JOURNAL TRANSCRIPT
Quantification of Chronic Functional Mitral Regurgitation By Automated 3-D Peak and Integrated Proximal Isovelocity Surface Area and Stroke Volume Techniques Using Real-Time 3-D Volume Color Doppler Echocardiography: In Vitro and Clinical Validation Thavendiranathan et al: Automated 3D Quantification of Mitral Regurgitation Paaladinesh Thavendiranathan, MD, MSc*1; Shizhen Liu, MD, PhD*1; Saurabh Datta, PhD2; Sanjay Rajagopalan, MD, FACC1; Thomas Ryan, MD, FACC1; Stephen R. Igo, BSc3; Matthew S. Jackson, ME3; Stephen H. Little, MD, FACC3; Nathalie De Michelis, BSN4; Mani A. Vannan, MBBS, FACC1 *
1
Co-first authors
The Ohio State University, niversity, C Columbus, ollum mbu bus, O OH, H,, 2Si H Siemens S em men ns Me M Medical diicall So Solutions olu lutiion onss US USA A Inc., Mountain View, CA, 3Th The T he Methodist Meth Me thod th odis od istt DeBakey is DeBa De Bake Ba k y Heart ke Hear He artt & Vascular ar Vasc Va scul sc ular ul ar Center, Cente ter, r Houston, Hou oust sttonn, TX, and ston 4
University of California l lifornia Irvine, Irvin inee, Orange, in Orang rang ra nge, e CA CA (PT (PT and an MAV MAV - work work was done while at OSU)
Correspondence to Mani A. Vannan MBBS FACC FAHA FASE Piedmont Heart Institute 95 Collier Road, Suite 2065, Atlanta, GA 3035 Tel: 404-605-2437 Fax : 404-609-6729 Email:
[email protected]
DOI: 10.1161/CIRCIMAGING.112.980383
Journal Subject Codes: 31, 19
1
Abstract Background—The aim of this study was to test the accuracy of an automated 3-D PISA (in vitro and patients) and stroke volume technique (patients) to assess MR severity using real-time 3-D volume color flow Doppler transthoracic echocardiography (RT-VCFD). Methods and Results—Using an in vitro model of MR, the effective regurgitant orifice area (EROA) and volume (RVol) were measured by the PISA technique using 2-D and 3-D (automated “true” 3-D PISA) transthoracic echocardiography. The mean anatomical regurgitant orifice area (0.35±0.10cm2) was underestimated to a greater degree by the 2-D (0.12±0.05cm2) than the 3-D method (0.25±0.10cm2), p