. Mairim Wiscovich-Torres1, Dr. Carlos Camacho1 and Dr. Vylma Velazquez, MD2, 1Hospital Episcopal San Lucas-Ponce, 2Hospital Episcopal San Lucas, Ponce, PR Evaluation Of Antigenic Triggers and Etiologies In Eosinophilic Esophagitis: A Single Center Experience Dr. Tanvi Patel, University of Florida, Gainesville, FL and Dr. Sarah Glover, University of Florida at Gainesville, Gainesville, FL Eosinophilic Esophagitis and Selective IgA Deficiency. A New Combined Disorder Dr. Eric Gonzalez Hernandez1, Dr. Vylma Velazquez, MD2, Dr. Carlos Camacho3 and Dr. Sheila Capre1, 1Hospital Episcopal San Lucas, 2Hospital Episcopal San Lucas, Ponce, PR, 3Hospital Episcopal San Lucas-Ponce

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Drug Allergy 5207 Tuesday, March 4th, 2014, 9:45 AM - 10:45 AM 904

Cephalosporin Cross-Reactivity In Skin Test Dr. Jong-Myung Lee, MD1,2 and Dr. Min-Hye Kim1,3, 1Regional Pharmacovigilance Center, Kyungpook National University Hospital, Daegu, South Korea, 2Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea, 3 Department of Internal Medicine,Kyungpook National University School of Medicine, Daegu, South Korea

Rituxan Hypersensitivity and Management Dr. Johnson T. Wong, MD, FAAAAI1, Dr. Aleena Banerji, MD1, Dr. Timothy P. Lax, MD2, Dr. Aidan Long, MD, FAAAAI1, Dr. Michael T. Wilson, MD, PhD1 and Dr. Caroline Sokol, MD, PhD3, 1 Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, Boston, MA, 3 Massachusetts General Hospital Diagnostic Evaluation Of Hypersensitivity Reactions To Betalactam Antibiotics In A Large Population Of Children Dr. Maria J Torres, MD, PhD1, Dr. Maria Angeles Zambonino2, noz3, Dr. Gloria ReDr. Jose Luis Corzo, MD3, Dr. Candelaria Mu~ 3 4 quena , Dr. Adriana Ariza, PhD , Dr. Cristobalina Mayorga, PhD5, Dr. Antonio Urda3 and Dr. Miguel Blanca, MD, PhD1, 1Allergy Service, Carlos Haya Hospital, M!alaga, Spain, 2Allergy Service, Carlos Haya Hospital, M!alaga, Spain, M!alaga, Spain, 3Pediatric Service, Carlos Haya Hospital, M!alaga, Spain, 4Research Laboratory for Allergic Diseases, Hospital Regional Universitario de Malaga - FIMABIS-IBIMA, Malaga, Spain, 5Research Laboratory for Allergic Diseases, Hospital Regional Universitario de Malaga IBIMA, M!alaga, Spain Clinical Presentation and Outcomes Of Children Undergoing Evaluation For Drug Allergy Dara Mairiang, MD, Dr. Wiparat Manuyakorn, MD, Wasu Kamchaisatian, MD, Soamarat Vilaiyuk, MD and Suwat Benjaponpitak, MD, Division of Pediatric Allergy/Immunology/Rheumatology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Analysis Of Drug Hypersensitivity Reactions In A Large Serie Of Children noz2, Dr. Jose Dr. Maria Angeles Zambonino1, Dr. Candelaria Mu~ Luis Corzo, MD2, Dr. Gloria Requena2, Dr. Adriana Ariza, PhD3, Dr. Cristobalina Mayorga, PhD3, Dr. Antonio Urda2, Dr. Miguel Blanca, MD, PhD1 and Dr. Maria J Torres, MD, PhD1, 1Allergy Service, Carlos Haya Hospital, M!alaga, Spain, 2Pediatric Service, Carlos Haya Hospital, M!alaga, Spain, 3Research Laboratory for Allergic Diseases, Hospital Regional Universitario de Malaga - FIMABIS-IBIMA, Malaga, Spain Assessing IgE-Mediated Reactions In Children Presenting To An Allergy Clinic With a Suspected Antibiotic Allergy Mr. Christopher Mill, BSc1, Dr. Marie-Noel Primeau, MD2, Dr. Christine Lejtenyi, MD3, Dr. Elaine J. Medoff3, Ms. Nofar Kimchi4 and Dr. Moshe Ben-Shoshan, MD, MSc5,6, 1Division of Clinical Epidemiology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada, 2McGill University Health Center, Montreal, QC, Canada, 3Montreal Children’s Hospital, Montreal, QC, Canada, 4Technion American Medical Students Program, Israel, 5Division of Paediatric Allergy and Clinical Immunology, Department of Paediatrics, McGill University Health Center, Montreal, QC, Canada, 6Montreal Children’s Hospital, Montreal, Canada Hypersensitivity Drug Reactions (HDR) In Latin America. Similarities and Differences Between Children and Adults Dr. Ricardo Cardona-Villa, MD1, Dr. Edgardo J. Jares, MD2, Dr. Maximiliano G! omez3, Dr. Luis Felipe C. Ensina, MD4, Dr. Mario S!anchez-Borges, MD, FAAAAI5, Dr. Alfredo Arias Cruz6, Dr. Carlos Serrano7, Dr. Mabel Noemi Cuello, MD8, Ivan Cherrez9, Dr. Andrea Zanacchi10, Prof. Alicia De Falco11, Dr. Silvana Monsell2, Dr. Adolfo Salvatierra12, Dr. Susana Barayazarra10, Dr. Susana Diez-Zuloaga1, Dr. Blanca Maria Morfin-Maciel, MD13, Dr. Paola Toche Pinaud14, Dr. Sandra Gonz!alez D!ıaz6 and Dr. Juan F. Schuhl, MD, FAAAAI15, 1Universidad de Antioquia, Medellin, Colombia, 2 C.M.P. SA, Buenos Aires, Argentina, 3Hospital San Bernardo, Salta, Argentina, 4Universidade Federal de S~ao Paulo, S~ao Paulo, Brazil, 5Clinica El Avila, 6a transversal Altamira, piso 8,

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consultorio 803, Caracas., Caracas, Venezuela, 6Hospital Universitario, Monterrey, Mexico, 7Fundacion Valle del Lili, Cali, Colombia, 8Consultorios San Juan, San Juan, Argentina, 9Respiralab Hospital Kennedy, Guayaquil, Ecuador, 10Nuevo Hospital San Roque, Cordoba, Argentina, 11Universidad Nacional de La Plata, La Plata, Argentina, 12Fundair, San Luis, Argentina, 13Hospital Mocel, Mexico City, Mexico, 14Clınica Las Condes, Santiago, Chile, 15 British Hospital, Montevideo, Uruguay Copy Number Variations In ALOX5 and PTGER1 Genes Are Associated With Susceptibility To AERD and Mnsaid-UA Mrs. Maria Del Carmen Plaza Seron, Bsc.1, Dr. Pedro Ayuso Parejo, PhD1, Dr. Natalia Blanca-Lopez, MD, PhD1, Dr. Inmaculada Do~ na, MD, PhD2, Dr. Jose A Cornejo-Garcia, PhD3, Dr. Marıa Jose Torres, MD, PhD2, Dr. Javier Fernandez4, Dr. Jose Julio Laguna, MD, PhD5, Veronique Godineau3, Ms. Miriam Osorio6, Mrs. Luisa Galindo, RN2, Dr. Gabriela Canto, MD, PhD1 and Dr. Miguel Blanca, MD, PhD2, 1Allergy Service, Infanta Leonor Hospital, Madrid, Spain, 2Allergy Service, Carlos Haya Hospital, Malaga, Spain, 3Research Laboratory, Carlos Haya Hospital, Malaga, Spain, 4UMH Alicante G.University Hospital - Allergy Sect., Alicante, Spain, 5De La Cruz Roja Hospital, Madrid, Spain, 6 Research Laboratory, Carlos Haya Hospital-FIMABIS, Malaga, Spain Association Study Of Genes Involved In Mast Cell Activation and Mnsaid-UA Dr. Pedro Ayuso Parejo, PhD1, Mrs. Maria del Carmen Plazana, MD, PhD2, Dr. Natalia Seron, Bsc1, Dr. Inmaculada Do~ Blanca-Lopez, MD, PhD1, Dr. Jose A Cornejo-Garcia, PhD3, Dr. Maria J Torres, MD, PhD2, Dr. Javier Fernandez4, Dr. Jose Julio Laguna, MD, PhD5, Ms. Miriam Osorio6, Veronique Godineau3, Mrs. Luisa Galindo, RN2, Dr. Cristobalina Mayorga, PhD3, Dr. Gabriela Canto, MD, PhD1 and Dr. Miguel Blanca, MD, PhD2, 1Allergy Service, Infanta Leonor Hospital, Madrid, Spain, 2Allergy Service, Carlos Haya Hospital, Malaga, Spain, 3Research Laboratory, Carlos Haya Hospital, Malaga, Spain, 4UMH Alicante G.University Hospital - Allergy Sect., Alicante, Spain, 5De La Cruz Roja Hospital, Madrid, Spain, 6Research Laboratory, Carlos Haya HospitalFIMABIS, Malaga, Spain Non-Steroidal Antiinflammatory Drugs (NSAIDs)-Induced Acute Urticaria: A Genome-Wide Association Study In The Spanish Population Dr. Jose A Cornejo-Garcia, PhD1, Dr. Mike Lee2, Dr. Natalia Blanca-Lopez, MD, PhD3, Dr. Lieh-Bang Liou4, Dr. Chien-Hsiun na, MD, PhD6, Veronique Godineau1, Chen5, Dr. Inmaculada Do~ 7 Dr. Jose Julio Laguna , Dr. F. Javier Fernandez, MD, PhD8, Dr. Pedro Ayuso Parejo, PhD3, Mrs. Maria del Carmen PlazaSeron, Bsc3, Dr. Gabriela Canto, MD, PhD3 and Dr. Miguel Blanca, MD, PhD6, 1Research Laboratory, Carlos Haya Hospital, Malaga, Spain, 2Laboratory for International Alliance on Genomic Research, RIKEN Center for Integrative Medical Sciences, Yokohama Kanagawa, Japan, 3Allergy Service, Infanta Leonor Hospital, Madrid, Spain, 4Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital at Lin-kou, Kwei-san, Tao-yuan, Taiwan, 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, 6Allergy Service, Carlos Haya Hospital, Malaga, Spain, 7Hospital De La Cruz Roja,, Madrid, Spain, 8UMH Alicante G.University Hospital - Allergy Sect., Alicante, Spain Tolerance To COX-2 Inhibitors In Children With Multiple Hypersensitivity To Non- Steroidal Anti-Inflammatory Drugs Dr. Jose Luis Corzo Higueras, MD1, Dr. Maria Angeles Zambonoz1, Dr. Cristobalina Mayorga, PhD3, nino2, Dr. Candelaria Mu~ Dr. Gloria Requena1, Dr. Antonio Urda1, Dr. Miguel Blanca, MD, PhD4 and Dr. Maria J Torres, MD, PhD4, 1Pediatric Service, Carlos Haya Hospital, Malaga, Spain, 2Allergy Service, Carlos Haya Hospital, Malaga, Spain, Malaga, Spain, 3Research Laboratory for Allergic Diseases, Hospital Regional Universitario de Malaga -

