JOURNAL TRANSCRIPT
Poster Session A Sunday, September 25, 5:00 p.m.-7:30 p.m. Posters A001-A075: Americas Hall I, New York Hilton Midtown Posters A076-A148: Americas Hall II, New York Hilton Midtown
ANTIGENS AND VACCINES 1
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A001 Tumor-specific mutant antigens in cancer immunotherapy. Matthew M. Gubin , Jeffrey P. Ward , Takuro 1 1 1 2 2 2 Noguchi , Xiuli Zhang , Cora Arthur , Willem-Jan Krebber , Gwenn E. Mulder , Cornelis J.M. Melief , William E. 1 1 1 1 1 Gillanders , Maxim Artyomov , Elaine R. Mardis , Robert D. Schreiber . Washington University School of Medicine, 2 Saint Louis, MO; ISA Therapeutics B.V., Leiden, Netherlands. A002 T cell responses to peptide-epitopes of choice can be boosted by immune complexes of circulating anti1 2 2 3 3 3 tetanus toxoid antibodies. E. Fletcher , W. van Maren , R. Cordfunke , J. Dinkelaar , R. Castelli , J.D.C. Codee , G. 3 2 2 2 1 1 van der Marel , C.J.M. Melief , J.W. Drijfhout , F. Ossendorp , S.M. Mangsbo . Department of Immunology, 2 Genetics and Pathology, Uppsala University, Uppsala, Sweden; Department of Immunohematology & Blood 3 Transfusion, Leiden University Medical Center, Leiden, Netherlands; Department of Bio-organic Synthesis, Leiden University, Leiden, Netherlands. This abstract is being presented as a short talk in Session 1 of the scientific program. 1
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A003 A personalized neoantigen vaccine in patients with high risk melanoma. Patrick A. Ott , Zhuting Hu , Derin 1 1 1 2 3 1 1 B. Keskin , Sachet A. Shukla , Jing Sun , Ed Fritsch , Nir Hacohen , Catherine J. Wu . Dana Farber Cancer Institute, 2 3 Boston, MA; Neon Therapeutics, Cambridge, MA; Broad Institute of MIT and Harvard, Cambridge, MA. This abstract is being presented as a short talk in Session 1 of the scientific program. A004 Systemic RNA vaccines: Connecting effective cancer immunotherapy with antiviral defense 1 1 2 1 3 mechaniSms. Lena M. Kranz , Mustafa Diken , Heinrich Haas , Sebastian Kreiter , Carmen Loquai , Kerstin C. 2 2 2 1 2 4 4 Reuter , Martin Meng , Daniel Fritz , Fulvia Vascotto , Hossam Hefesha , Christian Grunwitz , Mathias Vormehr , 2 1 2 2 5 1 Yves Hüsemann , Abderraouf Selmi , Andreas N. Kuhn , Janina Buck , Evelyna Derhovanessian , Richard Rae , 1 2 2 2 6 7 Sebastian Attig , Jan Diekmann , Robert A. Jabulowsky , Sandra Heesch , Jessica Hassel , Peter Langguth , Stephan 3 1 8 1 1 Grabbe , Christoph Huber , Özlem Türeci , Ugur Sahin . TRON-Translational Oncology Mainz, Mainz, Germany; 2 3 BioNTech RNA Pharmaceuticals, Mainz, Germany; University Medical Center of the Johannes Gutenberg 4 University Mainz, Mainz, Germany; Research Center for Immunotherapy (FZI), University Medical Center at the 5 6 Johannes Gutenberg University Mainz, Mainz, Germany; BioNTech, Mainz, Germany; Heidelberg University 7 8 Hospital, Heidelberg, Germany; Johannes Gutenberg University Mainz, Mainz, Germany; Cluster for Individualized Immune Intervention, Mainz, Germany. A005 Tumor- and host-intrinsic RIG-I signaling promote anticancer immunity by CTLA-4 blockade. Simon 1 1 1 1 2 1 Heidegger , Alexander Wintges , Diana Kreppel , Sarah Bek , Michael Bscheider , Martina Schmickl , Marcel R.M. 3 1 1 1 1 van den Brink , Christian Peschel , Tobias Haas , Hendrik Poeck . Klinikum rechts der Isar, TU Munich, Munich, 2 3 Germany; Stanford University School of Medicine, Stanford, CA; Memorial Sloan Kettering Cancer Center, New York City, NY.
Poster Session A Sunday, September 25, 5:00 p.m.-7:30 p.m. Posters A001-A075: Americas Hall I, New York Hilton Midtown Posters A076-A148: Americas Hall II, New York Hilton Midtown A006 Frameshift peptide neoantigens as vaccine targets in microsatellite-unstable cancers. Magnus von Knebel 1 1 1 2 2 Doeberitz , Matthias Kloor , Miriam Reuschenbach , Claudia Pauligk , Mohammad-Reza Rafiyan , Salah-Eddin Al 2 2 3 2 1 Batran , Julia Karbach , Mirjam Tariverdian , Elke Jaeger . University of Heidelberg, Heidelberg, Germany; 2 3 Krankenhaus Nordwest, UCT University Cancer Center, Frankfurt, Germany; Department of Surgery, University Hospital Heidelberg, Heidelberg, Germany. A007 Intratumoral delivery of inactivated vaccinia virus is more efficacious than live oncolytic vaccinia virus in murine bilateral tumor implantation models. Weiyi Wang, Peihong Dai, Ning Yang, Stewart Shuman, Taha Merghoub, Jedd D. Wolchok, Liang Deng. Memorial Sloan Kettering Cancer Center, New York, NY. A008 Photochemical internalization: Light-induced enhancement of MHC Class I antigen presentation, giving 1 2 2 strong enhancement of cytotoxic T-cell responses to vaccination. Tone Otterhaug , Markus Haug , Gaute Brede , 3 3 3 3 4 2 Monika Håkerud , Anne Grete Nedberg , Victoria Edwards , Pål Kristian Selbo , Pål Johansen , Øyvind Halaas , 1 1 2 Anders Høgset . PCI Biotech AS, Oslo, Norway; The Norwegian University of Science and Technology, Trondheim, 3 4 Norway; Oslo University Hospital – The Norwegian Radium Hospital, Oslo, Norway; Department of Dermatology, University Hospital Zürich, Oslo, Switzerland. 1
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A009 Benchmarking the foreign antigen space of human malignancies. Maarten Slagter , Lorenzo Fanchi , Marit 1 1 1 1 1 1 2 M. van Buuren , Jorg J A Calis , Philip Schouten , Sabine Linn , Marlous Hoogstraat , Arno Velds , Hendrik Veelken , 1 3 3 3 1 Ron M. Kerkhoven , Andrew Menzies , Ludmil B. Alexandrov , Michael Stratton , Lodewyk Wessels , Ton N. 1 1 2 Schumacher . Netherlands Cancer Institute, Amsterdam, Netherlands; Leiden University Medical Center, Leiden, 3 Netherlands; Wellcome Trust Sanger Institute, Hinxton, United Kingdom. A010 A novel DNA vaccine targeting fibroblast activation protein (FAP) breaks tolerance and synergizes with 1 1 1 2 anticancer immune therapy in mice. Elizabeth Duperret , Dylan Ammons , Megan C. Wise , Jian Yan , Laurent M. 2 1 1 2 Humeau , David B. Weiner . Wistar Institute, Philadelphia, PA; Inovio Pharmaceuticals, Plymouth Meeting, PA. A011 Tissue profiling reveals lifelong specialization of dendritic cell subsets in humans. Tomer Granot, Takashi Senda, Dustin Carpenter, Donna L. Farber. Columbia University, New York, NY. A012 Combining in situ vaccination with immune checkpoint blockade induces long-term regression of 1 2 2 3 1 1 lymphoma tumors. Linda Hammerich , Thomas Davis , Tibor Keler , Andres M. Salazar , Joshua D. Brody . Icahn 2 3 School of Medicine at Mount Sinai, New York, NY; Celldex Therapeutics, Needham, MA; Onovir, Inc, Washington, DC. A013 Favorable changes in tumor microenvironment following intravenous dosing with live attenuated Listeria 1 2 1 1 monocytogenes-based immunotherapy. Weiwen Deng , Takahiro Tsujikawa , Nitya Nair , Thomas Hudson , 1 1 1 1 1 1 Weiqun Liu , Chris S. Rae , Edward E. Lemmens , Anthony W. Desbien , William Hanson , Peter Lauer , Lisa M. 2 1 1 1 1 Coussens , Dirk G. Brockstedt , Thomas W. Dubensky, Jr. , Meredith L. Leong . Aduro Biotech, Berkeley, CA; 2 Oregon Health Sciences University, Portland, OR. A014 CIITA dependent MHC class II IA expression in tumor cells triggers CD4 T cell protective and long lasting antitumor immunity. Farah Bou Nasser Eddine, Greta Forlani, Giovanna Tosi, Roberto S. Accolla. University of Insubria, Varese, Italy.
