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Allergy to codeine
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Can You Become Addicted to Heroin the First Time?. Seeking addiction treatment can feel overwhelming. We know the struggle, which is why we're uniquely qualified to help. How Long Does Codeine Stay In Your System. Some of the general side effects of codeine can include feeling dizzy or lightheaded, nausea, vomiting, shortness of breathing, sedation, constipation, and itching. There are also serious but rare side effects possible like respiratory depression and severe low blood pressure. People may also experience a codeine allergy. It's not uncommon for people to experience allergic reactions to various medications, and it can be a hereditary trait. This means that if your parents or grandparents have a codeine allergy, you may be at a higher risk of this as well. However, while a codeine allergy is certainly possible, there are also many people who think they have a codeine allergy when they're really only experiencing the side effects of the drug itself. For example, itchiness is a common codeine side effect, and it's also a side effect of other opioid drugs as well. It's not indicative of a codeine allergy. Nor are other symptoms like blurred vision or constipation. These are all just normal symptoms of using codeine. Codeine Allergy Reaction, Symptoms, and Alternative was last modified:. How Do I Know If Someone Is On Codeine?. 10 Tips to Help Family Members of Those Struggling With Addiction Cope. Seeking addiction treatment can feel overwhelming. We know the struggle, which is why we're uniquely qualified to help. Don't wait another day. Help is a phone call away. How Do I Know If Someone Is On Codeine?. Having a codeine allergy is a problem some people face, which makes them unable to take this prescription opioid for pain or to treat a cough. The following provides an overview of what codeine is, and also what to know about a codeine allergy reaction, symptoms, and alternative options that may be available. Codeine is a prescription opioid, that as was touched one above, is given to patients to treat pain as well as a cough. It's considered one of the milder narcotic pain relievers, but it's not without risk. When someone takes codeine, and it reaches their brain, it's converted to morphine. It then attaches to opioid receptors, and that's how it relieves sensations of pain and suppresses the cough reflex in the brain. Codeine also slows the activity of the central nervous system, which is why it's important for patients to take it exactly as prescribed. Otherwise, an overdose is possible. When someone takes codeine, it does increase their pain tolerance, but they still feel the pain, which is why it's often combined with other pain relievers like acetaminophen. This makes it more effective as a pain reliever. Codeine also has sedative effects, so it can cause drowsiness. While less so than other opioid narcotics, codeine can be habit-forming, and it's also possible for people to have a physical dependence on it after taking it for a longer period of time, meaning they will experience symptoms of withdrawal if they suddenly stop. True codeine allergy symptoms are much like the symptoms of a pseudoallergy and can include breathlessness, dizziness, and swelling, as well as hives. If you take codeine and this happens, you should speak with your doctor to determine if it is a real allergic reaction or just your reaction to taking a mild opioid.n. The Recovery Village at Umatilla All Rights Reserved. So, what about a codeine allergy alternative? There are two different scenarios to consider when you're looking for a codeine allergy alternative. The first is what would happen if you have a pseudoallergic reaction to codeine. In this case, a doctor would most likely prescribe you a stronger opioid, because stronger opioids tend to have less noticeable histamine reactions. If you are truly allergic to codeine, you will have to be given a pain reliever from a different class of medications, because you are likely allergic to all opioid medicines. To sum up, is a codeine allergy possible? It is possible to be allergic to codeine, but it's rare. More often than not, the symptoms people experience that they think are related to a codeine allergy are just symptoms of the drug that are normal and are caused by their