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FIMABIS-IBIMA, Malaga, Spain, 4Allergy Service, Carlos Haya Hospital, Malaga, Spain Aspirin Allergy In a High Risk VA Population and Potential Benefit From Aspirin Desensitization Bhavisha Patel, MD1,2, Joseph Karls2, Sandra Tompkins2, Dawn Nyland2, Jo Ann Clough2, Jane Ludwig2 and Sameer K. Mathur, MD, PhD, FAAAAI1,2, 1University of Wisconsin School of Medicine and Public Health, Madison, WI, 2William S. Middleton Veterans Hospital, Madison, WI Novel Protocol For Successful Aspirin Desensitization In a Patient With Laryngeal Angioedema To Aspirin Dr. Nikki Garg, MD, Dr. Pratik Patel, MD and Dr. Sindhura Bandi, MD, Rush University Medical Center, Chicago, IL Allergy To Beta-Lactams In Patients Consulting Allergology Center Of The Antioquia University, Colombia Dr. Elizabeth Lopez1, Dr. Kaddy Juliana Beltran1, Dr. Jorge Sanchez1 and Dr. Ricardo Cardona-Villa, MD2, 1Universidad de Antioquia, Colombia, 2Universidad de Antioquia, Medellin, Colombia Effect Of Penicillin Allergy On Outpatient Antibiotic Prescriptions At VA Hospital Mark Biagtan, MD1,2, Bryan Babler, BS Pharm RPh2, Sujani Kakumanu, MD1,2 and Sameer K. Mathur, MD, PhD, FAAAAI1,2, 1 University of Wisconsin School of Medicine and Public Health, Madison, WI, 2William S. Middleton Veterans Hospital, Madison, WI Value Of Clavulanic Acid In Basophil Activation Test For Evaluating Immediate Reactions To The Combination AmoxicillinClavulanic Acid Dr. Cristobalina Mayorga, PhD1, Dr. Adriana Ariza, PhD2, Dr. Inmaculada Do~ na, MD, PhD3, Dr. Maria Angeles Zambonino3, Dr. Maria Isabel Monta~ nez, PhD1, Dr. Maria Salas, MD, PhD3, Ms. Maria Dolores Ruiz3, Ms. Lidia Melendez, Lab. Tech.1, Mrs. Maria D Ca~ namero3, Dr. Miguel Blanca, MD, PhD3 and Dr. Maria J Torres, MD, PhD3, 1Research Laboratory for Allergic Diseases, Hospital Regional Universitario de Malaga - IBIMA, Malaga, Spain, 2Research Laboratory for Allergic Diseases, Hospital Regional Universitario de Malaga - FIMABIS-IBIMA, Malaga, Spain, 3 Allergy Service, Carlos Haya Hospital, Malaga, Spain Persistence Of Penicillin Allergy Label Despite Documented Tolerance Matthew Feldman, MD and Dr. David A. Khan, MD, FAAAAI, University Texas SW Medical Center, Dallas, TX Allergy To Betalactams In Brazil: Placebo Effect Or Misdiagnosis? Dr. Manoela Crespo-Magalh~ aes1, Dr. Marcelo Vivolo Aun, MD1, Dr. Roberta Almeida-Castro2, Dr. Marisa Rosimeire Ribeiro, MD3, Dr. Laila Sabino Sabino Garro, MD, PhD3, Prof. Jorge Kalil, MD, PhD1, Prof. Antonio Abılio Motta, MD, PhD3 and Prof. Pedro Giavina-Bianchi, MD, PhD, FAAAAI1, 1Clinical Immunology and Allergy Division, University of Sao Paulo, Sao Paulo, Brazil, 2Clinical Imunnology and Allergy Division, University of Sao Paulo, Sao paulo, Brazil, 3Clinical Imunnology and Allergy Division, University of Sao Paulo, Sao Paulo, Brazil Prevalence Of Reported Penicillin Allergy In a Tertiary Allergy Immunology Clinic In The United States Dr. Sara M. May, MD, Andrew Nickels, MD and Dr. Michael Park, MD, FAAAAI, Mayo Clinic, Rochester, MN Successful Oxacillin Desensitization With Interrupted Dosing Versus Continuous Infusion Dr. Melinda Braskett, MD, UCLA Med Center - Mattel Children’s Hospital, Los Angeles, CA and Dr. Monika Saeedian, MD, University of California, Los Angeles IgE To Penicillins With Different Specificities Can Be Identified By a Multiepitope Macromolecule. Bihaptenic Penicillin Structures and IgE Specificities Dr. Adriana Ariza, PhD1, Dr. Cristobalina Mayorga, PhD2, Dr. nez, Maria Jose Jose Torres, MD, PhD3, Dr. Maria Isabel Monta~

TUESDAY

Abstracts AB355

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

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PhD2, Dr. Ezequiel Perez-Inestrosa, PhD4, Dr. Antonio Jesus RuizSanchez, PhD5, Dr. Rosa Marıa Rodrıguez-Gueant, MD, PhD6, Dr. Tahıa Fernandez, PhD7, Dr. Jean Louis Gueant6 and Dr. Miguel Blanca, MD, PhD3, 1Research Laboratory for Allergic Diseases, Hospital Regional Universitario de Malaga - FIMABIS-IBIMA, Malaga, Spain, 2Research Laboratory for Allergic Diseases, Hospital Regional Universitario de Malaga - IBIMA, Malaga, Spain, 3Allergy Service, Carlos Haya Hospital, Malaga, Spain, 4Andalusian Centre for Nanomedicine and Biotechnology, BIONAND, Malaga, Spain, 5Andalusian Centre for Nanomedicine and BiotechnologyBIONAND, and Department of Organic Chemistry, Faculty of Sciences, University of Malaga, Malaga, Spain, 6Laboratory of Cellular and Molecular Pathology in Nutrition, Faculty of Medicine, University of Nancy, Nancy, France, 7Research Laboratory - FIMABIS Foundation, Malaga, Spain Cephalosporin Prescribing Habits In Penicillin Allergic Patients Dr. Shannon D. Tiedeken, MD, Nemours, A.I. duPont Hospital for Children, Conshohocken, PA, Dr. Christopher Chang, MD, PhD, FAAAAI, Alfred I duPont Hospital for Children, Wilmington, DE and Dr. Gang Ye, PhD, Nemours, Orlando, FL Radiocontrast Media Reactions: Rectifying Misconceptions About Shellfish Allergy and Iodine ‘‘Allergy’’ In An Academic Institution Dr. Amber N. Pepper, MD1, Dr. Emma Westermann-Clark, MD, MA1, Dr. Neetu Talreja, MD2 and Dr. Richard F. Lockey, MD2, 1 Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, FL, 2Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine and James A. Haley Veterans’ Affairs Hospital, Tampa, FL Clinical Predictors Of The Outcome Of Medication Challenges Dr. Farah Khan, DO1,2, Dr. Christopher Chang, MD, PhD, FAAAAI2 and Dr. Gang Ye, PhD3, 1Thomas Jefferson University Hospital, Philadelphia, PA, 2Alfred I duPont Hospital for Children, Wilmington, DE, 3Nemours, Orlando, FL Clinical Experience With Oxaliplatin (O) Desensitization (OD): A Case Series Dr. Adam Updegraff, DO, University of South Florida, Tampa, FL and Dr. Devang R. Doshi, MD, FAAAAI, William Beaumont Hospital, Royal Oak, MI Clinical Value Of a Negative Skin Test To Contrast Radio Media (CR) In Further Exposures Dr. Luiz C G Arcanjo, Dr. Tania M T Gonc¸alves, Flavia C Loyola, Matheus Ribeiro, Alfredo Alves Neto, Tatiana L Carvalho and Dr. Jose Luiz M. Rios, MD, PhD, Policlinica Geral do Rio de Janeiro, Brazil Perioperative Reactions: Are They So Infrequent? Dr. Claude M. Urbain, MD1, Dr. Alberto Lafuente, MD2, Dr. Gracia Javaloyes, MD, PhD1, Dr. Paula Cabrera-Freitag, MD, PhD3, Dr. Juan De La Borbolla Moran, MD4, Dr. M Jose Goikoetxea, Ph.D, MD4, Dr. Rafael Moncada, MD2, Dr. Maria L Sanz, MD, PhD1, Dr. Marta M. Ferrer, MD, PhD, FAAAAI4 and Dr. Gabriel Gastaminza, MD, PhD1, 1Department of Allergy, Clinica Universidad de Navarra, Spain, 2Department of Anesthesia, Clinica Universidad de Navarra, Spain, 3Department of Allergy, Clinica Universidad de Navarra, Spain, Pamplona, Spain, 4Department of Allergy, Clinica Universidad de Navarra, Pamplona, Spain Causes Of Perioperative Allergic Reactions – Our Experience In The Last Two Years Dr. Lourdes Arochena, MD, Mrs. Deborah Hughes, RN, Dr. Bryan N. Fernandes, MD, Dr. Marina Tsoumani, MD and Dr. Susana F. Marinho, MD, PhD, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom Perianesthetic Hypersensitivity Reactions In Latin America Dr. Edgardo J. Jares, MD1, Dr. Ricardo Cardona-Villa, MD2, Prof. Carlos E. Baena-Cagnani, MD3, Dr. Luis Felipe C. Ensina, MD4, Dr. Juan C. Ivancevich, MD5, Dr. Alfredo Arias Cruz6, Dr. Maximiliano