Poster Session A Sunday, September 25, 5:00 p.m.-7:30 p.m. Posters A001-A075: Americas Hall I, New York Hilton Midtown Posters A076-A148: Americas Hall II, New York Hilton Midtown A015 Protein arginine deiminase enzymes which citrullinate epitopes for MHC II presentation are independent predictors of survival in colorectal cancer. R. Metheringham, M. Gijon, I. Daniels, K. Cook, P. Symonds, T. Pitt, W. Xue, V. Brentville, L. Durrant. Scancell Limited, Nottingham, United Kingdom. A016 Multipotency of a CD40L-expressing recombinant vaccinia virus. Emanuele Trella. University Hospital Basel, Basel, Switzerland. A017 Method for molecular characterization of antigens, epitopes and T cell receptors for adoptive CD4 immunotherapy. Milosevic Slavoljub, Ellinger Christian, Wehner Carina, Raffegerst Silke, Wilde Susanne, Weis Manon, Sailer Nadja, Schendel Dolores. Medigene, Planegg/Martinsried, Germany. A018 High-value T cell epitope selection for mutanome-directed cancer immunotherapy using an innovative cancer neo-epitope classification system. Lenny Moise, Guilhem Richard, Frances Terry, William Martin, Anne De Groot. EpiVax Inc, Providence, RI. A019 Chimeric antigen receptors (CARs) as a low-impact treatment of pediatric ependymomas. Laura K. 1 2 1 2 1 1 Donovan , Kevin J. Bielamowicz , Alex Manno , Nabil Ahmed , Michael D. Taylor . The Hospital for Sick Children, 2 Toronto, ON, Canada; Baylor College of Medicine, Houston, TX. A020 A novel synthetic CD40L plasmid adjuvant generates unique anti-HPV DNA vaccine induced responses 1 1 2 1 3 that impact tumor growth. Megan C. Wise , Elizabeth K. Duperret , Daniel O. Villarreal , Lumena Louis , Jian Yan , 3 3 3 1 1 Matthew P. Morrow , Laurent M. Humeau , Niranjan Y. Sardesai , David B. Weiner . Wistar Insititute, 2 3 Philadelphia, PA; University of Pennsylvania, Philadelphia, PA; Inovio Pharmaceuticals, Plymouth Meeting, PA. A021 Development of an ALK vaccine to treat ALK-rearranged non-small cell lung cancers. Rafael B. Blasco. Boston Children´s Hospital, Boston, MA. 1
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A022 Computational pipeline for a personalized genomic vaccine trial. Alexander Rubinsteyn , Isaac Hodes , 1 1 1 2 1 1 Timothy O'Donnell , Sebastien F. Mondet , John P. Finnigan , Philip Friedlander , Rachel Sabado , Nina Bhardwaj , 1 1 2 Jeffrey Hammerbacher . Icahn School of Medicine at Mount Sinai School, New York, NY; Mount Sinai Hospital, New York, NY. A023 Inducing neoantigens in disseminated tumor lesions to enhance their susceptibility to PD-1 blockade therapy. Greta Garrido Hidalgo, Agata Levay, Alexey Berezhnoy, Brett Schrand, Eli Gilboa. University of Miami, Miami, FL. A024 Predicting cancer survival with neo-epitope burden. Nicholas K. Akers, Eric Schadt, Bojan Losic. Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY. A025 Association of functionally distinct ERAP1 variants in HPV positive cancer. Emma Reeves, Emma King, Tim Elliott, Gareth Thomas, Edward James. University of Southampton, Southampton, United Kingdom.
Poster Session A Sunday, September 25, 5:00 p.m.-7:30 p.m. Posters A001-A075: Americas Hall I, New York Hilton Midtown Posters A076-A148: Americas Hall II, New York Hilton Midtown A026 Tumor-specific glycosylated CD43 is a novel and highly specific target for acute myeloid leukemia and 1 2 2 1 2 myelodysplastic syndrome. Marijn Gillissen , Martijn Kedde , Etsuko Yasuda , Greta De Jong , Sophie Levie , Arjen 2 3 2 2 1 2 Bakker , Paul Hensbergen , Julien Villaudy , Tim Beaumont , Pauline van Helden , Hergen Spits , Mette D. 1 1 2 Hazenberg . Academic Medical Center, Amsterdam, Netherlands; AIMM Therapeutics, Amsterdam, Netherlands; 3 Leiden University Medical Center, Leiden, Netherlands. A027 HLA-DP restricted responses to citrullinated proteins are pre-existing in the memory pool and can be 1 1 1 rapidly reactivated to provide good tumor therapy. Victoria Brentville , Rachael Metheringham , Ian Daniels , 1 1 1 1 1 2 1 Katherine Cook , Peter Symonds , Tracy Pitt , Wei Xue , Mohamed Gijon , Lindy Durrant . Scancell Ltd, 2 Nottingham, United Kingdom; Nottingham University, Nottingham, United Kingdom. A028 Pre-clinical development of a first-in-class fully synthetic heat shock protein-based personalized cancer vaccine. Mithun Khattar, Antoine Tanne, Benjamin Morin, Nicholas Wilson, Mohamed Uduman, Justin Zelin, Robert Stein, Mark Exley, John Castle, Daniel L. Levey. Agenus Inc., Lexington, MA. A029 A vaccine-induced, antigen-specific TH9 immune response blocks tumor cell engraftment. Aws AbdulWahid, Aaron Prodeus, Marzena Cydzik, Mays Alwash, Jean Gariepy. University of Toronto, Toronto, ON, Canada. A030 Development of acid responsive microparticles for cytotoxic T-lymphocyte based antitumor immunotherapy. Xuefei Huang, Herbert Kavunja, Shuyao Lang, Suttipun Sungsuwan, Zhaojun Yin. Michigan State University, East Lansing, MI. A031 Cancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy. Yared 1 1 2 1 1 2 Hailemichael , Tihui Fu , Amber Woods , Jason Roszik , Kimberly S. Schluns , Victor H. Engelhard , Padmanee 1 1 1 2 Sharma , Willem W. Overwijk . UT MD Anderson Cancer Center, Houston, TX; University of Virginia School of Medicine, Charlottesville, VA. A032 Using oncolytic polio expressing tumor as a cancer vaccine. M Mubeen Mosaheb, Elena Dobrikova, Michael C. Brown, Christopher Pirozzi, Vidyalakshmi Chandramohan, Eda Holl, Smita Nair, Matthias Gromeier. Duke University, Durham, NC. A033 Mechanisms that mediate intralocus and interlocus regulation of V(D)J recombination at 1 1 1 1 2 immunoglobulin light chain loci. Zhaoqing Ba , Jiazhi Hu , Zhou Du , Sherry G. Lin , Duane R. Wesemann , 1 1 Frederick W. Alt . Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Children's 2 Hospital Boston, Department of Genetics, Harvard Medical School, Boston, MA; Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA. A034 Boosting the efficacy of PD-L1 blockade with oncolytic vaccine for improved antitumor responses in melanoma. Cristian Capasso, Siri Tähtinen, Federica Frascaro, Sara Carpi, Manlio Fusciello, Davide Cardella, Daniela Cropp, Karita Peltonen, Beatriz Martins, Madeleine Sjöberg, Sari Pesonen, Tuuli Ranki, Lukasz Kuryk, Erkko Ylösmäki, Vincenzo Cerullo. Laboratory of Immunovirotherapy, Division of Pharmaceutical Biosciences & Center for Drug Research, University of Helsinki, Helsinki, Finland. 1
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A035 Citrullinated α-enolase as a novel target for cancer immunotherapy. Katherine Cook , Ian Daniels , 1 1 1 1 1 1 Victoria Brentville , Rachael Metheringham , Wei Xue , Peter Symonds , Tracy Pitt , Mohammed Gijon , Lindy G. 2 1 2 Durrant . Scancell Ltd, Nottingham, United Kingdom; University of Nottingham, Nottingham, United Kingdom.
