JOURNAL TRANSCRIPT

---

LAWRENCE G. LENKE, M.D. Professor of Orthopedic Surgery with Tenure Chief, Division of Spinal Surgery Chief of Spinal Deformity Surgery Columbia University Medical Center College of Physicians and Surgeons Surgeon-in-Chief The Spine Hospital New York Presbyterian/The Allen Hospital 5141 Broadway, 3FW-022 New York, NY 10034

www.spinal-deformity-surgeon.com TABLE OF CONTENTS I. II. III. IV. V. VI. VII. VIII. IX. X. XI. XII. XIII. XIV. XV. XVI. XVII.

Demographics/Professional Experience/Activities Honors/Awards/Scientific Recognition/Travelling Fellowships Grant/Research Support Fellowship Program/International Visiting Surgeon Program Editorial Responsibilities Course Chairman Peer Reviewed Publications Non-Peer Reviewed (Invited) Publications  Journal Articles Submitted/In Progress Book Chapters Press Releases/Newspaper/Magazine Articles/Internet National/International Societal Podium Presentations National/International Societal Posters/Exhibits Meeting/Course Faculty, Guest Lecturer/Invited Speaker Visiting Professor/Grand Rounds Instructional Manuals/Videos/Tutorials Published Abstracts Patents

2-6 6-9 9-13 13-27 27-28 28-32 32-54 54-57 57-58 58-65 65-67 67-121 121-158 158-195 195-202 202-206 206-214 214-215 11/9/2016

Curriculum Vitae

LAWRENCE G. LENKE, M.D. Surgeon-in-Chief The Spine Hospital New York Presbyterian/The Allen Hospital 5141 Broadway, 3FW-022 New York, NY 10034 www.spinal-deformity-surgeon.com I. DEMOGRAPHICS Place of Birth Harvey, IL Marital Status Married: Beth (M.H.A. Washington University-St. Louis) Children: Lauren, Bradley & Erin Education Medical School

Undergraduate

Northwestern University Medical School Chicago, IL M.D., 1986 Alpha Omega Alpha University of Notre Dame Notre Dame, IN B.S., Pre-Professional Studies, 1982 Summa cum Laude Phi Beta Kappa

GRADUATE CLINICAL EXPERIENCE Internship

Washington University School of Medicine St. Louis, MO General Surgery July 1986 – June 1987

Residency

Washington University School of Medicine St. Louis, MO Orthopaedic Surgery July 1987 – June 1991 Shriners Hospital for Children St. Louis, MO Pediatric Orthopaedics July 1987 – June 1991

Fellowship

Washington University School of Medicine St. Louis, MO Pediatric & Adult Spinal Surgery July 1991 – June 1992

-2-

Licensure Diplomat of National Board of Medical Examiners MO MD R5P11 NY MD Board Certification American Board of Orthopaedic Surgery 2014 Recertified 2004 Recertified 1994 Certified Academic Appointments July 1, 2015 – Present Professor of Orthopedic Surgery with Tenure Chief of Spinal Surgery Chief of Spinal Deformity Surgery Co-Director, Adult and Pediatric Comprehensive Spine Surgery Fellowship Columbia University Medical Center August 2012 – June 30, 2015 Director, Advanced Deformity Fellowship Department of Orthopaedic Surgery Washington University-St. Louis January 2012 – June 30, 2015 Chief, Spinal Surgery Department of Orthopaedic Surgery Washington University-St. Louis 2006 – June 30, 2015 Professor, Neurological Surgery Department of Neurologic Surgery Washington University-St. Louis August 2005 – August 2006 Co-Director, Orthopaedic Surgery Residency Program Department of Orthopaedic Surgery Washington University-St. Louis January 2004 – June 30, 2015 Co-Director, Spinal Deformity Service Department of Orthopaedic Surgery Washington University-St. Louis August 2001 – June 30, 2015 Jerome J. Gilden Distinguished Professor of Orthopaedic Surgery Department of Orthopaedic Surgery Washington University-St. Louis January 2001 – August 2001 Professor, Orthopaedic Surgery Department of Orthopaedic Surgery Washington University-St. Louis September 1999 – August 2005 Director, Orthopaedic Surgery Residency Program Department of Orthopaedic Surgery Washington University-St. Louis

-3-

March 1998 – January 2001 Associate Professor (tenure) Department of Orthopaedic Surgery Washington University-St. Louis August 1993 – February 2012 Chief, Spinal Surgery Shriners Hospital for Children – St. Louis Unit July 1992 – July 1997 Assistant Professor Department of Orthopaedic Surgery Washington University-St. Louis July 1991 – June 1992 Instructor Department of Orthopaedic Surgery Washington University-St. Louis Hospital Appointments Surgeon-in-Chief The Spine Hospital New York-Presbyterian/The Allen Hospital NewYork-Presbyterian Morgan Stanley Children's Hospital Administrative Duties/Special Programs Fellowship Program Visiting Surgeon Program Societal Memberships American Academy of Orthopaedic Surgeons American Orthopaedic Association American Spinal Injury Association AOSpine International Missouri State Orthopaedic Association North American Spine Society Orthopaedic Research Society Pediatric Orthopaedic Society of North America Scoliosis Research Society St. Louis Guild of the Catholic Medical Association St. Louis Spine Society The Scoliosis Association Societal Committees American Academy of Orthopaedic Surgeons 2010-2013 Board of Specialty Societies, Representative 2014-Present Academy Member Volunteer American Orthopaedic Association 2001-2004 ABC Exchange Fellowship Committee 2000-2009 Publications Committee AOSpine International 2012-2015 Knowledge Forum Deformity Steering Committee, Chairman 2016- Present Knowledge Forum Deformity Steering Committee, Member Group International Cotrel-Dubousset 2000-2002 Board Member -4-