body's histamine response. Some of the symptoms of codeine that could be related to an allergy or a normal response include feeling dizzy, having hives or experiencing itchiness. Regardless of whether you think these symptoms are related to a codeine allergy or not, you should contact your physician if you experience them after taking codeine. If you are truly allergic to codeine, your doctor will have to prescribe you a drug from a different class outside of opioids. 6 Steps to Take to Treat an Overdose October 11, 2018. Codeine Allergy Reaction, Symptoms, and Alternative How Would You Rate This Page?. Patients should be aware of the fact that a true codeine allergy reaction is pretty rare, although possible. In most cases, doctors describe what's thought of as a codeine allergy reaction as being a pseudoallergy instead. For example, if someone takes codeine and they experience itching, sweating, or flushing, it could be a pseudoallergy. This happens because when you take opioids, it can trigger a histamine response, which is what happens when you have an allergic reaction as well. Codeine is one of the opioids most commonly associated with pseudoallergies. The reason people tend to believe they're experiencing a codeine allergy reaction with this opioid more than others is because it's one of the less potent ones, so it is more likely to trigger a histamine release. There have been even rarer hypersensitivity reactions to codeine, including generalized maculopapular eruptions, bullous eruptions, fixed drug eruptions, drug-induced hypersensitivity syndrome, or even toxic epidermal necrolysis. 2. Eun-Mi Yang Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. Find articles by Eun-Mi Yang. 7. Nasser SM, Ewan PW. Opiate-sensitivity: clinical characteristics and the role of skin prick testing. CASE REPORT A 30-year-old woman experienced dyspnea, urticaria, chest discomfort, and sweating within 10 minutes after taking codeine orally to treat a chronic cough. She had suffered from bronchial asthma since 2010, and her asthma was frequently exacerbated following multiple attacks of upper respiratory infection. Since her severe cough did not improve after the viral infection, codeine phosphate at a dose of 10 mg a day was prescribed to suppress her symptoms for 1 week. She did not experience any adverse drug reactions during the first week of codeine treatment; however, after 1 week, approximately 10 minutes after taking the codeine, she began to develop dyspnea, urticaria, sweating, and chest discomfort. In response to these symptoms, she stopped taking the medication. The patient had perennial rhinitis and a food allergy to shellfish, which presented as hives; however, she had no previous history of any drug allergies. She was referred to our clinic for the evaluation of her codeine allergy and the uncontrolled asthma. On the first visit, eosinophilia was not detected in peripheral blood, sputum, or nasal smears. Serum total and specific IgE levels to shrimp and crab were within the normal ranges. A skin prick test (SPT) to all of the common inhalant allergens (Bencard, Bradford, UK) showed negative responses. A forced expiratory volume at 1 second (FEV 1 ), as measured by spirometry, was 62.5% predictive. After stabilizing her asthma, we planned to perform in vivo and in vitro tests to confirm whether her systemic reactions were caused by codeine and to evaluate the mechanism of the codeine-induced anaphylaxis. A SPT, a basophil histamine release test, and an open-label oral challenge test (OPT) were performed with codeine phosphate after obtaining informed consent. Furthermore, CYP2D6 genetic polymorphisms, which are often responsible for differences in responses to codeine between individuals, were evaluated. The SPT was performed with codeine (0.1-10 mg/mL) and morphine (0.1-10 mg/mL) extracts. Histam. INTRODUCTION Codeine is a methylated morphine derivative that is found naturally in poppy seeds. 1. Hye-Soo Yoo Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. Find articles by Hye-Soo Yoo. 20. Lee SY, Sohn KM, Ryu JY, Yoon YR, Shin JG, Kim JW. Sequence-based CYP2D6 genotyping in the Korean population. Comparison of histamine concentrations released from basophils after serial additions of codeine phosphate in the patient and the 2
healthy normal controls (NC1 and NC2). 13. Iriarte Sotés P, López Abad R, Gracia Bara MT, Castro Murga M, Sesma Sánchez P. Codeine-induced generalized dermatitis and tolerance to other opioids. 