J ALLERGY CLIN IMMUNOL FEBRUARY 2014

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Gomez7, Dr. Mabel Noemi Cuello, MD8, Dr. Paola Toche Pinaud9, Dr. Blanca Maria Morfin-Maciel, MD10, Prof. Alicia De Falco11, Dr. Adolfo Salvatierra12, Dr. Juan F. Schuhl, MD, FAAAAI13, Dr. Ivan Oswaldo Tinoco Moran, MD14, Dr. Susana Barayazarra15, Dr. Andrea Zanacchi15, Prof. Ada Castillo Mendez16 and Dr. Mario Sanchez-Borges, MD, FAAAAI17, 1C.M.P. SA, Buenos Aires, Argentina, 2Universidad de Antioquia, Medellin, Colombia, 3Catholic University of Cordoba, Cordoba, Argentina, 4Universidade Federal de S~ao Paulo, S~ao Paulo, Brazil, 5Division of Immunology, Medical School, Universidad del Salvador, Buenos Aires. Head of the Division of Allergy and Immunology, Clınica Santa Isabel, Buenos Aires, Argentina, 6Hospital Universitario, Monterrey, Mexico, 7Hospital San Bernardo, Salta, Argentina, 8Consultorios San Juan, San Juan, Argentina, 9Clınica Las Condes, Santiago, Chile, 10Hospital Mocel, Mexico City, Mexico, 11Universidad Nacional de La Plata, La Plata, Argentina, 12Fundair, San Luis, Argentina, 13British Hospital, Montevideo, Uruguay, 14Clinica Torre Medica Para La Familia, Machala, Ecuador, 15Nuevo Hospital San Roque, Cordoba, Argentina, 16Hospital Clinico Quirurugico Dr. Salvador Allende, La Habana, Cuba, 17 Clinica El Avila, 6a transversal Altamira, piso 8, consultorio 803, Caracas., Caracas, Venezuela A New In Vitro Flow Cytometry Method For Detection Of Delayed Drug Sensitization To Local Anesthetics. The Lymphocyte Activation Test (LAT) Dr. Massimo Caruso, PhD, FIT AAAAI, Dr. Rosalia Emma, Dr. Raffaella Lizzio and Prof. Riccardo Polosa, MD, PhD, FAAAAI, University of Catania, Catania, Italy Utility Of ICD-9-CM Codes For Identification Of Allergic Drug Reactions Dr. Rebecca Saff, MD, PhD1, Dr. Carlos Camargo Jr., MD, DrPH1,2, Dr. Susan A. Rudders, MD3, Dr. Sunday Clark, MPH, ScD4, Dr. Aidan Long, MD, FAAAAI1 and Dr. Aleena Banerji, MD1, 1Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 3Division of Asthma and Allergy, Department of Pediatrics, Rhode Island Hospital, Alpert School of Medicine at Brown University, Providence, RI, 4Department of Emergency Medicine, Weill Cornell Medical College, New York, NY Vancomycin Use and Vancomycin Resistant Enterococcus Are Increased In Patients With Reported Penicillin Allergy Dr. Vinitha Reddy, MD, Penn State Hershey Medical Center, Hershey, PA and Dr. Faoud T. Ishmael, MD, PhD, FAAAAI, The Pennsylvania State University College of Medicine, Hershey, PA Detection Of Causative Drugs Using Measurement Of Interferon-~awith Quantiferon-TB Gold Test In Severe Drug Allergy: Preliminary Study Dr. Young-Hee Nam, MD1, Dr. Kyeong-Hee Kim, MD2, Dr. Dong Sub Jeon, MD3, Dr. Hye-Won Lee, MD3, Hee-Joo Nam4 and Mr. Soo-Keol Lee, MD5, 1Department of Internal Medicine, College of Medicine, Dong-A University, Busan, South Korea, 2Department of Laboratory Medicine, College of Medicine, Dong-A University, South Korea, 3Department of Internal Medicine, College of Medicine, Dong-A University, South Korea, 4Department of Pharmacy, Dong-A University Hospital, South Korea, 5Dong-A University College of Medicine, Pusan, South Korea Successful Rapid Desensitization To Glatiramer Acetate In a Patient With Multiple Sclerosis Dr. Ekaterini I. Syrigou, PhD, Department of Allergy, ‘‘Sotiria’’ General Hospital, Athens, Greece, Dr. Photis Psarros, Department of Allergy, Athens Naval Hospital ,Greece and Prof. Konstantinos Syrigos, Athens School of Medicine, Greece Hypersensitivity Reaction To Denosumab In Patient With Osteoporosis: Desensitization Methodology Dr. Antonio Foncubierta, MD, PhD MPH1,2, Dr. Diego Gutierrez, MD, PhD3, Dr. Fermin Medina, MD3, Dr. Salvador Fernandez, MD,

Abstracts AB357

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

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Hospital, Daegu, South Korea, 2Department of Internal Medicine,Kyungpook National University School of Medicine, Daegu, South Korea, 3Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea Successful Rapid Induction Of Temporary Drug Tolerance To Colistimethate Sodium Dr. Colleen S. Adkins, MD, University of Alabama, Birmingham, AL and Dr. James Ryan Bonner, MD, FAAAAI, Alabama Allergy & Asthma Center, Birmingham, AL Anaphylactic Reaction During a Folfox Scheme Administration Secondary To Calcium Folinate: A Case Report Dr. Maria Alicia Urena Tavera, MD1, Dr. Miriam Zamora Verduga1, Mrs. Denisse Angel Pereira2, Dr. Ricardo Madrigal-Burgaleta, MD1, Dr. Pilar Berges, MD. PhD.1 and Dr. Emilio AlvarezCuesta1, 1Ramon y Cajal University Hospital, Spain, 2Ramon y Cajal University Hospital, Madrid, Spain Dual Hypersensitivity To Oxaliplatin Revealed Following Rapid Drug Desensitization: A History Of Anaphylaxis and New-Onset Hemolytic Anemia Dr. Jared Silver, MD, PhD1, Dr. Timothy Kyin, MD1 and Dr. Mariana C. Castells, MD, PhD, FAAAAI2, 1Brigham and Women’s Hospital, Boston, MA, 2Division of Rheumatology, Allergy and Immunology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA Oupatient Lenalidomide Desensitization For Delayed Hypersensitivity Reactions In 5 Patients With Multiple Myeloma Dr. Min Jung Lee, MD1, Dr. Paige G. Wickner, MD2, Dr. Robert Schlossman, MD3, Dr. Paul Richardson, MD3, Dr. Jacob Laubach, MD3 and Dr. Mariana C. Castells, MD, PhD, FAAAAI4, 1Brigham & Women’s Hospital, Boston, MA, 2Brigham & Women’s Hospital, Chestnut Hill, MA, 3Dana Farber Cancer Institute, Boston, MA, 4 Division of Rheumatology, Allergy and Immunology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA An Atypical Case Of Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) With Well-Formed Non-Necrotizing Granulomas On Bone Marrow Biopsy Dr. Katie Miro, MD, Rutgers- New Jersey Medical School, Newark, NJ and Dr. Eugenio Capitle, MD, Rutgers-New Jersey Medical School, Newark, NJ Anaphylactic Reaction To Bacitracin Zinc Topical Antibiotic Ointment: A Case Report Dr. Jake D. Lenington, MD, Oregon Health and Science University, Portland, OR, Dr. David R. Scott, MD, Allergy and Asthma Center of Western Colorado and Dr. Anthony Montanaro, MD, FAAAAI, Oregon Health Science University, Portland, OR

Ocular Allergy 5208 Tuesday, March 4th, 2014, 9:45 AM - 10:45 AM 956

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Ocular Surface Disease Index (OSDI) and Pollen Counts (PC) Mr. Spencer H. Luster, STARx Allergy and Asthma Center, Springfield, NJ; University of Pennsylvania, Philadelphia, PA and Dr. Leonard Bielory, MD, FAAAAI, Rutgers University, New Brunswick, NJ; Robert Wood Johnson University Hospital, New Brunswick, NJ Efficacy and Safety Of a New Olopatadine Hydrochloride, 0.77% Ophthalmic Formulation In Patients With Allergic Conjunctivitis Using The Conjunctival Allergen Challenge (CAC) Model (NCT01479374) Gail Torkildsen, Andover Eye Associates, Andover, MA, Thomas Macejko, Apex Eye, Fairfield, OH, Abhijit Narvekar, Alcon Laboratories, Inc., Fort Worth, TX and Mark Bergmann, Apex Eye, Cincinnati, OH