National Spine Network 1997-2004 Executive Committee 1997-1999 Quality Assurance Committee, Chair 1996-2002 Membership Committee 1995-2004 Attending Spine Surgeon North American Spine Society 2011-2012 Education Council Committee 2009-2011 Spine Summit Steering Committee, SRS Liaison Orthopedic Research and Eduction Foundation 2015-Present Board of Directors Research Society 2012-2014 2012-2014 2013-2014 2013-2014 2013-2014 2012-2014 2012-2013 2011-2012 2011-2012 2011-2012 2011-2012 2011-2012 2011-2012 2011-2012 2011-2012 2011-2012 2011-2012 2011-2012 2011-2012 2011-2012 2011-2012 2011-2012 2011-2012 2011-2012 2010-2012 2010-2012 2010-2012 2010-2012 2010-2011 2010-2011 2010-2011 2010-2011 2010-2011 2010-2011 2009-2014 2009-2010 2009-2013 2009-2012 2009-2010 2009-2010 2009-2010 2009-2010 2009-2010 2008-2014 2008-2013

CME Committee Development Committee 3D Scoliosis Task Force Education Committee, Cadaver Course Liaison Governance Council, Globalization Globalization Committee, Chair Long Range Planning Committee, Past Chair 3D Scoliosis Committee, Board Liaison Board of Directors, PPI CME Committee, PPI Corporate Relations Committee, Chair Endowment Committee, PPI E-Text Committee, Board Liaison Finance Committee, PPI Finance Council, Long Range Planning Liaison Globalization Committee, Chair Governance Council, Industry Relations Liaison IMAST Committee, Board Liaison Industry Relations Committee, Chair Long Range Planning Committee, Chair Long Range Planning Committee, Board Liaison Multi-Society Spine Registry Task Force, Chair Nominating Committee, Chair Development Committee, PPI Adult Deformity Classification Task Force Directed Research Task Force Journal Task Force, Chair Scoliosis Screening Task Force Board of Directors, President CME Committee, Past Chair Industry Relations Committee, Chair-Elect Long Range Planning Committee, Chair-Elect Multi-Society Spine Registry Task Force, Chair-Elect Nominating Committee, Chair-Elect E-Text Committee CME Committee, Chair Board of Specialty Societies, Representative (formerly COMSS), Health Policy 3D Scoliosis Committee Education Council, CME Representative President Elect Program Committee, IMAST Past Chair Program Committee, Program Reviewer Spine Deformity Curriculum Committee, Board Liaison Executive Committee Long Range Planning Committee -5-

2008-2012 2008-2012 2008-2011 2008-2009 2008-2009 2007-2008 2006-2009 2006-2008 2006-2013 2006-2008 2004-2010 2002-2005 2001-2012 2001-2002 2001-2002 2000-2009 2000-2001 1999-2001 1998-2008 1998-2000 1996-1998

Industry Relations Committee Advocacy & Public Policy Committee, Rapid Response Team IMAST Committee, Board Liaison, Past Chair Continuing Medical Education Committee, Chair-Elect Vice-President Morbidity & Mortality Committee Program Committee, IMAST Chair Study Group Task Force, Chair Board of Directors Long Range Planning Committee Global Outreach, Advocacy & Finance Committee Nominating Committee Finance Committee Ad Hoc Committee - International Journal of Spinal Deformity Development, Chair Outcomes Research Planning Committee, Chair International Meeting on Advanced Spine Techniques, Chair Nominating Committee Spinal Deformities Journal Committee Task Force, Chair 3D Spinal Classification Committee, Chair Core Curriculum for Spinal Deformity Task Force, Section Leader Prevalence and Natural History Committee

Spinal Deformity Education Group 2002-2003 Board Member 2002-2003 Second Vice Chair Southern Orthopaedic Association 1996-2010 Missouri Councilor 1996-2001 Young Physicians Subcommittee Study Groups 2014-Present 2011-Present 2010-2011 2009-Present 2000-2008 2000-2001 1999-2000 1996-1997 1993-2000

Setting Scoliosis Straight, Harms Study Group, DePuy Synthes Spine Fox Prospective Pediatric Vertebral Column Resection (VCR) Trial, Chair Intraoperative Neurophysiologic Monitoring (IONM) Workgroup Fox Retrospective Pediatric Vertebral Column Resection (VCR) Trial, Chair Spinal Deformity Study Group, Medtronic, Chair Young Lions Degenerative Scoliosis Spinal Surgery Study Group, Chair International Biomechanical Spine Study Group BAK Fusion Cage Study Group for PLIF Applications, DePuy AcroMed Corporation Harms Anterior vs. Posterior Thoracic Scoliosis Instrumentation Study Group