Poster Session A Sunday, September 25, 5:00 p.m.-7:30 p.m. Posters A001-A075: Americas Hall I, New York Hilton Midtown Posters A076-A148: Americas Hall II, New York Hilton Midtown 1
A036 Somato-germinomics antigens are immunogenic cancer stem cell antigens. Toshihiko Torigoe , Yoshihiko 1 1 1 1 1 2 Hirohashi , Tomohide Tsukahara , Takayuki Kanaseki , Munehide Nakatsugawa , Terufumi Kubo , Kochin Vitaly . 1 2 Sapporo Medical University School of Medicine, Sapporo, Japan; Nagoya University, Nagoya, Japan. A037 The Agenus Immunogenic Mutation platform (AIM™) generates synthesis-ready blueprints for the AutoSynVax™ vaccine patient-specific neo-antigen vaccine. Mohamed Uduman, Armen Karapetyan, Mithun Khattar, Antoine Tanne, Benjamin Morin, Justin Zelin, Sandra Craig, Shiwen Shiwen, Bishnu Joshi, Mark A. Findeis, Nicholas Wilson, Elise Drouin, Amy Yang, Jeffrey Raizer, John Goldberg, Jennifer Buell, Robert Stein, John Castle, Daniel L. Levey. Agenus Inc., Lexington, MA. A038 Oncolytic virotherapy combination with DC-based immunotherapy for the treatment of melanoma. Zoltan Banki, Iris Koske, Isabel Barnstorf, Christoph Tripp, Patrizia Stoitzner, Nikolaus Romani, Guido Wollmann, Janine Kimpel, Dorothee Holm-von Laer. Medical University Innsbruck, Innsbruck, Austria. A039 Accurate identification and prioritization of candidate neoantigens from cancer exome sequencing. James White, John Simmons, Sam Angiuoli, Mark Sausen, Sian Jones, Lisa Kann, Manish Shukla, Maria Sevdali, Victor Velculescu, Luis Diaz, Theresa Zhang. Personal Genome Diagnostic, Baltimore, MD. A040 The low antitumor functionality of PD1-positive gp100-specific CD8+ T cell clones isolated from 1 melanoma patients correlates with the presence of CD28 co-stimulatory molecule. Belinda Palermo , Ornella 2 1 1 1 1 1 Franzese , Cosmo Di Donna , Mariangela Panetta , Isabella Sperduti , Antonella Soriani , Maria Laura Foddai , 3 1 1 2 Angela Santoni , Paola Nisticò . Regina Elena National Cancer Institute, Rome, Italy; University of Rome Tor 3 Vergata, Rome, Italy; University of Rome La Sapienza, Rome, Italy. 1
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A041 Preclinical development of a preventive vaccine against ovarian cancer. Nathalie Scholler , Paul Stein , 1 1 1 1 2 2 Khushboo Sharma , Claire Repellin , Kalika Kamat , Travis Harrison , Robert H. Shoemarker , Shizuko Sei , Lidia 1 1 2 Sambucetti . SRI International, Menlo Park, CA; Division of Cancer Prevention, NCI, NIH, Bethesda, MD. A042 Targeting of alpha-enolase (ENO1) as a novel immunotherapeutical strategy for pancreatic cancer. Francesco Novelli, Michela Capello, Michelle Chattaragada, Sammy Ferri Borgogno, Giorgia Mandili, Moitza Principe, Emanuela Mazza, Sara Bulfamante, Roberta Curto, Daniele Giordano, Paola Cappello. University of Turin, Turin, Italy. A043 Discovery to first-in-man studies of a multi-peptide-based hepatocellular carcinoma vaccine adjuvanted ® 1 2 3 4 with CV8102 (RNAdjuvant ): HEPAVAC. Andrea Mayer-Mokler , Roberto Accolla , Yuk T. Ma , Regina Heidenreich , 5 6 6 1 1 1 Francesco Izzo , Alfred Koenigsrainer , Markus Loeffler , Christian Flohr , Phillip Mueller , Sarah Kutscher , Hans6 7 8 9 1 1 Georg Rammensee , Bruno Sangro , Sven Francque , Danila Valmori , Toni Weinschenk , Carsten Reinhardt , Ulrike 4 1 5 1 2 Gnad-Vogt , Harpreet Singh , Luigi Buonaguro . Immatics, Tuebingen, Germany; University of Insubria, Varese, 3 4 5 Italy; University of Birmingham, Birmingham, United Kingdom; CureVac AG, Tuebingen, Germany; National 6 7 Cancer Institute, Naples, Italy; University of Tuebingen, Tuebingen, Germany; University of Navarra, Pamplona, 8 9 Spain; University of Antwerpen, Antwerpen, Belgium; INSERM, Nantes, France. 1
A044 Immunological effects of a novel RNA-based adjuvant in liver cancer patients. Luisa Circelli , Annacarmen 1 1 2 1 1 Petrizzo , Maria Tagliamonte , Regina Heidenreich , Maria Lina Tornesello , Franco M. Buonaguro , Luigi 1 1 2 Buonaguro . National Cancer Institute, Naples, Italy; CureVac AG, Tuebingen, Germany.
Poster Session A Sunday, September 25, 5:00 p.m.-7:30 p.m. Posters A001-A075: Americas Hall I, New York Hilton Midtown Posters A076-A148: Americas Hall II, New York Hilton Midtown A045 Inhibition of tumor growth by combination of metronomic chemotherapy and checkpoint inhibitor with a cancer vaccine. Maria Tagliamonte, Annacarmen Petrizzo, Angela Mauriello, Antonio Luciano, Domenica Rea, Antonio Barbieri, Claudio Arra, Piera Maiolino, Maria Lina Tornesello, Gennaro Ciliberto, Franco M. Buonaguro, Luigi Buonaguro. National Cancer Institute, Naples, Italy. A046 Identification and validation of HCC-specific gene transcriptional signature for tumor antigen 1 2 1 1 discovery. Annacarmen Petrizzo , Francesca P. Caruso , Maria Tagliamonte , Maria Lina Tornesello , Michele 2 3 3 3 1 1 Ceccarelli , Valerio Costa , Marianna Aprile , Roberta Esposito , Gennaro Ciliberto , Franco M. Buonaguro , Luigi 1 1 2 3 Buonaguro . National Cancer Institute, Naples, Italy; University of Sannio, Benevento, Italy; IGB - CNR, Naples, Italy.