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PhD4, Dr. Maria Jose Fernandez3 and Dr. Juan Luis Anguita, MD5, 1 Servicio Andaluz de Salud: UGC Joaquin Pece, 2Universidad de Cadiz, 3Hospital Universitario Puerta del Mar, 4Hospital Universitario Carlos Haya, 5Complejo Hospitalario de Jaen Patient With Severe Primary Igf-I Deficit and Mecasermine Allergy: Desensitization Methodology Dr. Diego Gutierrez, MD, PhD1, Dr. Antonio Foncubierta, MD, PhD MPH2,3, Alfonso M. Lechuga, MD, PhD1, Dr. Maria Jose Fernandez1, Juan Luis Anguita,MD, PhD4 and Jose Luis Lechuga, MD, PhD3, 1Hospital Universitario Puerta del Mar, 2Servicio Andaluz de Salud: UGC Joaquin Pece, 3Universidad de Cadiz, 4Complejo Hospitalario de Jaen Drug-Induced Anaphylaxis: A Five Year Study In a Third Level Spanish Hospital Maria Elisa Caralli, M.D.1, Sarah Micozzi, M.D.1, Abdonias Rodrıguez Gamboa, M.D.1, Dasha Roa Medellin, M.D.1, Alberto Alvarez-Perea, MD2 and Manuel De Barrio, M.D.1, 1Hospital General Universitario Gregorio Mara~non, Allergy Department, Madrid, Spain, 2Hospital Materno Infantil Gregorio Mara~non, Pediatric Allergy Department, Madrid, Spain Quinolones Allergy In An Allergy Unit. Our Experience In 3 Years Dr. Tamara Fernandez-Teruel1, Gabriela Zambrano, M.D.2, Celia Pinto1, Beatriz Ameiro, M.D.2, Dr. Roberto Pelta1 and Manuel De Barrio1, 1Department of Allergy, Gregorio Mara~non University Hospital, Madrid, Spain., 2Department of Allergy, Gregorio Mara~ non University Hospital, Madrid, Spain., Spain A Successful Desensitization Protocol For Filgrastim Brett Hronek, MD, Washington University School of Medicine, St Louis, MO and Anthony Kulczycki Jr., MD, FAAAAI, Washington University School of Medicine, St. Louis, MO Are Proton Pump Inhibitors(PPI) Naive? A Case Of Drug Reaction With Eosinophilia and Systemic Symptom (DRESS) Secondary To Lansoprazole Dr. Aditya Uppalapati, MD1, Dr. Sindhura Gogineni, MD1, Dr. Sravantika Koneru, MBBS2 and Dr. Ghassan Kamel, MD3, 1St. Louis University, St. Louis, MO, 2Mamata Medical College, 3Saint Louis University, St. Louis Increased Of PCT and CRP In Dress Syndrome By Two Drugs Structurally Unrelated Molecular In The Same Pacient Dr. Rafael A. Perez Arango, Ramon and Cajal University Hospital,Spain Non-Immediate Skin Reactions Due To Antibiotics Gabriela Zambrano, M.D.1, Dr. Tamara Fernandez2, Beatriz Ameiro, M.D.1, Celia Pinto3, Alberto Alvarez-Perea, MD4 and Manuel De Barrio, M.D.5, 1Department of Allergy, Gregorio Mara~ non University Hospital, Madrid, Spain., Spain, 2Hospital general universitario gregorio mara~non, Madrid, Spain, 3Department of Allergy, Gregorio Mara~non University Hospital, Madrid, Spain., 4 Hospital Materno Infantil Gregorio Mara~non, Pediatric Allergy Department, Madrid, Spain, 5Hospital General Universitario Gregorio Mara~ non, Allergy Department, Madrid, Spain Multiple Drug Hypersensitivity Syndrome In Our Allergy Service Dr. Inmaculada Do~ na, MD, PhD, Dr. Maria J Torres, MD, PhD, Dr. Paloma Campo, MD, PhD, Dr. Francisca Gomez, MD, PhD, Dr. Maria Salas, MD, PhD, Ms. Maria Dolores Ruiz, Ms. Maria Auxiliadora Guerrero and Dr. Miguel Blanca, MD, PhD, Allergy Service, Carlos Haya Hospital, Malaga, Spain Desensitization To Anakinra. Case Report Dr. Miriam Zamora Verduga, Dr. Maria Alicia Urena Tavera, Mrs. Denisse Angel Pereira, Dr. Ricardo Madrigal-Burgaleta, MD, Dr. Pilar Berges-Gimeno, PhD and Dr. Emilio Alvarez-Cuesta, MD, PhD, Ramon y Cajal University Hospital, Madrid, Spain Vitamin K Anaphylaxis Confirmed With Skin Test Dr. Min-Hye Kim1,2 and Dr. Jong-Myung Lee, MD1,3, 1Regional Pharmacovigilance Center, Kyungpook National University

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Cytokine Secretion Profiles In The Tears Of Patients With Chronic Allergic Conjunctivitis Dr. Naoko Okada1, Dr. Hiroshi Fujishima2, Dr. Kazumi Fukagawa3, Dr. Akio Matsuda, PhD1, Dr. Hirohisa Saito, MD., PhD.1 and Dr. Kenji Matsumoto, MD, PhD1, 1Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan, 2Department of Ophthalmology, Tsurumi University, 3 Department of Ophthalmology, Keio University School of Medicine Severity and Frequency Of Allergic Conjunctivitis Symptoms Dr. Milton M. Hom, OD FAAO, Private Practice, Azusa, CA, Dr. Dominick Opitz, OD FAAO, Illinois College of Optometry, Chicago, IL, Dr. Justin Kwan, OD FAAO, Marshall B. Ketchum University, Fullerton, CA and Dr. Leonard Bielory, MD, FAAAAI, Robert Wood Johnson University Hospital, New Brunswick, NJ; Rutgers University, New Brunswick, NJ Ocular Symptoms Are Proportionally More Bothersome In Subjects With More Symptoms Of Cat Allergic Rhinoconjunctivitis Dr. Peter Creticos, Associate Professor of Medicine; Johns Hopkins School of Medicine, Johns Hopkins School of Medicine; Division of Allergy & Clinical Immunology, Crownsville, MD, Dr. Stephen Durham, co-author, Imperial College, London, Dr. Margaret Maclennan, co-author, InVentiv Health and Dr. Rod Hafner, PhD, Circassia Ltd, Oxford, United Kingdom Alcaftadine 0.25% Versus Olopatadine 0.2% In Prevention Of Ocular Itching In Allergic Conjunctivitis Eugene B. McLaurin, MD, FACS1, Nicholas P. Marsico, MD, FACS2, Joseph B. Ciolino, MD3, Linda Villanueva, COT4, Julia M. Williams, MA, BS4 and David A. Hollander, MD, MBA4, 1Total Eye Care P.A., Memphis, TN, 2East West Eye Institute, Los Angeles, CA, 3Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, MA, 4Allergan, Inc., Irvine, CA Cetirizine Significantly Relieves Ocular Allergy Symptoms In Subjects With Seasonal Allergic Rhinitis Dr. Mitesh Patel, PharmD1, Dr. Eduardo Urdaneta, MD1, Ms. Kathleen B. Franklin, BSN, RN2, Ms. Xiaoyan Tian, MS3, Dr. MeiMiau Wu, Dr PH4 and Ms. Qiong Du, MS3, 1McNeil Consumer Healthcare, Fort Washington, PA, 2Franklin Consultants, LLC., Phoenixville, PA, 3Johnson & Johnson Consumer Products, China, Shanghai, China, 4J & J Consumer Products, US, Morris Plains, NJ Cetirizine Effectively Relieves Both Ocular Allergy Symptoms and Nasal Allergy Symptoms In Subjects With Seasonal Allergic Rhinitis Dr. Eduardo Urdaneta, MD1, Ms. Xiaoyan Tian, MS2, Dr. MeiMiau Wu, Dr PH3, Ms. Qiong Du, MS2, Ms. Kathleen B. Franklin, BSN, RN4 and Dr. Mitesh Patel, PharmD1, 1McNeil Consumer Healthcare, Fort Washington, PA, 2Johnson & Johnson Consumer Products, China, Shanghai, China, 3J & J Consumer Products, US, Morris Plains, NJ, 4Franklin Consultants, LLC., Phoenixville, PA Automated Evaluation Of Conjunctival Provocation Tests Mr. Torsten Sehlinger1, Mr. Jaron Zuberbier2, Dr. Oliver Kuehlert1, Mr. Frank Goergen1, Prof. Torsten Zuberbier3 and Prof. Karl-Christian Bergmann3, 1Bluestone Technology GmbH, Woerrstadt, Germany, 2Evangelic High-School Kleinmachnow, Germany, 3 Allergy-Centre-Charite, Berlin, Germany

Allergen Immunotherapy 5209 Tuesday, March 4th, 2014, 9:45 AM - 10:45 AM 965

Aeroallergen Immunotherapy Reduces Wheal Diameter In Seasonal and Perennial Allergen Intradermal Skin Tests Mr. Michael Hauk1, Mrs. Barbara A. McGoey, RN1, Mr. Parimal Patel1, Mrs. Nicole Argenzia, RN1 and Dr. Mary Ann Michelis,