II. HONORS/AWARDS/SCIENTIFIC RECOGNITION/TRAVELLING FELLOWSHIPS 2016

2016 2016 2015 2015

2015

2015 2013

Russell A. Hibbs Clinical Award, Best Clinical Presentation Runner-up: Neurologic Complications Following Complex Adult Spinal Deformity Surgery: 2 Year Follow-up of the Scoli-Risk 1 Prospective, Multicenter, International Study.51st SRS Annual Meeting & Course Prague, Czech Republic 23rd IMAST Thomas E. Whitecloud Award for Best Clinical Paper: Incidence of Proximal Junctional Kyphosis in Patients with Adult Spinal Deformity Fused to the Pelvis: A ScoliRisk-1 Sub-analysis AANS/CNS Joint Section on Disorders of the Spine and Peripheral Nerves : Meritorious Service AwardOrthopaedic Surgery New York Super Doctors 2016 list, The New York Times, May 15, 2016 issue Best Clinical Paper: Pre-operative Predictors of Neurological Motor Decline in Complex Adult Spinal Deformity Surgery: Results of Prospective, International, Multicenter Scoli-RISK-1 Study in 271 Patients. 22nd International Meeting on Advance Spine Techniques, Kuala Lumpur, Malaysia Best Paper: Risk Factors for Non-Neurological Complications in Adult Spinal Deformity Surgery: An International Large-Scale, Prospective Multi-Center Study. Global Spine Annual Meeting, Buenos Aires, Argentina Achievement Award for Volunteerism American Academy of Orthopaedic Surgeons Annual Meeting, Las Vegas, Nevada The Top 28 Spine Surgeons in North America, Orthopedics This Week Volume 9, Issue 20 -6-

2013 2013 2013

2012

2012

2012 2011

2011 2011

2011 2011 2008-2010 2008-2010 2008

2007

2005-2015 2005

2003 2000 2000 2000 2000-2015 1999 1999 1998 1998 1997

1995 1995

Top 10% Rank: Patient Survey for Clinicians, Washington University Physicians Leon Wiltse Award for Excellence in Leadership and/or Clinical Research in Spine Care, North American Spine Society 28th Annual Meeting, New Orleans, LA Russell A. Hibbs Clinical Award, Best Clinical Paper: Prospective, Multi-Center Assessment of Acute Neurologic Complications Following Complex Adult Spinal Deformity Surgery: The Scoli-Risk-1 Trial. Scoliosis Research Society 48th Annual Meeting, Lyon, France John H. Moe Award, Best Basic Science Paper: The Ventral Lamina and Superior Facet Rule: A Morphometric Analysis for Ideal Thoracic Pedicle Screw Start Point. Scoliosis Research Society 47th Annual Meeting, Chicago, IL President’s Resident Paper Award: The Ventral Lamina and Superior Facet Rule: A Morphometric Analysis for Ideal Thoracic Pedicle Screw Start Point. Southern Orthopaedic Association 29th Annual Conference, White Sulpher Springs, WV. $1,500.00 Award Resident Paper Award: The Effect of Pedicle Screw Hubbing on Pullout Strength in the Thoracic Spine. Western Orthopaedic Association 76th Annual Meeting, Portland, OR. $1,000.00 Award Resident/Fellow Travel Grant Award, Outstanding Resident Paper: The Ventral Lamina and Superior Facet Rule: The Key to Accurate Placement for Thoracic Pedicle Screws. Eastern Orthopaedic Association 42nd Annual Meeting, Williamsburg, VA Whitecloud Award, Best Clinical Science Paper: Preoperative Vitamin D Status in Adults Undergoing Spinal Fusion Surgery. 18th Annual International Meeting on Advanced Spine Techniques, Copenhagen, Denmark Eastern Orthopaedic Association’s Travel Grant: The Ventral Lamina and Superior Facet Rule: The Key to Accurate Placement for Thoracic Pedicle Screws. Eastern Orthopaedic Association 42nd Annual Meeting, Williamsburg, VA Heartworks St. Louis, Hero with a Heart Honoree, National Marfan Association, St. Louis, MO Eduardo Luque Honorary Award, Mexican Association of Spine Surgeons, Degenerative and Deformity Spine Disease 2010 Congressional Meeting, Mexico City, Mexico Guide to America’s Top Surgeons - Consumer Guide e-book, Consumer’s Research Council of America, Washington, DC Guide to America’s Top Orthopedists - Consumer Guide e-book, Consumer’s Research Council of America, Washington, DC Louis A. Goldstein Award, Best Clinical Presentation: Risk Factors for Critical Intraoperative Neuromonitoring Changes during AIS Surgery. Scoliosis Research Society 43rd Annual Meeting, Salt Lake City, UT Russell A. Hibbs Award, Best Clinical Science Paper: Posterior Vertebral Column Resection (VCR) for Severe Pediatric & Adult Spinal Deformity: Indications, Results & Complications of 43 Consecutive Cases. Scoliosis Research Society 42nd Annual Meeting, Edinburgh, Scotland America’s Top Doctors, Castle Connolly Medical Ltd. Louis A. Goldstein Award, Best Clinical Poster: Decompression Alone vs. Decompression and Limited Fusion for the Treatment of Degenerative Lumbar Scoliosis. Scoliosis Research Society 40th Annual Meeting, Miami, FL 1st Place, Outstanding Resident/Fellow Paper Award: Thoracic Anterior Spinal Fusion and Structures at Risk. Eastern Orthopaedic Association/Southern Orthopaedic Association, Dublin, Ireland Regional Zimmer Travel Award. American Orthopaedic Association 113th Annual Meeting, Hot Springs, VA Best Clinical Research Paper, Annual Residents Conference. American Orthopaedic Association, St. Louis, MO Life member of the National Who’s Who Registry Best Doctors in America – St. Louis Magazine Outstanding Paper Award: Can Nerve Root Injections Obviate the Need for Operative Treatment? North American Spine Society 14th Annual Meeting, Chicago, IL American, British, Canadian (ABC) Exchange Fellowship Program Award participant. American Orthopaedic Association Best Doctors in America – 4th listing, Woodward/White, Inc. Lee T. Ford Academic Achievement 2nd Annual Award, Washington University Medical Center, St. Louis, MO Russell A. Hibbs Award, 1st Runner-up, Best Clinical Research Paper: A Prospective Evaluation of Pulmonary Function in Adolescent Idiopathic Scoliosis Relative to the Surgical Approach for Spinal Fusion. Scoliosis Research Society 32nd Annual Meeting, St. Louis, MO John H. Moe Award, Best Scientific Poster: Can We Lordose the Spine with Zielke Instrumentation Anteriorly? Scoliosis Research Society 30th Annual Meeting, Asheville, NC European Traveling Fellowship Award participant. Scoliosis Research Society 30th Annual Meeting, Asheville, NC -7-