NEW CHECKPOINTS A048 CPI-444: A potent and selective inhibitor of A2AR induces antitumor responses alone and in combination with anti-PD-L1 in preclinical and clinical studies. Stephen Willingham, Andrew Hotson, Po Ho, Carmen Choy, Ginna Laport, Ian McCaffery, Richard Miller. Corvus Pharmaceuticals, Burlingame, CA. This abstract is being presented as a short talk in Session 2 of the scientific program. A049 HVEM (TNFRSF14) tumor suppressor in immune therapies of follicular lymphoma. Darin Salloum. Memorial Sloan Kettering Cancer Center, New York, NY. This abstract is being presented as a short talk in Session 3 of the scientific program. A050 Cdk5 disruption attenuates tumor PD-L1 expression via regulation of IFN-γ signaling components and promotes antitumor immunity. Rodney D. Dorand, Jr., Joseph Nthale, Jay T. Myers, Deborah S. Barkauskas, Stefanie Avril, Steven M. Chirieleison, Tej K. Pareek, Derek W. Abbott, Duncan S. Stearns, John J. Letterio, Alex Y. Huang, Agne Petrosiute. Case Western Reserve University, Cleveland, OH. A051 Characterization of IDO1 and TDO2 in pediatric central nervous system tumors. Kristen Lauing, Rishi Lulla, Lijie Zhai, Rintaro Hashizume, Jason Fangusaro, Derek A. Wainwright. Northwestern University Feinberg School of Medicine, Chicago, IL. A052 Characterization of immune regulatory molecules B7-H4, PD-L1, and ICOS in micro-satellite stable (MSS) 1 2 1 and micro-satellite instable (MSI) endometrial tumors. Amit Deshpande , Whitfield B. Growdon , Heather Hirsch , 1 1 1 2 2 1 1 Tong Zi , Chris Grange , Jason Reeves , Jennifer Stall , Bo Rueda , Sriram Sathyanarayanan . Jounce Therapeutics, 2 Cambridge, MA; Massachusetts General Hospital, Boston, MA. 1
A053 Targeting ICOS improves immune-mediated control of tumor growth in humanized mice. Aude Burlion , 2 1 1 2 Aurélien Corneau , Gilles Marodon . CIMI INSERM, Paris, France; UPMC, Paris, France. 1
A054 Inhibition of TGF-beta isoforms 1 and 2 enhances therapeutic tumor vaccine efficacy. Katharine Clark , 1 1 1 1 2 1 1 Faith C. Robertson , Emma De Ravin , Shingo Kato , Anja Bloom , Amer Mirza , Jay A. Berzofsky , Masaki Terabe . 1 2 NIH, Bethesda, MD; Xoma, Berkeley, CA.
Poster Session A Sunday, September 25, 5:00 p.m.-7:30 p.m. Posters A001-A075: Americas Hall I, New York Hilton Midtown Posters A076-A148: Americas Hall II, New York Hilton Midtown 1
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A055 Systematic discovery of combinationimmunotherapy targets in vivo. Adam N. Cartwright , Rong En Tay , 2 1 2 Kai W. Wucherpfennig . Dana Farber Cancer Institute, Boston, MA; Dana Farber Cancer Institute, Boston, MA.
OTHER TOPICS A056 Identifying the epigenetic code of tumor-specific CD8 T cell dysfunction and therapeutic reprogramming. Mary Philip, Lauren Fairchild, Liping Sun, Agnes Viale, Steven Camara, Ellen Horste, Taha Merghoub, Jedd D. Wolchok, Christina S. Leslie, Andrea Schietinger. Memorial Sloan Kettering Cancer Center, New York, NY. This abstract is being presented as a short talk in Session 5 of the scientific program. 1
A057 CX3CR1 distinguishes three distinct migratory memory CD8 T cell subsets. Carmen Gerlach , E. Ashley 1 1 1 1 1 1 Moseman , Scott M. Loughhead , David Alvarez , Anthonie J. Zwijnenburg , Lisette Waanders , Rohit Garg , Juan C. 2 1 1 2 de la Torre , Ulrich H. von Andrian . Harvard Medical School, Boston, MA; The Scripps Research Institute, La Jolla, CA. A058 Selective targeting of T regulatory cells by a TCR-mimic monoclonal antibody specific for foxp3-derived 1 1 1 1 1 1 epitopes. Tao Dao , Casey Jarvis , Andrew C. Scott , Tatyana Korontsvit , Victoria Zakhaleva , Dmitry Pankov , 1 1 2 2 1 1 Manuel Direito de Morais Guerrerio , Melissa Mathias , Neal Cheng , Cheng Liu , David A. Scheinberg . Memorial 2 Sloan Kettering Cancer Center, New York, NY; Eureka Therapeutics, Inc, Emeryville, CA. A059 Combinatorial proteomic analysis of the receptor programmed cell death (PD)-1 uncovers new checkpoint modulators. Michael Peled, Adam Mor. NYU School of Medicine, New York, NY.
A060 The effects of tumor-associated calreticulin mutants on antigen presentation. Najla Arshad, Peter Cresswell. Yale University School of Medicine, New Haven, CT. A061 Acute myeloid leukemia patients cured after allogeneic hematopoietic stem cell transplantation generate 1 2 1 tumor-specific cytotoxic antibodies that kill AML blasts. Marijn Gillissen , Martijn Kedde , Greta De Jong , Etsuko 2 2 2 2 2 2 2 Yasuda , Sophie Levie , Arjen Bakker , Yvonne Claassen , Koen Wagner , Julien Villaudy , Martino Bohne , Dave 1 3 2 2 2 1 1 Speijer , Paul Hensbergen , Pauline van Helden , Tim Beaumont , Hergen Spits , Mette D. Hazenberg . Academic 2 3 Medical Center, Amsterdam, Netherlands; AIMM Therapeutics, Amsterdam, Netherlands; Leiden University Medical Center, Leiden, Netherlands. 1
A062 The effects of cellular context on miR-155 mediated regulation of gene expression. Jing-Ping Hsin , 2 2 1 1 Yuheng Lu , Christina S. Leslie , Alexander Y. Rudensky . Immunology Program, Sloan Kettering Institute, New 2 York, NY; Computational Biology Program, Sloan Kettering Institute, New York, NY. A063 Dissecting adipose tissue Treg differentiation and function in metabolism and obesity-associated cancer using TCR transgenic mice. Chaoran Li, Christophe Benoist, Diane Mathis. Harvard Medical School, Boston, MA.
Poster Session A Sunday, September 25, 5:00 p.m.-7:30 p.m. Posters A001-A075: Americas Hall I, New York Hilton Midtown Posters A076-A148: Americas Hall II, New York Hilton Midtown A064 IDO1 expression stratifies glioblastoma patient survival and correlates with dominantly 1 1 1 1 1 immunosuppressive pathways. Lijie Zhai , Matthew Genet , Erik Ladomersky , Kristen Lauing , Meijing Wu , David 2 3 3 4 5 6 7 Binder , Leo Kim , Jeremy Rich , Craig Horbinski , C. David James , Jeffrey A. Sosman , Orin Bloch , Derek A. 8 1 2 Wainwright . Department of Neurological Surgery, Northwestern University, Chicago, IL; Department of 3 Pathology, University of Chicago, Chicago, IL; Department of Stem Cell Biology and Regenerative Medicine, Lerner 4 Research Institute, Cleveland Clinic, Cleveland, OH; Department of Neurological Surgery, Department of 5 Pathology, Northwestern University, Chicago, IL; Department of Neurological Surgery, Department of Biochemistry and Molecular Genetics, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 6 Chicago, IL; Division of Hematology and Oncology, Robert H. Lurie Comprehensive Cancer Center of Northwestern 7 University, Chicago, IL; Department of Neurological Surgery, Robert H. Lurie Comprehensive Cancer Center, 8 Northwestern University, Chicago, IL; Department of Neurological Surgery, Department of MicrobiologyImmunology, Division of Hematology and Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL. A065 Oscillatory genes in lymphocyte retention and egress. Hsin Chen, Timothy Schmidt, Ying Xu, Erick Lu, Jason G. Cyster. UCSF, San Francisco, CA. A066 NF-kB restricts inflammasome activation via elimination of damaged mitochondria. Zhenyu Zhong, Michael Karin. University of California, San Diego, La Jolla, CA. A067 PD-1 blockade enhances OX40 expression on regulatory T-cells and decreases suppressive function 1 2 1 through induction of phospho-STAT3 signaling. David M. Woods , Rupal Ramakrishnan , Andressa L. Sodré , 2 1 1 2 Anders Berglund , Jeffrey Weber . NYU Langone Medical Center, New York, NY; Moffitt Cancer Center, Tampa, FL. 1
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A068 Determinants of efficacy in cancer immunovirotherapy. Rūta Veinalde , Christian Grossardt , Marie2 1 3 3 1 1 Claude Bourgeois-Daigneault , Christof von Kalle , Dirk Jaeger , Guy Ungerechts , Christine E. Engeland . National Center for Tumor Diseases Heidelberg, Department of Translational Oncology, German Cancer Research Center, 2 Heidelberg, Germany; Ottawa Hospital Research Institute, Centre for Innovative Cancer Research, Ottawa, ON, 3 Canada; National Center for Tumor Diseases Heidelberg, Department of Medical Oncology, Heidelberg, Germany. A069 Quantification of lymph node transit times reveals differences in the trafficking behavior of regulatory + versus conventional CD4 T cells. Alexander Tong. Case Western Reserve University, Cleveland, OH. 1
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A070 The role of the centrosome in cytotoxic T cell function . Fella Tamzalit , Ariella Kepecs , Hisham Bazzi , 1 1 1 2 Kathryn Anderson , Morgan Huse . Memorial Sloan Kettering Cancer Center, New York, NY; Cluster of Excellence - Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany. A071 Identification and characterization of long intergenic non-coding RNAs (lincRNAs) governing T cell 1 1 2 3 4 development and function. Will Bailis , Christian Harman , Jorge Henao-Mejia , Adam Williams , Loyall Goff , John 5 1 1 2 3 Rinn , Richard Flavell . Yale University, New Haven, CT; University of Pennsylvania, Philadelphia, PA; The Jackson 4 5 Laboratory, Farmington, CT; Johns Hopkins University, Baltimore, MD; Harvard University, Cambridge, MA. A072 Glucose metabolism and O-linked GlcNAcylation in the tissue repair function of Treg cells. Wei Hu, Nicholas Arpaia, Jesse A. Green, Ronald C. Hendrickson, Alexander Y. Rudensky. Memorial Sloan Kettering Cancer Center, New York, NY.