J ALLERGY CLIN IMMUNOL FEBRUARY 2014

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MD, FAAAAI2, 1Hackensack University Medical Center, Hackensack, NJ, 2Center for Allergy, Asthma and Immune Disorders Hackensack University Medical Center, Hackensack, NJ Nanoparticle Engineering For The Immunomodulation Of Dendritic Cells Dr. Xavier le Guevel, PhD1, Dr. Tahıa Fernandez, PhD2, Dr. Adrinez, PhD4, Dr. Maria J ana Ariza, PhD3, Dr. Maria Isabel Monta~ Torres, MD, PhD5, Dr. Cristobalina Mayorga, PhD6 and Dr. Miguel Blanca, MD, PhD5, 1Bionand, Campanillas, Spain, 2Research Laboratory - FIMABIS Foundation, Malaga, Spain, 3Research Laboratory for Allergic Diseases, Hospital Regional Universitario de Malaga - FIMABIS-IBIMA, Malaga, Spain, 4Research Laboratory for Allergic Diseases, Hospital Regional Universitario de Malaga - IBIMA, Malaga, Spain, 5Allergy Service, Carlos Haya Hospital, Malaga, Spain, 6Research Laboratory, Carlos Haya Hospital-FIMABIS, Malaga, Spain Specific Immunotherapy Modified T-Cells Responses In a Spanish Population Of Der p Allergic Patients Dr. Tahıa Fernandez, PhD1, Dr. Cristobalina Mayorga, PhD2, Dr. Enrique Gomez3, Mrs. Rosa Garcia4, Mrs. Maria Isabel Sanchez5, Dr. Ana Aranda, PhD2, Ms. Miriam Osorio2, Dr. Miguel Blanca, MD, PhD6 and Dr. Marıa Jose Torres, MD, PhD6, 1Research Laboratory - FIMABIS Foundation, Malaga, Spain, 2Research Laboratory, Carlos Haya Hospital-FIMABIS, Malaga, Spain, 3Research Laboratory of allergic diseases - Carlos Haya Hospital. FIMABIS Foundation. Spain, Malaga, Spain, 4Allergy Service- Carlos Haya hospital. Spain, Malaga, Spain, 5Allergy Service -Carlos Haya Hospital. Spain, 6Allergy Service, Carlos Haya Hospital, Malaga, Spain Efficacy Of 300IR 5-Grass Pollen Sublingual Tablets In Grass Pollen-Associated Allergic Rhinoconjunctivitis: Pooled Analysis By Level Of Pollen Exposure Prof. Alain Didier, MD, PhD1, Prof. Ulrich Wahn, Prof Dr Med2, Mr. Yann Amistani, Msc3 and Dr. Robert K. Zeldin, MD3, 1Larrey Hospital, CHU, Toulouse, France, 2Charite, Berlin, Germany, 3Stallergenes S.A., Antony, France The Print Survey II: Perceptions Regarding Injection Number and Technique Dr. Michael S. Tankersley, MD, FAAAAI1, Dr. Sandy Yip, MD2 and Dr. Christopher A. Coop, MD2, 1Wilford Hall Ambulatory Surgical Center, Joint Base San Antonio, San Antonio, TX, 2Wilford Hall Ambulatory Surgical Center, Lackland AFB, TX Allergy Immunotherapy: Characteristics and Risk Factors For Recurrent Systemic Reactions Kerline Ductan, MD1, Ewa Schafer, MD, FAAAAI2, Rachel E. Story, MD2, Deeba Masood, MD2, Paul Detjen, MD3 and Ying Zhou, PhD4, 1Department of Internal Medicine, University of Chicago-NorthShore, Evanston, IL, 2Allergy and Immunology, NorthShore University HealthSystem (NUHS), IL, 3Kenilworth Medical Allergy & Immunology, Kenilworth, IL, 4Center for Clinical and Research Informatics (CCRI), NUHS Research Institute, Evanston, IL Allergen Specific Immunotherapy In Monosensitized and Polysensitized Allergic Rhinitis Patients Dr. L. Maslova, Republican Scientific and Practical Center for Epidemiology and Microbiology.Minsk, Belarus, Dr. Leonid P. Titov, MD, PhD, Republican Scientific and Practical Center for Epidemiology and Microbiology, Minsk, Belarus and Prof. Lawrence M. DuBuske, MD, FAAAAI, George Washington University School of Medicine, DC The Effect Of The Ragweed Sublingual Immunotherapy Tablet MK-3641 On Rescue Medication Use Dr. Sandra M. Gawchik, DO, FAAAAI1, Dr. Peter S. Creticos, MD, FAAAAI2, Kevin R. Murphy, MD3, Dr. Gary D. Berman, MD, FAAAAI4, Dr. David I. Bernstein, MD, FAAAAI5, Dr. Jennifer Maloney, MD6, Dr. Amarjot Kaur, PhD6 and Dr. Hendrik Nolte, MD, PhD6, 1Asthma and Allergy Associates, Chester, PA, 2Johns Hopkins Division of Allergy & Clinical Immunology, 3Boys Town National

Abstracts AB359

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

Research Hospital, Boys Town, NE, 4Allergy and Asthma Specialists, Minneapolis, MN, 5Bernstein Allergy Group, Cincinnati, OH, 6 Merck, Whitehouse Station, NJ

Basic and Translational Immunology 5602 Tuesday, March 4th, 2014, 2:00 PM - 3:15 PM 978

Asthma Epidemiology and Risk Factors

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Exposures That Alter The Early Life Microbiome and The Risk Of Asthma Amy S. Feldman, MD1, Pingsheng Wu, PhD, MS1,2, Kristina James, MD3, Tebeb Gebretsadik, MPH1,2, Gabriel Escobar, MD4,5, Kecia N. Carroll, MD6, Sherian Xu Li, MS5, Eileen Walsh, RN, MPH5, Ed Mitchel, MS1 and Dr. Tina V. Hartert, MD, MPH7, 1Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, and Center for Asthma and Environmental Sciences Research, Vanderbilt University School of Medicine, Nashville, TN, 2Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, 3Peninsula Allergy & Asthma Center, Soldotna, AK, 4Kaiser Permanente Medical Care Program, Oakland, CA, 5Kaiser Permanente Northern California, Perinatal Research Unit, Division of Research, 6 Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, 7Vanderbilt University School of Medicine, Nashville, TN Ethnic Differences Of Reported Asthma Symptoms In Urban School-Based Screening Surveys Dr. Margee Louisias, MD1, Dr. Joanne Sordillo, ScD2,3, Mrs. Chunxia Fu, MS4,5 and Dr. Wanda Phipatanakul, MD, MS, FAAAAI3,6, 1Brigham and Women’s Hospital, Boston, MA, 2Channing Division of Network Medicine, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, 3Harvard Medical School, Boston, MA, 4Harvard School of Public Health, Boston, MA, 5 Channing Laboratory, Brigham and Women’s Hospital, Boston, MA, 6Boston Children’s Hospital, Boston, MA Year One Daycare Attendance Predicts Asthma At Age Seven: The Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS) Dr. Gang Cheng, MD, PhD1, Linda Levin, PhD2, Dr. Andrew M. Smith, MD, FAAAAI3, Dr. Tolly Epstein, MD, MS4, Patrick Ryan, PhD5, Grace K. LeMasters, PhD2 and Dr. David I. Bernstein, MD, FAAAAI1, 1Division of Immunology Allergy & Rheumatology, University of Cincinnati Medical Center, CINCINNATI, OH, 2University of Cincinnati, Cincinnati, OH, 33255 Eden Ave., HPB 350, University of Cincinnati Medical Center, Cincinnati, OH, 4Allergy Partners of Central Indiana, Indianapolis, IN, 5Cincinnati Children’s Hospital, Cincinnati, OH Determining Risk Levels Of The Composite Asthma Severity Index (CASI) Rebecca A. Zabel1, Dr. Peter J. Gergen, MD, MPH2, Dr. Christine A. Sorkness, PharmD3, Jeremy Wildfire1, Mr. Agustin Calatroni, MA MS1 and Dr. Herman Mitchell, PhD1, 1Rho, Inc., Chapel Hill, NC, 2AAIB\DAIT\NIH, Bethesda, MD, 3University of Wisconsin, Madison, WI BMI and Asthma Severity In An Elementary and Middle School Inner City Population Dr. Christina G. Kwong, MD1, Ms. Christina Mahl, RN2, Ms. Lisa D. Henry, PNP-BC2, Dr. Deborah Loman, PhD, CPNP3, Dr. Robert C. Strunk IV, MD, FAAAAI1, Ms. Lisa A. Meadows, PNP-BC2 and Dr. Alysa G. Ellis, MD1, 1Washington University School of Medicine, Saint Louis, MO, 2St. Louis Children’s Hospital, Saint Louis, MO, 3St. Louis University School of Nursing, Saint Louis, MO

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Environmental Risk Factors and Diseases Outcomes 5603 Tuesday, March 4th, 2014, 2:00 PM - 3:15 PM 983

Effect Of Prenatal Exposure To Indoor PM2.5 and Environmental Tobacco Smoke Affecting Lower Respiratory Tract Infection Was Modified By ROS Genes: Cocoa Study Dr. Song I Yang, MD1, Dr. Eun Lee, MD1, Dr. Young Ho Jung, MD1, Kil-Yong Choi2, Mi-Jin Kang, MS2, Ho-Sung Yu2, Cheol Min Lee3, Prof. Youn Ho Shin, MD, PhD4, Prof. Kangmo Ahn, MD, PhD5, Prof. Kyung Won Kim, MD, PhD6, Prof. Soo-Jong Hong, MD, PhD1 and Cocoa study Group7, 1Childhood Asthma Atopy Center, Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea, 2Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, South Korea, 3Institute of Environmental and Industrial Medicine, Hanyang University, Seoul, South Korea, 4Department of Pediatrics, CHA Medical Center, CHA University College of Medicine, Seoul, South Korea, 5Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 6Department of Pediatrics, Yonsei University College of Medicine, Seoul, South Korea, 7COCOA study group

TUESDAY

5601 Tuesday, March 4th, 2014, 2:00 PM - 3:15 PM

Novel NK Cytotoxicity Assay Enables Drug Discovery For Hemophagocytic Lymphohistiocytosis Dr. Jinzhu Li, MD, PhD, Ms. Sarah E. Figueira, Ms. Julie Ferrel and Dr. Kimberly A. Risma, MD, PhD, FAAAAI, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH Exploitation Of The Host Ubiquitin System By Respiratory Syncytial Virus Nonstructural Protein 2 Jillian N. Whelan1, Kim C. Tran1, Ruan R. Cox Jr.1, Damian B. van Rossum2, Randen L. Patterson2 and Michael Teng1, 1Division of Allergy and Immunology, Department of Internal Medicine, and the Joy McCann Culverhouse Airway Diseases Research Center, University of South Florida Morsani College of Medicine, Tampa, FL, 2The Pennsylvania State University, University Park, PA Epigenetic Regulation Of Dendritic Cell Migration Dr. Timothy P. Moran, MD, PhD1, Dr. Hideki Nakano, PhD2, Dr. Hrisavgi Kondilis-Mangum, PhD2, Dr. Paul Wade, PhD2 and Dr. Donald Cook, PhD2, 1Duke University Medical Center, Durham, NC, 2National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC LRBA Subcellular Localization: Evidence Of The LRBA’s Role In Vesicle Trafficking From The Golgi To Cell Membrane and Endocytosis Mrs. Michelle A. Reiser, MS1, Dr. Jia-Wang Wang, PhD1, Mrs. Kunyu Li, BS1 and Dr. Richard F. Lockey, MD2, 1Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida, Morsani College of Medicine, Tampa, FL, 2 Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine and James A. Haley Veterans’ Affairs Hospital, Tampa, FL Differential Role Of Dendritic Cell Subsets In Shaping T-Cell Responses To Respiratory Viruses Dr. Meera Rani Gupta, M.D., Dr. Deepthi Kolli, PhD, Dr. Antonella Casola, M.D. and Dr. Roberto P. Garofalo, MD, University of Texas Medical Branch, Galveston, TX