1994

Spinal Surgery Paper Award for Fellows and Residents: TGF-Beta treatment of spinal cord monitoring. Group International Cotrel-Dubousset-USA 11th International Congress, Arachon, France 1993 Research Grant Winner: Astrocyte Response and Transforming Growth Factor-β Localization in Acute Spinal Cord Injury. North American Spine Society 8th Annual Meeting, San Diego, CA 1992 Best Resident/Fellow Paper: The Surgical Treatment of Lumbar Hemivertebra. Missouri State Orthopaedic Association Annual Meeting, Lake of the Ozarks, MO 1991 Russell A. Hibbs Award, Best Clinical Presentation: Preventing Decompensation in King Type II and III Curves Treated with Cotrel-Dubousset Instrumentation (CDI). 24 to 64 month follow-up. Scoliosis Research Society 25th Annual Meeting, Minneapolis, MN Travelling Fellowships 1. Scoliosis Research Society European Traveling Fellowship, Scoliosis Research Society (SRS), Cappagh Orthopaedic Hospital, Dublin, Ireland, May 8, 1995. - Short segment pedicle screw constructs for thoraco-lumbar fractures 2.

Scoliosis Research Society European Traveling Fellowship, SRS, Our Lady’s Hospital for Sick Children, Crumlin, Ireland, May 9, 1995. - Short segment pedicle screw constructs for thoracal-lumbar fractures

3.

Scoliosis Research Society European Traveling Fellowship, SRS, Nuffield Orthopaedic Centre, Oxford, England, May 11, 1995. - EMG and pedicle screw placement - Spinal investigations in patients with adolescent idiopathic scoliosis with large curves - Etiology and correction of transition syndrome following spinal instrumentation

4.

Scoliosis Research Society European Traveling Fellowship, SRS, University of Malmö Hospital, Malmö, Sweden, May 15-16, 1995. - Etiology and correction of transition syndrome following spinal instrumentation - CD for AIS, 5-10 year follow-up

5.

Scoliosis Research Society European Traveling Fellowship, SRS, Langensteinbach, Germany, May 19, 1995. - Etiology and correction of transition syndrome following spinal instrumentation - CD for AIS, 5-10 year follow-up

6.

Scoliosis Research Society European Traveling Fellowship, SRS, University of Verona Hospital, Verona, Italy, May 22, 1995. - CD for AIS, 5-10 year follow-up - Sagittal spinal alignment: segmental, regional, and global perspectives

7.

Scoliosis Research Society European Traveling Fellowship, SRS, Trousseau Hospital, Paris, France, May 24, 1995. - CD for AIS, 5-10 year follow-up - Sagittal spinal alignment: segmental, regional, and global perspectives - Etiology and correction of transition syndrome following spinal instrumentation

8.

Scoliosis Research Society European Traveling Fellowship, SRS, St. Vincent DePaul Hospital, Paris, France, May 25, 1995. - CD for AIS, 5-10 year follow-up - Sagittal spinal alignment: segmental, regional, and global perspectives - Etiology and correction of transition syndrome following spinal instrumentation

9.

American, British, Canadian (ABC) Exchange Fellowship Program, American Orthopaedic Association (AOA), Stanmore Hospital, University of London, April 1999. - Intraoperative and perioperative halo traction in severe pediatric spinal deformity - Comparison of anterior vs. posterior instrumentation for correction of thoracic adolescent idiopathic scoliosis: Analysis by an objective radiographic scoring system

10. American, British, Canadian (ABC) Exchange Fellowship Program, AOA, University of Bristol, Bristol, United Kingdom, April 1999. - Algorithm approach to adolescent idiopathic scoliosis 11. American, British, Canadian (ABC) Exchange Fellowship Program, AOA, University of Manchester, Manchester, United Kingdom, April 1999. - Anterior single solid rod instrumentation for adolescent idiopathic scoliosis -8-

12. American, British, Canadian (ABC) Exchange Fellowship Program, AOA, University of Nottingham, Nottingham, United Kingdom, April 1999. - Anterior single solid rod instrumentation for adolescent idiopathic scoliosis 13. American, British, Canadian (ABC) Exchange Fellowship Program, AOA, University of Perth, Perth, Australia, May 1999. - Long fusions to the sacrum 14. American, British, Canadian (ABC) Exchange Fellowship Program, American Orthopaedic Association, University of Melbourne, Melbourne, Australia, May 1999. - Algorithm approach to adolescent idiopathic scoliosis 15. American, British, Canadian (ABC) Exchange Fellowship Program, AOA, University of Christchurch, Christchurch, New Zealand, May 1999. - Anterior single solid rod instrumentation for adolescent idiopathic scoliosis 16. American, British, Canadian (ABC) Exchange Fellowship Program, AOA, Auckland, New Zealand, May 1999. - Radiographic evaluation of anterior titanium mesh (Harms) cages