Poster Session A Sunday, September 25, 5:00 p.m.-7:30 p.m. Posters A001-A075: Americas Hall I, New York Hilton Midtown Posters A076-A148: Americas Hall II, New York Hilton Midtown 1
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A073 Epigenetic regulation of the Cd4 locus. Priya Issuree , Kenny Day , Dan R. Littman . NYU School of 2 Medicine, New York, NY; HudsonAlpha Institute for Biotechnology, Alabama, AL. A074 A Zap70-dependent negative feedback loop governs Lck activation by CD45. Adam H. Courtney, Theresa A. Kadlecek, Byron Au-Yeung, Arthur Weiss. University of California, San Francisco, San Francisco, CA. A075 Preclinical analysis of combinatorial glioblastoma therapy with the prodrug-mediated gene therapy 1 1 vector AdV-TK and immune checkpoint inhibition in GBM therapy. Maria Carmela Speranza , Kazue Kasai , Franz 1 2 1 1 1 1 Ricklefs , Sarah R. Klein , Carmela Passaro , Hiroshi Nakashima , Johanna Kaufmann , Agnieszka Bronisz , Estuardo 3 3 2 2 2 1 Aguilar-Cordova , Brian W. Guzik , Gordon J. Freeman , David A. Reardon , Patrick Wen , E. Antonio Chiocca , Sean 1 1 2 E. Lawler . Harvard Medical School - Brigham and Women's Hospital, Boston, MA; Dana-Farber Cancer Institute, 3 Harvard Medical School, Boston, MA; Advantagene Inc., Auburndale, MA.
MICROBIOTA A076 Cutaneous microbiota drive the accumulation of IL-17A-producing T cells within the lungs. Michael G. Constantinides, Vanessa K. Ridaura, Yasmine Belkaid. National Institute of Allergy and Infectious Diseases, Bethesda, MD. A077 Identifying novel effectors of the gut microbiota that modulate cancer cell killing by CTLs using functional metagenomics. Lior Lobel, Wendy Garret. Harvard T.H. Chan School of Public Health, Boston, MA. 1
A078 Cutaneous microbiota in development of endogenous anti-melanocyte immunity. Ivan Vujkovic-Cvijin , 1 2 2 1 1 2 1 1 Jacquice Davis , Rasnik Singh , Kristina Lee , Zhiya Yu , Nicholas Restifo , Maria Wei , Yasmine Belkaid . National 2 Institutes of Health, Bethesda, MD; University of California San Francisco, San Francisco, CA. A079 Bioorthogonal chemical labeling of specific immunomodulatory surface molecules in live commensals. Jason E. Hudak, David Alvarez, Ashwin Skelly, Ulrich H. von Andrian, Dennis L. Kasper. Harvard Medical School, Boston, MA. This abstract is being presented as a short talk in Session 4 of the scientific program. +
A080 Balance of commensal bacteria specific Th17 and RORγt Treg cells in intestinal homeostasis and 1 2 1 1 3 1 inflammation. Mo Xu , Yi Yang , Maria Pokrovskii , Carolina Galan , Dan R. Littman . The Kimmel Center for 2 Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY; Department 3 of Microbiology & Immunology, Medical University of South Carolina, Charleston, SC; The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, Howard Hughes Medical Institute, New York, NY. A081 Chemical biology of microbial metabolite targets in host immunity. Yen-Chih Wang. The Rockefeller University, New York, NY.
Poster Session A Sunday, September 25, 5:00 p.m.-7:30 p.m. Posters A001-A075: Americas Hall I, New York Hilton Midtown Posters A076-A148: Americas Hall II, New York Hilton Midtown A082 Identification of commensal bacterial strains that provide resistance to L. monocytogenes infection. Simone Becattini, Sohn G. Kim, Rebecca A. Carter, Lilan Ling, Ingrid M. Leiner, Eric G. Pamer. Memorial Sloan Kettering Cancer Center, New York, NY.
TUMOR MICROENVIRONMENT A083 Molecular profiling of CD8 T cells from autochthonous melanoma identifies Maf as driver of T cell 1 2 2 1 1 exhaustion. Gregory Verdeil , Marilyn Giordano , Anne-Marie Schmitt-Verhulst , Daniel Speiser , Claire Imbratta . 1 2 UNIL, Epalinges, Switzerland; CIML, Marseille, France. A084 High OX-40 expression on the tumor immune infiltrate is a prognostic factor of better survival in non1 2 2 2 small cell lung cancer. Erminia Massarelli , Edwin R. Parra , Jaime Rogriguez-Canales , Carmen Behrens , Lixia 2 2 2 2 2 2 2 Diao , Jorge Blando , Jing Wang , Lauren A. Byers , Ignacio I. Wistuba , Padmanee Sharma , James P. Allison , John 2 1 2 V. Heymach . City of Hope Comprehensive Cancer Center, Duarte, CA; The University of Texas MD Anderson Cancer Center, Houston, TX. A085 Immune evasion and PD-1-positive T cell infiltration in DNA mismatch repair-deficient colorectal 1 1 2 2 3 1 cancer. Matthias Kloor , Jonas Janikovits , Julia Krzykalla , Axel Benner , Niels Grabe , Fabian Echterdiek , Meike 1 1 1 1 1 Mueller , Sandrina Koerner , Aysel Ahadova , Magnus von Knebel Doeberitz . University of Heidelberg, 2 3 Heidelberg, Germany; Division of Biostatistics, DKFZ Heidelberg, Heidelberg, Germany; Hamamatsu Tissue Imaging and Analysis (TIGA) Center, Bioquant, Heidelberg, Germany. A086 EMT produces an immunosuppressive tumor microenvironment. Limo Chen, Yanyan Lou, Ignacio Wistuba, Stephen Ullrich, Xiao-Feng Qin, Lauren Byers, John Heymach, Don Gibbons. UT MD Anderson Cancer Center, Houston, TX. 1
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A087 Quantifying the landscape of immunostimulatory tumoral RNA. Alexander Solovyov , Antoine Tanne , 1 2 2 3 4 1 Luciana Muniz , Simona Cocco , Remi Monasson , Arnold Levine , David T. Ting , Nina Bhardwaj , Benjamin 1 1 2 Greenbaum . Icahn School of Medicine at Mount Sinai, New York, NY; Ecole Normale Superieure, Paris, France; 3 4 Institute for Advanced Study, Princeton, NJ; Massachusetts General Hospital, Boston, MA. A088 Immune profiling of inflamed microsatellite stable colorectal cancer. Nicolas Jose Llosa, Franck Housseau, Nicholas Siegel, Kellie N. Smith, Hongni Fan, Robert M. Anders, Dung Le, Luis Diaz, Jr., Cynthia Sears, Drew M. Pardoll. Johns Hopkins Medical Institutes, Baltimore, MD. A089 Multiparametric immunofluorescence analysis of the tumor microenvironment using CODEX. Julia Kennedy-Darling, Garry P. Nolan, Yury Goltsev, Nikolay Samusik. Stanford University School of Medicine, Stanford, CA. A090 Identify molecular mechanisms that regulate the GMP-AMP synthase (cGAS) activity. Tuo Li, Zhijian J. Chen. UT Southwestern Medical Center, Dallas, TX.