149

AB360 Abstracts

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IgE Anti-Respiratory Syncytial Virus Antibodies In Older Asthmatic Children Mira Mandal1, Dr. Rauno O. Joks, MD, FAAAAI2, Dr. Kevin Norowitz, M.D.3, Dr. Diana Weaver, MD4, Dr. Helen G. Durkin, PhD5, Dr. Martin H. Bluth, MD, PhD6, Dr. Stephan Kohlhoff, MD5 and Dr. Tamar A. Smith-Norowitz, PhD7, 1SUNY Downstate Medical Center, 2 SUNY-HSC, Brooklyn, NY, 3SUNY Downstate Medical Center, Center for Allergy and Asthma Research, Brooklyn, NY, 4SUNY Downstate Med. Ctr, Brooklyn, NY, 5Center for Allergy and Asthma Research, State University of New York Downstate Medical Center, Brooklyn, NY, 6Wayne State University Medicine, Detroit, MI, 7Center for Allergy and Asthma Research at SUNY Downstate, Brooklyn, NY Asthma Symptoms and Rhinovirus In A Longitudinal Children’s Cohort Dr. Euan R. Tovey, PhD1,2, Dr. S. Stelzer-Braid, PhD3,4, Dr. B.G. Toelle, PhD1, Ms. C.M. Willenborg, BSc3, Dr. H.K Reddel, PhD, MBBS1,2, Ms. F.L. Garden, MPH1,2, Prof. A. Jaffe, PhD MD4,5, Ms. R. Strachan5, Dr. B.G. Oliver, PhD1,2, Dr. Y.C. Belessis, MBBS4,5, Prof. G.B. Marks, PhD, MD1,2 and Prof. W.D. Rawlinson, PhD, MD3,4, 1Woolcock Institute of Medical Research, Sydney, Australia, 2 University of Sydney, Australia, 3Virology Division, SEALS Microbiology, Prince of Wales Hospital, Sydney, Australia, 4University of NSW, Australia, 5Sydney Children’s Hospital, Randwick Australia Maternal Transfer Of Der p 1 and Blo t 5 Allergens and Their Respective Specific Antibodies Trough Placenta and Colostrum Dr. Patricia Macchiaverni, Department of Immunology, Institute of Biomedical Sciences, University of S~ao Paulo, SP, Brazil, Christina Arslanian, University of S~ao Paulo, Dr. Valerie Verhasselt, INSERM, Valbonne, France and Prof. Antonio Condino-Neto, MD, PhD, Institute of Biomedical Sciences, Department of Immunology, University of S~ao Paulo, Sao Paulo, Brazil Rhinovirus Infection Is Associated With Changes In The Airway Microbiome Dr. Kirsten Kloepfer, MD1, Dr. Valeriy Poroyko, PhD2, Mrs. Rose Vrtis, BS3, Mrs. Tressa Pappas, BS3, Dr. Theresa Kang, PhD3, Dr. Wai-Ming Lee, PhD3, Mr. Michael D. Evans, MS3, Dr. Ronald E. Gangnon, PhD3, Dr. Yury Bochkov, PhD3, Dr. Robert F. Lemanske Jr., MD, FAAAAI3 and Dr. James E. Gern, MD, FAAAAI3, 1Riley Hospital for Children at Indiana University Health, Indianapolis, IN, 2University of Chicago, Chicago, IL, 3University of Wisconsin School of Medicine and Public Health, Madison, WI

J ALLERGY CLIN IMMUNOL FEBRUARY 2014

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Population Health and Food Allergy 5605 Tuesday, March 4th, 2014, 2:00 PM - 3:15 PM 993

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Eosinophilic Gastrointestinal Diseases 5604 Tuesday, March 4th, 2014, 2:00 PM - 3:15 PM 988

TUESDAY 150

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Natural History Of Esophageal Remodeling In Pediatric Eosinophilic Esophagitis Treated For Four Years Dr. Jessica Rajan, MD1,2, Dr. Robert Newbury, MD3,4, Arjun Andrew Anilkumar, BS2,5, Ranjan Dohil, MD6,7, Dr. David H. Broide, MB ChB FAAAAI8 and Seema Sharma Aceves, MD, PhD, FAAAAI9, 1Scripps Clinic Medical Group, San Diego, CA, 2Division of Allergy/Immunology, 3Department of Pediatrics, 4Division of Pathology, 5Department of Medicine, 6Department of Pediatrics, Division of Gastroenterology, 7 Division of Gastroenterology, UCSD, Rady Children’s Hospital, San Diego, 8Department of Medicine, San Diego, CA, 9Pediatrics, University of California San Diego, La Jolla, CA Diagnostic Inaccuracy Of Biopsy Evaluations In Eosinophilic Esophagitis Underscores The Value Of a Secondary Review Process Emily Stucke, BA1, Dr. Katherine E. Clarridge, MD, MSc1,2, Dr. Margaret Collins, MD1, Dr. Lisa J. Martin, PhD1, Carol J. Henderson, PhD RD LD1 and Dr. Marc E. Rothenberg, MD, PhD, FAAAAI1, 1Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2University of Cincinnati

Development Of Eosinophilic Esophagitis To Food After Development Of IgE Tolerance To The Same Food Dr. Solrun Melkorka Maggadottir, MD1, Dr. David Hill, MD, PhD2, Dr. Terri F. Brown-Whitehorn, MD1 and Dr. Jonathan M. Spergel, MD, PhD, FAAAAI3, 1Children’s Hospital of Philadelphia, Philadelphia, PA, 2Children!s Hospital of Philadelphia, 3The Children’s Hospital of Philadelphia, Philadelphia, PA Mast Cells, Eosinophils and Eosinophilic Esophagitis Dr. Jay Jin, MD, PhD, Dr. Jeffrey Alexander, MD, Hirohito Kita, MD, Ms. Diane Squillace, MS, Dr. Joseph A. Murray, MD, Dr. Amindra Arora, MD, Dr. Yvonne Romero, MD, Dr. Thomas Smyrk, MD and Dr. Catherine R. Weiler, MD, PhD, FAAAAI, Mayo Clinic, Rochester, MN CD3 and CD8 Cells Produce IL-9 In Pediatric Eosinophilic Esophagitis Arjun Andrew Anilkumar, BS, Department of Medicine; Division of Allergy/Immunology, Lisa Beppu, BS, Department of Pediatrics University of California San Diego; Division of Allergy and Immunology, Richard Kurten, PhD, University of Arkansas for Medical Sciences, Little Rock, AR; Department of Physiology and Biophysics, Dr. Robert Newbury, MD, Department of Pediatrics; Division of Pathology, Ranjan Dohil, MD, Department of Pediatrics, Division of Gastroenterology; Division of Gastroenterology, UCSD, Rady Children’s Hospital, San Diego, David Broide, MB ChB, University of California San Diego, Department of Medicine, Division of Allergy and Immunology and Seema Sharma Aceves, MD, PhD, FAAAAI, Pediatrics, University of California San Diego, La Jolla, CA

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Longitudinal Effect Of Food Allergy Education On Epinephrine Availability In Public Schools Dipika Patel, MD1, Gwendolyn Johnson, BSN, RN, MEd2, Danielle Guffey, MS1, Charles Minard, PhD1 and Carla Davis, MD1, 1Baylor College of Medicine, Houston, TX, 2Houston Independent School District, Houston, TX Population Response To Change In Infant Feeding Guidelines For Allergy Prevention Dr. Dean Tey, MD1,2, Prof. Katrina Jane Allen, MD, PhD, FAAAAI1,2, Ms. Rachel Peters, MPH2, Dr. Jennifer Koplin, PhD2, Prof. Mimi L. K. Tang, MD, PhD, FAAAAI3, Prof. Lyle Gurrin, PhD2,4, Prof. Anne-Louise Ponsonby, PhD2, Dr. Adrian Lowe, PhD2,4, Prof. Melissa Wake, MD, PhD1,2 and Prof. Shyamali Dharmage, MD, PhD2,4, 1Royal Children’s Hospital, Victoria, Australia, 2 Murdoch Childrens Research Institute, Victoria, Australia, 3The University of Melbourne, Melbourne, Australia, 4University of Melbourne, Victoria, Australia Teasing and Bullying Among Adolescents With Food Allergy Dr. Adora Lin, MD, PhD, National Institute of Allergy and Infectious Diseases, Bethesda, MD and Dr. Hemant P. Sharma, MD MHS FAAAAI, Children’s National Medical Center, Division of Allergy and Immunology, Washington, DC Differences In Food Allergy Quality Of Life Between Caregivers In a Clinic-Based and a Caregiver-Reported Food Allergic Population Dr. Matthew J. Greenhawt, MD, MBA, MSc, Department of Internal Medicine, The University of Michigan Medical School, Division of Allergy and Clinical Immunology, Ann Arbor, MI Food Allergy Management In An Urban Pediatric Population Dr. Jennifer M. Camacho, MD, Dr. Stephanie Albin, MD, Dr. Doerthe A. Andreae, MD and Dr. Julie Wang, MD, FAAAAI, The Icahn School of Medicine at Mount Sinai, New York, NY

Abstracts AB361

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

Parronchi1, 1University of Florence, DENOTHE Center, Florence, Italy, 2University of Florence, Dept. of Chemistry ‘‘U. Shiff’’, Florence, Italy, 3University of Florence, Mass Spectrometry Center (CISM), Florence, Italy

New Forms of Immunotherapy 5606 Tuesday, March 4th, 2014, 2:00 PM - 3:15 PM 998

Mechanisms of T Cell-Mediated Allergic Disease 5607 Tuesday, March 4th, 2014, 2:00 PM - 3:15 PM 1003