III. GRANT/RESEARCH SUPPORT NON-GOVERNMENT - Current Funding Agency: EOS Imaging Period: January 1, 2014 – January 1, 2017 Grant Title: Correlating Three-Dimensional (3D) Spino-Pelvic Parameters with Two-Dimensional (2D) Traditional Imaging and HRQOL-Impact of New 3D Measures on the Evaluation of Adult Spinal Deformity Aim: Assess the clinical relevance of 3D stereographic reconstructions (EOS 3D) in the setting of adults with spinal deformity. Divergence between 2D and 3D radiographic parameters will be evaluated as well as correlations with patient reported outcomes. This prospective study could be the first one of several projects aiming to answer the following questions/key-points: · Can EOS 3D help in the identification of deformity patterns specific to axial versus radicular pain? · What additional, relevant information can EOS provide that conventional radiography cannot? · How can EOS assist a physician in his/her diagnosis, patient follow-up, or surgical planning? Investigators: Virginie Lafage PhD, (PI) Frank Schwab MD, Themistocles Protopsaltis MD, Thomas Errico MD, Lawrence G. Lenke MD, Han Jo Kim MD* Funding: ($629.00/non-operative patient, $801.00/surgical patient) Funding Agency: Period: Grant Title: Aim: Investigators: Funding: Funding Agency: Period: Grant Title:

John and Marcella Fox Foundation January 2009 – Present Fox Retrospective Pediatric Vertebral Column Resection (VCR) Trial Analyze data from a consecutive series of patients from eight institutions who have had the posterior VCR procedure to determine the efficacy and safety of this procedure. Lawrence G. Lenke MD (PI), John B. Emans MD, Peter O. Newton MD, Suken A. Shah MD, Harry L. Shufflebarger MD, Paul D. Sponseller MD, Daniel J. Sucato MD $250,000.00

Investigators: Funding:

Setting Scoliosis Straight Foundation October 1, 2013 – December 31, 2017 Scoliosis Surgery Outcome Database Registry: A Prospective, Multi-Center Database Registry of the DePuy Spine Harms Study Group (“STUDY”) Comparison of surgical outcomes. We will evaluate the pre-and postop x-ray, clinical and outcomes data that are standard of care. We will gather data as patients return at various time points through 25 years postop. There are different types of scoliosis and the goal of this study is to identify in which cases each approach has the best result. Peter O. Newton MD (PI), Lawrence G. Lenke MD (Site PI), numerous institutions $2355.00/per patient over 5 years

Funding Agency: Period: Grant Title:

John and Marcella Fox Foundation January 2011 – Present Fox Prospective Pediatric Vertebral Column Resection (VCR) Trial

Aim:

-9-

Investigators:

Funding:

Lawrence G. Lenke MD (PI), Oheneba Boachie-Adjei MD, John B. Emans MD, Munish Gupta MD, Scott J. Luhmann, Jr. MD*, Richard E. McCarthy MD, Peter O. Newton MD, David W. Polly MD, Amer Samdani MD, Suken A. Shah MD, Harry L. Shufflebarger MD, David L. Skaggs MD, Paul D. Sponseller MD, Peter F. Sturm MD, Daniel J. Sucato MD, Michael Vitale MD $1,000,000.00

NON-GOVERNMENT - Past Funding Agency: Period: Grant Title: Investigators: Funding: Funding Agency: Period: Grant Title: Investigators: Funding: Funding Agency: Period: Grant Title: Investigators: Funding: Funding Agency: Period: Grant Title: Investigators:

AOSpine International and the Scoliosis Research Society (NCT01305343) July 2011 – February 28, 2013 Evaluation of Neurologic Complications Associated with Surgical Correction of Adult Spinal Deformity (Scoli-RISK-1): A Prospective, Observational, Multi-center Study Lawrence G. Lenke MD, Michael G. Fehlings MD, Christopher I. Shaffrey MD, Kenneth M.C. Cheung MD, Leah Y. Carreon MD MSc $700,000.00 Axial Biotech, Inc. April 2008 – October 2014 Linkage Analysis and Gene Mapping of Familial Spinal Disorders (Scoliosis, Scheuermann’s Kyphosis, Spondylolisthesis, Lumbar Disc Disease, Osteoporosis) (08-0084) Lawrence G. Lenke MD, Keith H. Bridwell MD, Scott J. Luhmann, Jr. MD* $100.00/per patient Medtronic Sofamor Danek, Memphis, TN March 2005 – July 2009 Washington University Spine Research Center Keith H. Bridwell MD, Lawrence G. Lenke MD, K. Daniel Riew MD Timothy R. Kuklo JD MD* (as of 2007) $1,948,615.00

Funding:

Medtronic Sofamor Danek, Memphis, TN October 2003 – September 2008/Renewed May 2009 – July 2009 Prospective Pediatric Scoliosis Study (PPSS) (02-0689) Lawrence G. Lenke MD, Matthew B. Dobbs MD, Keith Bridwell MD, Scott J. Luhmann Jr. MD*, Timothy R. Kuklo JD MD* (as of 2007) $50,000.00 (funded in full)

Funding Agency: Period: Grant Title: Investigators: Funding:

Scoliosis Research Society, Foundation Yves Cotrel, Rosemont, IL October 2003 – September 2005 Idiopathic Scoliosis: Gene Mapping and Identification Matthew B. Dobbs MD, Michael Lovett PhD, Michael Whyte MD, Lawrence G. Lenke MD $49,177.00 (funded in full)

Funding Agency: Period: Grant Title: Investigators: Funding:

Medtronic Sofamor Danek, Memphis, TN March 2001 – February 2005 Washington University Spine Research Center Keith H. Bridwell MD, Lawrence G. Lenke MD, K. Daniel Riew MD $1,494,604.00 (funded in full)