8. Arndt KA, Jick H. Rates of cutaneous reactions to drugs. A report from the Boston Collaborative Drug Surveillance Program. Mi-Ae Kim Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. Find articles by Mi-Ae Kim. 15. Harle DG, Baldo BA, Coroneos NJ, Fisher MM. Anaphylaxis following administration of papaveretum. Case report: implication of IgE antibodies that react with morphine and codeine, and identification of an allergenic determinant. Codeine is widely prescribed in clinical settings for the relief of pain and non-productive coughs. Common adverse drug reactions to codeine include constipation, euphoria, nausea, and drowsiness. However, there have been few reports of serious adverse reactions after codeine ingestion in adults. Here, we present a case of severe anaphylaxis after oral ingestion of a therapeutic dose of codeine. A 30-year-old Korean woman complained of the sudden onset of dyspnea, urticaria, chest tightness, and dizziness 10 minutes after taking a 10-mg dose of codeine to treat a chronic cough following a viral infection. She had previously experienced episodes of asthma exacerbation following upper respiratory infections, and had nonatopic rhinitis and a food allergy to seafood. A skin prick test showed a positive response to 1-10 mg/mL of codeine extract, with a mean wheal size of 3.5 mm, while negative results were obtained in 3 healthy adult controls. A basophil histamine release test showed a notable dose-dependent increase in histamine following serial incubations with codeine phosphate, while there were minimal changes in the healthy controls. Following a CYP2D6 genotype analysis, the patient was found to have the CYP2D6*1/*10 allele, indicating she was an intermediate metabolizer. An open label oral challenge test was positive. To the best of our knowledge, this is the first report of a patient presenting with severe anaphylaxis after the ingestion of a therapeutic dose of codeine, which may be mediated by the direct release of histamine by basophils following exposure to codeine. 4. Schoenfeld MR. Acute allergic reactions to morphine, codeine, meperidine hydrochloride, and opium alkaloids. A Case of Codeine Induced Anaphylaxis via Oral Route. 14. Gómez E, Torres MJ, Mayorga C, Blanca M. Immunologic evaluation of drug allergy. xref 65 37 0000000016 00000 n 0000001312 00000 n 0000001428 00000 n 0000001553 00000 n 0000002047 00000 n 0000002548 00000 n 0000003321 00000 n 0000003890 00000 n 0000003925 00000 n 0000003960 00000 n 0000004143 00000 n 0000004918 00000 n 0000005449 00000 n 0000005831 00000 n 0000006483 00000 n 0000007130 00000 n 0000007616 00000 n 0000008129 00000 n 0000008668 00000 n 0000009222 00000 n 0000399055 00000 n 0000401704 00000 n 0000433186 00000 n 0000433442 00000 n 0000452975 00000 n 0000453242 00000 n 0000458806 00000 n 0000459076 00000 n 0000459762 00000 n 0000459848 00000 n 0000465039 00000 n 0000465309 00000 n 0000465954 00000 n 0000466040 00000 n 0000468211 00000 n 0000468322 00000 n 0000001036 00000 n trailer. YooSeob Shin Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. Find articles by Yoo-Seob Shin. Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. In this study, we confirmed anaphylaxis by OPT. To clarify the pathogenic mechanism, we performed SPT and found positive reactions to codeine extracts. 14. Articles from Allergy, Asthma & Immunology Research are provided here courtesy of Korean Academy of Asthma, Allergy and Clinical Immunology and Korean Academy of Pediatric Allergy and Respiratory Disease. See letter " Basophil Activation Tests: A Diagnostic Break-Through in Opiate Allergy " in volume 7 on page 416. 5. Hur GY, Sheen SS, Kang YM, Koh DH, Park HJ, Ye YM, Yim HE, Kim KS, Park HS. Histamine release and inflammatory cell infiltration in airway Mucosa in methylene diphenyl diisocyanate (MDI)-induced occupational asthma. 12. Enomoto M, Ochi M, Teramae K, Kamo R, Taguchi S, Yamane T. Codeine phosphate-induced hypersensitivity syndrome. tylenol-codeine
(acetaminophen and codeine) drug - patient side effects and images. Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. Heart Disease Heart Attack vs. Cardiac Arrest vs. Heart Failure. The most common diseases caused by allergy mechanisms are those of hay fever (allergic rhinitis), asthma, eczema (allergic dermatitis), contact dermatitis, food allergy and urticaria (hives). Allergy really has different names depending upon where in your body the reaction is occurring. If an allergic reaction occurs in your nose, eyes and sinuses physicians will call it allergic rhinitis. If the allergic explosion is occurring in the lungs, we call it asthma. All of these allergic diseases are inflammatory in nature. That is to say, there is inflammation characteristic of allergy immune mechanisms occurring in those parts of your body when we give the condition the above scientific names. An overdose can damage your liver or cause death. Health & Household > Health Care > Medications & Treatments > Cough & Cold > Coughing & Sore Throats > Cough Syrups. I am allergic to codeine and morphine drugs. What can I take for pain? Kaismama is correct. I am allergic to codeine but I can take oxycodone just fine. Oxycodone is a semisynthetic alkaloid derived from thebaine where codeine is a natural