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TSLP Induces Corticosteroid Resistance In Natural Helper Cells Via STAT5 Pathway Hiroki Kabata1, Kazuyo Moro2,3, Koichi Fukunaga1, Yusuke Suzuki1, Katsunori Masaki1, Tomoko Betsuyaku1, Shigeo Koyasu1,2 and Prof. Koichiro Asano, MD4, 1Keio University School of Medicine, Tokyo, Japan, 2RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan, 3PRESTO, JST, Japan, 4Tokai University School of Medicine, Kanagawa, Japan Impairment Of IL-27’s Differential Effect On CD4+T Cells In Asthma Dr. Zhihong Chen1, Shanze Wang2, Xiaopeng Qi2, Prof. Chunxue Bai1 and Prof. Hua Huang2, 1Zhongshan Hospital, Fudan University, Shanghai, China, 2National Jewish Health, Denver, CO Profile Of Food Allergen-Specific T Cells In Allergic and Clinically Tolerant Individuals David Chiang, MS1, Alexander V. Grishin, PhD1, Madhan Masilamani, PhD1, Miriam Merad, MD, PhD1, A. Karolina Palucka, MD, PhD1,2, Hideki Ueno, MD, PhD2, A. Wesley Burks, MD, FAAAAI3, Stacie M. Jones, MD4, Andrew H. Liu, MD5, Scott H. Sicherer, MD, FAAAAI1, Robert A. Wood, MD, FAAAAI6, Wendy Davidson, PhD7, Hugh A. Sampson, MD, FAAAAI8 and M. Cecilia Berin, PhD1, 1Icahn School of Medicine at Mount Sinai, New York, NY, 2Baylor Institute for Immunology Research, Dallas, TX, 3University of North Carolina, Chapel Hill, NC, 4University of Arkansas for Medical Sciences and Arkansas Children’s Hospital, Little Rock, AR, 5National Jewish Health, Denver, CO, 6 Johns Hopkins University Medical Center, Baltimore, MD, 7National Institutes of Health, Bethesda, MD, 8Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY Follicular Helper T Cells Mediate IgE Antibody Production and Allergic Immune Responses in Mice Takao Kobayashi, PhD1, Koji Iijima, PhD1 and Hirohito Kita, MD2, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic Rochester, Rochester, MN Analysis Of Circulating Rhinovirus-Specific CD4+ T Cells Using Novel MHC Class II Tetramers Reveals Marked Expansion Of Effector Memory Cells In Infected Subjects Lyndsey Muehling1, Rachana Agrawal, PhD1, Julia Wisniewski, MD1, Paul Wright1, William W. Kwok, PhD2, Ronald Turner, MD1 and Judith A. Woodfolk, MBChB, PhD, FAAAAI1, 1 University of Virginia Health System, Charlottesville, VA, (2)Benaroya Research Institute at Virginia Mason, Seattle, WA

TUESDAY

Persistent Treatment Effect Achieved At One Year After Four Doses Of Der p Derived Synthetic Peptide Immuno-Regulatory Epitopes In An Exposure Chamber Model Of House Dust Mite Allergy Dr. Rod Hafner, PhD1, Dr. Peter Couroux, M.D.2, Ms. Kristen Armstrong, M.Sc.3, Dr. AnneMarie Salapatek, PhD4, Dr. Deepen Patel, M.D.2 and Dr. Mark Larche, PhD5, 1Circassia Ltd, Oxford, United Kingdom, 2Topstone Research, Toronto, ON, Canada, 3 Adiga Life Sciences Inc., Hamilton, ON, Canada, 4Inflamax Research, Mississauga, ON, Canada, 5McMaster University/St. Joseph’s Healthcare, Hamilton, ON, Canada 999 Treatment With Synthetic Peptide Immuno-Regulatory Epitopes Derived From Grass Allergens Leads To a Substantial Reduction In Grass Allergy Symptoms In The Environmental Exposure Unit Dr. Anne K. Ellis, MD, MSc FAAAAI1,2, Dr. Charles W. Frankish, MD3, Ms. Kristen Armstrong, M.Sc.4, Dr. Mark Larche, PhD5, Ms. Lisa Steacy, BSc1 and Dr. Rod Hafner, PhD6, 1Allergy Research Unit, Kingston General Hospital, Kingston, ON, Canada, 2Departments of Medicine and Biomedical & Molecular Science, Queen’s University, Kingston, ON, Canada, 3Kanata Allergy Services, Kanata, ON, Canada, 4Adiga Life Sciences Inc., Hamilton, ON, Canada, 5McMaster University/St. Joseph’s Healthcare, Hamilton, ON, Canada, 6Circassia, Oxford, United Kingdom 1000 Epicutaneous Immunotherapy Induces Epigenetic Changes In Sensitized Mice Lucie Mondoulet, PhD1, Dr. Vincent Dioszeghy, PhD1, Mrs. Melanie Ligouis1, Mrs. Veronique Dhelft1, Mrs. Emilie Puteaux1, Mrs. Camille Plaquet1, Prof. Christophe Dupont, MD, PhD2 and Pierre Henri Benhamou, MD1, 1DBV Technologies, Bagneux, France, 2Hopital Necker Enfants Malades, Paris, France 1001 Ultra-Fast Hypoallergenic Birch Pollen Allergy Vaccine Allert Is Efficient and Safe: Results Of a Phase IIb Study Dr. Francois Spertini, MD1, Prof. Frederic de BLAY2, Dr. Lars Jacobsen, MD3, Prof. Marek Jutel, MD, PhD4, Dr. Margitta Worm, MD5, Dr. Gilles Della Corte, MD6, Dr. Alexander Kettner, PhD7, Dr. Vincent Charlon, PhD6 and Dr. Christophe Reymond7, 1 Division of Immunology and Allergy, CHUV, LAUSANNE, Switzerland, 2CHRU Strasbourg, France, 3Glostrup University Hospital, Copenhagen, Denmark, 4Wroclaw Medical University, Wroclaw, Poland, 5Charite - Universit€atsmedizin Berlin, Berlin, Germany, 6Anergis SA, Epalinges, Switzerland, 7ANERGIS SA, EPALINGES, Switzerland 1002 Stable Conjugates Between A Novel Toll-Like Receptor 7 Ligand and Protein Allergens As Modulators Of Th2 Responses In Vitro and In Vivo Dr. Lucia Fil"ı1, Dr. Alessandra Vultaggio1, Dr. Elisa Cardilicchia1, Dr. Cinzia Manuelli1, Dr. Andrea Casini2, Dr. Francesca Nencini1, Dr. Laura Maggi1, Dr. Sara Pratesi1, Dr. Giulia Petroni1, Dr. Francesca Boscaro3, Prof. Ernesto Giovanni Occhiato2, Prof. Sergio Romagnani1, Prof. Enrico Maggi1 and Prof. Paola

151

AB398 Abstracts

J ALLERGY CLIN IMMUNOL FEBRUARY 2014

LATE-BREAKING ABSTRACTS PRESENTED AT SCIENTIFIC SESSIONS AAAAI ANNUAL MEETING FEBRUARY 28-MARCH 4, 2014 The following abstracts were accepted for presentation after the deadline for the abstract supplement

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Human TNFR2 Exhibits Bi-Directional Control over Regulatory T Cells Dr. Denise L. Faustman, MD, PhD1, Limei Wang2, Yoshiaki Okubo2; 1 Massachusetts General Hospital/Harvard Medical, Charlestown, MA, 2 Massachusetts General Hospital/Harvard Medical. BACKGROUND: The homeostatic functions of CD4+ regulatory T-cells (Treg) protect against autoimmunity, cancer and infections, but mechanisms governing Treg activity are ill-defined. We hypothesized that tumor necrosis factor receptor 2 (TNFR2) may control Treg functions, considering that TNFR2 is highly expressed on human Tregs. METHODS: Effects of TNFR2 monoclonal antibodies (moAbs) on Treg proliferation, signaling, phenotype, and function were studied by multiple in vitro assays using isolated fresh human CD4+ and CD25hi coexpressing T cells from >100 donors. Antibody performance was compared to standard Treg expansion methods and categorized as agonist, antagonist or neutral in activity. RESULTS: Two antibodies exclusively acted as either a TNFR2 agonist or antagonist. In vitro the newly identified TNFR2 agonist induced proliferation of enriched human Tregs into phenotypically homogeneous populations of effector Tregs (FOXP3hiCD45RO+CD25hiHLADR+CTLA4+,CD127-CXCR3-). Conversely, the TNFR2 antagonist suppressed human Treg proliferation. When Tregs were co-incubated with their target CD8+ T-cells, the agonist-treated Tregs suppressed CD8+ proliferation, whereas the antagonist had negligible effects. The two ligands also triggered different downstream intracellular Treg signaling, with the agonist upregulating TRAF2, FOXP3 and cIAP2. CONCLUSIONS: The findings show that certain TNFR2 ligands can act as antagonists or agonists by exerting opposing actions in human cells regarding Treg proliferation, signaling, and target cell activity. TNFR2 has the potential for bidirectional control over Treg homeostatic functions in humans, opening new clinical opportunities for Treg expansion or suppression.

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Contribution of Sequential and Conformational IgE-Binding Epitopes to the Allergenicity of Major Peanut Allergen Ara h 2 Stephane Hazebrouck, PhD1, Blanche Guillon, BSc1, Marie-Franc¸oise Drumare, BSc1, Evelyne Paty, MD2, Jean-Michel Wal, PhD1, Herve Bernard, PhD1; 1INRA UR496, Gif-sur-Yvette, France, 2Universite Paris Descartes, H^ opital Necker Enfants Malades, Paris, France. RATIONALE: Protein unfolding reduces significantly the allergenic activity of the most potent peanut allergen Ara h 2. This allergen also contains major sequential IgE-binding epitopes, especially in a flexible region comprising the repetitive post-translationally modified peptide DPYSPOHS, with a hydroxyproline (HYP). We then investigated the relative contributions of sequential and conformational epitopes to the allergenic activity of Ara h 2. METHODS: Peptides overlapping the HYP-domain were synthesized with or without the prolines hydroxylated. A variant lacking the HYP-domain was generated by deletion mutagenesis. IgE reactivity of 19 peanut-allergic patients toward synthetic peptides and recombinant Ara h 2 variants was determined by IgE-binding inhibition assays and by degranulation tests of rat basophil leukemia (RBL) SX38 cells sensitized with patients’ IgE antibodies. RESULTS: The peptide encompassing the longest HYP-domain exhibited an inhibitory capacity similar to that of the full-length unfolded Ara h 2, but

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only when prolines were hydroxylated. Deletion of the HYP-domain did not prevent the variant to refold correctly and to display Ara h 2 conformational epitopes. The IgE-binding capacity of Ara h 2 was then recapitulated with an equimolar mixture of the deletion variant and the synthetic HYP-peptide. Surprisingly, the HYP-peptide was also able to trigger the degranulation of RBL cells as efficiently as the unfolded Ara h 2, which retained an allergenic activity with most of the tested sera. CONCLUSIONS: Proline hydroxylation is critical for Ara h 2 allergenicity and peptides overlapping the HYP-domain, as short as 15 and 27 amino acid residues, retain an anaphylactic potential.