Funding Agency: Period: Grant Title: Investigators: Funding:

Shriners Hospital COSAB Grant August 2000 (not accepted) revised January 2002 Prospective Comparison of Postoperative Range of Motion Exercise after Adolescent Idiopathic Scoliosis Fusion Jack R. Engsberg PhD, Lawrence G. Lenke MD $70,000.00

Funding Agency: Period: Grant Title:

Max-Biedermann-Institut, Berlin, Germany July 2000 – June 2001 Center of Gravity Investigation in Scoliosis

Student, ‡Resident, *Fellow, ∫Neurosurgical Resident, †Advanced Deformity Fellow, ^Domestic Visiting Surgeon, §International Research Scholar

¥

- 10 -

Investigators: Funding:

Jack R. Engsberg PhD, Lawrence G. Lenke MD, Kyongta Tye Bae MD PhD $40,440.00 (funded in full)

Funding Agency: Period: Grant Title: Investigators: Funding:

Medtronic Sofamor Danek, Memphis, TN January 2000 – December 2001 Genetic Manipulation of the Secondary Injury Cascade of Acute Spinal Cord Injury Jueren Lou PhD, F. Xu PhD, Lawrence G. Lenke MD $25,000.00 (funded in full)

Funding Agency: Period: Grant Title:

Scoliosis Research Society, Rosemont, IL October 1998 – September 2001 Comparison of Outcome Measures in Adult Scoliosis Patients Undergoing an Extended Spinal Fusion to L5 or Sacrum or Revision of Previous Long Spinal Deformity Fusion Surgery Keith H. Bridwell MD, Jack R. Engsberg PhD, Scott D. Minor PhD, Lawrence G. Lenke MD $80,308.00 (funded in full)

Investigators: Funding: Funding Agency: Period: Grant Title: Investigators:

Sofamor Danek USA, Memphis, TN October 1998 (not accepted), revised July 1999 Outcomes in Adolescents having Scoliosis Fusion Surgery Lawrence G. Lenke MD, Keith H. Bridwell MD, Jack R. Engsberg PhD, George S. Bassett MD, Sandy A. Ross MD, James S. Kemp MD, Kevin W. Hollander MS ME, Kyongta Ty Bae MD PhD, Kenneth B. Schechtman MD

Funding: Funding Agency: Period: Grant Title: Investigators: Funding:

Sofamor Danek USA, Memphis, TN August 1998 – August 2000 Structural and Performance Changes in AIS Patients Fused into the Mid and Lower Lumbar Spine Lawrence G. Lenke MD, Jack R. Engsberg PhD, James S. Kemp MD, Keith H. Bridwell MD, George S. Bassett MD $75,000.00 (funded in full)

Funding Agency: Period: Grant Title: Investigators: Funding:

Orthopaedic Research and Education Foundation (OREF), Rosemont, IL July 1998 – June 2000 Amicar versus Aprotinin in Controlling Blood Loss in Scoliosis Surgery Lawrence G. Lenke MD, George S. Bassett MD, Jennifer Cole MD $42,722.00 (funded in full)

Funding Agency: Period: Grant Title:

Ortho-Biotech, Inc., Raritan, NJ July 1998 – December 1999 An Open-Label, Randomized, Parallel-Group Study Comparing the Perioperative Administration of Procrit7 (Epoetin Alfa) to the Standard of Care in Blood Conservation for Idiopathic Pediatric/Adolescent Scoliosis and Adult Spinal Deformity Surgeries Keith H. Bridwell MD, Lawrence G. Lenke MD, Terri G. Monk MD $60,000.00 (funded in full)

Investigators: Funding: Funding Agency: Period: Grant Title: Investigators:

Funding: Funding Agency: Period: Grant Title: Investigators: Funding:

Sofamor Danek USA, Memphis, TN June 1997 – June 1999 (extended to June 2001) Biomechanics of Spinopelvic Fixation in a Human Cadaveric Model of Isthmic Spondylolisthesis Keith H. Bridwell MD, Stephen J. Lewis MD*, Ravishankar Vedantam MD, Douglas Linville MD*, John Long DVM, Bryan W. Cunningham MSc, Lawrence G. Lenke MD $50,556.00, first year; $35,000.00, second year (funded in full) DePuy-Motech, Inc., Warsaw, IN February 1997 – February 1999 Structural and Performance Changes in Adolescent Idiopathic Scoliosis Patients Undergoing Anterior vs. Posterior Thoracic Spinal Fusion Lawrence G. Lenke MD, Jack Engsberg PhD, James Kemp MD, Marilyn Siegel MD, Keith Bridwell MD $84,000.00 (funded in full)

Student, ‡Resident, *Fellow, ∫Neurosurgical Resident, †Advanced Deformity Fellow, ^Domestic Visiting Surgeon, §International Research Scholar

¥

- 11 -

Funding:

BJC Health System – Innovations in Healthcare Program, St. Louis, MO December 1996 – December 1998 Selective Nerve Root Corticosteroid Injection: Can Its Use Obviate the Need for Surgery in Patients with Lumbar Radicular Pain? K. Daniel Riew MD, Yuming Yin MD, Lawrence G. Lenke MD, Keith H. Bridwell MD, Lou Gilula MD $19,350.00 (funded in full)

Funding Agency: Period: Grant Title: Investigators: Funding:

Sofamor Danek USA, Memphis, TN August 1996 – August 1997 Retrospective and Prospective Surgical Spinal Database (~4,000 entries) Keith H. Bridwell MD, Lawrence G. Lenke MD, K. Daniel Riew MD $10,000.00 (funded in full)

Funding Agency: Period: Grant Title:

AcroMed – North American Spine Society, Rosemont, IL January 1994 – January 1995 The Role of Transforming the Growth Factor - Beta in the Spinal Cord Response to Acute Spinal Trauma Michael E. Joyce MD, Michael F. O’Brien MD*, Lawrence G. Lenke MD, Keith H. Bridwell MD $12,500.00 (funded in full)

Funding Agency: Period: Grant Title: Investigators:

Investigators: Funding:

GOVERNMENT – Current Funding Agency: Period: Grant Title:

Funding:

EOS Imaging (201310081) August 2013 – August 2014 Occipitocervical Parameters and Regional Alignment in Normal Controls using EOS Imaging Technology Lawrence G. Lenke MD, K. Daniel Riew MD, Keith H. Bridwell MD, Michael P. Kelly MD*†, Lukas P. Zebala MD‡*, Jacob M. Buchowski MD* $31,755.00

Funding Agency: Grant Title: Investigators: Funding:

2013 AOSpine North America Young Investigator Research Grant A Randomized Trial of Two Tranexamic Acid Dosing Protocols in Adult Spinal Deformity Surgery Michael P. Kelly MD*† (PI), Lawrence G. Lenke MD $30,000.00

Investigators:

GOVERNMENT – Past Funding Agency: National Institute for Health (NIH) (5U01AR4544-02) Period: July 1999 – June 2004 Grant Title: Spinal Patients Outcomes Research Trial (SPORT) - Low Back Pain: A Multi-Center Trial Investigators: James N. Weinstein DO MS, Lawrence G. Lenke MD, Keith H. Bridwell MD, K. Daniel Riew MD, Ralph Dacey MD, Carl Lauryssen MD Funding: $79,235.00 (funded in full) (part of a $14,000,000 grant) Funding Agency: Period: Grant Title: Investigators: Funding: Funding Agency: Period: Grant Title: Investigators:

National Institute for Health (NIH) (U01AR45444-01A1) May 2004 – May 2005 Spinal Patients Outcomes Research Trial (SPORT): A Multi-Center Trial Lawrence G. Lenke MD, Keith H. Bridwell MD, K. Daniel Riew MD, Ralph G. Dacey, Jr. MD, Carl Lauryssen MD, Anthony Margherita MD, Heidi Prather DO $503,252.00 locally ($13,546,017.00 nationally) (funded in full)

Funding:

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (R01 AR052113) December 2004 – December 2009 Bracing in Adolescent Idiopathic Scoliosis Treatment (BrAIST) Stuart Weinstein MD, Matthew B. Dobbs MD, Lawrence G. Lenke MD, Keith H. Bridwell MD $242,260.00 locally ($6,500,000.00 nationally)

Funding Agency:

Canadian Institutes of Health Research

Student, ‡Resident, *Fellow, ∫Neurosurgical Resident, †Advanced Deformity Fellow, ^Domestic Visiting Surgeon, §International Research Scholar

¥

- 12 -

July 2010 – July 2013 3-D Classification of Adolescent Idiopathic Scoliosis Hubert B. Labelle MD, Carl E. Aubin MD, Jean Mac-Thiong MD, Lawrence G. Lenke MD, Stefan Parent MD, Ian A. F. Stokes MD, Peter O. Newton MD, Roger P. Jackson MD $61,533.00/per year

Period: Grant Title: Investigators: Funding: Funding Agency: Grant Title: Investigators:

Funding Agency: Grant Title: Investigators:

Funding:

BJH Foundation Grant to Lawrence G. Lenke, MD (201301054) A Prospective Dose Escalation Trial of the Pharmacokinetics and Bactericidal Potency of Intrasite Lyophilized Vancomycin to Prevent Wound Infections in Instrumented Spinal Surgery Terrence F. Holekamp MD PhD∫, Lawrence G, Lenke MD, Keith H. Bridwell MD, Jacob M. Buchowski MD MS*, Michael P. Kelly MD*†, Lukas P. Zebala MD‡*, Ian G. Dorward MD∫*, Jakub Godzik BS¥, Todd J. Stewart MD, Neill M. Wright MD, Paul Santiago MD, Wilson Z. Ray MD, David D. Limbrick MD, Jeffrey R. Leonard MD, Brenda A. Sides MA, Linda A. Koester BS DoD PRORP Spinal Column Trauma: Epidemiology, Timing of Stabilization, and the Inflammatory Response to Trauma and Surgery LTC Ronald A. Lehman, Jr. MD*, Lawrence Lenke MD, Michael Kelly MD*†, Brian K. Kwon MD PhD FRCSC, Todd J. Albert MD, CPT Adam J. Bevevino MD, CPT Daniel Kang MD, COL Michael Rosner MD, David D. Limbrick Jr. MD PhD, Carlos A. Puyo MD FCCP $2,500,000.00/4 years

IV. SPINAL SURGERY FELLOWSHIP PROGRAM/VISITING SURGEON SPINAL SURGERY FELLOWSHIP PROGRAM 1992-1993 1993-1994 1994-1995 1995-1996 1996-1997 1997-1998 1998-1999 1999-2000 2000-2001 2001-2002 2002-2003 2003-2004 2004-2005 2005-2006 2006-2007 2007-2008 2008-2009 2009-2010 2010-2011 2011-2012 2012-2013 2013-2014 2014-2015 2015-2016 2016-2017