alkaloid of morphine from the opium poppy. There is a good chance you can take oxycodone in spite of the codeine allergy unless you are allergic to all opioids. Oxycodone and codeine are different drugs. Is your codeine allergy a true allergy-either rash or difficulty breathing, swelling of the face or airway? Or is it an intolerance like nausea, dizziness, vomiting? Most people who think they have an allergy to codeine actually just have an intolerance to it. Dr. Brown joins us in March 2016 after 25 years of distinguished service in the US Army medical corps. She once served as chief of Allergy and Immunology department at the Madigan Army Medical Center. If I am allergic to CODEINE, but perscribed oxycodone/ percocet am I able to take this medicine?. Do not breast-feed while taking acetaminophen and codeine. which is "Oxycodone and Acetomenophin" as you know. Is Oxycodone the same as Codeine? Or Is it different and safe to use? When traveling where medical supplies are limited it is best to carry your own non-latex gloves and supplies. If you use this medicine while you are pregnant, your baby could become dependent on the drug. What should I discuss with my healthcare provider before taking acetaminophen and codeine?. Hello ladylovespink. Welcome to the site. They are different and yes, safe and effective to being taken. I hope you become/get to feeling pain ASAP. Regards pledge. What does an asthma attack feel like and what happens during an attack?. "I have bad anxiety and sleep problems I eat one of these. " - By. Acetaminophen and codeine may also be used for other purposes not listed in this medication guide. Hyland's Defend Cough Syrup, Natural Non-Drowsy Relief of Dry, Tickling, and Moist Coughs, 4 Ounces. Hundreds or even thousands of ordinary substances can trigger allergic reactions. These are called "allergens." Among the most common are plant pollens, molds, household dust (dust mites), animal dander, industrial chemicals, foods, medicines and insect stings. An allergic reaction may occur anywhere in the body, but usually appears in the skin, eyes, lining of the stomach, nose, sinuses, throat and lungs— places where special immune system cells are stationed to fight off invaders that are inhaled, swallowed or come in contact with the skin. Ask to have the first appointment of the day to reduce your risks. Latex particles can float around in the air. Mucinex 12 Hour Chest Congestion Expectorant, Tablets, 100ct, 600 mg Guaifenesin with Extended Relief. hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Our physicians, Dr. Sukanya Kanthawatana, MD, PhD. and Dr. Linda Brown, MD, are board certified allergists. Dr. Kanthawatana has been treating allergic and asthmatic patients in the Pacific Northwest for over 16 years. has gone through the roof. For denizens of today's toxic White House, Rest in
Peace, and we depend on your help!! If you see a comment by another Kossack that deserves wider recognition, The United Nations says it is suffering the world's worst humanitarian crisis. At issue was the secondtrimester procedure known as "dilation and evacuation" that is used in about 8 or 9 percent of abortions. to inhibit the feathering of one�s own nest, sometimes the company openly highlighted that it could get the financial benefits, President Donald Trump is still fuming over the Russia investigation and has Deputy Attorney General Rod Rosenstein in his crosshairs. it seems, it� �declares that the Migratory Bird Treaty Act applies only to purposeful actions that kill migratory birds, But his budget does the exact opposite of what Trump pledged to the American people. or nutraceuticals, they have rendered a judgment on that system. Of course Deerfield can�t stop someone from bringing a banned gun in secretly�just as so many of the guns in Chicago�are brought in from states like Indiana�that have weaker gun laws�but every strengthened gun law is a step in the right direction. singer and songwriter redistricting may give Cartwright a tougher opponent. the portion of Flint�s third-graders who tested as proficient in reading at grade level fell from 41.8 percent to 10.7 percent. In 2015, With no new media planned to advance the plot at present, The lesson was not lost on anyone. Wrap-up and Tidbits never gets far above the horizon,�where I live, his ability to extract it, when it wasn�t true.� Likewise, Will they be priced to align with the gender pay gap? Trump will adopt Fox's rhetoric and disgorge it on Twitter and to friendly reporters. No one answers the phone, they�ll celebrate for a week or two and our brainless media will crow about �A Big Win for Trump�, Let us fight. who else question. on May 15, It is beautiful and benevolent..
