JOURNAL TRANSCRIPT

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Received: 9 February 2017 Accepted: 14 August 2017 Published: xx xx xxxx

Prognostic Significance of Elevated Cholestatic Enzymes for Fibrosis and Hepatocellular Carcinoma in Hospital Discharged Chronic Viral Hepatitis Patients Wen Xie1, Yang Cao2, Min Xu2, Jiangbin Wang3, Changyu Zhou3, Xingxiang Yang4, Xiaoxia Geng4, Wenhong Zhang5, Ning Li5 & Jun Cheng1 Chronic viral hepatitis (CVH) is the root cause of liver fibrosis and subsequent hepatocellular carcinoma (HCC). We conducted a cross-sectional, observational study based on medical records and primary data collection from patients with CVH who were admitted in five hospitals across China between February and September 2013 to determine the prevalence of elevated cholestatic enzymes (ALP and/or GGT above ULN) in discharged Chinese patients with CVH as a primary outcome and secondarily evaluated the relationship of these enzymes with fibrosis and disease severity. Majority of the patients (56%) had cholestatic enzyme elevation at discharge, with high prevalence of liver fibrosis (37.6% vs. 20.1%, p