Michael F. O’Brien MD Daniel E. Gelb MD Michael P. Chapman MD; Christopher L. Hamill MD Purnendu Gupta MD; Joseph G. Marsicano MD Douglas A. Linville MD; Ravishankar Vedantam MD Kevin C. Booth MD; Robert W. Molinari MD Kevin R. Eck MD; Mark A. Lapp MD Timothy R. Kuklo MD JD; Stephen J. Lewis MD MSc FRCSC; Fred A. Sweet MD Darrell S. Hanson MD; John M. Rhee MD Charles C. Edwards, II MD; Anthony S. Rinella MD Rudolph (Chris) C. Glattes MD; Joseph R. Orchowski MD; Upshur M. Spencer MD Ivan Cheng MD; Robert K. Hurford, Jr. MD PhD; Stanley S. Lee MD Peter D. Angevine MD MPH; Robert Shay Bess MD; Scott J. Luhmann, Jr. MD Jacob M. Buchowski MD, MS; Craig A. Kuhns MD; Ronald A. Lehman, Jr. MD Geoffrey A. Cronen MD; Daniel S. Mulconrey MD; Peter S. Rose MD Christopher R. Good MD; Patrick T. O’Leary MD; Mark A. Pichelmann MD Joshua D. Auerbach MD; Michael Chang MD; Charles H. Crawford, III MD; Brian A. O’Shaughnessy MD Samuel K. W. Cho MD; Matthew M. Kang MD; Joshua M. Pahy, MD; Lukas P. Zebala MD Douglas D. Dickson MD; Michael P. Kelly MD; Ra’Kerry K. Rahman MD; Jeremy J. Stallbaumer MD Jeremy L. Fogelson MD; Stuart H. Hershman MD; Han Jo Kim MD; Addisu Mesfin MD Ian G. Dorward MD; Sang Do Kim MD MS; Brian J. Neuman MD; Kevin R. O’Neill MD MS Jeffrey L. Gum MD; David B. Bumpass MD; Isaac O. Karikari MD; Patrick A. Sugrue MD Todd Chapman MD; Daniel Kang MD; Lionel Metz MD; Jamal McClendon MD Venu Nemani MD; William R. Hotchkiss MD, Andrew Pugley, MD, Frank Valone, MD Lee Tan MD; Xudong Li MD; Alexander Tuchman MD

Advanced Deformity Fellowship (non-accredited) 6 months 2011-2012 Michael P. Kelly MD 2013-2014 Ra’Kerry Rahman MD 2014 Ronald A. Lehman, Jr. MD 2014-2015 David B. Bumpass MD 2015 Fernando E. Silva MD 2015-2016 Terrence F. Holekamp MD, PhD Student, ‡Resident, *Fellow, ∫Neurosurgical Resident, †Advanced Deformity Fellow, ^Domestic Visiting Surgeon, §International Research Scholar

¥

- 13 -

2016

Zeeshan Sardar, MD

Host Surgeon, National/International Visiting Research Scholar (≥1 year) 03/99-03/01 Yasutuga Yukawa MD PhD, Chubu Rosai Hospital, Nagoya University, Nagoya, Japan 09/00-07/06 Yongjung J. Kim MD PhD, Pundang Chung General Hospital/CHA Medical University, Sungnam City, Korea 03/01-02/03 Kotaro Satake MD PhD, Nagoya University School of Medicine, University Hospital, Showa-ku, Nagoya, Japan 03/02-02/03 Yong-Sun Cho MD PhD, University of Ulsan, College of Medicine, Songpa-ku, Ulsan, Korea 07/04-05/06 Gene Cheh MD, Chung-Ang University, College of Medicine, Sungnam, Seoul, Korea 08/04-07/05 Jun-Young Yang MD PhD, Chungnam National University Hospital, Jung-gu, Daejeon, Korea 09/05-08/06 Young-Woo Kim MD PhD, Hallym University Sacred Heart Hospital, Anyang-Si, Gyeonggi-do, Korea 09/05-08/06 Young-Bae Kim MD, Seoul Veterans Hospital, Guangdong-gu, Seoul, Korea 10/05-09/06 Kei Watanabe MD PhD, Niigata University, Niigata Prefecture, Japan 10/05-09/06 Kota Watanabe MD PhD, Keio University School of Medicine, Minato, Tokyo, Japan 06/07-06/08 Takuya Mishiro MD PhD, Takamatsu Red Cross Hospital, Takamatsu-city, Kagawa, Japan 12/07-05/10 Woojin Cho MD PhD, Korea 09/08-02/09 Zezhang Zhu MD PhD, Nanjing University Medical School, Nanjing, Jiangsu, China 01/09-01/10 Jung Sub Lee MD PhD, Pusan National University School of Medicine, Seo-ku, Pusan, Korea 09/09-09/10 Jin-Seok Yi MD, Catholic University of Korea Catholic Medical Center, St. Mary’s Hospital, Daejeon, Korea 11/09-11/10 Guangxun Hu MD, Nashan People’s Hospital of Shenzhen, Shenzhen, Guangdong, China 08/10-08/11 Woo-Kie Min MD PhD, Kyungpook National University Hospital, Daegu, Korea 09/11-09/12 Yang Xu, MD PhD, Fujian Provincial Hospital, Gulou District, Fuzhou, Fujian, China 08/12-07/13 Seung-Jae Hyun MD, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea 02/13-09/14 Yong-Chan Kim, MD, University Sacred Heart Hospital, Seoul, Korea 09/14-08/15 Chang Ju Hwang, MD, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea 10/14-09/15 Xiafang Zang MD PhD, The 3rd Xiangya Hospital, Central South University, Xiangya, China 12/14-11/15 Ke-Bing, MD PhD, The 3rd Affiliated Hospital of Southern Medical University, Guangzhou City, China Host Surgeon, National/International Visiting Research Scholar (