JOURNAL TRANSCRIPT

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Chung et al. Cardiovasc Diabetol (2016) 15:1 DOI 10.1186/s12933-015-0324-y

ORIGINAL INVESTIGATION

Cardiovascular Diabetology Open Access

Circulating angiopoietin‑like protein 8 (ANGPTL8) and ANGPTL3 concentrations in relation to anthropometric and metabolic profiles in Korean children: a prospective cohort study Hye Soo Chung1, Min Jung Lee1, Soon Young Hwang2, Hyun Jung Lee1, Hye Jin Yoo1, Ji‑A Seo1, Sin Gon Kim1, Nan Hee Kim1, Sei Hyun Baik1, Dong Seop Choi1, Seon Mi Kim3 and Kyung Mook Choi1*

Abstract  Background:  Previous studies have shown that angiopoietin-like protein 8 (ANGPTL8), also called as betatrophin, acts together with ANGPTL3 to regulate lipid metabolism, glucose metabolism, and energy homeostasis. Moreover, ANGPTL8 promotes proliferation of pancreatic β-cells and induces insulin secretion. However, there are no previous longitudinal studies in humans. Methods:  We analyzed the age- and sex-matched data of 240 normal weight and overweight Korean children from the Korean Metabolic disorders and Obesity Study in Elementary School children (K-MOSES), a prospective observa‑ tional cohort study. Results:  At baseline, ANGPTL8 concentrations were positively associated with triglycerides (TG) (r = 0.168, P = 0.010), whereas ANGPTL3 levels were associated with fasting insulin (r = 0.248, P