Poster Session A Sunday, September 25, 5:00 p.m.-7:30 p.m. Posters A001-A075: Americas Hall I, New York Hilton Midtown Posters A076-A148: Americas Hall II, New York Hilton Midtown A091 Specific myelomonocytic cells heavily infiltrate orthotopic lung tumors and display a hypoxia-driven miRNA expression signature that directs tumor-supporting functions and negatively impacts on clinical 1 2 2 2 1 outcome. Elisabeth Brabants , Lotte Pyfferoen , Celine Everaert , Simon Tavernier , Kelly Heyns , Nancy De 1 1 2 1 2 2 Cabooter , Glenn Wagemans , Kim Deswarte , Hamida Hammad , Olivier De Wever , Jo Vandesompele , Bart 2 2 1 1 2 Lambrecht , Pieter Mestdagh , Karim Vermaelen . Ghent University Hospital, Ghent, Belgium; Ghent University, Ghent, Belgium. A092 Comprehensive multidimensional analysis of the immune contexture in non-small cell lung 1 1 1 1 1 1 cancer. Romain Remark , Yonit Lavin , Adeeb Rahman , Camille Bigenwald , Soma Kobayashi , Christian Becker , 2 1 1 1 2 Raja Flores , Sacha Gnjatic , Miriam Merad . Icahn School of Medicine at Mount Sinai, New York, NY; The Mount Sinai Hospital, New York, NY. A093 Impact of antigen affinity on T cell dysfunction in solid tumors. Mojdeh Shakiba, Mary Philip, Andrea Schietinger. Memorial Sloan Kettering Cancer Center, New York, NY. A094 mPGES1 deletion increases tumor susceptibility to immune suppression. Nune Markosyan, Andrew Rech, Robert Vonderheide. University of Pennsylvania, Philadelphia, PA. A095 Immunosuppressive plasmocytes regulate the development of NASH-induced HCC. Shabnam Shalapour, Michael Karin. UCSD, La Jolla, CA. A096 Myeloid cells are required for pancreatic carcinogenesis and PD-1/PD-L1 checkpoint activation. Yaqing 1 1 1 1 1 1 1 Zhang , Ashley Velez-Delgado , Esha Mathew , Dongjun Li , Flor M. Mendez , Kevin Flannagan , Andrew D. Rhim , 1 2 1 1 Diane M. Simeone , Gregory L. Beatty , Marina Pasca di Magliano . University of Michigan, Ann Arbor, MI; 2 University of Pennsylvania, Philadelphia, PA. 1
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A097 Tumor PDL1 blocks CTL cytotoxicity. Kathleen A. McGuire , Vikram R. Juneja , Robert T. Manguso , Martin 1 3 3 4 5 1 W. LaFleur , Natalie Collins , W. Nicholas Haining , Gordon J. Freeman , Arlene H. Sharpe . Harvard Medical 2 3 School, Boston, MA; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children's Hospital, Harvard 4 Medical School, Boston, MA; Harvard Medical School, Department of Medical Oncology, Dana-Farber Cancer 5 Institute, Boston, MA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA. 1
A098 A role for fibrosis in promoting pro-tumor immune response in breast cancer. Ori Maller , Luke 1 1 2 1 1 3 4 Cassereau , Allison Drain , Brian Ruffell , Irene Acerbi , Miranda Broz , Jennifer Munson , Melody Swartz , 1 5 1 1 2 Matthew Krummel , Lisa Coussens , Valerie Weaver . UCSF, San Francisco, CA; Moffitt Cancer Center, Tampa, FL; 3 4 5 University of Virginia , Charlottesville, VA; University of Chicago, Chicago, IL; Oregon Health & Sciences University, Portland, CA. 1
A099 Inflammation mediates profound changes to the immunopeptidome of melanoma. Katherine Woods , 2 2 1 1 1 Ralf B. Schittenhelm , Anthony W. Purcell , Andreas Behren , Jonathan Cebon . Olivia Newton-John Cancer 2 Research Institute, Melbourne, Australia; Dept. of Biochemistry and Molecular biology, Monash University, Melbourne, Australia.
Poster Session A Sunday, September 25, 5:00 p.m.-7:30 p.m. Posters A001-A075: Americas Hall I, New York Hilton Midtown Posters A076-A148: Americas Hall II, New York Hilton Midtown A100 Crosstalk between regulatory T cells and tumor-associated dendritic cells controls antitumor immunity in 1 1 1 2 1 1 pancreatic cancer. Jung-Eun Jang , Cristina H. Hajdu , George Miller , Michael L. Dustin , Dafna Bar-Sagi . NYU 2 School of Medicine, New York, NY; Kennedy Institute, University of Oxford, Oxford, United Kingdom. A101 Role of TIM-3/Galectin-9 pathway in lung cancer. Yoshihiro Ohue, Koji Kurose, Yumi Nishio, Midori Isobe, Mikio Oka, Eiichi Nakayama. Kawasaki Medical School, Kurashiki, Okayama, Japan. 1
A102 The fat in ovarian cancer: Immune-dependent tumor-promoting effects . Meggy Suarez-Carmona , Anita 1 2 1 2 3 1 1 Heinzelmann , Nektarios A. Valous , Mareike Hampel , Anna Berthel , Sarah Schott , Inka Zörnig , Dirk Jäger , Niels 1 1 2 Halama . National Center for Tumor Diseases, Heidelberg, Germany; Applied Tumor Immunity Clinical Cooperation Unit, National Center for Tumor Diseases, German Cancer Research Center, Heidelberg, Germany; 3 Heidelberg University Hospital, Heidelberg, Germany. A103 CCR2-CCL2 signaling is essential for macrophage recruitment to gliomas. Alexander D. Bungert, Susan Brandenburg, Matthäus Felsenstein, Ruth M. Urbantat, Annett Müller, Peter Vajkoczy. Department of Neurosurgery, Charité - Universitätsmedizin Berlin, Berlin, Germany. A104 T cell-mediated immune surveillance is inhibited by tumor-intrinsic signaling. Stefani Spranger, Thomas F. Gajewski. The University of Chicago, Chicago, IL. A105 Characterization of adenosine producing B cells in patients with head and neck cancer as well as of the influence of adenosine on B cell function. Sandra S. Jäkle, Cornelia Brunner, Thomas K. Hoffmann, Patrick J. Schuler. Deptartment of Otorhinolaryngology Head and Neck Surgery Ulm University Medical Center, Ulm, Germany. A106 Src family kinases modulate local inflammatory responses via STAT3 and MMP9 in colorectal cancer patients. Antonia Kathryn Roseweir, Arfon GNT Powell, James Park, Donald C. McMillan, Joanne Edwards. University of Glasgow Institute of Cancer Sciences, Glasgow, United Kingdom. A107 Inhibition of CCR2 potentiates the checkpoint inhibitor immunotherapy in pancreatic cancer. Heiyoun Jung, Linda Ertl, Christine Janson, Thomas Schall, Israel Charo. ChemoCentryx, Mountain View, CA. A108 CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy. Hans Nijman, Fenne Komdeur, Maartje Wouters, Hagma Workel, Kim Brunekreeft, Annechien Plat, Florine Eggink, Bea Wisman, Toos Daemen, Evelien Duiker, Harry Hollema, Marco de Bruyn. University Medical Center Groningen, Groningen, Netherlands. A109 Immune profiling of tumor infiltrating lymphocyte subsets, myeloid cells and HPV status of HNSCC 1 2 1 1 1 biopsies using multiplex immunofluorescence. Matt Levin , Mark Lingen , David Schwartz , Helen Snyder . Cell 2 IDx, San Diego, CA; University of Chicago, Chicago, IL.