pia mellody boundaries worksheets How Long Does Codeine Stay In Your System. Seeking addiction treatment can feel overwhelming. We know the struggle, which is why we're uniquely qualified to help. Codeine is a prescription opioid, that as was touched one above, is given to patients to treat pain as well as a cough. It's considered one of the milder narcotic pain relievers, but it's not without risk. When someone takes codeine, and it reaches their brain, it's converted to morphine. It then attaches to opioid receptors, and that's how it relieves sensations of pain and
snorting oxycontin side effects See letter " Basophil Activation Tests: A Diagnostic BreakThrough in Opiate Allergy " in volume 7 on page 416. Allergy Asthma Immunol Res. 2014 Jan; 6(1): 95–97. Correspondence to: Hae-Sim Park, MD, PhD, Department of Allergy and Clinical Immunology, Ajou University School of Medicine, 206 Worldcup-ro, Yeongtong-gu, Suwon 443-721, Korea. Tel: +82-31-219-5196; Fax: +82-31-219-5154; This study is supported by the National Research Foundation (NRF), a grant from the Korean government (MEST 213003341). 1. Armstrong SC, Cozza KL.
midfoot djd icd 10 The most common causes of fatal allergic reactions include severe reactions to foods such as shellfish, peanuts and cod, or to stinging insects such as yellow jackets and imported fire ants. Be sure your doctor knows if you also use:. What may I use for post-surgical pain if I am allergic to codeine?. I am allergic to Codeine yet my doctors gave me a prescription for Percocet for some surgical pain?. You should not use this medicine if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications. Do not give this medicine to anyone
suppresses the cough reflex in the brain. Codeine also slows the activity of the central nervous system, which is why it's important for patients to take it exactly as prescribed. Otherwise, an overdose is possible. When someone takes codeine, it does increase their pain tolerance, but they still feel the pain, which is why it's often combined with other pain relievers like acetaminophen. This makes it more effective as a pain reliever. Codeine also has sedative effects, so it can cause drowsiness. While less so than other opioid narcotics, codeine can be habit-forming, and it's also possible for people to have a physical dependence on it after taking it for a longer period of time, meaning they will experience symptoms of withdrawal if they suddenly stop. How Do I Know If Someone Is On Codeine?. Don't wait another day. Help is a phone call away. Patients should be aware of the fact that a true codeine allergy reaction is pretty rare, although possible. In most cases, doctors describe what's thought of as a codeine allergy reaction as being a pseudoallergy instead. For example, if someone takes codeine and they experience itching, sweating, or flushing, it could be a pseudoallergy. This
Pharmacokinetic drug interactions of morphine, codeine, and their derivatives: theory and clinical reality, Part II. 2014 The Korean Academy of Asthma, Allergy and Clinical Immunology - The Korean Academy of Pediatric Allergy and Respiratory Disease. All Databases Assembly Biocollections BioProject BioSample BioSystems Books ClinVar Clone Conserved Domains dbGaP dbVar EST Gene Genome GEO DataSets GEO Profiles GSS GTR HomoloGene Identical Protein Groups MedGen MeSH NCBI Web Site NLM Catalog Nucleotide OMIM PMC PopSet Probe Protein Protein Clusters PubChem BioAssay PubChem Compound PubChem Substance PubMed PubMed Health SNP Sparcle SRA Structure Taxonomy ToolKit ToolKitAll ToolKitBookgh UniGene. DISCUSSION To the best of our knowledge, this is the first report of a patient who presented with codeine-induced anaphylaxis after taking an oral therapeutic dose. Codeine is commonly prescribed for the symptomatic relief of non-productive coughs, alongside other antitussives or expectorants. It suppresses the cough reflex by acting directly on the central medulla of the brain. In this study, the patient took codeine due to severe cough symptoms of asthma. Immediately after codeine ingestion,
younger than 18 years old. How to use Codeine Phosphate Tablet Consult your pharmacist or physician. Dermatology: 304 West Bay Dr. NW, #301, Olympia, WA 98502. What's the best method of testing for allergies. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices. Overdose If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-2221222. Canada residents can call a provincial poison control center. Notes No monograph available at this time. Missed Dose Consult your pharmacist or physician. Storage Consult your pharmacist or physician. Does Codeine Phosphate Tablet interact with other medications?. Since this medicine is used when needed, you may not be on a dosing schedule. If you are on a schedule, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose.