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Immunocap Cellulose Displays Cross-Reactive Carbohydrate Epitopes and Can Cause False-Positive Test Results in Patients with Anti-CCD IgE Antibodies Wolfgang Hemmer, PhD1, Stefan Wohrl, MD, MSc, FAAAAI1, Felix Wantke, MD, FAAAAI1, Friedrich Altmann, PhD2; 1Floridsdorf Allergy Center, Vienna, Austria, 2Department of Chemistry, University of Natural Resources and Life Sciences, Vienna, Austria. RATIONALE: Cross-reactive carbohydrate determinants (CCDs) in plant and insect venom extracts are a common cause of false-positive results during in vitro allergy diagnosis. We noticed, when using the Phadia ImmunoCAP system, that some CCD-positive sera deliver multiple positive results even when tested with CCD-free recombinant allergens. METHODS: ImmunoCAP IgE binding to selected recombinant allergens and to blank ImmunoCAPs (BIC) with no allergens coupled to the cellulose sponge was compared in CCD-positive sera before and after inhibition with a CCD inhibitor (ProGlycAn, Vienna, Austria). RESULTS: 30/45 (67%) CCD-positive sera (MUXF-CCD 1.01-59.6 kU/l) showed IgE-binding to BIC greater than 0.35 kU/l (0.41-6.66 kU/l). Among those with anti-CCD IgE levels >7.0 kU/l, 86% (24/28) were positive. IgE-binding to BIC correlated with IgE-binding to MUXF-CCD (r50.66) and was completely abolished by serum pre-incubation with a CCD inhibitor (n511). Binding scores with a second lot of BIC were lower but correlated strongly with the first lot (r50.99). IgE-binding of seven highly CCD-reactive sera (14.0-52.5 kU/l) to the recombinant allergens rPhl p12, rFel d1, rAra h2, and rPru p3 was positive to all four components (up to 1.6 kU/l). Binding correlated strongly with antibody binding to MUXF-CCD and BIC (r50.92) and could be completely blocked by the CCD inhibitor. Mass spectroscopic analysis confirmed the presence of MMXF glycans in unprocessed and processed cellulose. CONCLUSIONS: Cellulose used as an allergen carrier in the ImmunoCAP system contains varying traces of CCDs itself, which can cause multiple false-positive results even to non-glycosylated recombinant components in patients with elevated levels of anti-CCD IgE antibodies.

Abstracts AB399

J ALLERGY CLIN IMMUNOL VOLUME 133, NUMBER 2

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The RNA-Binding Protein Hur Is Required to Control Cytokine Expression in CD4+ T Cells Dr. Ulus Atasoy, MD, FAAAAI1, Dr. Patsharaporn Techasintana2, Dr. Joseph Magee2, Dr. Matt Gubin3, Mr. Joe Rowles2; 1Surgery, University of MO-Columbia, Columbia, MO, 2University of Missouri, 3 Washington University. RATIONALE: During T cell activation, up to 50% of changes occur at the posttranscriptional level, which is mediated by RNA-binding proteins (RBPs). HuR is a stabilizing RBP which regulates mRNA target expression via AU-rich elements present in mRNA 3’UTRs. It is permissive for Th2 and Th17 differentiation. METHODS: Previously, we showed HuR regulates GATA-3, IL-4, IL-13 and other Th2 restricted transcripts, as well as IL-17. We hypothesized that HuR is required for Th2 differentiation and Th2 associated disease such as asthma. To avoid defects in T cell development, we utilized a HuR KO mouse model in which HuR is ablated in mature CD4+ T cells, using distal Lck-Cre-ROSA-HuRfl/fl. RESULTS: Activated or Th2 polarized HuR KO CD+4 T cells showed striking increases in IL-2 secretion and an inability to shut off IL-2 expression. These also mice had profound reductions in Th2 and Th17 cytokine expression. We used the ova challenge model of airway inflammation to further investigate HuR KO under antigenic conditions. HuR KO mice had profound reductions in BAL IL-4 and IL-13, and in pulmonary cellular infiltration with suppression of neutrophils, lymphocytes and eosinophils. The levels of cellular infiltration in HuR KO mice resembled un-immunized controls. CONCLUSIONS: HuR appears to be required for Th2 and Th17 but not Th1 differentiation and cytokine production. Furthermore, HuR functions as an off switch for IL-2 expression during T cell activation. These results may have implications for understanding mechanisms of tolerance under antigen challenge as well as in allergen driven airway lung inflammation.

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Whole-Exome Sequencing Reveals IKBKB As a Cause of Combined Immunodeficiency Dr. Talal Mousallem, MD1,2, Dr. Jialong Yang, PhD1, Dr. Thomas J. Urban, PharmD, PhD2, Mrs. Hongxia Wang, MS1,3, Mrs. Roberta E. Parrott, BS1, Dr. Joseph L. Roberts, MD, PhD1, Dr. Rebecca H. Buckley, MD, FAAAAI1, Dr. Xiaoping Zhong, MD, PhD1, Dr. David B. Goldstein, PhD2; 1Department of Pediatrics, Duke University Medical Center, Durham, NC, 2Center for Human Genome Variation, Duke University Medical Center, Durham, NC, 3Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, China. RATIONALE: There is considerable interest in the use of next generation sequencing to identify molecular defects in patients with primary immunodeficiency. METHODS: To identify the cause of Combined Immunodeficiency in 2 patients from 2 different consanguineous Qatari families who had a similar clinical and immunologic phenotype, we used whole-exome sequencing. The patients presented at an early age with fungal, viral and bacterial infections. The patients had hypogammaglobulinemia, normal numbers of B and T cells (most of which were CD45RA positive) and low numbers of NK cells. T cell proliferative responses to mitogens were normal, but were absent to antigens and anti-CD3. We looked for homozygous variants that were present in the patients but absent in controls and public databases. Additional studies included IKKb, IKBa, and phospho-IKBa immunoblotting, retroviral mediated reconstitution of IKKb, and cell growth in an immortalized patient B cell line. RESULTS: We found the same homozygous nonsense mutation in IKBKB (R286X) in both patients. IKKb acts as part of the IKK complex in NF-kB activation and phosphorylates the NF-kB inhibitor, IKBa. The mutation co-segregated with disease in both families. Western blotting showed absence of detectable IKKb, and retroviral mediated reconstitution with wild type IKKb corrected cell growth and restored IKBa phosphorylation and IKBa degradation in an EBV transformed patient B cell line. CONCLUSION: These data indicate that mutated IKBKB is the likely cause of immunodeficiency in these two patients. To our knowledge, this is the first report of combined immunodeficiency caused by a mutation in IKBKB.

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Sputum Cytokines and Adult Asthma Endotypes uckert3, Dr. Ioana O. Agache1, Dr. Costel Agache2, Mrs. Beate R€ 1 2 Prof. Liliana Rogozea , Dr. Cristina Ciobanu , Prof. Cezmi A. Akdis, MD, FAAAAI4; 1Transylvania University Brasov, Romania, 2Theramed Medical Center, Romania, 3Swiss Institute of Allergy and Asthma Research, Switzerland, 4Swiss Institute of Allergy and Asthma Research, Davos, Switzerland. RATIONALE: Asthma clusters can be separated according to their endotype by combining visible properties and sputum cytokines. METHODS: The Local Ethics Committee approved the study. Induced sputum sampled outside an exacerbation was processed by dialysis (D-Tube Dialyzers Midi, Novagen) followed by ultrafiltration (Amicon Ultra 3K, Millipore, 3000 NMWL). Sputum cytokines were measured with the 27 Plex Human Cytokine Group I Bioplex (Biorad). Hierarchical cluster analysis with a wide array of variables was used. Difference between clusters was assesed by One-way Anova. RESULTS: 60 adult asthmatics, mean age 44614 years old, 52% females were included. Three clusters were separated, significantly different for all sputum cytokines (except RANTES and FGF-b), asthma severity (GINA), onset of asthma, ACT score, lung function (LF), AHR, exacerbation frequency, near-fatal asthma (NFA), corticosteroid-resistance, blood eosinophils. Cluster 1 (n527, 67% males) had the lowest frequency of asthma exacerbations, the best LF, predominant macrophages and lymphocytes in induced sputum and the highest sputum IL-4, IL-1RA, VEGF and IL-7. Cluster 2 (n514, 64.3% females) had the longest asthma duration, the highest AHR and frequency of asthma exacerbations, corticosteroid-resistance and NFA, the worst LF and ACT score, the highest sputum and blood eosinophilia and the highest sputum cytokines. Cluster 3 (n519, 63.2% females), had the shortest asthma duration, the highest FeNO and total serum IgE, the highest incidence of LF decline and atopy, sputum neutrophilia and the lowest values for all sputum cytokines. CONCLUSION: Deep phenotyping incorporating phenotypic traits, longitudinal data and biomarkers of inflammation stratifies asthma into subclasses according to their biological basis.

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Omalizumab Therapy Is Associated with Reduced Circulating Basophil Populations in Asthmatic Children Dr. David A. Hill, MD, PhD1, Dr. Mark Siracusa, PhD2, Kathryn Ruymann1, Dr. Elia Tait Wojno, PhD2, Dr. David Artis, PhD2, Dr. Jonathan M. Spergel, MD, PhD, FAAAAI1; 1The Children’s Hospital of Philadelphia, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA. RATIONALE: Basophils have been implicated in promoting the early development of TH2 cell responses in some murine models of TH2 cytokine-associated inflammation. However, the specific role of basophils in allergic asthma remains an active area of research. Recent studies in animal models and human subjects suggest that IgE may regulate the homeostasis of human basophil populations. Here, we examine basophil populations in children with severe asthma before and during therapy with the IgE directed monoclonal antibody omalizumab. METHODS: Subjects were selected based on age between 5 and 18 years, body weight and IgE level compatible with the omalizumab dosing table, and severe asthma. Asthma symptoms assessments were administered during therapy. Peripheral blood samples were obtained before and during therapy and basophil frequencies and numbers were monitored using flow cytometric techniques. RESULTS: Omalizumab therapy was associated with a significant reduction in circulating basophil frequencies and numbers (p