Poster Session A Sunday, September 25, 5:00 p.m.-7:30 p.m. Posters A001-A075: Americas Hall I, New York Hilton Midtown Posters A076-A148: Americas Hall II, New York Hilton Midtown A110 Detailed resolution analysis reveals spatial heterogeneity of T cell distribution in the invasive margin of 1 2 2 3 colorectal cancer liver metastases. Anna Berthel , Inka Zoernig , Meggy Suarez-Carmona , Christoph Kahlert , Fee 4 4 3 1 2 1 Klupp , Alexis Ulrich , Juergen Weitz , Dirk Jaeger , Halama Niels . National Center for Tumor Diseases and 2 German Cancer Research Center, Heidelberg, Germany; National Center for Tumor Diseases and University 3 4 Hospital Heidelberg, Heidelberg, Germany; University Hospital Dresden, Dresden, Germany; University Hospital Heidelberg, Heidelberg, Germany. A111 Distinct immunological landscapes of progressing and regressing solid tumors post anti-PD-1 immunotherapy. Gessa Sugiyarto, Osman Dadas, Tim Elliott, Edward James. The University of Southampton, Southampton, United Kingdom. A112 Manipulating tumor microenvironment for immunotherapy. Haidong Tang, Xiangyan Qiu, Yang Wang, Yang-Xin Fu. UT Southwestern Medical Center, Dallas, TX. A113 The pattern of hMENA isoforms is regulated by TGF-β1 in pancreatic cancer and may predict patient 1 1 1 1 2 outcome. Roberta Melchionna , Pierluigi Iapicca , Francesca Di Modugno , Paola Trono , Isabella Sperduti , Matteo 3 3 3 3 4 5 Fassan , Ivana Cataldo , Borislav C. Rusev , Rita T. Lawlor , Maria Grazia Diodoro , Michele Milella , Gian Luca 6 7 3 1 1 Grazi , Mina J. Bissell , Aldo Scarpa , Paola Nisticò . Tumor Immunology and Immunotherapy Unit, Regina Elena 2 National Cancer Institute, Rome, Italy; Biostatistics and Scientific Direction, Regina Elena National Cancer Institute, 3 Rome, Italy; ARC-NET Research Centre, Dept of Pathology and Diagnostics, University of Verona, Verona, Italy; 4 5 Pathology Unit, Regina Elena National Cancer Institute, Rome, Italy; Medical Oncology 1, Regina Elena National 6 Cancer Institute, Rome, Italy; Hepato-pancreato-biliary Surgery Unit, Regina Elena National Cancer Institute, 7 Rome, Italy; Lawrence Berkeley National Laboratory, University of California, Berkeley, CA. A114 Effect of different standard of care chemotherapeutics on anti-PD-L1 responses in syngeneic mouse tumor models. Rafael Cubas, Marina Moskalenko, Jeanne Cheung, Shiuh-Ming Luoh, Erin McNamara, Marcia Belvin, Jeong Kim, Stephen Gould. Genentech, South San Francisco, CA. A115 Tyrosine kinase inhibitor therapy modulates immune checkpoints and TCR repertoire diversity in chronic myeloid leukemia. Olli Dufva, Tiina Kasanen, Mohamed El Missiry, Judith Klievink, Hanna Lähteenmäki, Satu Mustjoki. University of Helsinki, Helsinki, Finland. A116 IgG antibody switching and clonal expansion in melanoma and normal skin microenvironments. Louise 1 1 1 2 1 1 Saul , Kristina M. Ilieva , Heather J. Bax , Panagiotis Karagiannis , Isabel Correa , Irene Rodriguez-Hernandez , 1 1 1 1 3 3 Debra H. Josephs , Isabella Tosi , Isioma U. Egbuniwe , Sara Lombardi , Silvia Crescioli , Carl Hobbs , Federica 3 1 4 4 5 3 3 Villanova , Anthony Cheung , Jenny LC Geh , Ciaran Healy , Mark Harries , Victoria Sanz-Moreno , David Fear , 1 1 3 1 1 James F. Spicer , Katie E. Lacy , Frank O. Nestle , Sophia N. Karagiannis . King's College London, London, United 2 3 Kingdom; University Hospital Hamburg Eppendorf, Hamburg, Germany; king's College London, London, United 4 5 Kingdom; Guy’s, King’s, and St. Thomas’ Hospitals, London, United Kingdom; Clinical Oncology, Guy’s and St. Thomas’ NHS Foundation Trust, London, United Kingdom. A117 CXCR1 is required for neutrophil recruitment to wounds and Kras-transformed cells in zebrafish. Davalyn 1 2 1 1 2 Powell , Qing Deng , Anna Huttenlocher . University of Wisconsin-Madison, Madison, WI; Purdue University, West Lafayette, IN.
Poster Session A Sunday, September 25, 5:00 p.m.-7:30 p.m. Posters A001-A075: Americas Hall I, New York Hilton Midtown Posters A076-A148: Americas Hall II, New York Hilton Midtown A118 CD103+/PD-1+ T-cells identify a subset of triple-negative breast cancer eligible for targeted checkpoint inhibition. Giulia Bottai, Massimo Roncalli, Libero Santarpia. Humanitas Clinical and Research Institute, Milan, Italy. A119 CCL3 in the tumor microenvironment augments antitumor immune priming in the lymph node. Frederick Allen, Joseph M. Nthale, Saada K. Eid, Peter Rauhe, David Askew, Jay Myers, Alexander Tong, Alex Y. Huang. Case Western Reserve University, Cleveland, OH. A120 The infiltration of Th17 cells in tumor microenvironment negatively correlate with the prognosis of the patients with head and neck squamous cell carcinoma. Jan Boucek, Michal Zabrodsky. Charles University in Prague, Prague, Czech Republic. A121 Analysis of tumor microenvironment identifies pathways predicting response to checkpoint control inhibitors: A case study comparing the immune microenvironment of uveal melanoma vs skin cutaneous melanoma. Ravi Gupta, Nitin Mandloi, Ashwini Patil, Malini Manoharan, Rekha Sathian, Kiran V. Paul, Amitabha Chaudhuri. MedGenome Inc., Foster City, CA. A122 An investigation into potential immune priming of the tumor microenvironment with FOLFOX chemotherapy in locally advanced rectal cancer. Campbell S. Roxburgh, Jinru Shia, Efsevia Vakiani, Tanisha Daniel, Martin R. Weiser. Memorial Sloan Kettering Cancer Center, New York, NY. A123 Modulation of immune cell trafficking into human colorectal cancer by gut microbiota. Eleonora 1 1 2 1 1 Cremonesi , Francesca Amicarella , Jesus Francisco Glaus Garzon , Valeria Governa , Manuele Giuseppe Muraro , 1 1 3 1 1 2 Valentina Mele , Elisabetta Padovan , Daniel Oertli , Paul Zajac , Giulio Cesare Spagnoli , Lubor Borsig , 1 1 2 3 Giandomenica Iezzi . University of Basel, Basel, Switzerland; University of Zürich, Zürich, Switzerland; University Hospital Basel, Basel, Switzerland. 1
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A124 Protumoral effects of TLR7 in lung tumors. Marion Dajon , Kristina Iribarren , Isabelle Cremer . INSERM 2 UMRS1138, Centre de Recherche des Cordeliers, Paris, France; INSERM UMRS1138, Centre de Recherche des Cordeliers, Paris, France. +
A125 Unbiased characterization of CD4 -T-helper-cell subsets leads to novel understanding heterogeneity and plasticity of tumor infiltrating lymphocytes. Sophie L.G. Kollbeck, Julia -K. Baukloh, Leonie Brockmann, Babett Steilich, Theodora Agalioti, Samuel Huber, Jakob Izbicki, Nicola Gagliani. University of Hamburg Medical Institutions, Hamburg, Germany. A126 The role of macrophages and monocytes during cancer cell extravasation in 3D vascularized microfluidic models. Alexandra Boussommier-Calleja, Roger D. Kamm. Massachussetts Institute of Technology, Cambridge, MA. A127 The role of macrophages in tissue homeostasis. Ruth A. Franklin, Scott D. Pope, Ruslan Medzhitov. Yale University School of Medicine, New Haven, CT. A128 Imprime PGG, a novel, clinical-stage pathogen associated molecular pattern, modulates MDSC function, facilitating a coordinated antitumor immune response. Kathryn Fraser, Anissa Chan, Xiohong Qiu, Nadine Ottoson, Adria Bykowski Jonas, Jeremy Graff, Nandita Bose. Biothera, Eagan, MN.