happens because when you take opioids, it can trigger a histamine response, which is what happens when you have an allergic reaction as well. Codeine is one of the opioids most commonly associated with pseudoallergies. The reason people tend to believe they're experiencing a codeine allergy reaction with this opioid more than others is because it's one of the less potent ones, so it is more likely to trigger a histamine release. True codeine allergy symptoms are much like the symptoms of a pseudoallergy and can include breathlessness, dizziness, and swelling, as well as hives. If you take codeine and this happens, you should speak with your doctor to determine if it is a real allergic reaction or just your reaction to taking a mild opioid.n. Seeking addiction treatment can feel overwhelming. We know the struggle, which is why we're uniquely qualified to help. Having a codeine allergy is a problem some people face, which makes them unable to take this prescription opioid for pain or to treat a cough. The following provides an overview of what codeine is, and also what to know about a codeine allergy reaction, symptoms, and alternative options that may be available. 10 Tips to Help Family
she developed anaphylaxis. Previous studies have suggested that cutaneous allergic reactions to codeine can be induced by the nonimmunological induction of histamine release. 3. Young-Min Ye Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. Find articles by Young-Min Ye. 6. BenShoshan M, Clarke AE. Anaphylaxis: past, present and future. 9. Rodríguez A, Barranco R, Latasa M, de Urbina JJ, Estrada JL. Generalized dermatitis due to codeine. Crosssensitization among opium alkaloids. SunHyuk Hwang Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. Find articles by Sun-Hyuk Hwang. Comparison of histamine concentrations released from basophils after serial additions of codeine phosphate in the patient and the 2 healthy normal controls (NC1 and NC2). CASE REPORT A 30-year-old woman experienced dyspnea, urticaria, chest discomfort, and sweating within 10 minutes after taking codeine orally to treat a chronic cough. She had suffered from bronchial asthma since 2010, and her asthma was frequently exacerbated following multiple attacks of upper respiratory infection. Since her severe cough did not improve after the viral infection, codeine phosphate at a dose of
Members of Those Struggling With Addiction Cope. How Do I Know If Someone Is On Codeine?. Codeine Allergy Reaction, Symptoms, and Alternative was last modified:. 6 Steps to Take to Treat an Overdose October 11, 2018. The Recovery Village at Umatilla All Rights Reserved.
10 mg a day was prescribed to suppress her symptoms for 1 week. She did not experience any adverse drug reactions during the first week of codeine treatment; however, after 1 week, approximately 10 minutes after taking the codeine, she began to develop dyspnea, urticaria, sweating, and chest discomfort. In response to these symptoms, she stopped taking the medication. The patient had perennial rhinitis and a food allergy to shellfish, which presented as hives; however, she had no previous history of any drug allergies. She was referred to our clinic for the evaluation of her codeine allergy and the uncontrolled asthma. On the first visit, eosinophilia was not detected in peripheral blood, sputum, or nasal smears. Serum total and specific IgE levels to shrimp and crab were within the normal ranges. A skin prick test (SPT) to all of the common inhalant allergens (Bencard, Bradford, UK) showed negative responses. A forced expiratory volume at 1 second (FEV 1 ), as measured by spirometry, was 62.5% predictive. After stabilizing her asthma, we planned to perform in vivo and in vitro tests to confirm whether her systemic reactions were caused by codeine and to evaluate the mechanism of the codeine-induced anaphylaxis. A SPT, a basophil histamine release test, and an
open-label oral challenge test (OPT) were performed with codeine phosphate after obtaining informed consent. Furthermore, CYP2D6 genetic polymorphisms, which are often responsible for differences in responses to codeine between individuals, were evaluated. The SPT was performed with codeine (0.1-10 mg/mL) and morphine (0.1-10 mg/mL) extracts. Histam.
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All contents copyright (C) 1998. Allergy to codeine. All rights reserved. Created: 06/30/97 Revised: 09/09/02
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