Poster Session A Sunday, September 25, 5:00 p.m.-7:30 p.m. Posters A001-A075: Americas Hall I, New York Hilton Midtown Posters A076-A148: Americas Hall II, New York Hilton Midtown A129 Ablation of neuropilin 1 from glioma associated macrophages and microglia slows tumor 1 1 1 1 1 progression. Jeremy T. Miyauchi , Danling Chen , Matthew Choi , Jillian Nissen , Kenneth Shroyer , David 2 1 1 2 Selwood , Stella E. Tsirka . Stony Brook University, Stony Brook, NY; University College London, London, United Kingdom. A130 The association between markers of tumor cell metabolism, the tumor microenvironment, and outcomes in patients with colorectal cancer. Stephen T. McSorley, Jennifer Clark, Hester C. van Wyk, Paul G. Horgan, Donald C. McMillan, Joanne Edwards, James H. Park. University of Glasgow, Glasgow, United Kingdom. A131 B7-H1 identifies tumor-reactive effector CD8 T cells susceptible of deletion by agonist PD-L1 antibodies. Siyu Cao, Xin Liu, Xiaosheng Wu, Aaron Mansfield, Haidong Dong. Mayo Clinic College of Medicine, Rochester, MN. A132 Multi-parametric profiling of non-small cell lung cancers reveals distinct immunophenotypes. Patrick Lizotte, Elena Ivanova, Mark Bittinger, Kwok-Kin Wong. Dana-Farber Cancer Institute, Boston, MA. A133 Micrometastatic progression of pancreas cancer: Murine model. Ankit Patel, Brian Belt, Nathania Figueroa, Sapna Patel, Aditi Murthy, Kelli Connolly, Scott Gerber, David Linehan. University of Rochester Medical Center, Rochester, NY. A134 Identification of novel Treg-specific molecule targets. Jung-Ho Kim, Jae-Seung Moon, Sang-Kyou Lee. Yonsei University, Seoul, Korea. A135 Novel immunotherapy for intractable pancreatic cancer focusing on the myeloid derived suppressor cells in the tumor microenvironment. Takahiro Tsuchikawa, Shintaro Takeuchi, Toru Nakamura, Mizuna Takahashi, kazuho Inoko, Toshihiro Kushibiki, Koji Hontani, Masato Ono, Shota Kuwabara, Toshiaki Shichinohe, Satoshi Hirano. Gastroenterological Surgery II, Hokkaido University, Sapporo, Japan. INK4a
A136 p16 status of primary tumor modulates local immune response in vulvar squamous cell carcinoma. Jacek J. Sznurkowski, Anton Zawrocki. Medical University of Gdansk Poland, Gdansk, Poland.
A137 PD-L1 antibodies induce macrophage phenotypic and functional activation. Genevieve Hartley, William Wheat, Jonathan Coy, Steven Dow. Colorado State University, Fort Collins, CO. G12D
A138 Increased CD3(+) cell infiltration during pancreatic intraepithelial neoplasia progression in Kras /Pdx1Cre transgenic mouse model. Xiafei Hong, Hongmei Dai, Xianze Wang, Feng Tian, Wenming Wu, Yupei Zhao. Peking Union Medical College Hospital, Beijing, China. A139 Antitumor effects of improved DC vaccine with ALA-PDT induced immunogenic apoptotic cells for skin 1 1 1 1 1 squamous cell carcinoma in mice. Haiyan Zhang , Guolong Zhang , Zhixia Fan , Xiaojie Wang , Lei Shi , Degang 1 2 2 2 1 1 Yang , Cody F. Bahavar , Feifan Zhou , Wei R. Chen , Xiuli Wang . Shanghai Skin Disease Hospital, Shanghai, China; 2 Biophotonics Research Laboratory, Center for Interdisciplinary Biomedical Education and Research, University of Central Oklahoma, Edmond, OK.
Poster Session A Sunday, September 25, 5:00 p.m.-7:30 p.m. Posters A001-A075: Americas Hall I, New York Hilton Midtown Posters A076-A148: Americas Hall II, New York Hilton Midtown A140 Check point inhibitor modulation of tumor microenvironment at orthotopic and metastatic sites using 1 bioluminescent syngeneic cell line models in immune competent mice. Andrew McKenzie , Nektaria 1 1 1 1 2 2 1 Papadopoulou , Simon Jiang , Jane Wrigley , Kelly Jones , Russell Garland , Neil Williams , Rajendra Kumari . 1 2 Crown Bioscience UK, Loughborough, United Kingdom; KWS Biotest, Bristol, United Kingdom. A141 Prognostic value of cancer stem cells (CSC) in head and neck squamous carcinoma (HNSCC). Michal Zabrodsky, Jan Bouček. Charles University in Prague, Prague, Czech Republic. A142 Pre-operative assessment of the tumor microenvironment of patients undergoing resection of colorectal cancer is feasible using colonoscopic biopsies. James H. Park, David Mansouri, Clare Orange, Joanne Edwards, Paul G. Horgan, Donald C. McMillan, Campbell SD Roxburgh. University of Glasgow, Glasgow, United Kingdom. A143 4-methylumbelliferone and interleukin-12 combined therapy inhibit tumor growth by inducing antitumor immunity and reducing the presence of cancer stem cells in an murine hepatocellular carcinoma model associated with fibrosis. Mariana Malvicini, Marcelo M. Rodriguez, Esteban J. Fiore, Juan Bayo, Mariana Garcia, Sofia Gomez Bustillo, Catalina Atorrasagasti, Estanislao Peixoto, Guillermo Mazzolini. Instituto de Investigaciones en Medicina Traslacional,Universidad Austral-CONICET, Derqui-Pilar, Argentina. A144 Urease-mediated alkalization of tumor microenvironment and its effects on T cell proliferation, cytokine release, and PD-1/PD-L1 interactions. Wah Yau Wong, Baomin Tian, Praveen Kumar, Kim Gaspar, Steve Demas, Sven Rohmann, Heman L. Chao. Helix BioPharma Corp., Aurora, ON, Canada. A145 The prognostic significance of programmed cell death-ligand 1 expression in pulmonary squamous cell carcinoma. Jung-Jyh Hung, Yu-Chung Wu, Wen-Hu Hsu. Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan. A146 Increase antitumor activity of immunotherapy by blocking colony stimulating factor 1 receptor and tropomyosin receptor kinase. Stephen Mok, Colm Duffy, Reginald Du, James P. Allison. University of Texas MD Anderson Cancer Center, Houston, TX. A147 Differential transcriptional profiling of tumor cell populations. Sascha H. Duttke, Christopher K. Glass. UCSD, La Jolla, CA. A148 Control of regulatory T (Treg) cell function by protein kinase C-eta (PKCη): A novel target for cancer immunotherapy. Christophe Pedros, Kok-Fai Kong, Amnon Altman. La Jolla institute for Allergy and Immunology, La Jolla, CA.